電気刺戟（in vitro）の脳物質代謝におよぼす影響 第1編 電気刺戟（in vitro）の大脳組織呼吸におよぼす影響

1) K. R. P.溶液中のダイコクネズミ大脳皮質切片及びホモジネートにin vitro電気刺戟を加え,ブドウ糖及びグルタミン酸基質における組織呼吸を調べた. 2) ブドウ糖基質ホモジネートでは,電気刺戟によつて,その呼吸は70%近く促進された. 3) 大脳皮質切片の電気刺戟による呼吸促進率は, 12mMブドウ糖基質では平均463%, M50グルタミン酸基質では平均270%であつた. 4) 尚,グルタミン酸基質の場合,切片の小さい方が呼吸促進率は大のようであつた. 5) 又,基質なしでも電気刺戟によつて相当の呼吸促進がみられた. 6) ブドウ糖基質大脳皮質切片に, Augospelによる電気刺戟を加えた場合の呼吸促進率は244%であつた.

Using slices and homogenates of the cerebral cortex of albino rats in the K.R.P. solution with glucose and glutamic acids as substrate, the author studied the tissue respiration in vitro giving electrical stimualtion, and obtained the following results. 1. In the case with the use of homogenate with glucose the tissue respiration was accelerated about 70 per cent by the electrical stimulation. 2. The percentage of the acceleration in the tissue respiration by electrical Stimulation in the case of cerebral slices was 463 percent on the average with 12 mM glucose as substrate, and 270 per cent on the average with M/50 glutamic acid as substrate. 3. In addition, it seems that in the case using glutamic acid smaller slices yield higher acceleration of the tissue respiration. 4. Even without glucose as substrate the respiration is considerably accelerated by electrical stimulation. 5. In the case where the electrical stimulation is given by Augospel apparatus (a low frequency therapeutic apparatus) to the cerebral cortex slices with glucose as substrate, the percentage of the respiration acceleration was 244 per cent.