start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=4 article-no= start-page=1769 end-page=1784 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=P53-armed Oncolytic Adenovirus Enhances the Efficacy of PD-1 Blockade in Neuroblastoma by Inducing Immunogenic Cell Death en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Aim: Neuroblastoma (NB) is a primary malignant tumor of the peripheral sympathetic nervous system. Although immunotherapy with immune checkpoint inhibitors (ICIs) targeting programmed cell death 1 (PD-1)/PD ligand 1 (PD-L1) has emerged as novel antitumor therapy, high-risk NB tumors are refractory to ICI therapy. Oncolytic virotherapy is expected to potentiate the antitumor immune response by inducing immunogenic cell death (ICD). In the present study, we assessed the therapeutic potential of OBP-301 and OBP-702, telomerase-specific oncolytic adenoviruses, for the induction of ICD and combined effect with PD-1 blockade against NB cells.
Materials and Methods: The cytopathic activity of OBP-301 and OBP-702 was assessed using three human MYCN-amplified NB cell lines (IMR-32, LA-N-5, and NB-1) and a murine non-MYCN-amplified NB cell line (Neuro-2a). Virus-mediated antitumor effect was assessed by analyzing cell viability, secretion of extracellular adenosine triphosphate (ATP) and high-mobility group box protein B1 (HMGB1), apoptosis, autophagy, and PD-L1 levels. A subcutaneous Neuro-2a tumor model was used to evaluate the in vivo antitumor effect of combination therapy with OBP-702 and anti-PD-1 antibody.
Results: OBP-702 exhibited stronger cytopathic activity, inducing ICD with secretion of ATP and HMGB1, compared to OBP-301 in human and murine NB cells. OBP-301 and OBP-702 increased apoptosis, autophagy, and PD-L1 expression in murine NB cells. Moreover, OBP-702 significantly prolonged the survival of tumor-bearing mice compared to monotherapy with PD-1 blockade.
Conclusion: OBP-702 is a promising antitumor strategy to promote the antitumor effect of ICIs by inducing ICD against NB tumors. en-copyright= kn-copyright= en-aut-name=TANIMORIMICHI en-aut-sei=TANI en-aut-mei=MORIMICHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TAZAWAHIROSHI en-aut-sei=TAZAWA en-aut-mei=HIROSHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TANIMOTOTERUTAKA en-aut-sei=TANIMOTO en-aut-mei=TERUTAKA kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NOUSOHIROSHI en-aut-sei=NOUSO en-aut-mei=HIROSHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WATANABEHINAKO en-aut-sei=WATANABE en-aut-mei=HINAKO kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OYAMATAKANORI en-aut-sei=OYAMA en-aut-mei=TAKANORI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=URATAYASUO en-aut-sei=URATA en-aut-mei=YASUO kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KAGAWASHUNSUKE en-aut-sei=KAGAWA en-aut-mei=SHUNSUKE kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NODATAKUO en-aut-sei=NODA en-aut-mei=TAKUO kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KURODASHINJI en-aut-sei=KURODA en-aut-mei=SHINJI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FUJIWARATOSHIYOSHI en-aut-sei=FUJIWARA en-aut-mei=TOSHIYOSHI kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Oncolys BioPharma, Inc. kn-affil= affil-num=8 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Pediatric Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=Neuroblastoma kn-keyword=Neuroblastoma en-keyword=oncolytic adenovirus kn-keyword=oncolytic adenovirus en-keyword=p53 kn-keyword=p53 en-keyword=immunogenic cell death kn-keyword=immunogenic cell death en-keyword=PD-1 kn-keyword=PD-1 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page=e202501237 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Informatics]Driven and Automated Optimization in Flow Electrochemical Synthesis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Electrochemical synthesis has emerged as a powerful platform for environmentally sustainable chemical transformations. When integrated with flow chemistry, electrosynthetic processes exhibit enhanced scalability, making them suitable for industrial applications. Recently, the integration of electrochemical flow systems with informatics techniques has accelerated the optimization of reaction conditions. Data-driven strategies facilitate rapid exploration of multidimensional parameter spaces, enabling identification of optimal reaction conditions with high efficiency. These advances have enabled the development of automated optimization systems. This review highlights recent progress in combining electrosynthesis, flow chemistry, and computational tools, focusing on representative examples that illustrate efficient optimization protocols and autonomous reaction development. By showcasing these developments, we discuss how the integration of these technologies is driving innovation in electrochemical synthesis. en-copyright= kn-copyright= en-aut-name=SatoEisuke en-aut-sei=Sato en-aut-mei=Eisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaniAkine en-aut-sei=Tani en-aut-mei=Akine kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakahamaTomohiro en-aut-sei=Nakahama en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MitsudoKoichi en-aut-sei=Mitsudo en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SugaSeiji en-aut-sei=Suga en-aut-mei=Seiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Department of Applied Chemistry, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=artificial intelligence kn-keyword=artificial intelligence en-keyword=electrochemical synthesis kn-keyword=electrochemical synthesis en-keyword=flow synthesis kn-keyword=flow synthesis en-keyword=laboratory automation kn-keyword=laboratory automation END start-ver=1.4 cd-journal=joma no-vol=380 cd-vols= no-issue= article-no= start-page=114924 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202604 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Constitutive activation of MC1R in the large-billed crow (Corvus macrorhynchos) and its potential role in black plumage en-subtitle= kn-subtitle= en-abstract= kn-abstract=Melanin-based plumage coloration in birds is largely regulated by the melanocortin 1 receptor (MC1R), a G protein?coupled receptor that promotes eumelanin synthesis via cAMP signaling. In domestic chickens, constitutively activating mutations such as the MC1R^E (E92K) allele cause melanistic phenotypes, demonstrating that persistent MC1R activation can drive generalized darkening. However, to our knowledge, no experimental study has directly demonstrated constitutive MC1R activation in wild birds exhibiting uniformly black plumage. We investigated the sequence and signaling properties of MC1R from the Large-billed Crow (Corvus macrorhynchos), a species with strongly eumelanin-dominant plumage. Crow MC1R exhibited elevated basal cAMP signaling and minimal responsiveness to ƒ¿-melanocyte-stimulating hormone (ƒ¿-MSH) in both stable Chinese hamster ovary (CHO-K1) cells and transient CRE-luciferase assays in HEK293T cells, demonstrating ligand-independent activation comparable to that observed in the melanizing chicken MC1R^E (E92K) allele. Comparative sequence analysis identified multiple substitutions conserved across Corvus species. Among these, E12K and E18K were functionally evaluated based on prior associations with melanism in other birds. Although E12K modestly increased basal signaling in chicken MC1R, E18K alone or in combination with E12K did not reproduce crow-level constitutive activity, and reciprocal substitutions in crow MC1R failed to abolish ligand-independent activation. These findings demonstrate that crow MC1R possesses constitutive activity and suggest that this phenotype reflects lineage-specific modifications rather than a single activating substitution. Our results provide experimental evidence that constitutive MC1R activation is a plausible molecular mechanism that may contribute to the black plumage in the Large-billed Crow, although a direct causal relationship remains to be established. en-copyright= kn-copyright= en-aut-name=NakanoSaya en-aut-sei=Nakano en-aut-mei=Saya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TashiroYuichi en-aut-sei=Tashiro en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FukuchiHibiki en-aut-sei=Fukuchi en-aut-mei=Hibiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AizawaSayaka en-aut-sei=Aizawa en-aut-mei=Sayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakeuchiSakae en-aut-sei=Takeuchi en-aut-mei=Sakae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=MC1R kn-keyword=MC1R en-keyword=Constitutive activation kn-keyword=Constitutive activation en-keyword=Ligand-independent signaling kn-keyword=Ligand-independent signaling en-keyword=Melanism kn-keyword=Melanism en-keyword=Plumage coloration kn-keyword=Plumage coloration en-keyword=Corvus macrorhynchos kn-keyword=Corvus macrorhynchos END start-ver=1.4 cd-journal=joma no-vol=283 cd-vols= no-issue=2 article-no= start-page=78 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Simons Observatory: Detector Polarization Angle Calibration Using a Sparse Wire Grid with Initial Datasets of the Small-aperture Telescopes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Improved measurements of B-modes in the cosmic microwave background can be obtained through accurate calibration of the orientation of detector antennas as projected onto the sky. Miscalibration of the detector polarization angle leads to a leakage of E-modes into B-modes, which can bias the detection of the latter. To achieve a ƒÐ(r) of 0.003, the Simons Observatory small-aperture telescopes are required to calibrate the global polarization angle on the sky with an accuracy ?0.‹1. We demonstrate a fully remote-controllable calibration system using a gsparse wire grid,h which injects a rotatable linear polarized signal across the telescopefs focal plane. This calibration system is installed and operational on one of the small-aperture telescopes at its observing site at the Parque Astron?mico in the Atacama desert in Chile. We developed a pipeline for the detector polarization angle calibration, and demonstrate it using initial data for 93 and 145 GHz frequency bands. The observed distribution of detector polarization angles is in agreement with the instrument design. Statistical uncertainties for the relatively calibrated polarization angles are 0.‹02 and 0.‹03 at 93 and 145 GHz, respectively. Systematic uncertainty was evaluated to be 0.‹08 at the hardware development and fabrication stage. Their sum in quadrature is less than 0.‹1. en-copyright= kn-copyright= en-aut-name=NakataHironobu en-aut-sei=Nakata en-aut-mei=Hironobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AdachiShunsuke en-aut-sei=Adachi en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamadaKyohei en-aut-sei=Yamada en-aut-mei=Kyohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=RandallMichael en-aut-sei=Randall en-aut-mei=Michael kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KasaiYutaro en-aut-sei=Kasai en-aut-mei=Yutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ArnoldKam en-aut-sei=Arnold en-aut-mei=Kam kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=BixlerBryce en-aut-sei=Bixler en-aut-mei=Bryce kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ChinoneYuji en-aut-sei=Chinone en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=CrowleyKevin T. en-aut-sei=Crowley en-aut-mei=Kevin T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=DachlythraNadia en-aut-sei=Dachlythra en-aut-mei=Nadia kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=Day-WeissSamuel en-aut-sei=Day-Weiss en-aut-mei=Samuel kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=GalitzkiNicholas en-aut-sei=Galitzki en-aut-mei=Nicholas kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=GiardielloSerena en-aut-sei=Giardiello en-aut-mei=Serena kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=JohnsonBradley R. en-aut-sei=Johnson en-aut-mei=Bradley R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=KeatingBrian en-aut-sei=Keating en-aut-mei=Brian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=KoopmanBrian J. en-aut-sei=Koopman en-aut-mei=Brian J. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=KusakaAkito en-aut-sei=Kusaka en-aut-mei=Akito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=LashnerJack en-aut-sei=Lashner en-aut-mei=Jack kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=NatiFederico en-aut-sei=Nati en-aut-mei=Federico kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=PageLyman en-aut-sei=Page en-aut-mei=Lyman kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=SasakiDaichi en-aut-sei=Sasaki en-aut-mei=Daichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=SuenoYoshinori en-aut-sei=Sueno en-aut-mei=Yoshinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=SuzukiJunya en-aut-sei=Suzuki en-aut-mei=Junya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=TajimaOsamu en-aut-sei=Tajima en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=TsanTran en-aut-sei=Tsan en-aut-mei=Tran kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= affil-num=1 en-affil=Department of Physics, Faculty of Science, Kyoto University kn-affil= affil-num=2 en-affil=Okayama University, Department of Physics kn-affil= affil-num=3 en-affil=Joseph Henry Laboratories of Physics, Jadwin Hall, Princeton University kn-affil= affil-num=4 en-affil=Joseph Henry Laboratories of Physics, Jadwin Hall, Princeton University kn-affil= affil-num=5 en-affil=Department of Physics, Faculty of Science, Kyoto University kn-affil= affil-num=6 en-affil=Joseph Henry Laboratories of Physics, Jadwin Hall, Princeton University kn-affil= affil-num=7 en-affil=Department of Physics, University of California San Diego kn-affil= affil-num=8 en-affil=QUP (WPI), KEK kn-affil= affil-num=9 en-affil=Joseph Henry Laboratories of Physics, Jadwin Hall, Princeton University kn-affil= affil-num=10 en-affil=Department of Physics, University of Milano-Bicocca kn-affil= affil-num=11 en-affil=Joseph Henry Laboratories of Physics, Jadwin Hall, Princeton University kn-affil= affil-num=12 en-affil=Department of Physics, University of Texas at Austin kn-affil= affil-num=13 en-affil=School of Physics and Astronomy, Cardiff University kn-affil= affil-num=14 en-affil=University of Virginia, Department of Astronomy kn-affil= affil-num=15 en-affil=Department of Physics, University of California San Diego kn-affil= affil-num=16 en-affil=Wright Laboratory, Department of Physics, Yale University kn-affil= affil-num=17 en-affil=Kavli IPMU (WPI), UTIAS, The University of Tokyo kn-affil= affil-num=18 en-affil=Wright Laboratory, Department of Physics, Yale University kn-affil= affil-num=19 en-affil=Department of Physics, University of Milano-Bicocca kn-affil= affil-num=20 en-affil=Joseph Henry Laboratories of Physics, Jadwin Hall, Princeton University kn-affil= affil-num=21 en-affil=Department of Physics, The University of Tokyo kn-affil= affil-num=22 en-affil=Joseph Henry Laboratories of Physics, Jadwin Hall, Princeton University kn-affil= affil-num=23 en-affil=Department of Physics, Faculty of Science, Kyoto University kn-affil= affil-num=24 en-affil=Department of Physics, Faculty of Science, Kyoto University kn-affil= affil-num=25 en-affil=Physics Division, Lawrence Berkeley National Laboratory kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=200403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The seed collection pictorial record of ruins exrcavartion kn-title=ˆâÕoŽm‚ÌŽíŽqW¬}˜^ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ŽR–{‰x¢ kn-aut-sei=ŽR–{ kn-aut-mei=‰x¢ aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Šâú±Žu•Û kn-aut-sei=Šâú± kn-aut-mei=Žu•Û aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰«—zŽq kn-aut-sei=‰« kn-aut-mei=—zŽq aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw–„‘ •¶‰»à’²¸Œ¤‹†ƒZƒ“ƒ^[ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw–„‘ •¶‰»à’²¸Œ¤‹†ƒZƒ“ƒ^[ affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwŠÂ‹«—HŠw•” END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=2 article-no= start-page=bio062463 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Gap junction-mediated signaling coordinates Rhodopsin coupling for Drosophila color vision en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Drosophila compound eye is composed of approximately 800 ommatidia, and every ommatidium contains eight photoreceptor cells, six outer cells (R1-R6) and two inner cells (R7 and R8), and accessory cells (cone and pigment cells). The expression of rhodopsin genes in R7 and R8 is highly coordinated through an instructive signal from R7 to R8. The activity of the homeodomain protein Defective proventriculus in R1 is also required to transmit this instructive signal, suggesting that cell?cell communication between R7, R1, and R8 is important to generate the pattern of Rh expression in R7/R8 (Rhodopsin coupling). As cell junctions play crucial roles in maintaining the structural and functional integrity of tissues, we tested whether cell junction proteins are involved in the interactions between photoreceptor cells. Here, we demonstrate that gap junction proteins innexin 2 and innexin 7 in accessory cells are necessary for transmitting signals from R7 to R8. In addition, Notch-mediated accessory cell development and Rhodopsin coupling in R7/R8 are highly correlated. Our results provide evidence that functional coupling of two different neurons, R7 and R8, is established through gap junction-mediated signaling from adjacent accessory cells. en-copyright= kn-copyright= en-aut-name=ZhangXuanshuo en-aut-sei=Zhang en-aut-mei=Xuanshuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShinjoRyoki en-aut-sei=Shinjo en-aut-mei=Ryoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KitamataManabu en-aut-sei=Kitamata en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OtsuneShinichi en-aut-sei=Otsune en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakagoshiHideki en-aut-sei=Nakagoshi en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Division of Biological Sciences, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Biological Sciences, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Health Science, Advanced Comprehensive Research Organization, Teikyo University kn-affil= affil-num=4 en-affil=Division of Biological Sciences, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Division of Biological Sciences, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Drosophila kn-keyword=Drosophila en-keyword=Eye kn-keyword=Eye en-keyword=Gap junction kn-keyword=Gap junction en-keyword=Innexin kn-keyword=Innexin en-keyword=Opsin kn-keyword=Opsin END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Triangulation in teaching probability: teaching materials for the theoretical foundations of probability in real-world applications en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper proposes using the concept of triangulation with probabilistic models as a means to enhance theoretical inversion for deepening studentsf understanding of the nature of probability in real-world contexts. Triangulation refers to the combined application of multiple methodologies to investigate the same phenomenon, particularly in the social sciences. Theoretical inversion refers to a shift in focus from surprising outcomes to the theoretical foundations of probability. The paper introduces three types of problem-solving tasks designed to enhance one of four types of triangulations: theory triangulation. Theoretical inversion is expected to emerge through engaging in these tasks. The characteristics of the problems are as follows. Problem 1 promotes students to compare different probabilistic models of events under similar procedures. Problem 2 provides students with an opportunity to simplify an experiment by omitting steps that add no new information. Problem 3 enhances studentsf ability to recognise how subtle differences in the experimental setup can affect the resulting probability. These tasks are designed to encourage students to view probabilistic reasoning as a form of modelling and to appreciate the importance of assumptions, definitions of elementary events, and clarity in procedural descriptions. en-copyright= kn-copyright= en-aut-name=UegataniYusuke en-aut-sei=Uegatani en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshibashiIppo en-aut-sei=Ishibashi en-aut-mei=Ippo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakotaAya en-aut-sei=Sakota en-aut-mei=Aya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Hiroshima University High School kn-affil= affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil= affil-num=3 en-affil=Hiroshima University High School kn-affil= en-keyword=Probability kn-keyword=Probability en-keyword=triangulation kn-keyword=triangulation en-keyword=mathematical modelling kn-keyword=mathematical modelling en-keyword=theoretical inversion kn-keyword=theoretical inversion END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=5 article-no= start-page=2308 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Aerobic Exercise Attenuates Epidermal Hyperplasia in an Obesity-Associated Psoriasiform Dermatitis Model en-subtitle= kn-subtitle= en-abstract= kn-abstract=Obesity is an important risk factor for psoriasis, and clinical studies indicate that exercise interventions can improve disease severity. However, the mechanisms by which exercise influences psoriatic pathogenesis remain insufficiently understood. To investigate the effects of aerobic exercise on obesity-associated psoriasis, wild-type mice were fed a high-fat diet (HFD) for 7 weeks to induce obesity and subsequently underwent moderate-intensity treadmill running for 3 weeks. Psoriasiform dermatitis was induced by daily topical application of imiquimod (IMQ) to the skin for five consecutive days. HFD increased body weight, epididymal fat mass, and serum cholesterol. HFD-fed mice developed more severe IMQ-induced psoriatic skin changes compared with normal diet-fed mice. Treadmill exercise modestly reduced body weight gain and attenuated epidermal hyperplasia in HFD-fed mice. In contrast, inflammatory cytokine expression, including Tnfa, Il17a, and Il23a, showed modest increases in the skin of HFD-fed exercised mice, which did not parallel the improvement in epidermal hyperplasia. Overall, these findings indicate that while obesity exacerbates psoriasiform dermatitis, aerobic exercise ameliorates epidermal hyperplasia in obese mice without corresponding changes in inflammatory cytokine expression in the skin, suggesting that exercise may influence psoriatic skin changes through multiple metabolic and immunological pathways. en-copyright= kn-copyright= en-aut-name=MatsudaYoshihiro en-aut-sei=Matsuda en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MorizaneShin en-aut-sei=Morizane en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakezakiDaiki en-aut-sei=Takezaki en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakamotoYuma en-aut-sei=Sakamoto en-aut-mei=Yuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=BabaNobuyasu en-aut-sei=Baba en-aut-mei=Nobuyasu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IsekiMasanori en-aut-sei=Iseki en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KawakamiYoshio en-aut-sei=Kawakami en-aut-mei=Yoshio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShiomiTatsushi en-aut-sei=Shiomi en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MukaiTomoyuki en-aut-sei=Mukai en-aut-mei=Tomoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Immunology and Molecular Genetics, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Immunology and Molecular Genetics, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Immunology and Molecular Genetics, Kawasaki Medical School kn-affil= affil-num=7 en-affil=Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Pathology, Kawasaki Medical School kn-affil= affil-num=9 en-affil=Department of Immunology and Molecular Genetics, Kawasaki Medical School kn-affil= en-keyword=psoriasis kn-keyword=psoriasis en-keyword=obesity kn-keyword=obesity en-keyword=aerobic exercise kn-keyword=aerobic exercise en-keyword=imiquimod kn-keyword=imiquimod en-keyword=high-fat diet kn-keyword=high-fat diet END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=2 article-no= start-page=364 end-page=370 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260221 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Functional Transport Properties of Human Zinc Transporter 1: Kinetics and pH-Dependency en-subtitle= kn-subtitle= en-abstract= kn-abstract=Intracellular zinc (Zn2+) homeostasis is essential for physiological and pathological processes and is strictly regulated by Zn2+ transporters. Zinc transporter 1 (ZnT1) is a ubiquitously expressed plasma membrane-localized Zn transporter that exports Zn2+ from the cytoplasm to the extracellular space. However, the functional transport properties regarding kinetics and driving forces of ZnT1 remain debatable. In this study, we established a cell-free proteoliposome assay system and demonstrated that ZnT1 transports Zn2+ with high affinity in pH-dependent and pH-independent manners. The Km and Vmax of pH-dependent Zn2+ transport were 0.40 ƒÊM and 15.13 nmol/min/mg protein, and those of pH-independent Zn2+ transport were 0.52 ƒÊM and 8.88 nmol/min/mg protein (low concentrations of Zn2+), 3.02 ƒÊM and 17.59 nmol/min/mg protein (high concentrations of Zn2+), respectively, suggesting biphasic kinetic components of Zn2+ transport. Even without pH gradient formation, ZnT1 exhibits potent Zn2+ transport activity. In pH dependency, Zn2+ transport activity was higher at an inside pH of 6.0 than at 6.5?7.5 for proteoliposomes, despite the same ƒ¢pH of 0.5?1.5. The Zn2+ transport activity decreased at an outside pH of 8.0, despite an increase in ƒ¢pH. Although previous studies have proposed that ZnT1-mediated Zn2+ transport activity is driven by a calcium (Ca2+) gradient and not by a pH gradient, Ca2+ does not enhance Zn2+ transport activity in the presence or absence of a pH gradient. These results strongly suggest that ZnT1 protein transports Zn2+ optimally at a specific pH and exports excess intracellular Zn2+ even without ƒ¢pH. en-copyright= kn-copyright= en-aut-name=YoshiokaYuma en-aut-sei=Yoshioka en-aut-mei=Yuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyajiTakaaki en-aut-sei=Miyaji en-aut-mei=Takaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Department of Molecular Membrane Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Molecular Membrane Biology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=zinc transporter 1 kn-keyword=zinc transporter 1 en-keyword=SLC30A1 kn-keyword=SLC30A1 en-keyword=zinc kn-keyword=zinc en-keyword=pH kn-keyword=pH en-keyword=proteoliposome kn-keyword=proteoliposome END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=10464 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Liquid?liquid phase separation by caged coacervating peptides en-subtitle= kn-subtitle= en-abstract= kn-abstract=Liquid?liquid phase separation is an important biomolecular process in the formation of membraneless intracellular organelles that has inspired the development of artificial droplet systems. We developed caged coacervating peptides (CCPs) based on a histidine-rich squid beak protein sequence. The peptides were caged with a photodeprotectable (7-diethylaminocoumarin-4-yl)methoxycarbonyl group. The CCPs formed coacervates in the caged state and were partially dispersed upon blue-light irradiation. Photo-uncaging occurred rapidly, inducing coacervate dispersion. A mutant CCP with reduced ƒÎ?ƒÎ interactions exhibited efficient photo-dependent disassembly and enabled the encapsulation and release of a fluorescently labeled adenosine 5Œ-triphosphate (Bodipy-ATP) upon irradiation. These CCPs offer an efficient light-controlled approach for biomolecular encapsulation within coacervates and targeted drug delivery. en-copyright= kn-copyright= en-aut-name=BandoAkinari en-aut-sei=Bando en-aut-mei=Akinari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitamatsuMizuki en-aut-sei=Kitamatsu en-aut-mei=Mizuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KanazakiYuuki en-aut-sei=Kanazaki en-aut-mei=Yuuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TojoRika en-aut-sei=Tojo en-aut-mei=Rika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WatanabeKazunori en-aut-sei=Watanabe en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OhtsukiTakashi en-aut-sei=Ohtsuki en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Department of Applied Chemistry, Kindai University kn-affil= affil-num=3 en-affil=Department of Applied Chemistry, Kindai University kn-affil= affil-num=4 en-affil=Department of Applied Chemistry, Kindai University kn-affil= affil-num=5 en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=6 en-affil=Department of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= en-keyword=Caged coacervating peptide kn-keyword=Caged coacervating peptide en-keyword=Liquid?liquid phase separation kn-keyword=Liquid?liquid phase separation en-keyword=Light kn-keyword=Light END start-ver=1.4 cd-journal=joma no-vol=26 cd-vols= no-issue=1 article-no= start-page=558 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of contact-active antibacterial properties of cetylpyridinium chloride?graphene oxide coatings on dental restorative and titanium surfaces: an in vitro study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective Biofilm formation on dental restorative materials and implant surfaces plays a central role in the development of dental caries, periodontal disease, and peri-implantitis. Durable antimicrobial surface treatments that inhibit bacterial adhesion and biofilm formation remain a significant unmet need in restorative and implant dentistry. Therefore, this study aimed to develop a composite coating combining cetylpyridinium chloride and graphene oxide, and to evaluate its durable antibacterial surface modification under in vitro conditions.
Methods A composite coating consisting of cetylpyridinium chloride and graphene oxide was prepared and applied to composite resin and titanium surfaces. Antibacterial activity against Streptococcus mutans and Porphyromonas gingivalis was evaluated using adenosine triphosphate assays and fluorescence-based live/dead staining. Coating retention after washing and air-drying was assessed by optical microscopy and Raman spectroscopy.
Results Cetylpyridinium chloride-graphene oxide-coated surfaces showed a significant reduction in bacterial viability compared with phosphate-buffered saline, ethanol, and cetylpyridinium chloride-only controls. Antibacterial effects were maintained after rinsing and air-drying on both composite resin and titanium surfaces. Raman spectroscopy confirmed the persistence of characteristic graphene oxide bands after washing, indicating stable retention of the coating on the material surfaces.
Conclusions Cetylpyridinium chloride?graphene oxide coatings demonstrate sustained surface-associated antibacterial activity against key cariogenic and periodontal pathogens and remain stably adhered to common dental restorative and implant materials after washing. These findings suggest that cetylpyridinium chloride?graphene oxide coatings may serve as a durable contact-active surface modification strategy to reduce biofilm formation associated with dental caries and peri-implantitis. en-copyright= kn-copyright= en-aut-name=OkuboKeisuke en-aut-sei=Okubo en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KanoGen en-aut-sei=Kano en-aut-mei=Gen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KomodaMasato en-aut-sei=Komoda en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KamataHideyuki en-aut-sei=Kamata en-aut-mei=Hideyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakamuraShin en-aut-sei=Nakamura en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=Shinoda-ItoYuki en-aut-sei=Shinoda-Ito en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OmoriKazuhiro en-aut-sei=Omori en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NishinaYuta en-aut-sei=Nishina en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TakashibaShogo en-aut-sei=Takashiba en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Periodontics and Endodontics, Field of Medical Development, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Pathophysiology - 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kn-title=‘ÌŒn‰»‚ð–ÚŽw‚µ‚ÄŠ„‡‚Ìl‚¦‚ð[‚ß‚é”ä‚ÌŽö‹Æ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Z–{Œ¤‹†‚Ì–Ú“I‚ÍC ¬ŠwZŽZ”‰È‚É‚¨‚¯‚é”ä‚ÌŽö‹ÆŽÀ‘H‚ð’Ê‚µ‚ÄCŽ™“¶Ž©‚炪Š„‡‚Ìl‚¦‚ð”­“W“IE“‡“I‚ÉlŽ@‚µ‚Ä[‚߂邱‚Æ‚É‚ ‚éD‘æ‚UŠw”Nu”ä‚Æ‚»‚Ì—˜—pv‚ÌŠwK‚Ü‚Å‚ÉŠw‚ñ‚¾ŠùK‚ÌŠ„‡‚Ìl‚¦‚ÆV‹K‚Ì”ä‚Ìl‚¦‚𓇓IE”­“W“I‚ÉlŽ@‚·‚邱‚Æ‚ÅŠ„‡‚Ìl‚¦‚Í[‚Ü‚èC‘ÌŒn‰»‚·‚éD‚µ‚©‚µCŠ„‡‚Æ”ä‚ð•ÊX‚ÌŠT”O‚Æ‚µ‚Ä‘¨‚¦‚Ä‚µ‚Ü‚¢C‘ÌŒn‰»‚ª}‚ç‚ê‚Ä‚¢‚È‚¢ó‹µ‚É‚ ‚éD”ä‚Í‚`F‚aCŠ„‡‚Í‚`^‚a‚Æ•\Œ»•û–@‚͈Ⴄ‚à‚Ì‚ÌC—¼ŽÒ‚Í‚Q‚‚̔—Ê‚ÌŠÖŒW‚ð•\‚·ê‡Cuˆê•û‚ðŠî€‚É‚µ‚ÄC‚à‚¤ˆê•û‚Í‚Ç‚ñ‚È‘å‚«‚³‚É‚È‚é‚©‚𑨂¦‚év‚±‚Æ‚Í–{Ž¿‚É“¯‚¶‚Å‚ ‚éD–{ŽÀ‘H‚ð’Ê‚µ‚ÄCŽ™“¶Ž©‚炪‘n‘¢“I”Šw—Í‚ð”­Šö‚µCŒÂ‚ÌŽ©—§“I‚Èl‚¦‚ðW’c‚Å‚Ì‹¦“­“I‚ÈU‚è•Ô‚芈“®‚ð’Ê‚µ‚ÄŠ„‡‚Æ”ä‚ðŠÖ˜A•t‚¯C“‡“IE”­“W“I‚ÉlŽ@‚·‚邱‚Æ‚ÅCŠ„‡‚Æ”ä‚ÌŠT”O‚Í—Z‡‚³‚êC‘ÌŒn‰»‚ª}‚ç‚ê‚é‚Æ‚¢‚¤Ž¦´‚𓾂½D en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ŽRú±—N‘¾ kn-aut-sei=ŽRú± kn-aut-mei=—N‘¾ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRŽs—§•Ÿ“c¬ŠwZ en-keyword=Š„‡‚̈Ӗ¡ kn-keyword=Š„‡‚̈Ӗ¡ en-keyword=”ä‚̈Ӗ¡E«Ž¿ kn-keyword=”ä‚̈Ӗ¡E«Ž¿ en-keyword=“‡E”­“W kn-keyword=“‡E”­“W en-keyword=‘ÌŒn‰» kn-keyword=‘ÌŒn‰» END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page=1 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=¬ŠwZ3”N¶‚Ì‚í‚èŽZ‚Ì’PŒ³‚É‚¨‚¯‚é“ñd‚É“‡‚·‚éê–Ê‚ÌŽw“±‚ɂ‚¢‚Ä `‚©‚¯ŽZC“™•ªœC•ïŠÜœ‚Ì“‡“I”cˆ¬‚É‚¨‚¯‚é‚©‚¯ŽZ‚̈Ӗ¡—‰ð‚Ìd—v«` en-subtitle= kn-subtitle= en-abstract= kn-abstract=@•½¬29”N“xŽ¦‚ÌŠwKŽw“±—v—Ì‚Å‚ÍC¬ŠwZŽZ”‰È‚Ì–Ú•W‚ð(1)’mŽ¯‹y‚Ñ‹Z”\C(2)Žvl—ÍC”»’f—ÍC•\Œ»—Í“™C(3)Šw‚Ñ‚ÉŒü‚©‚¤—ÍClŠÔ«“™‚ÌŽO–{‚Ì’Œ‚ÉŠî‚¢‚ÄŽ¦‚µ‚Ä‚¢‚éD“Á‚É(2)Žvl—ÍC”»’f—ÍC•\Œ»—Í“™‚Ì“à—e‚Æ‚µ‚ÄCuŠî–{“I‚È”—Ê‚â}Œ`‚Ì«Ž¿‚È‚Ç‚ðŒ©o‚µ“‡“IE”­“W“I‚ÉlŽ@‚·‚é—Ív‚ð—{‚¤‚Æ‹Lq‚³‚êC“‡‚ð’Ê‚µ‚ÄŽq‚Ç‚à‚Ìl‚¦‚é—Í‚ÌŒüオ–ÚŽw‚³‚ê‚Ä‚¢‚éD
