start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=25 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The advances in robot-assisted surgery in the field of urology and future perspective kn-title=泌尿器科領域におけるロボット手術の進化と未来 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=BekkuKensuke en-aut-sei=Bekku en-aut-mei=Kensuke kn-aut-name=別宮謙介 kn-aut-sei=別宮 kn-aut-mei=謙介 aut-affil-num=1 ORCID= en-aut-name=NagasakiNaoya en-aut-sei=Nagasaki en-aut-mei=Naoya kn-aut-name=長﨑直也 kn-aut-sei=長﨑 kn-aut-mei=直也 aut-affil-num=2 ORCID= en-aut-name=OkamotoYusuke en-aut-sei=Okamoto en-aut-mei=Yusuke kn-aut-name=岡本悠佑 kn-aut-sei=岡本 kn-aut-mei=悠佑 aut-affil-num=3 ORCID= en-aut-name=ShiraishiHiromasa en-aut-sei=Shiraishi en-aut-mei=Hiromasa kn-aut-name=白石裕雅 kn-aut-sei=白石 kn-aut-mei=裕雅 aut-affil-num=4 ORCID= en-aut-name=TairaAya en-aut-sei=Taira en-aut-mei=Aya kn-aut-name=平良彩 kn-aut-sei=平良 kn-aut-mei=彩 aut-affil-num=5 ORCID= en-aut-name=InoueShota en-aut-sei=Inoue en-aut-mei=Shota kn-aut-name=井上翔太 kn-aut-sei=井上 kn-aut-mei=翔太 aut-affil-num=6 ORCID= en-aut-name=KawagoYuya en-aut-sei=Kawago en-aut-mei=Yuya kn-aut-name=川合裕也 kn-aut-sei=川合 kn-aut-mei=裕也 aut-affil-num=7 ORCID= en-aut-name=WatanabeTomofumi en-aut-sei=Watanabe en-aut-mei=Tomofumi kn-aut-name=渡部智文 kn-aut-sei=渡部 kn-aut-mei=智文 aut-affil-num=8 ORCID= en-aut-name=MitsuiMasao en-aut-sei=Mitsui en-aut-mei=Masao kn-aut-name=三井將雄 kn-aut-sei=三井 kn-aut-mei=將雄 aut-affil-num=9 ORCID= en-aut-name=HoriiSatoshi en-aut-sei=Horii en-aut-mei=Satoshi kn-aut-name=堀井聡 kn-aut-sei=堀井 kn-aut-mei=聡 aut-affil-num=10 ORCID= en-aut-name=MoriwakeTakatoshi en-aut-sei=Moriwake en-aut-mei=Takatoshi kn-aut-name=森分貴俊 kn-aut-sei=森分 kn-aut-mei=貴俊 aut-affil-num=11 ORCID= en-aut-name=YoshinagaKasumi en-aut-sei=Yoshinaga en-aut-mei=Kasumi kn-aut-name=吉永香澄 kn-aut-sei=吉永 kn-aut-mei=香澄 aut-affil-num=12 ORCID= en-aut-name=MitsuiYosuke en-aut-sei=Mitsui en-aut-mei=Yosuke kn-aut-name=光井洋介 kn-aut-sei=光井 kn-aut-mei=洋介 aut-affil-num=13 ORCID= en-aut-name=YamanoiTomoaki en-aut-sei=Yamanoi en-aut-mei=Tomoaki kn-aut-name=山野井友昭 kn-aut-sei=山野井 kn-aut-mei=友昭 aut-affil-num=14 ORCID= en-aut-name=KawadaTatsushi en-aut-sei=Kawada en-aut-mei=Tatsushi kn-aut-name=河田達志 kn-aut-sei=河田 kn-aut-mei=達志 aut-affil-num=15 ORCID= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name=定平卓也 kn-aut-sei=定平 kn-aut-mei=卓也 aut-affil-num=16 ORCID= en-aut-name=TominagaYusuke en-aut-sei=Tominaga en-aut-mei=Yusuke kn-aut-name=富永悠介 kn-aut-sei=富永 kn-aut-mei=悠介 aut-affil-num=17 ORCID= en-aut-name=IwataTakehiro en-aut-sei=Iwata en-aut-mei=Takehiro kn-aut-name=岩田健宏 kn-aut-sei=岩田 kn-aut-mei=健宏 aut-affil-num=18 ORCID= en-aut-name=KatayamaSatoshi en-aut-sei=Katayama en-aut-mei=Satoshi kn-aut-name=片山聡 kn-aut-sei=片山 kn-aut-mei=聡 aut-affil-num=19 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name=西村慎吾 kn-aut-sei=西村 kn-aut-mei=慎吾 aut-affil-num=20 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name=枝村康平 kn-aut-sei=枝村 kn-aut-mei=康平 aut-affil-num=21 ORCID= en-aut-name=KobayashiTomoko en-aut-sei=Kobayashi en-aut-mei=Tomoko kn-aut-name=小林知子 kn-aut-sei=小林 kn-aut-mei=知子 aut-affil-num=22 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name=荒木元朗 kn-aut-sei=荒木 kn-aut-mei=元朗 aut-affil-num=23 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=2 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=3 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=4 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=5 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=6 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=7 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=10 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=11 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=12 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=13 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=14 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=15 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=16 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=17 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=18 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=19 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=20 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=21 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=22 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 affil-num=23 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　泌尿器病態学 en-keyword=ロボット手術 kn-keyword=ロボット手術 en-keyword=ダビンチ kn-keyword=ダビンチ en-keyword=泌尿器科領域 kn-keyword=泌尿器科領域 END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue= article-no= start-page=670 end-page=679 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photochemically assisted synthesis of phenacenes fluorinated at the terminal benzene rings and their electronic spectra en-subtitle= kn-subtitle= en-abstract= kn-abstract=[n]Phenacenes ([n] = 5-7), octafluorinated at the terminal benzene rings (F8-phenacenes: F8PIC, F8FUL, and F87PHEN), were photochemically synthesized, and their electronic spectra were investigated to reveal the effects of the fluorination on the electronic features of phenacene molecules. F8-Phenacenes were conveniently synthesized by the Mallory photoreaction of the corresponding fluorinated diarylethenes as the key step. Upon fluorination on the phenacene cores, the absorption and fluorescence bands of the F8-phenacenes in CHCl3 systematically red-shifted by ca. 3-5 nm compared to those of the corresponding parent phenacenes. The vibrational progressions of the absorption and fluorescence bands were little affected by the fluorination in the solution phase. In the solid state, the absorption band of F8-phenacenes appeared in the similar wavelength region for the corresponding parent phenacenes whereas their fluorescence bands markedly red-shifted and broadened. These observations suggest that the intermolecular interactions of excited-state F8-phenacene molecules are significantly different from those of the corresponding parent molecules, most likely due to different crystalline packing motifs. en-copyright= kn-copyright= en-aut-name=IshiiYuuki en-aut-sei=Ishii en-aut-mei=Yuuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=3 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=4 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=5 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=fluorescence kn-keyword=fluorescence en-keyword=fluorinated aromatics kn-keyword=fluorinated aromatics en-keyword=phenacene kn-keyword=phenacene en-keyword=photoreaction kn-keyword=photoreaction END start-ver=1.4 cd-journal=joma no-vol=188 cd-vols= no-issue= article-no= start-page=67 end-page=76 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Music Education Practice Based on the Region: An Improvisation Workshop at a Public Elementary School in Tamano City, Okayama kn-title=地域を見つめ直す音楽教育実践の検討 ― 岡山県玉野市内の公立小学校における即興演奏ワークショップを例に ― en-subtitle= kn-subtitle= en-abstract= kn-abstract=　本研究は，地域の文化や遺産，環境を念頭に置いた創造的な音楽教育によって，県内の人口減少に起因する課題の改善を図ることを目的としている。同時に，その創作教育を通じて，児童の柔軟な創造力や多様性を認める意識を育むこともねらっている。本研究において実践した取組は，現代音楽的表現を取り入れた即興演奏ワークショップである。
　本稿では2024 年に行った玉野市内の小学校におけるワークショップの内容を中心に論じる。本ワークショップは，児童が柔軟かつ多様な創作表現を実践する場となったが，児童と地域住民らがその地域の特色を認識する機会としては新たな課題を生んだ。地域と創造的音楽教育を結んだ研究は実例が少なく，模索の段階であるため，本ワークショップを省みた上で今後の改善に繋げたい。 en-copyright= kn-copyright= en-aut-name=OKAMOTOShinsuke en-aut-sei=OKAMOTO en-aut-mei=Shinsuke kn-aut-name=岡本伸介 kn-aut-sei=岡本 kn-aut-mei=伸介 aut-affil-num=1 ORCID= en-aut-name=MASUDAKenta en-aut-sei=MASUDA en-aut-mei=Kenta kn-aut-name=増田建太 kn-aut-sei=増田 kn-aut-mei=建太 aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=岡山大学学術研究院教育学域 affil-num=2 en-affil=Faculty of Education, University of Toyama kn-affil=富山大学学術研究部教育学系 en-keyword=音楽教育 kn-keyword=音楽教育 en-keyword=地域教育 kn-keyword=地域教育 en-keyword=即興演奏 kn-keyword=即興演奏 en-keyword=作曲 kn-keyword=作曲 en-keyword=現代音楽 kn-keyword=現代音楽 END start-ver=1.4 cd-journal=joma no-vol=222 cd-vols= no-issue= article-no= start-page=115374 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Environmental water in Kolkata is suitable for the survival of Vibrio cholerae O1 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Many patients with cholera emerge in Kolkata, India throughout the year. Such emergency indicates that cholera toxin-producing Vibrio cholerae O1 (toxigenic V. cholerae O1) are widespread in Kolkata. This suggests that the suitable conditions for replication of toxigenic V. cholerae O1 is provided in Kolkata. In previous studies, we found that the replication rate of toxigenic V. cholerae O1 is low in the low ionic aqueous solution. Then we measured the ion concentration in the environmental water of Kolkata. As a control, we measured them in Japanese environmental water. The ion concentration in the environmental water of Kolkata was significantly high. Then, we examined the survival of toxigenic V. cholerae O1 in groundwater from Kolkata and found that V. cholerae O1 survive for long time in the solution but not in the solution diluted with Milli Q water. In addition, we found that V. cholerae O1 proliferated in environmental water of Kolkata to which a small amount of nutrient was added, but did not grow in the environmental water diluted with water to which the same amount of nutrient was added. These results indicate that the environmental water from Kolkata is suitable for survival of V. cholerae O1. en-copyright= kn-copyright= en-aut-name=TakahashiEizo en-aut-sei=Takahashi en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ChowdhuryGoutam en-aut-sei=Chowdhury en-aut-mei=Goutam kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MukhopadhyayAsish K. en-aut-sei=Mukhopadhyay en-aut-mei=Asish K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=DuttaShanta en-aut-sei=Dutta en-aut-mei=Shanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OchiSadayuki en-aut-sei=Ochi en-aut-mei=Sadayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=2 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= affil-num=4 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=5 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=6 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=7 en-affil=Department of Health Pharmacy, Yokohama University of Pharmacy kn-affil= affil-num=8 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= en-keyword=Environmental water kn-keyword=Environmental water en-keyword=Ion kn-keyword=Ion en-keyword=Prevalence kn-keyword=Prevalence en-keyword=Survival kn-keyword=Survival en-keyword=Vibrio cholerae kn-keyword=Vibrio cholerae END start-ver=1.4 cd-journal=joma no-vol=371 cd-vols= no-issue= article-no= start-page=fnae053 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=2024 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Regulatory role of VvsB protein on serine protease activity of VvsA in Vibrio vulnificus en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background:Vibrio vulnificus NCIMB2137, a Gram-negative, metalloprotease negative estuarine strain was isolated from a diseased eel. A 45 kDa chymotrypsin-like alkaline serine protease known as VvsA has been recently reported as one of the major virulence factor responsible for the pathogenesis of this strain. The vvsA gene along with a downstream gene vvsB, whose function is still unknown constitute an operon designated as vvsAB. Objective: This study examines the contribution of VvsB to the functionality of VvsA. Method: In this study, VvsB was individually expressed using Rapid Translation System (RTS system), followed by an analysis of its role in regulating the serine protease activity of VvsA. Result: The proteolytic activity of VvsA increased upon the addition of purified VvsB to the culture supernatant of V. vulnificus. However, the attempts of protein expression using an E. coli system revealed a noteworthy observation that protein expression from the vvsA gene exhibited higher protease activity compared to that from the vvsAB gene within the cytoplasmic fraction. These findings suggest an intricate interplay between VvsB and VvsA, where VvsB potentially interacts with VvsA inside the bacterium and suppress the proteolytic activity. While outside the bacterial milieu, VvsB appears to stimulate the activation of inactive VvsA. Conclusion: The findings suggest that Vibrio vulnificus regulates VvsA activity through the action of VvsB, both intracellularly and extracellularly, to ensure its survival. en-copyright= kn-copyright= en-aut-name=KawaseTomoka en-aut-sei=Kawase en-aut-mei=Tomoka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DebnathAnusuya en-aut-sei=Debnath en-aut-mei=Anusuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Biotechnology, Brainware University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=RTS system kn-keyword=RTS system en-keyword=in vitro cell-free translation system, PU kn-keyword=in vitro cell-free translation system, PU en-keyword=Proteinase unit, VvsA kn-keyword=Proteinase unit, VvsA en-keyword=Vibrio vulnificus serine protease, SD kn-keyword=Vibrio vulnificus serine protease, SD en-keyword=Shine-Dalgarno sequence kn-keyword=Shine-Dalgarno sequence END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=8 article-no= start-page=1509 end-page=1519 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Intramolecular [π4s + π4s] photocycloaddition of carbon- and nitrogen-bridged [32](1,4)naphthalenophanes en-subtitle= kn-subtitle= en-abstract= kn-abstract=[32](1,4)Naphthalenophanes, bearing carbon-bridge chains (syn- and anti-NPs) and nitrogen-bridge chains (syn- and anti-ANPs), were synthesized, and their X-ray structures and photoreactions were investigated. The intramolecular separation distance between the naphthalene cores for ANPs was shorter than that for NPs, suggesting that intramolecular interactions between the naphthalene rings were more efficient for ANPs compared to NPs. Upon photoirradiation at 300 nm, anti-NP, syn-ANP and anti-ANP produced the corresponding intramolecular [π4s + π4s] cycloadducts, whereas syn-NP gave an unidentified complex product mixture. Quantum yields for the photo-consumption (ΦPC) of NPs and ANPs were evaluated to quantitatively compare their photoreactivity. The ΦPC values of ANPs were approximately two-fold higher than those of ANPs.Noteworthily, the ΦPC value of syn-ANP was estimated to be unity. Based on these results we discuss the effects of the alignments of the naphthalene cores (anti vs. syn) and the bridging elements (C-bridge vs. N-bridge) on the photoreaction efficiencies of [32](1,4)naphthalenophanes. en-copyright= kn-copyright= en-aut-name=OgumaYukiko en-aut-sei=Oguma en-aut-mei=Yukiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamotoMasanori en-aut-sei=Yamamoto en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SunatsukiYukinari en-aut-sei=Sunatsuki en-aut-mei=Yukinari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OtaHiromi en-aut-sei=Ota en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Department of Instrumental Analysis, Advanced Science Research Center, Okayama University kn-affil= affil-num=5 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=6 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Cyclophane kn-keyword=Cyclophane en-keyword=Azacyclophane kn-keyword=Azacyclophane en-keyword=Naphthalenophane kn-keyword=Naphthalenophane en-keyword=Photocycloaddition kn-keyword=Photocycloaddition en-keyword=[4 + 4] cycloaddition kn-keyword=[4 + 4] cycloaddition END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240516 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The optimum quantity of debt for an aging Japan: welfare and demographic dynamics en-subtitle= kn-subtitle= en-abstract= kn-abstract=Japan’s government is heavily indebted, and the current net debt tends to increase. This paper uses an extended life-cycle general equilibrium model with endogenous fertility to investigate an optimal size of government debt from two viewpoints: individual welfare and future demographic dynamics. A simulation analysis finds that the level of net government debt, which maximizes per-capita utility, is negative at − 220% of Japan’s gross domestic product (GDP). The results also indicate that the net debt-to-GDP ratio of − 220% produces a considerable per-capita welfare gain; however, compared to the baseline simulation with a debt-to-GDP ratio of 150%, it substantially decreases the total population in the long run. en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Economics, Okayama University kn-affil= en-keyword=Government debt kn-keyword=Government debt en-keyword=Welfare kn-keyword=Welfare en-keyword=Demographic dynamics kn-keyword=Demographic dynamics en-keyword=Japanese economy kn-keyword=Japanese economy en-keyword=Simulation analysis kn-keyword=Simulation analysis en-keyword=H30 kn-keyword=H30 en-keyword=C68 kn-keyword=C68 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=遊離N-グリカンの生理機能解析を目的としたエンド-β-N-アセチルグルコサミニダーゼ (ENGase) 欠損トマトの構築と植物ENGaseの糖転移活性に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKAMOTONaoko en-aut-sei=OKAMOTO en-aut-mei=Naoko kn-aut-name=岡本尚子 kn-aut-sei=岡本 kn-aut-mei=尚子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=岡山大学大学院環境生命科学研究科 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=染色体／クロマチン凝集塊移植： ミトコンドリアの持ち込みを最小限に抑えたミトコンドリア置換のための新規アプローチ-ヒト染色体凝集塊移植に対するマウス実験の意味するもの kn-title=Aggregated chromosomes/chromatin transfer: a novel approach for mitochondrial replacement with minimal mitochondrial carryover: the implications of mouse experiments for human aggregated chromosome transfer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKAMOTORyota en-aut-sei=OKAMOTO en-aut-mei=Ryota kn-aut-name=岡本遼太 kn-aut-sei=岡本 kn-aut-mei=遼太 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=452 cd-vols= no-issue= article-no= start-page=115613 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240701 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photochemical synthesis and solvatochromic fluorescence behavior of imide-fused phenacenes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Chrysenes, picene, fulminene, modified with imide, bromo, and amino functionalities, were synthesized through Mallory photoreaction as the key step, and their electronic spectra were investigated. Fluorescence spectra of chrysene-diimide CHRDI and bromo-substituted phencanene-imides, BrCHRI, BrPICI, BrFULI were dependent on solvent polarity to display appreciable fluorescence color changes. The solvatofluorochromic behavior was analyzed by conventional relationships between Stokes shift and solvent polarity parameters, such as Lippert-Mataga and Bilot-Kawski equations. The results indicated that the solvatofluorochromism was derived from the intramolecular charge transfer (ICT) nature in the excited state. Theoretical studies using time-dependent density-functional theory revealed that the phenacene-imide molecules in the fluorescent state possessed ICT characters between the strongly electron-withdrawing imide moiety and moderately electron-donating phenacene cores. Amino-substituted chrysene-imide NH2CHRI showed fluorescence band in a red region (λFL = 618 nm) in toluene with a very large Stokes shift (Δ nu= 7630 cm−1) suggesting that the molecule in the fluorescent state was highly polarized. The present results indicate that phenacenes would provide potential platforms for constructing future functional fluorophores through an appropriate functionalization. en-copyright= kn-copyright= en-aut-name=NoseKeito en-aut-sei=Nose en-aut-mei=Keito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=3 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=4 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=5 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Phenacene kn-keyword=Phenacene en-keyword=Imide kn-keyword=Imide en-keyword=Fluorescence kn-keyword=Fluorescence en-keyword=Solvatofluorochromism kn-keyword=Solvatofluorochromism en-keyword=Intramolecular charge transfer kn-keyword=Intramolecular charge transfer END start-ver=1.4 cd-journal=joma no-vol=135 cd-vols= no-issue=3 article-no= start-page=152 end-page=157 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A 4th step of visual art instruction in medical education kn-title=医学における「ビジュアルアート教育」の展開：第４ステップ― 医学教育に必要な“気づき”を与える授業― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name=木股敬裕 kn-aut-sei=木股 kn-aut-mei=敬裕 aut-affil-num=1 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name=小比賀美香子 kn-aut-sei=小比賀 kn-aut-mei=美香子 aut-affil-num=2 ORCID= en-aut-name=KuboTakuya en-aut-sei=Kubo en-aut-mei=Takuya kn-aut-name=久保卓也 kn-aut-sei=久保 kn-aut-mei=卓也 aut-affil-num=3 ORCID= en-aut-name=OtsukaMasumi en-aut-sei=Otsuka en-aut-mei=Masumi kn-aut-name=大塚益美 kn-aut-sei=大塚 kn-aut-mei=益美 aut-affil-num=4 ORCID= en-aut-name=OkamotoYuko en-aut-sei=Okamoto en-aut-mei=Yuko kn-aut-name=岡本裕子 kn-aut-sei=岡本 kn-aut-mei=裕子 aut-affil-num=5 ORCID= en-aut-name=FukutomiKoh en-aut-sei=Fukutomi en-aut-mei=Koh kn-aut-name=福冨幸 kn-aut-sei=福冨 kn-aut-mei=幸 aut-affil-num=6 ORCID= en-aut-name=MatsumotoHiroshi en-aut-sei=Matsumoto en-aut-mei=Hiroshi kn-aut-name=松本洋 kn-aut-sei=松本 kn-aut-mei=洋 aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital kn-affil=岡山大学病院　形成再建外科 affil-num=2 en-affil=Department of General Medicine, Okayama University Hospital kn-affil=岡山大学病院　総合内科・総合診療科 affil-num=3 en-affil=Department of Emergency and Critical Care Medicine, Okayama University Hospital kn-affil=岡山大学病院　救命救急科 affil-num=4 en-affil=OTSUKA DESIGN Co., Ltd. kn-affil=株式会社大塚デザイン affil-num=5 en-affil=Okayama Prefectural Museum of Art kn-affil=岡山県立美術館 affil-num=6 en-affil=Okayama Prefectural Museum of Art kn-affil=岡山県立美術館 affil-num=7 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital kn-affil=岡山大学病院　形成再建外科 END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=45 article-no= start-page=31107 end-page=31117 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=2023 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Solvation free energies of alcohols in water: temperature and pressure dependences en-subtitle= kn-subtitle= en-abstract= kn-abstract=Solvation free energies μ* of amphiphilic species, methanol and 1,2-hexanediol, are obtained as a function of temperature or pressure based on molecular dynamics simulations combined with efficient free-energy calculation methods. In general, μ* of an amphiphile can be divided into Image ID:d3cp03799a-t1.gif and Image ID:d3cp03799a-t2.gif, the nonpolar and electrostatic contributions, and the former is further divided into Image ID:d3cp03799a-t3.gif and Image ID:d3cp03799a-t4.gif which are the work of cavity formation process and the free energy change due to weak, attractive interactions between the solute molecule and surrounding solvent molecules. We demonstrate that μ* of the two amphiphilic solutes can be obtained accurately using a perturbation combining method, which relies on the exact expressions for Image ID:d3cp03799a-t5.gif and Image ID:d3cp03799a-t6.gif and requires no simulations of intermediate systems between the solute with strong, repulsive interactions and the solute with the van der Waals and electrostatic interactions. The decomposition of μ* gives us several physical insights including that μ* is an increasing function of T due to Image ID:d3cp03799a-t7.gif, that the contributions of hydrophilic groups to the temperature dependence of μ* are additive, and that the contribution of the van der Waals attraction to the solvation volume is greater than that of the electrostatic interactions. en-copyright= kn-copyright= en-aut-name=TairaAoi en-aut-sei=Taira en-aut-mei=Aoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkamotoRyuichi en-aut-sei=Okamoto en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SumiTomonari en-aut-sei=Sumi en-aut-mei=Tomonari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Information Science, University of Hyogo kn-affil= affil-num=3 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=子宮内膜癌において転移巣の分子学的特徴はより予後を反映する kn-title=Molecular Characteristics of Metastatic Lesions Have Superior Prognositc Impact on Endometrial Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKAMOTOKazuhiro en-aut-sei=OKAMOTO en-aut-mei=Kazuhiro kn-aut-name=岡本和浩 kn-aut-sei=岡本 kn-aut-mei=和浩 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=135 cd-vols= no-issue=2 article-no= start-page=85 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A third step of visual art instruction in medical education : Introduction of visual thinking strategies supported by Okayama Prefectural Museum of Art kn-title=医学における「ビジュアルアート教育」の展開：第３ステップ― 岡山県立美術館の協力による対話型鑑賞の導入― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name=木股敬裕 kn-aut-sei=木股 kn-aut-mei=敬裕 aut-affil-num=1 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name=小比賀美香子 kn-aut-sei=小比賀 kn-aut-mei=美香子 aut-affil-num=2 ORCID= en-aut-name=KuboTakuya en-aut-sei=Kubo en-aut-mei=Takuya kn-aut-name=久保卓也 kn-aut-sei=久保 kn-aut-mei=卓也 aut-affil-num=3 ORCID= en-aut-name=OtsukaMasumi en-aut-sei=Otsuka en-aut-mei=Masumi kn-aut-name=大塚益美 kn-aut-sei=大塚 kn-aut-mei=益美 aut-affil-num=4 ORCID= en-aut-name=OkamotoYuko en-aut-sei=Okamoto en-aut-mei=Yuko kn-aut-name=岡本裕子 kn-aut-sei=岡本 kn-aut-mei=裕子 aut-affil-num=5 ORCID= en-aut-name=FukutomiKoh en-aut-sei=Fukutomi en-aut-mei=Koh kn-aut-name=福冨幸 kn-aut-sei=福冨 kn-aut-mei=幸 aut-affil-num=6 ORCID= en-aut-name=MatsumotoHiroshi en-aut-sei=Matsumoto en-aut-mei=Hiroshi kn-aut-name=松本洋 kn-aut-sei=松本 kn-aut-mei=洋 aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital kn-affil=岡山大学病院　形成再建外科 affil-num=2 en-affil=Department of General Medicine, Okayama University Hospital kn-affil=岡山大学病院　総合内科・総合診療科 affil-num=3 en-affil=Department of Emergency and Critical Care Medicine, Okayama University Hospital kn-affil=岡山大学病院　救命救急科 affil-num=4 en-affil=OTSUKA DESIGN Co., Ltd. kn-affil=株式会社大塚デザイン affil-num=5 en-affil=Okayama Prefectural Museum of Art kn-affil=岡山県立美術館 affil-num=6 en-affil=Okayama Prefectural Museum of Art kn-affil=岡山県立美術館 affil-num=7 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital kn-affil=岡山大学病院　形成再建外科 END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=8 article-no= start-page=1997 end-page=2005 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230608 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Study on joint characteristics in laser butt welding of AMed and wrought Ti6Al4V plates en-subtitle= kn-subtitle= en-abstract= kn-abstract=Titanium alloy Ti6Al4V has been widely applied to medical, automotive, and aerospace industries due to its excellent properties such as high strength and excellent corrosion resistance. On the other hand, additive manufacturing (AM) technology can give the freedom of design of the products. In order to spread the AMed products, the joining of AMed and wrought products are required, and it is important to understand the joint characteristics. In this study, butt welding of Ti6Al4V plate was conducted by fiber laser in argon shielding, and the joint characteristics of laser weld wrought/wrought, AMed/AMed, and AMed/wrought Ti6Al4V plates were experimentally investigated. The AMed plate has higher tensile strength than wrought plate but the elongation of AMed plate is smaller, since AMed plate has α’ martensite due to rapid cooling during laser irradiation in AM process. Then, the laser weld joint of AMed/AMed plates has higher tensile strength, but smaller elongation than that of wrought/wrought plates. The weld joint of AMed/wrought plates shows good welding state, since small heat input leads to formation of small weld bead with higher hardness between wrought and AMed plates. en-copyright= kn-copyright= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShinonagaTogo en-aut-sei=Shinonaga en-aut-mei=Togo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakemotoYoshito en-aut-sei=Takemoto en-aut-mei=Yoshito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OchiAkihiro en-aut-sei=Ochi en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KishimotoRyuya en-aut-sei=Kishimoto en-aut-mei=Ryuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=PityanaSisa en-aut-sei=Pityana en-aut-mei=Sisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ArthurNana en-aut-sei=Arthur en-aut-mei=Nana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OmoniyiPeter en-aut-sei=Omoniyi en-aut-mei=Peter kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MahamoodRasheedat en-aut-sei=Mahamood en-aut-mei=Rasheedat kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MainaMartin en-aut-sei=Maina en-aut-mei=Martin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=AkinlabiEsther en-aut-sei=Akinlabi en-aut-mei=Esther kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Okayama University kn-affil= affil-num=2 en-affil=Okayama University kn-affil= affil-num=3 en-affil=Okayama University kn-affil= affil-num=4 en-affil=Okayama University kn-affil= affil-num=5 en-affil=Okayama University kn-affil= affil-num=6 en-affil=Okayama University kn-affil= affil-num=7 en-affil=National Laser Centre, CSIR kn-affil= affil-num=8 en-affil=National Laser Centre, CSIR kn-affil= affil-num=9 en-affil=University of Johannesburg kn-affil= affil-num=10 en-affil=University of Johannesburg kn-affil= affil-num=11 en-affil=Jomo Kenyatta University of Agriculture and Technology kn-affil= affil-num=12 en-affil=University of Johannesburg kn-affil= en-keyword=Ti6Al4V kn-keyword=Ti6Al4V en-keyword=Joint characteristics kn-keyword=Joint characteristics en-keyword=Laser welding kn-keyword=Laser welding en-keyword=Butt welding kn-keyword=Butt welding en-keyword=Additive manufacturing kn-keyword=Additive manufacturing END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cardio-ankle vascular indexによる心血管イベント予測能の改善 kn-title=Cardio-ankle vascular index as an arterial stiffness marker improves the prediction of cardiovascular events in patients without cardiovascular diseases en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKAMOTOYuko en-aut-sei=OKAMOTO en-aut-mei=Yuko kn-aut-name=岡本佑子 kn-aut-sei=岡本 kn-aut-mei=佑子 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=6 article-no= start-page=4096 end-page=4101 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Solvent-dependent fluorescence behaviour of imide-fused [n]phenacenes (n=3, 5, 7) en-subtitle= kn-subtitle= en-abstract= kn-abstract=Imide-fused [n]phenacenes (nPDIs, n = 3, 5, 7) were systematically synthesised and their electronic features were investigated by electrochemical and electronic spectral measurements. nPDIs showed two reduction waves attributed to formation of radical ions and dianions. 