@–{e‚ÍC‘æ 3 Šw”N‚Ì‚í‚èŽZ‚Ì“™•ªœ‚Æ•ïŠÜœ‚Ì–â‘è‚ð—lX‚ÈŽ‹“_‚©‚ç”äŠr‚µCŽ™“¶‚É“‡‚·‚é‘ÌŒ±‚ð‚³‚¹‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½‚à‚Ì‚Å‚ ‚éDŽö‹Æ•ªÍ‚ÌŒ‹‰ÊC“‡‚ÉŠÖ‚µ‚Ä‚ÍC“™•ªœ‚Æ•ïŠÜœ‚𓇂·‚邾‚¯‚Å‚È‚­C‚³‚ç‚É‚©‚¯ŽZ‚Æ‚í‚èŽZ‚ð‘å‚«‚­‚©‚¯ŽZ‚Æ‚Ý‚Ä“‡‚·‚邱‚ÆC‚‚܂è“ñd‚É“‡‚·‚é•K—v‚ª‚ ‚éꇂª‚ ‚èC‚©‚¯ŽZ‚̈Ӗ¡—‰ð‚ª‚±‚Ìê–Ê‚Ì—‰ð‚𕂯‚é‚Æ‚Æ‚à‚ÉC“ñd‚Ì“‡‚É‹Nˆö‚·‚éŠw‚Ñ‚Ì¢“ï‚ðŽw“E‚·‚邱‚Æ‚ª‚Å‚«‚éD en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‘å¼—é kn-aut-sei=‘å¼ kn-aut-mei=—é aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ªè³˜a kn-aut-sei=‰ªè kn-aut-mei=³˜a aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRŽs—§•Ÿ•l¬ŠwZ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw en-keyword=ŽZ” kn-keyword=ŽZ” en-keyword=‚í‚èŽZ kn-keyword=‚í‚èŽZ en-keyword=“‡ kn-keyword=“‡ en-keyword=“™•ªœ kn-keyword=“™•ªœ en-keyword=•ïŠÜœ kn-keyword=•ïŠÜœ en-keyword=‚©‚¯ŽZ kn-keyword=‚©‚¯ŽZ END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Šª“ªŒ¾ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=’†ìªŽ÷ kn-aut-sei=’†ì kn-aut-mei=ªŽ÷ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=31 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=7 article-no= start-page=3143 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=CXCR2-Dependent Infiltration of Tumor-Associated Neutrophils Is Linked to Enhanced CD8+ T Cell Effector Function and Reduced Lung Metastasis in 4T1 Breast Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=Triple-negative breast cancer (TNBC) is characterized by prominent neutrophil infiltration; however, its significance remains controversial. Here, we investigated the role of neutrophil chemoattractant receptors in TNBC progression and metastasis. In contrast to wild-type (WT), Fpr1?/?, and Fpr2?/? mice, neutrophils were almost completely absent in 4T1 tumors from Cxcr2?/? mice, indicating a dominant role for CXCR2 in the recruitment of tumor-associated neutrophils, leading us to use Cxcr2?/? mice for further studies. Primary tumor growth was comparable between WT and Cxcr2?/? mice, whereas lung metastasis was significantly increased in Cxcr2?/? mice, with reduced expression of inflammatory cytokines, chemokines and cytotoxic molecules, including granzyme B and perforin, in primary tumors and metastatic lungs of Cxcr2?/? mice. In vitro, WT, but not Cxcr2?/?, neutrophils enhanced CD8+ T cell activation, partly via ICAM-1, and directly induced tumor cell death, supporting their anti-tumor function. To assess clinical relevance, transcriptomic data were analyzed. High neutrophil infiltration combined with elevated CXCR2 expression, and to a lesser extent CXCR1 expression, was associated with improved prognosis in patients with basal-like BC that largely overlaps with TNBC. Collectively, these findings suggest that CXCR2-mediated neutrophil recruitment exerts protective, anti-tumor effects and may represent a new prognostic marker for TNBC patients. en-copyright= kn-copyright= en-aut-name=LiTiantian en-aut-sei=Li en-aut-mei=Tiantian kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshimuraTeizo en-aut-sei=Yoshimura en-aut-mei=Teizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TianMiao en-aut-sei=Tian en-aut-mei=Miao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NishidaGakushi en-aut-sei=Nishida en-aut-mei=Gakushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=LiChunning en-aut-sei=Li en-aut-mei=Chunning kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FujisawaMasayoshi en-aut-sei=Fujisawa en-aut-mei=Masayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MatsukawaAkihiro en-aut-sei=Matsukawa en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=breast cancer kn-keyword=breast cancer en-keyword=neutrophils kn-keyword=neutrophils en-keyword=CD8+ T cells kn-keyword=CD8+ T cells en-keyword=chemokines kn-keyword=chemokines en-keyword=chemokine receptors kn-keyword=chemokine receptors en-keyword=tumor microenvironment kn-keyword=tumor microenvironment END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue=4 article-no= start-page=760 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The Role of Nitrate-Reducing Bacteria Isolated from Helicobacter pylori-Infected Individuals in Gastric Cancer Development en-subtitle= kn-subtitle= en-abstract= kn-abstract=Helicobacter pylori is a Gram-negative bacterium that inhabits the gastric mucosa, with a global prevalence in humans of approximately 40%. It is likely the cause of 90% of gastric cancer (GC) cases and thus considered the most prominent driver of GC development. However, during gastric mucosal atrophy, other bacteria such as nitrate-reducing bacteria (NRB) also proliferate. In this study, we isolated NRB from patients with gastritis and GC to examine their effects on the epithelial cell cycle and production of various cytokines in monocytic cell lines. Bacterial counts (excluding H. pylori and NRB) increased with the progression of gastric mucosal atrophy and were significantly higher in patients with GC. Gastric epithelial cell lines were stimulated with isolated NRB, and the proportion of cells in each cell cycle was measured. Strains from patients with open-type gastritis progressed more rapidly through cell cycles than those from patients with GC. NRB isolated from gastric cancer had high nitrate-reducing activity. Thus, NRB may contribute to GC progression during H. pylori-induced carcinogenesis. Therefore, evaluating gastric atrophy and microbiota may be important for managing the risk of GC. en-copyright= kn-copyright= en-aut-name=KuwagiSerika en-aut-sei=Kuwagi en-aut-mei=Serika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=GotohKazuyoshi en-aut-sei=Gotoh en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KomatsubaraMarina en-aut-sei=Komatsubara en-aut-mei=Marina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TsujiShuma en-aut-sei=Tsuji en-aut-mei=Shuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkanoueShyoutarou en-aut-sei=Okanoue en-aut-mei=Shyoutarou kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=UchiyamaJumpei en-aut-sei=Uchiyama en-aut-mei=Jumpei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=WatanabeAkari en-aut-sei=Watanabe en-aut-mei=Akari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YokotaKenji en-aut-sei=Yokota en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Bacteriology, Academic Field of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Bacteriology, Academic Field of Health Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Bacteriology, Academic Field of Health Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Bacteriology, Academic Field of Health Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Academic Field of Medicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Himeji Red Cross Hospital kn-affil= affil-num=7 en-affil=Department of Bacteriology, Academic Field of Medicine Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Oral Health Care and Rehabilitation, Institute of Biomedical Sciences, Graduate School, Tokushima University kn-affil= affil-num=9 en-affil=Department of Bacteriology, Academic Field of Health Sciences, Okayama University kn-affil= en-keyword=Helicobacter pylori infection kn-keyword=Helicobacter pylori infection en-keyword=gastric cancer kn-keyword=gastric cancer en-keyword=nitrate-reducing bacteria kn-keyword=nitrate-reducing bacteria en-keyword=gastritis kn-keyword=gastritis END start-ver=1.4 cd-journal=joma no-vol=171 cd-vols= no-issue=2 article-no= start-page=xaag004 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202602 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Rho kinase and RND3 regulate the direct effect of estradiol-17ƒÀ on oviductal tonus en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ensuring the timely transport of gametes and embryos within the oviduct is essential for the successful establishment of pregnancy. This study investigated the direct effect of estradiol-17ƒÀ (E2) on bovine oviductal contractility and the differences in responsiveness to E2 during the estrous cycle. Bovine isthmic tissues from four estrous stages were analyzed using the Magnus method to assess contractile responses to E2 and related reagents. Protein expression of G-protein-coupled estrogen receptor 1 (GPER1) and components of the RhoA/Rho kinase (ROCK) signaling pathway were also evaluated. E2 and a GPER1 agonist significantly increased oviductal tonus at 1?4?days after ovulation. This effect was significantly suppressed by treatment with a GPER1 antagonist and a ROCK inhibitor. At 1?4?days after ovulation, both ROCK II expression and ROCK activity were elevated. E2 also enhanced phosphorylation of myosin phosphatase targeting subunit 1 (MYPT1) and myosin light chain (MLC), key downstream targets of ROCK. Before ovulation, when endogenous E2 levels peak, the expression of RND3?a ROCK inhibitor?was upregulated. The application of an RND inhibitor restored E2 responsiveness in oviductal tonus, ROCK activity, and the phosphorylation of MYPT1 and MLC in oviductal tissues before ovulation. These findings suggest that E2 directly increases oviductal tonus via GPER1 and ROCK/MYPT1/MLC activation at 1?4?days after ovulation. Differences in oviductal responsiveness to E2 during the estrous cycle appear to be mediated by the expression of ROCK and RND3. This mechanism can enable sperm transport within the oviduct at an appropriate time. en-copyright= kn-copyright= en-aut-name=KubotaSayaka en-aut-sei=Kubota en-aut-mei=Sayaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkawaraRisa en-aut-sei=Okawara en-aut-mei=Risa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawanoKohei en-aut-sei=Kawano en-aut-mei=Kohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KimuraKoji en-aut-sei=Kimura en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Laboratory of Reproductive Physiology, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=School of Agriculture, Okayama University kn-affil= affil-num=3 en-affil=Laboratory of Reproductive Physiology, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Laboratory of Reproductive Physiology, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=estradiol-17ƒÀ kn-keyword=estradiol-17ƒÀ en-keyword=oviduct kn-keyword=oviduct en-keyword=rho kinase kn-keyword=rho kinase en-keyword=RND3 kn-keyword=RND3 END start-ver=1.4 cd-journal=joma no-vol=14 cd-vols= no-issue= article-no= start-page=30309 end-page=30326 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=2026 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Self-Adaptive Framework for Deploying Machine Learning Systems Without Ground-Truth Data at Runtime en-subtitle= kn-subtitle= en-abstract= kn-abstract=In recent years, the practical application of machine learning technology has rapidly progressed, accelerating its adoption across various fields. In this context, studies into the effective operation of machine learning systems in real-world environments have become essential. In actual operational settings, the distribution of input data often changes over time, leading to a significant decline in the predictive performance of models. Additionally, the lack of ground-truth data for test data during operation can sometimes make adaptation through retraining difficult. This study proposes a framework that autonomously adapts to changes in input data distribution, even in environments where ground-truth data for test data is unavailable during operation. This framework analyzes the distribution of input data and selects the appropriate predictive model based on the state of the distribution. To ensure optimal model selection, the framework employs two complementary approaches: 1) dynamically switching between multiple pre-trained models with different feature sets according to environmental changes and 2) building ensemble models based on the distribution of the test data. These approaches enable the framework to autonomously adapt to shifts in data distribution, even in operational settings where ground-truth data is unavailable. Evaluation experiments using both simulated and real-world data assessed the predictive performance of the proposed method through metrics such as R2, RMSE, and MAE. Compared to conventional single model predictions, the proposed method consistently demonstrated higher accuracy. These results indicate that the proposed approach effectively adapts to data distribution shifts in operational environments where ground-truth data is unavailable. en-copyright= kn-copyright= en-aut-name=FurukawaKento en-aut-sei=Furukawa en-aut-mei=Kento kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakagawaHiroyuki en-aut-sei=Nakagawa en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsuchiyaTatsuhiro en-aut-sei=Tsuchiya en-aut-mei=Tatsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Information Science and Technology, Osaka University kn-affil= affil-num=2 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Information Science and Technology, Osaka University kn-affil= en-keyword=Self-adaptive systems kn-keyword=Self-adaptive systems en-keyword=frameworks kn-keyword=frameworks en-keyword=machine learning kn-keyword=machine learning END start-ver=1.4 cd-journal=joma no-vol=135 cd-vols= no-issue= article-no= start-page=103134 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202605 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Regulation of brain-specific kinases 1 and 2 (BRSK1/2) by Ca2+/calmodulin en-subtitle= kn-subtitle= en-abstract= kn-abstract=We conducted a genome-wide calmodulin (CaM) interaction screening of 462 GST-fused human protein kinases to identify novel CaM-dependent protein kinases (CaMKs). In addition to known CaMKs, including myosin light chain kinases, CaMK2ƒÁ, and death-associated kinase 2, we identified the brain-specific protein kinase 2 (BRSK2, also known as SAD-A) as a novel CaM interactant. Proximity biotinylation and CaM?sepharose chromatography assays revealed that rat BRSK isoforms (BRSK1/2) interact with CaM in a Ca2+-dependent manner in vitro. We found that CaM suppresses the activation-loop phosphorylation of BRSK1 (at Thr189) and BRSK2 (at Thr175) by liver kinase B1 (LKB1), an activating kinase, in a Ca2+-dependent manner (IC50 of ?7 ?M), thereby inhibiting BRSK activation. LKB1-catalyzed phosphorylation of the catalytic domain mutant of BRSK1 (residues 1?294) at Thr189 was suppressed by the addition of Ca2+/CaM, consistent with direct CaM binding of the kinase domain, as well as wild-type BRSK1. We confirmed that the LKB1 activity was not directly suppressed by Ca2+/CaM, supporting the hypothesis that the direct interaction of Ca2+/CaM with the kinase domain blocks the phosphorylation/activation of BRSK1/2 by LKB1. The kinase activity and PP2Cƒ¿-catalyzed dephosphorylation of LKB1-phosphorylated BRSK1 were not altered by Ca2+/CaM, although it was demonstrated to bind to Ca2+/CaM like that of unphosphorylated BRSK1. This unrecognized mechanism of BRSK1/2 regulation, involving the direct role of Ca2+/CaM binding, which inhibits phosphorylation/activation by LKB1, may open a new Ca2+ signal transduction pathway in neurons. en-copyright= kn-copyright= en-aut-name=WashidaNaoyuki en-aut-sei=Washida en-aut-mei=Naoyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KataokaMoe en-aut-sei=Kataoka en-aut-mei=Moe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=BrunAnna R. en-aut-sei=Brun en-aut-mei=Anna R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakezakiUryu en-aut-sei=Takezaki en-aut-mei=Uryu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HijikawaKo en-aut-sei=Hijikawa en-aut-mei=Ko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamauchiHaruki en-aut-sei=Yamauchi en-aut-mei=Haruki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OhtsukaSatomi en-aut-sei=Ohtsuka en-aut-mei=Satomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MagariMasaki en-aut-sei=Magari en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MorishitaRyo en-aut-sei=Morishita en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TokumitsuHiroshi en-aut-sei=Tokumitsu en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil=Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Okayama University kn-affil= affil-num=3 en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=4 en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=5 en-affil=Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Okayama University kn-affil= affil-num=6 en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=7 en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=8 en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=9 en-affil=CellFree Sciences Co., Ltd. kn-affil= affil-num=10 en-affil=Applied Cell Biology, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= en-keyword=BRSK1 kn-keyword=BRSK1 en-keyword=BRSK2 kn-keyword=BRSK2 en-keyword=calmodulin kn-keyword=calmodulin en-keyword=LKB1 kn-keyword=LKB1 en-keyword=phosphorylation kn-keyword=phosphorylation en-keyword=Ca2+ kn-keyword=Ca2+ en-keyword=CaM-dependent protein kinase kn-keyword=CaM-dependent protein kinase END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue= article-no= start-page=1806 end-page=1810 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202605 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=An electric field temporarily strengthens zirconia ceramics en-subtitle= kn-subtitle= en-abstract= kn-abstract=By applying an electric field to yttria-stabilized zirconia (8YSZ) equipped with an inert electrode, oxide ions are localized near the positive electrode, causing it to expand. When polarization was performed under different conditions, it was possible to strengthen the material to 1.5 times that of an untreated sample. The lattice constant of the positive electrode surface after polarization was larger than before polarization. When the Vickers hardness of the positive electrode surface was measured by changing the test load, the smaller the load, the higher the hardness value. Polarization caused oxide ions to move near the positive electrode, filling in the defects and generating an expanded layer with a large lattice constant. It is believed that this was subjected to compressive stress from the bulk layer, which had not changed in volume, resulting in an increase in strength. en-copyright= kn-copyright= en-aut-name=KishimotoAkira en-aut-sei=Kishimoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimizuTakahiro en-aut-sei=Shimizu en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NishiyamaMitsuru en-aut-sei=Nishiyama en-aut-mei=Mitsuru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KondoShinya en-aut-sei=Kondo en-aut-mei=Shinya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TeranishiTakashi en-aut-sei=Teranishi en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=5 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Poling kn-keyword=Poling en-keyword=Zirconia ceramics kn-keyword=Zirconia ceramics en-keyword=Strengthening kn-keyword=Strengthening en-keyword=Internal stress kn-keyword=Internal stress END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=1 article-no= start-page=269 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=From localized 4f electrons to anisotropic exchange interactions in ferromagnetic CeRh6Ge4 en-subtitle= kn-subtitle= en-abstract= kn-abstract=CeRh6Ge4 is a cerium-based ferromagnetic material exhibiting a quantum critical behavior under pressure. We derive effective exchange interactions, using the framework of density functional theory combined with dynamical mean-field theory. Our results reveal that the nearest-neighbor ferromagnetic interaction along the c axis is isotropic in spin space, leading to a formation of spin chains. On the other hand, the inter-chain coupling is highly anisotropic: The in-plane moment weakly interacts ferromagnetically in the a?b plane to stabilize the ferromagnetic state, whereas the z-component couples antiferromagnetically, contributing to its destabilization. The magnetic anisotropy of the interchain interactions as well as of the local 4f wavefunctions characterizes the magnetic properties underlying the ferromagnetic transition and the quantum critical behavior in CeRh6Ge4. en-copyright= kn-copyright= en-aut-name=ItokazuShoichiro en-aut-sei=Itokazu en-aut-mei=Shoichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KirikoshiAkimitsu en-aut-sei=Kirikoshi en-aut-mei=Akimitsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=JeschkeHarald O. en-aut-sei=Jeschke en-aut-mei=Harald O. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OtsukiJunya en-aut-sei=Otsuki en-aut-mei=Junya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Physics, Okayama University kn-affil= affil-num=2 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=753 end-page=754 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=–@Šw‰ïŽGŽ‘掵ŒÜŠªi’ÊŠªŽ©‘æ“ñ˜ZZ†@ŽŠ‘æ“ñ˜Z“ñ†j‘–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=751 end-page=751 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw–@Šw•”E–@Šw‰ï—ߘa‚V”N“xu‰‰‰ï‘S‹L˜^ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=743 end-page=749 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=²“¡@Œá˜Y‹³Žö@—ª—ð en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=737 end-page=741 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‹g–ì@‰ÄŒÈ‹³Žö@—ª—ð en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=729 end-page=735 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ÍŒ´@—S”n‹³Žö@—ª—ð en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=727 end-page=727 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=–{†Ž·•MŽÒЉî en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=438 end-page=410 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on Water Pollution by Persistent Organic PollutantsiPFOSEPFOAj: Focused on Duty of Care in Transactions. kn-title=PFOSEPFOA “™‚ÌŽc—¯«—L‹@‰˜õ•¨Ž¿‚É‚æ‚é…Ž¿‰˜õ‚ÉŠÖ‚·‚éˆêlŽ@ \ Žæˆøã‚Ì‹`–±‚ÌŽ‹“_‚©‚ç\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TsujiH. en-aut-sei=Tsuji en-aut-mei=H. kn-aut-name=’Ò”Ž–¾ kn-aut-sei=’Ò kn-aut-mei=”Ž–¾ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw–¼—_‹³Žö END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=456 end-page=439 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Suizidteilnahme und Einwilligung zum Mord kn-title=Ž©ŽEŠÖ—^‚Æ“¯ˆÓŽEl en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShiotaniT. en-aut-sei=Shiotani en-aut-mei=T. kn-aut-name=‰–’J‹B kn-aut-sei=‰–’J kn-aut-mei=‹B aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=586 end-page=496 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Possibility of a Japanese Approach to Standards of Judicial Review kn-title=“ú–{“ÆŽ©‚̈ጛR¸Šî€˜_‚̉”\« en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ItoT. en-aut-sei=Ito en-aut-mei=T. kn-aut-name=ˆÉ“¡Œ’ kn-aut-sei=ˆÉ“¡ kn-aut-mei=Œ’ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=656 end-page=588 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Le contrat social dans la D?claration des droits de lfhomme et du citoyen de 1789 kn-title=1789”Nƒtƒ‰ƒ“ƒXlŒ éŒ¾‚ƎЉïŒ_–ñ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HatanoS. en-aut-sei=Hatano en-aut-mei=S. kn-aut-name=”g‘½–ì•q kn-aut-sei=”g‘½–ì kn-aut-mei=•q aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw–¼—_‹³Žö END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=706 end-page=657 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Development and Present State of Judicial Doctrine on the Speedy Trial Clause kn-title=v‘¬Ù”»ð€‚ÉŠÖ‚·‚é”»—á–@—‚Ì“WŠJ‚ÆŒ»ó en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HaradaK. en-aut-sei=Harada en-aut-mei=K. kn-aut-name=Œ´“c˜a‰ kn-aut-sei=Œ´“c kn-aut-mei=˜a‰ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=726 end-page=707 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on the Consequences of Invalid Election Results under Article 251 of the Public Offices Election Act kn-title=ŒöE‘I‹“–@251ði“–‘Il–{l‚Ì‘I‹“”Æßj‚É‚æ‚é“–‘I–³Œø‚ÌŒ‹‰Ê‚ÉŠÖ‚·‚éˆêlŽ@ \ ÅŽO¬”»—ߘa‚T”N12ŒŽ12“ú–¯W77Šª‚X†2229•Å‚ðŒ_‹@‚Æ‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FukushigeS. en-aut-sei=Fukushige en-aut-mei=S. kn-aut-name=•Ÿd‚³‚ÆŽq kn-aut-sei=•Ÿd kn-aut-mei=‚³‚ÆŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=371 end-page=407 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On F. Michelmanfs Interpretation of Rawlsfs Later Thought: An Examination of Its Republican Implications kn-title=‚eEƒ}ƒCƒPƒ‹ƒ}ƒ“‚ÌŒãŠúƒ[ƒ‹ƒY‰ðŽß‚ɂ‚¢‚Ä \‚»‚Ì‹¤˜aŽå‹`“IŠÜˆÓ‚ÌŒŸ“¢ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OmoriH. en-aut-sei=Omori en-aut-mei=H. kn-aut-name=‘åXGb kn-aut-sei=‘åX kn-aut-mei=Gb aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page=349 end-page=370 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Liberalism and Moral Psychology: Jonathan Haidt and John Rawls kn-title=ƒŠƒxƒ‰ƒŠƒYƒ€‚Æ“¹“¿S—Šw \ƒWƒ‡ƒiƒTƒ“EƒnƒCƒg‚ƃWƒ‡ƒ“Eƒ[ƒ‹ƒY en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OdagawaD. en-aut-sei=Odagawa en-aut-mei=D. kn-aut-name=¬“cì‘å“T kn-aut-sei=¬“cì kn-aut-mei=‘å“T aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=75 cd-vols= no-issue=3-4 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³ˆç„i‹@\ ‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[Œ´eŽ·•M—v—Ì en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³ˆç„i‹@\ ‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[‚ÌŠˆ“®ó‹µ‚ÌŠT—v en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=253 end-page=266 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=How Can School Counselors Contribute to Developmentally Supportive Student Guidance: An Examination of Support Expansion Through the Use of Planning Sheets kn-title=ƒXƒN[ƒ‹ƒJƒEƒ“ƒZƒ‰[‚Í”­’BŽxŽ“I¶“kŽw“±‚Ö‚¢‚©‚ÉvŒ£‚Å‚«‚é‚© \ƒvƒ‰ƒ“ƒjƒ“ƒOƒV[ƒg‚ÌŠˆ—p‚ð’Ê‚µ‚½Žx‰‡‚ÌŠg[‚ÉŒü‚¯‚½ŒŸ“¢\ en-subtitle= kn-subtitle= en-abstract=@In the revised Guidelines for Student Guidance (2022), the importance of developmentally supportive student guidance, which aims to foster the growth of all students, is clearly emphasized. However, many challenges to its implementation have been identified in school settings, including teachersf excessive workload and insufficient organizational support systems. Moreover, the support provided by school counselors (SCs) has not yet been sufficiently developed. Therefore, this study examined the potential for expanding SCsf support in developmentally supportive student guidance by reviewing its current status and challenges. Furthermore, through a reanalysis of a practical case using the Planning Sheet (Hara et al., 2024), the study explored the usefulness of this framework in enabling SCs and schools to share educational goals and collaboratively plan their support activities. kn-abstract=@2022”N‚ɉü’ù‚³‚ꂽu¶“kŽw“±’ñ—vv‚Å‚ÍC‚·‚ׂĂ̎™“¶¶“k‚̬’·‚ðŽx‰‡‚·‚é”­’BŽxŽ“I¶“kŽw“±‚Ìd—v«‚ª–¾Šm‚ÉŽ¦‚³‚ê‚Ä‚¢‚éB‚µ‚©‚µC‚»‚Ì’è’…‚É‚ÍC‹³ˆõ‚Ì‘½–Z‰»‚â‘gD“IŽx‰‡‘̧‚Ì•s\•ª‚³‚È‚ÇCŠwZŒ»ê‚É‚¨‚¯‚鑽‚­‚̉ۑ肪Žw“E‚³‚ê‚Ä‚¢‚éB‚³‚ç‚ÉCƒXƒN[ƒ‹ƒJƒEƒ“ƒZƒ‰[iSCj‚É‚æ‚éŽx‰‡‚à\•ª‚É“WŠJ‚³‚ê‚Ä‚¢‚é‚Æ‚ÍŒ¾‚¢“ï‚¢B‚»‚±‚Å–{e‚Å‚ÍC”­’BŽxŽ“I¶“kŽw“±‚É‚¨‚¯‚éSC‚ÌŽx‰‡‚ÌŠg[‰Â”\«‚ðŒŸ“¢‚·‚邽‚ßCŒ»ó‚Ɖۑè‚ð®—‚µ‚½B‚Ü‚½Cƒvƒ‰ƒ“ƒjƒ“ƒOƒV[ƒg‚ðŠˆ—p‚µ‚½ŽÀ‘HŽ–—áiŒ´‘¼, 2024j‚ÌÄ•ªÍ‚ð’Ê‚µ‚ÄCSC‚ÆŠwZ‚ª‹³ˆç–Ú•W‚ð‹¤—L‚µ‚È‚ª‚狦“­“I‚ÉŽx‰‡‚ðŒv‰æ‚·‚é˜g‘g‚Ý‚Ì—L—p«‚ð‹á–¡‚µ‚½B en-copyright= kn-copyright= en-aut-name=HARANoriyuki en-aut-sei=HARA en-aut-mei=Noriyuki kn-aut-name=Œ´”ÍK kn-aut-sei=Œ´ kn-aut-mei=”ÍK aut-affil-num=1 ORCID= en-aut-name=MISAWARyo en-aut-sei=MISAWA en-aut-mei=Ryo kn-aut-name=ŽO‘ò—Ç kn-aut-sei=ŽO‘ò kn-aut-mei=—Ç aut-affil-num=2 ORCID= en-aut-name=AOKITazuko en-aut-sei=AOKI en-aut-mei=Tazuko kn-aut-name=–ؑ½ŽõŽq kn-aut-sei=Â–Ø kn-aut-mei=‘½ŽõŽq aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRŒ§Œö—§ŠwZƒXƒN[ƒ‹ƒJƒEƒ“ƒZƒ‰[ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=”­’BŽxŽ“I¶“kŽw“± (developmentally supportive student guidance) kn-keyword=”­’BŽxŽ“I¶“kŽw“± (developmentally supportive student guidance) en-keyword=ƒvƒ‰ƒ“ƒjƒ“ƒOƒV[ƒg (Planning Sheet) kn-keyword=ƒvƒ‰ƒ“ƒjƒ“ƒOƒV[ƒg (Planning Sheet) en-keyword=ƒXƒN[ƒ‹ƒJƒEƒ“ƒZƒ‰[ (school counselor) kn-keyword=ƒXƒN[ƒ‹ƒJƒEƒ“ƒZƒ‰[ (school counselor) en-keyword=ƒ`[ƒ€ŠwZ (school as a team) kn-keyword=ƒ`[ƒ€ŠwZ (school as a team) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=237 end-page=251 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Preliminary Consideration on the Introduction of Philosophical Thinking into Special Needs Education: A Methodological Framework Based on the Concepts of Duration, Becoming, and Diffraction kn-title=“Á•ÊŽx‰‡‹³ˆç‚Ö‚Ì“NŠw“IŽvl“±“ü‚ɂ‚¢‚Ä‚Ì—\”õ“IlŽ@ Ž‘±E¶¬•Ï‰»E‰ñÜ‚Ìl‚¦•û‚ÉŠî‚­•û–@“I˜g‘g‚Ý‚ÌŽŽˆÄ en-subtitle= kn-subtitle= en-abstract=This paper presents a theoretical and methodological examination aimed at introducing philosophical thinking into the practice of special needs education in response to contemporary challenges in the field. As its theoretical foundation, the study outlines Bergsonf s theory of memory, Deleuze and Guattarif s philosophy of becoming, Baradf s diffractive methodology, and Blomf s diffractive ethnography. Building upon these theories, it proposes a methodological framework that adopts three interrelated analytical perspectives?gmaterial-discursive practices,h gduration,h and gbecomingh?for reading and interpreting educational practices. These perspectives, situated within the paradigm of post-qualitative research, make it possible to understand educational events as relational and processual phenomena rather than fixed outcomes. Future issues include the theoretical integration of the three lenses, clarification of the distinctions between diffractive methodology and diffractive ethnography, and refinement of analytical methods for connecting multiple practice episodes. kn-abstract=@–{e‚ÍCŒ»‘ã‚Ì“Á•ÊŽx‰‡‹³ˆç‚̉ۑ肩‚çC“Á•ÊŽx‰‡‹³ˆçŽÀ‘H‚É“NŠw“IŽvl‚𓱓ü‚·‚邽‚ß‚Ì—˜_“IE•û–@“IŒŸ“¢‚ðs‚¤‚à‚Ì‚Å‚ ‚éB‚Ü‚¸C—˜_Šî”Õ‚Æ‚µ‚ÄCƒxƒ‹ƒNƒ\ƒ“‚Ìu‹L‰¯—˜_vCƒhƒDƒ‹[ƒY•ƒKƒ^ƒŠ‚Ìu¶¬•Ï‰»‚Ì“NŠwvCBarad‚Ìu‰ñÜ“I•û–@˜_vCBlom‚Ìu‰ñÜ“IƒGƒXƒmƒOƒ‰ƒtƒB[v‚ɂ‚¢‚ÄŠTà‚µ‚½B‚»‚µ‚ÄC—˜_Šî”Õ‚ðŠî‚É•û–@“I˜g‘g‚Ý‚Æ‚µ‚ÄCu•¨Ž¿|Œ¾à“IŽÀ‘HvCuŽ‘±vCu¶¬•Ï‰»v‚ÌŽO‚‚̎‹“_‚ð‹³ˆçŽÀ‘H‚ð“Ç‚Ý‰ð‚­‚½‚ß‚Ì‘ŠŒÝ•âŠ®“I‚È•ªÍŽ‹“_‚Æ‚µ‚ÄÌ—p‚·‚邱‚Æ‚ð’ñˆÄ‚µ‚½B‚±‚ê‚ç‚ÌŽ‹“_‚ÍCƒ|ƒXƒgŽ¿“IŒ¤‹†‚Æ‚µ‚ÄCo—ˆŽ–‚ðŠÖŒW“IE‰ß’ö“I‚É‘¨‚¦‚邱‚Æ‚ð‰Â”\‚É‚·‚é‚à‚Ì‚Å‚ ‚éB¡Œã‚̉ۑè‚Æ‚µ‚ÄCŽO‚‚̃Œƒ“ƒYŠÔ‚Ì—˜_“I®—C‰ñÜ“I•û–@˜_‚ƉñÜ“IƒGƒXƒmƒOƒ‰ƒtƒB[‚Ì·ˆÙ‰»C‚¨‚æ‚Ñ•¡”‚ÌŽÀ‘HƒGƒsƒ\[ƒh‚ðÚ‘±‚µ‚Ä•`‚­‚½‚ß‚Ì•ªÍŽè–@‚̸ãk‰»‚ª‹“‚°‚ç‚ꂽB en-copyright= kn-copyright= en-aut-name=HAMADAYo en-aut-sei=HAMADA en-aut-mei=Yo kn-aut-name=ûM“c—j kn-aut-sei=ûM“c kn-aut-mei=—j aut-affil-num=1 ORCID= en-aut-name=TAKANOMiyuki en-aut-sei=TAKANO en-aut-mei=Miyuki kn-aut-name=ûü–ì”ü—R‹I kn-aut-sei=ûü–ì kn-aut-mei=”ü—R‹I aut-affil-num=2 ORCID= en-aut-name=SATOSatoru en-aut-sei=SATO en-aut-mei=Satoru kn-aut-name=²“¡ú kn-aut-sei=²“¡ kn-aut-mei=ú aut-affil-num=3 ORCID= affil-num=1 en-affil=Okayama Prefectural Okayama Seto Special Needs School kn-affil=‰ªŽRŒ§—§‰ªŽR£ŒË‚“™Žx‰‡ŠwZ affil-num=2 en-affil=Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@ affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=“Á•ÊŽx‰‡‹³ˆç (special needs education) kn-keyword=“Á•ÊŽx‰‡‹³ˆç (special needs education) en-keyword=“NŠw (philosophy) kn-keyword=“NŠw (philosophy) en-keyword=•ªÍŽ‹“_ (analytical perspectives) kn-keyword=•ªÍŽ‹“_ (analytical perspectives) en-keyword=ƒ|ƒXƒgƒqƒ…[ƒ}ƒjƒYƒ€ (posthumanism) kn-keyword=ƒ|ƒXƒgƒqƒ…[ƒ}ƒjƒYƒ€ (posthumanism) en-keyword=Ž¿“IŒ¤‹† (qualitative research) kn-keyword=Ž¿“IŒ¤‹† (qualitative research) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=221 end-page=235 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Designing an Educational Model and Assessing Outcomes for the Graduate Course gLeadership and SDGsh New Directions in Leadership Education through Theory Learning, Peer Review, and Reflective Practice kn-title=‘åŠw‰@‹¤’ʉȖÚwƒŠ[ƒ_[ƒVƒbƒv‚ÆSDGsx‚Ì‹³ˆçƒ‚ƒfƒ‹\’z‚Ƭ‰Ê•ªÍ —˜_ŠwKEƒsƒAƒŒƒrƒ…[EÈŽ@Šˆ“®‚É‚æ‚郊[ƒ_[ƒVƒbƒv‹³ˆç‚ÌV“WŠJ en-subtitle= kn-subtitle= en-abstract=Okayama University's graduate school has developed and implemented a core course, gLeadership and SDGs,h to foster leadership among graduate students. The course focuses on the development of leaders who can contribute to the achievement of the SDGs (Sustainable Development Goals) and combines theoretical study, peer review, reflective practice, and group discussion to encourage mutual learning and self-growth among students. By analyzing learning outcomes across different departments, the study demonstrates that reflective, theory-based learning and collaborative critique activities effectively deepen leadership understanding and personal development. This research clarifies the significance of building and continuously improving an educational model that integrates academic theory and practical activities. kn-abstract=@‰ªŽR‘åŠw‘åŠw‰@‚Å‚ÍA”ŽŽm‰Û’ölނ̃Š[ƒ_[ƒVƒbƒvˆç¬‚ÉŒü‚¯A‹¤’ʉȖÚwƒŠ[ƒ_[ƒVƒbƒv‚ÆSDGsx‚ðÝŒvEŽÀ‘H‚µ‚Ä‚¢‚éB–{‰È–Ú‚ÍSDGs‚ÉvŒ£‚·‚郊[ƒ_[ˆç¬‚ÉŽåŠá‚ð’u‚«A—˜_ŠwKEƒsƒAƒŒƒrƒ…[EÈŽ@EƒOƒ‹[ƒvƒfƒBƒXƒJƒbƒVƒ‡ƒ““™‚ÌŽè–@‚ð‘g‚݇‚킹AŠw¶“¯Žm‚ÌŠw‚ч‚¢EŽ©ŒÈ¬’·‚Ì‘£i‚ð–Ú“I‚Æ‚µ‚Ä‚¢‚éB–{e‚Å‚ÍAŠw•”EŒ¤‹†‰È‚²‚Æ‚ÉŠwK¬‰Ê‚ð•ªÍ‚µA—˜_‚ÉŠî‚­Ȏ@“IŠw‚Ñ‚Æ‹¦“­“I‚È”á•]Šˆ“®‚ªƒŠ[ƒ_[ƒVƒbƒv—‰ð‚⬒·‚É—L—p‚Å‚ ‚邱‚Ƃ𖾂炩‚É‚µ‚½B–{Œ¤‹†‚ÍAŠwp“I—˜_‚ÆŽÀ‘H“IŠˆ“®‚ðD‚èŒð‚º‚½ƒ‚ƒfƒ‹\’z‚ÆA‚»‚ÌŒp‘±“I‰ü‘P‚̈Ӌ`‚ðŽ¦‚µ‚Ä‚¢‚éB en-copyright= kn-copyright= en-aut-name=ISHIDAMamoru en-aut-sei=ISHIDA en-aut-mei=Mamoru kn-aut-name=Γc‰q kn-aut-sei=Γc kn-aut-mei=‰q aut-affil-num=1 ORCID= en-aut-name=OTSUNEShinichi en-aut-sei=OTSUNE en-aut-mei=Shinichi kn-aut-name=‘åí^ˆê kn-aut-sei=‘åí kn-aut-mei=^ˆê aut-affil-num=2 ORCID= en-aut-name=NAKAZAWATakuya en-aut-sei=NAKAZAWA en-aut-mei=Takuya kn-aut-name=’†àV‘ñ–ç kn-aut-sei=’†àV kn-aut-mei=‘ñ–ç aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of General Education and Global Studies, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹¤’Ê‹³ˆçEƒOƒ[ƒoƒ‹—̈æ affil-num=2 en-affil=Graduate student, Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŒ¤‹†‰È affil-num=3 en-affil=Graduate student, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†‰È en-keyword=ƒŠ[ƒ_[ƒVƒbƒv‹³ˆç (Leadership Education) kn-keyword=ƒŠ[ƒ_[ƒVƒbƒv‹³ˆç (Leadership Education) en-keyword=ŠwKÝŒv (Learning Design) kn-keyword=ŠwKÝŒv (Learning Design) en-keyword=‚“™‹³ˆç (Higher Education) kn-keyword=‚“™‹³ˆç (Higher Education) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=205 end-page=219 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Tier 1 Support of School-Wide Positive Behavior Support (SWPBS) in the High School Division of a Special Needs School for Students with Intellectual Disabilities: Implementation and Effects of a Campaign-Based Approach kn-title=’m“IáŠQ‚“™“Á•ÊŽx‰‡ŠwZ‚É‚¨‚¯‚é SWPBS ‘æ‚P‘wŽx‰‡ \ƒLƒƒƒ“ƒy[ƒ“•ûŽ®‚Ì“±“ü‚Æ‚»‚ÌŒø‰Ê\ en-subtitle= kn-subtitle= en-abstract=This study examined the effects of a campaign-based intervention implemented as Tier 1 support within School-Wide Positive Behavior Support (SWPBS). It took place at a public upper secondary school for students with mild intellectual disabilities. A gThank-You Campaignh was conducted with 24 students in one grade level. The frequency of predefined target behaviors was analyzed using AB design with follow-ups. A social validity questionnaire was also administered to six teachers of the same grade. Results showed that both the frequency of the target behaviors and the percentage of students engaging in those behaviors increased after the campaign. These increases remained above baseline levels for a certain period after the campaign ended. The intervention also demonstrated a moderate degree of social validity. These findings suggest that campaign-based approaches can be a useful form of Tier 1 support in SWPBS for students with mild intellectual disabilities at the upper secondary level. kn-abstract=@–{Œ¤‹†‚ÍCŒy“x’m“IáŠQ‚Ì‚ ‚éŒãŠú’†“™‹³ˆç’iŠK‚ÌŒö—§’m“IáŠQ‚“™“Á•ÊŽx‰‡ŠwZ‚É‚¨‚¢‚ÄCSWPBS ‘æ1‘wŽx‰‡‚Æ‚µ‚ăLƒƒƒ“ƒy[ƒ“•ûŽ®‚ÌŽx‰‡‚ðŽÀŽ{‚µC‚»‚ÌŒø‰ÊŒŸØ‚ðs‚Á‚½B•û–@‚Æ‚µ‚Ä‚ÍC‚wŠw”N¶“k24–¼‚ɑ΂µ‚Ĉ¥ŽAs“®‚Ì‘£i‚ð‘_‚Á‚½ƒLƒƒƒ“ƒy[ƒ“‚ðŽÀŽ{‚µC–Ú•Ws“®‚̶‹N”‚ɂ‚¢‚ÄABƒtƒHƒ[ƒAƒbƒvƒfƒUƒCƒ“‚ð—p‚¢‚ÄŒŸ“¢‚µ‚½B‚Ü‚½C‚wŠw”N‹³ˆõ6–¼‚ɑ΂µCŽÐ‰ï“I‘Ó–«‚ð•]‰¿‚·‚éƒAƒ“ƒP[ƒg‚ðŽÀŽ{‚µ‚½B‚»‚ÌŒ‹‰ÊCƒLƒƒƒ“ƒy[ƒ“‚̉î“ü’¼Œã‚É–Ú•Ws“®‚̶‹N”‚¨‚æ‚Ñ–Ú•Ws“®‚É]Ž–‚µ‚½¶“k‚ÌŠ„‡‚Ì‘‰Á‚ªŒ©‚ç‚êCƒLƒƒƒ“ƒy[ƒ“I—¹Œã‚àƒx[ƒXƒ‰ƒCƒ“‚Æ”äŠr‚µ‚½‘‰Á‚ªˆê’èŠúŠÔŠm”F‚³‚ꂽB‚Ü‚½Cˆê’è’ö“x‚̎Љï“I‘Ó–«‚àŠm”F‚Å‚«‚½B en-copyright= kn-copyright= en-aut-name=TOKIMITSUHideaki en-aut-sei=TOKIMITSU en-aut-mei=Hideaki kn-aut-name=ŽžŒõG–¾ kn-aut-sei=ŽžŒõ kn-aut-mei=G–¾ aut-affil-num=1 ORCID= en-aut-name=MIYAZAKIYoshio en-aut-sei=MIYAZAKI en-aut-mei=Yoshio kn-aut-name=‹{ú±‘P˜Y kn-aut-sei=‹{ú± kn-aut-mei=‘P˜Y aut-affil-num=2 ORCID= en-aut-name=KOYAMAMadoka en-aut-sei=KOYAMA en-aut-mei=Madoka kn-aut-name=¬ŽR‰~ kn-aut-sei=¬ŽR kn-aut-mei=‰~ aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Course), Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Kurashiki Kotoura Special Needs Seni or High School, Okayama Prefecture kn-affil=‰ªŽRŒ§—§‘q•~‹Õ‰Y‚“™Žx‰‡ŠwZ en-keyword=‚“™•” (High school division) kn-keyword=‚“™•” (High school division) en-keyword=Œy“x’m“IáŠQ (Mild intellectual disabilities) kn-keyword=Œy“x’m“IáŠQ (Mild intellectual disabilities) en-keyword=SWPBSiŠwZ‹K–̓|ƒWƒeƒBƒus“®Žx‰‡j(School-Wide Positive Behavior Support (SWPBS)) kn-keyword=SWPBSiŠwZ‹K–̓|ƒWƒeƒBƒus“®Žx‰‡j(School-Wide Positive Behavior Support (SWPBS)) en-keyword=‘æ1‘wŽx‰‡ (Tier 1 support) kn-keyword=‘æ1‘wŽx‰‡ (Tier 1 support) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=191 end-page=203 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Examining a Practical Case of Learning for Community Development ?Focusing on the Changes in Awareness of Junior High School Students During Integrated Studies? kn-title=’¬‚­‚è‚ðl‚¦‚éŽÀ‘HŽ–—á‚ÌŒŸ“¢ \‘‡“I‚ÈŠwK‚ÌŽžŠÔ‚ð’Ê‚¶‚½’†Šw¶‚̈ӎ¯•Ï‰»‚É’…–Ú‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= This study aims to clarify the effects of junior high school students planning community development through collaboration and interaction with others, and the changes in learners that arise from the results of such practice. It also examines how interactions with others, which are emphasized in dialogic learning, can be applied to junior high school practice and what form this should take. The goal of this practice is to foster a change in students' awareness of their town by having them interpret the future and nature of the town from various perspectives in relation to their interactions with others, and consider sustainable ways of living in the town and forming relationships as their own concern. As a result of the practice, students experienced changes in their perspectives and awareness regarding the town and were able to think about the regional issues involved in town development as their own concern. kn-abstract=@–{Œ¤‹†‚ÍC’†ŠwZ‘‡“I‚ÈŠwK‚ÌŽžŠÔ‚É‚¨‚¯‚é’¬‚­‚è‚É‚¨‚¢‚ÄC‘¼ŽÒ‚Æ‚Ì‹¦“­‚â‘ŠŒÝì—p‚ð’Ê‚¶‚Ä’¬‚­‚è‚ð\‘z‚µCŽÀ‘H‚ÌŒ‹‰Ê¶‚¶‚½ŠwKŽÒ‚̕ω»‚©‚ç‚»‚ÌŒø‰Ê‚𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚Ä‚¢‚éB‚Ü‚½C‘Θb“I‚ÈŠw‚Ñ‚ÅdŽ‹‚³‚ê‚鑼ŽÒ‚Æ‚Ì‘ŠŒÝì—p‚ðC’†ŠwZ‚ÌŽÀ‘H‚É—Ž‚Æ‚µž‚ÝC‚»‚Ì‚ ‚è•û‚ɂ‚¢‚Ä‚àŒŸ“¢‚·‚éB–{ŽÀ‘H‚Ì‚Ë‚ç‚¢‚ÍC‘½—l‚ÈŽ‹“_‚©‚ç’¬‚Ì«—ˆ‚ÌŽp‚â‚ ‚è•û‚ðl‚Æ‚ÌŠÖ‚í‚è‚ɂ‚¢‚ēǂ݉ð‚«CŽ‘±‰Â”\‚È’¬‚Ì‚ ‚è•û‚ɂ‚¢‚ÄŽ©•ªŽ–‚Ɉø‚«Šñ‚¹‚Äl‚¦‚邱‚Æ‚ÅC’¬‚ɑ΂·‚éˆÓŽ¯‚̕ω»‚𑣂·‚±‚Æ‚É‚ ‚éBŽÀ‘H‚ÌŒ‹‰ÊCŠwKŽÒ‚Ì’¬‚ɑ΂·‚錩•û‚âl‚¦•û‚̈ӎ¯•Ï‰»‚ªˆø‚«‹N‚±‚³‚êC’¬‚­‚è‚ÌŽ‚Â’nˆæ‰Û‘è‚ɂ‚¢‚ÄŽ©•ªŽ–‚Ɉø‚«Šñ‚¹‚ÄŽvl‚·‚邱‚Æ‚ª‚Å‚«‚½B en-copyright= kn-copyright= en-aut-name=KAMADAAkemi en-aut-sei=KAMADA en-aut-mei=Akemi kn-aut-name=Š™“c–¾”ü kn-aut-sei=Š™“c kn-aut-mei=–¾”ü aut-affil-num=1 ORCID= en-aut-name=KAJIIKazuaki en-aut-sei=KAJII en-aut-mei=Kazuaki kn-aut-name=Šˆäˆê‹Å kn-aut-sei=Šˆä kn-aut-mei=ˆê‹Å aut-affil-num=2 ORCID= affil-num=1 en-affil=Anan City Anan First Junior High School kn-affil=ˆ¢“ìŽs—§ˆ¢“ì‘æˆê’†ŠwZ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‘‡“I‚ÈŠwK‚ÌŽžŠÔ (the period for integrated studies) kn-keyword=‘‡“I‚ÈŠwK‚ÌŽžŠÔ (the period for integrated studies) en-keyword=’†Šw¶ (junior high school student) kn-keyword=’†Šw¶ (junior high school student) en-keyword=’¬‚­‚è (community development) kn-keyword=’¬‚­‚è (community development) en-keyword=‘Θb“I‚ÈŠw‚Ñ (int eractive lea rning) kn-keyword=‘Θb“I‚ÈŠw‚Ñ (int eractive lea rning) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=181 end-page=190 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practice and Challenges of Elementary School Moral Education Lessons Utilizing Self-Developed Teaching Materials on the Theme of eThe Dignity of Lifef kn-title=u¶–½‚Ì‘¸‚³v‚ÌŽ©ì‹³Þ‚ðŠˆ—p‚µ‚½¬ŠwZ“¹“¿‰ÈŽö‹Æ‚ÌŽÀ‘H‚Ɖۑè en-subtitle= kn-subtitle= en-abstract=This study investigated whether utilizing self-developed teaching materials for the moral content item "The Dignity of Life" could lead elementary school students to deeply reflect on the value of life in relation to their own experiences. The results confirmed that the use of these materials successfully enabled students to empathize with the characters and engage in deep reflection on the moral value of "The Dignity of Life" in a personal context. Conversely, a challenge emerged: due to the strength of the teacher's intent embedded in the original materials, students were occasionally observed tailoring their comments to align with the teacher's expectations. This suggests a potential, albeit unintentional, directionality imposed on student discourse by the instructor. Finally, this paper discusses the necessity of a continuous cycle of practice and reflection to realize truly student-centered moral education lessons. kn-abstract=@–{Œ¤‹†‚Å‚ÍC“à—e€–Úu¶–½‚Ì‘¸‚³v‚ÉŠÖ‚·‚鎩싳ނðŠJ”­‚µCŽö‹Æ‚ðŽÀŽ{‚·‚邱‚Æ‚É‚æ‚Á‚ÄCŽq‚Ç‚à‚ªu¶–½‚Ì‘¸‚³v‚ðŽ©•ª‚Æ‚ÌŠÖ‚í‚è‚Å[‚­l‚¦‚邱‚Æ‚ª‚Å‚«‚é‚©‚ɂ‚¢‚ÄŒŸØ‚µ‚½B¬‰Ê‚Æ‚µ‚ÄCŽ©ì‹³Þ‚ÌŠˆ—p‚É‚æ‚Á‚ÄŽq‚Ç‚à‚ª‹³Þ‚Ì“oêl•¨‚É‹¤Š´‚µCu¶–½‚Ì‘¸‚³v‚Ì“¹“¿“I‰¿’l‚ðŽ©•ª‚Æ‚ÌŠÖ‚í‚è‚Å[‚­l‚¦‚é—lŽq‚ªŠm”F‚Å‚«‚½Bˆê•ûC‰Û‘è‚Æ‚µ‚ÄCŽ©ì‹³Þ‚Öž‚ß‚½Žv‚¢‚Ì‹­‚³‚©‚çCŽq‚Ç‚à‚ªŽö‹ÆŽÒ‚̈Ó}‚ð‘g‚Ý‚È‚ª‚ç”­Œ¾‚·‚éŽp‚ªŒ©‚ç‚êCˆÓ}‚¹‚¸Žq‚Ç‚à‚Ì”­Œ¾‚ð•ûŒü•t‚¯‚½‰Â”\«‚ªŽ¦‚³‚ꂽBÅŒã‚ÉCŽq‚Ç‚à’†S‚ÌŽö‹Æ‚ÌŽÀŒ»‚ÉŒü‚¯‚ÄCŽÀ‘H‚ÆÈŽ@‚̉ŠÒ‚Ì•K—v«‚ɂ‚¢‚Ä‹c˜_‚µ‚½B en-copyright= kn-copyright= en-aut-name=YOSHIKAWAShinji en-aut-sei=YOSHIKAWA en-aut-mei=Shinji kn-aut-name=‹gìL“ñ kn-aut-sei=‹gì kn-aut-mei=L“ñ aut-affil-num=1 ORCID= en-aut-name=IZUMITsuguyuki en-aut-sei=IZUMI en-aut-mei=Tsuguyuki kn-aut-name=ˆÉZŒps kn-aut-sei=ˆÉZ kn-aut-mei=Œps aut-affil-num=2 ORCID= affil-num=1 en-affil=Tsurajimakita Elementary School kn-affil=‘q•~Žs—§˜A“‡–k¬ŠwZ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=“¹“¿‰È (Moral Education) kn-keyword=“¹“¿‰È (Moral Education) en-keyword=Ž©ì‹³Þ (Self-developed teaching materials) kn-keyword=Ž©ì‹³Þ (Self-developed teaching materials) en-keyword=¶–½‚Ì‘¸‚³ (The Dignity of Life) kn-keyword=¶–½‚Ì‘¸‚³ (The Dignity of Life) en-keyword=Ž™“¶ (Children) kn-keyword=Ž™“¶ (Children) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=167 end-page=180 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Developing High School Civics Lesson Plan Aimed at Improving Understanding of Constitutionalism: Depending on gWe the Peopleh of the Center for Civic Education kn-title=—§Œ›Žå‹`‚ɑ΂·‚é”FŽ¯‚̉ü‘P‚ð–ÚŽw‚µ‚½‚“™ŠwZŒö–¯‰È‚ÌŽö‹ÆŠJ”­Œ¤‹† \•Ä‘Œö–¯‹³ˆçƒZƒ“ƒ^[ŠJ”­w‰ä‚ç‡O‘l–¯x‚ðŽè‚ª‚©‚è‚É‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=This study aims to develop practicable lessons for high school civics classes that foster an understanding of constitutionalism as the foundation for grasping the Constitution. Traditional Japanese social studies education focused on understanding the Constitution's fundamental principles?popular sovereignty, respect for basic human rights, and pacifism. But, recently, the concept of constitutionalism has gained attention as a means to help students understand what a constitution fundamentally is, and it is now described in textbooks. This study proposes a lesson plan designed to help students appropriately grasp the concept of constitutionalism. In making the lesson plan, we referenced the long-used gWe the Peopleh program developed by the Center for Civic Education in U.S. We adapted materials originally created based on the historical context of the United States to fit the Japanese context, utilizing parts of this program. kn-abstract=@–{Œ¤‹†‚ÍAŒ›–@—‰ð‚ÌŠî–{‚Æ‚µ‚Ä‚Ì—§Œ›Žå‹`‚ɑ΂·‚é”FŽ¯Œ`¬‚ð–Ú•W‚Æ‚·‚éA‚“™ŠwZŒö–¯‰È‚ÅŽÀ‘H‰Â”\‚ÈŽö‹Æ‚ÌŠJ”­‚ð–ÚŽw‚µ‚½‚à‚Ì‚Å‚ ‚éB]—ˆ‚Ì“ú–{‚̎Љï‰È‹³ˆç‚É‚¨‚¢‚Ä‚ÍAŒ›–@—‰ð‚Í“ú–{‘Œ›–@‚ÌŠî–{Œ´‘¥‚Å‚ ‚é‘–¯ŽåŒ AŠî–{“IlŒ ‚Ì‘¸dA•½˜aŽå‹`‚Ì—‰ð‚ðŠî–{‚Æ‚µ‚Ä‚¢‚½‚ªA‹ß”NA‚»‚à‚»‚àŒ›–@‚Ƃ͉½‚©‚ð—‰ð‚³‚¹‚邽‚ß‚ÉA—§Œ›Žå‹`‚ÌŠT”O‚ª’–Ú‚³‚ê‚é‚悤‚É‚È‚èA‹³‰È‘‚É‚à‹Lq‚³‚ê‚Ä‚¢‚éB–{Œ¤‹†‚ÍA‚»‚̂悤‚È—§Œ›Žå‹`‚Æ‚¢‚¤ŠT”O‚ɂ‚¢‚Ķ“k‚É“KØ‚É—‰ð‚³‚¹‚邱‚Æ‚ð–ÚŽw‚µ‚½Žö‹Æ‚Ì’ñˆÄ‚ð‚µ‚æ‚¤‚Æ‚·‚é‚à‚Ì‚Å‚ ‚éBŽö‹ÆŒv‰æ쬂ɂ ‚½‚Á‚Ä‚ÍA•Ä‘‚ÌŒö–¯‹³ˆçƒZƒ“ƒ^[‚ªŠJ”­‚µA’·”NŠˆ—p‚³‚ê‚Ä‚¢‚éw‰ä‚ç‡O‘l–¯iŒ´‘è We the Peoplejx‚ðŽQÆ‚µA‚»‚̈ꕔ‚ðŠˆ—p‚µA•Ä‘‚Ì—ðŽj“I”wŒi‚ÉŠî‚¢‚Äì‚ç‚ꂽ‹³Þ‚ðA“ú–{‚Ì•¶–¬‚É‚»‚Á‚ĉü•Ï‚µ‚½B en-copyright= kn-copyright= en-aut-name=KUWABARAToshinori en-aut-sei=KUWABARA en-aut-mei=Toshinori kn-aut-name=ŒKŒ´•q“T kn-aut-sei=ŒKŒ´ kn-aut-mei=•q“T aut-affil-num=1 ORCID= en-aut-name=MIYAMOTOAyuha en-aut-sei=MIYAMOTO en-aut-mei=Ayuha kn-aut-name=‹{–{‚ ‚ä‚Í kn-aut-sei=‹{–{ kn-aut-mei=‚ ‚ä‚Í aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Graduate School of Humanities and Social Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»ŠwŒ¤‹†‰ÈŽÐ‰ï•¶‰»ŠwêU en-keyword=Žö‹ÆŠJ”­Œ¤‹† (Lesson Development Research) kn-keyword=Žö‹ÆŠJ”­Œ¤‹† (Lesson Development Research) en-keyword=Œö–¯‰È (Civic Education) kn-keyword=Œö–¯‰È (Civic Education) en-keyword=Œ›–@ŠwK (Constitutional Studies) kn-keyword=Œ›–@ŠwK (Constitutional Studies) en-keyword=—§Œ›Žå‹` (Constitutionalism) kn-keyword=—§Œ›Žå‹` (Constitutionalism) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=153 end-page=165 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Methods for Implementing Legal Education in Social Studies to Foster Understanding of Criminal Law Through Developing Junior High School Social Studies Lessons Incorporating Mock Trials kn-title=ŒY–@‚̈Ӌ`‚𑨂¦‚³‚¹‚éŽÐ‰ï‰È‚É‚¨‚¯‚é–@‹³ˆçŽÀ‘H‚Ì•û–@ \–Í‹[Ù”»‚ðŽæ‚è“ü‚ꂽ’†ŠwZŽÐ‰ï‰È‚ÌŽö‹ÆŠJ”­‚ð’Ê‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=This study focuses on developing junior high school social studies lessons incorporating mock trials to enhance understanding of criminal law. Legal education in Japanese social studies has traditionally centered on constitutional studies, with very few opportunities to learn about other laws. Given this situation, recent years have seen the development of legal education lessons covering civil law, criminal law, and other areas. Meanwhile, since the introduction of the lay judge system, the development and implementation of social studies lessons incorporating mock trials have become commonplace, and it is no longer unusual for criminal cases to be addressed in social studies classes. This study examines the characteristics and challenges of conventional mock trial-based lessons and aims to develop a junior high school social studies lesson that helps students grasp the significance of criminal law. kn-abstract=@–{Œ¤‹†‚ÍAŒY–@‚Ì—‰ð‚ÉÅ“_‚ð‚ ‚ÄA–Í‹[Ù”»‚ðŽæ‚è“ü‚ꂽ’†ŠwZŽÐ‰ï‰È‚ÌŽö‹ÆŠJ”­‚ðs‚È‚¨‚¤‚Æ‚·‚é‚à‚Ì‚Å‚ ‚éB“ú–{‚̎Љï‰È‚É‚¨‚¯‚é–@‹³ˆç‚ÍA]—ˆ‚©‚猛–@ŠwK‚ª’†S‚Æ‚È‚Á‚Ä‚¨‚èA‚»‚Ì‘¼‚Ì–@—¥‚ɂ‚¢‚ÄŠw‚Ô‹@‰ï‚Í”ñí‚É­‚È‚¢B‚»‚̂悤‚ÈŒ»ó‚𓥂܂¦‚ÄA‹ß”NA–¯–@‚âŒY–@‚È‚Ç‚ðŽæ‚èã‚°‚½–@‹³ˆç‚ÌŽö‹ÆŠJ”­‚ªs‚í‚ê‚é‚悤‚É‚È‚Á‚½B‚»‚̈ê•û‚ÅAÙ”»ˆõ§“x“±“üˆÈ~A–Í‹[Ù”»‚ðŽæ‚è“ü‚ꂽŽÐ‰ï‰ÈŽö‹Æ‚ÌŠJ”­EŽÀ‘H‚ª‚æ‚­Œ©‚ç‚ê‚é‚悤‚É‚È‚Á‚Ä‚¨‚èAŒYŽ–Ž–Œ‚ªŽÐ‰ï‰ÈŽö‹Æ‚ÅŽæ‚èã‚°‚ç‚ê‚邱‚Æ‚à’¿‚µ‚­‚Í‚È‚­‚È‚Á‚½B‚µ‚©‚µA‚»‚̂悤‚ÈŽö‹Æ‚ð’S“–‚·‚鋳ˆõ‚ÉAŒY–@“™‚ÉŠÖ‚·‚é’mŽ¯‚ª\•ª‚Å‚Í‚È‚­A–Í‹[Ù”»‚Ì“à—e‚ÆŽÀÛ‚ÌÙ”»‚ª˜¨—£‚µ‚Ä‚¢‚é‚Æ‚¢‚¤‰Û‘è‚à‚ ‚éB–{Œ¤‹†‚Å‚ÍA]—ˆ‚Ì–Í‹[Ù”»‚ðŽæ‚è“ü‚ꂽŽö‹Æ‚Ì“ÁŽ¿‚Ɖۑè‚ðŒŸ“¢‚µ‚½‚¤‚¦‚ÅAŒY–@‚̈Ӌ`‚𑨂¦‚³‚¹‚é’†ŠwZŽÐ‰ï‰È‚ÌŽö‹ÆŠJ”­‚ð–ÚŽw‚·B en-copyright= kn-copyright= en-aut-name=MIYAMOTOAyuha en-aut-sei=MIYAMOTO en-aut-mei=Ayuha kn-aut-name=‹{–{‚ ‚ä‚Í kn-aut-sei=‹{–{ kn-aut-mei=‚ ‚ä‚Í aut-affil-num=1 ORCID= en-aut-name=KUWABARAToshinori en-aut-sei=KUWABARA en-aut-mei=Toshinori kn-aut-name=ŒKŒ´•q“T kn-aut-sei=ŒKŒ´ kn-aut-mei=•q“T aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Human ities and So cial Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»ŠwŒ¤‹†‰ÈŽÐ‰ï•¶‰»ŠwêU affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=Žö‹ÆŠJ”­Œ¤‹† (Lesson development research) kn-keyword=Žö‹ÆŠJ”­Œ¤‹† (Lesson development research) en-keyword=’†ŠwZŽÐ‰ï‰È (Junior high school social studies) kn-keyword=’†ŠwZŽÐ‰ï‰È (Junior high school social studies) en-keyword=–Í‹[Ù”» (Mock trial) kn-keyword=–Í‹[Ù”» (Mock trial) en-keyword=ŒY–@ (Criminal law) kn-keyword=ŒY–@ (Criminal law) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=139 end-page=152 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical Issues on Differences in Hours of Attendance as Seen in an Interview of Initial Appointment Child Care Teachers kn-title=‰”C•Ûˆç‹³—@‚ÌŒê‚è‚ÉŒ©‚鉀Ž™‚Ì݉€ŽžŠÔ‚̈Ⴂ‚É‚æ‚éŽÀ‘Hã‚̉ۑè en-subtitle= kn-subtitle= en-abstract=In this paper, we examined practical issues and responses through interviews with novice childcare teachers with a focus on the differences in the length of kindergarteners' attendance time, which characterizes certified childcare centers. As a result, it became obvious that childcare teachers were aware of eight challenges. In addition to the challenge with respect to the gdevelopment of childcare ensuring the continuity of playh described in the gGuidelines for Education and Childcare for Certified Childcare Centers,h furthermore, a new challenge regarding gunderstanding of kindergarteners in consideration of their various attendance time and lifestylesh not described in it was identified. Differences in attendance time due to certification classification inevitably lead to differences in time schedules, locations, and groups during certified childcare centers life. Therefore, in order to clarify what common experiences should be established in certified childcare centers life, what differences in experience should be utilized, and what kind of childcare should be practiced based on the goals set by childcare teachers, a future challenge is to collect and organize good practice examples that have been accumulated so far in certified nurseries and to clarify indicators. kn-abstract=@–{˜_‚Å‚ÍC—c•Û˜AŒgŒ^”F’肱‚Ç‚à‰€‚Ì“Á’¥‚Å‚ ‚鉀Ž™‚Ì݉€ŽžŠÔ‚̈Ⴂ‚ÉÅ“_‚ð“–‚ÄC‰”C•Ûˆç‹³—@‚Ö‚Ì–ÊÚ’²¸‚É‚æ‚èŽÀ‘Hã‚̉ۑè‚ƑΉž‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½B‚»‚ÌŒ‹‰ÊC•Ûˆç‹³—@‚ª‚W‚‚̉ۑè‚ð”FŽ¯‚µ‚Ä‚¢‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½B‚Ü‚½Cw—c•Û˜AŒgŒ^”F’肱‚Ç‚à‰€‹³ˆçE•Ûˆç—v—Ìx‚É‹Lq‚³‚ê‚Ä‚¢‚éu—V‚т̘A‘±«‚ð•Ûá‚·‚é•Ûˆç‚Ì“WŠJv‚ÉŠÖ‚·‚é‰Û‘è‚ɉÁ‚¦‚ÄC‹Lq‚³‚ê‚Ä‚¢‚È‚¢u‘½—l‚È݉€ŽžŠÔ‚ⶊˆŒ`‘Ô‚ðl—¶‚µ‚½‰€Ž™—‰ðv‚ÉŠÖ‚·‚éV‚½‚ȉۑ肪Œ©o‚³‚ꂽB”F’è‹æ•ª‚É‚æ‚é݉€ŽžŠÔ‚̈Ⴂ‚͉€¶Šˆ‚É‚¨‚¯‚鎞ŠÔ“IƒXƒPƒWƒ…[ƒ‹‚âêŠCW’c‚̈Ⴂ‚ð—]‹V‚È‚­‚³‚ê‚éB‚»‚Ì‚½‚ßC•Ûˆç‹³—@‚ªÝ’è‚·‚é‚Ë‚ç‚¢‚ÉŠî‚¢‚½‰€¶Šˆ‚ʼn½‚ð‹¤’ÊŒoŒ±‚Æ‚·‚ׂ«“à—e‚Æ‚µ‚Äݒ肵C‰½‚ðŒoŒ±·‚Æ‚µ‚ÄŠˆ‚©‚µC‚ǂ̂悤‚È•Ûˆç‚ðŽÀ‘H‚·‚é‚©–¾Šm‚É‚·‚ׂ­C‚±‚ê‚Ü‚Å”F’肱‚Ç‚à‰€‚ÅÏ‚Ýd‚Ë‚ç‚ê‚Ä‚«‚½DŽÀ‘H—á‚ðWÏE®—‚µCŽw•W‚𖾎¦‚·‚邱‚Æ‚ª¡Œã‚̉ۑè‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=HASUIKazuya en-aut-sei=HASUI en-aut-mei=Kazuya kn-aut-name=˜@ˆä˜a–ç kn-aut-sei=˜@ˆä kn-aut-mei=˜a–ç aut-affil-num=1 ORCID= en-aut-name=KATAYAMAMika en-aut-sei=KATAYAMA en-aut-mei=Mika kn-aut-name=•ÐŽR”ü kn-aut-sei=•ÐŽR kn-aut-mei=”ü aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Health and WelfareC Kawasaki University of Medical Welfare kn-affil=ìèˆã—ÕŸŽƒ‘åŠwˆã—ÕŸŽƒŠw•” affil-num=2 en-affil=Faculty of Education, Graduate School of Science, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=”F’肱‚Ç‚à‰€ (Certified Children Centers) kn-keyword=”F’肱‚Ç‚à‰€ (Certified Children Centers) en-keyword=݉€ŽžŠÔ‚̈Ⴂ (Differences in Hours of Attendance) kn-keyword=݉€ŽžŠÔ‚̈Ⴂ (Differences in Hours of Attendance) en-keyword=ŽÀ‘Hã‚̉ۑè (Issues in Childcare) kn-keyword=ŽÀ‘Hã‚̉ۑè (Issues in Childcare) en-keyword=‰”C•Ûˆç‹³—@ (Initial Appointment Child Care Teachers) kn-keyword=‰”C•Ûˆç‹³—@ (Initial Appointment Child Care Teachers) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=123 end-page=137 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on the Involvement of Community Wind Bands in the Community Development of Wind Band Activities; Can Community Wind Bands Serve as Key Supporters in Community Development of Club Activities? kn-title=‘tŠyŠˆ“®‚Ì’nˆæ“WŠJ‚É‚¨‚¯‚éŽs–¯‘tŠy’c‚ÌŠÖ‚í‚è‚ÉŠÖ‚·‚錤‹† \Žs–¯‘tŠy’c‚Í’nˆæ“WŠJ‚Ì’S‚¢Žè‚ɂȂ蓾‚é‚©\ en-subtitle= kn-subtitle= en-abstract=In the community development of wind band activities, the shortage of instructors and rehearsal spaces has become an urgent issue. This study investigates whether community wind bands can serve as key supporters of community development of childrenf s wind band activities progresses. Based on interviews with 20 community wind bands in Okayama Prefecture and text mining analysis, the study revealed differences in their awareness toward community development of club activities. More proactive bands tended to view providing musical instruction to children and engaging in joint activities positively. On the other hand, concerns about instructional skills, time constraints, and the burden of responsibility were identified as potential obstacles. Furthermore, the findings suggest that utilizing public school facilities could help address the issues of rehearsal space and financial constraints faced by community wind bands. However, disparities among municipalities were also found in the actual implementation of public school facility use systems. kn-abstract=@‘tŠyŠˆ“®‚Ì’nˆæ“WŠJiˆÈ‰ºA’nˆæ“WŠJj‚É‚¨‚¢‚ÄAŽw“±ŽÒ‚⊈“®êŠ‚Ì•s‘«‚Í‹i‹Ù‚̉ۑè‚Å‚ ‚éB–{Œ¤‹†‚ÍA’nˆæ“WŠJ‚ªi‚Þ’†‚ÅAŽs–¯‘tŠy’c‚ª’nˆæ‚ÌŽq‚Ç‚à’B‚Ì‘tŠyŠˆ“®‚ðŽx‚¦‚é’S‚¢Žè‚ƂȂ蓾‚é‚©‚𒲸EŒŸ“¢‚µ‚½B‰ªŽRŒ§“à‚ÌŽs–¯‘tŠy’c20 ’c‘Ì‚Ö‚Ì•·‚«Žæ‚è’²¸‚ƃeƒLƒXƒgƒ}ƒCƒjƒ“ƒO•ªÍ‚ÌŒ‹‰ÊA’nˆæ“WŠJ‚ւ̈ӎ¯‚É‚Í·‚ª‚Ý‚ç‚êAÏ‹É“I‚È’c‘Ì‚Å‚ÍŽq‚Ç‚à’B‚̉‰‘tŽw“±‚⇓¯‚Å‚ÌŠˆ“®‚ðm’è“I‚É‘¨‚¦‚éŒXŒü‚ªŠm”F‚³‚ꂽBˆê•û‚ÅAŽw“±‹Zp‚⎞ŠÔ“I§–ñAÓ”C•‰’S‚Ö‚Ì•sˆÀ‚ªá•Ç‚Æ‚È‚Á‚Ä‚¢‚é‰Â”\«‚ªŽ¦´‚³‚ꂽB‚Ü‚½AŽs–¯‘tŠy’c‚ª•ø‚¦‚銈“®êŠ‚âà­“I‚ȉۑè‚ɑ΂µ‚ÄŒö—§ŠwZŽ{Ý‚ÌŠˆ—p‚ª‚»‚Ì‰ðŒˆ‚ÉŠñ—^‚µ“¾‚é‰Â”\«‚ªŽ¦´‚³‚ꂽBˆê•û‚ÅAŒö—§ŠwZ‚ÌŽ{ÝŠJ•ú‚ɂ‚¢‚Ä‚ÍAŽÀۂ̧“x‰^—p‚É‚¨‚¢‚ÄŽ©Ž¡‘ÌŠÔ‚ÌŠi·‚ª‘¶Ý‚·‚邱‚Æ‚ª–¾‚ç‚©‚Æ‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=MAKINOKunihiko en-aut-sei=MAKINO en-aut-mei=Kunihiko kn-aut-name=ê –ì–M•F kn-aut-sei=ê –ì kn-aut-mei=–M•F aut-affil-num=1 ORCID= affil-num=1 en-affil=Center for Teacher Education and DevelopmentAOkayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ ‹³ˆç„i‹@\‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[ en-keyword=’nˆæ“WŠJ (community development of club activities) kn-keyword=’nˆæ“WŠJ (community development of club activities) en-keyword=Žs–¯‘tŠy’c (community wind band) kn-keyword=Žs–¯‘tŠy’c (community wind band) en-keyword=’nˆæƒNƒ‰ƒuŠˆ“® (regional club activities) kn-keyword=’nˆæƒNƒ‰ƒuŠˆ“® (regional club activities) en-keyword=ŠwZŽ{ÝŠJ•ú (community use of school facilities) kn-keyword=ŠwZŽ{ÝŠJ•ú (community use of school facilities) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=107 end-page=121 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Developing Lesson Plan for Global Citizenship Education in Junior High School Music Education through Japan-Korea Music Cultural Exchange: Based on Research Findings from an Internship at APCEIU kn-title=“úŠØ‚̉¹Šy•¶‰»Œð—¬‚ð’Ê‚µ‚½’†ŠwZ‰¹Šy‰È‚É‚¨‚¯‚éƒOƒ[ƒoƒ‹EƒVƒeƒBƒYƒ“ƒVƒbƒv‹³ˆç‚Ì\‘z \APCEIU‚ł̃Cƒ“ƒ^[ƒ“ƒVƒbƒv‚É‚¨‚¯‚é’²¸‚̬‰Ê‚ÉŠî‚¢‚Ä\ en-subtitle= kn-subtitle= en-abstract=This paper proposes a Global Citizenship Education program for junior high school music classes. The program aims to promote mutual understanding by having students examine the musical cultures of Japan and Korea, identifying their cultural differences and commonalities. In designing the program, author Konishi drew upon methods of GCED being implemented in Korea, identified through field research conducted during a roughly one-month internship at APCEIU (Asia-Pacific Centre of Education for International Understanding) in Seoul, Korea. The developed program focused on percussion instruments from both Japan and Korea. By comparing these instruments, students identified cultural differences between the two countries. The program then aimed to deepen students' understanding of cultural diversity and the unique value of each country's culture, while also helping them recognize the historical background underlying each nation's musical culture and accept these differences. kn-abstract=@–{˜_•¶‚ÍA’†ŠwZ‰¹Šy‰È‚É‚¨‚¢‚ÄA“ú–{‚ÆŠØ‘‚̉¹Šy•¶‰»‚ðŽæ‚èã‚°‚ÄAŒÝ‚¢‚Ì•¶‰»‚̈Ⴂ‚⋤’Ê«‚𑨂¦‚³‚¹‚½‚¤‚¦‚Å‘ŠŒÝ—‰ð‚ð‘£i‚·‚éAƒOƒ‹[ƒoƒ‹EƒVƒeƒBƒYƒ“ƒVƒbƒv‹³ˆçiˆÈ‰ºAGCED ‚Æ•\‹LjƒvƒƒOƒ‰ƒ€‚ð\‘z‚µ‚悤‚Æ‚·‚é‚à‚Ì‚Å‚ ‚éBƒvƒƒOƒ‰ƒ€‚Ì\‘z‚ÌÛ‚É‚ÍA•MŽÒ‚Å‚ ‚鬼‚ªAŠØ‘‚̃\ƒEƒ‹‚ÌAPCEIUiƒAƒWƒA‘¾•½—m‘Û—‰ð‹³ˆçƒZƒ“ƒ^[j‚Ås‚È‚Á‚½–ñˆê‚©ŒŽŠÔ‚̃Cƒ“ƒ^[ƒ“ƒVƒbƒv‚ÌŠÔ‚ÌŽÀ’n’²¸‚Å”cˆ¬‚µ‚½AŠØ‘‚Å“WŠJ‚³‚ê‚Ä‚¢‚éGCED ‚Ì•û–@‚ðŽQl‚É‚µ‚½BŠJ”­ƒvƒƒOƒ‰ƒ€‚Å‚ÍA“úŠØ—¼‘‚Ì‘ÅŠyŠí‚ðŽæ‚èã‚°‚ÄA‚»‚Ì”äŠr‚©‚çŒÝ‚¢‚Ì•¶‰»‚̈Ⴂ‚𑨂¦‚³‚¹‚½‚¤‚¦‚ÅAˆá‚¢‚ðŽó‚¯“ü‚ê‚È‚ª‚çA‚»‚ꂼ‚ê‚Ì‘‚̉¹Šy•¶‰»‚̪’ê‚É‚ ‚é—ðŽj“I”wŒi‚É‹C‚©‚¹‚½‚¤‚¦‚ÅA•¶‰»‚Ì‘½—l«‚â—¼‘‚Ì•¶‰»‚̌ŗL‚̉¿’l‚ɑ΂·‚é—‰ð‚ð[‚߂邱‚Æ‚ð–ÚŽw‚µ‚½B en-copyright= kn-copyright= en-aut-name=KONISHIHikari en-aut-sei=KONISHI en-aut-mei=Hikari kn-aut-name=¬¼Œõ kn-aut-sei=¬¼ kn-aut-mei=Œõ aut-affil-num=1 ORCID= en-aut-name=KUWABARAToshinori en-aut-sei=KUWABARA en-aut-mei=Toshinori kn-aut-name=ŒKŒ´•q“T kn-aut-sei=ŒKŒ´ kn-aut-mei=•q“T aut-affil-num=2 ORCID= en-aut-name=KONISHIYumi en-aut-sei=KONISHI en-aut-mei=Yumi kn-aut-name=¬¼—T”ü kn-aut-sei=¬¼ kn-aut-mei=—T”ü aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Education kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=2 en-affil=Faculty of Education kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Graduate School of Education kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È en-keyword=ƒOƒ[ƒoƒ‹EƒVƒeƒBƒYƒ“ƒVƒbƒv‹³ˆç (Global Citizenship Education) kn-keyword=ƒOƒ[ƒoƒ‹EƒVƒeƒBƒYƒ“ƒVƒbƒv‹³ˆç (Global Citizenship Education) en-keyword=‰¹Šy‰È (Music Education) kn-keyword=‰¹Šy‰È (Music Education) en-keyword=ˆÙ•¶‰»—‰ð (Cross-Cultural Understanding) kn-keyword=ˆÙ•¶‰»—‰ð (Cross-Cultural Understanding) en-keyword=Žö‹ÆŠJ”­ (Lesson Development) kn-keyword=Žö‹ÆŠJ”­ (Lesson Development) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=91 end-page=105 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical Research on Nurturing the Next Generation of Classical Japanese Instrument Music that Connects the Local and the Global Community (3) . The Potential for Developing Intercultural Competence through Questionnaire Surveys of Elementary and Junior High School Student. kn-title=’nˆæŽÐ‰ï‚ƃOƒ[ƒoƒ‹‚ð‚‚Ȃ®˜aŠyŠí‰¹ŠyŽŸ¢‘ãˆç¬‚ÌŽÀ‘HŒ¤‹†i‚Rj ¬’†Šw¶‚ÌŽ¿–⎆’²¸‚ÉŒ©‚éuˆÙ•¶‰»ŠÔ”\—Ívˆç¬‚̉”\« en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚ÍCu‚¨‚©‚â‚Ü‘Û˜aŠyŠíŠw¶ƒtƒFƒXƒeƒBƒoƒ‹v‚ÌŽÀ‘H‚É‚¨‚¯‚éCˆÙ•¶‰»ŠÔ”\—͈笂̉”\«‚ɂ‚¢‚ÄCŽQ‰Á‚µ‚½¬’†Šw¶‚ÌŽ¿–⎆’²¸Œ‹‰Ê‚©‚猟“¢‚µ‚½B
@‚»‚ÌŒ‹‰ÊC‚Pj‘ÌŒ±‚ð’Ê‚µ‚ÄŒ`¬‚³‚ꂽV‚½‚È”FŽ¯‚É‚æ‚èC˜aŠyŠí‰¹Šy•¶‰»‚ÆŽ©ŒÈ‚Æ‚ÌŠÖŒW«‚ðÄ”FŽ¯EÄ\’z‚µC˜aŠyŠí‰¹Šy•¶‰»‚Ö‚ÌÏ‹É“I‚ÈŠÖ—^‚ðŽ¦‚·‰¿’l‚¯EˆÓ–¡‚¯‚ªs‚í‚êC“à݉»‚ª‘£‚³‚ꂽ‚±‚ÆC‚Qj‰z‹«•¶‰»‚Æ‚µ‚Ă̘aŠyŠí‰¹Šy•¶‰»‚ɑ΂µ‚ÄCŠJ•ú“IE‘¸d“I‘Ô“x‚ðŽ¦‚µ‚Ä‚¢‚½‚ªCŽ©ŒÈ‚Ì•¶‰»“IƒAƒCƒfƒ“ƒeƒBƒeƒB‚ðˆÓŽ¯‚·‚éŒ_‹@‚Æ‚È‚Á‚½‚±‚ÆC‚Rj˜aŠyŠí‰¹Šy‚Ì‹¤—L‚ð’Ê‚µ‚Ķ‚¶‚½‹¤Š´‚Ìã‚ÉC‘ŠŒÝ—‰ð‚⋦“­ŠÖŒW‚ª\’z‚³‚ê‚Ä‚¢‚½‚±‚ÆC‚Sju•¶‰»‚Ì‹¤—L‚̉”\«‚ɂ‚¢‚Ä‚Ì”FŽ¯v‚ªŒ`¬‚³‚ê‚é‚È‚ÇCƒtƒFƒXƒeƒBƒoƒ‹‚Å‚ÌŒoŒ±‚ªC•¶‰»ŠÏ‚ÌŒ`¬‚ɉe‹¿‚ð—^‚¦‚éŒ_‹@‚Æ‚È‚Á‚Ä‚¢‚½‚±‚ÆC‚ª–¾‚ç‚©‚É‚È‚Á‚½B en-copyright= kn-copyright= en-aut-name=HAYAKAWARinko en-aut-sei=HAYAKAWA en-aut-mei=Rinko kn-aut-name=‘ì—ÏŽq kn-aut-sei=‘ì kn-aut-mei=—ÏŽq aut-affil-num=1 ORCID= en-aut-name=BEPPUYuko en-aut-sei=BEPPU en-aut-mei=Yuko kn-aut-name=•Ê•{—SŽq kn-aut-sei=•Ê•{ kn-aut-mei=—SŽq aut-affil-num=2 ORCID= en-aut-name=YAMAJIMiho en-aut-sei=YAMAJI en-aut-mei=Miho kn-aut-name=ŽR˜H‚Ý‚Ù kn-aut-sei=ŽR˜H kn-aut-mei=‚Ý‚Ù aut-affil-num=3 ORCID= en-aut-name=HANAKUSAYoko en-aut-sei=HANAKUSA en-aut-mei=Yoko kn-aut-name=‰Ô‘—eŽq kn-aut-sei=‰Ô‘ kn-aut-mei=—eŽq aut-affil-num=4 ORCID= en-aut-name=TAKESHITANoriko en-aut-sei=TAKESHITA en-aut-mei=Noriko kn-aut-name=’|‰º‘¥Žq kn-aut-sei=’|‰º kn-aut-mei=‘¥Žq aut-affil-num=5 ORCID= en-aut-name=TAKASUHiromi en-aut-sei=TAKASU en-aut-mei=Hiromi kn-aut-name=ûü{—T”ü kn-aut-sei=ûü{ kn-aut-mei=—T”ü aut-affil-num=6 ORCID= en-aut-name=MIYOSHIKeiko en-aut-sei=MIYOSHI en-aut-mei=Keiko kn-aut-name=ŽODŒ[Žq kn-aut-sei=ŽOD kn-aut-mei=Œ[Žq aut-affil-num=7 ORCID= en-aut-name=SHIMIZUNaoko en-aut-sei=SHIMIZU en-aut-mei=Naoko kn-aut-name=´…®Žq kn-aut-sei=´… kn-aut-mei=®Žq aut-affil-num=8 ORCID= en-aut-name=TOSAChihiro en-aut-sei=TOSA en-aut-mei=Chihiro kn-aut-name=“y²çh kn-aut-sei=“y² kn-aut-mei=çh aut-affil-num=9 ORCID= en-aut-name=NAKAMURA Ai en-aut-sei=NAKAMURA en-aut-mei=Ai kn-aut-name=’†‘ºˆ¤ kn-aut-sei=’†‘º kn-aut-mei=ˆ¤ aut-affil-num=10 ORCID= en-aut-name=HIGUCHIAki en-aut-sei=HIGUCHI en-aut-mei=Aki kn-aut-name=”óŒûˆŸŠó kn-aut-sei=”óŒû kn-aut-mei=ˆŸŠó aut-affil-num=11 ORCID= affil-num=1 en-affil=Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Kurashiki City College kn-affil=‘q•~Žs—§’ZŠú‘åŠw affil-num=3 en-affil=Part-time Lecturer at Okayama University kn-affil=‰ªŽR‘åŠw”ñí‹ÎuŽt affil-num=4 en-affil=Research Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È affil-num=5 en-affil=Biwako-Gakuin University kn-affil=‚т킱Šw‰@‘åŠw’ZŠú‘åŠw•” affil-num=6 en-affil=Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=7 en-affil=Research Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È affil-num=8 en-affil=Doctoral Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È affil-num=9 en-affil=Yamaha Corporation kn-affil=ƒ„ƒ}ƒnŠ”Ž®‰ïŽÐŠyŠíŽ–‹Æ–{•” affil-num=10 en-affil=Doctoral Student at the Joint Graduate School in Science of School Education Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È affil-num=11 en-affil=Okayama Prefectural School for the Deaf kn-affil=‰ªŽRŒ§—§‰ªŽR˜WŠwZ en-keyword=˜aŠyŠí‰¹Šy (Classical Japanese instrument) kn-keyword=˜aŠyŠí‰¹Šy (Classical Japanese instrument) en-keyword=ˆÙ•¶‰»ŠÔ”\—Í (eIntercultural Competencef) kn-keyword=ˆÙ•¶‰»ŠÔ”\—Í (eIntercultural Competencef) en-keyword=ŽŸ¢‘ãˆç¬ (the next generation) kn-keyword=ŽŸ¢‘ãˆç¬ (the next generation) en-keyword=Ž¿–⎆’²¸ (questionnaire survey) kn-keyword=Ž¿–⎆’²¸ (questionnaire survey) en-keyword=¬Šw¶E’†Šw¶ (elementary and junior high school students) kn-keyword=¬Šw¶E’†Šw¶ (elementary and junior high school students) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=75 end-page=89 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Summer Climate around Germany and the German Lied gIm Fr?hlingh (In Spring) by F. Schubert: A Report of an Interdisciplinary Lesson Practice at the University Leading to the Understanding of Heterogeneous Others kn-title=ƒhƒCƒc•t‹ß‚̉Ă̋CŒó‚ƃVƒ…[ƒxƒ‹ƒg‚̉̋Èst‚Ét ˆÙŽ¿‚È‘¼ŽÒ‚Æ‚Ìo‰ï‚¢‚𑣂·‘åŠw‚Å‚ÌŠwÛ“IŽö‹Æ‚Ì•ñ en-subtitle= kn-subtitle= en-abstract=An interdisciplinary lesson practice for the university students leading to the understanding of heterogeneous others was made on a topic of summer climate and the seasonal feeling around Germany, as a continuing study of Kato et al. (2025). In the lesson practice, details of the climate and seasonal cycle around Germany were firstly explained and the German lied gIm Fr?hlingh (In spring) composed by F. Schubert was appreciated, paying attention to how the scenes and emotions expressed by the lyrics gall summer longh in the 3rd verse of this song might differ whether we imagine the climate around Germany or that around Japan. It seems that the present activity provided an opportunity for the students to perceive the climate environments and seasonal feelings quite different from those familiar to them . However, how to explore the appreciation activities that focus also on the musical expression itself of that song is an interesting remaining problem, in order for the students to capture the summer scenery and emotions which Schubert himself imagined. kn-abstract=@uˆÙŽ¿‚È‘¼ŽÒv‚Ö‚Ìo‰ï‚¢‚𑣂·Žö‹Æ—á‚ÌX‚È‚é’~Ï‚Ì‚½‚ßCƒhƒCƒc•t‹ß‚Ìu‰Äv‚Ì‹CŒó‚Æ‹Gߊ´‚É’–Ú‚µ‚½‹³‰È‰¡’f“I‚ÈŽö‹Æ‚ð‘åŠw‚ÅŽÀ‘H‚µ‚½BŽö‹Æ‚Å‚ÍCƒhƒCƒc•t‹ß‚Ì‹CŒó‚Æ‹G߃TƒCƒNƒ‹‚Ì’†‚Å‚Ìu‰Äv‚Ì“Á’¥‚ð”cˆ¬‚·‚é‚Æ‹¤‚ÉCƒVƒ…[ƒxƒ‹ƒg‚̉̋Èst‚Ét‚ðŠÓÜ‚µ‚½Bst‚Ét‚Ì3 ”Ô‚Ìu‰Ä‚ÌŠÔ‚¶‚イC‚¸‚Á‚Æv‚Æ‚¢‚¤‰ÌŽŒ‚ʼn̂í‚ê‚Ä‚¢‚éîŒi‚â‚ªCƒhƒCƒc•t‹ß‚Æ“ú–{•t‹ß‚ð‘z’肵‚½ê‡‚É‚Ç‚¤ˆá‚¢“¾‚é‚©C‚ÉŠÖ‚·‚éŽóu¶‚Ì‹Lq‚ð•ªÍ‚µ‚½B‚»‚ÌŒ‹‰ÊC“ú–{‚̉Ă̂‰·‘½Ž¼‚Ȋ‹«‚©‚ç‚ÍŒ´Ž‚Ì‚»‚Ì‚à‚Ì‚ª¬—§‚µ“ï‚¢‚ÆŠ´‚¶‚½Šw¶‚à‚¢‚é‚È‚ÇC–{ŽÀ‘H‚ÍCŽ©•ª‚½‚¿‚Ìu“–‚½‚è‘Ov‚Ƃ͈قȂé‹CŒó‚â‹Gߊ´‚É‚à–Ú‚ðŒü‚¯‚é‹@‰ï‚ɂȂ蓾‚½‚Æ‚¢‚¦‚éBˆê•ûC“ú–{‚Æ‚Í‚©‚È‚èˆá‚¤‹CŒó”wŒi‚Ì’†‚ŃVƒ…[ƒxƒ‹ƒg‚ªŽv‚¢•`‚¢‚½‚Å‚ ‚낤îŒiESî‚ÉŽö‹Æ‚Å[‚­”—‚邽‚ß‚ÌC‰¹Šy•\Œ»Ž©‘Ì‚Ö‚Ì“¥‚Ýž‚Ý•û‚ɂ‚¢‚Ä‚àC¡ŒãŒŸ“¢‚·‚é•K—v«‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=KATOKuranoshin en-aut-sei=KATO en-aut-mei=Kuranoshin kn-aut-name=‰Á“¡“àåUi kn-aut-sei=‰Á“¡ kn-aut-mei=“àåUi aut-affil-num=1 ORCID= en-aut-name=NAGAOKAIsao en-aut-sei=NAGAOKA en-aut-mei=Isao kn-aut-name=’·‰ªŒ÷ kn-aut-sei=’·‰ª kn-aut-mei=Œ÷ aut-affil-num=2 ORCID= en-aut-name=KATOHaruko en-aut-sei=KATO en-aut-mei=Haruko kn-aut-name=‰Á“¡°Žq kn-aut-sei=‰Á“¡ kn-aut-mei=°Žq aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=3 en-affil=Faculty of Education, Gufu Shotoku Gakuen University (Former affiliation) kn-affil=Œ³@Šò•Œ¹“¿Šw‰€‘åŠw‹³ˆçŠw•” en-keyword=‹CŒó‚Ɖ¹Šy kn-keyword=‹CŒó‚Ɖ¹Šy en-keyword=ƒhƒCƒc•t‹ß‚̉Ă̋CŒó‚Æ‹Gߊ´ kn-keyword=ƒhƒCƒc•t‹ß‚̉Ă̋CŒó‚Æ‹Gߊ´ en-keyword=‹CŒó‚Æ•¶‰»—‰ð‚ÌŠwÛ“IESD‹³Žt‹³ˆç kn-keyword=‹CŒó‚Æ•¶‰»—‰ð‚ÌŠwÛ“IESD‹³Žt‹³ˆç en-keyword=ˆÙŽ¿‚È‘¼ŽÒ‚Ö‚Ì—‰ð kn-keyword=ˆÙŽ¿‚È‘¼ŽÒ‚Ö‚Ì—‰ð END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=61 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on Physical Activity Levels During Soccer Matches Among Junior High School Students Focusing on Position and Physical/Fitness Characteristics kn-title=’†Šw¶‚ð‘ÎÛ‚Æ‚µ‚½ƒTƒbƒJ[ŽŽ‡’†‚Ìg‘ÌŠˆ“®—Ê‚ÉŠÖ‚·‚錤‹† `ƒ|ƒWƒVƒ‡ƒ“‚Æg‘ÌE‘Ì—Í“Á«‚É’…–Ú‚µ‚Ä` en-subtitle= kn-subtitle= en-abstract=We compared physical and fitness characteristics by soccer position using results from the New Physical Fitness Test administered to 30 junior high school students. Additionally, we compared differences in physical activity levels by position during soccer matches while wearing LC devices. The results showed no significant differences in physical or fitness characteristics between positions. However, significant differences were observed between positions in step count and the proportion of time spent in physical activity by intensity level. This revealed that physical activity levels during soccer matches differ between positions even among junior high school students, clarifying position-specific characteristics in soccer. It also suggested the usefulness of evaluating physical activity levels during matches over time. kn-abstract=@’†Šw¶34l‚ð‘ÎÛ‚Æ‚µCg‘ÌE‘Ì—Í“Á«‚ƃTƒbƒJ[ŽŽ‡’†‚Ìg‘ÌŠˆ“®—ʂɂ‚¢‚ÄCƒ|ƒWƒVƒ‡ƒ“‚É’…–Ú‚µ‚Ä”äŠrEŒŸ“¢‚µ‚½D‚»‚ÌŒ‹‰ÊCg‘ÌE‘Ì—Í“Á«‚ɂ‚¢‚Ă̓|ƒWƒVƒ‡ƒ“ŠÔ‚É—LˆÓ‚È·‚Í”F‚ß‚ç‚ê‚È‚©‚Á‚½D•à”‚ł̓|ƒWƒVƒ‡ƒ“ŠÔ‚Å—LˆÓ·‚ª”F‚ß‚ç‚êCƒ‰ƒCƒgƒTƒCƒhƒoƒbƒN‚ª­‚È‚­CƒZƒ“ƒ^[ƒ~ƒbƒhƒtƒBƒ‹ƒ_[‚ª‚‚©‚Á‚½D‹­“x•Êg‘ÌŠˆ“®—ÊŽžŠÔ‚ÌŠ„‡‚ł̓|ƒWƒVƒ‡ƒ“ŠÔ‚Å—LˆÓ·‚ª”F‚ß‚ç‚êCƒ‰ƒCƒgƒTƒCƒhƒoƒbƒN‚ª’á‚­CƒZƒ“ƒ^[ƒ~ƒbƒhƒtƒBƒ‹ƒ_[‚ª‚‚©‚Á‚½DˆÈã‚Ì‚±‚Æ‚©‚çC–{Œ¤‹†‚Ì‘ÎÛ’†Šw¶‚ł̓|ƒWƒVƒ‡ƒ“ŠÔ‚Åg‘ÌE‘Ì—Í“Á«‚É‚Í—LˆÓ·‚ª”F‚ß‚ç‚ê‚È‚¢‚ªCƒTƒbƒJ[ŽŽ‡’†‚Ìg‘ÌŠˆ“®—ʂł̓|ƒWƒVƒ‡ƒ“ŠÔ‚Å·‚ª¶‚¶‚邱‚Æ‚ªŽ¦´‚³‚ꂽD en-copyright= kn-copyright= en-aut-name=NATSUMEDATakaaki en-aut-sei=NATSUMEDA en-aut-mei=Takaaki kn-aut-name=ž¥“c‘¸‹M kn-aut-sei=ž¥“c kn-aut-mei=‘¸‹M aut-affil-num=1 ORCID= en-aut-name=ADACHIMinoru en-aut-sei=ADACHI en-aut-mei=Minoru kn-aut-name=‘«—§–« kn-aut-sei=‘«—§ kn-aut-mei=–« aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=2 en-affil=Okayama University Graduate School of Education kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=ƒTƒbƒJ[ (Soccer) kn-keyword=ƒTƒbƒJ[ (Soccer) en-keyword=’†Šw¶ (Junior High School Students) kn-keyword=’†Šw¶ (Junior High School Students) en-keyword=‰Á‘¬“xŒv (Accelerometer) kn-keyword=‰Á‘¬“xŒv (Accelerometer) en-keyword=V‘̗̓eƒXƒg (New Physical Fitness Test) kn-keyword=V‘̗̓eƒXƒg (New Physical Fitness Test) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=45 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Physical Activity and Physical Fitness in the School Life of Elementary School Children kn-title=¬Šw¶‚ÌŠwZ¶Šˆ‚É‚¨‚¯‚ég‘ÌŠˆ“®—Ê‚Æ‘Ì—Í‚ÉŠÖ‚·‚錤‹† en-subtitle= kn-subtitle= en-abstract=@The purpose of this study was to objectively measure physical activity levels during different school settings among sixth-grade elementary school children using an accelerometer, and to examine their relationship with physical fitness. Participants were 85 children (41 boys, 44 girls). Step counts and time spent in different activity intensities were evaluated during recess, physical education (PE) classes, and the whole school day. Results showed that children with higher fitness levels tended to have greater step counts and more moderate-to-vigorous physical activity (MVPA) during recess. Significant differences were found in morning recess for boys and in lunch recess and PE classes for girls. The proportion of MVPA was 11.3% during recess and 15.7% during PE classes, which was lower than that reported in other countries and did not meet international recommendations. This study provides fundamental data on physical activity in elementary school settings and suggests the importance of enhancing opportunities for physical activity, parti cularly during recess and PE classes. kn-abstract=@–{Œ¤‹†‚Ì–Ú“I‚ÍC¬ŠwZ6”N¶‚ÌŠwZ¶Šˆ‚É‚¨‚¯‚銈“®ê–Ê•Ê‚Ìg‘ÌŠˆ“®—Ê‚ð‰Á‘¬“xŒv‚ð—p‚¢‚Ä‹qŠÏ“I‚É‘ª’肵C‚»‚Ì‘Ì—Í‚Æ‚ÌŠÖŒW‚ðŒŸ“¢‚·‚邱‚Æ‚Å‚ ‚éD‘ÎۂͬŠwZŽ™“¶85–¼(’jŽq41–¼C—Žq44–¼)‚Æ‚µC‹x‚ÝŽžŠÔC‘̈çŽö‹ÆCŠwZ¶Šˆ‘S‘Ì‚É‚¨‚¯‚é•à”‚Æ‹­“x•ÊŠˆ“®ŽžŠÔ‚ð•]‰¿‚µ‚½D‚»‚ÌŒ‹‰ÊC’j—‚Æ‚à‚É‘Ì—ÍãˆÊŒQ‚Í‹x‚ÝŽžŠÔ‚É‚¨‚¢‚Ä•à”‚ÆMVPA‚ª‘½‚¢ŒXŒü‚ªŽ¦‚³‚êC“Á‚É’jŽq‚Í’†‹x‚ÝC—Žq‚Í’‹‹x‚Ý‚¨‚æ‚ё̈çŽö‹Æ‚Å—LˆÓ·‚ª”F‚ß‚ç‚ꂽDŠeŠˆ“®ê–Ê‚ÌMVPA ‚ªè‚߂銄‡‚Í‹x‚ÝŽžŠÔ11.3“C‘̈çŽö‹Æ15.7“‚Å‚ ‚èC”ŠO‘‚Æ”äŠr‚µ‚Ä­‚È‚­C‘Û“I„§’l‚É‚à“Í‚©‚È‚©‚Á‚½D–{Œ¤‹†‚ÍC¬ŠwZ‚É‚¨‚¯‚ég‘ÌŠˆ“®—Ê‚ÌŠî‘bƒf[ƒ^‚ð’ñŽ¦‚·‚é‚Æ‚Æ‚à‚ÉCŠwZ¶ŠˆC“Á‚É‹x‚ÝŽžŠÔ‚â‘̈çŽö‹Æ‚É‚¨‚¯‚ég‘ÌŠˆ“®‹@‰ï‚Ì[ŽÀ‚ª•K—v‚Å‚ ‚邱‚Æ‚ðŽ¦´‚µ‚½D en-copyright= kn-copyright= en-aut-name=YASUNOBEJin en-aut-sei=YASUNOBE en-aut-mei=Jin kn-aut-name=ˆÀ‰„m kn-aut-sei=ˆÀ‰„ kn-aut-mei=m aut-affil-num=1 ORCID= en-aut-name=SASAYAMAKensaku en-aut-sei=SASAYAMA en-aut-mei=Kensaku kn-aut-name=ùŽRŒ’ì kn-aut-sei=ùŽR kn-aut-mei=Œ’ì aut-affil-num=2 ORCID= en-aut-name=ADACHIMinoru en-aut-sei=ADACHI en-aut-mei=Minoru kn-aut-name=‘«—§–« kn-aut-sei=‘«—§ kn-aut-mei=–« aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=2 en-affil=Faculty of Education, Mie University kn-affil=ŽOd‘åŠw‹³ˆçŠw•” affil-num=3 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‰Á‘¬“xŒv (accelerometer) kn-keyword=‰Á‘¬“xŒv (accelerometer) en-keyword=g‘ÌŠˆ“®—Ê (physical activity) kn-keyword=g‘ÌŠˆ“®—Ê (physical activity) en-keyword=‘Ì—Í (physical fitness) kn-keyword=‘Ì—Í (physical fitness) en-keyword=¬ŠwZŽ™“¶ (elementary school children) kn-keyword=¬ŠwZŽ™“¶ (elementary school children) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=31 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of Factors Contributing to Confusion Regarding Left-Right Understanding of Convex Lens Images ?Proposals for Inquiry-Based Learning Based on Textbook Analysis and Teacher Questionnaire? kn-title=“ʃŒƒ“ƒY‚Ì‘œ‚̶‰E—‰ð‚ÉŠÖ‚·‚鬗‚Ì—vˆö•ªÍ ‹³‰È‘•ªÍ‚Æ‹³ˆõƒAƒ“ƒP[ƒg‚É‚æ‚é’T‹†“I‚ÈŠw‚Ñ‚Ö‚Ì’ñˆÄ en-subtitle= kn-subtitle= en-abstract=This study focused on the confusion students experience regarding the orientation of images during the learning of convex lens in junior high school. It examined the causes of this confusion, identifying insufficient awareness of experimental conditions such as the light source, screen, and observation location. To investigate, the study analyzed changes in the Course of Study for Lower Secondary Schools and textbooks and conducted a questionnaire survey of science teachers. The results revealed that while textbook descriptions have shifted toward specifying the observation location, teaching methods among teachers vary, causing confusion of students. To address these issues, a 3D-printed teaching material was developed that naturally fixes the observation viewpoint. Its effectiveness was examined through teacher training. This material was found to be effective in promoting students' intuitive understanding and bringing inquiry-based learning. kn-abstract=@–{Œ¤‹†‚ÍA’†ŠwZ—‰È‚̓ʃŒƒ“ƒYŠwK‚Ŷ“k‚ª‘œ‚ÌŒü‚«‚É•ø‚­¬—‚É’…–Ú‚µ‚½B‚»‚Ì—vˆö‚ðAŒõŒ¹EƒXƒNƒŠ[ƒ“EŠÏŽ@ꊂƂ¢‚Á‚½ŽÀŒ±ðŒ‚ª\•ª‚Ɉӎ¯‚³‚ê‚Ä‚±‚È‚©‚Á‚½“_‚É‚ ‚é‚ÆlŽ@‚µAŠwKŽw“±—v—Ì‚Æ‹³‰È‘‚Ì•Ï‘J•ªÍA‚¨‚æ‚ÑŒ»E‹³ˆõ‚ւ̃Aƒ“ƒP[ƒg’²¸‚ðŽÀŽ{‚µ‚½B‚»‚ÌŒ‹‰ÊA‹³‰È‘‚Ì‹Lq‚ÍŠÏŽ@ꊂðŽw’è‚·‚é•ûŒü‚֕ω»‚µ‚Ä‚¢‚é‚à‚Ì‚ÌAŒ»ê‹³ˆõ‚ÌŽw“±–@‚ɂ͂΂ç‚‚«‚ª‚ ‚èA¶“k‚̬—‚𵂭ˆêˆö‚Æ‚È‚Á‚Ä‚¢‚邱‚Ƃ𖾂炩‚É‚µ‚½B‚±‚ê‚ç‚̉ۑè‰ðŒˆ‚Ì‚½‚ßAŠÏŽ@Ž‹“_‚ðŽ©‘R‚ɌŒè‚Å‚«‚é3D ƒvƒŠƒ“ƒ^»‹³Þ‚ðŠJ”­‚µA‹³ˆõŒ¤C‚Å‚»‚Ì—LŒø«‚ðŒŸ“¢‚µ‚½B–{‹³Þ‚Ͷ“k‚Ì’¼Š´“I—‰ð‚𑣂µA’T‹†“I‚ÈŠw‚Ñ‚ðˆø‚«o‚·ã‚Å—LŒø‚Å‚ ‚邱‚Æ‚ªŽ¦´‚³‚ꂽB en-copyright= kn-copyright= en-aut-name=TANIMOTOKunihiko en-aut-sei=TANIMOTO en-aut-mei=Kunihiko kn-aut-name=’J–{ŒO•F kn-aut-sei=’J–{ kn-aut-mei=ŒO•F aut-affil-num=1 ORCID= en-aut-name=INADAYoshihiko en-aut-sei=INADA en-aut-mei=Yoshihiko kn-aut-name=ˆî“c‰À•F kn-aut-sei=ˆî“c kn-aut-mei=‰À•F aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=“ʃŒƒ“ƒY (Convex lens) kn-keyword=“ʃŒƒ“ƒY (Convex lens) en-keyword=㉺¶‰E‹t (the orientation of images) kn-keyword=㉺¶‰E‹t (the orientation of images) en-keyword=‹³‰È‘ (Textbooks) kn-keyword=‹³‰È‘ (Textbooks) en-keyword=ŠwKŽw“±—v—Ì (Course of Study) kn-keyword=ŠwKŽw“±—v—Ì (Course of Study) en-keyword=‚RD ƒvƒŠƒ“ƒ^ (3D printer) kn-keyword=‚RD ƒvƒŠƒ“ƒ^ (3D printer) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=15 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Critical Reading Instruction of Expository Text that Promotes Reflecting: Practice for First-year Student at High School kn-title=à–¾“I•¶Í‚ÌŽw“±‚É‚¨‚¯‚éu“àÈv‚𑣂·”á”»“I“Ç‚Ý \‚“™ŠwZ‚P”N¶‚ð‘ÎÛ‚Æ‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract=@Critical reading is an essential skill at present time and is included in government guidelines for teaching. Although recent research on teaching critical reading has been conducted, there have been criticisms that lack of consideration of content value and understanding context within society. There are also calls for critical reading that focuses on the perspective of greflecth . Therefore, this paper developed a lesson that encourages students not only critically read the text, but also critically consider (reflect on) their own ideas. As a measure to achieve this, incorporated activities such as comparing two teaching materials that contained multiple social perceptions, exchanging opinions from opposing perspectives, writing an evaluation of the materials, and having the students themselves evaluate their own writing (their own reading). Analysis of the studentsf writings shows that, while some students didnf t reach conscious reflection, about 60% of studentsf writings showed changes. And then it suggests that the methods used were effective. kn-abstract=@”á”»“I“Ç‚Ý‚ÍCŒ»‘ã‚Å‚ÍŒ‡‚©‚¹‚È‚¢”\—Í‚Å‚ ‚èCŠwKŽw“±—v—Ì‚É‚à–¾‹L‚³‚ê‚Ä‚¢‚éB‹ß”NC”á”»“I“Ç‚Ý‚ÌŽw“±‚ÉŠÖ‚·‚錤‹†‚ª‚È‚³‚ê‚Ä‚¢‚é‚à‚Ì‚ÌC“à—e“I‚ȉ¿’l‚ÌŒŸ“¢‚âŽÐ‰ï“I‚È•¶–¬‚Ì‚È‚©‚Å‘¨‚¦‚邱‚Æ‚ªŠó”–‚¾‚Æ‚·‚éŽw“E‚âCu”½È«v‚Æ‚¢‚¤ŠÏ“_‚É’…–Ú‚µ‚½”á”»“I“Ç‚Ý‚ð‹‚ß‚éº‚à‚ ‚éB‚»‚±‚ÅC–{e‚Å‚ÍC•¶Í‚»‚Ì‚à‚Ì‚ð”á”»“I‚É“Ç‚Þ‚¾‚¯‚Å‚È‚­CŽ©g‚ÌŽ‚Á‚Ä‚¢‚él‚¦‚ð‚à”á”»“I‚É‘¨‚¦‚éi“àÈ‚·‚éj‚±‚Ƃ𑣂·Žö‹Æ‚ðŠJ”­‚µ‚½B‚»‚ÌŽè—§‚Ä‚Æ‚µ‚ÄC•¡”‚̎Љï”FŽ¯‚ª‘¶Ý‚·‚é“ñ‚‚̋³Þ‚Ì“Ç‚Ý”ä‚ׂ½‚¤‚¦‚ÅC‘Η§‚·‚闧ꂩ‚ç‚̈ӌ©ŒðŠ·‚ðs‚¤‚±‚Æ‚âC‹³Þ‚ɑ΂·‚é•]‰¿‚Ì‹LqC‚»‚Ì‹LqiŽ©ŒÈ‚Ì“Ç‚Ýj‚ðŠwKŽÒŽ©g‚ª•]‰¿‚·‚é‚Æ‚¢‚Á‚½Šˆ“®‚ðŽæ‚è“ü‚ꂽBŠwKŽÒ‚Ì‹Lq‚Ì•ªÍ‚©‚ç‚ÍCˆÓŽ¯“I‚È“àÈ‚ÉŽŠ‚ç‚È‚©‚Á‚½ŠwKŽÒ‚àŒ©Žó‚¯‚ç‚ꂽ‚à‚Ì‚ÌC–ñ‚UŠ„‚ÌŠwKŽÒ‚Ì‹Lq‚É‚Í•Ï—e‚ªŒ©‚ç‚êC—p‚¢‚½Žè—§‚Ä‚ÍŒø‰Ê‚ª‚ ‚Á‚½‚Æ„‘ª‚Å‚«‚邱‚Æ‚ðŽw“E‚µ‚½B en-copyright= kn-copyright= en-aut-name=SAISHOYumi en-aut-sei=SAISHO en-aut-mei=Yumi kn-aut-name=Å‘Š—L–¢ kn-aut-sei=Å‘Š kn-aut-mei=—L–¢ aut-affil-num=1 ORCID= en-aut-name=IKEDAMasafumi en-aut-sei=IKEDA en-aut-mei=Masafumi kn-aut-name=’r“c‹§Žj kn-aut-sei=’r“c kn-aut-mei=‹§Žj aut-affil-num=2 ORCID= affil-num=1 en-affil=Graduate School of Education (Professional Degree Corse), Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=2 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=”½È« (reflectiveness) kn-keyword=”½È« (reflectiveness) en-keyword=îˆÓ“I«Œü (affective disposition) kn-keyword=îˆÓ“I«Œü (affective disposition) en-keyword=•¡”ƒeƒNƒXƒg (multiple texts) kn-keyword=•¡”ƒeƒNƒXƒg (multiple texts) en-keyword=uŒ»‘ã‚Ì‘Œêv (gContemporary Japanese Languageh) kn-keyword=uŒ»‘ã‚Ì‘Œêv (gContemporary Japanese Languageh) en-keyword=¶•¨‘½—l« (biodiversity) kn-keyword=¶•¨‘½—l« (biodiversity) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page=1 end-page=13 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Preschool Teachersf Strategies and Practical Challenges in Supporting the School Enrollment of Foreign Children kn-title=ŠO‘l—cŽ™‚ÌAŠwŽx‰‡‚É‚¨‚¯‚é•ÛˆçŽm‚ÌH•v‚ÆŽÀ‘H“I‰Û‘è en-subtitle= kn-subtitle= en-abstract=This study aimed to clarify the specific practices and challenges faced by preschool teachers in supporting foreign children at the time of school enrollment. Semi-structured interviews were conducted with two preschool teachers who had experience in supporting foreign children, and qualitative analysis using SCAT was applied to organize the support provided to both children and their parents. The results revealed that, in terms of language support, teachers utilized visual aids and simplified Japanese, while in cultural support they sought to balance family culture with the culture of the preschool. Regarding developmental support, the importance of fostering non-cognitive skills and collaborating with medical institutions was highlighted. In parent support, participatory involvement and careful explanations were practiced; however, challenges remained in providing institutional information and establishing collaboration with local governments. Based on these findings, it is necessary to establish a regional collaborative system that can provide institutional support for families with multicultural backgrounds, standardize the provision of information, and build practical mechanisms to connect with Japanese language education resources, so that support does not rely solely on the individual efforts of preschool teachers. kn-abstract=@–{Œ¤‹†‚ÍCŠO‘l—cŽ™‚ªAŠwŠú‚É’¼–Ê‚·‚颓ï‚ɑΉž‚·‚邽‚ßC•ÛˆçŽm‚ªs‚Á‚Ä‚¢‚é‹ï‘Ì“I‚È•ÛˆçŽÀ‘H‚É‚¨‚¯‚éŽx‰‡‚ÌH•v‚Ɖۑè‚𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚½BŠO‘l—cŽ™‚ÌŽx‰‡ŒoŒ±‚ð—L‚·‚é•ÛˆçŽm2 –¼‚É”¼\‘¢‰»ƒCƒ“ƒ^ƒrƒ…[‚ðs‚¢CSCAT ‚ð—p‚¢‚½Ž¿“I•ªÍ‚É‚æ‚èC—cŽ™‚¨‚æ‚Ñ•ÛŒìŽÒ‚Ö‚ÌŽx‰‡“à—e‚ð®—‚µ‚½B‚»‚ÌŒ‹‰ÊCŒ¾Œê–Ê‚Å‚ÍŽ‹Šo“IŽx‰‡‚â‚₳‚µ‚¢“ú–{Œê‚ðŠˆ—p‚µC•¶‰»–ʂł͉ƒ땶‰»‚Æ“ú–{‚̉€•¶‰»‚Ì’²®‚ªs‚í‚ê‚Ä‚¢‚½B”­’BŽx‰‡‚É‚¨‚¢‚Ä‚ÍC”ñ”F’m“IƒXƒLƒ‹‚̈笂âˆã—Ë@ŠÖ‚Ƃ̘AŒg‚Ì•K—v«‚ªŽw“E‚³‚ꂽB•ÛŒìŽÒŽx‰‡‚Å‚ÍCŽQ‰ÁŒ^‚ÌŠÖ‚í‚è‚â’š”J‚Èà–¾‚ªŽÀ‘H‚³‚ê‚Ä‚¢‚½‚ªC§“xî•ñ‚Ì’ñ‹Ÿ‚âs­‚Ƃ̘AŒg‚ɂ͉ۑ肪Žc‚³‚ꂽB‚±‚ê‚ç‚ÌŒ‹‰Ê‚𓥂܂¦C¡Œã‚Í•ÛˆçŽm‚̌•ʓI“w—͂Ɉˑ¶‚µ‚È‚¢‚½‚ß‚É‚àC‘½•¶‰»”wŒi‚ð‚à‚‰ƒë‚Ö‚ÌŽx‰‡‚ð§“x“I‚ÉŽx‚¦‚é’nˆæ˜AŒg‘̧‚Ì®”õ‚âCî•ñ’ñ‹Ÿ‚Ì•W€‰»C“ú–{Œê‹³ˆçŽ‘Œ¹‚Æ‚ÌÚ‘±‚ð}‚éŽÀ‘H“IŽd‘g‚Ý‚Ì\’z‚ª‹‚ß‚ç‚ê‚éB en-copyright= kn-copyright= en-aut-name=CHENYiwen en-aut-sei=CHEN en-aut-mei=Yiwen kn-aut-name=’ˆ˕¶ kn-aut-sei=’ kn-aut-mei=ˆË•¶ aut-affil-num=1 ORCID= en-aut-name=YANAGISAWAKazuki en-aut-sei=YANAGISAWA en-aut-mei=Kazuki kn-aut-name=–öàV‰ÀŒŽ kn-aut-sei=–öàV kn-aut-mei=‰ÀŒŽ aut-affil-num=2 ORCID= en-aut-name=REN Xinyu en-aut-sei=REN en-aut-mei= Xinyu kn-aut-name=”Cc˜° kn-aut-sei=”C kn-aut-mei=c˜° aut-affil-num=3 ORCID= en-aut-name=YOSHITOSHIMunehisa en-aut-sei=YOSHITOSHI en-aut-mei=Munehisa kn-aut-name=‹g—˜@‹v kn-aut-sei=‹g—˜ kn-aut-mei=@‹v aut-affil-num=4 ORCID= affil-num=1 en-affil=The Joint Graduate School (Ph.D. Program) in Science of School Education, Hyogo University of Teacher, Hyogo University of Teacher Education kn-affil=•ºŒÉ‹³ˆç‘åŠw‘åŠw‰@˜A‡ŠwZ‹³ˆçŠwŒ¤‹†‰È”ŽŽm‰Û’ö affil-num=2 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=3 en-affil=Graduate School of Education, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=4 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=ŠO‘l—cŽ™ (foreign preschool children) kn-keyword=ŠO‘l—cŽ™ (foreign preschool children) en-keyword=AŠw (school enrollment) kn-keyword=AŠw (school enrollment) en-keyword=•ÛˆçŽm (preschool teachers) kn-keyword=•ÛˆçŽm (preschool teachers) END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw‹³ˆç„i‹@\ ‹³Žt‹³ˆçŠJ”­ƒZƒ“ƒ^[‹I—v ‘æ16† ‘S•¶iˆêŠ‡ƒ_ƒEƒ“ƒ[ƒh—pj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinicopathological and transcriptomic profiles of 101 patients with diffuse large B-cell lymphoma/high-grade B-cell lymphoma with double-hit MYC and BCL2 or BCL6 and triple hit en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aims: Diffuse large B-cell lymphoma/high-grade B-cell lymphoma (DLBCL/HGBCL) with MYC and BCL2 rearrangements (double-hit lymphoma with BCL2, DHL-BCL2) is a mature aggressive B-cell lymphoma that also includes concurrent triple hit with BCL6 translocation (TH). DHL with MYC and BCL6 (DH-BCL6) can also occur. The differences among these three DLBCL/HGBCL subtypes have not yet been definitively determined.