3PDI produced blue fluorescence independent of solvent polarity. In contrast, 5PDI and 7PDI displayed marked positive solvatofluorochromism due to intramolecular charge transfer characters between the imide moieties and phenacene pi cores in the excited state. The spectral features were analyzed by the Lippert-Mataga relationship and theoretical calculations. en-copyright= kn-copyright= en-aut-name=NoseKeito en-aut-sei=Nose en-aut-mei=Keito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshiokaKaito en-aut-sei=Yoshioka en-aut-mei=Kaito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Division of Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=4 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=5 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=6 en-affil=Division of Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=22 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20221001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Colonization with extended-spectrum beta-lactamase-producing Escherichia coli and traveler's diarrhea attack rates among travelers to India: a systematic review and meta-analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background India is an attractive destination for travelers. Unfortunately, numerous reports exist on traveler's diarrhea (TD) and fecal colonization with extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) among international travelers visiting India. Here, we systematically reviewed studies published on the acquisition of ESBL-EC and TD attack rates among international visitors to India. Methods Design: Systematic review and meta-analysis. A systematic search was performed using Google Scholar, PubMed, EMBASE, Web of Science, and gray literature from 2000 to December 2021, for studies containing data for ESBL-EC acquisition or TD experience related to a trip to India. Random effects models were used to compute the prevalence of ESBL-EC acquisition and TD attack. Results The literature search yielded a total of 5023 records. Of these, 31 met our inclusion criteria for systematic review and only 17 could be meta-analyzed (9 for TD, and 8 for ESBL-EC). The overall pooled attack rate of TD was 39% (95% confidence interval, CI: 25-53%). In studies where travelers' memory was used to diagnose TD, the pooled attack rate of TD was slightly higher (42%, 95% CI: 21-64%) compared to those where TD was objectively documented (33%, 95% CI: 17-49%). There were significant risks to be colonized with ESBL-EC among the travelers who experienced TD. The pooled rate of ESBL-EC colonization was 72% (CI: 67-78%). Most ESBL-EC produced CTX-M-15 enzyme. Furthermore, most of the travelers who acquired ESBL-EC were from highly industrialized countries recruited from travel clinics: Canada (n = 80), Germany (n = 69), Netherlands (n = 20), Sweden (n = 18), Japan (n = 10), Finland (n = 8), USA (n = 7), Spain (n = 5), and Denmark (n = 3). Conclusions TD pooled attack rate and ESBL-EC acquisition among international travelers visiting India were high in this study. However, we cannot make generalizations based upon this TD pooled attack rate for the current situation, due to a lack of current data. Our study highlights that travelers should be advised on TD to ensure that they do not disregard the risk of contracting TD and be better prepared as a result. It also illustrates the importance of international travel in acquiring antibiotic-resistant Escherichia coli. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=ESBL-EC kn-keyword=ESBL-EC en-keyword=Traveler's diarrhea kn-keyword=Traveler's diarrhea en-keyword=International travelers kn-keyword=International travelers en-keyword=India kn-keyword=India en-keyword=Meta-analysis kn-keyword=Meta-analysis END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=11 article-no= start-page=2095 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211113 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cholera Rapid Diagnostic Tests for the Detection of Vibrio cholerae O1: An Updated Meta-Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=The rapid diagnosis of cholera contributes to adequate outbreak management. This meta-analysis assesses the diagnostic accuracy of cholera rapid tests (RDTs) to detect Vibrio cholerae O1. Methods: Systematic review and meta-analysis. We searched four databases (Medline, EMBASE, Google Scholar, and Web of Science up to 8 September 2021) for studies that evaluated cholera RDTs for the detection of V. cholerae O1 compared with either stool culture or polymerase chain reaction (PCR). We assessed the studies' quality using the QUADAS-2 criteria. In addition, in this update, GRADE approach was used to rate the overall certainty of the evidence. We performed a bivariate random-effects meta-analysis to calculate the pooled sensitivity and specificity of cholera RDTs. Results: Overall, 20 studies were included in this meta-analysis. Studies were from Africa (n = 11), Asia (n = 7), and America (Haiti; n = 2). They evaluated eight RDTs (Crystal VC-O1, Crystal VC, Cholkit, Institut Pasteur cholera dipstick, SD Bioline, Artron, Cholera Smart O1, and Smart II Cholera O1). Using direct specimen testing, sensitivity and specificity of RDTs were 90% (95% CI, 86 to 93) and 86% (95% CI, 81 to 90), respectively. Cholera Sensitivity was higher in studies conducted in Africa [92% (95% CI, 89 to 94)] compared with Asia [82% (95% CI, 77 to 87)]. However, specificity [83% (95% CI, 71 to 91)] was lower in Africa compared with Asia [90% (95% CI, 84 to 94)]. GRADE quality of evidence was estimated as moderate. Conclusions: Against culture or PCR, current cholera RDTs have moderate sensitivity and specificity for detecting Vibrio cholerae O1. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DebnathAnusuya en-aut-sei=Debnath en-aut-mei=Anusuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=rapid test kn-keyword=rapid test en-keyword=cholera kn-keyword=cholera en-keyword=Vibrio cholera O1 kn-keyword=Vibrio cholera O1 en-keyword=sensitivity kn-keyword=sensitivity en-keyword=specificity kn-keyword=specificity en-keyword=accuracy kn-keyword=accuracy en-keyword=update kn-keyword=update END start-ver=1.4 cd-journal=joma no-vol=156 cd-vols= no-issue=22 article-no= start-page=221104 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220614 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Osmotic second virial coefficients for hydrophobic interactions as a function of solute size en-subtitle= kn-subtitle= en-abstract= kn-abstract=To gain quantitative insight into how the overall strength of the hydrophobic interaction varies with the molecular size, we calculate osmotic second virial coefficients B for hydrophobic spherical molecules of different diameters σ in water based on molecular simulation with corrections to the finite-size and finite-concentration effects. It is shown that B (<0) changes by two orders of magnitude greater as σ increases twofold and its solute-size dependence is best fit by a power law B ∝ σ α with the exponent α ≃ 6, which contrasts with the cubic power law that the second virial coefficients of gases obey. It is also found that values of B for the solutes in a nonpolar solvent are positive but they obey the same power law as in water. A thermodynamic identity for B derived earlier [K. Koga, V. Holten, and B. Widom, J. Phys. Chem. B 119, 13391 (2015)] indicates that if B is asymptotically proportional to a power of σ, the exponent α must be equal to or greater than 6. en-copyright= kn-copyright= en-aut-name=NaitoHidefumi en-aut-sei=Naito en-aut-mei=Hidefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkamotoRyuichi en-aut-sei=Okamoto en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SumiTomonari en-aut-sei=Sumi en-aut-mei=Tomonari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=2 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=3 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=1.2テスラオープンMRIを用いた針アーティファクトの特徴および穿刺精度の基礎的検討　 kn-title=Needle artifact characteristics and insertion accuracy using a 1.2 T open MRI scanner: A phantom study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoSoichiro en-aut-sei=Okamoto en-aut-mei=Soichiro kn-aut-name=岡本聡一郎 kn-aut-sei=岡本 kn-aut-mei=聡一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=9 article-no= start-page=5738 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220508 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cholera Outbreaks in India, 2011-2020: A Systematic Review en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fecal contamination of water sources and open defecation have been linked to cholera outbreaks in India. However, a systematic review on the drivers responsible for these outbreaks has yet to be published. Here, we systematically review the published literature on cholera outbreaks in India between 2011 and 2020. We searched studies in English in three databases (MEDLINE, EMBASE, and Web of Science) and the Integrated Disease Surveillance Program that tracks cholera outbreaks throughout India. Two authors independently extracted data and assessed the quality of the included studies. Quantitative data on the modes of transmission reviewed in this study were assessed for any change over time between 2011-2015 and 2016-2020. Our search retrieved 10823 records initially, out of which 81 full-text studies were assessed for eligibility. Among these 81 studies, 20 were eligible for inclusion in this review. There were 565 reported outbreaks between 2011 and 2020 that led to 45,759 cases and 263 deaths. Outbreaks occurred throughout the year; however, they exploded with monsoons (June through September). In Tamil Nadu, a typical peak of cholera outbreaks was observed from December to January. Seventy-two percent (33,089/45,759) of outbreak-related cases were reported in five states, namely Maharashtra, West Bengal, Punjab, Karnataka, and Madhya Pradesh. Analysis of these outbreaks highlighted the main drivers of cholera including contaminated drinking water and food, inadequate sanitation and hygiene (including open defecation), and direct contact between households. The comparison between 2011-2015 and 2016-2020 showed a decreasing trend in the outbreaks that arose due to damaged water pipelines. Many Indians still struggle with open defecation, sanitation, and clean water access. These issues should be addressed critically. In addition, it is essential to interrupt cholera short-cycle transmission (mediated by households, stored drinking water and foodstuffs) during an outbreak. As cholera is associated with deprivation, socio-economic development is the only long-term solution. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DebnathAnusuya en-aut-sei=Debnath en-aut-mei=Anusuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=cholera kn-keyword=cholera en-keyword=outbreak kn-keyword=outbreak en-keyword=water supply kn-keyword=water supply en-keyword=open defecation kn-keyword=open defecation en-keyword=sewage kn-keyword=sewage en-keyword=household kn-keyword=household en-keyword=food kn-keyword=food en-keyword=close contact kn-keyword=close contact en-keyword=behavioral changes kn-keyword=behavioral changes en-keyword=India kn-keyword=India END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue=2 article-no= start-page=025301 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220317 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=High-quality micro-shape fabrication of monocrystalline diamond by nanosecond pulsed laser and acid cleaning en-subtitle= kn-subtitle= en-abstract= kn-abstract=The flat plane of small surface roughness below 0.1 mu m average roughness was obtained for monocrystalline diamond by nanosecond pulsed laser irradiation of 1060 nm and post-process acid cleaning, at a laser fluence around the material removal threshold value. The glossy and flat plane at the bottom of the micro-groove was parallel to the top surface of the specimen, although the round beam of Gaussian mode was irradiated in the direction perpendicular to the top surface of specimen. The square beam of top-hat mode produced a shallower micro-groove with a wider, flatter bottom compared with the round beam in Gaussian mode. The creation method of the flat plane with small surface roughness was discussed in the arrangement strategy of linear micro-grooving by the square beam of top-hat mode. Normal side-by-side repetition of linear micro-grooving did not create a flat plane with constant depth. Therefore, a two-step scanning method was proposed in order to overcome the problem in the normal side-by-side repetition of liner micro-grooving. Non-removal areas were partly retained between the processing lines in the first step, and the laser scanning was conducted on the retained area in the second step. The newly proposed two-step scanning method was practical and useful to create a widely flat plane with small surface roughness, and the two-step scanning method provided superior control over the micro-groove depth. This proposed method can reduce the surface roughness in addition to the shape creation of monocrystalline diamond, and it can be used as a high-quality micro-shape fabrication method of monocrystalline diamond. en-copyright= kn-copyright= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkuboTubasa en-aut-sei=Okubo en-aut-mei=Tubasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KajitaniAtsuya en-aut-sei=Kajitani en-aut-mei=Atsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=monocrystalline diamond kn-keyword=monocrystalline diamond en-keyword=nanosecond pulsed laser kn-keyword=nanosecond pulsed laser en-keyword=flat surface kn-keyword=flat surface en-keyword=smooth surface kn-keyword=smooth surface en-keyword=micro-grooving kn-keyword=micro-grooving END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=6 article-no= start-page=5495 end-page=5501 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of Effective Field-Effect Mobility in Thin-Film and Single-Crystal Transistors for Revisiting Various Phenacene-Type Molecules en-subtitle= kn-subtitle= en-abstract= kn-abstract=The magnitude of the field-effect mobility mu of organic thin-film and single-crystal field-effect transistors (FETs) has been over-estimated in certain recent studies. These reports set alarm bells ringing in the research field of organic electronics. Herein, we report a precise evaluation of the mu values using the effective field-effect mobility, mu(eff), a new indicator that is recently designed to prevent the FET performance of thin-film and single-crystal FETs based on various phenacene molecules from being overestimated. The transfer curves of a range of FETs based on phenacene are carefully categorized on the basis of a previous report. The exact evaluation of the value of mu(eff) depends on the exact classification of each transfer curve. The transfer curves of all our phenacene FETs could be successfully classified based on the method indicated in the aforementioned report, which made it possible to evaluate the exact value of mu(eff) for each FET. The FET performance based on the values of mu(eff) obtained in this study is discussed in detail. In particular, the mu(eff) values of single-crystal FETs are almost consistent with the mu values that were reported previously, but the mu(eff) values of thin-film FETs were much lower than those previously reported for mu, owing to a high absolute threshold voltage, vertical bar V-th vertical bar. The increase in the field-effect mobility as a function of the number of benzene rings, which was previously demonstrated based on the mu values of single-crystal FETs with phenacene molecules, is well reproduced from the mu(eff) values. The FET performance is discussed based on the newly evaluated mu(eff) values, and the future prospects of using phenacene molecules in FET devices are demonstrated. en-copyright= kn-copyright= en-aut-name=ZhangYanting en-aut-sei=Zhang en-aut-mei=Yanting kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EguchiRitsuko en-aut-sei=Eguchi en-aut-mei=Ritsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamaoShino en-aut-sei=Hamao en-aut-mei=Shino kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GotoHidenori en-aut-sei=Goto en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=2 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Chemistry, Okayama University kn-affil= affil-num=5 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=6 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=46 article-no= start-page=12820 end-page=12831 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Theory of Gas Solubility and Hydrophobic Interaction in Aqueous Electrolyte Solutions en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ion-specific effects on the solubility of nonpolar solutes and on the solute–solute hydrophobic interaction in aqueous electrolyte solutions are studied on the basis of a continuum theory that incorporates the excluded volume of the molecules using the four-component (water, cations, anions, and solutes) Boublı́k–Mansoori–Carnahan–Starling–Leland model and ion hydration (electrostriction) using the Born model. We examine how the ordering of ions in the salt effect on the solubility as measured by the Sechenov coefficient KS changes with varying sizes of ions and solutes. Our calculation reproduces the general trend of experimentally measured KS and also provides insight into the irregular behavior of KS for lithium ion. The correlation between KS and the salt effect on the hydrophobic interaction that has been pointed out earlier is accounted for by an explicit connection between KS and the salt-enhanced-association coefficient CI in the expansion of the second osmotic virial coefficient B(ns) = B(0) – CIns + ··· in powers of the salt density ns at fixed pressure and temperature. The quadratic relation is derived for ions and solutes that are not very large. en-copyright= kn-copyright= en-aut-name=OkamotoRyuichi en-aut-sei=Okamoto en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=2 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=胃腺腫：長期間の経過観察中に高率に癌の発生、異時性胃癌発生のリスクを伴う kn-title=Gastric Adenoma: A High Incidence Rate of Developing Carcinoma and Risk of Metachronous Gastric Cancer according to Long-Term Follow-Up en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoYuki en-aut-sei=Okamoto en-aut-mei=Yuki kn-aut-name=岡本雄貴 kn-aut-sei=岡本 kn-aut-mei=雄貴 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=2 article-no= start-page=109 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Formation and Its Mechanism of High-speed Micro-grooving on Metal Surface by Angled CW Laser Irradiation en-subtitle= kn-subtitle= en-abstract= kn-abstract=In general, pulsed lasers with high peak power have been used for the micro-groove formation. However, the processing speed is limited by the pulse repetition rate. On the other hand, CW laser can be expected to perform the high-speed processing by continuous energy input. The mechanism of micro-groove formation by CW laser was investigated by high-speed observation and the thermal fluid analysis. In the perpendicular irradiation of CW laser, the molten metal flows symmetrically around the keyhole to the backward direction, and micro-grooves remain at both edges of molten region. In contrast, in the angled irradiation, the molten metal at the reflection-side scatters as spatters. The remained molten metal flows from the reflection-side to the incident-side through the bottom of keyhole, since the recoil pressure is generated from the reflection-side to the incident-side. In addition, high-speed scanning contributes to keeping the sufficient time and force to move the molten metal in the backward direction. Then, the micro-groove remains at the reflection-side, while the upheaval is formed at the incident-side by gathering the molten metal from the reflection-side and the front of keyhole. Asymmetrical behavior of molten metal flow in angled irradiation of CW laser can create micro-groove in the reflection-side. en-copyright= kn-copyright= en-aut-name=TauraNozomi en-aut-sei=Taura en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MitsunobuAkiya en-aut-sei=Mitsunobu en-aut-mei=Akiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakaiTatsuhiko en-aut-sei=Sakai en-aut-mei=Tatsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University, Japan kn-affil= affil-num=2 en-affil=Faculty of Engineering, Okayama University, Japan kn-affil= affil-num=3 en-affil=NIPPON STEEL CORPORATION, Japan kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University, Japan kn-affil= affil-num=5 en-affil=Graduate School of Natural Science and Technology, Okayama University, Japan kn-affil= en-keyword=CW laser kn-keyword=CW laser en-keyword=micro-groove kn-keyword=micro-groove en-keyword=high-speed scanning kn-keyword=high-speed scanning en-keyword=thermal fluid analysis kn-keyword=thermal fluid analysis en-keyword=high-speed observation kn-keyword=high-speed observation END start-ver=1.4 cd-journal=joma no-vol=299 cd-vols= no-issue= article-no= start-page=117388 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Superposition of 532 nm and 1064 nm Wavelengths in Copper Micro-welding by Pulsed Nd:YAG Laser en-subtitle= kn-subtitle= en-abstract= kn-abstract=Unstable and low absorption of laser energy is experienced in copper welding at around 1000 nm wavelength. At 532 nm wavelength, there is stable and high laser absorption by copper. Past researches have shown that transitional processing condition between keyhole and heat conduction welding results in a stable micro-welding process characterized by good surface quality and deep penetration. In order to adapt laser welding to copper using pulsed Nd:YAG lasers, investigations of welding quality and efficiency were addressed. Processing was done under transitional processing condition between heat conduction and keyhole welding. Copper C1020 specimens were processed using superposed laser wavelengths of 1064 nm and 532 nm. Effects of irradiation delay and power density on the process were clarified by taking measurements of absorption rates and molten volumes, and by analyzing the weld beads. In addition, the dynamics of molten area and keyhole formation were investigated through three-dimensional FEM analysis. A stabilized laser absorption and increased molten volume was achieved by superposition using 532 nm laser of an appropriate high power density coupled with a short irradiation delay for the 1064 nm laser, which resulted in high-efficiency welding of copper. en-copyright= kn-copyright= en-aut-name=MainaMartin Ruthandi en-aut-sei=Maina en-aut-mei=Martin Ruthandi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamadaKazuki en-aut-sei=Hamada en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakashibaShin-ichi en-aut-sei=Nakashiba en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NishiNorio en-aut-sei=Nishi en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Nontraditional Machining Laboratory, Okayama University kn-affil= affil-num=2 en-affil=Nontraditional Machining Laboratory, Okayama University kn-affil= affil-num=3 en-affil=Nontraditional Machining Laboratory, Okayama University kn-affil= affil-num=4 en-affil=Nontraditional Machining Laboratory, Okayama University kn-affil= affil-num=5 en-affil=Kataoka Corporation kn-affil= affil-num=6 en-affil=Kataoka Corporation kn-affil= END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=726273 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210820 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Virulence of Cholera Toxin Gene-Positive Vibrio cholerae Non-O1/non-O139 Strains Isolated From Environmental Water in Kolkata, India en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cholera toxin (CT)-producing Vibrio cholerae O1 and O139 cause acute diarrheal disease and are proven etiological agents of cholera epidemics and pandemics. On the other hand, V. cholerae non-O1/non-O139 are designated as non-agglutinable (NAG) vibrios and are not associated with epidemic cholera. The majority of NAG vibrios do not possess the gene for CT (ctx). In this study, we isolated three NAG strains (strains No. 1, 2, and 3) with ctx from pond water in Kolkata, India, and examined their pathogenic properties. The enterotoxicity of the three NAG strains in vivo was examined using the rabbit ileal intestinal loop test. Strain No. 1 induced the accumulation of fluid in the loop, and the volume of fluid was reduced by simultaneous administration of anti-CT antiserum into the loop. The volume of fluid in the loop caused by strains No. 2 and 3 was small and undetectable, respectively. Then, we cultured these three strains in liquid medium in vitro at two temperatures, 25 degrees C and 37 degrees C, and examined the amount of CT accumulated in the culture supernatant. CT was accumulated in the culture supernatant of strain No.1 when the strain was cultured at 25 degrees C, but that was low when cultured at 37 degrees C. The CT amount accumulated in the culture supernatants of the No. 2 and No. 3 strains was extremely low at both temperature under culture conditions examined. In order to clarify the virulence properties of these strains, genome sequences of the three strains were analyzed. The analysis showed that there was no noticeable difference among three isolates both in the genes for virulence factors and regulatory genes of ctx. However, vibrio seventh pandemic island-II (VSP-II) was retained in strain No. 1, but not in strains No. 2 or 3. Furthermore, it was revealed that the genotype of the B subunit of CT in strain No. 1 was type 1 and those of strains No. 2 and 3 were type 8. Histopathological examination showed the disappearance of villi in intestinal tissue exposed to strain No. 1. In addition, fluid accumulated in the loop due to the action of strain No. 1 had hemolytic activity. This indicated that strain No. 1 may possesses virulence factors to induce severe syndrome when the strain infects humans, and that some strains of NAG vibrio inhabiting pond water in Kolkata have already acquired virulence, which can cause illness in humans. There is a possibility that these virulent NAG vibrios, which have acquired genes encoding factors involved in virulence of V. cholerae O1, may emerge in various parts of the world and cause epidemics in the future. en-copyright= kn-copyright= en-aut-name=TakahashiEizo en-aut-sei=Takahashi en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OchiSadayuki en-aut-sei=Ochi en-aut-mei=Sadayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MizunoTamaki en-aut-sei=Mizuno en-aut-mei=Tamaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoritaDaichi en-aut-sei=Morita en-aut-mei=Daichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoritaMasatomo en-aut-sei=Morita en-aut-mei=Masatomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OhnishiMakoto en-aut-sei=Ohnishi en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KoleyHemanta en-aut-sei=Koley en-aut-mei=Hemanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=DuttaMoumita en-aut-sei=Dutta en-aut-mei=Moumita kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ChowdhuryGoutam en-aut-sei=Chowdhury en-aut-mei=Goutam kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MukhopadhyayAsish K. en-aut-sei=Mukhopadhyay en-aut-mei=Asish K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=DuttaShanta en-aut-sei=Dutta en-aut-mei=Shanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=2 en-affil=Department of Health Pharmacy, Yokohama University of Pharmacy kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= affil-num=4 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=5 en-affil=Department of Bacteriology I, National Institute of Infectious Diseases kn-affil= affil-num=6 en-affil=Department of Bacteriology I, National Institute of Infectious Diseases kn-affil= affil-num=7 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=8 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=9 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=10 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=11 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=12 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= affil-num=13 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= en-keyword=Vibrio cholerae kn-keyword=Vibrio cholerae en-keyword=NAG Vibrio kn-keyword=NAG Vibrio en-keyword=cholera toxin kn-keyword=cholera toxin en-keyword=virulence kn-keyword=virulence en-keyword=environmental water kn-keyword=environmental water en-keyword=gene analysis kn-keyword=gene analysis END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue= article-no= start-page=1 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=John Toland and the Invention of Pantheism: A Successor of Giordano Bruno’s Philosophy kn-title=ジョン・トーランドによる汎神論の発明 : ジョルダーノ・ブルーノの哲学の継承 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKAMOTOGenta en-aut-sei=OKAMOTO en-aut-mei=Genta kn-aut-name=岡本源太 kn-aut-sei=岡本 kn-aut-mei=源太 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院社会文化科学研究科 END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=102 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=2020 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies. Previous studies, using a pentylenetetrazole (PTZ)-induced kindling mouse model, showed that astrocyte activation and an increase in perineuronal nets (PNNs) and extracellular matrix (ECM) molecules occurred within the hippocampus. However, the mechanisms of initiation and suppression of these changes, remain unclear.
Herein, we analyzed the attenuation of astrocyte activation caused by dizocilpine (MK-801) administration, as well as the anticonvulsant effect of α-pinene on seizures and production of ECM molecules. Our results showed that MK-801 significantly reduced kindling acquisition, while α-pinene treatment prevented an increase in seizures incidences. Both MK-801 and α-pinene administration attenuated astrocyte activation by PTZ and significantly attenuated the increase in ECM molecules.