Methods and Results: This study characterized the clinicopathological features and transcriptomic profiles of a series of 101 cases of DLBCL/HGBCL that were subclassified according to MYC, BCL2 and BCL6 FISH data, including cell-of-origin (COO)-like, molecular high-grade (MHG)-like and double-hit/dark-zone (DHIT/DZsig)-like signatures. DLBCL/HGBCL-DH-BCL2 was characterized by higher HGBCL morphology, CD10 positivity, GCB Hans's, GCB COO and MHG molecular subtype. DLBCL/HGBCL-TH had higher LDH levels and worse overall survival. DLBCL/HGBCL-DH-BCL6 had higher MUM1 expression, non-GCB Hans', ABC/Unclassified COO, non-MHG and low DHIT/DZ signatures. Transcriptomic analysis showed that DLBCL/HGBCL-DH-BCL2 and DLBCL/HGBCL-TH were close but separated from DLBCL/HGBCL-DH-BCL6. Gene set enrichment analysis (GSEA) revealed different levels of enrichment between the subtypes.
Conclusions: DLBCL/HGBCL-DH-BCL6 differs from the DLBCL/HGBCL-DH-BCL2, and the DLBCL/HGBCL-TH is associated with the worst survival. Analysis of all three genes of MYC, BCL2 and BCL6 is recommended in the context of DLBCL/HGBCL diagnosis. en-copyright= kn-copyright= en-aut-name=MiyaokaMasashi en-aut-sei=Miyaoka en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=CarrerasJoaquim en-aut-sei=Carreras en-aut-mei=Joaquim kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KikutiYara Yukie en-aut-sei=Kikuti en-aut-mei=Yara Yukie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IkomaHaruka en-aut-sei=Ikoma en-aut-mei=Haruka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NagaseShunsuke en-aut-sei=Nagase en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ItoAtsushi en-aut-sei=Ito en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OritaMakoto en-aut-sei=Orita en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawadaHiroshi en-aut-sei=Kawada en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SakaiRika en-aut-sei=Sakai en-aut-mei=Rika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SatoYasuharu en-aut-sei=Sato en-aut-mei=Yasuharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=NishimuraMidori Filiz en-aut-sei=Nishimura en-aut-mei=Midori Filiz kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=TsukasakiKunihiro en-aut-sei=Tsukasaki en-aut-mei=Kunihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MomoseShuji en-aut-sei=Momose en-aut-mei=Shuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KameokaYoshihiro en-aut-sei=Kameoka en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=YoshidaMasahiro en-aut-sei=Yoshida en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=SatouAkira en-aut-sei=Satou en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=KatoSeiichi en-aut-sei=Kato en-aut-mei=Seiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=OishiNaoki en-aut-sei=Oishi en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=SaitoAkio en-aut-sei=Saito en-aut-mei=Akio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=SadahiraKen en-aut-sei=Sadahira en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=MasugiYohei en-aut-sei=Masugi en-aut-mei=Yohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=NakamuraNaoya en-aut-sei=Nakamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= affil-num=1 en-affil=Department of Pathology, School of Medicine, Tokai University kn-affil= affil-num=2 en-affil=Department of Pathology, School of Medicine, Tokai University kn-affil= affil-num=3 en-affil=Department of Pathology, School of Medicine, Tokai University kn-affil= affil-num=4 en-affil=Department of Pathology, School of Medicine, Tokai University kn-affil= affil-num=5 en-affil=Department of Pathology, School of Medicine, Tokai University kn-affil= affil-num=6 en-affil=Department of Pathology, School of Medicine Tokai University Isehara Japan kn-affil= affil-num=7 en-affil=Department of Pathology, School of Medicine, Tokai University kn-affil= affil-num=8 en-affil=Department of Hematology, School of Medicine, Tokai University kn-affil= affil-num=9 en-affil=Department of Medical Oncology, Kanagawa Cancer Center kn-affil= affil-num=10 en-affil=Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences kn-affil= affil-num=11 en-affil=Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences kn-affil= affil-num=12 en-affil=Department of Hematology, International Medical Center, Saitama Medical University kn-affil= affil-num=13 en-affil=Department of Pathology, Saitama Medical Center, Saitama Medical University kn-affil= affil-num=14 en-affil=Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine kn-affil= affil-num=15 en-affil=Department of Hematology, Osaka City General Hospital kn-affil= affil-num=16 en-affil=Department of Surgical Pathology, Aichi Medical University Hospital kn-affil= affil-num=17 en-affil=Center for Clinical Pathology, Fujita Health University Hospital kn-affil= affil-num=18 en-affil=Department of Pathology, University of Yamanashi kn-affil= affil-num=19 en-affil=Department of Hematology, NHO Shibukawa Medical Center kn-affil= affil-num=20 en-affil=Division of Hematology, Kawasaki Municipal Kawasaki Hospital kn-affil= affil-num=21 en-affil=Department of Pathology, School of Medicine, Tokai University kn-affil= affil-num=22 en-affil=Department of Pathology, School of Medicine, Tokai University kn-affil= en-keyword=BCL2 kn-keyword=BCL2 en-keyword=BCL6 kn-keyword=BCL6 en-keyword=high-grade B-cell lymphoma kn-keyword=high-grade B-cell lymphoma en-keyword=molecular profile kn-keyword=molecular profile en-keyword=MYC kn-keyword=MYC en-keyword=rearrangements kn-keyword=rearrangements END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=3 article-no= start-page=55 end-page=59 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260315 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Low Temperature Formation of Dense Yttria-Stabilized Zirconia Layer Using Hot Isostatic Pressing kn-title=”MŠÔÃ…ˆ³‰Áˆ³–@‚ð—p‚¢‚½ƒCƒbƒgƒŠƒAˆÀ’艻ƒWƒ‹ƒRƒjƒAãk–§‘w‚̒ቷŒ`¬ en-subtitle= kn-subtitle= en-abstract= kn-abstract=The sintering conditions using hot isostatic press (HIP) of yttria-stabilized zirconia (YSZ) were investigated to obtain a dense YSZ layer at low sintering temperature such as 1000‹C for an electrolyte of metal-supported solid oxide fuel cell. It was found that a dense YSZ pellet with relative density of 93% could be obtained under a sintering condition of 1000‹C-10 hours with HIP in 195 MPa. On the other hand, in X-ray diffraction analysis of the dense YSZ pellet, peaks of the monoclinic phase were slightly detected in addition to peaks of the cubic phase. From energy dispersive X-ray spectroscopy analysis, a small amount of boron was detected in the dense YSZ pellet. It is considered that the YSZ crystalline phase transformation of cubic to monoclinic phase was occurred by the boron diffusion from the diffusion barrier coating of metal foil capsule used for the HIP. en-copyright= kn-copyright= en-aut-name=MANABEKyohei en-aut-sei=MANABE en-aut-mei=Kyohei kn-aut-name=^“ç‹•½ kn-aut-sei=^“ç kn-aut-mei=‹•½ aut-affil-num=1 ORCID= en-aut-name=ECHIGOMitsuaki en-aut-sei=ECHIGO en-aut-mei=Mitsuaki kn-aut-name=‰zŒã–žH kn-aut-sei=‰zŒã kn-aut-mei=–žH aut-affil-num=2 ORCID= en-aut-name=KISHIMOTOAkira en-aut-sei=KISHIMOTO en-aut-mei=Akira kn-aut-name=ŠÝ–{º kn-aut-sei=ŠÝ–{ kn-aut-mei=º aut-affil-num=3 ORCID= affil-num=1 en-affil=Osaka Gas Co. Ltd. kn-affil=‘åãƒKƒXiŠ”j affil-num=2 en-affil=Osaka Gas Co. Ltd. kn-affil=‘åãƒKƒXiŠ”j affil-num=3 en-affil=Institute of Academic and Research, Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŠwˆæ en-keyword=dense yttria-stabilized zirconia kn-keyword=dense yttria-stabilized zirconia en-keyword=hot isostatic press kn-keyword=hot isostatic press en-keyword=low sintering temperature kn-keyword=low sintering temperature en-keyword=electrolyte kn-keyword=electrolyte en-keyword=metal-supported solid oxide fuel cell kn-keyword=metal-supported solid oxide fuel cell END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=79 end-page=79 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒZƒ“ƒ^[•ñ“Še—v—Ì en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=75 end-page=78 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Ž‘—¿ : 2023”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=13 end-page=73 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰^‰c : 2023”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=11 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=’nˆæ˜AŒg : 2023”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=7 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ŽŽŒ±Œ¤‹† : 2023”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‹³ˆç : 2023”N“x en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=ii end-page=ii dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page=i end-page=i dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=˜ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆÀꌒˆê˜Y kn-aut-sei=ˆÀê kn-aut-mei=Œ’ˆê˜Y aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw”_Šw•”•‘®ŽR—zŒ—ƒtƒB[ƒ‹ƒh‰ÈŠwƒZƒ“ƒ^[ END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=37 cd-vols= no-issue=3 article-no= start-page=580 end-page=589 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260304 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Cysteine-Specific Cationization Strategy for Versatile Antibody Production against Intrinsically Disordered Proteins en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several autoantigens relevant to the immune system, especially those targeted by autoantibodies induced by antitumor responses, tend to be rich in disordered regions and are prone to aggregation. This inherent instability presents significant challenges for the production, purification, and analysis of autoantigens in laboratory settings. Cysteine-specific cationization can effectively solubilize and purify these challenging proteins, allowing the isolation of full-length water-soluble antigens in their denatured state. The purified antigens enable accurate multiplex autoantibody assays using a suspension Luminex bead array platform. However, well-validated positive control antibodies are essential to ensuring precise clinical diagnosis. In this study, we prepared and characterized a panel of control antibodies by immunizing rabbits with cysteine-specific S-cationized antigens. The resulting antibodies predominantly recognized linear epitopes and were highly effective as quality control reagents in autoantibody array assays. Additionally, these antibodies maintained their ability to bind to their native, unmodified intracellular counterparts, highlighting the usefulness of this approach for producing antibodies against intrinsically disordered proteins. Although a modest immune response against the S-cationized modification site was observed, it remained minimal and did not affect the usefulness of the antibodies for assay validation. We propose this versatile cysteine-specific cationization platform for managing unstable proteins rich in disordered regions, supporting antigen production for diagnostics, and antibody development for research and validation purposes. en-copyright= kn-copyright= en-aut-name=SakaguchiRyui en-aut-sei=Sakaguchi en-aut-mei=Ryui kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyamotoAi en-aut-sei=Miyamoto en-aut-mei=Ai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KutsumaRikako en-aut-sei=Kutsuma en-aut-mei=Rikako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoriTakeru en-aut-sei=Mori en-aut-mei=Takeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakashimaDaichi en-aut-sei=Nakashima en-aut-mei=Daichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MasuiMirei en-aut-sei=Masui en-aut-mei=Mirei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HonjoTomoko en-aut-sei=Honjo en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=FutamiMidori en-aut-sei=Futami en-aut-mei=Midori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MoriiMariko en-aut-sei=Morii en-aut-mei=Mariko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OshikiToshiyuki en-aut-sei=Oshiki en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=FutamiJunichiro en-aut-sei=Futami en-aut-mei=Junichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=8 en-affil=Department of Bioscience, Faculty of Life Science, Okayama University of Science kn-affil= affil-num=9 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=10 en-affil=Division of Applied Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=11 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=3 article-no= start-page=e202500639 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=PPy]Coated Wire Actuators for the Micromechanostimulation of Cells: Fabrication and Characterization en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cellular mechanotransduction signals play a crucial role in physiological and pathological conditions, including skeletal disorders. Although various systems exist to mechanically stimulate cultured cells, most are constrained by incubator incompatibility, limited physiological relevance, nonuniform stimulation, or complexity. The objective of this article is to develop and validate a compact, incubator-compatible tool capable of delivering localized and physiologically relevant mechanical stimulation to small cell populations. Here, we introduce a polypyrrole-based wire-shaped microactuator designed to induce localized mechanical stress to adjacent cells. These wire-shaped microactuators are biocompatible, easy-to-use, and compact for use within standard in vitro cell culture systems. Using a noncontact optical method, we characterize the actuation of polypyrrole-coated wires in an aqueous NaDBS electrolyte, showing radial expansion of 1.5?8??m depending on the deposited polypyrrole film thickness, comparable to cellular dimensions. Next, the actuation is confirmed to be robust and stable to use in cell culture media at physiological temperature. To evaluate biological relevance, osteoblastic KUSA-A1 cells are mechanically stimulated inside the incubator and transcriptomic changes are assessed. Mechanical stimulation resulted in upregulation of genes previously associated with mechanotransduction, including Fos and Fosb. Additionally, several uncharacterized long noncoding RNAs are differentially expressed, suggesting potential novel players in the mechanotransduction pathway. en-copyright= kn-copyright= en-aut-name=Ortega]SantosAmaia B. en-aut-sei=Ortega]Santos en-aut-mei=Amaia B. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HayanoSatoru en-aut-sei=Hayano en-aut-mei=Satoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HaraEmilio Satoshi en-aut-sei=Hara en-aut-mei=Emilio Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Mart?nezJose G. en-aut-sei=Mart?nez en-aut-mei=Jose G. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KamiokaHiroshi en-aut-sei=Kamioka en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=JagerEdwin W. H. en-aut-sei=Jager en-aut-mei=Edwin W. H. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Sensor and Actuator Systems, Department of Physics Chemistry and Biology (IFM), Link?ping University kn-affil= affil-num=2 en-affil=Department of Orthodontics, Okayama University Hospital kn-affil= affil-num=3 en-affil=Advanced Research Center for Oral and Craniofacial Sciences Dental School, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Sensor and Actuator Systems, Department of Physics Chemistry and Biology (IFM), Link?ping University kn-affil= affil-num=5 en-affil=Department of Orthodontics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Sensor and Actuator Systems, Department of Physics Chemistry and Biology (IFM), Link?ping University kn-affil= en-keyword=conducting polymers kn-keyword=conducting polymers en-keyword=mechanotransduction kn-keyword=mechanotransduction en-keyword=osteoblasts kn-keyword=osteoblasts en-keyword=polypyrrole kn-keyword=polypyrrole en-keyword=RNA sequencing kn-keyword=RNA sequencing en-keyword=soft-microactuators kn-keyword=soft-microactuators END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=1 article-no= start-page=bbag021 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=SGCRNA: spectral clustering-guided co-expression network analysis without scale-free constraints for multi-omic data en-subtitle= kn-subtitle= en-abstract= kn-abstract=Weighted gene co-expression network analysis (WGCNA) is among the most widely employed methods in bioinformatics. WGCNA enables the identification of gene clusters (modules) exhibiting correlated expression patterns, the association of these modules with traits, and the exploration of candidate biomarker genes by focusing on hub genes within the modules. WGCNA has been successfully applied in diverse biological contexts. However, conventional algorithms manifest three principal limitations: the assumption of scale-free topology, the requirement for parameter tuning, and the neglect of regression line slopes. These limitations are addressed by SGCRNA. SGCRNA provides Julia functions for the analysis of co-expression networks derived from various types of biological data, such as gene expression data. The Julia packages and their source code are freely available at https://github.com/C37H41N2O6/SGCRNAs.jl. en-copyright= kn-copyright= en-aut-name=OsoneTatsunori en-aut-sei=Osone en-aut-mei=Tatsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakaoTomoka en-aut-sei=Takao en-aut-mei=Tomoka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OtakeShigeo en-aut-sei=Otake en-aut-mei=Shigeo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TakaradaTakeshi en-aut-sei=Takarada en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= en-keyword=co-expression network analysis kn-keyword=co-expression network analysis en-keyword=multi-omics kn-keyword=multi-omics en-keyword=spectral clustering kn-keyword=spectral clustering END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=“Še‹K’öE‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=59 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical BIZEN Device Design Course Activity Report in Fiscal 2025 kn-title=2025 ”N“xŽŸ¢‘ãˆã—Ë@ŠíŠJ”­lވ笃vƒƒOƒ‰ƒ€ BIZEN ƒfƒoƒCƒXƒfƒUƒCƒ“ƒR[ƒX‚ÌŽæ‚è‘g‚Ý en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TSUZUKITsuneaki en-aut-sei=TSUZUKI en-aut-mei=Tsuneaki kn-aut-name=“s’zí–¾ kn-aut-sei=“s’z kn-aut-mei=í–¾ aut-affil-num=1 ORCID= en-aut-name=UCHIDADaisuke en-aut-sei=UCHIDA en-aut-mei=Daisuke kn-aut-name=“à“c‘å•ã kn-aut-sei=“à“c kn-aut-mei=‘å•ã aut-affil-num=2 ORCID= en-aut-name=KISHIMOTOToshio en-aut-sei=KISHIMOTO en-aut-mei=Toshio kn-aut-name=ŠÝ–{r•v kn-aut-sei=ŠÝ–{ kn-aut-mei=r•v aut-affil-num=3 ORCID= en-aut-name=SENGOKUYoshinari en-aut-sei=SENGOKU en-aut-mei=Yoshinari kn-aut-name=åΊì–ç kn-aut-sei=åÎ kn-aut-mei=Šì–ç aut-affil-num=4 ORCID= en-aut-name=KORENAGAToshio en-aut-sei=KORENAGA en-aut-mei=Toshio kn-aut-name=ˆÉ‰ir—Y kn-aut-sei=ˆÉ‰i kn-aut-mei=r—Y aut-affil-num=5 ORCID= en-aut-name=HITOBEYu en-aut-sei=HITOBE en-aut-mei=Yu kn-aut-name=l•”—F kn-aut-sei=l•” kn-aut-mei=—F aut-affil-num=6 ORCID= en-aut-name=YOSHIBAYasuyuki en-aut-sei=YOSHIBA en-aut-mei=Yasuyuki kn-aut-name=‹g—t‹±s kn-aut-sei=‹g—t kn-aut-mei=‹±s aut-affil-num=7 ORCID= en-aut-name=SAKURAIJun en-aut-sei=SAKURAI en-aut-mei=Jun kn-aut-name=ŸNˆä~ kn-aut-sei=ŸNˆä kn-aut-mei=~ aut-affil-num=8 ORCID= affil-num=1 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=2 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=3 en-affil=Organization for Research and Innovation Strategy, Okayama University kn-affil=‰ªŽR‘åŠw Œ¤‹†EƒCƒmƒx[ƒVƒ‡ƒ“‹¤‘n‹@\ affil-num=4 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=5 en-affil=Organization for Research and Innovation Strategy, Okayama University kn-affil=‰ªŽR‘åŠw Œ¤‹†EƒCƒmƒx[ƒVƒ‡ƒ“‹¤‘n‹@\ affil-num=6 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=7 en-affil=Academic Field of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=8 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=49 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Advanced Hospital Training Activities in Fiscal 2025 kn-title=2025 ”N“x‚É‚¨‚¯‚éuæi•a‰@ŽÀKv‚ÌŽæ‚è‘g‚Ý en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MORITAMizuki en-aut-sei=MORITA en-aut-mei=Mizuki kn-aut-name=X“cŽ÷ kn-aut-sei=X“c kn-aut-mei=Ž÷ aut-affil-num=1 ORCID= en-aut-name=MAGARIMasaki en-aut-sei=MAGARI en-aut-mei=Masaki kn-aut-name=‹È³Ž÷ kn-aut-sei=‹È kn-aut-mei=³Ž÷ aut-affil-num=2 ORCID= en-aut-name=WangJin en-aut-sei=Wang en-aut-mei=Jin kn-aut-name=‰¤? kn-aut-sei=‰¤ kn-aut-mei=? aut-affil-num=3 ORCID= en-aut-name=WATANABEToyohiko en-aut-sei=WATANABE en-aut-mei=Toyohiko kn-aut-name=“nç³–L•F kn-aut-sei=“nç³ kn-aut-mei=–L•F aut-affil-num=4 ORCID= en-aut-name=OITAMasataka en-aut-sei=OITA en-aut-mei=Masataka kn-aut-name=‹ˆ“c«c kn-aut-sei=‹ˆ“c kn-aut-mei=«c aut-affil-num=5 ORCID= en-aut-name=HARADANahoko en-aut-sei=HARADA en-aut-mei=Nahoko kn-aut-name=Œ´“c“Þ•äŽq kn-aut-sei=Œ´“c kn-aut-mei=“Þ•äŽq aut-affil-num=6 ORCID= en-aut-name=SHISHIDOKeisuke en-aut-sei=SHISHIDO en-aut-mei=Keisuke kn-aut-name=Ž³ŒËŒ\‰î kn-aut-sei=Ž³ŒË kn-aut-mei=Œ\‰î aut-affil-num=7 ORCID= affil-num=1 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=2 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=3 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=4 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=5 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=6 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ affil-num=7 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=39 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Narrative Review on Motivation and Evaluation of Community Residents regarding Advance Care Planning in Japan kn-title=‚킪‘‚̃Aƒhƒoƒ“ƒXEƒPƒAEƒvƒ‰ƒ“ƒjƒ“ƒO‚É‚¨‚¯‚é’nˆæZ–¯‚Ö‚Ì“®‹@‚¯‚Æ•]‰¿‚ɂ‚¢‚Ẵiƒ‰ƒeƒBƒuEƒŒƒrƒ…[ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HASUITakako en-aut-sei=HASUI en-aut-mei=Takako kn-aut-name=˜@ˆä‹MŽq kn-aut-sei=˜@ˆä kn-aut-mei=‹MŽq aut-affil-num=1 ORCID= en-aut-name=NAKAYAMANaoko en-aut-sei=NAKAYAMA en-aut-mei=Naoko kn-aut-name=’†ŽR’¼Žq kn-aut-sei=’†ŽR kn-aut-mei=’¼Žq aut-affil-num=2 ORCID= affil-num=1 en-affil=Japanese Red Cross Hokkaido College of Nursing kn-affil=“ú–{Ô\Žš–kŠC“¹ŠÅŒì‘åŠw affil-num=2 en-affil=Kanagawa University of Human Services kn-affil=_“Þ쌧—§•ÛŒ’•ŸŽƒ‘åŠw END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=27 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Historical Changes in HIV Testing Technologies and Japan's HIV Testing System kn-title=HIV ŒŸ¸‹Zp‚Æ“ú–{‚É‚¨‚¯‚é HIV ŒŸ¸‘̧‚Ì•Ï‘J en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WANGDecheng en-aut-sei=WANG en-aut-mei=Decheng kn-aut-name=ŸŠ“¿¬ kn-aut-sei=ŸŠ kn-aut-mei=“¿¬ aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†‰È en-keyword=HIV kn-keyword=HIV en-keyword=HIV testing kn-keyword=HIV testing en-keyword=HIV testing technologies kn-keyword=HIV testing technologies en-keyword=HIV testing system kn-keyword=HIV testing system en-keyword=Japan kn-keyword=Japan END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=17 end-page=25 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Patient Participation in Shared Decision-Making: A Consideration of Aspects and Challenges kn-title=Shared Decision Making ‚É‚¨‚¯‚銳ŽÒŽQ‰Á‚Ì”‘Š‚Ɖۑè‚ÌlŽ@ en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper traces the historical development of decision-making models in healthcare while exploring the meaning and practical significance of gpatient participationh within the shared decision-making (SDM) framework. SDM is a recommended approach to clinical decision-making that emphasizes mutual information sharing and deliberation between physicians and patients. Traditional models often assume that patients can clearly articulate their values, preferences, and treatment goals. However, in actual clinical settings, particularly in cases of serious illness or life-threatening situations, patients frequently face emotional distress and psychological burdens, which can hinder their active participation in decision-making and the expression of their preferences. Based on SDM theory and practice reports, this study argues that SDM should not be viewed merely as a process that promotes patient choice. Even when patients choose not to actively participate and ultimately delegate decisions to healthcare providers or family members, such a choice can represent autonomous decision-making if it arises through meaningful communication and mutual understanding. This perspective calls for a more comprehensive and flexible interpretation of patient participation in SDM practice. en-copyright= kn-copyright= en-aut-name=YOSHIDAMiho en-aut-sei=YOSHIDA en-aut-mei=Miho kn-aut-name=‹g“c”ü•ä kn-aut-sei=‹g“c kn-aut-mei=”ü•ä aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Interdisciplinary Science and Engineering in Health Systems Okayama University kn-affil=‘—§‘åŠw–@l‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŒ¤‹†Šwˆæ en-keyword=Shared Decision-Making kn-keyword=Shared Decision-Making en-keyword=Patient Participation kn-keyword=Patient Participation en-keyword=Physician?Patient Relationship kn-keyword=Physician?Patient Relationship END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=7 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Preliminary Study on Nursing Care Technology: A Case Study of Elderly Care kn-title=‰îŒì‹Zp˜_ŽŽ˜_\‚—îŽÒ‰îŒì‚ðŽ–—á‚Æ‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the first part of this paper, it was confirmed that the term gkaigoh (nursing care) was coined and its meaning defined during discussions on enacting social welfare legislation accompanying societal aging, as the care aspect was being gdifferentiatedh from the gfamilyfs health and welfare functions.h The paper also examined how the term gkaigo gijutsuh(nursing care technique) has been defined and used. In the latter part, based on the authorfs own definition of gkaigo gijutsuh(nursing care technology), an attempt was made to analyze examples of technology utilization in nursing care settings, focusing on papers published in specialized welfare and nursing care technology journals. Through this preliminary study, it was shown that the authorfs definition of gnursing care technologyh clearly distinguishes between the means for care activities?such as welfare equipment?and the care recipients and caregivers who make use of them, and that this definition is useful for grasping the essence of challenges in nursing care settings. en-copyright= kn-copyright= en-aut-name=YOSHIBAYasuyuki en-aut-sei=YOSHIBA en-aut-mei=Yasuyuki kn-aut-name=‹g—t‹±s kn-aut-sei=‹g—t kn-aut-mei=‹±s aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ƒwƒ‹ƒXƒVƒXƒeƒ€“‡‰ÈŠwŠwˆæ en-keyword=Nursing Care Technology kn-keyword=Nursing Care Technology en-keyword=Elderly Care kn-keyword=Elderly Care en-keyword=welfare equipment kn-keyword=welfare equipment END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=1 end-page=6 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The effects of cold compresses on itching in patients with atopic dermatitis: A cross-over controlled pilot trial en-subtitle= kn-subtitle= en-abstract= kn-abstract=This cross-over controlled trial aimed to evaluate the effectiveness and safety of two types of cold compresses (towels and ice packs) in alleviating itching among patients with atopic dermatitis. The study recruited 19 participants diagnosed with atopic dermatitis and suffering from chronic itching for over 6 months. Each participant received both types of cold compress interventions. Itching sensations were assessed repeatedly using a visual analogue scale before and after the application of the cold compress. The mean and standard deviation of itching scores for the towel intervention were 16.9 } 19.1 (baseline) and 11.4 } 16.1 (post-application). For the ice pack intervention, the scores were 13.6 } 14.7 (baseline) and 6.2 } 9.8 (post-application). Although there was a reduction in mean itching scores following the application of cold compresses, the differences were not statistically significant for either intervention. Despite the lack of statistical significance, this study suggests that cold compresses, which are user-friendly and inexpensive, may safely reduce subjective itching in patients with atopic dermatitis without causing pain or discomfort. However, further research with a larger sample size is needed to confirm these findings. en-copyright= kn-copyright= en-aut-name=HIRAMIYuki en-aut-sei=HIRAMI en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HARADANahoko en-aut-sei=HARADA en-aut-mei=Nahoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ONOMiho en-aut-sei=ONO en-aut-mei=Miho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KODAMasahide en-aut-sei=KODA en-aut-mei=Masahide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FUKAIKiyoko en-aut-sei=FUKAI en-aut-mei=Kiyoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Former Department of Nursing, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Nursing Science, Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=3 en-affil=Department of Nursing, Faculty of Health, Kagawa Prefectural University of Health Sciences kn-affil= affil-num=4 en-affil=Co-learning Community Healthcare Re-innovation Office, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Professor Emeritus, Okayama University, Graduate School of Nursing, The Jikei University School of Medicine kn-affil= en-keyword=Atopic Dermatitis kn-keyword=Atopic Dermatitis en-keyword=Pruritus kn-keyword=Pruritus en-keyword=Cryotherapy kn-keyword=Cryotherapy en-keyword=Quality of Life kn-keyword=Quality of Life en-keyword=Skin Temperature kn-keyword=Skin Temperature END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=2025 cd-vols= no-issue= article-no= start-page=9884345 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251120 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparing the Activity of Peripheral Blood Mononuclear Cells Frozen Under Electromagnetic Field Freezing and Standard Slow-Freezing en-subtitle= kn-subtitle= en-abstract= kn-abstract=Peripheral blood mononuclear cells (PBMCs) are cells obtained from the blood that are used not only in clinical tests but also in various research applications. The slow-freezing (SLF) method, currently the standard for PBMC cryopreservation, involves extended storage at ?80‹C before transfer to liquid nitrogen. Delays in this transfer, such as overnight or weekend holds, risk a gradual decline in cell viability. Additionally, variability in freezing duration can lead to inconsistent cell quality, emphasizing the need for an alternative freezing method that allows for more timely transfer to liquid nitrogen. This study is aimed at clarifying whether the method of using a freezer with an applied electromagnetic field (EMF) is superior to the currently used standard SLF method for PBMC cryopreservation. A comparison of the number of viable cells, cell viability, and cell activity showed that the EMF method was equivalent to the SLF method. However, the shortest time required for freezing was significantly shorter with the EMF method than the SLF method (0.25 vs. 3?h), allowing for earlier transfer of PBMC to liquid nitrogen. This demonstrates that the EMF method offers an advantage in operational efficiency, particularly for facilities that routinely process and store PBMCs, such as biobanks and other storage-focused departments. en-copyright= kn-copyright= en-aut-name=MatsubaraTakehiro en-aut-sei=Matsubara en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakagiMina en-aut-sei=Takagi en-aut-mei=Mina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=UwaboTakahiro en-aut-sei=Uwabo en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SohJunichi en-aut-sei=Soh en-aut-mei=Junichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MoritaMizuki en-aut-sei=Morita en-aut-mei=Mizuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Okayama University Hospital Biobank kn-affil= affil-num=2 en-affil=Faculty of Health Sciences, Okayama University Medical School kn-affil= affil-num=3 en-affil=Department of Biorepository Research and Networking, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Thoracic Surgery, Osaka Metropolitan University Graduate School of Medicine kn-affil= affil-num=5 en-affil=Okayama University Hospital Biobank kn-affil= affil-num=6 en-affil=Okayama University Hospital Biobank kn-affil= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=8840 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260317 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Tribolium castaneum with longer duration of tonic immobility have more variations corresponding to the human Parkinsonfs disease genomic region en-subtitle= kn-subtitle= en-abstract= kn-abstract=Parkinsonfs disease (PD) is a common neurodegenerative syndrome characterized by the loss of dopaminergic neurons and is also a progressive neurodegenerative disorder that is characterized by dopamine deficiency. We established strains artificially selected for longer and shorter durations of tonic immobility, an antipredator behavior that has received much attention recently, in the red flour beetle, Tribolium castaneum, a model insect species for molecular analyses different from Drosophila melanogaster. Previous studies have shown that the long strains (L-strain) have significantly lower levels of dopamine expression in the brain than the short strains (S-strain) and that they have an abnormal pattern of locomotor activity. Furthermore, previous studies have shown that administering dopamine to L-strain beetles reduces the duration of tonic immobility. Transcriptome analysis of brain and thorax of the L- and S-strains also showed differences in mRNA expression of genes involved in dopamine synthesis and tyrosine metabolism. These results indicate that the phenotype and molecular basis of the L-strain are similar to those of Parkinsonfs syndrome symptoms. In order to establish a link between T. castaneum and PD, we compared the DNA sequences of the L- and S-strains to human genes affecting dopaminergic pathways. The DNA comparison revealed many mutated regions in these genes in the L-strain. We discuss the relationship between dopaminergic pathway genes and PD-like phenotypes across humans, Drosophila, and the red flour beetle. en-copyright= kn-copyright= en-aut-name=TanakaKeisuke en-aut-sei=Tanaka en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SasakiKen en-aut-sei=Sasaki en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YajimaShunsuke en-aut-sei=Yajima en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyatakeTakahisa en-aut-sei=Miyatake en-aut-mei=Takahisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=NODAI Genome Research Center, Tokyo University of Agriculture kn-affil= affil-num=2 en-affil=Graduate School of Agriculture, Tamagawa University kn-affil= affil-num=3 en-affil=NODAI Genome Research Center, Tokyo University of Agriculture kn-affil= affil-num=4 en-affil=Faculty of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page=(48) end-page=(60) dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=u‚Ú‚Á‚¯‚¦v‚Æu‚Å‚¦‚ꂦv\“¯‹`“I—Þ‹`Œê‚̈Ӗ¡—p–@‚Ì•ªÍ\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‹g“c‘¥•v kn-aut-sei=‹g“c kn-aut-mei=‘¥•v aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page=(37) end-page=(47) dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=že–ì_ˆêwÎì‚­‚ñx‚ÉŠw‚Ô‰C•¶‚Ì‘‚«Š·‚¦ \•¶–@‚ÆŒêœb‚Ì‘I‘ð‚ª‚à‚½‚ç‚·•\Œ»‚Ì‘ÎÆ«\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=–”‹g—¢”ü kn-aut-sei=–”‹g kn-aut-mei=—¢”ü aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page=(23) end-page=(36) dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=º˜a‰Šú‚É‚¨‚¯‚鋽“y‘Œê“Ç–{‚ÌŒŸ“¢ \ˆ°“cŒb”V•‚ÆŒq‚ª‚è‚Ì[‚¢‰F˜a“‡˜a—ìqí¬ŠwZ‚É‚¨‚¯‚é“Ç–{•ÒŽ[\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=’r“c‹§Žj kn-aut-sei=’r“c kn-aut-mei=‹§Žj aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page=(13) end-page=(22) dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ꌟ‘Œê‰È‚ÌŽŽŒ±–â‘è \“ˆê–â‘è‚É‚Ý‚é’†ŠwZ‘Œê‰È‚Ì‹³‰È“à—e\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=•‚“c^‹| kn-aut-sei=•‚“c kn-aut-mei=^‹| aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page=(1) end-page=(12) dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ŒP“ÇŠ¿Ž‚̉¹“ǂɂ‚¢‚Ä \‰¹“Ç‘ä–{‚Ì‚·‚·‚ß\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=“y‰®‘ kn-aut-sei=“y‰® kn-aut-mei=‘ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page=42 end-page=45 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=sŽ„‚Ì‘Œê‹³Žºt@u‘¦À‚Ì•\Œ»—Ív‚Ìˆç¬ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ÎX‘n‘¾ kn-aut-sei=ÎX kn-aut-mei=‘n‘¾ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page=35 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=¶¬‚`‚h‚Ìu‚à‚Á‚Æ‚à‚炵‚³v‚ð–â‚¢’¼‚· \o“T‚É—§‚¿•Ô‚éŠwK‚ð’Ê‚¶‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¬ŽRáÁŽq kn-aut-sei=¬ŽR kn-aut-mei=áÁŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=•ºŒÉŒ§—§ŽO–Ø“ŒE ŽO–Ø‘‡‚“™ŠwZ END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page=18 end-page=34 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‘å’ÃcŽq‚ÆÎì˜Y—‚Ì‘¡“š‰Ì \“ü–勳ނƂµ‚Ă̌ÓT˜a‰Ì\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼“c‘ kn-aut-sei=¼“c kn-aut-mei=‘ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page=1 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=˜DvuŒÌ‹½v˜_ \q‚‚¢•Çr‚Ì’†‚ÌuŽ„v\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=–Ø‘ºŒ÷ kn-aut-sei=–Ø‘º kn-aut-mei=Œ÷ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=119 cd-vols= no-issue=1 article-no= start-page=9 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202507 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Big data-driven target identification by machine learning: DRD2 as a therapeutic target for psoriasis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: The development of medical treatments has traditionally relied on researchers leveraging scientific knowledge to hypothesize disease mechanisms and identify therapeutic agents. However, the depletion of novel therapeutic targets has become a significant challenge, resulting in stagnation within pharmaceutical research.
Objective: To address the scarcity of therapeutic targets, we developed a machine learning (ML)-based system capable of predicting therapeutic target molecules for diseases. To validate its utility, we applied this system to psoriasis, aiming to identify novel treatment strategies.
Methods: Our approach utilized a large clinical database to calculate reporting odds ratios for all drugs associated with the prevention of diseases of interest. We identified target proteins by analyzing large chemical structure databases to discover proteins commonly associated with preventive drug candidates. Experimental validation was conducted by administering a predicted therapeutic candidate in an imiquimod-induced psoriasis mouse model.
Results: The ML-based predictions identified drugs for Parkinsonfs disease as potential preventive candidates for psoriasis. Further analysis highlighted dopamine receptor D2 (DRD2) as a therapeutic target. Administration of a DRD2 agonist alleviated psoriasis symptoms in mice, evidenced by the downregulation of mRNA expression in the IL-17 pathway and reduced serum tumor necrosis factor-ƒ¿ levels.
Conclusion: This study demonstrates the utility of a novel ML-based system for identifying therapeutic targets, as shown by its successful application in uncovering the role of DRD2 in psoriasis. Beyond psoriasis, this system offers significant potential for exploring pathological mechanisms and discovering therapeutic targets across various diseases. en-copyright= kn-copyright= en-aut-name=SakaiTakashi en-aut-sei=Sakai en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SawadaRyusuke en-aut-sei=Sawada en-aut-mei=Ryusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IchinoseOtoha en-aut-sei=Ichinose en-aut-mei=Otoha kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TerabayashiTakeshi en-aut-sei=Terabayashi en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HatanoYutaka en-aut-sei=Hatano en-aut-mei=Yutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YamanishiYoshihiro en-aut-sei=Yamanishi en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IshizakiToshimasa en-aut-sei=Ishizaki en-aut-mei=Toshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Dermatology, Faculty of Medicine, Oita University kn-affil= affil-num=2 en-affil=Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Bioscience and Bioinformatics, Faculty of Computer Science and Systems Engineering, Kyushu Institute of Technology kn-affil= affil-num=4 en-affil=Department of Pharmacology, Faculty of Medicine, Oita University kn-affil= affil-num=5 en-affil=Department of Dermatology, Faculty of Medicine, Oita University kn-affil= affil-num=6 en-affil=Department of Complex Systems Science, Graduate School of Informatics, Nagoya University kn-affil= affil-num=7 en-affil=Department of Pharmacology, Faculty of Medicine, Oita University kn-affil= en-keyword=artificial intelligence kn-keyword=artificial intelligence en-keyword=big data kn-keyword=big data en-keyword=machine learning kn-keyword=machine learning en-keyword=dopamine receptor D2 kn-keyword=dopamine receptor D2 en-keyword=psoriasis kn-keyword=psoriasis END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=9 article-no= start-page=14570 end-page=14577 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Water-Resistant Antibacterial Coatings Using Cetylpyridinium Chloride - Graphene Oxide Composites en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hospital-acquired infections remain a persistent threat in healthcare settings, especially with the increasing number of elderly and immunocompromised patients. In situations where the use of disposable materials is difficult, durable antibacterial surface coatings are essential. In this study, we report the structural characterization of cetylpyridinium chloride-graphene oxide (CPC?GO) hybrid materials and the sustainability of their antibacterial effects, aiming at washable antibacterial coatings for medical applications. Graphene oxide (GO) has a large surface area and numerous functional groups, while cetylpyridinium chloride (CPC) is a quaternary ammonium compound with well-documented antibacterial activity. We hypothesized that the stable incorporation of CPC through the functional groups of GO could improve surface retention and provide long-term antibacterial performance. The structural properties of the CPC?GO composites were characterized by UV?vis spectroscopy, X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, and atomic force microscopy. These analyses confirmed the formation of a complex through ionic bonds and the maintenance of a planar composite structure. The antibacterial performance of the CPC?GO coatings was examined using representative bacteria. Notably, the CPC?GO coatings maintained their antibacterial activity significantly better than the negative controls even after multiple washings. The excellent surface retention of the CPC?GO composite suggests its potential as a next-generation antibacterial coating for areas where disinfection and sterilization are impossible, such as the interior of complex medical devices. This study suggests a strategy to extend the efficacy of existing antibacterial agents through the application of nanomaterials. Future studies will focus on the controlled release, long-term stability, and biocompatibility of CPC to realize clinical applications. en-copyright= kn-copyright= en-aut-name=OkuboKeisuke en-aut-sei=Okubo en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KanoGen en-aut-sei=Kano en-aut-mei=Gen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KomodaMasato en-aut-sei=Komoda en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OmoriKazuhiro en-aut-sei=Omori en-aut-mei=Kazuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NishinaYuta en-aut-sei=Nishina en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TakashibaShogo en-aut-sei=Takashiba en-aut-mei=Shogo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Department of Periodontics and Endodontics, Field of Medical Development, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Pathophysiology - Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=6 en-affil=Department of Pathophysiology - Periodontal Science, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=6 article-no= start-page=845 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Seasonal Variations in the Risk of Outpatient Acute Kidney Injury in Patients with Chronic Kidney Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background/Objectives: Acute kidney injury (AKI) frequently occurs in the outpatient setting and is associated with adverse renal and survival outcomes. However, there is no established definition of outpatient AKI, and the risk factors, especially seasonal variation, remain limited. This study aimed to investigate seasonal variation in the risk of outpatient AKI. Methods: This retrospective observational study used routinely collected clinical laboratory data from a single hospital in Japan between 2007 and 2022. Outpatient AKI was defined as ?35% relative decline in estimated glomerular filtration rate (eGFR) compared with a preceding outpatient measurement obtained within 14?90 days. Monthly and seasonal variations in outpatient AKI risk in patients with chronic kidney disease (CKD) were evaluated using logistic regression models. Subgroup analyses were performed according to AKI stage, age group, and CKD stage. Results: A total of 203,853 outpatient records were analyzed. The incidence of outpatient AKI was highest in August and lowest in November. Analyses demonstrated significantly increased odds ratios of outpatient AKI in January, February, July, and August. Seasonally, the risk was significantly higher during the summer. Stage-specific analyses showed that AKI stage 1 was more frequent in the summer, whereas AKI stage 2 tended to increase during the winter. Conclusions: Outpatient AKI exhibits distinct seasonal patterns, with increased risk during both summer and winter and differential associations according to AKI severity and baseline kidney function. Recognition of these patterns may help identify vulnerable populations and inform targeted preventive strategies for outpatient AKI. en-copyright= kn-copyright= en-aut-name=NakanohHiroyuki en-aut-sei=Nakanoh en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsujiKenji en-aut-sei=Tsuji en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FukushimaKazuhiko en-aut-sei=Fukushima en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UchidaNaruhiko en-aut-sei=Uchida en-aut-mei=Naruhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HaraguchiSoichiro en-aut-sei=Haraguchi en-aut-mei=Soichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KitamuraShinji en-aut-sei=Kitamura en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=acute kidney injury kn-keyword=acute kidney injury en-keyword=chronic kidney disease kn-keyword=chronic kidney disease en-keyword=outpatients kn-keyword=outpatients en-keyword=seasons kn-keyword=seasons END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=6 article-no= start-page=657 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Adolescent screen use in the pre-internet era and subsequent health and well-being: an outcome-wide longitudinal study en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study used data from the National Longitudinal Study of Adolescent to Adult Health (Add Health, N?=?11,054) to assess whether increases in screen-based leisure during adolescence (Wave II, from 1996) predicted adult well-being (Wave IV, from 2008-09), adjusting for a wide range of covariates (Wave I, from 1995). Using an outcome-wide analytic approach, we examined associations between screen time and 38 adult outcomes, adjusting for prior screen time, values of most outcomes, and confounders. Most associations were null. Modest evidence was found for links between screen time (continuous) and reduced sense of control, illicit drug use, and allostatic load. High screen time (14 h/week) or more also showed weak associations with lower depression and preventive care use. Because the data predate widespread internet use, the findings help establish a baseline for the long-term effects of non-internet screen activities, which appeared to behave had limited impact on adult health and well-being. en-copyright= kn-copyright= en-aut-name=de la Rosa Fern?ndez-PachecoPedro Antonio en-aut-sei=de la Rosa Fern?ndez-Pacheco en-aut-mei=Pedro Antonio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=WilkinsonRenae en-aut-sei=Wilkinson en-aut-mei=Renae kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=CowdenRichard G. en-aut-sei=Cowden en-aut-mei=Richard G. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ChenYing en-aut-sei=Chen en-aut-mei=Ying kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=CaseBrendan en-aut-sei=Case en-aut-mei=Brendan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SuzukiEtsuji en-aut-sei=Suzuki en-aut-mei=Etsuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=VanderWeeleTyler J. en-aut-sei=VanderWeele en-aut-mei=Tyler J. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Youth in Transition, Institute for Culture and Society, Universidad de Navarra kn-affil= affil-num=2 en-affil=Human Flourishing Program, Institute for Quantitative Social Science, Harvard University kn-affil= affil-num=3 en-affil=Human Flourishing Program, Institute for Quantitative Social Science, Harvard University kn-affil= affil-num=4 en-affil=Human Flourishing Program, Institute for Quantitative Social Science, Harvard University kn-affil= affil-num=5 en-affil=Human Flourishing Program, Institute for Quantitative Social Science, Harvard University kn-affil= affil-num=6 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Epidemiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Leisure kn-keyword=Leisure en-keyword=Television kn-keyword=Television en-keyword=Outcome-wide epidemiology kn-keyword=Outcome-wide epidemiology en-keyword=Video games kn-keyword=Video games en-keyword=Adolescence kn-keyword=Adolescence en-keyword=Well-being kn-keyword=Well-being END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=2 article-no= start-page=dmm052605 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A genetic model of congenital intestinal atresia implicates Mypt1 in epithelial organisation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Congenital intestinal atresia (IA) is a birth defect characterised by the absence or closure of part of the intestine. Although genetic factors are implicated, mechanistic understanding has been hindered by the lack of suitable animal models. Here, we describe a medaka (Oryzias latipes) mutant, generated by N-ethyl-N-nitrosourea (ENU) mutagenesis, that develops IA during embryogenesis. Positional cloning identified a nonsense mutation in mypt1, encoding myosin phosphatase target subunit 1. Mutant embryos exhibited ectopic accumulation of F-actin and phosphorylated myosin regulatory light chain (Mrlc) in the intestinal epithelium, consistent with disrupted actomyosin regulation. These cytoskeletal abnormalities were accompanied by epithelial disorganisation, without notable alterations in cell proliferation, motility or apoptosis. Inhibition of myh11a, encoding smooth muscle (SM) myosin heavy chain, ameliorated the IA phenotype, whereas blebbistatin treatment completely rescued the defect, suggesting a non-contractile role prior to SM maturation. Together, these findings demonstrate that mypt1 loss disrupts intestinal morphogenesis through actomyosin dysregulation. Given the recent clinical identification of IA associated with MYPT1 variants, this medaka model offers a valuable platform to investigate the developmental and molecular basis of MYPT1-associated IA in humans. en-copyright= kn-copyright= en-aut-name=KobayashiDaisuke en-aut-sei=Kobayashi en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UrasakiAkihiro en-aut-sei=Urasaki en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KimuraTetsuaki en-aut-sei=Kimura en-aut-mei=Tetsuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AnsaiSatoshi en-aut-sei=Ansai en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsuoKazuhiko en-aut-sei=Matsuo en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YokoiHayato en-aut-sei=Yokoi en-aut-mei=Hayato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakashimaShigeo en-aut-sei=Takashima en-aut-mei=Shigeo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KitagawaTadao en-aut-sei=Kitagawa en-aut-mei=Tadao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KageTakahiro en-aut-sei=Kage en-aut-mei=Takahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=NaritaTakanori en-aut-sei=Narita en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=JindoTomoko en-aut-sei=Jindo en-aut-mei=Tomoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=KinoshitaMasato en-aut-sei=Kinoshita en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=NaruseKiyoshi en-aut-sei=Naruse en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=NakajimaYoshiro en-aut-sei=Nakajima en-aut-mei=Yoshiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=ShigetaMasaki en-aut-sei=Shigeta en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=SakakiShinichiro en-aut-sei=Sakaki en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=InoueSatoshi en-aut-sei=Inoue en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=SabaRie en-aut-sei=Saba en-aut-mei=Rie kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=YamadaKei en-aut-sei=Yamada en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=YokoyamaTakahiko en-aut-sei=Yokoyama en-aut-mei=Takahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=IshikawaYuji en-aut-sei=Ishikawa en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=ArakiKazuo en-aut-sei=Araki en-aut-mei=Kazuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= en-aut-name=SagaYumiko en-aut-sei=Saga en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=23 ORCID= en-aut-name=TakedaHiroyuki en-aut-sei=Takeda en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=24 ORCID= en-aut-name=YashiroKenta en-aut-sei=Yashiro en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=25 ORCID= affil-num=1 en-affil=Department of Anatomy and Developmental Biology, Kyoto Prefectural University of Medicine kn-affil= affil-num=2 en-affil=Department of Anatomy and Developmental Biology, Kyoto Prefectural University of Medicine kn-affil= affil-num=3 en-affil=Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology kn-affil= affil-num=4 en-affil=Ushimado Marine Institute, Okayama University kn-affil= affil-num=5 en-affil=Department of Anatomy and Developmental Biology, Kyoto Prefectural University of Medicine kn-affil= affil-num=6 en-affil=Graduate School of Agricultural Science, Tohoku University kn-affil= affil-num=7 en-affil=Institute for Glyco-core Research (iGCORE)/Life Science Research Centre, Gifu University kn-affil= affil-num=8 en-affil=Program in Environmental Management, Graduate School of Agriculture, Kindai University kn-affil= affil-num=9 en-affil=Department of Biological Sciences, Graduate School of Science, The University of Tokyo kn-affil= affil-num=10 en-affil=Laboratory of Molecular Biology, Department of Veterinary Medicine, College of Bioresource Sciences, Nihon University kn-affil= affil-num=11 en-affil=Department of Biological Sciences, Graduate School of Science, The University of Tokyo kn-affil= affil-num=12 en-affil=Department of Applied Biosciences, Graduate School of Agriculture, Kyoto University kn-affil= affil-num=13 en-affil=Laboratory of Bioresources, National Institute for Basic Biology kn-affil= affil-num=14 en-affil=Department of Anatomy and Developmental Biology, Kyoto Prefectural University of Medicine kn-affil= affil-num=15 en-affil=Department of Anatomy and Developmental Biology, Kyoto Prefectural University of Medicine kn-affil= affil-num=16 en-affil=Department of Anatomy and Developmental Biology, Kyoto Prefectural University of Medicine kn-affil= affil-num=17 en-affil=Department of Anatomy and Developmental Biology, Kyoto Prefectural University of Medicine kn-affil= affil-num=18 en-affil=Department of Radiology, Kyoto Prefectural University of Medicine kn-affil= affil-num=19 en-affil=Department of Radiology, Kyoto Prefectural University of Medicine kn-affil= affil-num=20 en-affil=Department of Anatomy and Developmental Biology, Kyoto Prefectural University of Medicine kn-affil= affil-num=21 en-affil=Research Centre for Radiation Protection, National Institute of Radiological Sciences kn-affil= affil-num=22 en-affil=Research Center for Aquatic Breeding, National Research Institute of Aquaculture, Fisheries Research Agency kn-affil= affil-num=23 en-affil=Department of Biological Sciences, Graduate School of Science, The University of Tokyo kn-affil= affil-num=24 en-affil=Department of Biological Sciences, Graduate School of Science, The University of Tokyo kn-affil= affil-num=25 en-affil=Department of Anatomy and Developmental Biology, Kyoto Prefectural University of Medicine kn-affil= en-keyword=Intestinal atresia kn-keyword=Intestinal atresia en-keyword=Mypt1 kn-keyword=Mypt1 en-keyword=Disease model kn-keyword=Disease model en-keyword=Actomyosin regulation kn-keyword=Actomyosin regulation en-keyword=Intestinal development kn-keyword=Intestinal development END start-ver=1.4 cd-journal=joma no-vol=18 cd-vols= no-issue= article-no= start-page=102828 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202511 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Development of FTase inhibitors inspired by the structures of andrastins en-subtitle= kn-subtitle= en-abstract= kn-abstract=We designed and synthesized structurally simple farnesyl transferase (FTase) inhibitors (1a?1d) by leveraging andrastin, a natural product with FTase inhibitory activity. 1a?1d possess a cyclopentane-1,3-dione core, which is critical for FTase recognition; a farnesyl moiety, which is a simplified motif of A to C rings of andrastin; and a carboxylic acid or methoxycarbonyl group, which enables multipoint hydrogen bonding interactions with FTase. Competitive inhibition experiments revealed that 1d has the most potent FTase inhibitory activity. Docking simulation analysis of 1a?1d with FTase suggested that the multipoint hydrogen bonding interactions between the cyclopentane-1,3-dione moiety and the carboxyl group play an important role in FTase recognition. en-copyright= kn-copyright= en-aut-name=KitamuraFumino en-aut-sei=Kitamura en-aut-mei=Fumino kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TaniokaMasaru en-aut-sei=Tanioka en-aut-mei=Masaru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KosakaAyano en-aut-sei=Kosaka en-aut-mei=Ayano kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MatsuzawaNao en-aut-sei=Matsuzawa en-aut-mei=Nao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ObitaTakayuki en-aut-sei=Obita en-aut-mei=Takayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SakajiriYuko en-aut-sei=Sakajiri en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ShibataTomokazu en-aut-sei=Shibata en-aut-mei=Tomokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SawadaRyusuke en-aut-sei=Sawada en-aut-mei=Ryusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YokoyamaTakeshi en-aut-sei=Yokoyama en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KohyamaAki en-aut-sei=Kohyama en-aut-mei=Aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamadaTsuyoshi en-aut-sei=Yamada en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YamanishiYoshihiro en-aut-sei=Yamanishi en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MizuguchiMineyuki en-aut-sei=Mizuguchi en-aut-mei=Mineyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MatsuyaYuji en-aut-sei=Matsuya en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=2 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=3 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=4 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=5 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=6 en-affil= kn-affil= affil-num=7 en-affil=Department of Complex Systems Science, Graduate School of Informatics, Nagoya University kn-affil= affil-num=8 en-affil=Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=10 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=11 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=12 en-affil=Department of Complex Systems Science, Graduate School of Informatics, Nagoya University kn-affil= affil-num=13 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= affil-num=14 en-affil=Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama kn-affil= en-keyword=Andrastin analogs kn-keyword=Andrastin analogs en-keyword=Farnesyl transferase (FTase) inhibitor kn-keyword=Farnesyl transferase (FTase) inhibitor en-keyword=Hydrogen bonding interactions kn-keyword=Hydrogen bonding interactions en-keyword=Cyclopentane-1,3-dione kn-keyword=Cyclopentane-1,3-dione en-keyword=Molecular docking kn-keyword=Molecular docking END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=3 article-no= start-page=e70044 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A Simple Method for RNA-Seq of Manually Isolated Chromatophores in Oryzias Fishes en-subtitle= kn-subtitle= en-abstract= kn-abstract=RNA sequencing (RNA-seq) has become an essential tool for analyzing gene expression and exploring cell type?specific transcriptomes. However, sample preparation and quality control remain challenging, as current approaches typically rely on dissecting tissues containing mixed cell populations or using flow cytometry to isolate fluorescently labeled cells. Here we present a simple and reliable method for RNA-seq of chromatophores (pigment cells) by manually isolating cells based on their natural pigmentation. We analyzed four chromatophore types?melanophores, xanthophores, iridophores, and leucophores?in medaka (Oryzias latipes). Remarkably, as few as 100 cells per type yielded reasonably high-quality transcriptomes sufficient to identify differentially expressed genes (DEGs). Furthermore, this method was successfully applied to a non-model medaka species, O. woworae, which shares the same four chromatophore types. Our approach enables efficient, low-cost, and cross-species transcriptome analysis of chromatophores without requiring transgenic markers or flow cytometry. en-copyright= kn-copyright= en-aut-name=GodaMakoto en-aut-sei=Goda en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MiyagiAsuka en-aut-sei=Miyagi en-aut-mei=Asuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SugiwakaKeisuke en-aut-sei=Sugiwaka en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WatanabeMasakatsu en-aut-sei=Watanabe en-aut-mei=Masakatsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=Bessho]UeharaManabu en-aut-sei=Bessho]Uehara en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=HibiMasahiko en-aut-sei=Hibi en-aut-mei=Masahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ToyodaAtsushi en-aut-sei=Toyoda en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TanakaRieko en-aut-sei=Tanaka en-aut-mei=Rieko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MasengiKawilarang W. A. en-aut-sei=Masengi en-aut-mei=Kawilarang W. A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamahiraKazunori en-aut-sei=Yamahira en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=AnsaiSatoshi en-aut-sei=Ansai en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=HashimotoHisashi en-aut-sei=Hashimoto en-aut-mei=Hisashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Institute of Photonics Medicine, Hamamatsu University School of Medicine kn-affil= affil-num=2 en-affil=Institute of Photonics Medicine, Hamamatsu University School of Medicine kn-affil= affil-num=3 en-affil=Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University kn-affil= affil-num=4 en-affil=Cellular and Structural Physiology Institute (CeSPI) and Graduate School of Pharmaceutical Sciences, Nagoya University kn-affil= affil-num=5 en-affil=Frontier Research Institute for Interdisciplinary Science, Tohoku University kn-affil= affil-num=6 en-affil=Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University kn-affil= affil-num=7 en-affil=Comparative Genomics Laboratory, National Institute of Genetics kn-affil= affil-num=8 en-affil=World Medaka Aquarium, Nagoya Higashiyama Zoo and Botanical Gardens kn-affil= affil-num=9 en-affil=Faculty of Fisheries and Marine Science, Sam Ratulangi University kn-affil= affil-num=10 en-affil=Tropical Biosphere Research Center, University of the Ryukyus kn-affil= affil-num=11 en-affil=Ushimado Marine Institute, Okayama University kn-affil= affil-num=12 en-affil=Department of Biological Science, Division of Natural Science, Graduate School of Science, Nagoya University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽR‘åŠw’n‹…‰ÈŠwŒ¤‹†•ñ “Še‹K’èi–ñŠ¼j en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=33 end-page=44 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Large-scale rainfall characteristics at the heavy rainfall event around the western Japan during 5?7 July 2018 kn-title=2018”N7ŒŽ5“ú?7“ú‚̼“ú–{‹‰J‚É‚¨‚¯‚éLˆæ~…“Á« en-subtitle= kn-subtitle= en-abstract= kn-abstract=@Large-scale rainfall characteristics at the heavy rainfall event around the western Japan for 5?7 July 2018 were analyzed with use of the 10-mimute precipitation data at the surface meteorological observation stations of the Japan Meteorological Agency, and so on. In this case, the area with 3 days total precipitation of near or more than 300 mm was distributed widely from northern Kyushu to Shiga and Fukui Prefectures. As in the many heavy rainfall events around Kyushu District in the mature stage of the Baiu season, contribution of the intense rainfall with more than 4 mm/10-minute (24 mm/h) attained about one third of the areal mean total precipitation. However, it is noted that the "not so intense rain" with less than 2 mm/10-minute (12 mm/h) also contributed to about one third of the huge total precipitation in the wide area. In short, this case could be characterized by the mixture of the western Japan type heavy rainfall event and the eastern Japan type one. en-copyright= kn-copyright= en-aut-name=KATOKuranoshin en-aut-sei=KATO en-aut-mei=Kuranoshin kn-aut-name=‰Á“¡“àåUi kn-aut-sei=‰Á“¡ kn-aut-mei=“àåUi aut-affil-num=1 ORCID= en-aut-name=MATSUMOTOKengo en-aut-sei=MATSUMOTO en-aut-mei=Kengo kn-aut-name=¼–{Œ’Œá kn-aut-sei=¼–{ kn-aut-mei=Œ’Œá aut-affil-num=2 ORCID= en-aut-name=OTANIKazuo en-aut-sei=OTANI en-aut-mei=Kazuo kn-aut-name=‘å’J˜a’j kn-aut-sei=‘å’J kn-aut-mei=˜a’j aut-affil-num=3 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæi—‰Èj affil-num=2 en-affil=Okayama Gakugeikan High School kn-affil=‰ªŽRŠwŒ|ŠÙ‚“™ŠwZ affil-num=3 en-affil=TV Setouchi Broadcasting Co., LTD. kn-affil=ƒeƒŒƒr‚¹‚Æ‚¤‚¿(Š”) en-keyword=western Japan heavy rainfall in July 2018 kn-keyword=western Japan heavy rainfall in July 2018 en-keyword=10-minute precipitation data kn-keyword=10-minute precipitation data en-keyword=east-west difference of the Baiu precipitation kn-keyword=east-west difference of the Baiu precipitation END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=21 end-page=31 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A trial of lesson practice at the university on the variety of heavy rainfall characteristics based on the 10-minute precipitation data toward promoting the meteorological disaster prevention literacy kn-title=10•ªŠÔ~…—Ê‚©‚ç‘å‰J‚Ì“Á’¥‚Ì‘½—l«‚𑨂¦‚é‘åŠw‚Å‚ÌŽö‹Æ‚ÌŽŽ‚Ýi–hЋCÛƒŠƒeƒ‰ƒV[ˆç¬‚ÖŒü‚¯‚Äj en-subtitle= kn-subtitle= en-abstract= kn-abstract=@In the disaster prevention education on the heavy rainfall around Japan, it is also important to promote the meteorological literacy on the seasonal and regional differences of their rainfall characteristics such as the convective rain or stratiform rain, together with their total amount of precipitation and their occurrence frequency. As the first step toward the above purpose, the present study made a lesson practice for the university students by utilizing the 10-minute precipitation data for the four heavy rainfall events, in which the types of the heavy rainfall (although all the cases examined in the lesson are relating to the deep convective clouds) are rather different from each other, such as the differences of the rainfall intensity at the peak time, short-period variation of the rainfall intensity and the persistency of the rainfall including the "not so intense rainfall". The reports by the students seem to perceive the different features among these events briefly, but the students' attention to how long the intense rainfall with short-period variation or "not so intense rainfall" lasted was not so sufficient. en-copyright= kn-copyright= en-aut-name=KATOKuranoshin en-aut-sei=KATO en-aut-mei=Kuranoshin kn-aut-name=‰Á“¡“àåUi kn-aut-sei=‰Á“¡ kn-aut-mei=“àåUi aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæi—‰Èj en-keyword=disaster prevention education kn-keyword=disaster prevention education en-keyword=variety of the heavy rainfall characteristics kn-keyword=variety of the heavy rainfall characteristics en-keyword=meteorological disaster prevention literacy kn-keyword=meteorological disaster prevention literacy en-keyword=use of the 10-minute precipitation data kn-keyword=use of the 10-minute precipitation data END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=9 end-page=19 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Petrological study of Sue ware from the Sabukaze kiln site, Okayama Prefecture kn-title=Š¦•—ŒÃ—qÕŒQ{ŒbŠí‚ÌŠâΊw“IŒ¤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=@The Sabukaze kiln site, a representative ancient tunnel-kiln site in the Kibi region, worked during the Asuka period (from early 7th century to early 8th century) to produce Sue ware including jars, cups, coffins, and ornamental tiles. To determine the provenance of the materials used for the Sue ware, we carried