Our results indicate that astrocyte activation and an increase in ECM may contribute to epileptogenesis and suggest that MK-801 and α-pinene may prevent epileptic seizures by suppressing astrocyte activation and ECM molecule production. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimadaAtsumi en-aut-sei=Shimada en-aut-mei=Atsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MurakamiShinji en-aut-sei=Murakami en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KitamuraNaoya en-aut-sei=Kitamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WaniKenta en-aut-sei=Wani en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakahashiYu en-aut-sei=Takahashi en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IshiharaTakeshi en-aut-sei=Ishihara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare kn-affil= affil-num=2 en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College kn-affil= affil-num=3 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=7 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=8 en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= en-keyword=Epilepsy kn-keyword=Epilepsy en-keyword=Kindling kn-keyword=Kindling en-keyword=Pentylenetetrazol kn-keyword=Pentylenetetrazol en-keyword=Perineuronal nets kn-keyword=Perineuronal nets en-keyword=Wisteria floribunda kn-keyword=Wisteria floribunda END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=52 article-no= start-page=31547 end-page=31552 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200826 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Facile synthesis of picenes incorporating imide moieties at both edges of the molecule and their application to n-channel field-effect transistors en-subtitle= kn-subtitle= en-abstract= kn-abstract=Picene derivatives incorporating imide moieties along the long-axis direction of the picene core (Cn-PicDIs) were conveniently synthesized through a four-step synthesis. Photochemical cyclization of dinaphthylethenes was used as the key step for constructing the picene skeleton. Field-effect transistor (FET) devices of Cn-PicDIs were fabricated by using ZrO2 as a gate substrate and their FET characteristics were investigated. The FET devices showed normally-off n-channel operation; the averaged electron mobility (μ) was evaluated to be 2(1) × 10−4, 1.0(6) × 10−1 and 1.4(3) × 10−2 cm2 V−1 s−1 for C4-PicDI, C8-PicDI and C12-PicDI, respectively. The maximum μ value as high as 2.0 × 10−1 cm2 V−1 s−1 was observed for C8-PicDI. The electronic spectra of Cn-PicDIs in solution showed the same profiles irrespective of the alkyl chain lengths. In contrast, in thin films, the UV absorption and photoelectron yield spectroscopy (PYS) indicated that the lowest unoccupied molecular orbital (LUMO) level of Cn-PicDIs gradually lowered upon the elongation of the alkyl chains, suggesting that the alkyl chains modify intermolecular interactions between the Cn-PicDI molecules in thin films. The present results provide a new strategy for constructing a high performance n-channel organic semiconductor material by utilizing the electronic features of phenacenes. en-copyright= kn-copyright= en-aut-name=GuoYuxin en-aut-sei=Guo en-aut-mei=Yuxin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshiokaKaito en-aut-sei=Yoshioka en-aut-mei=Kaito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamaoShino en-aut-sei=Hamao en-aut-mei=Shino kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=5 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=6 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=7 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=8 article-no= start-page=1288 end-page=1291 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Low Viability of Cholera Toxin-Producing Vibrio cholerae O1 in the Artificial Low Ionic Strength Aquatic Solution en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has been well known that Vibrio cholerae inhabit in environmental water. As many patients infected with cholera toxin-producing V. cholerae O1 (toxigenic V. cholerae O1) emerge in Kolkata, India, it has been thought that toxigenic V. cholerae O1 is easily detected in environmental water in Kolkata. However, we could not isolate toxigenic V. cholerae O1 from environmental water in Kolkata, though NAG Vibrio (generic name of V. cholerae non-O1/non-O139) is constantly detected. To clear the reason for the non-isolation of toxigenic V. cholerae O1, we examined the viability of V. cholera O1 and NAG Vibrios in the artificial low ionic strength aquatic solution. We found that the viability of toxigenic V. cholerae O1 in the solution is low, but that of NAG Vibrios is high. Subsequently, we examined the viability of NAG Vibrios possessing cholera toxin gene (ctx) in the same condition and found that the viability of these NAG Vibrios is low. These results indicate that the existence of ctx in V. cholerae affects the viability of V. cholerae in the aquatic solution used in this experiment. We thought that there was closely relation between the low viability of toxigenic V. cholerae O1 in the artificial low ionic strength aquatic solution and the low frequency of isolation of the strain from environmental water. en-copyright= kn-copyright= en-aut-name=PaulSubha Sankar en-aut-sei=Paul en-aut-mei=Subha Sankar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiEizo en-aut-sei=Takahashi en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ChowdhuryGoutam en-aut-sei=Chowdhury en-aut-mei=Goutam kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MizunoTamaki en-aut-sei=Mizuno en-aut-mei=Tamaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MukhopadhyayAsish K. en-aut-sei=Mukhopadhyay en-aut-mei=Asish K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=DuttaShanta en-aut-sei=Dutta en-aut-mei=Shanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=2 en-affil=Department of Health Pharmacy, Yokohama University of Pharmacy kn-affil= affil-num=3 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= affil-num=6 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=7 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=8 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= en-keyword=Vibrio cholerae kn-keyword=Vibrio cholerae en-keyword=cholera toxin kn-keyword=cholera toxin en-keyword=aquatic solution kn-keyword=aquatic solution en-keyword=viability kn-keyword=viability END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=6 article-no= start-page=937 end-page=947 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200313 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of numerical aperture on molten area characteristics in micro-joining of glass by picosecond pulsed laser en-subtitle= kn-subtitle= en-abstract= kn-abstract=Glass products with precise and sophisticated shapes are highly demanded in the field of MEMS due to their excellent properties. Ultrashort pulsed laser has been expected to be a powerful and reliable tool for micro-welding of glass. Focusing condition such as numerical aperture (N.A.) is a critical parameter that controls how ultrashort laser pulses interact with and propagate in glass, and it has a great influence on the laser micro-welding characteristics of glass. In order to investigate the quality of welding process, it is important to understand the dependence of the mechanical strength of molten area created in glass specimen with various numerical apertures. Therefore, the mechanical strength of molten area with various numerical apertures was evaluated in micro-welding of glass by picosecond pulsed laser. Higher bending strength could be obtained under an appropriate volume ratio of molten area and glass specimen, when continuous molten areas were formed. In addition, high density and large size of molten area without crack led to higher breaking stress. It is concluded that superior focusing characteristics such as N.A. 0.65 enable a long region of high power density in beam axis, which can satisfy both high mechanical strength and high processing speed. en-copyright= kn-copyright= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OuyangZhiyong en-aut-sei=Ouyang en-aut-mei=Zhiyong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraTakumi en-aut-sei=Fujiwara en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Picosecond pulsed laser kn-keyword=Picosecond pulsed laser en-keyword=Glass material kn-keyword=Glass material en-keyword=Numerical aperture kn-keyword=Numerical aperture en-keyword=Bending strength kn-keyword=Bending strength en-keyword=Breaking stress kn-keyword=Breaking stress END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=22 article-no= start-page=7422 end-page=7435 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200418 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of [7]phenacene incorporating tetradecyl chains in the axis positions and its application in field-effect transistors en-subtitle= kn-subtitle= en-abstract= kn-abstract=Field-effect transistors (FETs) were fabricated using a new type of phenacene molecule, 3,12-ditetradecyl[7]phenacene ((C14H29)2-[7]phenacene), and solid gate dielectrics or an electric double layer (EDL) capacitor with an ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate (bmim[PF6])). The new molecule, (C14H29)2-[7]phenacene, was efficiently synthesized via the Mallory photoreaction. Its crystal structure and electronic properties were determined, using X-ray diffraction, scanning tunneling microscopy/spectroscopy (STM and STS), absorption spectroscopy, and photoelectron yield spectroscopy, which showed a monoclinic crystal lattice (space group P21 (no. 4)) and an energy gap of ∼3.0 eV. The STM image clearly showed the molecular structure of (C14H29)2-[7]phenacene, as well as the closed molecular stacking, indicative of a strong fastener effect between alkyl chains. The X-ray diffraction pattern of thin films of (C14H29)2-[7]phenacene formed on a SiO2/Si substrate suggested that the molecule stood on the surface with an inclined angle of 30° with respect to the normal axis of the surface. The FET properties were recorded in two-terminal measurement mode, showing p-channel normally-off characteristics. The averaged values of field-effect mobility, μ, were 1.6(3) cm2 V−1 s−1 for a (C14H29)2-[7]phenacene thin-film FET with a SiO2 gate dielectric and 6(4) × 10−1 cm2 V−1 s−1 for a (C14H29)2-[7]phenacene thin-film EDL FET with bmim[PF6]. Thus, higher FET performance was obtained with an FET using a thin film of (C14H29)2-[7]phenacene compared to parent [7]phenacene. This study could pioneer an avenue for the realization of high-performance FETs through the addition of alkyl chains to phenacene molecules. en-copyright= kn-copyright= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HamaoShino en-aut-sei=Hamao en-aut-mei=Shino kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KozasaKeiko en-aut-sei=Kozasa en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WangYanan en-aut-sei=Wang en-aut-mei=Yanan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=PanYong-He en-aut-sei=Pan en-aut-mei=Yong-He kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YenYu-Hsiang en-aut-sei=Yen en-aut-mei=Yu-Hsiang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HoffmannGermar en-aut-sei=Hoffmann en-aut-mei=Germar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=5 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=6 en-affil=Department of Physics & Center for Quantum Technology, National Tsing Hua University kn-affil= affil-num=7 en-affil=Department of Physics & Center for Quantum Technology, National Tsing Hua University kn-affil= affil-num=8 en-affil=Department of Physics & Center for Quantum Technology, National Tsing Hua University kn-affil= affil-num=9 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=10 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=6 article-no= start-page=435 end-page=444 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Genomic characterization of antibiotic resistance‐encoding genes in clinical isolates of Vibrio cholerae non‐O1/non‐O139 strains from Kolkata, India: generation of novel types of genomic islands containing plural antibiotic resistance genes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Non‐O1/non‐O139 nontoxigenic Vibrio cholerae associated with cholera‐like diarrhea has been reported in Kolkata, India. However, the property involved in the pathogenicity of these strains has remained unclear. The character of 25 non‐O1/non‐O139 nontoxigenic V. cholerae isolated during 8 years from 2007 to 2014 in Kolkata was examined. Determination of the serogroup showed that the serogroups O6, O10, O35, O36, O39, and O70 were represented by two strains in each serogroup, and the remaining isolates belonged to different serogroups. To clarify the character of antibiotic resistance of these isolates, an antibiotic resistance test and the gene analysis were performed. According to antimicrobial drug susceptibility testing, 13 strains were classified as drug resistant. Among them, 10 strains were quinolone resistant and 6 of the 13 strains were resistant to more than three antibiotics. To define the genetic background of the antibiotic character of these strains, whole‐genome sequences of these strains were determined. From the analysis of these sequences, it becomes clear that all quinolone resistance isolates have mutations in quinolone resistance‐determining regions. Further research on the genome sequence showed that four strains possess Class 1 integrons in their genomes, and that three of the four integrons are found to be located in their genomic islands. These genomic islands are novel types. This indicates that various integrons containing drug resistance genes are spreading among V. cholerae non‐O1/non‐O139 strains through the action of newly generated genomic islands. en-copyright= kn-copyright= en-aut-name=MoritaDaichi en-aut-sei=Morita en-aut-mei=Daichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiEizo en-aut-sei=Takahashi en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoritaMasatomo en-aut-sei=Morita en-aut-mei=Masatomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhnishiMakoto en-aut-sei=Ohnishi en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MizunoTamaki en-aut-sei=Mizuno en-aut-mei=Tamaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=Miyoshi Shin‐ichi en-aut-sei=Miyoshi en-aut-mei= Shin‐ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=DuttaDevarati en-aut-sei=Dutta en-aut-mei=Devarati kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=RamamurthyThandavarayan en-aut-sei=Ramamurthy en-aut-mei=Thandavarayan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ChowdhuryGoutam en-aut-sei=Chowdhury en-aut-mei=Goutam kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=Mukhopadhyay Asish K. en-aut-sei=Mukhopadhyay en-aut-mei= Asish K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India, Okayama University kn-affil= affil-num=2 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India, Okayama University kn-affil= affil-num=3 en-affil=Department of Bacteriology I, National Institute of Infectious Diseases kn-affil= affil-num=4 en-affil=Department of Bacteriology I, National Institute of Infectious Diseases kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases kn-affil= affil-num=8 en-affil=Center for Human Microbial Ecology, Translational Health Science and Technology Institute kn-affil= affil-num=9 en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases kn-affil= affil-num=10 en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases kn-affil= affil-num=11 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India, Okayama University kn-affil= en-keyword=antibiotic resistance kn-keyword=antibiotic resistance en-keyword=diarrhea kn-keyword=diarrhea en-keyword=genome sequence kn-keyword=genome sequence en-keyword=genomic island kn-keyword=genomic island en-keyword=integron kn-keyword=integron en-keyword=Vibrio cholerae kn-keyword=Vibrio cholerae END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=コラーゲン結合型塩基性線維芽細胞増殖因子はその高い組織内滞留性によって効率的に歯周組織再生を促進する en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoKentaro en-aut-sei=Okamoto en-aut-mei=Kentaro kn-aut-name=岡本憲太郎 kn-aut-sei=岡本 kn-aut-mei=憲太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=岡山大学大学院医歯薬学総合研究科 END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=2-3 article-no= start-page=123 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200319 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Silver Democracy and Electoral System : Political Feasibility of Policy Reform Plans in an Aging Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Humanities and Social Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=5817 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201949 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Helping-Like Behaviour in Mice Towards Conspecifics Constrained Inside Tubes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Prosocial behaviour, including helping behaviour, benefits others. Recently, helping-like behaviour has been observed in rats, but whether it is oriented towards rescue, social contact with others, or other goals remains unclear. Therefore, we investigated whether helping-like behaviour could be observed in mice similar to that in rats. Because mice are social animals widely used in neuroscience, the discovery of helping-like behaviour in mice would be valuable in clarifying the psychological and biological mechanisms underlying pro-sociability. We constrained mice inside tubes. Subject mice were allowed to move freely in cages with tubes containing constrained conspecifics. The subject mice released both cagemates and stranger mice but did not engage in opening empty tubes. Furthermore, the same behaviour was observed under aversive conditions and with anesthetised conspecifics. Interestingly, hungry mice opened the tubes containing food before engaging in tube-opening behaviour to free constrained conspecifics. Mice showed equal preferences for constrained and freely moving conspecifics. We demonstrated for the first time that mice show tube-opening behaviour. Furthermore, we partly clarified the purpose and motivation of this behaviour. An effective mouse model for helping-like behaviour would facilitate research on the mechanisms underlying prosocial behaviour. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MurakamiShinji en-aut-sei=Murakami en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitamuraNaoya en-aut-sei=Kitamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WaniKenta en-aut-sei=Wani en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IshiharaTakeshi en-aut-sei=Ishihara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=3 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=4009 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201938 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of the extended phenacene molecules, [10]phenacene and [11]phenacene, and their performance in a field-effect transistor en-subtitle= kn-subtitle= en-abstract= kn-abstract= The [10]phenacene and [11]phenacene molecules have been synthesized using a simple repetition of Wittig reactions followed by photocyclization. Sufficient amounts of [10]phenacene and [11]phenacene were obtained, and thin-film FETs using these molecules have been fabricated with SiO2 and ionic liquid gate dielectrics. These FETs operated in p-channel. The averaged measurements of field-effect mobility, <μ>, were 3.1(7) × 10-2 and 1.11(4) × 10-1 cm2 V-1 s-1, respectively, for [10]phenacene and [11]phenacene thin-film FETs with SiO2 gate dielectrics. Furthermore, [10]phenacene and [11]phenacene thin-film electric-double-layer (EDL) FETs with ionic liquid showed low-voltage p-channel FET properties, with <μ> values of 3(1) and 1(1) cm2 V-1 s-1, respectively. This study also discusses the future utility of the extremely extended π-network molecules [10]phenacene and [11]phenacene as the active layer of FET devices, based on the experimental results obtained. en-copyright= kn-copyright= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HamaoShino en-aut-sei=Hamao en-aut-mei=Shino kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=EguchiRitsuko en-aut-sei=Eguchi en-aut-mei=Ritsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotoHidenori en-aut-sei=Goto en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakabayashiYasuhiro en-aut-sei=Takabayashi en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YenPaul Yu-Hsiang en-aut-sei=Yen en-aut-mei=Paul Yu-Hsiang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=LiangLuo Uei en-aut-sei=Liang en-aut-mei=Luo Uei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ChouChia-Wei en-aut-sei=Chou en-aut-mei=Chia-Wei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HoffmannGermar en-aut-sei=Hoffmann en-aut-mei=Germar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=GohdaShin en-aut-sei=Gohda en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SuginoHisako en-aut-sei=Sugino en-aut-mei=Hisako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=LiaosYen-Fa en-aut-sei=Liaos en-aut-mei=Yen-Fa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IshiiHirofumi en-aut-sei=Ishii en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil= Department of Chemistry, Okayama University kn-affil= affil-num=2 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=5 en-affil= Department of Chemistry, Okayama University kn-affil= affil-num=6 en-affil=Department of Physics, National Tsing Hua University kn-affil= affil-num=7 en-affil=Department of Physics, National Tsing Hua University kn-affil= affil-num=8 en-affil=Department of Physics, National Tsing Hua University kn-affil= affil-num=9 en-affil=Department of Physics, National Tsing Hua University kn-affil= affil-num=10 en-affil=NARD Co Ltd kn-affil= affil-num=11 en-affil=NARD Co Ltd kn-affil= affil-num=12 en-affil=National Synchrotron Radiation Center kn-affil= affil-num=13 en-affil=National Synchrotron Radiation Center kn-affil= affil-num=14 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=7 article-no= start-page=1412 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190303 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Influence of Numerical Aperture on Molten Area Formation in Fusion Micro-Welding of Glass by Picosecond Pulsed Laser en-subtitle= kn-subtitle= en-abstract= kn-abstract= Focusing condition such as numerical aperture (N.A.) has a great influence on the creation of molten area and the stable welding process in fusion micro-welding of glass. In this study, a picosecond pulsed laser of 1064 nm in wavelength and 12.5 ps in pulse duration was tightly focused inside a borosilicate glass using objective lenses of numerical apertures 0.45, 0.65, and 0.85 with spherical aberration correction. Influence of numerical aperture on molten area formation was experimentally investigated through analysis of focusing situation in glass, and movement of absorption point, and then molten area characteristics were discussed. It is concluded that N.A. of 0.65 with superior focusing characteristics can form a large and continuous molten area without cracks, which enables achievement of stable joining of glass material by picosecond pulsed laser. en-copyright= kn-copyright= en-aut-name=OuyangZhiyong en-aut-sei=Ouyang en-aut-mei=Zhiyong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OginoYuta en-aut-sei=Ogino en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakagawaTomokazu en-aut-sei=Sakagawa en-aut-mei=Tomokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil= kn-affil= affil-num=5 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=ultrashort pulsed laser kn-keyword=ultrashort pulsed laser en-keyword=glass material kn-keyword=glass material en-keyword=absorption point kn-keyword=absorption point en-keyword=molten area kn-keyword=molten area en-keyword=numerical aperture kn-keyword=numerical aperture END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=43 article-no= start-page=151189 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Fluorescence properties of amido-substituted 2,3-naphthalimides: Excited-state intramolecular proton transfer (ESIPT) fluorescence and responses to Ca2+ ions en-subtitle= kn-subtitle= en-abstract= kn-abstract= 2,3-Naphthalimide derivatives incorporating trifluoroacetamido (3a) and methansulfonamido (3b) functionalities at the 1-position were prepared and their intramolecular excited state proton transfer (ESIPT) fluorescence and responses to metal ions were investigated. Compound 3a displayed normal fluorescence in the amide form in toluene and MeCN and no response to metal cations in the corresponding amidate ion form. In contrast, compound 3b gave off dual emission assignable to normal and ESIPT fluorescence. Additionally, the amidate form of compound 3b displayed off-on fluorescence response to Ca2+. en-copyright= kn-copyright= en-aut-name=WangLei en-aut-sei=Wang en-aut-mei=Lei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiiMayu en-aut-sei=Fujii en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NambaMisa en-aut-sei=Namba en-aut-mei=Misa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=5 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Fluorescence kn-keyword=Fluorescence en-keyword=ESIPT kn-keyword=ESIPT en-keyword=Naphthalimide kn-keyword=Naphthalimide en-keyword=Ca2+ probe kn-keyword=Ca2+ probe END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue= article-no= start-page=108879 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comprehensive behavioral study of the effects of vanillin inhalation in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Vanillin is widely used in food and cosmetics, among other substances, for its sweet smell. However, the neuropsychological effects of vanillin inhalation have not been elucidated. In this study, we investigated the effect of vanillin inhalation on mouse behavior. First, we investigated whether the aroma of vanillin was attractive or repulsive for mice. Thereafter, the mice inhaled vanillin for 20 min before each test in a series of behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, cotton bud biting, and Porsolt forced swim tests). In these tests, the mice showed a neutral response to vanillin. Mice that inhaled vanillin had a suppressed pain response in the hot plate test. In addition, the grip strength of the forelimbs of mice that inhaled vanillin was decreased. No significant differences were found between the mice inhaling vanillin and control mice in the open field, Y-maze, tail suspension, forced swimming, and aggression tests. These results show that vanillin inhalation has anti-nociceptive effects, similar to other routes of administration. The results also show that vanillin inhalation does not cause significant behavioral effects. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimadaAtsumi en-aut-sei=Shimada en-aut-mei=Atsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MurakamiShinji en-aut-sei=Murakami en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KitamuraNaoya en-aut-sei=Kitamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WaniKenta en-aut-sei=Wani en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakahashiYu en-aut-sei=Takahashi en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FujiwaraYuko en-aut-sei=Fujiwara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IshiharaTakeshi en-aut-sei=Ishihara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare kn-affil= affil-num=2 en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College kn-affil= affil-num=3 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=7 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=8 en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Health and Sports Science, Kawasaki University of Medical Welfare kn-affil= affil-num=11 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= en-keyword=Anti-nociceptive kn-keyword=Anti-nociceptive en-keyword=Vanillin kn-keyword=Vanillin en-keyword=Essential oil kn-keyword=Essential oil en-keyword=Inhalation kn-keyword=Inhalation en-keyword=Analgesia kn-keyword=Analgesia END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=1 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform cortices en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the developing central nervous system (CNS), extracellular matrix (ECM) molecules have regulating roles such as in brain development, neural-circuit maturation, and synaptic-function control. However, excluding the perineuronal net (PNN) area, the distribution, constituent elements, and expression level of granular ECM molecules (diffuse ECM) present in the mature CNS remain unclear. Diffuse ECM molecules in the CNS share the components of PNNs and are likely functional. As cortical functions are greatly region-dependent, we hypothesized that ECM molecules would differ in distribution, expression level, and components in a region- and layer-dependent manner. We examined the layer-specific expression of several chondroitin sulfate proteoglycans (aggrecan, neurocan, and brevican), tenascin-R, Wisteria floribunda agglutinin (WFA)-positive molecules, hyaluronic acid, and link protein in the somatosensory and piriform cortices of mature mice. Furthermore, we investigated expression changes in WFA-positive molecules due to aging. In the somatosensory cortex, PNN density was particularly high at layer 4 (L4), but not all diffuse ECM molecules were highly expressed at L4 compared to the other layers. There was almost no change in tenascin-R and hyaluronic acid in any somatosensory-cortex layer. Neurocan showed high expression in L1 of the somatosensory cortex. In the piriform cortex, many ECM molecules showed higher expression in L1 than in the other layers. However, hyaluronic acid showed high expression in deep layers. Here, we clarified that ECM molecules differ in constituent elements and expression in a region- and layer-dependent manner. Region-specific expression of ECM molecules is possibly related to functions such as region-specific plasticity and vulnerability. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MurakamiShinji en-aut-sei=Murakami en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitamuraNaoya en-aut-sei=Kitamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WaniKenta en-aut-sei=Wani en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IshiharaTakeshi en-aut-sei=Ishihara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare kn-affil= affil-num=2 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=3 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= en-keyword=Extracellular matrix kn-keyword=Extracellular matrix en-keyword=Perineuronal nets kn-keyword=Perineuronal nets en-keyword=Piriform cortex kn-keyword=Piriform cortex en-keyword=Proteoglycans kn-keyword=Proteoglycans en-keyword=Somatosensory cortex kn-keyword=Somatosensory cortex en-keyword=Wisteria floribunda kn-keyword=Wisteria floribunda END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue=6 article-no= start-page=e01945 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimadaAtsumi en-aut-sei=Shimada en-aut-mei=Atsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MurakamiShinji en-aut-sei=Murakami en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KitamuraNaoya en-aut-sei=Kitamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WaniKenta en-aut-sei=Wani en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiwaraYuko en-aut-sei=Fujiwara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IshiharaTakeshi en-aut-sei=Ishihara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare kn-affil= affil-num=2 en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College kn-affil= affil-num=3 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=7 en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Health and Sports Science, Kawasaki University of Medical Welfare kn-affil= affil-num=10 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= en-keyword=Neuroscience kn-keyword=Neuroscience en-keyword=Physiology kn-keyword=Physiology END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1 article-no= start-page=197 end-page=200 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=High surface quality micro machining of monocrystalline diamond by picosecond pulsed laser en-subtitle= kn-subtitle= en-abstract= kn-abstract=In micro machining of monocrystalline diamond by pulsed laser, unique processing characteristics appeared only under a few ten picosecond pulse duration and a certain overlap rate of laser shot. Cracks mostly propagate in parallel direction to top surface of workpiece, although the laser beam axis is perpendicular to the surface. This processed area can keep diamond structure, and its surface roughness is smaller than R-a = 0.2 mu M. New laser micro machining method to keep diamond structure and small surface roughness is proposed. This method can contribute to reduce the polishing process in micro machining of diamond. (C) 2019 Published by Elsevier Ltd on behalf of CIRP. en-copyright= kn-copyright= en-aut-name=OkamotoY. en-aut-sei=Okamoto en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkadaA. en-aut-sei=Okada en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KajitaniA. en-aut-sei=Kajitani en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShinonagaT. en-aut-sei=Shinonaga en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Natural Science & Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science & Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science & Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science & Technology, Okayama University kn-affil= en-keyword=Laser beam machining (LBM) kn-keyword=Laser beam machining (LBM) en-keyword=Laser micro machining kn-keyword=Laser micro machining en-keyword=Diamond kn-keyword=Diamond END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=1 article-no= start-page=1 end-page=3 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 2016 Incentive Award of the Okayama Medical Association in General Medical Science (2016 Yuuki Prize) kn-title=平成28年度岡山医学会賞　総合研究奨励賞（結城賞） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoSachiyo en-aut-sei=Okamoto en-aut-mei=Sachiyo kn-aut-name=岡本幸代 kn-aut-sei=岡本 kn-aut-mei=幸代 aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍・呼吸器内科学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=病院で働く精神科看護師がリカバリーの概念を理解するための体験プログラムの評価 kn-title=Evaluation of an experience-based program to understand the concept of recovery amonghospital-based psychiatric nurses en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoAki en-aut-sei=Okamoto en-aut-mei=Aki kn-aut-name=岡本亜紀 kn-aut-sei=岡本 kn-aut-mei=亜紀 aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=岡山大学大学院保健学研究科 END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=2 article-no= start-page=93 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The development of a scale to measure stress recognition during the treatment of diabetes patients kn-title=糖尿病患者の「治療に伴うストレス認知尺度」の開発 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　The purpose of this study was to establish a measurement scale for "stress recognition in receiving treatment" in patients with diabetes. A self-completed questionnaire was distributed to 149 type-2 diabetes outpatients in March-May 2015 after authorization from Okayama Prefectural University and the ethics committee of the hospital. 　The "stress recognition in receiving treatment" scale was designed as a second-order factor model consisting of 14 items and the following four factors : the respondent's sense of (1) the burden of being sick, (2) the burden on interpersonal relationships, (3) the burden of treatment, and (4) the burden of medical expenses. 　Stress recognition in treatment means recognition of being stressed in the burdens related to the illness, interpersonal relationships, treatment and medical expenses. 　The suitability of the questionnaire data was then evaluated with a structural equation model. The suitability of the factor model to the data satisfied the statistically acceptable standards as Comparative Fit Index (CFI) ＝0.931, Root Mean Square Error of Approximation (RMSEA) ＝0.096, Tucker-Lewis Index (TLI) ＝0.946. 　As the construct validity was not examined by the scale created in this study or by existing scale, it was verified by using the degrees of mental healthiness and HbA1c that were proved to be associated with the sense of burden. 　In addition, the construct validity of the questionnaire was supported by a significant correlation between the Japanese version of the WHO-Five Well-being Index (S-WHO-5-J) and the patients' HbA1c levels. The use of this measure is expected to contribute to the early detection of a decline in a diabetic patient's activities of daily living and to the early confirmation of patients' support status. en-copyright= kn-copyright= en-aut-name=SumiyoshiKazuko en-aut-sei=Sumiyoshi en-aut-mei=Kazuko kn-aut-name=住吉和子 kn-aut-sei=住吉 kn-aut-mei=和子 aut-affil-num=1 ORCID= en-aut-name=KawataChieko en-aut-sei=Kawata en-aut-mei=Chieko kn-aut-name=川田智恵子 kn-aut-sei=川田 kn-aut-mei=智恵子 aut-affil-num=2 ORCID= en-aut-name=OkamotoTatsuo en-aut-sei=Okamoto en-aut-mei=Tatsuo kn-aut-name=岡本辰夫 kn-aut-sei=岡本 kn-aut-mei=辰夫 aut-affil-num=3 ORCID= en-aut-name=OhashiMutsuko en-aut-sei=Ohashi en-aut-mei=Mutsuko kn-aut-name=大橋睦子 kn-aut-sei=大橋 kn-aut-mei=睦子 aut-affil-num=4 ORCID= en-aut-name=MikaneSakae en-aut-sei=Mikane en-aut-mei=Sakae kn-aut-name=實金栄 kn-aut-sei=實金 kn-aut-mei=栄 aut-affil-num=5 ORCID= en-aut-name=TakabayashiNoriko en-aut-sei=Takabayashi en-aut-mei=Noriko kn-aut-name=高林範子 kn-aut-sei=高林 kn-aut-mei=範子 aut-affil-num=6 ORCID= en-aut-name=FutoyuYoshiko en-aut-sei=Futoyu en-aut-mei=Yoshiko kn-aut-name=太湯好子 kn-aut-sei=太湯 kn-aut-mei=好子 aut-affil-num=7 ORCID= en-aut-name=KimWoesook en-aut-sei=Kim en-aut-mei=Woesook kn-aut-name=金外淑 kn-aut-sei=金 kn-aut-mei=外淑 aut-affil-num=8 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name=和田淳 kn-aut-sei=和田 kn-aut-mei=淳 aut-affil-num=9 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name=四方賢一 kn-aut-sei=四方 kn-aut-mei=賢一 aut-affil-num=10 ORCID= en-aut-name=NakajimaKazuo en-aut-sei=Nakajima en-aut-mei=Kazuo kn-aut-name=中嶋和夫 kn-aut-sei=中嶋 kn-aut-mei=和夫 aut-affil-num=11 ORCID= affil-num=1 en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University kn-affil=岡山県立大学　保健福祉学部 affil-num=2 en-affil=Health and Nursing Sciences Masters Program, Wakayama Medical University kn-affil=和歌山県立医科大学　大学院保健看護学研究科 affil-num=3 en-affil=Ryobi General Research Institute of Community Care kn-affil=両備地域ケア総合研究所 affil-num=4 en-affil=Department of Nursing, Okayama University Hospital kn-affil=岡山大学病院 看護部 affil-num=5 en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University kn-affil=岡山県立大学　保健福祉学部 affil-num=6 en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University kn-affil=岡山県立大学　保健福祉学部 affil-num=7 en-affil=School of Health Science and Social Welfare, Kibi International University kn-affil=吉備国際大学　保健医療福祉学部 affil-num=8 en-affil=College of Nursing Art and Science, University of Hyogo kn-affil=兵庫県立大学　看護学部 affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　腎・免疫・内分泌代謝内科学 affil-num=10 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=岡山大学病院　新医療研究開発センター affil-num=11 en-affil=Ryobi General Research Institute of Community Care kn-affil=両備地域ケア総合研究所 en-keyword=糖尿病患者 (diabetes patients) kn-keyword=糖尿病患者 (diabetes patients) en-keyword=治療 (treatment) kn-keyword=治療 (treatment) en-keyword=ストレス認知 (stress recognition) kn-keyword=ストレス認知 (stress recognition) en-keyword=尺度開発 (development of a scale) kn-keyword=尺度開発 (development of a scale) END start-ver=1.4 cd-journal=joma no-vol=J100-D cd-vols= no-issue=6 article-no= start-page=616 end-page=626 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Efficient Algorithm to Determine Equivalence of Pipelined Dependency Graphs for Their Simplification kn-title=パイプライン化依存性グラフを簡単化するための効率的な等価性判定アルゴリズム en-subtitle= kn-subtitle= en-abstract= kn-abstract=　依存性グラフに基づいた非同期式パイプライン制御回路の設計方法が提案されている．この設計法の最終段階においては，依存性グラフと縮小した依存性グラフの等価性を何度も繰返し判定することにより，簡単化した依存性グラフが得られる．しかし，この判定には多数の状態をもつオートマトンを扱うため，その計算量は極めて大きい．本論文では，この等価性判定のための新たな効率的なアルゴリズムを提案する．まず，基本操作の実行順序の半順序をコンパクトに表現するために，基本操作直結因果関係グラフ O˙ を定義する．次に，分 岐系列ごとに O˙ の高々二つの部分グラフが一致するとき，かつそのときに限り，二つの依存性グラフが等価であることを証明する．更に，等価性の判定に必要な分岐系列のサイズと数が有限であることを証明する．最後に，上述の原理を用いたアルゴリズムの計算量が従来法に比べて大幅に小さいことを示す． en-copyright= kn-copyright= en-aut-name=KagotaniHiroto en-aut-sei=Kagotani en-aut-mei=Hiroto kn-aut-name=籠谷裕人 kn-aut-sei=籠谷 kn-aut-mei=裕人 aut-affil-num=1 ORCID= en-aut-name=SugiyamaYuji en-aut-sei=Sugiyama en-aut-mei=Yuji kn-aut-name=杉山裕二 kn-aut-sei=杉山 kn-aut-mei=裕二 aut-affil-num=2 ORCID= en-aut-name=OkamotoTakuji en-aut-sei=Okamoto en-aut-mei=Takuji kn-aut-name=岡本卓爾 kn-aut-sei=岡本 kn-aut-mei=卓爾 aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology kn-affil=岡山大学大学院自然科学研究科 affil-num=2 en-affil=Graduate School of Natural Science and Technology kn-affil=岡山大学大学院自然科学研究科 affil-num=3 en-affil= kn-affil= en-keyword=非同期式制御回路 kn-keyword=非同期式制御回路 en-keyword=パイプライン kn-keyword=パイプライン en-keyword=簡単化 kn-keyword=簡単化 en-keyword=因果関係 kn-keyword=因果関係 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=気相浮遊物質に対し反応性を示す触媒/センサ用複合材料のマクロサイズでの構造制御 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoTakumi en-aut-sei=Okamoto en-aut-mei=Takumi kn-aut-name=岡本拓巳 kn-aut-sei=岡本 kn-aut-mei=拓巳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=207 end-page=212 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Long-term survival of two patients with esophageal neuroendocrine carcinoma who underwent multidisciplinary therapy kn-title=集学的治療により長期生存が得られた食道神経内分泌癌の2 例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Esophageal neuroendocrine carcinoma （ECC） is rare and has a poor prognosis when presenting with vascular invasion and distant metastasis from an early stage. Multidisciplinary therapy with surgery, chemotherapy, and radiation therapy may prolong survival in patients with advanced ECC, but there is as yet no standard therapy for advanced ECC. We treated two patients who have achieved long-term survival （＞ 4 years） who underwent multidisciplinary therapy, including chemotherapy, for ECC. Our experience with these two cases suggests that multidisciplinary therapy, including chemotherapy, may be effective for treating ECC at an advanced stage. en-copyright= kn-copyright= en-aut-name=GotodaTatsuhiro en-aut-sei=Gotoda en-aut-mei=Tatsuhiro kn-aut-name=後藤田達洋 kn-aut-sei=後藤田 kn-aut-mei=達洋 aut-affil-num=1 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=川野誠司 kn-aut-sei=川野 kn-aut-mei=誠司 aut-affil-num=2 ORCID= en-aut-name=KonoYoshiyasu en-aut-sei=Kono en-aut-mei=Yoshiyasu kn-aut-name=河野吉泰 kn-aut-sei=河野 kn-aut-mei=吉泰 aut-affil-num=3 ORCID= en-aut-name=MiuraKou en-aut-sei=Miura en-aut-mei=Kou kn-aut-name=三浦公 kn-aut-sei=三浦 kn-aut-mei=公 aut-affil-num=4 ORCID= en-aut-name=KanzakiHiromitsu en-aut-sei=Kanzaki en-aut-mei=Hiromitsu kn-aut-name=神崎洋光 kn-aut-sei=神崎 kn-aut-mei=洋光 aut-affil-num=5 ORCID= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=6 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=河原祥朗 kn-aut-sei=河原 kn-aut-mei=祥朗 aut-affil-num=7 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name=田中健大 kn-aut-sei=田中 kn-aut-mei=健大 aut-affil-num=8 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name=吉野正 kn-aut-sei=吉野 kn-aut-mei=正 aut-affil-num=9 ORCID= en-aut-name=ShirakawadYasuhiro en-aut-sei=Shirakawad en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=10 ORCID= en-aut-name=TabataMasahiro en-aut-sei=Tabata en-aut-mei=Masahiro kn-aut-name=田端雅弘 kn-aut-sei=田端 kn-aut-mei=雅弘 aut-affil-num=11 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=谷本光音 kn-aut-sei=谷本 kn-aut-mei=光音 aut-affil-num=12 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 affil-num=7 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=岡山大学病院　光学医療診療部 affil-num=8 en-affil=Department of Pathology, , Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　病理学（腫瘍病理） affil-num=9 en-affil=Department of Pathology, , Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　病理学（腫瘍病理） affil-num=10 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化管外科学 affil-num=11 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍内科学 affil-num=12 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　血液・腫瘍内科学 affil-num=13 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine， Dentistry and Pharmaceutical Sciences kn-affil=岡山大学大学院医歯薬学総合研究科　消化器・肝臓内科学 en-keyword=食道神経内分泌腫瘍（esophageal neuroendocrine carcinoma） kn-keyword=食道神経内分泌腫瘍（esophageal neuroendocrine carcinoma） en-keyword=小細胞癌（small cell carcinoma） kn-keyword=小細胞癌（small cell carcinoma） en-keyword=集学的治療（multidisciplinary therapy） kn-keyword=集学的治療（multidisciplinary therapy） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=抗IL-12/23 p40抗体は慢性GVHDのマウスモデルにおいて、IFN-γ/IL-17 double-producing細胞を抑制することで、GHVDを軽減化する kn-title=Anti-IL-12/23 p40 Antibody Attenuates Experimental Chronic Graft-versus-Host Disease via Suppression of IFN-γ/IL-17-Producing Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoSachiyo en-aut-sei=Okamoto en-aut-mei=Sachiyo kn-aut-name=岡本幸代 kn-aut-sei=岡本 kn-aut-mei=幸代 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=6 article-no= start-page=833 end-page=840 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ameliorative effect of propolis on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats kn-title=Propolis 長期投与による Otsuka Long-Evans Tokushima Fatty (OLETF) ラットの インスリン抵抗性改善作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=座間味義人 kn-aut-sei=座間味 kn-aut-mei=義人 aut-affil-num=1 ORCID= en-aut-name=FujiwaraHiroki en-aut-sei=Fujiwara en-aut-mei=Hiroki kn-aut-name=藤原弘喜 kn-aut-sei=藤原 kn-aut-mei=弘喜 aut-affil-num=2 ORCID= en-aut-name=HosodaMiho en-aut-sei=Hosoda en-aut-mei=Miho kn-aut-name=細田美穂 kn-aut-sei=細田 kn-aut-mei=美穂 aut-affil-num=3 ORCID= en-aut-name=HinoHayato en-aut-sei=Hino en-aut-mei=Hayato kn-aut-name=日野隼人 kn-aut-sei=日野 kn-aut-mei=隼人 aut-affil-num=4 ORCID= en-aut-name=HiraiKazuhiro en-aut-sei=Hirai en-aut-mei=Kazuhiro kn-aut-name=平井和浩 kn-aut-sei=平井 kn-aut-mei=和浩 aut-affil-num=5 ORCID= en-aut-name=OkamotoKazuaki en-aut-sei=Okamoto en-aut-mei=Kazuaki kn-aut-name=岡本和明 kn-aut-sei=岡本 kn-aut-mei=和明 aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=金鑫 kn-aut-sei=金 kn-aut-mei=鑫 aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高取真吾 kn-aut-sei=高取 kn-aut-mei=真吾 aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=高木志真 kn-aut-sei=高木 kn-aut-mei=志真 aut-affil-num=9 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=川﨑博己 kn-aut-sei=川﨑 kn-aut-mei=博己 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=4 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=6 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 affil-num=8 en-affil= kn-affil=日本新薬株式会社創薬研究所 affil-num=9 en-affil= kn-affil=山田養蜂場本社研究開発部 affil-num=10 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科臨床薬学分野 en-keyword=propolis kn-keyword=propolis en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=Otsuka Long-Evans Tokushima Fatty rat kn-keyword=Otsuka Long-Evans Tokushima Fatty rat en-keyword=periarterial nerve function kn-keyword=periarterial nerve function en-keyword=mesenteric vascular bed kn-keyword=mesenteric vascular bed END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=薄鋼板の析出挙動に関する基礎研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoRiki en-aut-sei=Okamoto en-aut-mei=Riki kn-aut-name=岡本力 kn-aut-sei=岡本 kn-aut-mei=力 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院 END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=55 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical guideline for the management of allergic rhinitis in Japan kn-title=鼻アレルギー診療ガイドライン―通年性鼻炎と花粉症― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MakiharaSeiichiro en-aut-sei=Makihara en-aut-mei=Seiichiro kn-aut-name=牧原靖一郎 kn-aut-sei=牧原 kn-aut-mei=靖一郎 aut-affil-num=1 ORCID= en-aut-name=OkanoMitsuhiro en-aut-sei=Okano en-aut-mei=Mitsuhiro kn-aut-name=岡野光博 kn-aut-sei=岡野 kn-aut-mei=光博 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=香川労災病院　耳鼻咽喉科・頭頸部外科 affil-num=2 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　耳鼻咽喉・頭頸部外科学 END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= start-page=139 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Organized and Sustainable Education Program for Drug Abuse Prevention by Yogo-teachers kn-title=養護教諭が推進する組織的で継続可能な小学校の喫煙・飲酒・薬物乱用防止教育プログラムの開発と実践 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　学校における喫煙・飲酒・薬物乱用防止教育の充実には，問題行動が顕在化する中学校期だけでなく小学校期 における指導の推進が重要であり，系統的な指導計画を立て，指導者や時間の確保，教材作成などに組織的に取 組み，継続可能なプログラム開発を行う必要がある。そこで，地区内12 校の養護教諭が協働して，発達段階に応 じた系統的・組織的かつ継続可能な地区共通の指導計画を開発し，各校の教育課程・年間計画に位置付けた実践 研究を行った。その結果，指導計画の実施状況は，小学校11 校中，学級活動10 校，ミニ保健指導10 校，長期 休業前指導6 校，広報活動9 校となり，特別支援学校1 校では広報活動のみを行うことができた。小学校におけ る喫煙・飲酒・薬物乱用防止教育の推進には，学校保健活動の中核的役割を担う養護教諭が専門性を活かし協働 して，系統的な指導計画を各校の教育課程に位置付け組織的で継続可能なプログラムとする取組が有効であった。 en-copyright= kn-copyright= en-aut-name=UenoYoshiko en-aut-sei=Ueno en-aut-mei=Yoshiko kn-aut-name=上野芳子 kn-aut-sei=上野 kn-aut-mei=芳子 aut-affil-num=1 ORCID= en-aut-name=NishimuraTakae en-aut-sei=Nishimura en-aut-mei=Takae kn-aut-name=西村孝江 kn-aut-sei=西村 kn-aut-mei=孝江 aut-affil-num=2 ORCID= en-aut-name=HosakaSayuri en-aut-sei=Hosaka en-aut-mei=Sayuri kn-aut-name=保坂小百合 kn-aut-sei=保坂 kn-aut-mei=小百合 aut-affil-num=3 ORCID= en-aut-name=YamamotoMasae en-aut-sei=Yamamoto en-aut-mei=Masae kn-aut-name=山本雅恵 kn-aut-sei=山本 kn-aut-mei=雅恵 aut-affil-num=4 ORCID= en-aut-name=AkasakaRie en-aut-sei=Akasaka en-aut-mei=Rie kn-aut-name=赤坂理恵 kn-aut-sei=赤坂 kn-aut-mei=理恵 aut-affil-num=5 ORCID= en-aut-name=ArimatuAyumi en-aut-sei=Arimatu en-aut-mei=Ayumi kn-aut-name=有松亜由美 kn-aut-sei=有松 kn-aut-mei=亜由美 aut-affil-num=6 ORCID= en-aut-name=FujiiHarue en-aut-sei=Fujii en-aut-mei=Harue kn-aut-name=藤井治江 kn-aut-sei=藤井 kn-aut-mei=治江 aut-affil-num=7 ORCID= en-aut-name=YuguchiMakoto en-aut-sei=Yuguchi en-aut-mei=Makoto kn-aut-name=湯口真琴 kn-aut-sei=湯口 kn-aut-mei=真琴 aut-affil-num=8 ORCID= en-aut-name=TorigoeKanako en-aut-sei=Torigoe en-aut-mei=Kanako kn-aut-name=鳥越加奈子 kn-aut-sei=鳥越 kn-aut-mei=加奈子 aut-affil-num=9 ORCID= en-aut-name=OonishiMarika en-aut-sei=Oonishi en-aut-mei=Marika kn-aut-name=大西真莉香 kn-aut-sei=大西 kn-aut-mei=真莉香 aut-affil-num=10 ORCID= en-aut-name=NanbaYumiko en-aut-sei=Nanba en-aut-mei=Yumiko kn-aut-name=難波有美子 kn-aut-sei=難波 kn-aut-mei=有美子 aut-affil-num=11 ORCID= en-aut-name=MoriAyako en-aut-sei=Mori en-aut-mei=Ayako kn-aut-name=森文子 kn-aut-sei=森 kn-aut-mei=文子 aut-affil-num=12 ORCID= en-aut-name=WashidaHiroe en-aut-sei=Washida en-aut-mei=Hiroe kn-aut-name=鷲田洋恵 kn-aut-sei=鷲田 kn-aut-mei=洋恵 aut-affil-num=13 ORCID= en-aut-name=NishimotoKeiko en-aut-sei=Nishimoto en-aut-mei=Keiko kn-aut-name=西本圭子 kn-aut-sei=西本 kn-aut-mei=圭子 aut-affil-num=14 ORCID= en-aut-name=HinoYuko en-aut-sei=Hino en-aut-mei=Yuko kn-aut-name=日野裕子 kn-aut-sei=日野 kn-aut-mei=裕子 aut-affil-num=15 ORCID= en-aut-name=MatumotoTomoko en-aut-sei=Matumoto en-aut-mei=Tomoko kn-aut-name=松本智子 kn-aut-sei=松本 kn-aut-mei=智子 aut-affil-num=16 ORCID= en-aut-name=IshiharaTomoko en-aut-sei=Ishihara en-aut-mei=Tomoko kn-aut-name=石原智子 kn-aut-sei=石原 kn-aut-mei=智子 aut-affil-num=17 ORCID= en-aut-name=TodoMariko en-aut-sei=Todo en-aut-mei=Mariko kn-aut-name=藤堂真莉子 kn-aut-sei=藤堂 kn-aut-mei=真莉子 aut-affil-num=18 ORCID= en-aut-name=YamamotoKumiko en-aut-sei=Yamamoto en-aut-mei=Kumiko kn-aut-name=山本久美子 kn-aut-sei=山本 kn-aut-mei=久美子 aut-affil-num=19 ORCID= en-aut-name=SadamoriNatuki en-aut-sei=Sadamori en-aut-mei=Natuki kn-aut-name=定森奈月 kn-aut-sei=定森 kn-aut-mei=奈月 aut-affil-num=20 ORCID= en-aut-name=YamagamiNao en-aut-sei=Yamagami en-aut-mei=Nao kn-aut-name=山上奈緒 kn-aut-sei=山上 kn-aut-mei=奈緒 aut-affil-num=21 ORCID= en-aut-name=OkamotoKanako en-aut-sei=Okamoto en-aut-mei=Kanako kn-aut-name=岡本佳菜子 kn-aut-sei=岡本 kn-aut-mei=佳菜子 aut-affil-num=22 ORCID= en-aut-name=MatsuoHiromi en-aut-sei=Matsuo en-aut-mei=Hiromi kn-aut-name=松尾裕未 kn-aut-sei=松尾 kn-aut-mei=裕未 aut-affil-num=23 ORCID= en-aut-name=KobayashiShizuka en-aut-sei=Kobayashi en-aut-mei=Shizuka kn-aut-name=小林静香 kn-aut-sei=小林 kn-aut-mei=静香 aut-affil-num=24 ORCID= en-aut-name=HayashiKanako en-aut-sei=Hayashi en-aut-mei=Kanako kn-aut-name=林加奈子 kn-aut-sei=林 kn-aut-mei=加奈子 aut-affil-num=25 ORCID= en-aut-name=MizushimaNozomi en-aut-sei=Mizushima en-aut-mei=Nozomi kn-aut-name=水島希望 kn-aut-sei=水島 kn-aut-mei=希望 aut-affil-num=26 ORCID= en-aut-name=SekiyamaKen-ichi en-aut-sei=Sekiyama en-aut-mei=Ken-ichi kn-aut-name=関山賢一 kn-aut-sei=関山 kn-aut-mei=賢一 aut-affil-num=27 ORCID= en-aut-name=FukushimaTakashi en-aut-sei=Fukushima en-aut-mei=Takashi kn-aut-name=福嶋隆 kn-aut-sei=福嶋 kn-aut-mei=隆 aut-affil-num=28 ORCID= en-aut-name=KamimuraHiroko en-aut-sei=Kamimura en-aut-mei=Hiroko kn-aut-name=上村弘子 kn-aut-sei=上村 kn-aut-mei=弘子 aut-affil-num=29 ORCID= en-aut-name=TakahashiKayo en-aut-sei=Takahashi en-aut-mei=Kayo kn-aut-name=高橋香代 kn-aut-sei=高橋 kn-aut-mei=香代 aut-affil-num=30 ORCID= affil-num=1 en-affil= kn-affil=倉敷市立西阿知小学校 affil-num=2 en-affil= kn-affil=倉敷市立粒江小学校 affil-num=3 en-affil= kn-affil=倉敷市立連島北小学校 affil-num=4 en-affil= kn-affil=倉敷市立老松小学校 affil-num=5 en-affil= kn-affil=倉敷市立老松小学校 affil-num=6 en-affil= kn-affil=倉敷市立老松小学校 affil-num=7 en-affil= kn-affil=倉敷市立大高小学校 affil-num=8 en-affil= kn-affil=倉敷市立大高小学校 affil-num=9 en-affil= kn-affil=倉敷市立大高小学校 affil-num=10 en-affil= kn-affil=倉敷市立中洲小学校 affil-num=11 en-affil= kn-affil=倉敷市立中洲小学校 affil-num=12 en-affil= kn-affil=倉敷市立天城小学校 affil-num=13 en-affil= kn-affil=倉敷市立西阿知小学校 affil-num=14 en-affil= kn-affil=倉敷市立西阿知小学校 affil-num=15 en-affil= kn-affil=倉敷市立西阿知小学校 affil-num=16 en-affil= kn-affil=倉敷市立倉敷南小学校 affil-num=17 en-affil= kn-affil=倉敷市立中島小学校 affil-num=18 en-affil= kn-affil=倉敷市立中島小学校 affil-num=19 en-affil= kn-affil=倉敷市立葦高小学校 affil-num=20 en-affil= kn-affil=倉敷市立葦高小学校 affil-num=21 en-affil= kn-affil=倉敷市立旭丘小学校 affil-num=22 en-affil= kn-affil=倉敷市立旭丘小学校 affil-num=23 en-affil= kn-affil=倉敷市立倉敷支援学校 affil-num=24 en-affil= kn-affil=倉敷市立倉敷支援学校 affil-num=25 en-affil= kn-affil=倉敷市立倉敷支援学校 affil-num=26 en-affil= kn-affil=倉敷市立倉敷支援学校 affil-num=27 en-affil= kn-affil=倉敷市立葦高小学校 affil-num=28 en-affil= kn-affil=倉敷市立老松小学校 affil-num=29 en-affil= kn-affil=岡山大学大学院教育学研究科 affil-num=30 en-affil= kn-affil=くらしき作陽大学こども教育学部 en-keyword=小学校 kn-keyword=小学校 en-keyword=健康教育 kn-keyword=健康教育 en-keyword=喫煙・飲酒・薬物乱用防止教育 kn-keyword=喫煙・飲酒・薬物乱用防止教育 en-keyword=養護教諭 kn-keyword=養護教諭 en-keyword=中核的役割 kn-keyword=中核的役割 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=127 end-page=131 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fermented persimmon extract (kaki-shibu) is useful as a standard for component analyses of persimmon phytobezoars kn-title=柿胃石の成分分析における標準物質としての柿渋の有用性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The definite diagnosis of persimmon phytobezoar (i.e., diospyrobezoar) is often accomplished by a component analysis using infrared spectroscopy. However, no studies have been conducted to investigate which substance is the best as a standard for the component analysis. Here we analyzed tannic acid, Japanese persimmon (kaki), fermented persimmon extract (kaki-shibu), conventional dried persimmon, and dried persimmon smoked in sulfur (ampo-kaki) by infrared spectroscopy to determine which would be optimal as a component analysis standard. The spectrum between 1,600 to 600cm－1 of a persimmon phytobezoar was quite similar to the spectrum of kaki-shibu rather than that of tannic acid. Consequently, we conclude that kaki-shibu should be used as a standard for infrared spectroscopy analyses of persimmon phytobezoars. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=岩室雅也 kn-aut-sei=岩室 kn-aut-mei=雅也 aut-affil-num=1 ORCID= en-aut-name=OkamotoYuko en-aut-sei=Okamoto en-aut-mei=Yuko kn-aut-name=岡本裕子 kn-aut-sei=岡本 kn-aut-mei=裕子 aut-affil-num=2 ORCID= en-aut-name=MurataToshihiro en-aut-sei=Murata en-aut-mei=Toshihiro kn-aut-name=村田年弘 kn-aut-sei=村田 kn-aut-mei=年弘 aut-affil-num=3 ORCID= en-aut-name=KawaiYoshinari en-aut-sei=Kawai en-aut-mei=Yoshinari kn-aut-name=河合良成 kn-aut-sei=河合 kn-aut-mei=良成 aut-affil-num=4 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name=白羽英則 kn-aut-sei=白羽 kn-aut-mei=英則 aut-affil-num=5 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=岡田裕之 kn-aut-sei=岡田 kn-aut-mei=裕之 aut-affil-num=6 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=山本和秀 kn-aut-sei=山本 kn-aut-mei=和秀 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 affil-num=2 en-affil= kn-affil=井原市立井原市民病院　内科 affil-num=3 en-affil= kn-affil=尾道市立市民病院 外科 affil-num=4 en-affil= kn-affil=尾道市立市民病院 消化器内科 affil-num=5 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 affil-num=6 en-affil= kn-affil=岡山大学病院　光学医療診療部 affil-num=7 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科 消化器・肝臓内科学 en-keyword=柿胃石（gastric phytobezoar） kn-keyword=柿胃石（gastric phytobezoar） en-keyword=タンニン酸（tannic acid） kn-keyword=タンニン酸（tannic acid） en-keyword=消化管異物（gastrointestinal foreign body） kn-keyword=消化管異物（gastrointestinal foreign body） en-keyword=成分分析（component analysis） kn-keyword=成分分析（component analysis） END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=117 end-page=126 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The origin of infra-slow oscillations of oxygenated hemoglobin observed in functional near-infrared spectroscopy kn-title=光トポグラフィーでみられる酸素化ヘモグロビン量の低周波変動の発生源に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There is increasing interest in the intrinsic activity of the resting brain, especially the activity slower than 0.1Hz (i.e., low-frequency oscillations, or LFOs). To investigate the origin of LFOs observed in functional near-infrared spectroscopy (fNIRS), we recorded multichannel fNIRS and electroencephalography (EEG) from the frontal cortex of 11 healthy young volunteers in the resting state. Electrocardiography (ECG), electro-oculography and respiration were also measured. Synchronous oscillations of oxy-hemoglobin (oxy-Hb) around 1.0Hz were detected in all fNIRS channels, and their frequency was consistent with a peak frequency of ECG, suggesting the changes of cerebral blood flow due to heart beats. In addition, oxy-Hb oscillations around 0.1Hz (i.e., LFOs) appeared in the fNIRS. The channels where LFOs appeared differed among the subjects, and the LFOs appeared or disappeared even in the same fNIRS channels. The appearance of LFOs in fNIRS channels was significantly higher when the LFOs appeared on the EEG in the adjacent EEG electrodes compared to when LFOs did not appear on EEG. The amplitude and coherence (synchronicity) of the LFOs were increased by changing the subjects' position from dorsal to the sitting position in both fNIRS and EEG, and the coherence in particular was increased in the homologous fNIRS channels on the bilateral hemispheres. These results suggest that LFOs of oxy-Hb couple with resting-state EEG activity. en-copyright= kn-copyright= en-aut-name=ShoshiChikafumi en-aut-sei=Shoshi en-aut-mei=Chikafumi kn-aut-name=所司睦文 kn-aut-sei=所司 kn-aut-mei=睦文 aut-affil-num=1 ORCID= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name=上野浩司 kn-aut-sei=上野 kn-aut-mei=浩司 aut-affil-num=2 ORCID= en-aut-name=KuboMasako en-aut-sei=Kubo en-aut-mei=Masako kn-aut-name=久保正子 kn-aut-sei=久保 kn-aut-mei=正子 aut-affil-num=3 ORCID= en-aut-name=OdaMasuko en-aut-sei=Oda en-aut-mei=Masuko kn-aut-name=小田真珠子 kn-aut-sei=小田 kn-aut-mei=真珠子 aut-affil-num=4 ORCID= en-aut-name=HirataNaoya en-aut-sei=Hirata en-aut-mei=Naoya kn-aut-name=平田直也 kn-aut-sei=平田 kn-aut-mei=直也 aut-affil-num=5 ORCID= en-aut-name=TakemotoRika en-aut-sei=Takemoto en-aut-mei=Rika kn-aut-name=武本梨佳 kn-aut-sei=武本 kn-aut-mei=梨佳 aut-affil-num=6 ORCID= en-aut-name=KinugasaKazushi en-aut-sei=Kinugasa en-aut-mei=Kazushi kn-aut-name=衣笠和孜 kn-aut-sei=衣笠 kn-aut-mei=和孜 aut-affil-num=7 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=岡本基 kn-aut-sei=岡本 kn-aut-mei=基 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=川崎医療短期大学　臨床検査科 affil-num=2 en-affil= kn-affil=近畿大学医学部　薬理学講座 affil-num=3 en-affil= kn-affil=東京工科大学医療保健学部　看護学科 affil-num=4 en-affil= kn-affil=倉敷成人病健診センター affil-num=5 en-affil= kn-affil=福山市民病院 affil-num=6 en-affil= kn-affil=岡山大学病院　医療技術部 affil-num=7 en-affil= kn-affil=岡山療護センター affil-num=8 en-affil= kn-affil=岡山大学大学院保健学研究科　検査技術科学 en-keyword=fNIRS kn-keyword=fNIRS en-keyword=EEG kn-keyword=EEG en-keyword=LFOs kn-keyword=LFOs en-keyword=コヒーレンス解析（Coherence analysis） kn-keyword=コヒーレンス解析（Coherence analysis） en-keyword=連続ウェーブレット解析（continuous wavelet transforms） kn-keyword=連続ウェーブレット解析（continuous wavelet transforms） END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=小児の病院外心停止症例の特徴と転帰についての地域差に関する検討 kn-title=Regional Variation in Survival Following Pediatric Out-of-Hospital Cardiac Arrest en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoYoshio en-aut-sei=Okamoto en-aut-mei=Yoshio kn-aut-name=岡本吉生 kn-aut-sei=岡本 kn-aut-mei=吉生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=27 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the influence of Zhen zhong ji in Song Shi kn-title=宋詩にみえる「枕中記」の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoFujiaki en-aut-sei=Okamoto en-aut-mei=Fujiaki kn-aut-name=岡本不二明 kn-aut-sei=岡本 kn-aut-mei=不二明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=39 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil kn-title=術前DCF療法が著効した食道原発内分泌細胞癌の１切除例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Esophageal endocrine cell carcinoma is extremely rare. We report a case of esophageal endocrine cell carcinoma showing histological complete response to neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (DCF). A 66-year-old man had been experiencing epigastralgia, and a type 2 tumor in the thoracic part of esophagus was detected by upper endoscopy. The biopsy showed endocrine cell carcinoma. PET/CT, endoscopy and an esophagogram showed that the patient had a 70-mm scaled type 2 tumor in the middle thoracic esophagus, and they also revealed lymph node metastases (no. 106recR). We diagnosed a cT3cN1cM0 cStage III tumor. With two courses of DCF treatment, both the primary tumor and lymph node metastases showed a partial response. We performed a subtotal esophagectomy with three-field lymph node dissection. The pathological examination of the resected specimens revealed no malignant cells in the esophagus or lymph nodes, and we concluded that the pathological effect of the DCF treatment was Grade 3. en-copyright= kn-copyright= en-aut-name=MaedaNaoaki en-aut-sei=Maeda en-aut-mei=Naoaki kn-aut-name=前田直見 kn-aut-sei=前田 kn-aut-mei=直見 aut-affil-num=1 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=2 ORCID= en-aut-name=KoujimaTakeshi en-aut-sei=Koujima en-aut-mei=Takeshi kn-aut-name=國府島健 kn-aut-sei=國府島 kn-aut-mei=健 aut-affil-num=3 ORCID= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name=大原利章 kn-aut-sei=大原 kn-aut-mei=利章 aut-affil-num=4 ORCID= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name=田邊俊輔 kn-aut-sei=田邊 kn-aut-mei=俊輔 aut-affil-num=5 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name=野間和広 kn-aut-sei=野間 kn-aut-mei=和広 aut-affil-num=6 ORCID= en-aut-name=SakuramaKazuhumi en-aut-sei=Sakurama en-aut-mei=Kazuhumi kn-aut-name=櫻間教文 kn-aut-sei=櫻間 kn-aut-mei=教文 aut-affil-num=7 ORCID= en-aut-name=FujiwaraToshiyosi en-aut-sei=Fujiwara en-aut-mei=Toshiyosi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=2 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=3 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=4 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=5 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=6 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=7 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=8 en-affil= kn-affil=岡山大学病院　消化管外科 en-keyword=食道癌（esophageal cancer） kn-keyword=食道癌（esophageal cancer） en-keyword=内分泌細胞癌（endocrine cell carcinoma） kn-keyword=内分泌細胞癌（endocrine cell carcinoma） en-keyword=DCF療法（DCF treatment） kn-keyword=DCF療法（DCF treatment） END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=35 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of colon lipoma presenting with intussusception kn-title=腸重積で発症した結腸脂肪腫の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　An 84-year-old man, who had been found to have a submucosal tumor in the ascending colon two years before, was admitted to our hospital for right lower quadrant abdominal pain and melena. An abdominal computed tomography (CT) scan showed intussusception in the ascending colon, resulting from a fat-density tumor. The intussusception was located by colonoscopy. Since the colonic tumor was enlarged in comparison with two years ago and had an ulcer at the top of the tumor, there was the possibility of malignancy and recurrence of intussusception. He underwent a laparoscopy-assisted right colectomy with lymph node dissection. Pathologically, the tumor of the ascending colon was a benign lipoma. en-copyright= kn-copyright= en-aut-name=NinomiyaTakayuki en-aut-sei=Ninomiya en-aut-mei=Takayuki kn-aut-name=二宮卓之 kn-aut-sei=二宮 kn-aut-mei=卓之 aut-affil-num=1 ORCID= en-aut-name=OjimaYasutomo en-aut-sei=Ojima en-aut-mei=Yasutomo kn-aut-name=小島康知 kn-aut-sei=小島 kn-aut-mei=康知 aut-affil-num=2 ORCID= en-aut-name=HaranoMasao en-aut-sei=Harano en-aut-mei=Masao kn-aut-name=原野雅生 kn-aut-sei=原野 kn-aut-mei=雅生 aut-affil-num=3 ORCID= en-aut-name=OhnoSatoshi en-aut-sei=Ohno en-aut-mei=Satoshi kn-aut-name=大野聡 kn-aut-sei=大野 kn-aut-mei=聡 aut-affil-num=4 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=塩崎滋弘 kn-aut-sei=塩崎 kn-aut-mei=滋弘 aut-affil-num=5 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=二宮基樹 kn-aut-sei=二宮 kn-aut-mei=基樹 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=2 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil= kn-affil=広島市立広島市民病院　外科 en-keyword=結腸脂肪腫（lipoma of the colon） kn-keyword=結腸脂肪腫（lipoma of the colon） en-keyword=腸重積（intussusception） kn-keyword=腸重積（intussusception） en-keyword=腹腔鏡下手術（laparoscopic surgery） kn-keyword=腹腔鏡下手術（laparoscopic surgery） END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=239 end-page=242 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of appendiceal diverticulum resected by laparoscopic surgery with preoperative diagnosis of appendiceal tumor kn-title=虫垂腫瘍と術前診断し腹腔鏡下手術を行った虫垂仮性憩室症の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　Appendiceal diverticulum is rare. We encountered a case of appendiceal diverticulum with chronic appendicitis. A 56-year-old man presented to our hospital with right lower abdominal pain. An abdominal computed tomography (CT) scan showed swelling of the appendix body and the wall thickness of the base of the appendix. Due to the possibility of appendiceal tumor, we performed a laparoscopy-assisted ileocecal resection with lymph node dissection. The appendix had a diverticulum with chronic inflammation, but it did not have a neoplastic lesion. en-copyright= kn-copyright= en-aut-name=NinomiyaTakayuki en-aut-sei=Ninomiya en-aut-mei=Takayuki kn-aut-name=二宮卓之 kn-aut-sei=二宮 kn-aut-mei=卓之 aut-affil-num=1 ORCID= en-aut-name=OjimaYasutomo en-aut-sei=Ojima en-aut-mei=Yasutomo kn-aut-name=小島康知 kn-aut-sei=小島 kn-aut-mei=康知 aut-affil-num=2 ORCID= en-aut-name=HaranoMasao en-aut-sei=Harano en-aut-mei=Masao kn-aut-name=原野雅生 kn-aut-sei=原野 kn-aut-mei=雅生 aut-affil-num=3 ORCID= en-aut-name=OhnoSatoshi en-aut-sei=Ohno en-aut-mei=Satoshi kn-aut-name=大野聡 kn-aut-sei=大野 kn-aut-mei=聡 aut-affil-num=4 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=塩崎滋弘 kn-aut-sei=塩崎 kn-aut-mei=滋弘 aut-affil-num=5 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=二宮基樹 kn-aut-sei=二宮 kn-aut-mei=基樹 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=2 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=3 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=4 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=5 en-affil= kn-affil=広島市立広島市民病院　外科 affil-num=6 en-affil= kn-affil=広島市立広島市民病院　外科 en-keyword=虫垂憩室症（appendiceal diverculum） kn-keyword=虫垂憩室症（appendiceal diverculum） en-keyword=腹腔鏡手術（laparoscopic surgery） kn-keyword=腹腔鏡手術（laparoscopic surgery） en-keyword=虫垂腫瘍（appendiceal tumor） kn-keyword=虫垂腫瘍（appendiceal tumor） END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=2 article-no= start-page=103 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the microbiological decomposition of pectin. XII. Distribution of pectinase in higher plants. kn-title=ペクチン醗酵に就いて 第12報 高等植物のペクチナーゼの檢出 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=1 ORCID= en-aut-name=OkamotoK. en-aut-sei=Okamoto en-aut-mei=K. kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=2 article-no= start-page=135 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical study of single-incision laparoscopic cholecystectomy kn-title=単孔式腹腔鏡下胆嚢摘出術の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced 63 patients with non-inflammatory disease who underwent single-incision laparoscopic cholecystectomy (TANKO-LC). Herein we report the procedure of operation and the short-term results. We compared 63 cases of TANKO-LC with 109 cases of non-inflammatory conventional laparoscopic cholecystectomy (S-LC) within the same period. At first, our standard procedure was to insert multiple trocars in the abdominal cavity through a single wound ; now, we insert only a single trocar all cases. In the 63 cases investigation, 3 cases required trocar addition and one case converted to open surgery. Intra and postoperative complications were recognized in 2 cases (port-site infection). No significant complications were recognized. In comparing the TANKO-LC group and the S-LC group, the operation time was intentionally longer in the TANKO-LC group (TANKO-LC group : 118 min, S-LC group : 90 min), but there were no differences in the blood loss, the rates of intra and postoperative complications and the conversion rate. Laparoscopic cholecystectomy is a standard operation for gallbladder removal, but single-incision laparoscopic cholecystectomy is considered a useful operation with the same low operative complication rate yet more satisfactory cosmetic results. en-copyright= kn-copyright= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=2 ORCID= en-aut-name=IsodaKenta en-aut-sei=Isoda en-aut-mei=Kenta kn-aut-name=磯田健太 kn-aut-sei=磯田 kn-aut-mei=健太 aut-affil-num=3 ORCID= en-aut-name=KitadaKouji en-aut-sei=Kitada en-aut-mei=Kouji kn-aut-name=北田浩二 kn-aut-sei=北田 kn-aut-mei=浩二 aut-affil-num=4 ORCID= en-aut-name=HamanoRyousuke en-aut-sei=Hamano en-aut-mei=Ryousuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=5 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=6 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=7 ORCID= en-aut-name=TsunemitsuYousuke en-aut-sei=Tsunemitsu en-aut-mei=Yousuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=8 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=9 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター 外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター 外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター 外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター 外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター 外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター 外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター 外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター 外科 affil-num=9 en-affil= kn-affil=国立病院機構福山医療センター 外科 affil-num=10 en-affil= kn-affil=国立病院機構福山医療センター 外科 en-keyword=腹腔鏡下胆嚢摘出術（laparoscopic cholecystectomy） kn-keyword=腹腔鏡下胆嚢摘出術（laparoscopic cholecystectomy） en-keyword=単孔式（single-incision） kn-keyword=単孔式（single-incision） END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=2 article-no= start-page=61 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=196403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The thiobarbituric acid test of 4,5-unsaturated digalacturonic acid. kn-title=4,5-不飽和ヂガラクチュロン酸のチオバルビツール酸反応 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoK. en-aut-sei=Okamoto en-aut-mei=K. kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=1 ORCID= en-aut-name=HatanakaC. en-aut-sei=Hatanaka en-aut-mei=C. kn-aut-name=畑中千歳 kn-aut-sei=畑中 kn-aut-mei=千歳 aut-affil-num=2 ORCID= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=3 article-no= start-page=137 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=1962 dt-pub=196203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the metabolism of uronic acids. 3. Properties of an intermediate in pectic acid metabolism by Erwinia aroideae: Products by ozone and periodate Oxidation. kn-title=ウロン酸の代謝に関する研究(3)　Erwinia aroideaeによるペクチン酸の代謝中間生成物の性質―オゾン酸化と過沃素酸酸化による生成物 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoK. en-aut-sei=Okamoto en-aut-mei=K. kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=1 ORCID= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3 article-no= start-page=135 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Somatosensory and Visual Deprivation Each Decrease the Density of Parvalbumin Neurons and Their Synapse Terminals in the Prefrontal Cortex and Hippocampus of Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the phenomenon known as cross-modal plasticity, the loss of one sensory system is followed by improved functioning of other intact sensory systems. MRI and functional MRI studies suggested a role of the prefrontal cortex and the temporal lobe in cross-modal plasticity. We used a mouse model to examine the effects of sensory deprivation achieved by whisker trimming and visual deprivation achieved by dark rearing in neonatal mice on the appearance of parvalbumin (PV) neurons and the formation of glutamic acid decarboxylase 67 (GAD67)-positive puncta around pyramidal neurons in the prefrontal cortex and hippocampus. Whisker trimming, but not dark rearing, decreased the density of PV neurons in the hippocampus at postnatal day 28 (P28). In the prefrontal cortex, whisker trimming and dark rearing decreased the density of PV neurons in layer 5/6 (L5/6) at P28 and in L2/3 at P56, respectively, whereas dark rearing increased the density of PV neurons in L5/6 at P56. Whisker trimming decreased the density of GAD67-positive puncta in CA1 of the hippocampus at both P28 and P56 and in L5/6 of the prefrontal cortex at P28. Dark rearing decreased the density of GAD67-positive puncta in CA1 of the hippocampus and in both L2/3 and L5/6 of the prefrontal cortex at P28, and in L2/3 of the prefrontal cortex at P56. These results demonstrate that somatosensory or visual deprivation causes changes in the PV-interneuronal network in the mouse prefrontal cortex and hippocampus. The results also suggest that the alteration of the PV-interneuronal network, especially in the prefrontal cortex, may contribute to cross-modal plasticity. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShoshiChikafumi en-aut-sei=Shoshi en-aut-mei=Chikafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UsuiShinichi en-aut-sei=Usui en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SujiuraHiroko en-aut-sei=Sujiura en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Department of Medical Technology, Kawasaki College of Allied Health Professions affil-num=3 en-affil= kn-affil=Department of Psychiatry, Kawasaki Medical University affil-num=4 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University en-keyword=sensory deprivation kn-keyword=sensory deprivation en-keyword=parvalbumin kn-keyword=parvalbumin en-keyword=glutamate decarboxylase (GAD67) kn-keyword=glutamate decarboxylase (GAD67) en-keyword=prefrontal cortex kn-keyword=prefrontal cortex en-keyword=hippocampus kn-keyword=hippocampus END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue=1 article-no= start-page=39 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=196012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the metabolism of uronic acids. 2. Some properties of an intermediate compound in pectic acid metabolism by Erwinia aroideae. kn-title=ウロン酸の代謝に関する研究（2）　Erwinia aroideae によるペクチン酸の代謝中間生成物の性質 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoK. en-aut-sei=Okamoto en-aut-mei=K. kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=1 ORCID= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=1-2 article-no= start-page=105 end-page=110 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195911 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the pectin-polygalacturonase of Saccharomyces fragilis. kn-title=Saccharomayces fragilisのペクチン―ポリガラクトウロナーゼについて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=1 ORCID= en-aut-name=OkamotoA. en-aut-sei=Okamoto en-aut-mei=A. kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=2 ORCID= en-aut-name=HayashiT. en-aut-sei=Hayashi en-aut-mei=T. kn-aut-name=林哲吾 kn-aut-sei=林 kn-aut-mei=哲吾 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=1-2 article-no= start-page=39 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195911 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the chemical control of white root-rot of vines. I. First screening test with fungicides in the liquid form. kn-title=ブドウ白紋羽病の薬剤防除に関する研究　第1報　薬剤（液剤）スクリーニングテスト en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamauchiK. en-aut-sei=Yamauchi en-aut-mei=K. kn-aut-name=山内己酉 kn-aut-sei=山内 kn-aut-mei=己酉 aut-affil-num=1 ORCID= en-aut-name=ShiomiM. en-aut-sei=Shiomi en-aut-mei=M. kn-aut-name=塩見正保 kn-aut-sei=塩見 kn-aut-mei=正保 aut-affil-num=2 ORCID= en-aut-name=OkamotoY. en-aut-sei=Okamoto en-aut-mei=Y. kn-aut-name=岡本康博 kn-aut-sei=岡本 kn-aut-mei=康博 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=3 article-no= start-page=142 end-page=149 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=麦斑葉モザイク病感染時期のビール大麦および小麦の收量,種子伝染におよぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井上忠男 kn-aut-sei=井上 kn-aut-mei=忠男 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本康博 kn-aut-sei=岡本 kn-aut-mei=康博 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=3 article-no= start-page=129 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=植物病原菌に対する抗菌物質を生産する微生物の利用に関する研究　第5報　Streptomyces albus C 1-2株の土壌中でのImoticidinの生産,およびCorticium centrifugumに対する土壌中でのImoticidinの効果 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井上忠男 kn-aut-sei=井上 kn-aut-mei=忠男 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本康博 kn-aut-sei=岡本 kn-aut-mei=康博 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=3 article-no= start-page=120 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=植物病原菌に対する抗菌物質を生産する微生物の利用に関する研究　第4報　Streptomyces albus C 1-2株の生産する新抗菌物質,Imoticidinについて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井上忠男 kn-aut-sei=井上 kn-aut-mei=忠男 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本康博 kn-aut-sei=岡本 kn-aut-mei=康博 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=2 article-no= start-page=49 end-page=53 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=195810 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ウロン酸の代謝に関する研究（1）　Erwinia aroideaeのウロン酸代謝 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=1 article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=195708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Erwinia aroideaeの糖化型ポリガラクチユロナーゼについて en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=3 article-no= start-page=119 end-page=126 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=195612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=植物病原菌に對する抗菌物質を生産する微生物の利用に関する硏究（第3報）　土壤対抗法による2,3の実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本康博 kn-aut-sei=岡本 kn-aut-mei=康博 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井上忠男 kn-aut-sei=井上 kn-aut-mei=忠男 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=2 article-no= start-page=81 end-page=85 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=195610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Erwiniaのペクチン－ポリガラクチユロナーゼ産生条件について（第2報）　炭素源の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=1 article-no= start-page=34 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=195603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Erwiniaのペクチン－ポリガラクチユロナーゼ産生条件について　１無機塩類の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=4 article-no= start-page=165 end-page=171 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=植物病原菌に對する抗菌物質を生産する微生物の利用に関する硏究（第2報）　無殺菌土壤で白絹病菌Corticium centrifugumに有効な対抗放線菌2株 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井上忠男 kn-aut-sei=井上 kn-aut-mei=忠男 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本康博 kn-aut-sei=岡本 kn-aut-mei=康博 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=2 article-no= start-page=63 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550620 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=植物病原菌に対する抗菌物質を生産する微生物の利用に関する硏究（I）　Streptomyces sp. 30-10株とそれの生産する抗糸狀菌物質 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井上忠男 kn-aut-sei=井上 kn-aut-mei=忠男 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本康博 kn-aut-sei=岡本 kn-aut-mei=康博 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=4 article-no= start-page=143 end-page=150 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=コムギ赤カビ病の第二次伝染について　第2報 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=井上忠男 kn-aut-sei=井上 kn-aut-mei=忠男 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本康博 kn-aut-sei=岡本 kn-aut-mei=康博 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=4 article-no= start-page=157 end-page=161 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ペクチン驋酵に就て　第19報　ペクチンの分解中間物に対するポリガラクチュロナーゼの作用（2） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=3 article-no= start-page=128 end-page=130 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ペクチン驋酵に就て　第18報　ペクチンの分解中間物に対するポリガラクチュロナーゼの作用（1） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=2 article-no= start-page=79 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530915 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ペクチン驋酵に就て　第17報　Penicillium expansumの糖化型ポリガラクチユロナーゼ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=1 article-no= start-page=21 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ペクチン驋酵に就て　第16報　ポリガラクチュロナーゼの特異性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=武田晃 kn-aut-sei=武田 kn-aut-mei=晃 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=1 article-no= start-page=17 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ペクチン驋酵に就て　第15報　ペクチン質の分解とmacerationの関係（6） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=小沢潤二郎 kn-aut-sei=小沢 kn-aut-mei=潤二郎 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本賢一 kn-aut-sei=岡本 kn-aut-mei=賢一 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue= article-no= start-page=377 end-page=421 dt-received= dt-revised= dt-accepted= dt-pub-year=1933 dt-pub=19330425 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=本邦に於ける植物病害に關する文獻目錄（一九三二） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=西門義一 kn-aut-sei=西門 kn-aut-mei=義一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=松本弘義 kn-aut-sei=松本 kn-aut-mei=弘義 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本敏一 kn-aut-sei=岡本 kn-aut-mei=敏一 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An epidemiologically rare case of Vibrio vulnificus infection that occurred in October in an inland city of Japan kn-title=内陸地津山で発症した季節外れのVibrio vulnificus感染症 en-subtitle= kn-subtitle= en-abstract= kn-abstract=　A 68-year-old man with alcohol addiction, who lived in the suburbs of Tsuyama, an inland city located in northeast Okayama prefecture, was transported to the emergency unit of the Tsuyama Central Hospital in a state of cardiopulmonary arrest (CPA). Despite rigorous systemic investigation and treatment, the patient died 2 hours after arrival. After his death, Vibrio vulnificus was isolated from his blood culture. 　Vibrio vulnificus causes fatal infection in humans, usually only in areas located close to the sea where appropriate temperature and suitable salt concentration for its growth are available. Therefore, its occurrence is epidemiologically restricted ; in Japan, the western coastal areas, especially in summers, are reported to be the high-risk regions. This is a rare case because it occurred in a city approximately 50 kilometers from both the Sea of Japan and the Pacific coast of Okayama, and at the end of October in 2011. Economic development and distribution systems have made it possible to transport various food products from coastal areas or abroad to any place in a short time, such that these infections can potentially develop in areas other than expected. We should be aware of the increasing risk of Vibrio vulnificus infection during any season and at any place, especially in patients with abnormal liver function. en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name=萩谷英大 kn-aut-sei=萩谷 kn-aut-mei=英大 aut-affil-num=1 ORCID= en-aut-name=ShiotaSumiko en-aut-sei=Shiota en-aut-mei=Sumiko kn-aut-name=塩田澄子 kn-aut-sei=塩田 kn-aut-mei=澄子 aut-affil-num=2 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name=三好伸一 kn-aut-sei=三好 kn-aut-mei=伸一 aut-affil-num=3 ORCID= en-aut-name=KuroeYasutoshi en-aut-sei=Kuroe en-aut-mei=Yasutoshi kn-aut-name=黒江泰利 kn-aut-sei=黒江 kn-aut-mei=泰利 aut-affil-num=4 ORCID= en-aut-name=NojimaHiroyoshi en-aut-sei=Nojima en-aut-mei=Hiroyoshi kn-aut-name=野島宏悦 kn-aut-sei=野島 kn-aut-mei=宏悦 aut-affil-num=5 ORCID= en-aut-name=OtaniShinkichi en-aut-sei=Otani en-aut-mei=Shinkichi kn-aut-name=大谷晋吉 kn-aut-sei=大谷 kn-aut-mei=晋吉 aut-affil-num=6 ORCID= en-aut-name=SugiyamaJunichi en-aut-sei=Sugiyama en-aut-mei=Junichi kn-aut-name=杉山淳一 kn-aut-sei=杉山 kn-aut-mei=淳一 aut-affil-num=7 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name=内藤宏道 kn-aut-sei=内藤 kn-aut-mei=宏道 aut-affil-num=8 ORCID= en-aut-name=KawanishiSusumu en-aut-sei=Kawanishi en-aut-mei=Susumu kn-aut-name=川西進 kn-aut-sei=川西 kn-aut-mei=進 aut-affil-num=9 ORCID= en-aut-name=HagiokaShingo en-aut-sei=Hagioka en-aut-mei=Shingo kn-aut-name=萩岡信吾 kn-aut-sei=萩岡 kn-aut-mei=信吾 aut-affil-num=10 ORCID= en-aut-name=MorimotoNaoki en-aut-sei=Morimoto en-aut-mei=Naoki kn-aut-name=森本直樹 kn-aut-sei=森本 kn-aut-mei=直樹 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=2 en-affil= kn-affil=就実大学薬学部　病原微生物学 affil-num=3 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　衛生微生物化学 affil-num=4 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=5 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=6 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=7 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=8 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=9 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=10 en-affil= kn-affil=津山中央病院　救命救急センター affil-num=11 en-affil= kn-affil=津山中央病院　救命救急センター en-keyword=Vibrio vulnificus kn-keyword=Vibrio vulnificus END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=145 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of esophageal carcinosarcoma with a component of small cell carcinoma kn-title=小細胞癌成分を含む食道癌肉腫の１切除例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced a case of esophageal carcinosarcoma with a component of small cell carcinoma. The patient was a 73-year-old man. We administered chemotherapy of CDDP+VP-16, and performed an operation after 2 courses of this chemotherapy. Subtotal esophagectomy and reconstruction with the small intestine was performed. More than three years after resection, he remains alive and recurrence-free. There are few cases of esophageal carcinosarcoma and small cell carcinoma. We report this rare case herein. en-copyright= kn-copyright= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name=田辺俊介 kn-aut-sei=田辺 kn-aut-mei=俊介 aut-affil-num=1 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=白川靖博 kn-aut-sei=白川 kn-aut-mei=靖博 aut-affil-num=2 ORCID= en-aut-name=MaedaNaoaki en-aut-sei=Maeda en-aut-mei=Naoaki kn-aut-name=前田直見 kn-aut-sei=前田 kn-aut-mei=直見 aut-affil-num=3 ORCID= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name=大原利章 kn-aut-sei=大原 kn-aut-mei=利章 aut-affil-num=4 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name=野間和広 kn-aut-sei=野間 kn-aut-mei=和広 aut-affil-num=5 ORCID= en-aut-name=SakuramaKazufumi en-aut-sei=Sakurama en-aut-mei=Kazufumi kn-aut-name=櫻間教文 kn-aut-sei=櫻間 kn-aut-mei=教文 aut-affil-num=6 ORCID= en-aut-name=YanaiHiroyuki en-aut-sei=Yanai en-aut-mei=Hiroyuki kn-aut-name=柳井広之 kn-aut-sei=柳井 kn-aut-mei=広之 aut-affil-num=7 ORCID= en-aut-name=YamatsujiTomoki en-aut-sei=Yamatsuji en-aut-mei=Tomoki kn-aut-name=山辻知樹 kn-aut-sei=山辻 kn-aut-mei=知樹 aut-affil-num=8 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=猶本良夫 kn-aut-sei=猶本 kn-aut-mei=良夫 aut-affil-num=9 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=藤原俊義 kn-aut-sei=藤原 kn-aut-mei=俊義 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=2 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=3 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=4 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=5 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=6 en-affil= kn-affil=岡山大学病院　消化管外科 affil-num=7 en-affil= kn-affil=岡山大学病院　病理診断科 affil-num=8 en-affil= kn-affil=川崎医科大学　総合外科学 affil-num=9 en-affil= kn-affil=川崎医科大学　総合外科学 affil-num=10 en-affil= kn-affil=岡山大学病院　消化管外科 en-keyword=食道癌肉腫（esophageal carcinosarcoma） kn-keyword=食道癌肉腫（esophageal carcinosarcoma） en-keyword=小細胞癌（small cell carcinoma） kn-keyword=小細胞癌（small cell carcinoma） en-keyword=食道（esophagus） kn-keyword=食道（esophagus） END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=129 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Antibacterial efficacy of photocatalytic reaction on titanium dioxide-coated ceramic air filters kn-title=酸化チタン担持セラミックフィルターの光触媒反応による抗菌効果の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Titanium dioxide (TiO2) photocatalysis generates reactive oxygen species such as ・OH and ・O2-, which can effectively eliminate organic compounds. In the present study, we evaluated the antibacterial and antifungal effects of TiO2-coated ceramic air filters in both laboratory and hospital settings. Photocatalysis with the TiO2-coated ceramic filter effectively inactivated all 4 pathogenic organisms tested. Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. After the photocatalysis reaction for 4 h under UV-A (365nm, 250μW/㎠) irradiation, the percentage reductions of the number of E. coli, P. aeruginosa, S. aureus, C. albicans cells were 99.9%, 98.9%, 97.7% and 99.9%, respectively, indicating that Gram-negative bacteria are more susceptible to such photocatalysis than Gram-positive bacteria. Scanning electron microscopic analysis showed damage to the cytoplasmic membrane and cell wall by photocatalysis : consistent with above observations, the morphological change of Gram-negative E. coli was greater than that of Gram-positive S. aureus. 　Further, an air cleaner equipped with a TiO2-coated ceramic filter significantly decreased the number of bacteria floating in hospitals. 　These results indicate that air cleaners with TiO2-coated ceramic filters could be useful in reducing the incidence of nosocomial infections. en-copyright= kn-copyright= en-aut-name=NakaoMiyuki en-aut-sei=Nakao en-aut-mei=Miyuki kn-aut-name=中尾美幸 kn-aut-sei=中尾 kn-aut-mei=美幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医歯薬学総合研究科　病原細菌学 en-keyword=光触媒（photocatalysis） kn-keyword=光触媒（photocatalysis） en-keyword=酸化チタン担持セラミックフィルター（TiO2-coated ceramic air filters） kn-keyword=酸化チタン担持セラミックフィルター（TiO2-coated ceramic air filters） en-keyword=抗菌効果（antimicrobial effect） kn-keyword=抗菌効果（antimicrobial effect） en-keyword=院内感染（nosocomial infection） kn-keyword=院内感染（nosocomial infection） en-keyword=空気清浄機（air cleaner） kn-keyword=空気清浄機（air cleaner） END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100605 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Emerging trends in the etiology of enteric pathogens as evidenced from an active surveillance of hospitalized diarrhoeal patients in Kolkata, India en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: This study was conducted to determine the etiology of diarrhoea in a hospital setting in Kolkata. Active surveillance was conducted for 2 years on two random days per week by enrolling every fifth diarrhoeal patient admitted to the Infectious Diseases and Beliaghata General Hospital in Kolkata. Results: Most of the patients (76.1%) had acute watery diarrhoea in association with vomiting (77.7%) and some dehydration (92%). Vibrio cholerae O1, Rotavirus and Giardia lamblia were the important causes of diarrhoea. Among Shigella spp, S. flexneri 2a and 3a serotypes were most predominantly isolated. Enteric viruses, EPEC and EAEC were common in children <5 year age group. Atypical EPEC was comparatively higher than the typical EPEC. Multidrug resistance was common among V. cholerae O1 and Shigella spp including tetracycline and ciprofloxacin. Polymicrobial infections were common in all age groups and 27.9% of the diarrhoea patients had no potential pathogen. Conclusions: Increase in V. cholerae O1 infection among <2 years age group, resistance of V. cholerae O1 to tetracycline, rise of untypable S. flexnerii, higher proportion of atypical EPEC and G. lamblia and polymicrobial etiology are some of the emerging trends observed in this diarrhoeal disease surveillance. en-copyright= kn-copyright= en-aut-name=NairGopinath Balakrish en-aut-sei=Nair en-aut-mei=Gopinath Balakrish kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=RamamurthyThandavarayan en-aut-sei=Ramamurthy en-aut-mei=Thandavarayan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=BhattacharyaMihir Kumar en-aut-sei=Bhattacharya en-aut-mei=Mihir Kumar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KrishnanTriveni en-aut-sei=Krishnan en-aut-mei=Triveni kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GangulySandipan en-aut-sei=Ganguly en-aut-mei=Sandipan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SahaDhira Rani en-aut-sei=Saha en-aut-mei=Dhira Rani kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=RajendranKrishnan en-aut-sei=Rajendran en-aut-mei=Krishnan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MannaByomkesh en-aut-sei=Manna en-aut-mei=Byomkesh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=GhoshMrinmoy en-aut-sei=Ghosh en-aut-mei=Mrinmoy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TakedaYoshifumi en-aut-sei=Takeda en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=2 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=3 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=4 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=5 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=6 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=7 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=8 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=9 en-affil= kn-affil=Infectious Diseases and Beliaghata General Hospital affil-num=10 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=11 en-affil= kn-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India, NICED END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=2 article-no= start-page=143 end-page=154 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Attenuated Sensory Deprivation-induced Changes of Parvalbumin Neuron Density in the Barrel Cortex of FcγRllB-deficient Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of FcγRllB protein in parvalbumin- containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in FcγRllB-deficient mice (FcγRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between FcγRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcγRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcγRllB contributes to sensory experience-regulated expression of PV. en-copyright= kn-copyright= en-aut-name=WatanabeMakiko en-aut-sei=Watanabe en-aut-mei=Makiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YokobayashiEriko en-aut-sei=Yokobayashi en-aut-mei=Eriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UsuiShinichi en-aut-sei=Usui en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SujiuraHiroko en-aut-sei=Sujiura en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Koyodai Hospital affil-num=4 en-affil= kn-affil=Department of Psychiatry, Kawasaki Medical University affil-num=5 en-affil= kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=7 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=8 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University en-keyword=parvalbumin kn-keyword=parvalbumin en-keyword=fast-spiking interneurons kn-keyword=fast-spiking interneurons en-keyword=FcγRllB kn-keyword=FcγRllB en-keyword=barrel cortex kn-keyword=barrel cortex en-keyword=sensory deprivation kn-keyword=sensory deprivation END start-ver=1.4 cd-journal=joma no-vol=147 cd-vols= no-issue= article-no= start-page=63 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110625 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research trends concerning school children's change of eating behavior during school lunches and their formation of sense of eating with company kn-title=学校給食における児童の食行動の変容と食事観の形成に関する研究動向 en-subtitle= kn-subtitle= en-abstract= kn-abstract=本稿の目的は，学校給食の機能に着目し，児童の食行動や食事観の形成に影響を与える要因についての研究動向をまとめ，現代における｢共食｣を目指した給食指導の留意点を明らかにすることである。先行研究は次の三つに分類･整理した。一つめは，児童の給食指導を担う教師の影響を探究したものである。二つめは，児童の発達段階の影響を調査したもので，三つ目は食環境の影響に焦点を当てたものである。先行研究の動向から明らかになったことは，二点ある。一点目は，児童の食事に対する意識を捉える場合は調査票を用いた量的調査を，児童の食行動の変容を追究する場合は質的調査を各研究者が利用していたことである。二点目は，児童の食事観は家庭だけでなく給食においても様々な影響を受け，形成されるということである。したがって，教師や研究者は，｢共食｣を目指した給食指導に，児童の社会化を促す役割が含まれているということを認識する必要がある。 en-copyright= kn-copyright= en-aut-name=NobeMasao en-aut-sei=Nobe en-aut-mei=Masao kn-aut-name=野邊政雄 kn-aut-sei=野邊 kn-aut-mei=政雄 aut-affil-num=1 ORCID= en-aut-name=OkamotoMai en-aut-sei=Okamoto en-aut-mei=Mai kn-aut-name=岡本真依 kn-aut-sei=岡本 kn-aut-mei=真依 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院教育学研究科社会･言語教育学系社会科教育講座 affil-num=2 en-affil= kn-affil=岡山大学大学院教育学研究科 en-keyword=学校給食 kn-keyword=学校給食 en-keyword=共食 kn-keyword=共食 en-keyword=児童 kn-keyword=児童 en-keyword=食行動 kn-keyword=食行動 en-keyword=食事観 kn-keyword=食事観 END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=1-2 suppl article-no= start-page=9 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Seasonal level of hemoagglutinin inhibitinlt and its 2-mercaptoethanol sensitive antibody in the sera of swine (Epidemiological Study on Japanese Encephalitis, 67) kn-title=豚及び住民の日本脳炎HI抗体および2-ME感受性抗体陽性率 （日本脳炎の疫学的研究 67） en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seasonal level of hemoagglutinin inhibiting and its 2 -mercaptoethanol sensitive antibody in the sera of swine were researched and the following results were obtained. 1. The positive rate of hemoagglutination inhibit reaction (HI reaction) on swine showed 100% at maximum in the middle of September. 1980. The positive rate of 2-ME sensitive antibody showed the titer of over 1 : 40 with all swine examined in the middle of August, 1980. 2. The positive rate of HI reaction of inhabitants at Mukaiyama in Kurashiki City was 76.0% (on 8th in July, 1980) indicating the rather big decrease being compared with annual value of 90.6%, in 1976. Date indicated that increase In JE virus in swine as source of infection thought to be a vector of JE, caused a genuine case of JE, in 1980, as described below. 3. Higher positive rate of HI reaction and 2-ME sensitive positive rate of swine were observed in 1980. 4. One patient who suffered from JE was found In Kurashiki City in 1980. 5. Henceforth and continuously, Japanese Encephalitis should be investigated, above all on its occurance order with the number or Ct or the positive rate of hemoagglutination inhibit reaction in inhahitants and swine, etc. considering that J.E. has a high lethality rate and often leaves the terrible J. E. residue to patients. en-copyright= kn-copyright= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=緒方正名 kn-aut-sei=緒方 kn-aut-mei=正名 aut-affil-num=1 ORCID= en-aut-name=MeguroTadamichi en-aut-sei=Meguro en-aut-mei=Tadamichi kn-aut-name=目黒忠道 kn-aut-sei=目黒 kn-aut-mei=忠道 aut-affil-num=2 ORCID= en-aut-name=HirotaNoboru en-aut-sei=Hirota en-aut-mei=Noboru kn-aut-name=広田昇 kn-aut-sei=広田 kn-aut-mei=昇 aut-affil-num=3 ORCID= en-aut-name=MatuiYoshinori en-aut-sei=Matui en-aut-mei=Yoshinori kn-aut-name=松井義典 kn-aut-sei=松井 kn-aut-mei=義典 aut-affil-num=4 ORCID= en-aut-name=SatoYukinori en-aut-sei=Sato en-aut-mei=Yukinori kn-aut-name=佐藤征紀 kn-aut-sei=佐藤 kn-aut-mei=征紀 aut-affil-num=5 ORCID= en-aut-name=AikoHiromi en-aut-sei=Aiko en-aut-mei=Hiromi kn-aut-name=愛甲博美 kn-aut-sei=愛甲 kn-aut-mei=博美 aut-affil-num=6 ORCID= en-aut-name=IshidaTatsuo en-aut-sei=Ishida en-aut-mei=Tatsuo kn-aut-name=石田立夫 kn-aut-sei=石田 kn-aut-mei=立夫 aut-affil-num=7 ORCID= en-aut-name=HiramatsuMuneshige en-aut-sei=Hiramatsu en-aut-mei=Muneshige kn-aut-name=平松宗成 kn-aut-sei=平松 kn-aut-mei=宗成 aut-affil-num=8 ORCID= en-aut-name=OtokuraTakashi en-aut-sei=Otokura en-aut-mei=Takashi kn-aut-name=乙倉巍 kn-aut-sei=乙倉 kn-aut-mei=巍 aut-affil-num=9 ORCID= en-aut-name=TakagiKanji en-aut-sei=Takagi en-aut-mei=Kanji kn-aut-name=高木寛治 kn-aut-sei=高木 kn-aut-mei=寛治 aut-affil-num=10 ORCID= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name=岡本旭 kn-aut-sei=岡本 kn-aut-mei=旭 aut-affil-num=11 ORCID= en-aut-name=NishuTakeo en-aut-sei=Nishu en-aut-mei=Takeo kn-aut-name=二宗壮夫 kn-aut-sei=二宗 kn-aut-mei=壮夫 aut-affil-num=12 ORCID= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=角南重夫 kn-aut-sei=角南 kn-aut-mei=重夫 aut-affil-num=13 ORCID= en-aut-name=JitsunariFumihiko en-aut-sei=Jitsunari en-aut-mei=Fumihiko kn-aut-name=実成文彦 kn-aut-sei=実成 kn-aut-mei=文彦 aut-affil-num=14 ORCID= en-aut-name=MorishitaTakayuki en-aut-sei=Morishita en-aut-mei=Takayuki kn-aut-name=森下喬之 kn-aut-sei=森下 kn-aut-mei=喬之 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=7 en-affil= kn-affil=岡山県環境保健センター affil-num=8 en-affil= kn-affil=岡山県環境保健センター affil-num=9 en-affil= kn-affil=岡山保健所 affil-num=10 en-affil= kn-affil=岡山県衛生部 affil-num=11 en-affil= kn-affil=岡山県衛生部 affil-num=12 en-affil= kn-affil=岡山県衛生部 affil-num=13 en-affil= kn-affil=川崎医科大学・公衆衛生学教室 affil-num=14 en-affil= kn-affil=岡山大学教育学部・養護教育 affil-num=15 en-affil= kn-affil=森下病院 END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=129 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic surgery for mesenteric Castleman's disease kn-title=腹腔鏡下に摘出しえた上行結腸間膜発生のCastleman病の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report herein a case of mesenteric Castleman's disease which was confirmed on pathology. A 60-year-old man was admitted to our hospital complaining of abdominal pain. On the physical examination, there was no palpable mass. Computed tomography findings and magnetic resonance imaging revealed a well circumscribed, lobulated round mass on the right side of the superior mesenteric vein. Laparoscopic surgery for the mesenteric tumor was carried out to obtain a definite diagnosis and treatment. In the operative field, the mass was located on the ascending colic mesentery and measured about 3 cm in size. It was solid and surrounded by a thin fibrous capsule. The histological diagnosis of the mesenteric tumor was hyaline vascular type Castleman's disease. The postoperative course of the patient was uneventful, and he was discharged on the 10th postoperative day. en-copyright= kn-copyright= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=1 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚真哉 kn-aut-sei=大塚 kn-aut-mei=真哉 aut-affil-num=2 ORCID= en-aut-name=TomodaJun en-aut-sei=Tomoda en-aut-mei=Jun kn-aut-name=友田純 kn-aut-sei=友田 kn-aut-mei=純 aut-affil-num=3 ORCID= en-aut-name=FujiwaraKeishi en-aut-sei=Fujiwara en-aut-mei=Keishi kn-aut-name=藤原敬士 kn-aut-sei=藤原 kn-aut-mei=敬士 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　内科 affil-num=4 en-affil= kn-affil=光生病院　内科 en-keyword=結腸間膜 (mesocolon) kn-keyword=結腸間膜 (mesocolon) en-keyword=Castleman病 (Castleman's disease) kn-keyword=Castleman病 (Castleman's disease) en-keyword=腹腔鏡手術 (laparoscopic surgery) kn-keyword=腹腔鏡手術 (laparoscopic surgery) END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=1 article-no= start-page=33 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Investigation of laparoscopic therapy in 56 cases of duodenal ulcer perforation kn-title=十二指腸潰瘍穿孔に対する治療法の適応についての検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Although conservative therapy has been acceptable as the first-line therapy for duodenal ulcer (DU) perforations, surgical therapies are known to have certain advantages. We investigated the indications for laparoscopic (LS) or open surgery (OS) or conservative therapy (CoT) among 56 DU perforation cases over 5 years. Methods: 31 LSs, 22 OSs and 5 CoTs were analyzed for patient's physical and surgical factors and clinical course. Results: Mean age was 51.6. Male/female ratio was 49/9. Survival ratio was 98%. Although the hospital stay (10.9 vs 19.5 days) and analgesic administrations (1.9 vs 4.6 days) were significantly shorter in LS than OS, almost all OS patients were in serious condition as evidenced by longer waiting time before treatment, stronger pain, bigger hole of perforation, more ascites accumulation and higher morbidity of complications. Two cases of multisurgery were experienced in both LS and OS groups due to leakage of seam, abscess formation, relapsed ulcer or idiopathic intestinal perforation. LS is a therapy more widely usable and more beneficial than the other two. Conclusion: LS, a minimally invasive surgery for DU perforation, should be considered as a first-line standard therapy because of significant advantages such as shorter hospital stay. OS or CoT may be selected when appropriate. en-copyright= kn-copyright= en-aut-name=IshidoNobuhiro en-aut-sei=Ishido en-aut-mei=Nobuhiro kn-aut-name=石堂展宏 kn-aut-sei=石堂 kn-aut-mei=展宏 aut-affil-num=1 ORCID= en-aut-name=TamuraRyuji en-aut-sei=Tamura en-aut-mei=Ryuji kn-aut-name=田村竜二 kn-aut-sei=田村 kn-aut-mei=竜二 aut-affil-num=2 ORCID= en-aut-name=OkamotoTakahiro en-aut-sei=Okamoto en-aut-mei=Takahiro kn-aut-name=岡本貴大 kn-aut-sei=岡本 kn-aut-mei=貴大 aut-affil-num=3 ORCID= en-aut-name=KadowakiYoshihiko en-aut-sei=Kadowaki en-aut-mei=Yoshihiko kn-aut-name=門脇嘉彦 kn-aut-sei=門脇 kn-aut-mei=嘉彦 aut-affil-num=4 ORCID= en-aut-name=MoriTakashi en-aut-sei=Mori en-aut-mei=Takashi kn-aut-name=森隆 kn-aut-sei=森 kn-aut-mei=隆 aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=2 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=3 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=4 en-affil= kn-affil=神戸赤十字病院　外科 affil-num=5 en-affil= kn-affil=神戸赤十字病院　外科 en-keyword=十二指腸潰瘍穿孔 (duodenal ulcer perforation) kn-keyword=十二指腸潰瘍穿孔 (duodenal ulcer perforation) en-keyword=腹腔鏡手術 (laparoscopic surgery) kn-keyword=腹腔鏡手術 (laparoscopic surgery) en-keyword=保存療法 (conservative therapy) kn-keyword=保存療法 (conservative therapy) END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=3 article-no= start-page=496 end-page=503 dt-received= dt-revised= dt-accepted= dt-pub-year=1942 dt-pub=19420331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Über einen Fall von Brustdrüsenkarzinom' bei männlichem Geschlecht und eine statistische Beobachtnng des Brustdrüsenkarzinoms bei Männern in Japan kn-title=男子乳癌ノ1例及ビ本邦男子乳癌ノ統計的觀察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) Verf. berichtet über einen Fall von rechtsseitigen ulcerösem Brustdrüsenkarzinom (Carcinoma simplex) bei einem 62 jährigen Manne. 2) Das Mammakarzinom ist bei Männern eine äusserst seltene Erscheinung, unter den sämtliehen 80 Fällen des Brustdrüsenkarzinoms welche im Laufe der letzten 10 Jahre in unserer Tsuda-Klinik behandelt wordcn waren, war nur ein Fall bei männiichem Geschlecht vorgekommen, das macht also 1,25% aller Mammakarzinome unserer Klinik aus. Auch nach manchen, spezifisch klinischen Statisken weist es eine Frequenz von ca. 1% der ganzen Mammakarzinome auf. 3) Aus der einheimischen Literatur hat der Verf. insgesamt 34 zuverlässige Fälle von männlichem Mammakarzinom ausgewählt und daren eine statistische Beobachtung angestellt. 4) Das vorliegende Karzinom entwickelt sich bei Männern in der Regel 5-10 Jahre später als bei Frauen und am häufigsten im 50., durchschnittlich im 56,6 Jahr. 5) Die befallene Seite der Mamma wurde in annähernd gleicher Häufigkeit nachgewiesen. 6) Die Frist von der Entstehung der Tumoren bis zur Operation betrug in 8 Fällen länger als 2 Jahre und darunter, in 19 Fällen läager als 2 Jahre, in den übrigen 8 Fällen war sie nicht bekannt. 7) Über die Pathogenese ist noch keine Einheit erzielt. Es interessiert uns aber, dass es viele Fälle gab, in denen wir einen Übergang des benignen zum malignen Tumor annehmen müssen. 8) Das Karzinom nahm seinen Sitz in den meisten Fällen im zentralen Abschnitt der Mamma ein und war meistens hühnerei- resp. faustgross. Geschwürsbildung liess sich bei 46% der Fälle feststellen. 9) Was die histopathologischen Befunde anbetrifft, so wurde Adenokarzinom am häufigsten, d.h. in den 11 Fällen (36,6%) beobachtet, ihm folgte der Skirrhus mit 8 Fällen (26,6%). en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=岡本繁 kn-aut-sei=岡本 kn-aut-mei=繁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=4 article-no= start-page=596 end-page=612 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Über die primare Lungen- und Periproktalaktinomykose kn-title=原發性肺放線状菌症竝ニ放線状菌性肛門周圍膿瘍ニ就テ en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) Ein 22 jähriger Seemann. Seitdem er im Mai 1938 dem Stellungsbefehl Folge geleistet hatte, arbeitete er auf einem von der Regierung gecharterten Schiff an der Abladung der Militärpferde und führte so von Tag zu Tag unsauberes Leben. Im September verliess er wegen Beriberi das Schiff und wurde in ein Krankenhaus aufgenommen. Von dem nächsten Tage an trat ein heftiger Schmerz am unteren Teil des Prozessus Xyphoideus ein. Zu dieser Zeit hatte er Husten und entleerte Sputa, wovon er sich jedoch gar nicht bekümmerte. Am Vorderthorax nahmen indes Rötung der Haut, Schwellung und Schmerz allmählich an Stärke zu, am Ende desselben Jahres entstanden schliesslich Fisteln, woraus dickflüssige Eiter herauskamen. Im Anfang des nachsten Jahres wurde er in einem Krankenhause unter der auf Röntgenbild gestellten Diagnose als eine Lungentuberkulose behandelt. Da es sich aber immer weiter verschlimmert hatte, wurde er schliesslich im März 1939 mit den Hauptklagen über zahlreiche Fistelbildun gen an der vorderen Thoraxwand und einen heftigen Schmerz im Thorax in unsere Klinik eingeliefert. Die sehr charakteristischen Drusen oder die Tuberkelbazillen liessen sich nicht im Sputum, sondern die Drusen in der Eiterflüssigkeit nachweisen. Auf Grund der Reinkultur wurde es ferner festgestellt, dass die aufgefundenen Strahlenpilzen zu einer Art der fakultativen Anaerobien gehörten. Im Anchluss an diesen Befund sprachen die Befunde der Röntgenuntersuchung der Thoraxgegend dafür, dass es sich um eine primäre Lungenaktinomykose handelte, weiche die Partie von der rechten Lungenpforte bis zum Unterlappen angriff. Der Verf. berichtet über die vollige Heilung des Kranken, die er durch Inzision der Abezesse, Auskratzung, Aufstreuung von Jodformpulvern, fortgesetzte Darreichung grösserer Dosen von Jodkalium (bis zu 6g), Injektion von Aktisol, Röntgenbestrahlung (Abstand: 30cm, 150γ; Intervall: 3 Tage-1 Woche; im Laufe von 58 Tagen 12mal bestrahlt) erzielen konnte. Schliesslich fügt er noch Besprechung über dieses Krankneitsbild hinzu. Die vorliegende Krankheit bevorzugt gerade wie der andersartigen Aktinomykosen junge Männer von 20-30 Jahren (befallen wurden die Männer ca. 2 oder 3 fach mehr als die Frauen) und zwar entwickelt sich am häufigsten am rechten Unterlappen. Verhaltnismässig selten iet Lungenaktinomykose: sie beträgt in der Frequenz nur 15-20% der gesammten Fälle. Der Verf. hebt besonders hervor, dass man bei der Stellung der Differenzialdiagnose gegen die Lungentuberkulose sehr vorsichtig sein soil. Röntgenologisch bietet die Luugenaktinomykose keinen eigentümlichen Schatten dar, im Vergleich zur Lungentuberkulose treten jedoch bei ihr ziemlich derbe und dicke Schatten, welche von Peribronchitis herrühren, in die Erscheinung. Ausserdem kann man bei aufmerksamer Beobachtung auch das Bild einer im Früstadium auftretenden Verdickung der Pleura, das Bild einer sich rapid und hochgradig einstellenden retraktiven Schrumpfung der Brusthöhle und das der Ossifikationsperiostitis der Rippen erkennen. Für zweifelhaft Falle empfiehlt der Verf. auch die Anstellung der Kutanreaktionen. 