out petrological analyses of 13 Sue sherds, including optical microscopy, X-ray diffractometry, X-ray fluorescence spectroscopy, Raman spectroscopy, and electron-probe analysis. In spite of the difference of production time, all the Sue sherds show close similarities in modal proportion of mineral inclusions with dominant quartz and feldspar, and minor volcanic glass, in chemical compositions of feldspar and interstitial matrix, and in whole-sherd chemical composition. These similarities suggest that the paste materials of the Sabukaze Sue ware were commonly derived from weathered rhyolitic rocks and obtained from the same or neighboring mining site(s) located near the kiln site. en-copyright= kn-copyright= en-aut-name=ANAMITaiji en-aut-sei=ANAMI en-aut-mei=Taiji kn-aut-name=ˆ¢“쑾Žm kn-aut-sei=ˆ¢“ì kn-aut-mei=‘¾Žm aut-affil-num=1 ORCID= en-aut-name=NOZAKAToshio en-aut-sei=NOZAKA en-aut-mei=Toshio kn-aut-name=–ìâr•v kn-aut-sei=–ìâ kn-aut-mei=r•v aut-affil-num=2 ORCID= en-aut-name=KIMURAOsamu en-aut-sei=KIMURA en-aut-mei=Osamu kn-aut-name=–Ø‘º— kn-aut-sei=–Ø‘º kn-aut-mei=— aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Earth Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil=Department of Earth Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŠwˆæ affil-num=3 en-affil=Department of Archaeology, Osaka University kn-affil=‘åã‘åŠwlŒÃŠwŒ¤‹†Žº en-keyword=Sabukaze kiln site kn-keyword=Sabukaze kiln site en-keyword=Sue ware kn-keyword=Sue ware en-keyword=provenance kn-keyword=provenance en-keyword=petrology kn-keyword=petrology END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Microtremor exploration in Kojima Bay area, Okayama Plain kn-title=‰ªŽR•½–쎙“‡˜pŠÝ•”‚Å‚Ì”÷“®ƒAƒŒƒC’T¸ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@This report describes microtremor array observations conducted at two sites for deep exploration and three sites for shallow exploration around Kojima Bay area in the southern Okayama Plain. Based on these records, the ground velocity structures were estimated. The results yielded solutions indicating the depth of the top of the seismic base layer (equivalent to 3 km/s layer) ranges from 140 to 300 m, while the depth of the top of the engineering basement layer (equivalent to 0.6 km/s layer) is approximately about 13?14 m. The shallow exploration results also suggested the possible presence of an inversion layer. These estimated velocity structure models provided a reasonable explanation for the observed phase velocities. en-copyright= kn-copyright= en-aut-name=YAMADANobuyuki en-aut-sei=YAMADA en-aut-mei=Nobuyuki kn-aut-name=ŽR“cL”V kn-aut-sei=ŽR“c kn-aut-mei=L”V aut-affil-num=1 ORCID= en-aut-name=TAKENAKAHiroshi en-aut-sei=TAKENAKA en-aut-mei=Hiroshi kn-aut-name=’|’†”ŽŽm kn-aut-sei=’|’† kn-aut-mei=”ŽŽm aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Science and Technology, Kochi University kn-affil=‚’m‘åŠw—HŠw•”’n‹…ŠÂ‹«–hЊw‰È affil-num=2 en-affil=Department of Earth Sciences, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŠÂ‹«¶–½Ž©‘R‰ÈŠwŠwˆæ en-keyword=Okayama Plain kn-keyword=Okayama Plain en-keyword=Kojima Bay kn-keyword=Kojima Bay en-keyword=Microtremor array exploration kn-keyword=Microtremor array exploration en-keyword=S-wave velocity structure model kn-keyword=S-wave velocity structure model END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰œ•t en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=(59) end-page=(74) dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Cen Shenfs Guozhou Period: His Mental State and Poetic Expression kn-title=?BŠú‚Ì›¨ŽQ‚ɂ‚¢‚Ä \\ S‹«‚ÆŽ“I•\Œ» \\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KUROSEKanako en-aut-sei=KUROSE en-aut-mei=Kanako kn-aut-name=•£‰Á“ߎq kn-aut-sei=•£ kn-aut-mei=‰Á“ߎq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=(39) end-page=(57) dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A List of and Introduction to Takato Family Documents from Kamogata Village, Asakuchi District, Bicchu Province kn-title=”õ’†‘óŒûŒSŠ›•û‘º‚ŒË‰Æ•¶‘–Ú˜^EŽj—¿Ð‰î en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MASATSUGUKanako en-aut-sei=MASATSUGU en-aut-mei=Kanako kn-aut-name=­ŽŸ‰Á“ÞŽq kn-aut-sei=­ŽŸ kn-aut-mei=‰Á“ÞŽq aut-affil-num=1 ORCID= en-aut-name=HONDAYoshiho en-aut-sei=HONDA en-aut-mei=Yoshiho kn-aut-name=–{‘½‰À•ä kn-aut-sei=–{‘½ kn-aut-mei=‰À•ä aut-affil-num=2 ORCID= en-aut-name=HIGASHINOMasanobu en-aut-sei=HIGASHINO en-aut-mei=Masanobu kn-aut-name=“Œ–ì«L kn-aut-sei=“Œ–ì kn-aut-mei=«L aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=(21) end-page=(38) dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Ten-nyoi Heavenly Maidensj with Wings, Part 14: Feathered Robes on Taisho and Early Showa Stages kn-title=u—L—ƒ‚Ì“V—}v\Žll \ ‘å³Eº˜a‰Šú‚Ì•‘‘ä‚̉Hˆß \ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TATSUNOYuko en-aut-sei=TATSUNO en-aut-mei=Yuko kn-aut-name=—´–ì—LŽq kn-aut-sei=—´–ì kn-aut-mei=—LŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=(1) end-page=(20) dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Annotations and Translations of "Lunyu Jizhu"i9jiPart 2j kn-title=w˜_ŒêW’x–ó’iŽq㥑æ‹ã@i“ñjj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SUNLuyi en-aut-sei=SUN en-aut-mei=Luyi kn-aut-name=‘·˜HˆÕ kn-aut-sei=‘· kn-aut-mei=˜HˆÕ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹¤’Ê‹³ˆçEƒOƒ[ƒoƒ‹—̈æ END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=175 end-page=193 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Career Transitions of Lower-Ranking Officials in the Northern Dynasties after the Late Taihe Period of the Northern Wei: An Analysis Based on Epitaphs kn-title=•æŽ‚©‚猩‚½–ké°‘¾˜aŒã—߈Ȍã‚Ì–k’©‰ºˆÊŠ¯‚Ì‘J“] en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SUNQIAN en-aut-sei=SUN en-aut-mei=QIAN kn-aut-name=‘·˜è kn-aut-sei=‘· kn-aut-mei=˜è aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=155 end-page=174 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Does Environmental Spending Reduce Firm Risk? Evidence from Japanese Companies kn-title=ŠÂ‹«Žxo‚ÍŠé‹ÆƒŠƒXƒN‚ðŒyŒ¸‚·‚é‚Ì‚©H“ú–{Šé‹Æ‚ÌŽÀØ•ªÍ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@This study examines how environmental conservation costs (ECC) affects firm risk, using changes in leverage ratios and earnings volatility as stand-ins for risk. This study evaluates the direct impact of ECC and its relationship to profitability (ROA) using panel data of Japanese companies from 2010 to 2022 and Pooled OLS regression models. The results demonstrate the risk-mitigating function of sustainability investments by showing that, although independent ECC have little direct significance, their interaction with firm profitability dramatically lowers earnings volatility and leverage instability. These findings underscore the economic value of environmental strategies, suggesting that incorporating profitability considerations into sustainability practices enhances operational stability and reduces risk exposure. To help policymakers, investors, and corporate managers strike a balance between sustainability and financial performance, this study contributes to the growing body of research on the relationship between the environment and finance. en-copyright= kn-copyright= en-aut-name=NAZIRYUSRA en-aut-sei=NAZIR en-aut-mei=YUSRA kn-aut-name=ƒiƒW[ƒ‹ƒ†ƒXƒ‰ kn-aut-sei=ƒiƒW[ƒ‹ kn-aut-mei=ƒ†ƒXƒ‰ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È en-keyword=Environmental Accounting kn-keyword=Environmental Accounting en-keyword=Environmental Conservation Costs kn-keyword=Environmental Conservation Costs en-keyword=Firm Risk kn-keyword=Firm Risk en-keyword=Earnings Volatility kn-keyword=Earnings Volatility en-keyword=ESG kn-keyword=ESG en-keyword=and Risk Management Leverage Ratio kn-keyword=and Risk Management Leverage Ratio en-keyword=Sustainability kn-keyword=Sustainability en-keyword=Panel Data kn-keyword=Panel Data en-keyword=Japanese Companies kn-keyword=Japanese Companies END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=121 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on Procedural Protection of Debtors in Creditor Subrogation Litigation in China kn-title=’†‘‚ÌÂŒ ŽÒ‘ãˆÊ‘iׂɂ¨‚¯‚é–±ŽÒ‚̎葱•Ûá‚ÉŠÖ‚·‚éˆêlŽ@ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WANGYANLING en-aut-sei=WANG en-aut-mei=YANLING kn-aut-name=‰¤‰? kn-aut-sei=‰¤ kn-aut-mei=‰? aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=101 end-page=120 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Relationships between Gender Role, Ambivalent Sexism and Vocational Motivation kn-title=«–ðŠ„‚Æ—¼–ʉ¿’l“I«·•ÊŽå‹`‚É‚¨‚¯‚éA‹Æ“®‹@‚Æ‚ÌŠÖ˜A en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HAPPOSuzuha en-aut-sei=HAPPO en-aut-mei=Suzuha kn-aut-name=”ª•û—Á—t kn-aut-sei=”ª•û kn-aut-mei=—Á—t aut-affil-num=1 ORCID= en-aut-name=SUMIOKAKyoko en-aut-sei=SUMIOKA en-aut-mei=Kyoko kn-aut-name=Z‰ª‹±Žq kn-aut-sei=Z‰ª kn-aut-mei=‹±Žq aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=85 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Economic Value Generated by Innovations in Photographic Technology kn-title=ŽÊ^‹Zp‚̃Cƒmƒx[ƒVƒ‡ƒ“‚ª‘no‚·‚éŒoω¿’l en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MIYAZAKISatoru en-aut-sei=MIYAZAKI en-aut-mei=Satoru kn-aut-name=‹{èŒå kn-aut-sei=‹{è kn-aut-mei=Œå aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=65 end-page=84 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Rice Planting Customs with Songs of The Hiroshima Domain Seen in g‘ŒSŽuŒä•ÒWƒj•t‰º’²‚בo‚µ’ h: An Approach to Issues Concerning the Distribution and the Variety of ?taue kn-title=u‘ŒSŽuŒä•ÒWƒj•t‰º’²‚בo‚µ’ v‚É‚Ý‚éL“‡”˂̗̉w“cA \ ‘å“cA‚Ì•ª•z‚ÆŽí—ނɑ΂·‚éˆê‚‚̃Aƒvƒ[ƒ` \ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TAKANOHiroshi en-aut-sei=TAKANO en-aut-mei=Hiroshi kn-aut-name=ûü–ìG kn-aut-sei=ûü–ì kn-aut-mei=G aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=47 end-page=63 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Psychological changes in Japanese students who experienced interruption of their study abroad due to the COVID-19 pandemic: Analysis of the process of reinterpretation using TEM diagrams kn-title=ƒRƒƒi‰Ð‚ÅŒ»’n—¯Šw’†’f‘ÌŒ±‚ð‚µ‚½“ú–{lŠw¶‚É‚¨‚¯‚éS—“I•Ï—e \ TEM }‚ð—p‚¢‚½‘ÌŒ±‚̂Ƃ炦’¼‚µ‰ß’ö‚Ì•ªÍ \ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SAKOKoyuri en-aut-sei=SAKO en-aut-mei=Koyuri kn-aut-name=”—‚±‚ä‚è kn-aut-sei=”— kn-aut-mei=‚±‚ä‚è aut-affil-num=1 ORCID= en-aut-name=TANAKATomoko en-aut-sei=TANAKA en-aut-mei=Tomoko kn-aut-name=“c’†‹¤Žq kn-aut-sei=“c’† kn-aut-mei=‹¤Žq aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=31 end-page=46 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Current Status and Challenges in Reproductive Health and Rights in South Australia:Insights from Adelaide kn-title=“ìƒI[ƒXƒgƒ‰ƒŠƒABiƒAƒfƒŒ[ƒhj‚̃Šƒvƒƒ_ƒNƒeƒBƒuEƒwƒ‹ƒX•ƒ‰ƒCƒc‚ð‚ß‚®‚錻ó‚Ɖۑè en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SAITOKeisuke en-aut-sei=SAITO en-aut-mei=Keisuke kn-aut-name=âV“¡Œ\‰î kn-aut-sei=âV“¡ kn-aut-mei=Œ\‰î aut-affil-num=1 ORCID= en-aut-name=SUGANOSetsuko en-aut-sei=SUGANO en-aut-mei=Setsuko kn-aut-name=›–ìÛŽq kn-aut-sei=›–ì kn-aut-mei=ÛŽq aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil= kn-affil=“Œ‹ž‰ÈŠw‘åŠwŽÐ‰ï˜AŒgEDE&I–{•” END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=21 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Local Political Representation in Japan: An Attribute Analysis of Okayama Prefecture and Its Municipal Councilors kn-title=“ú–{‚Ì’n•û‹cˆõ‚É‚¨‚¯‚é‘ã•\«‚ÌŒŸ“¢F‰ªŽRŒ§’n•û‹cˆõƒf[ƒ^‚Ì•ªÍ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=IWABUCHIYasushi en-aut-sei=IWABUCHI en-aut-mei=Yasushi kn-aut-name=Šâ•£‘× kn-aut-sei=Šâ•£ kn-aut-mei=‘× aut-affil-num=1 ORCID= en-aut-name=KoebelMichel en-aut-sei=Koebel en-aut-mei=Michel kn-aut-name=ƒNƒxƒ‹ƒ~ƒVƒFƒ‹ kn-aut-sei=ƒNƒxƒ‹ kn-aut-mei=ƒ~ƒVƒFƒ‹ aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŒ¤‹†ƒ}ƒlƒWƒƒ“ƒg—̈æ affil-num=2 en-affil= kn-affil=ƒXƒgƒ‰ƒXƒu[ƒ‹‘åŠw END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page=1 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Student Perceptions of Group Work in Multicultural Collaborative Learning : A Case Study in an Area Studies Class Using GIS Software kn-title=‘½•¶‰»‹¤C‚Ì‚½‚߂̃Oƒ‹[ƒvƒ[ƒN‚©‚çŠw¶‚͉½‚ðŠ´‚¶‚½‚Ì‚©H \ GIS ƒ\ƒtƒg‚ðŽg—p‚µ‚½’nˆæŒ¤‹†Žö‹Æ‚©‚ç‚̈êlŽ@ \ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=INAMORITakao en-aut-sei=INAMORI en-aut-mei=Takao kn-aut-name=ˆîXŠx‰› kn-aut-sei=ˆîX kn-aut-mei=Šx‰› aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹¤’Ê‹³ˆçEƒOƒ[ƒoƒ‹—̈æ END start-ver=1.4 cd-journal=joma no-vol=61 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260316 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‰ªŽRŽsŒüêE•Z‹u—˂̈âÕ‘ª—Ê’²¸ŠT—v•ñ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Œõ–{‡ kn-aut-sei=Œõ–{ kn-aut-mei=‡ aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=쌎 kn-aut-sei=쌎 kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=â–ì•É“l kn-aut-sei=â–ì kn-aut-mei=•É“l aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@ŽÐ‰ï•¶‰»‰ÈŠwŠwˆæ affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=143 cd-vols= no-issue= article-no= start-page=108168 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202602 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Biallelic CAG repeat expansion in the ATXN2 gene presenting with parkinsonism and spasticity en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OsakadaYosuke en-aut-sei=Osakada en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsuokaChika en-aut-sei=Matsuoka en-aut-mei=Chika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakanoYumiko en-aut-sei=Nakano en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TairaYuki en-aut-sei=Taira en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YunokiTaijun en-aut-sei=Yunoki en-aut-mei=Taijun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=FukuiYusuke en-aut-sei=Fukui en-aut-mei=Yusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MoriharaRyuta en-aut-sei=Morihara en-aut-mei=Ryuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakemotoMami en-aut-sei=Takemoto en-aut-mei=Mami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KawaharaYuko en-aut-sei=Kawahara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KutokuYumiko en-aut-sei=Kutoku en-aut-mei=Yumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TakakiManabu en-aut-sei=Takaki en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YokotaOsamu en-aut-sei=Yokota en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=IshiuraHiroyuki en-aut-sei=Ishiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Neurology, Okayama Saiseikai General Hospital kn-affil= affil-num=10 en-affil=Department of Neurology, Kawasaki Medical School kn-affil= affil-num=11 en-affil=Department of Neuropsychiatry, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Neuropsychiatry, Okayama University Faculty of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=13 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=14 en-affil=Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=SCA2 kn-keyword=SCA2 en-keyword=ATXN2 kn-keyword=ATXN2 en-keyword=Biallelic kn-keyword=Biallelic en-keyword=Parkinsonism kn-keyword=Parkinsonism END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=1 article-no= start-page=23 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260205 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Band-selective plasmonic polaron in thermoelectric semimetal Ta2PdSe6 with ultra-high power factor en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report the electronic structure of the thermoelectric semimetal Ta2PdSe6 with a large thermoelectric power factor and giant Peltier conductivity by means of angle-resolved photoemission spectroscopy (ARPES). The ARPES spectra reveal the coexistence of a sharp hole band with a light electron mass and a broad electron band with a relatively heavy electron mass, which originate from different quasi-one-dimensional (Q1D) chains in Ta2PdSe6. Moreover, the electron band around the Brillouin-zone (BZ) boundary shows a replica structure with respect to the energy originating from plasmonic polarons due to electron-plasmon interactions. The different scattering effects and interactions in each atomic chain lead to asymmetric transport lifetimes of carriers: a large Seebeck coefficient can be realized even in a semimetal. Our findings pave the way for exploring the thermoelectric materials in previously overlooked semimetals and provide a new platform for low-temperature thermoelectric physics, which has been challenging with semiconductors. en-copyright= kn-copyright= en-aut-name=OotsukiDaiki en-aut-sei=Ootsuki en-aut-mei=Daiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakanoAkitoshi en-aut-sei=Nakano en-aut-mei=Akitoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MaruokaUrara en-aut-sei=Maruoka en-aut-mei=Urara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HasegawaTakumi en-aut-sei=Hasegawa en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AritaMasashi en-aut-sei=Arita en-aut-mei=Masashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KitamuraMiho en-aut-sei=Kitamura en-aut-mei=Miho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=HoribaKoji en-aut-sei=Horiba en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YoshidaTeppei en-aut-sei=Yoshida en-aut-mei=Teppei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TerasakiIchiro en-aut-sei=Terasaki en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=2 en-affil=Present address: Department of Applied Physics, Nagoya University kn-affil= affil-num=3 en-affil=Present address: Department of Applied Physics, Nagoya University kn-affil= affil-num=4 en-affil=Graduate School of Advanced Science and Engineering, Hiroshima University kn-affil= affil-num=5 en-affil=Research Institute for Synchrotron Radiation Science, Hiroshima University kn-affil= affil-num=6 en-affil=Present address: NanoTerasu Center, National Institutes for Quantum Science and Technology (QST) kn-affil= affil-num=7 en-affil=Present address: NanoTerasu Center, National Institutes for Quantum Science and Technology (QST) kn-affil= affil-num=8 en-affil=Graduate School of Human and Environmental Studies, Kyoto University kn-affil= affil-num=9 en-affil=Present address: Department of Applied Physics, Nagoya University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=3 article-no= start-page=e72040 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Overload on Imiquimod]Induced Psoriasis Model Mice: A Basic Experimental Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background and Aim: Psoriasis is a skin disorder complicated by arthritis and enthesitis. The cytokines interleukin (IL)-17, IL-23, and tumor necrosis factor (TNF)-ƒ¿ are reportedly key effectors of psoriasis. Additionally, gamma delta (ƒÁƒÂ) T cells exacerbate inflammation by producing inflammatory cytokines such as IL-17 and TNF-ƒ¿. However, details regarding the mechanisms linking pathogenesis and mechanical stress remain unclear. This study aimed to investigate the effect of strenuous exercise on the pathology of psoriasis using mouse models of imiquimod (IMQ)-induced psoriasis.
Methods: Twenty mice were randomly assigned to four groups: IMQ???TRED? (control), IMQ???TRED+ (treadmill running mice), IMQ?+?TRED? group (IMQ treated mice), and IMQ?+?TRED+ group (IMQ treated and treadmill running mice). The tissue sections from back skin and thymus were immunostained with antibodies against IL-17, IL-23, and ƒÁƒÂ T cells. Shoulder sections were stained using hematoxylin and eosin, and Toluidine Blue and Picrosirius Red. Additionally, the shoulder tissue sections were immunostained with antibodies against TNF-ƒ¿ and matrix metalloproteinase (MMP)-13. Serum cytokine level was measured to evaluate systemic inflammation.
Results: Strenuous exercise exacerbated pathological changes associated with psoriasis, including increased ƒÁƒÂ T cell infiltration and upregulated IL-17 and IL-23 expression in the skin, as well as enhanced ƒÁƒÂ T cell development and IL-17 expression in the thymus. Although strenuous exercise did not further worsen the modified PASI scores, histological and immunological markers of inflammation were significantly enhanced. Serum levels of TNF-ƒ¿ and IL-17 were significantly elevated in IMQ-induced psoriasis model mice. Moreover, pathological changes induced by strenuous exercise were observed in the enthesis, including angiogenesis and upregulated expression of TNF-ƒ¿ and MMP-13.
Conclusion: This study revealed that strenuous exercise exacerbates pathological changes in IMQ-induced psoriasis model mice. en-copyright= kn-copyright= en-aut-name=FurutaniTomoki en-aut-sei=Furutani en-aut-mei=Tomoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SaitoTaichi en-aut-sei=Saito en-aut-mei=Taichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IkedaAsahi en-aut-sei=Ikeda en-aut-mei=Asahi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MashimaKenta en-aut-sei=Mashima en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YukihiroNatsumi en-aut-sei=Yukihiro en-aut-mei=Natsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KusakabeSatoki en-aut-sei=Kusakabe en-aut-mei=Satoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakamichiRyo en-aut-sei=Nakamichi en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YoshidaAki en-aut-sei=Yoshida en-aut-mei=Aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=NishidaKeiichiro en-aut-sei=Nishida en-aut-mei=Keiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Orthopaedic Surgery, Section of Medicine, Division of Medicine, Dentistry, and Pharmaceutical Sciences, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Okayama University Medical School Faculty of Medicine kn-affil= affil-num=4 en-affil=Okayama University Medical School Faculty of Medicine kn-affil= affil-num=5 en-affil=Okayama University Medical School Faculty of Medicine kn-affil= affil-num=6 en-affil=Okayama University Medical School Faculty of Medicine Okayama Japan kn-affil= affil-num=7 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=8 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Locomotive Pain Center, Okayama University Hospital kn-affil= affil-num=10 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= en-keyword=enthesis kn-keyword=enthesis en-keyword=psoriasis kn-keyword=psoriasis en-keyword=strenuous exercise kn-keyword=strenuous exercise END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=1 article-no= start-page=e70168 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Mechanosensitive Ion Channel PIEZO1 Suppresses BMP2-Induced Ossification of the Annulus Fibrosus Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=Objective: Major cause of low-back pain is intervertebral disc degeneration (IVDD), with mechanical stress playing a crucial role in its progression. A mechanosensitive ion channel, PIEZO1, is involved in various musculoskeletal tissues, but its role in the annulus fibrosus (AF) remains unclear. This study aimed to elucidate the function of PIEZO1 in AF cells under mechanical stimulation.
Methods: Primary rat AF cells were subjected to cyclic tensile strain (CTS) at low (2%) and high (12%) strain levels to investigate strain-dependent effects on osteogenic gene expression. We evaluated the effects of Piezo1, Piezo2, and Trpv4 knockdown by RNA interference to identify the upstream mechanotransducer. Furthermore, PIEZO1 was activated using the agonist Yoda1, followed by RNA-sequencing analysis and evaluation of its effects on BMP2-induced osteogenesis in rat AF cells. We also examined the effects of Yoda1 in primary human AF cells.
Results: Low-strain CTS significantly suppressed osteogenic marker expression, which was not observed with high strain. Piezo1 knockdown reversed this suppression, whereas Piezo2 and Trpv4 had no effect. Piezo1 activation by Yoda1 produced similar anti-osteogenic effects in both rat and human AF cells. RNA sequencing revealed the enrichment of ossification and calcineurin signaling pathways in rat cells. Furthermore, Piezo1 activation inhibited BMP2-induced osteogenesis and nuclear translocation of p-Smad1/5/9.
Conclusions: Piezo1 maintains AF cell homeostasis under mechanical stress by suppressing osteogenic changes via calcineurin-mediated inhibition of BMP signaling, which may represent a novel therapeutic target for IVDD. en-copyright= kn-copyright= en-aut-name=ShitozawaHisakazu en-aut-sei=Shitozawa en-aut-mei=Hisakazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=NakamichiRyo en-aut-sei=Nakamichi en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YoshidaAki en-aut-sei=Yoshida en-aut-mei=Aki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UedaMasataka en-aut-sei=Ueda en-aut-mei=Masataka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SaitoTaichi en-aut-sei=Saito en-aut-mei=Taichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UotaniKoji en-aut-sei=Uotani en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OdaYoshiaki en-aut-sei=Oda en-aut-mei=Yoshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=TakatoriRyo en-aut-sei=Takatori en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamashitaKazutaka en-aut-sei=Yamashita en-aut-mei=Kazutaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OzakiToshifumi en-aut-sei=Ozaki en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Orthopaedic Surgery, Okayama University Graduate School Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Orthopaedic Surgery, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Orthopaedic Surgery, Okayama University Hospital kn-affil= affil-num=7 en-affil=Department of Orthopaedic Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=9 en-affil=Department of Orthopaedic Surgery, Science of Functional Recovery and Reconstruction, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=10 en-affil=Department of Orthopaedic Surgery, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=annulus fibrosus kn-keyword=annulus fibrosus en-keyword=calcification kn-keyword=calcification en-keyword=ossification kn-keyword=ossification en-keyword=PIEZO1 kn-keyword=PIEZO1 END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page=111 end-page=126 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Die Agrarstruktur in Sachsen im 19. Jahrhunderti5j kn-title=19¢‹IƒUƒNƒZƒ“‚Ì“y’n§“xi‚Tj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MatsuoNobushige en-aut-sei=Matsuo en-aut-mei=Nobushige kn-aut-name=¼”ö“W¬ kn-aut-sei=¼”ö kn-aut-mei=“W¬ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw–¼—_‹³Žö END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page=41 end-page=91 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Re-theorizing Consumer Behavior in the Age of Human?AI Coexistence: The AIBCBM Framework kn-title=AI ‹¤¶Žž‘ã‚É‚¨‚¯‚éÁ”ïŽÒs“®‚ÌÄ—˜_‰»\AIBCBM ƒtƒŒ[ƒ€ƒ[ƒN\ en-subtitle= kn-subtitle= en-abstract=@This study aims to construct and present the AI-Based Consumer Behavior ModeliAIBCBMj as a theoretical framework that systematically explains the tripartite interaction among companies, consumers, and AI in environments where AI intervenes from the pre-decision stage. First, it identifies the critical theoretical limitations of existing consumer behavior models, which fail to adequately address contemporary phenomena such as algorithmic exposure, recursive learning loops, and AI-mediated social influence. Building upon this, the study presents the AIBCBM iAI-Based Consumer Behavior Modelj, which conceptualizes consumer behavior in the era of AI symbiosis as a tripartite cyclical structure involvingg business?AI?consumer.h
@In constructing the model, rather than oversimplifying complex reality, theoretical clarity and analytical tractability are ensured by separating it into a tripartite co-evolutionary structure model iFigure 2j, a behavioral process model illustrating the dynamics of behavior generationiTable 3j, a conceptual structure modeliFigure 3j, and a behavioral typology modeliFigure 4j. The theoretical contributions of this study are summarized in five points:
i1j redefining System 1 as a behavioral generation mechanism;
i2j redefining decision-making agents and power structures;
i3j theoretically modeling nonlinear, high-speed feedback loops in consumer behavior;
i4j Theoretical redefinition of non-consumption and JOMO as strategic behaviors grounded in well-being and human agency.
i5j reconceptualizing consumer behavior from a "decision-making model" to a "behavior generation model."
@Moreover, the duality highlighted in this study?where algorithm-driven utility enhancement and autonomy impairment can coexist?provides a new normative and theoretical evaluation framework for marketing strategies and policy design in the AI era. AIBCBM functions as a theoretical platform that integrates these perspectives, serving as a foundation for future theoretical development and empirical validation. In particular, AIBCBM is distinctive in positioning JOMO and non-consumption not as passive withdrawal from algorithmic environments, but as strategic behaviors through which consumers intentionally calibrate their distance from AI-constructed choice architectures to preserve human agency, well-being, and human-likeness.
@Finally, the proposed model serves as a theoretical coordinate framework that systematically connects firm-side AI design, algorithmic dynamics, and consumer agency and well-being, thereby bridging empirical inquiry and normative design in the age of AI co-existence. kn-abstract=@–{Œ¤‹†‚ÍCAI‚ªˆÓŽvŒˆ’è‚Ì‘O’iŠK‚©‚ç‰î“ü‚·‚éŠÂ‹«‚É‚¨‚¢‚ÄCŠé‹ÆEÁ”ïŽÒEAI‚ÌŽOŽÒ‘ŠŒÝì—p‚ð‘ÌŒn“I‚Éà–¾‚·‚é—˜_˜g‘g‚Ý‚Æ‚µ‚ÄCArtificial Intelligence-Based Consumer Behavior ModeliAIBCBMj‚ð\’z‚µC’ñŽ¦‚·‚邱‚Æ‚ð–Ú“I‚Æ‚·‚éB‚Ü‚¸CŠù‘¶‚ÌÁ”ïŽÒs“®ƒ‚ƒfƒ‹‚ªCƒAƒ‹ƒSƒŠƒYƒ€˜IoCÄ‹A“IŠwKƒ‹[ƒvCAI”}‰îŒ^ŽÐ‰ï“I‰e‹¿iAlgorithmic Social Influencej‚Æ‚¢‚Á‚½Œ»‘ã“IŒ»Û‚ð\•ª‚Ɉµ‚¦‚È‚¢‚Æ‚¢‚¤Œˆ’è“I‚È—˜_“IŒÀŠE‚𖾂炩‚É‚·‚éB‚»‚Ì‚¤‚¦‚ÅCAI‹¤¶Žž‘ã‚É‚¨‚¯‚éÁ”ïŽÒs“®‚ðCuŠé‹Æ|AI|Á”ïŽÒv‚ÌŽOŽÒzŠÂ\‘¢‚Æ‚µ‚Ä‘¨‚¦‚éAIBCBM‚ð’ñŽ¦‚·‚éB
@ƒ‚ƒfƒ‹\’z‚ÉÛ‚µ‚Ä‚ÍC•¡ŽG‚ÈŒ»ŽÀ‚ð‰ß“x‚É’Pƒ‰»‚·‚é‚Ì‚Å‚Í‚È‚­CŽOŽÒ‹¤i‰»\‘¢ƒ‚ƒfƒ‹i}‚QjCs“®¶¬‚Ì“®‘Ô‚ðŽ¦‚·s“®ƒvƒƒZƒXƒ‚ƒfƒ‹i•\‚RjCŠT”O\‘¢ƒ‚ƒfƒ‹i}‚RjCs“®—ÞŒ^ƒ‚ƒfƒ‹i}‚Sj‚É•ª—£‚·‚邱‚Æ‚ÅC—˜_“I–¾—Ä«‚Æ•ªÍ‰Â”\«‚ðŠm•Û‚µ‚½B–{Œ¤‹†‚Ì—˜_“IvŒ£‚ÍC‡@System ‚P‚ðs“®¶¬ƒƒJƒjƒYƒ€‚Æ‚µ‚ÄÄ’è‹`‚µ‚½“_C‡AˆÓŽvŒˆ’èŽå‘Ì‚ÆŒ —Í\‘¢‚ðÄ’è‹`‚µ‚½“_C‡BÁ”ïŽÒs“®‚É‚¨‚¯‚é”ñüŒ`E‚‘¬ƒtƒB[ƒhƒoƒbƒNƒ‹[ƒv‚ð—˜_‰»‚µ‚½“_C‡C”ñÁ”ï‚âJOMO‚ðCK•Ÿ‚ÆŽå‘Ì«‚ɪ‚´‚µ‚½í—ª“Is“®‚Æ‚µ‚Ä—˜_“I‚ÉÄ’è‹`‚µ‚½“_C‡DÁ”ïŽÒs“®‚ðuˆÓŽvŒˆ’胂ƒfƒ‹v‚©‚çus“®¶¬ƒ‚ƒfƒ‹v‚Ö—˜_“I‚É“]Š·‚µ‚½“_‚ÉW–ñ‚³‚ê‚éB‚³‚ç‚ÉC–{Œ¤‹†‚ª’ñŽ¦‚·‚éCƒAƒ‹ƒSƒŠƒYƒ€‚É‚æ‚éŒø—p‚ÌŒüã‚ÆŽ©—¥«‚̚ʑ¹‚ª•¹‘¶‚µ‚¤‚é‚Æ‚¢‚¤“ñ–Ê«‚ÍCAIŽž‘ã‚É‚¨‚¯‚éƒ}[ƒPƒeƒBƒ“ƒOí—ª‚¨‚æ‚Ñ­ôÝŒv‚ɑ΂µ‚ÄC‹K”Í“I‚©‚—˜_“I‚ÈV‚½‚È•]‰¿Ž²‚ð’ñ‹Ÿ‚·‚éBAIBCBM‚ÍC‚±‚ê‚ç‚ÌŽ‹À‚𓇂·‚é—˜_“Iƒvƒ‰ƒbƒgƒtƒH[ƒ€‚Æ‚µ‚ÄC¡Œã‚ÌŽÀØŒ¤‹†‚ÉŒü‚¯‚½Šî”Õ‚Æ‚µ‚Ä‹@”\‚·‚éB‚Æ‚è‚킯C AIBCBM‚ÍCJOMO‚â”ñÁ”ïs“®‚ðCƒAƒ‹ƒSƒŠƒYƒ€ŠÂ‹«‚©‚ç‚ÌŽó“®“I“P‘Þ‚Å‚Í‚È‚­CAI‚É‚æ‚Á‚Ä\’z‚³‚ꂽ‘I‘ðŠÂ‹«‚Æ‚Ì‹——£‚ðˆÓ}“I‚É’²®‚µClŠÔ‚炵‚³ilŠÔ‚Æ‚µ‚Ä‚ÌŽå‘Ì«‚âƒEƒFƒ‹ƒr[ƒCƒ“ƒOj‚ð•ÛŽ‚·‚邽‚ß‚Ìí—ª“Is“®‚Æ‚µ‚Ĉʒu‚¯‚é“_‚É“ÆŽ©«‚ð—L‚·‚éB‚³‚ç‚É–{ƒ‚ƒfƒ‹‚ÍCAIÝŒviŠé‹Æ‘¤jEƒAƒ‹ƒSƒŠƒYƒ€“®‘ÔiAI‘¤jEŽå‘Ì«‚ƃEƒFƒ‹ƒr[ƒCƒ“ƒOiWell-beingjiÁ”ïŽÒ‘¤j‚𓯈ê˜g‘g‚Ý‚ÅÚ‘±‚·‚邱‚Æ‚ÅCAI‹¤¶Žž‘ã‚ÌŽÀØŒ¤‹†‚Æ‹K”ÍÝŒv‚ð‰Ë‹´‚·‚é—˜_“IÀ•WŽ²‚ðŠm—§‚·‚éB en-copyright= kn-copyright= en-aut-name=ShazadigulSawut en-aut-sei=Shazadigul en-aut-mei=Sawut kn-aut-name=‰ÄH’ñŒÃ?¹Œá’ñ kn-aut-sei=‰ÄH’ñŒÃ? kn-aut-mei=¹Œá’ñ aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Humanities and Social Sciences, Okayama University kn-affil= en-keyword=s“®¶¬ƒ‚ƒfƒ‹ (Behavior Generation Model) kn-keyword=s“®¶¬ƒ‚ƒfƒ‹ (Behavior Generation Model) en-keyword=lŠÔ|AI‚Ì‹¤“¯Žå‘Ì« (Human-AI Co-agency/Shared Agency) kn-keyword=lŠÔ|AI‚Ì‹¤“¯Žå‘Ì« (Human-AI Co-agency/Shared Agency) en-keyword=ƒAƒ‹ƒSƒŠƒYƒ€“I‘I‘ðŠÂ‹« (Algorithmic Choice Architecture) kn-keyword=ƒAƒ‹ƒSƒŠƒYƒ€“I‘I‘ðŠÂ‹« (Algorithmic Choice Architecture) en-keyword=”ñÁ”ï^ˆÓ}“I‚È”ñŽg—p (Non-consumption/Intentional Non-use) kn-keyword=”ñÁ”ï^ˆÓ}“I‚È”ñŽg—p (Non-consumption/Intentional Non-use) en-keyword=Ä‹A“IŠwKƒ‹[ƒv (Recursive Learning Loops) kn-keyword=Ä‹A“IŠwKƒ‹[ƒv (Recursive Learning Loops) END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page=11 end-page=40 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Network Analysis of Interregional Information Exchange: A Study in the Takahashi River Basin Area kn-title=’nˆæŠÔ‚Å‚Ìî•ñŒð—¬‚ÉŠÖ‚·‚éƒlƒbƒgƒ[ƒN•ªÍF‚—Àì—¬ˆæŒ—‚Å‚Ì’²¸‚É‚æ‚é en-subtitle= kn-subtitle= en-abstract=@This paper conducted network analysis focusing on information exchange among participating entities in the "Takahashi River Basin Economic Growth Strategy Council," operating within Okayama Prefecture's "Takahashi River Basin Core City Area." The Takahashi River Basin Collaborative Core City Areai Takahashi River Basin Areajis a collaborative core city area encompassing ten municipalities located around the Takahashi River in Okayama Prefecture: Niimi City, Takahashi City, Soja City, Hayashima Town, Kurashiki City, Yakage Town, Ibara City, Asakuchi City, Satosho Town, and Kasaoka City. For the network analysis within the Takahashi River Basin Area, projects implemented within the area were classified into eight categories. A questionnaire survey was conducted regarding information exchange among participating entities for each project. Network metrics included calculating centrality indicesi degree centrality and betweenness centralityj for each project, along with density, transitivity, and reciprocity. By project type, tourism projects exhibited the densest network structure for information exchange. From a network perspective, tourism projects can be considered the most actively pursued initiative within the Takahashi River Basin area. Furthermore, across all projects, centrality indicators for specific administrative bodies and regional economic organizations, such as chambers of commerce and industry, generally showed high values. This clearly indicates their function as hubs for information exchange and as entities concentrating or dispersing information within the network. Based on the results of network analysis, two recommendations for future regional development in the Takahashi River Basin were proposed from a network perspective. The first is to aim for dense networks across all businesses by sharing the roles of information exchange hubs and information concentration/distribution entities among the entities involved, depending on the business. The second is to aim for a dense network overall by eliminating entities that are not participating at all in the Takahashi River Basin's information exchange network. kn-abstract=@–{e‚Å‚ÍC‰ªŽRŒ§‚Ìu‚—Àì—¬ˆæ˜AŒg’†•“sŽsŒ—v‚Å2014”N‚©‚çŠJ³‚ê‚Ä‚¢‚éu‚—Àì—¬ˆæŒoϬ’·í—ª‰ï‹cv‚É‚¨‚¯‚éŽQ‰ÁŽå‘ÌŠÔ‚Ìî•ñŒð—¬‚ɂ‚¢‚Ẵlƒbƒgƒ[ƒN•ªÍ‚ðs‚Á‚½B‚—Àì—¬ˆæ˜AŒg’†•“sŽsŒ—i‚—Àì—¬ˆæŒ—j‚Æ‚ÍC‰ªŽRŒ§‚—ÀìŽü•Ó‚Ɉʒu‚·‚錻݂ÌVŒ©ŽsC‚—ÀŽsC‘ŽÐŽsC‘“‡’¬C‘q•~ŽsC–îŠ|’¬CˆäŒ´ŽsCóŒûŽsC—¢¯’¬CŠ}‰ªŽs‚Ì10Ž©Ž¡‘Ì‚ªŽQ‰Á‚µ‚Ä‚¢‚é˜AŒg’†•“sŽsŒ—‚Å‚ ‚éB‚—Àì—¬ˆæŒ—‚É‚¨‚¯‚éƒlƒbƒgƒ[ƒN•ªÍ‚ÉÛ‚µ‚Ä‚ÍC“¯Œ—ˆæ“à‚Å“WŠJ‚³‚ê‚Ä‚¢‚鎖‹Æ‚ð‚W‚‚ɕª—Þ‚µC‚»‚ꂼ‚ê‚ÌŽ–‹Æ‚ÉŠÖ‚·‚éŽQ‰ÁŽå‘ÌŠÔ‚Ìî•ñŒð—¬‚ɂ‚¢‚ăAƒ“ƒP[ƒg’²¸‚ðs‚Á‚½Bƒlƒbƒgƒ[ƒNŽw•W‚ɂ‚¢‚Ä‚ÍŽ–‹Æ‚²‚Æ‚ÉŽŸ”’†S«‚Æ”}‰î’†S«‚Ì’†S«Žw•W‚ðC‚Ü‚½Ž–‹Æ•Ê‚É–§“xC„ˆÚ«C‘ŠŒÝ«‚ðŽZo‚µ‚½BŽ–‹Æ•Ê‚É‚Ý‚é‚ÆCŠÏŒõŽ–‹Æ‚ɂ‚¢‚Ä‚Ìî•ñŒð—¬‚ªÅ‚à–§‚ȃlƒbƒgƒ[ƒN\‘¢‚ð‚µ‚Ä‚¨‚èCƒlƒbƒgƒ[ƒN‚ÌŽ‹“_‚Å‚ÍŠÏŒõŽ–‹Æ‚ª‚—Àì—¬ˆæŒ—“à‚Åłਗ͓I‚És‚í‚ê‚Ä‚¢‚鎖‹Æ‚Æ‚¢‚¦‚éB‚Ü‚½‘SŽ–‹Æ‚É‚¨‚¢‚Ä“Á’è‚Ìs­Žå‘Ì‚â¤H‰ï‹cŠ‚ð‚Í‚¶‚ß‚Æ‚·‚é’nˆæŒoÏ’c‘Ì“™‚Ì’†S«Žw•W‚ª‘S‘Ì“I‚É‘å‚«‚È’l‚ð‚Æ‚Á‚Ä‚¨‚èCƒlƒbƒgƒ[ƒN‚É‚¨‚¢‚Äî•ñŒð—¬‚̃nƒu‚âî•ñ‚ÌW’†E•ªŽUŽå‘Ì‚Æ‚µ‚Ä‹@”\‚µ‚Ä‚¢‚邱‚Æ‚ª–¾‚ç‚©‚É‚È‚Á‚½B•ªÍŒ‹‰Ê‚𓥂܂¦Cƒlƒbƒgƒ[ƒN‚ÌŽ‹“_‚©‚ç‚—Àì—¬ˆæŒ—‚Ì¡“x‚Ì’nˆæU‹»‚ɂ‚¢‚Ä‚Q“_’ñŒ¾‚µ‚½B‚P‚‚͎–‹Æ‚É‚æ‚Á‚Äî•ñŒð—¬‚̃nƒu‚âî•ñ‚ÌW’†E•ªŽUŽå‘Ì‚ðŽå‘ÌŠÔ‚Å•ª’S‚·‚邱‚Æ‚É‚æ‚Á‚ÄC‚·‚ׂĂ̎–‹Æ‚Å–§‚ȃlƒbƒgƒ[ƒN‚ð’z‚­‚±‚Æ‚ð–ÚŽw‚·‚±‚Æ‚Å‚ ‚éB‚à‚¤‚P‚‚͂—Àì—¬ˆæŒ—‚Ìî•ñŒð—¬ƒlƒbƒgƒ[ƒN‚É‘S‚­ŽQ‰Á‚µ‚Ä‚¢‚È‚¢Žå‘Ì‚ð‚È‚­‚·‚±‚Æ‚ÅC‘S‘Ì“I‚É–§‚ȃlƒbƒgƒ[ƒN‚ð–ÚŽw‚·‚±‚Æ‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=NakamuraRyohei en-aut-sei=Nakamura en-aut-mei=Ryohei kn-aut-name=’†‘º—Ç•½ kn-aut-sei=’†‘º kn-aut-mei=—Ç•½ aut-affil-num=1 ORCID= en-aut-name=YokotaNatsumi en-aut-sei=Yokota en-aut-mei=Natsumi kn-aut-name=‰¡“c‰ÄŽÀ kn-aut-sei=‰¡“c kn-aut-mei=‰ÄŽÀ aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw affil-num=2 en-affil= kn-affil=‰ºŠÖŽs–ðŠ END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page=1 end-page=10 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 1998 Amendment to the Foreign Exchange and Foreign Trade Control Act and the Classification of Income from Gains and Losses on Foreign Currency Transactions: How Did the Amendment of 1998 Affect Income Classification? kn-title=1998”N‚ÌŠO‘ˆ×‘Ö‹y‚ÑŠO‘–fˆÕŠÇ—–@‰ü³‚Æ ŠO‘’ʉ݂Ì÷“n‚É‚æ‚鑹‰v‚ÌŠ“¾‹æ•ª \1998”N‚Ì–@‰ü³‚ÍŠ“¾‹æ•ª‚ɂǂ̂悤‚ȉe‹¿‚ð—^‚¦‚½‚Ì‚©\ en-subtitle= kn-subtitle= en-abstract=@The 1998 amendment to the Foreign Exchange and Foreign Trade Control Acti subsequently renamed the Foreign Exchange and Foreign Trade Actj liberalized foreign exchange transactions, which had previously been restricted in principle to authorized foreign exchange banks. This amendment allowed all companies and individuals to freely conduct such transactions.
@This paper first examines the basis for the tax authorities' view that "gains or losses from foreign currency transfers constitute miscellaneous income," drawing from government witness testimony in the Diet and the Tokyo District Court judgement of March 9, 2023. Then it concludes that the 1998 legal amendment, by enabling anyone to freely conduct foreign currency transactions both internationally and domestically, transformed foreign currency into a means of payment functioning as a measure of value. Consequently, it became impossible to conceptualize foreign currency as an asset subject to appreciation or depreciation, leading to the reclassification of income from its transfer from capital gains to miscellaneous income. kn-abstract=@1998”N‚ÌŠO‘ˆ×‘Ö‹y‚ÑŠO‘–fˆÕŠÇ—–@‚̉ü³iˆÈ~CŠO‘ˆ×‘Ö‹y‚ÑŠO‘–fˆÕ–@‚ɉü–¼j‚É‚æ‚èC‚»‚ê‚Ü‚ÅŠO‘ˆ×‘ÖŒö”F‹âs‚ÉŒ´‘¥‚Æ‚µ‚ÄŒÀ‚ç‚ê‚Ä‚¢‚½ŠO‘ˆ×‘ÖŽæˆø‚ªC‚ ‚ç‚ä‚éŠé‹Æ‹y‚ÑŒÂl‚ɉð•ú‚³‚êCŽ©—R‚És‚¤‚±‚Æ‚ª‚Å‚«‚é‚悤‚É‚È‚Á‚½B
@–{e‚ÍC‚Ü‚¸‰ÛÅ“–‹Ç‚ÌuŠO‘’ʉ݂Ì÷“n‚É‚æ‚鑹‰v‚ÍŽGŠ“¾‚ÉŠY“–‚·‚év‚Æ‚ÌŒ©‰ð‚Ì”»’fª‹’‚ðC‘‰ï‚É‚¨‚¯‚é­•{ŽQll“š•Ù‹y‚Ñ“Œ‹ž’nٗߘa‚T”N‚RŒŽ‚X“ú”»Œˆ‚©‚ç“ǂ݉ð‚«C‚»‚Ì‚¤‚¦‚ÅC1998”N‚Ì–@‰ü³‚É‚æ‚èŠO‘’ʉݎæˆø‚ª‘ΊO‹y‚Ñ‘“à‚É‚¨‚¢‚ĉ½l‚àŽ©—R‚És‚¤‚±‚Æ‚ª‚Å‚«‚é‚悤‚É‚È‚Á‚½‚±‚Æ‚©‚çCŠO‘’ʉ݂͎x•¥Žè’i‚Æ‚µ‚ÄŒ¾‚í‚Ή¿’l‚ÌŽÚ“x‚Æ‚µ‚Ä‹@”\‚·‚é‚悤‚É‚È‚èCŽ‘ŽY‚Ì’lオ‚èC’l‰º‚ª‚è‚ðŠÏ”O‚·‚邱‚Æ‚ª‚Å‚«‚È‚­‚È‚Á‚½Œ‹‰Ê‚Æ‚µ‚ÄC‚»‚Ì÷“n‚É‚æ‚銓¾‹æ•ª‚ª÷“nŠ“¾‚©‚çŽGŠ“¾‚ւƕω»‚µ‚½‚Æ‚ÌŒ‹˜_‚𓱂­‚à‚Ì‚Å‚ ‚éB en-copyright= kn-copyright= en-aut-name=NakagawaYoshiyuki en-aut-sei=Nakagawa en-aut-mei=Yoshiyuki kn-aut-name=’†ì‹g”V kn-aut-sei=’†ì kn-aut-mei=‹g”V aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=3 article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260318 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=24 cd-vols= no-issue=1 article-no= start-page=146 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that cleave a plethora of substrates, including components of the extracellular matrix and cell-surface-associated proteins, as well as intracellular targets. MMPs have also been found in extracellular vesicles (EVs), such as exosomes. MMP-3 promotes tumor growth, epithelial-to-mesenchymal transition, genome instability, migration, invasion, and metastasis of cancer cells, and nuclear MMP-3 controls gene transcription. Intranuclear proteolysis by MMPs may significantly alter cancer progression. However, the nuclear substrates of MMP-3 have not been well investigated. In this study, we performed proteomic analyses to identify the nuclear substrates and EV proteins regulated by MMP-3. While rabidly metastatic colon cancer (LuM1) three-dimensionally cultured tumoroids secreted EVs containing 30 protein types, including Lamin A (LMNA), MMP-3, fibronectin (FN1), HSPA8 (Hsc70), ƒÀ-actin (ACTB), and vimentin (VIM), CRISPR/Cas9-based knockout of MMP-3 reduced the secretion of these proteins in EVs. Notably, EV-bound cleaved Lamin secretion was confirmed by immunoelectron microscopy. Also, MMP-3 formed proteolytic dimers via its hemopexin-like repeat domains in nuclei. Many nuclear MMP-3-binding proteins, including Lamin A/C, histones, topoisomerases, and hnRNPs, were screened by co-immunoprecipitation followed by proteomics. Proteolytic MMP-3 overexpression generated a C-terminal 30-kDa fragment of Lamin A, whose cleavage site was defined via structural analysis. MMP-3 digestion of Lamin A induced nuclear deformity (atypia) required for cell migration in confined space. The cleaved Lamin A and MMP-3 were transported with autophagosomes (LC3B+), nucleophagosomes, and amphisomes (CD63?+?LC3B+) and co-secreted with EVs. Proteolytic MMP-3 also induced nuclear speckles of Lamin A, suggesting their roles in transcription and splicing. Clinical analysis revealed that high expressions of MMP3 and LMNA were significantly seen in head and neck squamous cell carcinoma (HNSC) than in the other 16 cancer types, and predicted poor prognosis of patients suffering from HNSC, pancreatic, rectum and lung adenocarcinomas at specific stages. Immunohistochemistry revealed that nuclear MMP-3 and cleaved Lamin were significantly higher expressed in stage IV metastatic HNSC cases than in stage I non-metastatic cases. Taken together, MMP3-cleavage of Lamin A induces nuclear deformity, nucleophagy, and their autophagic co-secretion with EVs in metastatic cancer. Also, high expression of MMP-3 and secretion of Lamin A can predict poor prognosis in multiple cancer types at specific stages. en-copyright= kn-copyright= en-aut-name=EguchiTakanori en-aut-sei=Eguchi en-aut-mei=Takanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TahaEman A. en-aut-sei=Taha en-aut-mei=Eman A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakanoKeisuke en-aut-sei=Nakano en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TiwariVikas en-aut-sei=Tiwari en-aut-mei=Vikas kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakebeKatsuki en-aut-sei=Takebe en-aut-mei=Katsuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=InoueTomohiro en-aut-sei=Inoue en-aut-mei=Tomohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=XingLizi en-aut-sei=Xing en-aut-mei=Lizi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SogawaChiharu en-aut-sei=Sogawa en-aut-mei=Chiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OkamotoKuniaki en-aut-sei=Okamoto en-aut-mei=Kuniaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=CalderwoodStuart K. en-aut-sei=Calderwood en-aut-mei=Stuart K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Biochemistry, Faculty of Science, Ain Shams University kn-affil= affil-num=3 en-affil=Department of Oral Pathology and Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Council of Scientific & Industrial Research-Indian Institute of Toxicological Research kn-affil= affil-num=5 en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Food and Health Sciences, Faculty of Environmental Studies, Hiroshima Institute of Technology kn-affil= affil-num=9 en-affil=Department of Dental Pharmacology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=10 en-affil=Division of Molecular and Cellular Biology, Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School kn-affil= en-keyword=Lamin A (LMNA) kn-keyword=Lamin A (LMNA) en-keyword=Matrix metalloprotease (MMP) kn-keyword=Matrix metalloprotease (MMP) en-keyword=Proteolysis kn-keyword=Proteolysis en-keyword=Extracellular vesicle (EV) kn-keyword=Extracellular vesicle (EV) en-keyword=Exosome kn-keyword=Exosome en-keyword=Autophagy kn-keyword=Autophagy en-keyword=Amphisome kn-keyword=Amphisome en-keyword=Proteome kn-keyword=Proteome en-keyword=Nuclear deformity kn-keyword=Nuclear deformity en-keyword=Migration kn-keyword=Migration en-keyword=Metastatic cancer kn-keyword=Metastatic cancer en-keyword=Head and neck squamous cell carcinoma kn-keyword=Head and neck squamous cell carcinoma en-keyword=Colorectal cancer kn-keyword=Colorectal cancer END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=5 article-no= start-page=2339 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Concentration-Dependent Synergistic Interfacial Interactions Between Multifunctional Acrylate and Silane Coupling Agents in an Organic?Inorganic Nanohybrid Material en-subtitle= kn-subtitle= en-abstract= kn-abstract=Synergistic effects of a multifunctional acrylate and a long-chain silane coupling agent were investigated in an organic?inorganic nanohybrid material. We tested the bond strength of nanohybrid composites treated with experimental primers containing silane coupling agents?3-methacryloxypropyl trimethoxysilane (ƒÁ-MPTS) or 8-methacryloxyoctyl trimethoxysilane (8-MOTS)?with or without multifunctional acrylates?trimethylolpropane triacrylate (A-TMPT) or dipentaerythritol hexaacrylate (A-DPH). Shear bond strength was evaluated after 24 h of water storage at 37 ‹C. Untreated control and silane-only groups exhibited low shear bond strengths (e.g., control: 2.4 } 2.0 MPa) and failed exclusively at the adhesive interface. While addition of A-TMPT did not significantly improve bond strength, addition of A-DPH produced significantly higher shear bond strengths. Highest strength was achieved with 30% 8-MOTS and A-DPH (22.4 } 6.1 MPa), followed by 20% ƒÁ-MPTS and A-DPH (19.0 } 7.0 MPa), and A-DPH groups produced cohesive failures. Regardless of the silane used (ƒÁ-MPTS or 8-MOTS), incorporating A-DPH in the primer consistently yielded superior bond strengths, indicating a promising strategy for improved adhesion for such nanohybrid systems. These findings provide new insights into optimizing resin?filler interfacial interactions and may contribute to the development of restorative materials with improved long-term clinical durability. en-copyright= kn-copyright= en-aut-name=MaruoYukinori en-aut-sei=Maruo en-aut-mei=Yukinori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshiharaKumiko en-aut-sei=Yoshihara en-aut-mei=Kumiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IrieMasao en-aut-sei=Irie en-aut-mei=Masao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NagaokaNoriyuki en-aut-sei=Nagaoka en-aut-mei=Noriyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KodamaNaoki en-aut-sei=Kodama en-aut-mei=Naoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YoshizaneMai en-aut-sei=Yoshizane en-aut-mei=Mai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=AkiyamaKentaro en-aut-sei=Akiyama en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Prosthodontics, Okayama University kn-affil= affil-num=2 en-affil=Health Research Institute, National Institute of Advanced Industrial Science and Technology kn-affil= affil-num=3 en-affil=Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Advanced Research Center for Oral and Craniofacial Sciences, Dental School, Okayama University kn-affil= affil-num=5 en-affil=Department of Prosthodontics, Okayama University kn-affil= affil-num=6 en-affil=Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Occlusal and Oral Functional Rehabilitation, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=silane coupling kn-keyword=silane coupling en-keyword=multifunctional acrylate kn-keyword=multifunctional acrylate en-keyword=bond strength kn-keyword=bond strength en-keyword=resin kn-keyword=resin END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue=3 article-no= start-page=117345 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202607 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Investigation of the cefazolin inoculum effect in blood culture-isolated methicillin-susceptible Staphylococcus aureus strains: A Japanese multicenter study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Cefazolin inoculum effect (CInE) is a microbiological phenomenon where the MIC of cefazolin against methicillin-susceptible Staphylococcus aureus (MSSA) strains increases with higher bacterial volumes.
Method: We retrospectively investigated the prevalence and characteristics of the CInE among MSSA strains isolated from blood cultures at three Japanese hospitals. The collected isolates were screened for blaZ using PCR, and the cefazolin minimum inhibitory concentration (MIC) for the blaZ-positive MSSA isolates was measured at standard and high inoculum volumes. CInE-positive MSSA strains were defined as those with a cefazolin MIC ?16 ƒÊg/mL at 107 CFU/mL and ?8 ƒÊg/mL at 105 CFU/mL. In these blaZ-positive strains, we performed blaZ typing and tested a modified nitrocefin-based rapid examination to detect the CInE.
Results: We collected 329 MSSA strains isolated from blood cultures. Of these, 96 (29.2%) were positive for the blaZ gene, with the following genotypes: type A (15, 15.6%), type B (3, 3.1%), type C (77, 80.2%), type D (0, 0.0%), and non-type (1, 1.0%). Among 96 blaZ-positive MSSA isolates, 11 exhibited the CInE, all of which harbored blaZ type A. The rapid nitrocefin test detected CInE positivity with high sensitivity (100%), specificity (94.1%), and diagnostic accuracy (94.8%).
Conclusion: This study highlighted the low prevalence of CInE-presenting MSSA isolates in Japan. When the cefazolin MIC is ?1 ƒÊg/mL or the penicillin G MIC is ?0.25 ƒÊg/mL, the rapid nitrocefin test may be useful for considering the CInE in patients with high bacterial volume MSSA infections. en-copyright= kn-copyright= en-aut-name=FukushimaShinnosuke en-aut-sei=Fukushima en-aut-mei=Shinnosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TsujiShuma en-aut-sei=Tsuji en-aut-mei=Shuma kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=GotohKazuyoshi en-aut-sei=Gotoh en-aut-mei=Kazuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=IioKoji en-aut-sei=Iio en-aut-mei=Koji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OgawaSakura en-aut-sei=Ogawa en-aut-mei=Sakura kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KoyanagiNorihito en-aut-sei=Koyanagi en-aut-mei=Norihito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=ItoYuji en-aut-sei=Ito en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KoganemaruHiroshi en-aut-sei=Koganemaru en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YoshidaAtsushi en-aut-sei=Yoshida en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Medical Laboratory Science, Okayama University Graduate School of Health Sciences kn-affil= affil-num=3 en-affil=Department of Medical Laboratory Science, Okayama University Graduate School of Health Sciences kn-affil= affil-num=4 en-affil=Microbiology Division, Clinical Laboratory, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Department of Clinical Laboratory, Chutoen General Medical Center kn-affil= affil-num=7 en-affil=Department of General Internal Medicine, Chutoen General Medical Center kn-affil= affil-num=8 en-affil=Department of Infectious Diseases, Tokyo Metropolitan Institute for Geriatrics and Gerontology kn-affil= affil-num=9 en-affil=Department of Infectious Diseases, Tokyo Metropolitan Institute for Geriatrics and Gerontology kn-affil= affil-num=10 en-affil=Department of Infectious Diseases, Okayama University Hospital kn-affil= en-keyword=blaZ kn-keyword=blaZ en-keyword=Cefazolin inoculum effect kn-keyword=Cefazolin inoculum effect en-keyword=Methicillin-susceptible Staphylococcus aureus kn-keyword=Methicillin-susceptible Staphylococcus aureus en-keyword=Nitrocefin rapid test kn-keyword=Nitrocefin rapid test en-keyword=ƒÀ-lactamase kn-keyword=ƒÀ-lactamase END start-ver=1.4 cd-journal=joma no-vol=69 cd-vols= no-issue=5 article-no= start-page=5944 end-page=5955 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260218 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Discovery of Thermal Sensitizers That Inhibit Heat-Induced SAFB Granule Formation en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hyperthermia is a minimally invasive cancer treatment based on heat stress-induced apoptosis. Its therapeutic efficacy, however, is often limited by tumor heterogeneity and acquired thermotolerance. Therefore, combination strategies involving hyperthermia and chemotherapy have been developed to enhance the therapeutic efficacy. Previously, we showed that SB366791 enhanced heat-induced apoptosis by inhibiting heat stress-induced scaffold attachment factor B (SAFB) granule formation, although its proapoptotic activity was insufficient. Therefore, we screened to identify novel compounds that enhance heat-induced apoptosis by suppressing SAFB granule formation. We identified four hit compounds that inhibited SAFB granule formation, all exhibiting thermal enhancement ratios > 1.0„Ÿthat significantly enhanced heat-induced apoptosis efficiency. Additionally, the tumor volume in mice treated with a combination of Z19024498 and hyperthermia was significantly smaller than that in mice treated with hyperthermia or Z19024498. These results indicate that the identified compounds, specifically Z19024498, have potential as thermal sensitizers for hyperthermia therapy. en-copyright= kn-copyright= en-aut-name=FurutaniYuji en-aut-sei=Furutani en-aut-mei=Yuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimasakiNatsuki en-aut-sei=Shimasaki en-aut-mei=Natsuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamadaRiko en-aut-sei=Yamada en-aut-mei=Riko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhtsukiTakashi en-aut-sei=Ohtsuki en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WatanabeKazunori en-aut-sei=Watanabe en-aut-mei=Kazunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=2 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=3 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=4 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=5 en-affil=Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=165 cd-vols= no-issue= article-no= start-page=105344 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202503 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Local immune response induced by intra-fin antigen injection in Japanese medaka (Oryzias latipes) is a useful model for immunological studies en-subtitle= kn-subtitle= en-abstract= kn-abstract=Teleost fishes play a pivotal role in advancing our understanding of immune system evolution because they retain the ancient characteristics of vertebrate immunity, encompassing both innate and adaptive immune systems. Among these, innate immunity plays a critical role in fish as the first line of defense, coordinating rapid responses to pathogen infections. However, the lack of fish-specific immunological methodologies has limited progress in elucidating fish immune mechanisms. To better understand how the innate immune response develops and resolves in fish, detailed observation and integrative analysis of leukocytes at multiple time points is necessary. In the present study, an intra-fin injection method for observing local immune responses in Japanese medaka (Oryzias latipes) was tested and optimized to analyze the progression of zymosan-induced innate immune responses. Zymosan-injected medaka showed a rapid immune response characterized by leukocyte recruitment and phagocytosis. Using TG(FmpxP:mCherry) transgenic medaka with mCherry fluorescence driven by myeloperoxidase (mpx) promoter, granulocyte chemotaxis towards the site of zymosan entry was successfully visualized. The rapid increase in tumor necrosis factor ƒ¿ (tnfa), interleukin-1ƒÀ (il1b), interleukin-6 (il6), and CXC motif chemokine ligand 8 (cxcl8) expressions in zymosan-injected anal fins provided a molecular basis for the visualized tissue-specific cellular response. Our study underscores the dynamic orchestration of immune components during the innate immune response in Japanese medaka and highlights their potential as a promising model for immunological research. en-copyright= kn-copyright= en-aut-name=RyuTsukasa en-aut-sei=Ryu en-aut-mei=Tsukasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshinoMizuki en-aut-sei=Yoshino en-aut-mei=Mizuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TseWilliam Ka Fai en-aut-sei=Tse en-aut-mei=William Ka Fai kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AnsaiSatoshi en-aut-sei=Ansai en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=IguchiTaisen en-aut-sei=Iguchi en-aut-mei=Taisen kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KumarAnu en-aut-sei=Kumar en-aut-mei=Anu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SomamotoTomonori en-aut-sei=Somamoto en-aut-mei=Tomonori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NakaoMiki en-aut-sei=Nakao en-aut-mei=Miki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OginoYukiko en-aut-sei=Ogino en-aut-mei=Yukiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Graduate School of Bioresource and Bioenvironmental Sciences, Laboratory of Marine Biochemistry, Kyushu University kn-affil= affil-num=2 en-affil=Graduate School of Bioresource and Bioenvironmental Sciences, Laboratory of Marine Biology, Kyushu University kn-affil= affil-num=3 en-affil=Graduate School of Bioresource and Bioenvironmental Sciences, Laboratory of Developmental Disorders and Toxicology, Kyushu University kn-affil= affil-num=4 en-affil=Ushimado Marine Institute, Faculty of Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Nanobioscience, Yokohama City University kn-affil= affil-num=6 en-affil=Commonwealth Scientific and Industrial Research Organisation, CSIRO Environment kn-affil= affil-num=7 en-affil=Graduate School of Bioresource and Bioenvironmental Sciences, Laboratory of Marine Biochemistry, Kyushu University kn-affil= affil-num=8 en-affil=Graduate School of Bioresource and Bioenvironmental Sciences, Laboratory of Marine Biochemistry, Kyushu University kn-affil= affil-num=9 en-affil=Center for Promotion of International Education and Research, Faculty of Agriculture, Kyushu University kn-affil= en-keyword=Chemotaxis kn-keyword=Chemotaxis en-keyword=Local immunity kn-keyword=Local immunity en-keyword=Inflammation kn-keyword=Inflammation en-keyword=Innate immunity kn-keyword=Innate immunity en-keyword=Phagocytosis kn-keyword=Phagocytosis en-keyword=Zymosan kn-keyword=Zymosan END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=3 article-no= start-page=e198959 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251223 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Collagen-binding C-type natriuretic peptide enhances chondrogenesis and osteogenesis en-subtitle= kn-subtitle= en-abstract= kn-abstract=C-type natriuretic peptide (CNP) is known to promote chondrocyte proliferation and bone formation; however, CNPfs extremely short half-life necessitates continuous intravascular administration to achieve bone-lengthening effects. Vosoritide, a CNP analog designed for resistance to neutral endopeptidase, allows for once-daily administration. Nonetheless, it distributes systemically rather than localizing to target tissues, which may result in adverse effects such as hypotension. To enhance local drug delivery and therapeutic efficacy, we developed a potentially novel synthetic protein by fusing a collagen-binding domain (CBD) to CNP, termed CBD-CNP. This fusion protein exhibited stability under heat conditions and retained the collagen-binding ability and bioactivity as CNP. CBD-CNP localized to articular cartilage in fetal murine tibiae and promoted bone elongation. Spatial transcriptomic analysis revealed that the upregulation of chondromodulin expression may contribute to its therapeutic effects. Treatment of CBD-CNP mixed with collagen powder to a fracture site of a mouse model increased bone mineral content and bone volume compared with CNP-22. Intraarticular injection of CBD-CNP to a mouse model of knee osteoarthritis suppressed subchondral bone thickening. By addressing the limitations of CNPfs rapid degeneration, CBD-CNP leverages its collagen-binding capacity to achieve targeted, sustained delivery in collagen-rich tissues, offering a promising strategy for enhancing chondrogenesis and osteogenesis. en-copyright= kn-copyright= en-aut-name=HiraiKenta en-aut-sei=Hirai en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SawamuraKenta en-aut-sei=Sawamura en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=EsakiRyusaku en-aut-sei=Esaki en-aut-mei=Ryusaku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SawadaRyusuke en-aut-sei=Sawada en-aut-mei=Ryusuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkushaYuka en-aut-sei=Okusha en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=AoyamaEriko en-aut-sei=Aoyama en-aut-mei=Eriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SaitoHiroki en-aut-sei=Saito en-aut-mei=Hiroki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=UchidaKentaro en-aut-sei=Uchida en-aut-mei=Kentaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MimaTakehiko en-aut-sei=Mima en-aut-mei=Takehiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=KubotaSatoshi en-aut-sei=Kubota en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TsukaharaHirokazu en-aut-sei=Tsukahara en-aut-mei=Hirokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=ImagamaShiro en-aut-sei=Imagama en-aut-mei=Shiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MatsushitaMasaki en-aut-sei=Matsushita en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=MatsushitaOsamu en-aut-sei=Matsushita en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=HosonoYasuyuki en-aut-sei=Hosono en-aut-mei=Yasuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine kn-affil= affil-num=3 en-affil=Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine kn-affil= affil-num=4 en-affil=Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=5 en-affil=Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=6 en-affil=Advanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School kn-affil= affil-num=7 en-affil=Department of Orthopaedic Surgery, Kitasato University School of Medicine kn-affil= affil-num=8 en-affil=Department of Orthopaedic Surgery, Kitasato University School of Medicine kn-affil= affil-num=9 en-affil=Department of Medical Technology, Faculty of Health Sciences, Ehime Prefectural University of Health Sciences kn-affil= affil-num=10 en-affil=Department of Biochemistry and Molecular DentistryBacteriology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=11 en-affil=Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=12 en-affil=Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine kn-affil= affil-num=13 en-affil=Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine kn-affil= affil-num=14 en-affil=Department of Bacteriology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= affil-num=15 en-affil=Department of Pharmacology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences kn-affil= END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=2 article-no= start-page=199 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260128 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Targeting the Gut in Sepsis: Therapeutic Potential of Medical Gases en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sepsis is a life-threatening condition characterized by a dysregulated host response to infection, often resulting in multiorgan dysfunction. Among affected systems, the gastrointestinal tract plays a central role in sepsis progression by promoting systemic inflammation through impaired barrier function, immune imbalance, and microbiome alterations. Recent research has identified selected medical gases and gasotransmitters as promising therapeutic candidates for preserving gut integrity in sepsis. In particular, hydrogen, carbon monoxide, and hydrogen sulfide exhibit antioxidative, anti-inflammatory, and cytoprotective properties. These gases act through defined molecular pathways, including activation of Nrf2, inhibition of NF-ƒÈB, and preservation of tight junction integrity, thereby supporting intestinal barrier function. In addition, they influence immune cell phenotypes and autophagy, with indirect effects on the gut microbiome. Although most supporting evidence derives from preclinical models, translational findings and emerging safety data highlight the potential of gut-targeted gas-based strategies. This review summarizes current mechanistic and translational evidence for gut-protective medical gases in sepsis and discusses their integration into future organ-specific and mechanism-based therapeutic approaches. en-copyright= kn-copyright= en-aut-name=YumotoTetsuya en-aut-sei=Yumoto en-aut-mei=Tetsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ObaraTakafumi en-aut-sei=Obara en-aut-mei=Takafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NakaoAtsunori en-aut-sei=Nakao en-aut-mei=Atsunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Emergency, Critical Care, and Disaster Medicine, Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=carbon monoxide kn-keyword=carbon monoxide en-keyword=gastrointestinal tract kn-keyword=gastrointestinal tract en-keyword=gut kn-keyword=gut en-keyword=hydrogen kn-keyword=hydrogen en-keyword=hydrogen sulfide kn-keyword=hydrogen sulfide en-keyword=sepsis kn-keyword=sepsis en-keyword=septic shock kn-keyword=septic shock END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=1 article-no= start-page=888 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=TRPV2 in muscle satellite cells is crucial for skeletal muscle remodelling en-subtitle= kn-subtitle= en-abstract= kn-abstract=Skeletal muscle remodelling relies on muscle stem cells (MuSCs) for regeneration after injury and hypertrophy in response to mechanical loading. However, the mechanisms that trigger MuSC activation and proliferation remain unclear. Transient receptor potential vanilloid 2 (TRPV2) ion channels respond to insulin-like growth factor-1 and mechanical stimuli to regulate the biological characteristics of various cells. Using a temporally inducible MuSC-specific conditional knockout (cKO) mouse, we show that TRPV2 regulates MuSC function and is essential for muscle remodelling. In cultured myofibre, MuSCs express TRPV2 and exhibit Ca2+ responses to the TRPV2 agonists 2-aminoethoxydiphenyl borate and probenecid, which are abolished upon TRPV2 deletion. TRPV2-deficient MuSCs exhibit reduced paired box 7 (Pax7) expression and impaired proliferation, suggesting TRPV2 is a factor that regulates the early stage of MuSC function. Myotube formation in MuSCs was enhanced by overexpression of TRPV2 and suppressed by TRPV2 deficiency, suggesting that TRPV2 is a factor that promotes myogenesis. Muscle-administered cardiotoxin promoted muscle regeneration and resulted in the appearance of numerous Pax7-positive MuSCs between myofibres. MuSC-specific TRPV2 cKO mice exhibit substantially impaired muscle regeneration after cardiotoxin-induced injury, drastically reducing Pax7-positive MuSCs between myofibres. In floxed mice, mechanical loading via synergist ablation induces hypertrophy and greatly increases the number of myonuclei per myofibre. In contrast, MuSC-specific TRPV2 cKO mice show no changes in myofibre thickness or nuclear number, either at baseline or after mechanical loading. Mechanical loading of floxed mice increased TRPV2+/Pax7+ double-positive MuSCs, but MuSC-specific TRPV2 cKO mice showed no change. Additionally, MuSCs exhibit Ca2+ responses to hypo-osmotic stimuli, which are suppressed by TRPV2 inhibitors and TRPV2 deletion, suggesting that MuSCs exhibit TRPV2-dependent mechanical responses. These results establish TRPV2 as a critical regulator of MuSC-mediated muscle remodelling, an important finding that may lead to therapeutic strategies for muscle repair and adaptation. en-copyright= kn-copyright= en-aut-name=ChenYanzhu en-aut-sei=Chen en-aut-mei=Yanzhu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KatanosakaKimiaki en-aut-sei=Katanosaka en-aut-mei=Kimiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ShibuyaMakoto en-aut-sei=Shibuya en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DongYubing en-aut-sei=Dong en-aut-mei=Yubing kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ZhangLidan en-aut-sei=Zhang en-aut-mei=Lidan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KanagawaMotoi en-aut-sei=Kanagawa en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=FukadaSo-ichiro en-aut-sei=Fukada en-aut-mei=So-ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NaruseKeiji en-aut-sei=Naruse en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KatanosakaYuki en-aut-sei=Katanosaka en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University kn-affil= affil-num=3 en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Laboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, The University of Osaka kn-affil= affil-num=6 en-affil=Department of Cell Biology and Molecular Medicine, Ehime University Graduate School of Medicine kn-affil= affil-num=7 en-affil=Laboratory of Stem Cell Regeneration and Adaptation, Graduate School of Pharmaceutical Sciences, The University of Osaka kn-affil= affil-num=8 en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=10 article-no= start-page=e70269 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=202510 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=D3 lymph node dissection in colon cancer patients aged 90?years and over: Is it justified? A multi]institutional retrospective study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aim: The oncological benefit of D3 lymph node dissection (D3 LND) for colon cancer in patients aged ?90?years remains unclear. This study aimed to evaluate the impact of D3 LND on outcomes in this specific, vulnerable population.
Method: This retrospective cohort study evaluated 166 patients aged ?90?years with pathological Stages II?III colon cancer undergoing non-D3 or D3 LND from a multicentre database (2011?2022). Postoperative complications, overall survival and cancer-specific survival were compared between LND groups using propensity score-weighted analyses.
Results: D3 LND group had significantly more females and laparoscopic procedures. Operation time was longer, and blood loss was lower in the D3 LND group. Postoperative complications and severe complications were significantly fewer, and postoperative hospital stay was shorter in the D3 LND group. The number of harvested lymph nodes and distal margin was significantly higher in the D3 group. While unadjusted analysis showed better overall survival with D3 LND (p? Conclusion: In nonagenarian colon cancer patients, D3 LND is safe and feasible without increasing complications, but lacks survival benefit. Careful consideration is warranted, and high-quality D2 LND must be consistently ensured when limited surgery is chosen. en-copyright= kn-copyright= en-aut-name=TeraishiFuminori en-aut-sei=Teraishi en-aut-mei=Fuminori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakanagaSatoe en-aut-sei=Takanaga en-aut-mei=Satoe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InadaRyo en-aut-sei=Inada en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=ToshimaToshiaki en-aut-sei=Toshima en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OhtaniTsuyoshi en-aut-sei=Ohtani en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YoshidaRyosuke en-aut-sei=Yoshida en-aut-mei=Ryosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ShojiRyohei en-aut-sei=Shoji en-aut-mei=Ryohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=Setouchi Colorectal Neoplasm Registration study group collaborators en-aut-sei=Setouchi Colorectal Neoplasm Registration study group collaborators en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Surgery, Kochi Health Sciences Center kn-affil= affil-num=4 en-affil=Center for Innovative Clinical Medicine, Medical Development Field, Okayama University kn-affil= affil-num=5 en-affil=Department of Surgery, Kagawa Rosai Hospital kn-affil= affil-num=6 en-affil=Department of Surgery, Saiseikai Okayama Hospital kn-affil= affil-num=7 en-affil=Department of Surgery, Okayama Rosai Hospital kn-affil= affil-num=8 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil= affil-num=9 en-affil=Department of Gastroenterological Surgery, Okayama University Hospital kn-affil= affil-num=10 en-affil= kn-affil= en-keyword=colon cancer kn-keyword=colon cancer en-keyword=lymph node dissection kn-keyword=lymph node dissection en-keyword=nonagenarian kn-keyword=nonagenarian en-keyword=postoperative complication kn-keyword=postoperative complication en-keyword=survival benefit kn-keyword=survival benefit END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Overexpression of Escherichia coli yaiX Confers Multidrug Resistance and Enhances Virulence in the Silkworm Infection Model en-subtitle= kn-subtitle= en-abstract= kn-abstract=The emergence of bacteria with both antimicrobial resistance and high virulence has become a global health concern, underscoring the urgent need to elucidate the molecular basis underlying these traits. Here, we employed the silkworm (Bombyx mori) infection model, which is suitable for high-throughput screening, together with an Escherichia coli library containing plasmid clones of all genes from strain W3110, to identify genes whose overexpression enhances virulence. We found that overexpression of the uncharacterized protein YaiX promoted bacterial proliferation in silkworms and increased host lethality. Compared with the empty-vector control, the YaiX-overexpressing strain exhibited resistance to multiple antimicrobial agents with diverse mechanisms of action, including ƒÀ-lactams, tetracyclines, fluoroquinolones, aminoglycosides, cationic surfactants, and hydrogen peroxide. Sequence analysis revealed that amino acids 18?52 of YaiX contain a transferase hexapeptide domain predicted to form a left-handed parallel ƒÀ-helix. Overexpression of YaiX mutants lacking regions outside this domain conferred ampicillin resistance, whereas deletion of the hexapeptide domain abolished this phenotype. RNA sequencing and GO enrichment analyses further indicated that YaiX overexpression altered the expression of genes encoding RNA-binding proteins and porins. These findings suggest that YaiX overexpression, through its hexapeptide domain, modulates gene expression and contributes to both multidrug resistance and enhanced virulence in E. coli. en-copyright= kn-copyright= en-aut-name=HonguKinuka en-aut-sei=Hongu en-aut-mei=Kinuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshikawaKazuya en-aut-sei=Ishikawa en-aut-mei=Kazuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KosakiTomoki en-aut-sei=Kosaki en-aut-mei=Tomoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyoshiShin]Ichi en-aut-sei=Miyoshi en-aut-mei=Shin]Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=FurutaKazuyuki en-aut-sei=Furuta en-aut-mei=Kazuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KaitoChikara en-aut-sei=Kaito en-aut-mei=Chikara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Research Center for Intestinal Health Science, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=Escherichia coli kn-keyword=Escherichia coli en-keyword=hexapeptide domain kn-keyword=hexapeptide domain en-keyword=multidrug resistance kn-keyword=multidrug resistance en-keyword=pseudogene function kn-keyword=pseudogene function en-keyword=RNA]seq kn-keyword=RNA]seq en-keyword=silkworm infection model kn-keyword=silkworm infection model en-keyword=virulence kn-keyword=virulence en-keyword=yaiX kn-keyword=yaiX END start-ver=1.4 cd-journal=joma no-vol=411 cd-vols= no-issue=1 article-no= start-page=21 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251127 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Surgical outcomes and patient selection in nonagenarians with colon cancer: a comparative multi-institutional study of laparoscopic and open approaches en-subtitle= kn-subtitle= en-abstract= kn-abstract=Purpose The appropriate surgical approach for colon cancer (CC) in nonagenarian patients remains a subject of clinical debate. This study aimed to compare the short-term outcomes of laparoscopic (Lap) versus open (Open) surgery in patients aged???90 years with resectable colon cancer.
Methods This multi-institutional retrospective cohort study included oldest-old patientswith pathological Stage II/III CC who underwent elective surgery at 15 hospitals between 2011 and 2022. Patients with rectal cancer, Stage 0/I/IV disease, or emergency surgery were excluded. To address selection bias, inverse-probability-weighted regression adjustment and stabilized inverse probability of treatment weighting (sIPTW) were applied. The primary outcome was postoperative complications; secondary outcomes included overall survival (OS).
Results Median age was 92 years in both groups. Before adjustment, the Lap group had a higher proportion of female patients (p?=?0.038) and lower ASA scores (p?=?0.01). Laparoscopic surgery was associated with a significantly longer operative time (220 vs. 171 min, p?=?0.046) but less intraoperative blood loss (10 vs. 78 mL, p? Conclusion Both laparoscopic and open surgery are feasible options for selected nonagenarians with colon cancer. Laparoscopic surgery may offer benefits in terms of reduced blood loss and shorter hospitalization, despite longer operative times. Careful patient selection considering frailty and comorbidities is essential in determining the most appropriate surgical approach. en-copyright= kn-copyright= en-aut-name=ShojiRyohei en-aut-sei=Shoji en-aut-mei=Ryohei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TeraishiFuminori en-aut-sei=Teraishi en-aut-mei=Fuminori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakanagaSatoe en-aut-sei=Takanaga en-aut-mei=Satoe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MitsuhashiToshiharu en-aut-sei=Mitsuhashi en-aut-mei=Toshiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=InadaRyo en-aut-sei=Inada en-aut-mei=Ryo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ToshimaToshiaki en-aut-sei=Toshima en-aut-mei=Toshiaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OhtaniTsuyoshi en-aut-sei=Ohtani en-aut-mei=Tsuyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YoshidaRyosuke en-aut-sei=Yoshida en-aut-mei=Ryosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HoriNaoto en-aut-sei=Hori en-aut-mei=Naoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=ShigemitsuKaoru en-aut-sei=Shigemitsu en-aut-mei=Kaoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YamamotoSumiharu en-aut-sei=Yamamoto en-aut-mei=Sumiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=KubotaTetsushi en-aut-sei=Kubota en-aut-mei=Tetsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OkanoYuka en-aut-sei=Okano en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=NobuhisaTetsuji en-aut-sei=Nobuhisa en-aut-mei=Tetsuji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TaniguchiFumitaka en-aut-sei=Taniguchi en-aut-mei=Fumitaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=IshikawaWataru en-aut-sei=Ishikawa en-aut-mei=Wataru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=MatsudaTatsuo en-aut-sei=Matsuda en-aut-mei=Tatsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=UmeokaTatsuo en-aut-sei=Umeoka en-aut-mei=Tatsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=Setouchi Colorectal Neoplasm Registration study group collaborators en-aut-sei=Setouchi Colorectal Neoplasm Registration study group collaborators en-aut-mei= kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= affil-num=1 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=3 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=4 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= affil-num=5 en-affil=Department of Surgery, Kochi Health Sciences Center kn-affil= affil-num=6 en-affil=Department of Surgery, Kagawa Rosai Hospital kn-affil= affil-num=7 en-affil=Department of Surgery, Saiseikai Okayama Hospital kn-affil= affil-num=8 en-affil=Department of Surgery, Okayama Rosai Hospital kn-affil= affil-num=9 en-affil=Department of Surgery, Tottori Municipal Hospital kn-affil= affil-num=10 en-affil=Department of Surgery, Tsuyama Chuo Hospital kn-affil= affil-num=11 en-affil=Department of Surgery, Okayama City Hospital kn-affil= affil-num=12 en-affil=Department of Surgery, Kobe Red Cross Hospital kn-affil= affil-num=13 en-affil=Department of Surgery, Onomichi City Hospital kn-affil= affil-num=14 en-affil=Department of Surgery, Himeji Red Cross Hospital kn-affil= affil-num=15 en-affil=Department of Surgery, National Hospital Organization Iwakuni Clinical Center kn-affil= affil-num=16 en-affil=Department of Surgery, Fukuyama City Hospital kn-affil= affil-num=17 en-affil=Department of Surgery, Matsuda Hospital kn-affil= affil-num=18 en-affil=Department of Surgery, Matsuyama City Hospital kn-affil= affil-num=19 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=20 en-affil= kn-affil= en-keyword=Oldest-old patients kn-keyword=Oldest-old patients en-keyword=Colon cancer kn-keyword=Colon cancer en-keyword=Laparoscopic surgery kn-keyword=Laparoscopic surgery en-keyword=Surgical outcome kn-keyword=Surgical outcome en-keyword=Overall survival kn-keyword=Overall survival END start-ver=1.4 cd-journal=joma no-vol=70 cd-vols= no-issue=3 article-no= start-page=329 end-page=336 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251224 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Prevalence and Modifiable Risk Factors of Dementia in People With Down Syndrome: Cross]Sectional Study of Japan in Collaboration With the Intellectual Diversity for Goodness Research Consortium (INDIGO]2019) en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: People with Down syndrome (DS) have a strong genetic predisposition to Alzheimer's disease (AD). However, the clinical burden and associated risk factors in diverse, non-Western populations remain less understood. This study aimed to investigate the prevalence of dementia in Japanese adults with DS and to identify modifiable clinical factors associated with dementia.
Methods: This cross-sectional multicentre study surveyed 133 adults with DS (mean age 50.1?years) residing in 45 welfare facilities across Japan in 2019. Dementia was diagnosed by a consensus panel of physicians using established criteria (DSM-5, ICD-10, DC-LD) after comprehensive assessments, including the Japanese version of the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities (DSQIID-J). Logistic regression analysis was performed to identify factors independently associated with dementia.
Results: Forty-six participants (34.6%) were diagnosed with dementia. The prevalence rose sharply with age: 0% in their 30s, 30.8% in their 40s, 31.6% in their 50s and 65.5% in their 60s. After adjusting for covariates, older age, female sex, dyslipidaemia and visual impairment were independently associated with dementia.
Conclusions: This study, the largest of its kind in Asia, confirms a high prevalence of dementia in institutionalized Japanese adults with DS. Crucially, this study is the first to identify dyslipidaemia and visual impairment as independent and potentially modifiable risk factors in this population. These findings highlight tangible targets for clinical interventions aimed at mitigating dementia risk in people with DS. en-copyright= kn-copyright= en-aut-name=TakenoshitaShintaro en-aut-sei=Takenoshita en-aut-mei=Shintaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TeradaSeishi en-aut-sei=Terada en-aut-mei=Seishi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=InoueTomokazu en-aut-sei=Inoue en-aut-mei=Tomokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KurozumiTaku en-aut-sei=Kurozumi en-aut-mei=Taku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakakiManabu en-aut-sei=Takaki en-aut-mei=Manabu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KuwanoRyozo en-aut-sei=Kuwano en-aut-mei=Ryozo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SuemitsuShigeru en-aut-sei=Suemitsu en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Neuropsychiatry, Okayama University Hospital kn-affil= affil-num=2 en-affil=Department of Neuropsychiatry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Asahigawaso Research Institute, Social Welfare Corporation Asahigawaso kn-affil= affil-num=4 en-affil=Asahigawaso Research Institute, Social Welfare Corporation Asahigawaso kn-affil= affil-num=5 en-affil=Department of Neuropsychiatry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Asahigawaso Research Institute, Social Welfare Corporation Asahigawaso kn-affil= affil-num=7 en-affil=Asahigawaso Research Institute, Social Welfare Corporation Asahigawaso kn-affil= END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue= article-no= start-page=RP99825 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250618 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Stimulatory and inhibitory G-protein signaling relays drive cAMP accumulation for timely metamorphosis in the chordate Ciona en-subtitle= kn-subtitle= en-abstract= kn-abstract=Larvae of the ascidian Ciona initiate metamorphosis tens of minutes after adhesion to a substratum via their adhesive organ. The gap between adhesion and metamorphosis initiation is suggested to ensure the rigidity of adhesion, allowing Ciona to maintain settlement after losing locomotive activity through metamorphosis. The mechanism producing the gap is unknown. Here, by combining gene functional analyses, pharmacological analyses, and live imaging, we propose that the gap represents the time required for sufficient cyclic adenosine monophosphate (cAMP) accumulation to trigger metamorphosis. Not only the Gs pathway but also the Gi and Gq pathways are involved in the initiation of metamorphosis in the downstream signaling cascade of the neurotransmitter GABA, the known initiator of Ciona metamorphosis. The mutual crosstalk of stimulatory and inhibitory G-proteins functions as the accelerator and brake for cAMP production, ensuring the faithful initiation of metamorphosis at an appropriate time and in the right situation. en-copyright= kn-copyright= en-aut-name=HozumiAkiko en-aut-sei=Hozumi en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TotsukaNozomu M en-aut-sei=Totsuka en-aut-mei=Nozomu M kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OnoderaArata en-aut-sei=Onodera en-aut-mei=Arata kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WangYanbin en-aut-sei=Wang en-aut-mei=Yanbin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=HamadaMayuko en-aut-sei=Hamada en-aut-mei=Mayuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShiraishiAkira en-aut-sei=Shiraishi en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SatakeHonoo en-aut-sei=Satake en-aut-mei=Honoo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HorieTakeo en-aut-sei=Horie en-aut-mei=Takeo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HottaKohji en-aut-sei=Hotta en-aut-mei=Kohji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=SasakuraYasunori en-aut-sei=Sasakura en-aut-mei=Yasunori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Shimoda Marine Research Center, University of Tsukuba kn-affil= affil-num=2 en-affil=Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University kn-affil= affil-num=3 en-affil=Shimoda Marine Research Center, University of Tsukuba kn-affil= affil-num=4 en-affil=Shimoda Marine Research Center, University of Tsukuba kn-affil= affil-num=5 en-affil=Ushimado Marine Institute, Okayama University kn-affil= affil-num=6 en-affil=Bioorganic Research Institute, Suntory Foundation for Life Sciences kn-affil= affil-num=7 en-affil=Bioorganic Research Institute, Suntory Foundation for Life Sciences kn-affil= affil-num=8 en-affil=Laboratory for Single-cell Neurobiology, Graduate School of Frontier Biosciences, Osaka University kn-affil= affil-num=9 en-affil=Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University kn-affil= affil-num=10 en-affil=Shimoda Marine Research Center, University of Tsukuba kn-affil= END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Newsletter from Course for Prospective Museum Workers, Faculty of Letters, Okayama University kn-title=ŠwŒ|ˆõ‰Û’ö Newsletter ‘æ20† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=Œõ–{‡ kn-aut-sei=Œõ–{ kn-aut-mei=‡ aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼“c‘ñ– kn-aut-sei=¼“c kn-aut-mei=‘ñ– aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=•¶Šw•” affil-num=2 en-affil= kn-affil=’ÃŽR—mŠwŽ‘—¿ŠÙ END start-ver=1.4 cd-journal=joma no-vol=27 cd-vols= no-issue=1 article-no= start-page=16 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260221 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Compound heterozygosity of a novel missense variant and exonic deletion in hypomyelinating leukodystrophy 15 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hypomyelinating leukodystrophy 15 (HLD15) results from biallelic pathogenic variants in EPRS1, but exonic deletions have not been reported. We describe a 40-year-old woman with mild intellectual disability, ataxia, dystonia, and MRI showing hypomyelination. Whole-exome sequencing identified a heterozygous missense variant in the prolyl-tRNA synthetase domain of EPRS1 (c.3430 C?>?G; p.Leu1144Val, NM_004446.3), without second variant. Whole-genome sequencing revealed a heterozygous 220-bp deletion spanning exon 15 (c.1743-30_1932del), and segregation analysis confirmed compound heterozygosity. RT-PCR from lymphoblastoid cells demonstrated exon-15 skipping leading to a frameshift (p.Asn582Serfs*10) and nonsense-mediated decay, leaving predominant expression of the paternally inherited missense allele. These findings support loss-of-function for the deletion and classify c.3430 C?>?G as likely pathogenic under ACMG/AMP criteria (PM1, PM2, PM3, PP3). This case represents the first exonic deletion reported in EPRS1. The relatively mild, adult-onset phenotype broadens both mutational and clinical spectra of HLD15 and highlights the importance of structural-variant anal en-copyright= kn-copyright= en-aut-name=MitsutakeAkihiko en-aut-sei=Mitsutake en-aut-mei=Akihiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MatsukawaTakashi en-aut-sei=Matsukawa en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OrimoKenta en-aut-sei=Orimo en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UedaKunihiro en-aut-sei=Ueda en-aut-mei=Kunihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SekiTomonari en-aut-sei=Seki en-aut-mei=Tomonari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShiioYasushi en-aut-sei=Shiio en-aut-mei=Yasushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MitsuiJun en-aut-sei=Mitsui en-aut-mei=Jun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IshiuraHiroyuki en-aut-sei=Ishiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MoriHarushi en-aut-sei=Mori en-aut-mei=Harushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=TsujiShoji en-aut-sei=Tsuji en-aut-mei=Shoji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TodaTatsushi en-aut-sei=Toda en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Neurology kn-affil= affil-num=2 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Neurology kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Neurology kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Neurology kn-affil= affil-num=5 en-affil=Department of Neurology, Tokyo Teishin Hospital kn-affil= affil-num=6 en-affil=Department of Neurology, Tokyo Teishin Hospital kn-affil= affil-num=7 en-affil=Department of Precision Medicine Neurology, Graduate School of Medicine, The University of Tokyo kn-affil= affil-num=8 en-affil=Department of Neurology, Dentistry, and Pharmaceutical Sciences, Okayama University Graduate School of Medicine kn-affil= affil-num=9 en-affil=Department of Radiology, School of Medicine, Jichi Medical University, kn-affil= affil-num=10 en-affil=Institute of Medical Genomics, International University of Health and Welfare kn-affil= affil-num=11 en-affil=Department of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan Department of Neurology kn-affil= en-keyword=Hypomyelinating leukodystrophy kn-keyword=Hypomyelinating leukodystrophy en-keyword=EPRS1 kn-keyword=EPRS1 en-keyword=Structural variant kn-keyword=Structural variant en-keyword=Exon deletion kn-keyword=Exon deletion en-keyword=Nonsense?mediated decay kn-keyword=Nonsense?mediated decay en-keyword=Whole?genome sequencing kn-keyword=Whole?genome sequencing END start-ver=1.4 cd-journal=joma no-vol=414 cd-vols= no-issue= article-no= start-page=578885 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=202605 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Immuno-deficient features of thymoma-associated myasthenia gravis patients with hypogammaglobulinemia: A condition comparable to Good's syndrome en-subtitle= kn-subtitle= en-abstract= kn-abstract=Good's syndrome (GS) is a rare immunodeficiency disorder associated with thymoma, characterized by hypogammaglobulinemia and recurrent infections; however, its clinical significance in thymoma-associated myasthenia gravis (TAMG) remains unclear. We retrospectively reviewed 30 patients with TAMG admitted to our center between January 2010 and March 2022. We defined GS-like immunodeficiency as serum IgG below the institutional cutoff of 861 mg/dL and a history of two or more infections requiring antimicrobial treatment; 11 patients (36.7%) met this definition. Compared with the remaining patients, the GS-like group had higher incidences of malignancy (45.5% vs. 5.3%, p = 0.016) and autoimmune diseases other than MG (36.4% vs. 5.3%, p = 0.047), lower peripheral lymphocyte counts (median 1100/ƒÊL vs. 2200/ƒÊL, p = 0.0051), and more frequent airflow obstruction defined by one second to forced vital capacity ratio of less than 70% (60.0% vs. 5.3%, p = 0.0026). Five deaths occurred in the GS-like group, and none in the other; median survival from the first antimicrobial-treated infection was 5.0 years. These findings imply that TAMG patients with GS-like immunodeficiency have a worse prognosis, underscoring the need for close monitoring and timely adjustments of MG management. (189 words). en-copyright= kn-copyright= en-aut-name=NakashimaSaki en-aut-sei=Nakashima en-aut-mei=Saki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SakuishiKaori en-aut-sei=Sakuishi en-aut-mei=Kaori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HaraManato en-aut-sei=Hara en-aut-mei=Manato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KawasakiReiko en-aut-sei=Kawasaki en-aut-mei=Reiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KakumotoToshiyuki en-aut-sei=Kakumoto en-aut-mei=Toshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=IshiuraHiroyuki en-aut-sei=Ishiura en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TodaTatsushi en-aut-sei=Toda en-aut-mei=Tatsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Neurology, Graduate School of Medicine, the University of Tokyo kn-affil= affil-num=2 en-affil=Department of Neurology, Teikyo University Chiba Medical Center kn-affil= affil-num=3 en-affil=Department of Neurology, Graduate School of Medicine, the University of Tokyo kn-affil= affil-num=4 en-affil=Department of Neurology, Graduate School of Medicine, the University of Tokyo kn-affil= affil-num=5 en-affil=Department of Neurology, Graduate School of Medicine, the University of Tokyo kn-affil= affil-num=6 en-affil=Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=7 en-affil=Department of Neurology, Graduate School of Medicine, the University of Tokyo kn-affil= en-keyword=Good's syndrome kn-keyword=Good's syndrome en-keyword=Thymoma-associated myasthenia gravis kn-keyword=Thymoma-associated myasthenia gravis en-keyword=Hypogammaglobulinemia kn-keyword=Hypogammaglobulinemia en-keyword=Immunodeficiency kn-keyword=Immunodeficiency en-keyword=Prognosis kn-keyword=Prognosis END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue=50 article-no= start-page=e06926 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251031 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery in a 3D Model of Pancreatic Cancer Fibrosis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fibrosis is a significant barrier to drug delivery in pancreatic ductal adenocarcinoma (PDAC) and contributes to its dismal prognosis. Pancreatic stellate cells (PSCs) drive fibrosis by excessively secreting extracellular matrix proteins such as collagen I. Collagen I is thought to physically obstruct the delivery of macromolecules, such as albumin, antibodies, and nanomedicines. Apart from its structural role, collagen signals through dedicated cell surface receptors, such as the discoidin domain receptors (DDR) 1/2. However, whether and how collagen signaling contributes to fibrotic barrier generation remains uncharacterized. Here, a 3D culture model of PDAC fibrosis constructed from patient PSCs is used to assess the contribution of DDR1/2-mediated collagen signaling. DDR1/2 inhibition diminishes collagen I expression in PSCs to enhance macromolecular delivery. Moreover, MEK inhibitors exacerbate the fibrotic barrier by up-regulating collagen I, an effect reversed by inhibiting DDR1/2. Through isoform-specific targeting, inhibiting DDR1, but not DDR2, is shown to be effective. Downstream of DDR, the involvement of the PI3K/AKT/mTOR pathway is demonstrated, particularly alternative mTOR complexes involving MEAK7 and GIT1. Altogether, the results show in vitro that DDR1-mediated collagen signaling exacerbates the fibrotic barrier and may be targeted to enhance macromolecular drug delivery in PDAC. en-copyright= kn-copyright= en-aut-name=OhiraMayu en-aut-sei=Ohira en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitamuraMoe en-aut-sei=Kitamura en-aut-mei=Moe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IwasakiHiroyo en-aut-sei=Iwasaki en-aut-mei=Hiroyo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=Ohta]OkanoHaruko en-aut-sei=Ohta]Okano en-aut-mei=Haruko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TsujiiHiyori en-aut-sei=Tsujii en-aut-mei=Hiyori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakamuraReika en-aut-sei=Nakamura en-aut-mei=Reika kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakazawaTakuya en-aut-sei=Nakazawa en-aut-mei=Takuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NishiguchiAkihiro en-aut-sei=Nishiguchi en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=YamamotoMasaya en-aut-sei=Yamamoto en-aut-mei=Masaya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OsadaKensuke en-aut-sei=Osada en-aut-mei=Kensuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=ToyookaShinichi en-aut-sei=Toyooka en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=CabralHoracio en-aut-sei=Cabral en-aut-mei=Horacio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MasamuneAtsushi en-aut-sei=Masamune en-aut-mei=Atsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KanoMitsunobu R. en-aut-sei=Kano en-aut-mei=Mitsunobu R. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TanakaHiroyoshi Y. en-aut-sei=Tanaka en-aut-mei=Hiroyoshi Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= affil-num=1 en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=8 en-affil=Biomaterials Field, Research Center for Macromolecules and Biomaterials, National Institute for Materials Science kn-affil= affil-num=9 en-affil=Department of Materials Processing, Graduate School of Engineering, Tohoku University kn-affil= affil-num=10 en-affil=Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Sciences and Technology (QST) kn-affil= affil-num=11 en-affil=Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=12 en-affil=Department of Bioengineering, Graduate School of Engineering, The University of Tokyo kn-affil= affil-num=13 en-affil=Division of Gastroenterology, Graduate School of Medicine, Tohoku University kn-affil= affil-num=14 en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University kn-affil= affil-num=15 en-affil=Department of Pharmaceutical Biomedicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=collagen kn-keyword=collagen en-keyword=fibrosis kn-keyword=fibrosis en-keyword=nanomedicine kn-keyword=nanomedicine en-keyword=pancreatic cancer kn-keyword=pancreatic cancer en-keyword=pancreatic stellate cell kn-keyword=pancreatic stellate cell END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=1 article-no= start-page=120 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251124 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comparison of clinical practices during the transitional and young adult phases between patients with oligoarticular/polyarticular juvenile idiopathic arthritis and those with rheumatoid arthritis in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background Juvenile idiopathic arthritis (JIA) is a chronic inflammatory condition that frequently persists into adulthood, posing long-term challenges in disease control and quality of life. However, clinical management during the transitional and young adult phases remains insufficiently characterized, especially in comparison with adult-onset rheumatoid arthritis (RA). This study aimed to compare disease activity, medication use, and treatment practices between patients with oligoarticular/polyarticular JIA and those with RA, focusing on individuals aged 16?30 years.
Methods Data were derived from two nationwide multicenter databases in Japan?NinJa (National Database of Rheumatic Diseases in Japan) for RA and CoNinJa (a pediatric counterpart of NinJa) for JIA. A total of 176 JIA and 152 RA patients, all aged 16?30 years, were analyzed. Clinical parameters, disease activity indices, and medication profiles were compared using the Mann?Whitney U test and Fisherfs exact test.
Results Compared to RA patients, JIA patients demonstrated significantly lower disease activity (median SDAI 0.6 vs. 2.4) and higher remission rates, particularly Boolean remission (70% vs. 44%) (p? Conclusions Despite an overlap in age, patients with JIA and RA exhibit distinct disease characteristics and therapeutic patterns. These differences underscore the need to expand approved treatment options for JIA, promote equitable access to biologics, and strengthen transitional care frameworks. Further research is warranted to explore long-term outcomes, reproductive health considerations, and socioeconomic barriers that influence treatment continuity in young adults with childhood-onset arthritis. en-copyright= kn-copyright= en-aut-name=MoriSho en-aut-sei=Mori en-aut-mei=Sho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShabanaKosuke en-aut-sei=Shabana en-aut-mei=Kosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuiToshihiro en-aut-sei=Matsui en-aut-mei=Toshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=NozawaTomo en-aut-sei=Nozawa en-aut-mei=Tomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SugitaYuko en-aut-sei=Sugita en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TomiitaMinako en-aut-sei=Tomiita en-aut-mei=Minako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakagishiYasuo en-aut-sei=Nakagishi en-aut-mei=Yasuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=YamasakiYuichi en-aut-sei=Yamasaki en-aut-mei=Yuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=UmebayashiHiroaki en-aut-sei=Umebayashi en-aut-mei=Hiroaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YashiroMasato en-aut-sei=Yashiro en-aut-mei=Masato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IwataNaomi en-aut-sei=Iwata en-aut-mei=Naomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=YasumuraJunko en-aut-sei=Yasumura en-aut-mei=Junko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=WakiguchiHiroyuki en-aut-sei=Wakiguchi en-aut-mei=Hiroyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=YamamotoTakeshi en-aut-sei=Yamamoto en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TakezakiShunichiro en-aut-sei=Takezaki en-aut-mei=Shunichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=OkuraYuka en-aut-sei=Okura en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=YokoyamaTadafumi en-aut-sei=Yokoyama en-aut-mei=Tadafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= en-aut-name=ShimizuMasaki en-aut-sei=Shimizu en-aut-mei=Masaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=18 ORCID= en-aut-name=HirayamaMasahiro en-aut-sei=Hirayama en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=19 ORCID= en-aut-name=TohmaShigeto en-aut-sei=Tohma en-aut-mei=Shigeto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=20 ORCID= en-aut-name=OkamotoNami en-aut-sei=Okamoto en-aut-mei=Nami kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=21 ORCID= en-aut-name=MoriMasaaki en-aut-sei=Mori en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=22 ORCID= affil-num=1 en-affil=Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine kn-affil= affil-num=2 en-affil=Department of Pediatrics, Osaka Medical and Pharmaceutical University kn-affil= affil-num=3 en-affil=Department of Rheumatology Research, Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital kn-affil= affil-num=4 en-affil=Department of Pediatrics, Graduate School of Medicine, Yokohama City University kn-affil= affil-num=5 en-affil=Department of Pediatrics, Osaka Medical and Pharmaceutical University kn-affil= affil-num=6 en-affil=Department of Allergy and Rheumatology, Chiba Childrenfs Hospital kn-affil= affil-num=7 en-affil=Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Childrenfs Hospital kn-affil= affil-num=8 en-affil=Department of Pediatrics, Kagoshima University Hospital kn-affil= affil-num=9 en-affil=Department of General Pediatrics, Miyagi Childrenfs Hospital kn-affil= affil-num=10 en-affil=Department of Pediatrics, Okayama University Hospital kn-affil= affil-num=11 en-affil=Department of Infection and Immunology, Allergy and Immunology Center, Aichi Childrenfs Health and Medical Center kn-affil= affil-num=12 en-affil=Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences kn-affil= affil-num=13 en-affil=Department of Pediatrics, Yamaguchi University Graduate School of Medicine kn-affil= affil-num=14 en-affil=Department of Pediatrics, Chiba University Graduate School of Medicine kn-affil= affil-num=15 en-affil=Department of Pediatrics, Faculty of Medicinea and Graduate School of Medicine, Hokkaido University kn-affil= affil-num=16 en-affil=Center for Pediatric Allergy and Rheumatology, KKR Sapporo Medical Center kn-affil= affil-num=17 en-affil=Department of Pediatrics, Kanazawa University kn-affil= affil-num=18 en-affil=Department of Pediatrics, Perinatal and Maternal Medicine, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo kn-affil= affil-num=19 en-affil=Department of Pediatrics, Mie University Graduate School of Medicine kn-affil= affil-num=20 en-affil=Department of Rheumatology, National Hospital Organization Tokyo National Hospital kn-affil= affil-num=21 en-affil=Department of Pediatrics, Osaka Medical and Pharmaceutical University kn-affil= affil-num=22 en-affil=Division of Rheumatology and Allergology, Department of Internal Medicine, St. Marianna University School of Medicine kn-affil= en-keyword=Juvenile idiopathic arthritis kn-keyword=Juvenile idiopathic arthritis en-keyword=Rheumatoid arthritis kn-keyword=Rheumatoid arthritis en-keyword=Disease activity kn-keyword=Disease activity en-keyword=Biologics kn-keyword=Biologics en-keyword=Methotrexate kn-keyword=Methotrexate END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=— •\Ž†E‰p•¶–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page=100 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On Ten-nyoiHeavenly Maidensj with Wings, Part 12: The Ceiling of the Imperial Theatre by Wada Eisaku and its Cont ext kn-title=u—L—ƒ‚Ì“V—}v\“ñl „Ÿ ˜a“c‰pì‚É‚æ‚é’é‘Œ€êŠÏ——È‚Ì“Vˆä‰æ‚Æ‚»‚ÌŽü•Ó „Ÿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TATSUNOYuko en-aut-sei=TATSUNO en-aut-mei=Yuko kn-aut-name=—´–ì—LŽq kn-aut-sei=—´–ì kn-aut-mei=—LŽq aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page=63 end-page=77 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Academic Contribution of the Teaching Staff of the Faculty of Letters, Okayama Universityi2024j kn-title=•¶Šw•”‹³ˆõŒ¤‹†Šˆ“®ˆê——i2024”N“xj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page=51 end-page=62 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=eKano daf and eFukano daf as Expressions of Potential in Japanese kn-title=‰Â”\•\Œ»‚Æ‚µ‚Ä‚Ìu‰Â”\‚¾vu•s‰Â”\‚¾v en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MIYAZAKIKazuhito en-aut-sei=MIYAZAKI en-aut-mei=Kazuhito kn-aut-name=‹{è˜al kn-aut-sei=‹{è kn-aut-mei=˜al aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page=39 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Inheritance and Changes of Accents in the Hiroshima City Dialecti1j: Generational Variation in One-, Two-, and Three-Mora Nouns kn-title=L“‡Žs•ûŒ¾‚É‚¨‚¯‚éƒAƒNƒZƒ“ƒg‚ÌŒp³‚Æ•Ï—ei1j„Ÿ 1 ”E2 ”E3 ”–¼ŽŒ‚̃AƒNƒZƒ“ƒg‚Ì¢‘ã“I“®‘Ô „Ÿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NAKATOYasue en-aut-sei=NAKATO en-aut-mei=Yasue kn-aut-name=’†“Œ–õŒb kn-aut-sei=’†“Œ kn-aut-mei=–õŒb aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page=29 end-page=37 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=eArmenia between Byzantium, the Seljuks and the Crusades: An Annotated Translation of the History of Abdlmseh and His Sons kn-title=ƒrƒUƒ“ƒcŽx”zAƒZƒ‹ƒWƒ…[ƒN’©N“üA‚»‚µ‚Ä\ŽšŒR“ž—ˆ‚Ì‹·ŠÔ‚Å „Ÿ ƒAƒ‹ƒƒjƒAŒêŽj—¿wƒAƒuƒhƒ‹ƒ€ƒZƒt‚Æ‚»‚ÌŽq‘·‚½‚¿‚Ì—ðŽjx–ó’i2j en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NAKADAKosuke en-aut-sei=NAKADA en-aut-mei=Kosuke kn-aut-name=’‡“cŒö•ã kn-aut-sei=’‡“c kn-aut-mei=Œö•ã aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page=13 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Events Commemorating VJ Day 80 and a Special Exhibition in Berlin, Germany kn-title=íŒã80Žü”N‚̉p‘‚̑ΓúퟋL”O“úiVJ ƒfƒCj‚̵‚¨‚æ‚уhƒCƒcEƒxƒ‹ƒŠƒ“‚ÌŠé‰æ“W en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NAKAOTomoyo en-aut-sei=NAKAO en-aut-mei=Tomoyo kn-aut-name=’†”ö’m‘ã kn-aut-sei=’†”ö kn-aut-mei=’m‘ã aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page=1 end-page=11 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Characteristics of Sustainable Development and Regional Responses in Small Municipalities in Non-Metropolitan Areas kn-title=”ñ‘å“sŽsŒ—¬‹K–ÍŽ©Ž¡‘Ì‚ÌŽ‘±“I”­“W‚Æ’nˆæ“I‘Ήž‚Ì“Á’¥ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KITAGAWAHirofumi en-aut-sei=KITAGAWA en-aut-mei=Hirofumi kn-aut-name=–k씎Žj kn-aut-sei=–kì kn-aut-mei=”ŽŽj aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=78 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251212 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=5 article-no= start-page=1003 end-page=1015 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20251222 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Claudin-18 expression in gastric type adenocarcinoma and HPV-associated adenocarcinoma of the uterine cervix en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aims: Claudin-18 (CLDN18) is both a marker for the gastric phenotype and a therapeutic target. However, little is known about its immunoexpression in endocervical adenocarcinomas (ECAs), particularly as detected using the clone 43-14A antibody, or about the gene expression of its isoforms in ECAs.
Methods and results: We examined CLDN18, HIK1083, p16 and Rb expression by immunohistochemistry and high-risk human papillomavirus (HR-HPV) mRNA by in situ hybridization (ISH) in 121 ECAs, including 35 HPV-independent adenocarcinomas (gastric type [GAS], n?=?24; non-GAS, n?=?11) and 86 HPV-associated ECAs. We also analysed mRNA expression of the CLDN18.1 (lung type) and CLDN18.2 (gastric type) isoforms by quantitative polymerase chain reaction (qPCR) in selected cases. CLDN18 positivity was detected in 8/24 (33%) GASs, 0/11 (0%) non-GASs and 2/86 (2%) HPV-associated ECAs, with positivity defined as staining in ?75% of tumour cells, as in gastric cancer. When a 5% cut-off was used, CLDN18 positivity was detected in 22/24 (92%) GASs, 0/11 (0%) non-GASs and 6/86 (7%) HPV-associated ECAs; CLDN18 expression was thus significantly associated with GAS histology (P? Conclusions: CLDN18 (43-14A) emerged as a potential diagnostic and therapeutic marker for GAS. A minor subset of HPV-associated ECAs also can be immunoreactive for CLDN18 and express CLDN18.2 mRNA, suggesting divergent gastric phenotypic differentiation. The caution is that GAS and HPV-associated ECAs can share overlapping histological features and similar expression of CLDN18 and p16. en-copyright= kn-copyright= en-aut-name=YasutakeNobuko en-aut-sei=Yasutake en-aut-mei=Nobuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YokawaYuki en-aut-sei=Yokawa en-aut-mei=Yuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MishimaRiri en-aut-sei=Mishima en-aut-mei=Riri kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KomamizuMisato en-aut-sei=Komamizu en-aut-mei=Misato kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KugaRyosuke en-aut-sei=Kuga en-aut-mei=Ryosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=JiromaruRina en-aut-sei=Jiromaru en-aut-mei=Rina kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KawatokoShinichiro en-aut-sei=Kawatoko en-aut-mei=Shinichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SonodaKenzo en-aut-sei=Sonoda en-aut-mei=Kenzo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YahataHideaki en-aut-sei=Yahata en-aut-mei=Hideaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KatoKiyoko en-aut-sei=Kato en-aut-mei=Kiyoko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=OdaYoshinao en-aut-sei=Oda en-aut-mei=Yoshinao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=YamamotoHidetaka en-aut-sei=Yamamoto en-aut-mei=Hidetaka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=2 en-affil=Department of Pathology and Oncology, Graduate School of Medicine, Dentistry & Pharmaceutical Science, Okayama University kn-affil= affil-num=3 en-affil=Department of Pathology and Oncology, Graduate School of Medicine, Dentistry & Pharmaceutical Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Pathology and Oncology, Graduate School of Medicine, Dentistry & Pharmaceutical Science, Okayama University kn-affil= affil-num=5 en-affil=Department of Gynecology and Obstetrics, Graduate School of Medical Sciences Kyushu University Fukuoka Japan kn-affil= affil-num=6 en-affil=Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=7 en-affil=Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=8 en-affil=Department of Medicine and Clinical Science, Kyushu University Beppu Hospital kn-affil= affil-num=9 en-affil=Department of Gynecology, Kyushu University Beppu Hospital kn-affil= affil-num=10 en-affil=Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=11 en-affil=Department of Gynecology and Obstetrics, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=12 en-affil=Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University kn-affil= affil-num=13 en-affil=Department of Pathology and Oncology, Graduate School of Medicine, Dentistry & Pharmaceutical Science, Okayama University kn-affil= en-keyword=claudin-18 kn-keyword=claudin-18 en-keyword=endocervical adenocarcinoma kn-keyword=endocervical adenocarcinoma en-keyword=gastric type kn-keyword=gastric type en-keyword=human papillomavirus kn-keyword=human papillomavirus en-keyword=p16 kn-keyword=p16 END start-ver=1.4 cd-journal=joma no-vol=191 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260228 dt-online= en-article= kn-article= en-subject= kn-subject= 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en-aut-sei=TAKEMOTO en-aut-mei=Toshiya kn-aut-name=’|–{rÆ kn-aut-sei=’|–{ kn-aut-mei=rÆ aut-affil-num=11 ORCID= en-aut-name=SAWATANIYoko en-aut-sei=SAWATANI en-aut-mei=Yoko kn-aut-name=àV’J—zŽq kn-aut-sei=àV’J kn-aut-mei=—zŽq aut-affil-num=12 ORCID= en-aut-name=KAJIIKazuaki en-aut-sei=KAJII en-aut-mei=Kazuaki kn-aut-name=Šˆäˆê‹Å kn-aut-sei=Šˆä kn-aut-mei=ˆê‹Å aut-affil-num=13 ORCID= en-aut-name=KANAGAWAMakiko en-aut-sei=KANAGAWA en-aut-mei=Makiko kn-aut-name=‹àì•‘‹MŽq kn-aut-sei=‹àì kn-aut-mei=•‘‹MŽq aut-affil-num=14 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Okayama University Kindergarten kn-affil=‰ªŽR‘åŠw•‘®—c’t‰€ affil-num=3 en-affil=Okayama University Kindergarten kn-affil=‰ªŽR‘åŠw•‘®—c’t‰€ affil-num=4 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=5 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=6 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=7 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=8 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=9 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=10 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=11 en-affil=Okayama University School for Special Needs Education kn-affil=‰ªŽR‘åŠw•‘®“Á•ÊŽx‰‡ŠwZ affil-num=12 en-affil=Okayama University School for Special Needs Education kn-affil=‰ªŽR‘åŠw•‘®“Á•ÊŽx‰‡ŠwZ affil-num=13 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=14 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ en-keyword=‹³EˆõŒ¤C kn-keyword=‹³EˆõŒ¤C en-keyword=‚“x‰» kn-keyword=‚“x‰» en-keyword=‘åŠw kn-keyword=‘åŠw en-keyword=NITS kn-keyword=NITS en-keyword=ê–åE‚Æ‚µ‚Ä‚Ì‹³Eˆõ kn-keyword=ê–åE‚Æ‚µ‚Ä‚Ì‹³Eˆõ END start-ver=1.4 cd-journal=joma no-vol=191 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=•\Ž†E–ÚŽŸ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue=2 article-no= start-page=284 end-page=293 dt-received= dt-revised= dt-accepted= dt-pub-year=2026 dt-pub=20260201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Clinical Characteristics and Spatial Transcriptome Analysis of Non?Small Cell Lung Cancers Exhibiting Early Alectinib Resistance: A Retrospective OLCSG Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=Some anaplastic lymphoma kinase (ALK) gene rearrangement?positive lung cancers show early resistance, within 3 months, to alectinib. This study investigated the clinical and molecular characteristics of these patients. We analyzed patients with unresectable stage III/IV disease without indications for radical radiotherapy and recurrent ALK-positive lung cancer who received alectinib as the primary ALK tyrosine kinase inhibitor between 2013 and 2021 at nine hospitals. In total, 103 patients were included. The median age was 65 years; 44 were male and 22 had brain metastases. The median progression-free survival and overall survival (OS) were 28.7 and 80.6 months. Nineteen patients treated for ?3 months and 84 treated for >3 months were categorized into the early resistance and responder groups, respectively. The early resistance group had significantly shorter OS (8.4 months vs. not estimable, P < 0.001) and was significantly more likely to have brain metastases (42% vs. 17%, P = 0.027). They also showed elevated inflammatory markers, including neutrophil-to-lymphocyte ratio (NLR). Univariate analysis identified brain metastases and high NLR as significant predictors of early resistance. Spatial transcriptome analysis and immunohistochemical staining revealed upregulation of annexin A1 (ANXA1), a calcium-dependent phospholipid-binding protein involved in inflammation and cancer progression, in the early resistance group. Interleukin 6 stimulation, prompted by elevated inflammatory markers, increased ANXA1 expression and reduced alectinib sensitivity. Knockdown of ANXA1 improved alectinib sensitivity in alectinib-resistant cells. In conclusion, brain metastases and high NLR are associated with early resistance. ANXA1 may play an important role in mediating early resistance. New treatment options for the early resistance group are required. en-copyright= kn-copyright= en-aut-name=KuribayashiTadahiro en-aut-sei=Kuribayashi en-aut-mei=Tadahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MakimotoGo en-aut-sei=Makimoto en-aut-mei=Go kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhashiKadoaki en-aut-sei=Ohashi en-aut-mei=Kadoaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TomidaShuta en-aut-sei=Tomida en-aut-mei=Shuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=InoueHirofumi en-aut-sei=Inoue en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YokoyamaToshihide en-aut-sei=Yokoyama en-aut-mei=Toshihide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KuyamaShoichi en-aut-sei=Kuyama en-aut-mei=Shoichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KatoYuka en-aut-sei=Kato en-aut-mei=Yuka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KudoKenichiro en-aut-sei=Kudo en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=HoritaNaokatsu en-aut-sei=Horita en-aut-mei=Naokatsu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=KayataniHiroe en-aut-sei=Kayatani en-aut-mei=Hiroe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=InoueMasaaki en-aut-sei=Inoue en-aut-mei=Masaaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=SugimotoKeisuke en-aut-sei=Sugimoto en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=NinomiyaKiichiro en-aut-sei=Ninomiya en-aut-mei=Kiichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=MaedaYoshinobu en-aut-sei=Maeda en-aut-mei=Yoshinobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=TogashiYosuke en-aut-sei=Togashi en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=HottaKatsuyuki en-aut-sei=Hotta en-aut-mei=Katsuyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= affil-num=1 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=2 en-affil=Department of Respiratory Medicine, Okayama University Hospital kn-affil= affil-num=3 en-affil=Department of Respiratory Medicine, Okayama University Hospital kn-affil= affil-num=4 en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital kn-affil= affil-num=5 en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital kn-affil= affil-num=6 en-affil=Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital kn-affil= affil-num=7 en-affil=Department of Respiratory Medicine, NHO Iwakuni Clinical Center kn-affil= affil-num=8 en-affil=Department of Thoracic Oncology and Medicine, National Hospital Organization, Shikoku Cancer Center kn-affil= affil-num=9 en-affil=Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center kn-affil= affil-num=10 en-affil=Department of Respiratory Medicine, Kure Kyosai Hospital kn-affil= affil-num=11 en-affil=Department of Respiratory Medicine, Japanese Red Cross Okayama Hospital kn-affil= affil-num=12 en-affil=Department of Chest Surgery, Shimonoseki City Hospital kn-affil= affil-num=13 en-affil=Department of Respiratory Medicine, Japanese Red Cross Kobe Hospital kn-affil= affil-num=14 en-affil=Center for Comprehensive Genomic Medicine, Okayama University Hospital kn-affil= affil-num=15 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil= affil-num=16 en-affil=Department of Respiratory Medicine, Okayama University Hospital kn-affil= affil-num=17 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil= END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue=3 article-no= start-page=179 end-page=187 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250901 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis and applications of porous carbonaceous materials with inherited molecular structural features from the precursor molecules en-subtitle= kn-subtitle= en-abstract= kn-abstract=The carbonization of organic crystalline materials, such as metal organic frameworks and covalent organic frameworks, has emerged as a promising approach for producing functional porous carbonaceous materials. However, both the chemically defined long-term ordered structures and the local chemical structures derived from these precursor materials are generally lost, resulting in amorphous carbons. As a result, controlling the molecular-level structure of nanoporous carbons remains a significant challenge. We report a new bottom-up synthesis approach for porous carbons with a molecular-level design, involving the carbonization of well-designed precursor molecules by thermal polymerization. Among the resulting carbons, ordered carbonaceous frameworks, which contain a high-density of regularly aligned single-atomic metal species, have been identified as promising platforms for single-atom catalysts. This approach also enables the synthesis of various three-dimensional porous carbons that reflect the structural features of their precursor molecules. Recent progress in the synthesis and applications of porous carbons derived from molecular precursors is summarized, highlighting their potential for the development of functional materials. en-copyright= kn-copyright= en-aut-name=ChidaKoki en-aut-sei=Chida en-aut-mei=Koki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshiTakeharu en-aut-sei=Yoshi en-aut-mei=Takeharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NishinaYuta en-aut-sei=Nishina en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KamiyaKazuhide en-aut-sei=Kamiya en-aut-mei=Kazuhide kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SakamotoRyota en-aut-sei=Sakamoto en-aut-mei=Ryota kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OgoshiTomoki en-aut-sei=Ogoshi en-aut-mei=Tomoki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=NishiharaHirotomo en-aut-sei=Nishihara en-aut-mei=Hirotomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Institute of Multidisciplinary Research for Advanced Materials, Tohoku University kn-affil= affil-num=2 en-affil=Institute of Multidisciplinary Research for Advanced Materials, Tohoku University kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Research Center for Solar Energy Chemistry, Graduate School of Engineering Science, The University of Osaka kn-affil= affil-num=5 en-affil=Department of Chemistry, Graduate School of Science, Tohoku University kn-affil= affil-num=6 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=7 en-affil=Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University kn-affil= affil-num=8 en-affil=Institute of Multidisciplinary Research for Advanced Materials, Tohoku University kn-affil= en-keyword=Ordered carbonaceous frameworks (OCFs) kn-keyword=Ordered carbonaceous frameworks (OCFs) en-keyword=Porous carbon materials kn-keyword=Porous carbon materials en-keyword=Single-atom catalysts (SACs) kn-keyword=Single-atom catalysts (SACs) en-keyword=Catalyst supports kn-keyword=Catalyst supports END