2) Ein 34 jähriger Angestellter. Bei diesem Pat. fehlten im ganzen Verlaufe der Krankheit hohes Fieber und Storungen des Magen-Darmkanals vollständig. Die Symp. tome gleichen vollkommen denen der haufig vorkommenden tuberkulösen oder unspezifischen Periproktitis. Durch die Inzision einer daumengross indurierten Stelle auf der rechten Seite der Analöffnung wurden einige zehn Pilzdrusen nachgewiesen, welche den dicken Eiter fast vollständig einnahmen. Die Reinkultur ergab, dass die Pilze obligatanaerob waren. en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=岡本繁 kn-aut-sei=岡本 kn-aut-mei=繁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=4 article-no= start-page=565 end-page=591 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchungen über die Ursachen der akuten Pankreasnekrose. (IV. Mitteilung) Experimentelle und klinische Studien über die Abfliessung von Pankreassaft in die Gallenwege kn-title=急性膵臟壞死ノ成因ニ關スル實驗的研究（第4編）膵液膽道内逆流ノ實驗的竝ニ臨牀的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clairmont und v. Haberer beobachten 1910 einen Fall, der das Sypmtom akuter Peritonitis mit galligem Exsudate darbot. Da bei der Obduktion keine Perforation an den Gallenwegen zu finden war, belegten sie diesen Fall mit dem Namen "perforationslose gallige Peritonitis". Anschliessend an diese Veröffentlichung wurden im Laufe der Jahre eine grosse Anzahl analoger Fälle beschrieben und es entspann sich eine so lebhafte Diskussion über den Entstehungsmechanismus dieser Krankheit, dass eine Einigung daruber noch lange nicht zu erwarten ist. Seitdem aber A. Blad 1918 eine neue Theorie der Pankreassaftstauung für die Erklärung dieser Frage aufgestellt hatte, wurde seine Annahme von Schönbauer, Westphal u.a. in Bezug auf die Pankreasfermente nachgeprüft und man konnte dabei durch Einführung der Pankreasfermente nicht nur eine Verdauungsnekrose der Gallenblasenwand hervorrufen, sondern in einigen Fällen sogar die perforationslose gallige Peritonitis erzeugen. Ferner haben Gundermann, Westphal, Ruppanner, Dziembowsky, Brackerg, Popper u.a. in der Gallenblasengalle eine abnorme Vermehrung von Diastase nachweisen. Der Erscheinungsmechanismus der Pankreasfermente in der Galle ist jedoch von den verschiedenen Beobachtern verschieden festgestellt und gedeutet worden. Während einige Forscher annehmen, dass die Diastase von der Leber abgesondert wird, wird sie von anderen in die Blut- oder Lymphwege eingebracht. Wieder andere betonen sogar die Möglichkeit der Abfliessung des Pankreassaftes in die Gallenwege. Ich habe nur zur Feststellung der Wirkungen, die der Pankrassaft auf die Gallenwege und vor allem auf die Gallenblase ausübt, bei einer Gruppe der Versuchstiere experimentell die Gallenblase an ihrem Hals unterbunden, bei einer anderen eine Ligatur an den Ductus choledochus angelegt und dann den beiden Gruppen je ein Präparat von Pankreassekret resp. Pankreasfermenten eingeführt. Daneben habe ich auch den Versuch ausgeführt, den Ductus pancreaticus mit der Gallenblase in Kommunikation zu bringen. Ferner habe ich bei 35 Patienten, die wegen Gallensteinkrankheit in unsere Tsuda-Klinik aufgenommen worden waren, in der durch eine Punktion intra operationem gewonnenen Galle den Diastasewert bestimmt und auch die in der Galle der Gallenfistel befindlichen Pankreasfermente fraktionierend untersucht. Bei Versuchshunden habe ich sodann die akute Pankreasnekrose hervorgerufen und die im Blutserum sowohl wie in der Galle befindliche. Diastase fraktionierend aufgefangen und an beiden Diastasen ergleichende Untersuchung angestellt. Am Ende werde ich noch uber einen interessanten klinischen Fall berichten, in dem der Anfall der akuten Pankreasnekrose bei einem Gallensteinkranken wiederholend aufgetreten war. Meine Ergebnisse waren wie folgende: 1. Fälle, in denen die Pankreasfermente nach operativem Cysticusverschluss in die Gallenblase eingeführt wurden. a) Bei der Einführung physiologischer Kochsalzlösung wurden ausser einer Dilatation der Gallenblasenwand keine histologischen Veaänderungen beobachtet. b) Bei der Einführung von 5% Protamylaselösung in der Dosis von 1-5cc entstand in 1/3 der sämtlichen 11 Fälle perforationslose gallige Peritonitis. Histologisch liess sich bis zu 65% eine vollige Nekrose aller Schichten nachweisen. Ausserdem wurden in der Mehrzahl der Fälle Blutungen und Zellinfiltrationen festgestellt. c) Bei der Einfuhrung von 10-40% Diastaselösung in der Dosis von 2cc wurde die Gallenblase in der Regel am leichtesten geschädigt, indem ein Peritonealexsudat in keinem Fall beobachtet wurde und nur Blutungen und Zellinfiltrationen in die Erscheinung traten. en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=岡本繁 kn-aut-sei=岡本 kn-aut-mei=繁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=4 article-no= start-page=547 end-page=564 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchungen über die Ursachen der akuten Pankreasnekrose. (III. Mitteilung) Verbindungsversuche des Ductus choledochus mit dem Ductus pancreaticus durch Duodenum kn-title=急性膵臟壞死ノ成因ニ關スル實驗的研究（第3編）經十二指腸的總輸膽管輸膵管連絡實驗 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bei Hunden mündet der accessorische Pankreasgang in die Einmündungsstelle des Choledochus ein and davon etwas entfernt findet slch die Einmündungsstelle des Hauptgangs des Pankreas, so dass man für das Experiment von gemeinsamer Mundung die beiden Ductus kunstlich in Verbindung bringen muss. Nach Anbringung eines Längsschnittes an das Duodenum wurde der Ductus choledochus mittelst eines Glasröhrchens mit dem Ductus pancreaticus verbunden, um die Veränderungen des Pankreas sowie des Gallenganges zu untersuchen, and zwar unter der Vorstellung, dass es sich hier um den Fall einer Einklemmung von Gallensteinen in der Papilla duodeni beim menschlichen Körper handle. Zur Beobachtung wurde nach der Operation eine Gruppe der Versuchstiere auf einem Versuchsstativ befestigt, eine andere auf sich überlassen. 1) Unter den 7 Fallen der befestigten Hunde lieferten 3 Fälle das Bild akuter Pankreasnekrose, 2 Fälle das Bild akuter Pankreatitis, 1 Fall eine Degeneration des Pankreas, 1 Fäll das Bild eines akuten Pankreasodems. Bei der Gallenblase wurde eine völlige Nekrose aller Schichten in 5 Fällen, eine Nekrose des Schleimhautepithels in 2 Föllen festgestellt. Ferner gab es zwei Fälle, in denen der eine durch perforationslose gallige Peritonitis den Tod fand, der andere infolge von Gallenblasenperforation 19 Stunden nach der Operation verendete; in beiden Fällen zeigte das Pankreas ein leichtgradiges Ödem, sonst keine Veränderung. Aus alledem geht hervor, dass die Überfliessung dee pankreatischen Saftes in die Gallenblase früher auftritt als die der Galle in den Pankreasgang. 2) Die 7 Fälle, die auf sich selbst überlassen wurden, blieben länger am Leben (2-8 Tage); 2 Fälle davon hat der Verf. zum Tod gefuhrt. Was die Veränderungen des Pankreas anbetrifft, so traten sie in diesen 7 Fällen im Vergleich zu den vorhergehenden in viel leichterem Masse auf; hier wurde namentlich kein Bild der Nekrose beobachtet, akute Pankreatitis liens Bich nur in einem Fäll feststellen, in einem anderen Fall waren die Veränderungen nicht erheblich, in den ubrigen 5 Fällen wurde bloss eine dissozierte Degeneration konstatiert. An der Gallenblase traten hingegen Veränderungen in so starkem Masse wie in ded oben erwähnten befestigten Fällen in die Erscheinung: eine völlige Nekrose alter Schichten wurde in 5 Fällen, Nekrose des Schleimhautepithels in 2 Fallen, gallige Peritonitis mit Perforation in 2 Fällen. ohne Perforation in 1 Fall beobachtet. Diese Erscheinung, dass trotz der intensiven Veränderung der Gallenblase die Degeneration des Pankreas nicht nur in leichterem Grade, sondern auch nur in wenigeren Fällen eintrat, kommt daher, dass infolge des starken Drucker der Pankreassekretion der Pankreassaft in die Gallenblase überfliesst. 3) Aus den oben geschilderten Ergebnissen ist zu ersehen, dass bei dem postoperativen Zustandekammen gemeinsamer Mündung von beiden Ductus der Sekretionsdruck des Pankreas den Gallengangsdruck ubertrifft und infolgedessen eine Gegenströmung des Pankreassaftes in die Gallenwege oder sogar in die Gallenblase stattfindet, wodurch Verdauungsnekrose, gegebenenfalls gallige Peritonitis mit oder ohne Perforation und pankreatische Peritonitis bedingt wird. Wenn dabei der Druck der Gallenblase sehr gross ist oder von aussen irgendein Druck hinzutritt (z. B. Bauchpresse beim Heulen oder Erbrechen), so erscheint die Annahme nahe liegend, dass die mit dem Pankreassaft durchmischten Galle verkehrt in den Pankreasgang zuruckfliesst und akute Pankreasnekrose hervorruft. en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=岡本繁 kn-aut-sei=岡本 kn-aut-mei=繁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=3 article-no= start-page=377 end-page=411 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchungen über die Ursachen der akuten Pankreasnekrose. (II. Mitteilung) Druckmessung des Ductus choledochus und pancreaticus auf experimentellem Wege kn-title=急性膵臟壊死ノ成因ニ關スル實驗的研究（第2編）膽管膵管系統ノ壓力測定實驗 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Zum Experiment dienten Hunde von ungefähr 15kg Gewicht, die gut ernährt und dressiert werden. Eine kleine Inzision wurde am Ductus choledochus vorgenommen und eine Hepaticuskanüle wurde dann in der Richtung nach der Leber, die Oddische Kanüle in der Richtung nach dem Duodenum eingeführt. An die beiden Kanülen wurde je ein Gummirohr angebracht, um die beiden ausserhalb der Bauchwand durch ein U-förmiges Rohr zu verbinden. Diese Einrichtung diente dazu, dass die Galle ausser der Zeit der Experimente stets ins Duodenum abfliesst. Mit dem Ductus pancreaticus wurde die Pawlowsche Fistel, oder durch Einfü hrung einer Kanüle in den Hauptgang des Pankreas eine Paukreasgangfistel gebildet. Die erstere ist fur prolongierte Untersuchungen geeignet, die letztere für ein unmittelbar nach der Operation auszuführendes Experiment sehr gut anwendbar. Da der pankreatische Saft stets nach aussen abgeflossen war, wurde den Versuchshunden täglich Protamylase verabreicht. Die Hunde, die 7-10 Tage nach der Operation wieder zu Kräften kamen, wurden sodann auf einem Befestigungsstativ fixiert, das U-förmige Rohr wurde jetzt ausgelöst und das Druckmessungsrohr wurde verbunden. In die Oddische Kanule habe ich aus der Mariotteschen Flasche unter einem Wasserdruck von 400mm 10-12 Tropfen in jeder Minute eingetropfelt, um die Schwankungen des Druckes, welche infolge von Variationen des Tonus des Oddischen Muskels auftraten, an der Graduierung des angebrachten Messungsrohrs gelesen. Der Druck des Ductus choledochus stellte den Gesamtbetrag der sämtlichen Drucke dar, die die Gallensekretion, die Entspannung und Kontraktion der Gallenblase, und die Druckwechselung des Bauches hervorbrachten. Der Druck des Ductus pancreaticus war nichts anderes als der Druck der Pankreassekretion und wurde nur an dem. Hauptgang des Pankreas gemessen. Der Druck des Ductus pancreaticus accessorius wurde auf sich gelassen, da er verschwindend klein und seine Messung daher bedeutungslos war. Die oben geschilderte Versuchseinrichtung hatte den Zweck, die Abflussrichtung der Galle und des Pankreatischen Saftes bei Einklemmung der Gallensteine in der Vaterschen Papille oder bei dem Krampf des Oddischen Muskels festzustellen. 1) Bei Verabreichung von Wasser. Nach 24 stündiger Inanition wurde Wasser in der Dosis von 500cc verabreicht. Der Ductus pancreaticus zeigte dabei im Laufe von durchschnittlich 25 Minuten den höchsten Druck von 378mm H(2)O (Drucksteigerung betrug 280mm H(2)O), der Ductus choledochus im Laufe von 24 Minuten 250mm H2O (Drucksteigerung 77mm H(2)O). 2) Bei Verabreichung von Rinderfleisch. Der Ductus pancreaticus lieferte im Verlauf von 25 Minuten den höchsten Druck von 420mm H(2)O (Drucksteigerung 355mm H(2)O), der Ductus choledochus im Verlauf von 32 Minuten 355mm H(2)O (Drucksteigerung 140mm H(2)O). 3) Bei Verabreichung von Reis. Beim Ductus pancreaticus stieg während 25 Minuten der Druck bis zu 318mm H(2)O (Druckerhöhung 160mm H(2)O), beim Ductus choledochus während 27 Minuten bis zu 287mm H(2)O (Drucksteigerung 103mm H(2)O). 4) 2 Stunden nach der Fütterung stieg beim Ductus pancreaticus im Verlauf von 45 Minuten der Druck bis zu 399mm H(2)O, beim Ductus choledochus im Laufe von 47,8 Minuten bis zu 367mm H(2)O. 5) 15-24 Stunden nach der Fütterung gelangte der Ductus pancreaticus im Laufe von durchschnittlich 81 Minuten zum höchsten Druck von 399mm H(2)O, der Ductus choledochus im Laufe von 83 Minuten zum Druck von 323mm H(2)O. Im Vergleich zum Fall von 2 Stunden nach der Fütterung brachte es hier doppelt so viel Zeit zur Erreichung des höchsten Druckes, was eine Herabsetzung des Druckes verriet. en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=岡本繁 kn-aut-sei=岡本 kn-aut-mei=繁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=3 article-no= start-page=363 end-page=376 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchungen über die Ursachen der akuten Pankreasnekrose. (I. Mitteilung) Über die Wechselbeziehungen zwischen dem Ductus choledochus und dem Ductus pancreaticus an der Einmündungsstelle ins Duodenum kn-title=急性膵臟壞死ノ成因ニ關スル實驗的研究（第1編）總輸膽管ト輸膵管トノ十二指腸開口部ニ於ケル相關々係 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seit der Veröffentlichung von Opie über die Befunde eines Obduktionsfalles, in dem infolge von Einklemmung kleiner Gallensteine in der Papille eine akute Pankreasnekrose aufgetreten war, sind anatomische Zusammenhänge der beiden Ductus in der Vaterschen Papille von vielen Forschern eifrig erörtert worden. Dock die Angaben über die Frequeuz der gemeinsamen Mündung von Gallengang und Pankreasgang, gehen eft stark auseinander. Das kommt wohl aus der Verschiedenheit der Untersuchungsmethoden einerseits und aus den Rassenunterschieden der die betr. Autoren umschliessenden Völker andererseits her. Gegenüber der Angabe von Opie von 89% konnten Mann und Giordano bis zu 20%, Cameron und Noble bis zu 74% der Fälle ein gemeinsames Diverticulum nachweisen. Die Möglichkeit der Gefahr von der Entstehung der gemeinsamen Gänge ist nach Mann und Giordano mit nur 3, 5%, nach Cameron und Noble mit 66%, nach H. Mehnen mit 61% anzusetzen. Ich habe nun bei 45 Materialien frischer menechlicher Sektionsleichen einen Schnitt vom Pylorus bis zur Flexura duodeno-jejunalis ausgeführt und zugleich das Pankreas in seiner ganzen Breite mitsamt der Gallenblase und des Choledochus herausgeholt und dasselbe auf einer dicken Pappe befestigt. Sodann habe ich das Duodenum an seiner Aussenseite aufgeschnitten, die Papilla Vateri genau untersucht, von ihr aus die beiden Ductus sondiert und schliesslich dieser Sonde entlang zuerst den Ductus choledochus und dann den Ductus Wirsungianus bis zum kaudalen Ende inzidiert. Vor der Eröffnung derKanallumen habe ich indes die Vatersche Papille mit Tabaksbeutelnaht verschlossen, in den Ductus choledochus Morjodol in der Dosis von 3-4cc eingeführt und auf dem Röntgenbild sowohl das feine Verästelungswerk des Ductus pancreaticus als auch die Wechselbesiehungen zwischen den beiden Ductus sowie die Anwesenheit des Ductus pancreaticus acoesorius untersucht. Die Ergebnisse waren wie folgt: 1) Bei 45 Materialien menechlicher Sektionaleichen habe ich die Wechselbeziehungen beider Ductus an der gemeinschaftlichen Mündungsstelle in 3 Typen einteilend untersucht. 2) Zum I. Typ gehören 42 Falle (93%), in welchen die beiden Ductus eine Papille und ein gemeinsames Diverticulum besitzen. Zieht man davon die 4 Fälle ab, deren gemeinsames Diverticulum mit einer bis kranialen Ende verlaufenden dünnen membranösen Scheidewand versehen ist und infolgedessen kein gemeinsames Lumen mehr aufweist, so schliesst der I. Typ 38 Fälle (84%) ein. Der II. Typ besteht aus nur einem Fall (2%) mit 2 Papillen, welche jede für sich eine selbständige Mündung haben. Der III. Typ besteht aus 2 Fällen (5%), in denen das Duodenum kein eigenes Diverticulum Vateri besitzt und dafür der Ductue pancreaticus unmittelbar in den Ductus choledochus einmündet. In beiden Fällen liegt die Mündungsstelle von der Mündung des Ductus choledochus weit entfernt ab: in dem einen beträgt die Strecke 15mm, in dem anderen 10mm. In den beiden Fällen mündet der Ductus pancreaticus ins den Ductus choledochus in einem annähernd rechten Winkel ein. 3) Die Gefahr, durch Einklemmung der Gallensteine in der Papille gemeinsame Mündung von Gallengang und Pankreasgang entstehen kann, besteht in 34 Fällen unter den sämtlichen 45 Fällen (76%). 4) Der Ductus pancreaticus accessorius ist in 9 Fällen anzutreffen, die 20% der 45 Fälle ausmacht. Er ist aber unter den 14 Fällen, die besonders röntgenologisch untersucht worden sind, in 6 Fällen, also bis zu 43, 5% festgestellt. en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=岡本繁 kn-aut-sei=岡本 kn-aut-mei=繁 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山醫科大學津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=7 article-no= start-page=1405 end-page=1414 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=若菜病に関する実験 第三編 実験的鉤虫犬（経口感染）のテトレン吸入実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=7 article-no= start-page=1398 end-page=1404 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=若菜病に関する実験 第二編 実験的鉤虫犬（経口感染）の肺の所見 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=7 article-no= start-page=1391 end-page=1397 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=若菜病に関する実験 第一編 実験的鉤虫犬（経口感染）の臨床的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部北山内科教室 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=1 article-no= start-page=154 end-page=163 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=人胃の有する造血物質に就ての研究 第3編 胃液中の造血因子に関する検索（SingesのR. R. R及びDuesberg氏反応） en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本嘉之 kn-aut-sei=岡本 kn-aut-mei=嘉之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=1 article-no= start-page=148 end-page=153 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=人胃の有する造血物質に就ての研究 第2編 胃組織中の乳酸菌増殖因子（葉酸）に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本嘉之 kn-aut-sei=岡本 kn-aut-mei=嘉之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=1 article-no= start-page=132 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=人胃の有する造血物質に就ての研究 第1編 胃組織中の所謂Castleの造血物質に就て en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本嘉之 kn-aut-sei=岡本 kn-aut-mei=嘉之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部津田外科教室 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=1 article-no= start-page=28 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=術前後に於ける肝機能の消長並に之に及ぼす早期離床，温泉浴の影響に関する研究 第三編 温泉浴の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本公尹 kn-aut-sei=岡本 kn-aut-mei=公尹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所外科 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=1 article-no= start-page=17 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=術前後に於ける肝機能の消長並に之に及ぼす早期離床，温泉浴の影響に関する研究 第二編 早期離床の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本公尹 kn-aut-sei=岡本 kn-aut-mei=公尹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所外科 END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=1 article-no= start-page=4 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=術前後に於ける肝機能の消長並に之に及ぼす早期離床，温泉浴の影響に関する研究 第一編 二，三外科手術前後に於ける肝機能の消長 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=岡本公尹 kn-aut-sei=岡本 kn-aut-mei=公尹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学温泉研究所外科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2611 end-page=2628 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Hypoplastic Anemia (panmyelopathy); (Mainly depending on our departmental experiences) kn-title=汎骨髓病（再生不良性貧血）について―教室の経験を中心として― en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Japan, hypoplastic anemia has ever been presenting one of the most important problems among today's anemic diseases, it having proved as great frequency as that of pernicious anemia found both in Europe and America; besides, no fit therapeutic method been discovered as yet. Generally speaking, this disease shows a decrease of entire corpuscles, the bleeding tendency becoming prevalent in most cases; yet as to signs in concern to bone marrow, the number of nuclear cell is not fixed, as it has proved 16, 200 at the lowset, while, 263, 000 at the highest. Consequently, it has been classified into 5 types in our department, in view to obstructions of bone marrow. 1. Type of bloodcell-arrest. 2. Type of maturation-arrest. 3. Type of disturbanced regeneration. 4. Mixed type. 5. Panmyelophthisis. When we took record about 23 cases of hypoplastic patients, results were as follows; 1st type 7, 2nd type 2, 3rd type 3, 4th type 8, and 3 cases of 5th type. In all serum iron value proved an increase; in view to intravenous iron tolerance test, the degree of iron disappearance proved a marked delay, while hematopoetic function indicated an extreme decline. In tissue culture of bone marrow invented by our department. it has been recognized that there exists certain factor to inhibit any hyperplasia of parencyma of bone marrow in this anemic serum. As for method in therapy, several have been nominated through in vain, so that more or less effect have been achieved only by our inventions, i.e., imbedding of bone marrow as well as use of substances of polysaccharide extracted from bone marrow. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= en-aut-name=OkanoTakuya en-aut-sei=Okano en-aut-mei=Takuya kn-aut-name=岡野卓也 kn-aut-sei=岡野 kn-aut-mei=卓也 aut-affil-num=2 ORCID= en-aut-name=SaitoTetsuro en-aut-sei=Saito en-aut-mei=Tetsuro kn-aut-name=齊藤哲郎 kn-aut-sei=齊藤 kn-aut-mei=哲郎 aut-affil-num=3 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=木村郁郎 kn-aut-sei=木村 kn-aut-mei=郁郎 aut-affil-num=4 ORCID= en-aut-name=TanakaMotosuke en-aut-sei=Tanaka en-aut-mei=Motosuke kn-aut-name=田中基介 kn-aut-sei=田中 kn-aut-mei=基介 aut-affil-num=5 ORCID= en-aut-name=YamashitaMiyokichi en-aut-sei=Yamashita en-aut-mei=Miyokichi kn-aut-name=山下三代吉 kn-aut-sei=山下 kn-aut-mei=三代吉 aut-affil-num=6 ORCID= en-aut-name=ShindoTsutomu en-aut-sei=Shindo en-aut-mei=Tsutomu kn-aut-name=進藤勉 kn-aut-sei=進藤 kn-aut-mei=勉 aut-affil-num=7 ORCID= en-aut-name=KuninobuMasuhiro en-aut-sei=Kuninobu en-aut-mei=Masuhiro kn-aut-name=国延益弘 kn-aut-sei=国延 kn-aut-mei=益弘 aut-affil-num=8 ORCID= en-aut-name=TominagaHiroshi en-aut-sei=Tominaga en-aut-mei=Hiroshi kn-aut-name=富永弘 kn-aut-sei=富永 kn-aut-mei=弘 aut-affil-num=9 ORCID= en-aut-name=IshidaToyoshige en-aut-sei=Ishida en-aut-mei=Toyoshige kn-aut-name=石田豊重 kn-aut-sei=石田 kn-aut-mei=豊重 aut-affil-num=10 ORCID= en-aut-name=TakedaToshiteru en-aut-sei=Takeda en-aut-mei=Toshiteru kn-aut-name=武田俊輝 kn-aut-sei=武田 kn-aut-mei=俊輝 aut-affil-num=11 ORCID= en-aut-name=NumamotoTetsuro en-aut-sei=Numamoto en-aut-mei=Tetsuro kn-aut-name=沼本徹郎 kn-aut-sei=沼本 kn-aut-mei=徹郎 aut-affil-num=12 ORCID= en-aut-name=KotakemoriYasuo en-aut-sei=Kotakemori en-aut-mei=Yasuo kn-aut-name=小武守靖 kn-aut-sei=小武 kn-aut-mei=守靖 aut-affil-num=13 ORCID= en-aut-name=NakayamaAkio en-aut-sei=Nakayama en-aut-mei=Akio kn-aut-name=中山章壮 kn-aut-sei=中山 kn-aut-mei=章壮 aut-affil-num=14 ORCID= en-aut-name=HoenSachihiko en-aut-sei=Hoen en-aut-mei=Sachihiko kn-aut-name=方円幸彦 kn-aut-sei=方円 kn-aut-mei=幸彦 aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=9 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=10 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=11 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=12 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=13 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=14 en-affil= kn-affil=岡山大学医学部平木内科 affil-num=15 en-affil= kn-affil=岡山大学医学部平木内科 END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=11 article-no= start-page=2289 end-page=2307 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=STATISTICAL OBSERVATION ON 28 CASES OF HYPOP-LASTIC ANEMIA. (PANMYELOPATHIA) kn-title=汎骨髓病症（再生不良性貧血）28例の統計的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We have taken observations on 28 cases of Panmyelopathia, all of which belonged to inpatients of our dept., statistically and clinically; results were as follows:- There were found no definite co-relations either iu age, sex. or by occupation; except 1 case of chronic X-Ray injury; for conscious symptoms, facial paleness was found almost inevitably, while fever, general languor, and palpitation were discovered to succeed it; as for the bleeding, in main it was wont to appear in the form of gingival bleeding, epistaxis, or ecchymosis; for symptoms that were discovered by others, red-cell sedimentation rate was found to be stimulated, in total cases, and such as lengthened bleeding time, anemic cardiac murmurs, together with changes in the eye ground, was recognizable in most cases. Among the blood figure. number of red cells was seen to be about a million or so in majority of cases; while, figures below 1 million was considered to point at serious prognosis. As to hemoglobin content, in most cases, it occupied 20% or so; in respect to hemoglobin index, most of them indicated a hyperchrom, over the entire process, or in partial process. In most cases, the numher of leucocytes proved to be short of 4000, which was also supposed to keep much co-relation with the prognosis. In view to differentiation of lencocytes, a decrease of grauulocytes, an increase of lymphocytes appeared, and in general, in deceased cases, lymphocytosis was clearly observed. Number of blood platelet were apt to decrease to a certain extent. Number of reticulocytes was seen to be small in majority of cases, but it would seem unreasonable to refer to it for the state of prognosis. Heinz' body proved, in serious cases, a value pretty nigh to 1, 000‰, showing a great difference with that, belonging to another sort of anemic diseases, as well as people in healthy condition. No special phase was foundin the myelogramm; in respective disease, various apperances of hematopoetic functions observed. The disease could generally be divided into following 5 types. I. Type of bloodcell-arrest. II. Type of maturation-arrest III. Type of disturbanced regeneration. IV. Mixed type. V. Panmyelophthisis. By dint of Tissue Culture of bone marrow. it has been supposed that there existed certain factor that inhibited growth of parenchyma of bone marrow directly; moreover, the functions of bone marrow have suffered a marked hindrance; Having examined respiration and glycolysis in bone marrow, it was discovered that with type of blodcell-arrest, it has proved normal; with other typs, proved considerablly low value. Its sideroblastogram proved slightly to shift to the right. Generally in most cases, gastric juice showed certain hypoacidity. Among the circulatory system, no unique quality discovered, while the rise in serum iron value was seen, owing to extreme decrease of hematopoetic function. Amongst urine and cerebrospinal fluid, some anemia-causing substance has been detected. As for sugar metabolism, rate for normal and abnormal stood almost the same; while as for the basal metabolism, there was discovered some abnormality. The function test of autonomic nervous system, also showed much abnormality. As to histological view, a high degree atrophy was discovered in hematopoetic tissue, with a marked bleeding tendency. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= en-aut-name=NumamotoTetsuro en-aut-sei=Numamoto en-aut-mei=Tetsuro kn-aut-name=沼本徹郎 kn-aut-sei=沼本 kn-aut-mei=徹郎 aut-affil-num=2 ORCID= en-aut-name=TamuraHajime en-aut-sei=Tamura en-aut-mei=Hajime kn-aut-name=田村甫 kn-aut-sei=田村 kn-aut-mei=甫 aut-affil-num=3 ORCID= en-aut-name=OkanoTakuya en-aut-sei=Okano en-aut-mei=Takuya kn-aut-name=岡野卓也 kn-aut-sei=岡野 kn-aut-mei=卓也 aut-affil-num=4 ORCID= en-aut-name=KitayamaMinoru en-aut-sei=Kitayama en-aut-mei=Minoru kn-aut-name=北山稔 kn-aut-sei=北山 kn-aut-mei=稔 aut-affil-num=5 ORCID= en-aut-name=TakedaKatsumi en-aut-sei=Takeda en-aut-mei=Katsumi kn-aut-name=武田勝美 kn-aut-sei=武田 kn-aut-mei=勝美 aut-affil-num=6 ORCID= en-aut-name=TsushimaMakoto en-aut-sei=Tsushima en-aut-mei=Makoto kn-aut-name=津島允 kn-aut-sei=津島 kn-aut-mei=允 aut-affil-num=7 ORCID= en-aut-name=NakatsukaGinta en-aut-sei=Nakatsuka en-aut-mei=Ginta kn-aut-name=中塚銀太 kn-aut-sei=中塚 kn-aut-mei=銀太 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部平木内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=2 article-no= start-page=59 end-page=98 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Income Distribution and Tax Reforms in Aging Japan kn-title=所得分布と高齢化社会における税制改革 en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper examines the effects of changes in the variance of income distribution on both capital accumulation and social welfare in Japan, the society with an aging population. To analyze the problem, we adopt a simulation approach for an extended life-cycle general equilibrium model of overlapping generations with continuous income distribution. The simulation results indicate that the changes in the variance affect economic variables under a progressive tax scheme but they do not under a proportional tax scheme. The results also show that social welfare greatly increases as the variance shrinks. Therefore, the recent shift in Japan, where the taxation system has tended in effect to become flat, may cause a significant damage to social welfare. en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name=岡本章 kn-aut-sei=岡本 kn-aut-mei=章 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=1 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Heterogeneous Labor Endowments and Tax Reforms in Aging Japan: Progressive Taxes and Intragenerational Redistribution kn-title=労働異質性と高齢化社会における税制改革―累進税制の選択と資産格差への影響― en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper examines the effects of a progressive labor income tax scheme and a progressive consumption tax scheme on capital stock and on intragenerational wealth distribution in Japan, the society with an aging population. To analyze the problem, we adopt a simulation approach for an extended life-cycle general equilibrium model of overlapping generations. As a progressive tax is likely to mitigate the inequality of resource distribution, it is crucial to allow for the existence of heterogeneous labor. This is incorporated by assuming that each cohort has three representative individuals with equal tastes but unequal annual labor endowments, corresponding to three income classes, namely, low, middle, and high income classes. As the simulation results indicate, a progressive labor income tax shrinks the inequality in the distribution of wealth, while a progressive consumption tax furthers slightly. en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name=岡本章 kn-aut-sei=岡本 kn-aut-mei=章 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=9-10 article-no= start-page=887 end-page=899 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histological study of neuronal damage following 18 minutes of global brain ischemia in dogs kn-title=18分間完全全脳虚血犬の脳組織障害に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The neuronal damage of small to medium sized striatal neurons, hippocampal CA1 pyramidal cells and cerebellar Purkinje cells was histologically studied after reperfusion following 18 minutes of global brain ischemia in dogs. Neuronal damage of small to medium sized striatal neurons progressed up to 6 hours after reperfusion, but further damage was not observed from 6 hours to 7 days after reperfusion. Little damage of either the hippocampal CA1 pyramidal cells or cerebellar Purkinje cells was observed 6 hours after reperfusion, but severe delayed damage of those cells was observed from 24 to 48 hours after reperfusion. These results suggest that the delayed onset of neuronal damage of both hippocampal CA1 pyramidal cells and cerebellar Purkinje cells is due to secondary injury factor (s) after reperfusion subsequent to ischemia. The delayed neuronal damage in this model may be prevented or reduced by treatment of secondary injury factor (s). en-copyright= kn-copyright= en-aut-name=OkamotoTakayuki en-aut-sei=Okamoto en-aut-mei=Takayuki kn-aut-name=岡本隆行 kn-aut-sei=岡本 kn-aut-mei=隆行 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部麻酔・蘇生学教室 en-keyword=全脳虚血 kn-keyword=全脳虚血 en-keyword=イヌ kn-keyword=イヌ en-keyword=海馬CA1 kn-keyword=海馬CA1 en-keyword=プルキンエ細胞 kn-keyword=プルキンエ細胞 en-keyword=線条体 kn-keyword=線条体 END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=5-6 article-no= start-page=505 end-page=515 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Test for susceptibility to anticancer drugs by human tumor clonogenic assay and anticancer effects of natural human tumor necrosis factor-α and natural human interferon-α kn-title=Human tumor clonogenic assayを用いた制癌剤感受性試験とnatural human Tumor Necrosis Factorの抗腫瘍効果に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The human tumor clonogenic assay is a test of susceptibility to anticancer drugs which is known to correlate well with clinical effects. In this report, this assay was used to study the antitumor effects of several anticancer drugs and human tumor necrosis factor-α (nHuTNF-α), and the combination effect of nHuTNF-α and natural human interferon-α (nHuIFN-α). Susceptibility to exisiting anticancer drugs was studied in 94 cases involving 92 patients. Colony formation was obtained 50 cases (53.2%). Of these, susceptibility to ADM was found in 15 cases, to MMC in 8 cases and to 5-Fu in 11 cases. When the antitumor effect of nHuTNF-α was studied in 10 cases obtained from patients with malignant tumor, colony inhibition was shown in 9 cases of more than 30% with 100 units and more than 50% with 300 units. A synergistic effect was assessed with a combination of nHuTNF-α and nHuIFN-α against 4 cell lines (KB, Hep-2, KATO-III, PC-9). The results showed a synergistic effect in KB and Hep-2 cell culture system. From these results, nHuTNF-α seemed to be effective anticancer drugs. The synergistic antitumor effect may be expected if the combination of nHuTNF-α and nHuIFN-α was used clinically. en-copyright= kn-copyright= en-aut-name=OkamotoKanji en-aut-sei=Okamoto en-aut-mei=Kanji kn-aut-name=岡本幹司 kn-aut-sei=岡本 kn-aut-mei=幹司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=Human tumor clonogenic assay kn-keyword=Human tumor clonogenic assay en-keyword=抗癌剤感受性試験 kn-keyword=抗癌剤感受性試験 en-keyword=natural human interferon-α kn-keyword=natural human interferon-α en-keyword=natural human tumor necrosis factor-α kn-keyword=natural human tumor necrosis factor-α en-keyword=preclinical early phase II study kn-keyword=preclinical early phase II study END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=3 article-no= start-page=231 end-page=236 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of transverse colon cancer with remarkable extramural invasion to stomach and jejunum kn-title=壁外性に腫瘤を形成し胃・小腸浸潤を示した横行結腸癌の１例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 77-year-old woman was admitted to our hospital due to abdominal pain and body weight loss. A palpable mass the size of an infant's head was tender on palpation and identified as an epigastric lesion. Colonoscopic examination revealed stenosis of the transverse colon, although no intraluminal growth of the tumor was found. The histologic findings of the biopsy material were poorly differentiated and/or undifferentiated cells. Abdominal CT scan showed an irregular-shaped tumor with a diameter of 10cm invading the stomach and jejunum. We performed an operation under a diagnosis of extramurally growing cancer or malignant lymphoma of the colon. Partial resection of the transverse colon was done by distal gastrectomy and partial resection of the jejunum. Histologic examination of the operative specimens revealed moderately differentiated adenocarcinoma of the transverse colon, prominently proliferating into the surrounding tissues. The finding of a long stenotic lesion and extramural compression by colonography are characteristic of this tumor, based on a review of 43 literature reports in Japan. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=濱野亮輔 kn-aut-sei=濱野 kn-aut-mei=亮輔 aut-affil-num=1 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=大塚眞哉 kn-aut-sei=大塚 kn-aut-mei=眞哉 aut-affil-num=2 ORCID= en-aut-name=KimuraYuuji en-aut-sei=Kimura en-aut-mei=Yuuji kn-aut-name=木村裕司 kn-aut-sei=木村 kn-aut-mei=裕司 aut-affil-num=3 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=西江学 kn-aut-sei=西江 kn-aut-mei=学 aut-affil-num=4 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=徳永尚之 kn-aut-sei=徳永 kn-aut-mei=尚之 aut-affil-num=5 ORCID= en-aut-name=MiyasouHideaki en-aut-sei=Miyasou en-aut-mei=Hideaki kn-aut-name=宮宗秀明 kn-aut-sei=宮宗 kn-aut-mei=秀明 aut-affil-num=6 ORCID= en-aut-name=TsunemituYousuke en-aut-sei=Tsunemitu en-aut-mei=Yousuke kn-aut-name=常光洋輔 kn-aut-sei=常光 kn-aut-mei=洋輔 aut-affil-num=7 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=稲垣優 kn-aut-sei=稲垣 kn-aut-mei=優 aut-affil-num=8 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=岩川和秀 kn-aut-sei=岩川 kn-aut-mei=和秀 aut-affil-num=9 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=2 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=3 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=4 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=5 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=6 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=7 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=8 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=9 en-affil= kn-affil=国立病院機構福山医療センター　外科 affil-num=10 en-affil= kn-affil=国立病院機構福山医療センター　外科 en-keyword=大腸癌 (colon cancer) kn-keyword=大腸癌 (colon cancer) en-keyword=壁外性発育 (extraluminal growth) kn-keyword=壁外性発育 (extraluminal growth) END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=4 article-no= start-page=193 end-page=201 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Introduction of Progressive Expenditure Taxation to Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=With a population that is aging faster than any other in the world, Japan faces serious public finance problems, particularly when it comes to tax and social security issues. The structural reforms are urgently needed to accommodate the impending demographic change. We look at the Japanese tax and social security systems through a life−cycle general equilibrium simulation model. We aim to establish guidelines for fiscal reform in Japan’s graying society and use such advanced modeling techniques to permit the calculation of the effects of alternative tax policies on capital accumulation and economic welfare. We also examine the impact of progressive expenditure taxation, coming to the novel conclusion that this form of taxation may hold the key to overcoming the large welfare loss Japan faces as its society ages under the current tax system. Furthermore, we present the concrete measures of implementing progressive expenditure taxation. en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Faculty of Economics, Okayama University END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=2 article-no= start-page=47 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Welfare Analysis of Progressive Expenditure Taxation in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper aims to establish guidelines for public pension reform in an aging Japan, using a numerical simulation approach. The paper examines the effects of demographic change and public pension policies on economic growth and welfare, using a dynamic life-cycle general equilibrium model. It deals with the benchmark case with the current Japanese pension schedule based on the 2004 reform, and the reform cases in which the whole basic pension benefit is financed by a consumption tax and in which the earnings-related pension is abolished. Moreover, it handles the case in which a progressive expenditure (or consumption) tax is introduced. The simulation results show that the level of economic welfare is higher under these reforms than under the current pension schedule. en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name=岡本章 kn-aut-sei=岡本 kn-aut-mei=章 aut-affil-num=1 ORCID= en-aut-name=ShimaToshihiko en-aut-sei=Shima en-aut-mei=Toshihiko kn-aut-name=島俊彦 kn-aut-sei=島 kn-aut-mei=俊彦 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=University of Tokyo en-keyword=Aging population kn-keyword=Aging population en-keyword=Public pension reform kn-keyword=Public pension reform en-keyword=Basic pension kn-keyword=Basic pension en-keyword=Progressive expenditure tax kn-keyword=Progressive expenditure tax en-keyword=Life-cycle general equilibrium simulation model kn-keyword=Life-cycle general equilibrium simulation model END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1-2 article-no= start-page=59 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Alternative methods to evaluate the protective ability of sunscreen against photo-genotoxicity en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Numerous epidemiological investigations show that sunlight is carcinogenic to humans and that the use of sunscreen may be effective in decreasing the risk of skin cancer. The biological activity of a sunscreen is evaluated by its ability to protect human skin from erythema as represented by a Sun Protection Factor (SPF). We propose that the sunscreen's protective effect against sunlight-induced genotoxicity, including mutation, should also be taken into account. In this study we examined the protective ability of sunscreens against natural sunlight and UV-induced genotoxicity in Drosophila somatic cells. We prepared three kinds of sunscreen samples, each with an SPF value of 20, 40 or 60 and compared their protective activities with commercial sunscreens. When a sunscreen of SPF 20, 40 or 60 was pasted on the plastic cover of a petri dish in which Drosophila larvae were exposed to the sun or UV lamps, genotoxicity decreased as the SPF of the sunscreen increased, relative to levels of genotoxicity observed in samples without sunscreen. However, the protective abilities of sunscreens were unexpectedly not so different from each other. To reveal the relationship between the protective activity of sunscreen and the wavelength of light with which larvae were irradiated through the sunscreen, we measured the transmittance of light through the petri dish cover on which the sunscreen was pasted. Effective protection was demonstrated by removing components of light whose wavelengths were below 315 nm. We suggest, that the measurement of anti-genotoxic activity and the determination of the wavelengths of light transmitted through the sunscreen should be an alternative method for evaluating the effectiveness of a sunscreen.

en-copyright= kn-copyright= en-aut-name=ToyoshimaMegumi en-aut-sei=Toyoshima en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HosodaKanako en-aut-sei=Hosoda en-aut-mei=Kanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HanamuraMiho en-aut-sei=Hanamura en-aut-mei=Miho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KobayashiHiroshi en-aut-sei=Kobayashi en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NegishiTomoe en-aut-sei=Negishi en-aut-mei=Tomoe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Shiseido Research Center affil-num=6 en-affil= kn-affil=Okayama University en-keyword=sunscreen kn-keyword=sunscreen en-keyword=sunlight kn-keyword=sunlight en-keyword=UVB kn-keyword=UVB en-keyword=somatic cell mutation kn-keyword=somatic cell mutation en-keyword=genotoxicity kn-keyword=genotoxicity en-keyword=transmittance kn-keyword=transmittance en-keyword=Drosophila melanogaster kn-keyword=Drosophila melanogaster END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=6 article-no= start-page=267 end-page=277 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Pathophysiological functions of CD30+ CD4+ T cells in rheumatoid arthritis. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

High levels of soluble CD30 (sCD30) were detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA), indicating the involvement of CD30+ T cells in the pathogenesis. We investigated the induction of CD30 and its functions in CD4+T cells from patients with established RA (disease duration >_2 years). CD4+ T cells from both the peripheral blood (PB) and synovial tissue (ST) of RA patients expressed surface CD30 when stimulated with anti-CD3 antibody (Ab) and anti-CD28 Ab, but their CD30 induction was slower and weaker compared with PB CD4+ T cells of healthy controls (HC). Immunohistochemical analysis showed that only a small proportion of lymphocytes expressed CD30 in the ST (-1%). RA PB CD4+ T cells, after recovery from 6-day stimulation with anti-CD3 Ab and anti-CD28 Ab, showed in intracellular cytokine staining that CD30+ T cells could produce more interleukin-4 (IL-4) but less interferon-gamma. In the culture of RA PB CD4+ T Cells with anti-CD3 Ab and anti-CD28 Ab, blocking anti-CD30 Ab similarly inhibited the cell proliferation and activation of nuclear factor-kappaB on day 4 in RA and HC, but inhibited the apoptotic cell death on day 6 only in RA. These results indicate that despite high-level expression of sCD30, the anti-inflammatory activity of IL-4-producing CD30+ CD4+ T cells may be limited in the ST due to a poor induction of surface CD30 and a susceptibility to CD30-mediated cell death.

en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamuraMasahiro en-aut-sei=Yamamura en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IwahashiMitsuhiro en-aut-sei=Iwahashi en-aut-mei=Mitsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AitaTetsushi en-aut-sei=Aita en-aut-mei=Tetsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UenoAkiko en-aut-sei=Ueno en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KawashimaMasanori en-aut-sei=Kawashima en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamanaJiro en-aut-sei=Yamana en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KagawaHidetoshi en-aut-sei=Kagawa en-aut-mei=Hidetoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University en-keyword=apoptosis kn-keyword=apoptosis en-keyword=CD4 Tcells kn-keyword=CD4 Tcells en-keyword=CD30 kn-keyword=CD30 en-keyword=interleukin-4(IL=4) kn-keyword=interleukin-4(IL=4) en-keyword=rheumatoid arthritis(RA) kn-keyword=rheumatoid arthritis(RA) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=6 article-no= start-page=363 end-page=371 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Toxin Production by Aeromonas sobria in Natural Environments: River Water vs. Seawater en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Aeromonas are water-borne pathogens. They are halotolerant, which means that they can survive in environments whose salt content corresponds to that of seawater (3.0% NaCl). However, the presence of Aeromonas in seawater is extremely rare compared with that in river water. In this study, we tested the ability of Aeromonas sobria to produce toxins in river water and seawater. First, we cultured A. sobria on skim milk agar plates supplemented with either river water (SARW) or seawater (SASW). The bacteria grew on both plates. A clear zone around the bacteria was generated in SARW. However, such a zone was not observed in SASW, suggesting that proteases were not generated in SASW. Subsequently, we cultured A. sobria in a nutrient broth supplemented with either river water (NRW) or with seawater (NSW), and examined the protease activity of their culture supernatants. The protease activity of the culture supernatant from NSW was extremely low compared to that from NRW. The immunoblotting analysis showed that serine protease (ASP) was not produced by the culture in NSW. By contrast, aerolysin-like hemolysin was produced in all conditions examined in this study. This indicates that the salinity of water is deeply involved in the production of ASP by A. sobria.

en-copyright= kn-copyright= en-aut-name=KhanRasel en-aut-sei=Khan en-aut-mei=Rasel kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiEizo en-aut-sei=Takahashi en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakuraHironori en-aut-sei=Nakura en-aut-mei=Hironori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AnsaruzzamanMohammad en-aut-sei=Ansaruzzaman en-aut-mei=Mohammad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=BanikSukalyani en-aut-sei=Banik en-aut-mei=Sukalyani kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=RamamurthyThandavarayan en-aut-sei=Ramamurthy en-aut-mei=Thandavarayan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Laboratory of Protein Function, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Laboratory of Protein Function, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Laboratory of Protein Function, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Laboratory Sciences Division, ICDDR, B (International Centre for Diarrhoeal Diseases Research, Bangladesh), Centre for Health and Population Research affil-num=5 en-affil= kn-affil=Laboratory of Protein Function, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India affil-num=7 en-affil= kn-affil=Laboratory of Protein Function, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=Aeromonas kn-keyword=Aeromonas en-keyword=water kn-keyword=water en-keyword=toxin kn-keyword=toxin en-keyword=salinity kn-keyword=salinity END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue= article-no= start-page=45 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effect of Thermal Spring Water on Drug Absorption in Special Reference to Aspirin and Indomethacin kn-title=温泉水飲用の薬物吸収におよぼす影響（インドメタシン,アスピリンの場合） en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is thought that a drug reacts differently with media taken internally. The solubility of Aspirin is assured 600μg/ml in 30min. with Misasa spring water, whereas 400μg/ml with plain water. The parallel difference of 200μg/ml follows 10 min. thereafter. Maximum serum concentratin of 200μg/ml is obtained 2 hours after the internal use of Aspirin with Misasa spring water in parallel difference of 20μg/ml with plain water. In the case of Indomethacin intake, maximum serum concentration of 1.5μg/ml is obtained in 2 hours with plain water, whereas maximum serum concentration of 1μg/ml is obtained in the same period with Misasa spring water. However, the difference of 0.25μg/ml in serum concentration between the media internally taken is seen initially and after 4 hours under high concentration of Indomethacin. We, therefore, assume tentatively that the effect of Aspirin and Indomethacin is supposed to be enhanced with Misasa spring water taken internally. en-copyright= kn-copyright= en-aut-name=OkamotoTeruko en-aut-sei=Okamoto en-aut-mei=Teruko kn-aut-name=岡本輝子 kn-aut-sei=岡本 kn-aut-mei=輝子 aut-affil-num=1 ORCID= en-aut-name=HiranoMitsuhiro en-aut-sei=Hirano en-aut-mei=Mitsuhiro kn-aut-name=平尾光宏 kn-aut-sei=平尾 kn-aut-mei=光宏 aut-affil-num=2 ORCID= en-aut-name=FurunoKatsushi en-aut-sei=Furuno en-aut-mei=Katsushi kn-aut-name=古野勝志 kn-aut-sei=古野 kn-aut-mei=勝志 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1-3 article-no= start-page=119 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of ATP on Hematopoietic Functions of Bone Marrow 3. Influences of ATP on Erythropoietic Functions of Rabbit, Normal Human and Hypoplastic Marrow kn-title=Adenosine triphosphate (ATP) の骨髄造血機能に及ぼす影響に関する研究 第3編 骨髄組織培養に於ける赤血球系造血機能に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of observing the influences of ATP on the bone marrow erythropoiesis, a roller tube culture method was used to cultivate bone marrow cell suspensions from normal rabbits, normal persons and patients with hypoplastic anemia. ATP solutions at various concentrations were added directly to the culture media and observations were carried out. As a result, it has been shown that addition of ATP resulted in an increase of erythrocytes, increase of hemoglobin content and increasing percentage of orthochromic erythroblasts. en-copyright= kn-copyright= en-aut-name=OkamotoMichio en-aut-sei=Okamoto en-aut-mei=Michio kn-aut-name=岡本迪男 kn-aut-sei=岡本 kn-aut-mei=迪男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1-3 article-no= start-page=113 end-page=118 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of ATP on Hematopoietic Functions of Bone Marrow 2. Influences of ATP on Thrombopoietic Functions of Guinea Pig, Normal Human and Hypoplastic Marrow kn-title=Adenosine triphosphate (ATP) の骨髄造血機能に及ぼす影響に関する研究 第2編 骨髄組織培養に於ける栓球系造血機能に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to observe the influences of ATP on the bone marrow thrombopoiesis, clinical tissue culture of bone marrow from normal guinea pigs, normal persons and patients with hypoplastic anemia was conducted. ATP solutions at various concentrations were added directly to the culture media and observations were carried out to see effect of ATP on the functions of megakaryocytes of bone marrow. As a result, it has been seen that by adding an optimal amount of ATP the functions of megakaryocytes were accelerated. en-copyright= kn-copyright= en-aut-name=OkamotoMichio en-aut-sei=Okamoto en-aut-mei=Michio kn-aut-name=岡本迪男 kn-aut-sei=岡本 kn-aut-mei=迪男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1-3 article-no= start-page=105 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of ATP on Hematopoietic Functions of Bone Marrow 1. Influences of ATP on Leukopoietic Functions of Rabbit, Normal Human and Hypoplastic Marrow kn-title=Adenosine triphosphate (ATP)の骨髄造血機能に及ぼす影響に関する研究 第1編 骨髄組織培養に於ける白血球系造血機能に及ぼす影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to observe the influences of ATP on the bone marrow leukopoiesis, clinical tissue culture of bone marrow from normal rabbits, normal persons and patients with hypoplastic anemia was conducted. ATP solutions at various concentrations were added directly to the culture media and observations were carried out to see effect of ATP on the functions of neutrophils of bone marrow. As a result, it has been demonstrated that by adding an optimal amount of ATP the ontgrowth, cell density and wandering velosity of neutrophils were increased. en-copyright= kn-copyright= en-aut-name=OkamotoMichio en-aut-sei=Okamoto en-aut-mei=Michio kn-aut-name=岡本迪男 kn-aut-sei=岡本 kn-aut-mei=迪男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科 END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=11-12 article-no= start-page=947 end-page=956 dt-received= dt-revised= dt-accepted= dt-pub-year=1967 dt-pub=19671230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunofluorescent Studies on the Tumor Iuduced by Adenovirus Type 12 3. Sequential Observation on the local Carcinogenesis After Virus Inoculation to Newborn Hamsters kn-title=螢光抗体法によるアデノウィルス12型誘発腫瘍の検索 3. ウィルス接種後,発癌に到る迄の局所変化について en-subtitle= kn-subtitle= en-abstract= kn-abstract=By means of immunofluorescent technic, the author investigated the sequential changes of the viral antigens and tumor antigens in the tissue of newborn hamsters inoculated with adenovirus tyqe 12. 1. Subcutaneous inoculation Viral antigens could not already be found 4-5 hours after virus injection, but tumor antigens diffusely appeared in the injected part at least 24 hours later. In process of time, tumor antigens were gradually localized to the corium and muscle layer. Atypical large cells were recognized in the intermuscular bundles 15 days after inoculation, stained with strong, brilliant fluorescence. Histomorphologically they were identified with tumor cells originated from immature nerve-supporting cells which corresponded to muscle spindles or motor endplates. 2, Intraperitoneal inoculation Viral antigens could not almost be found 4-5 hours after injection, followed by appearance of tumor antigens 12-24 hours later. On the observation of the mesenterium tumor antigens also gradually localized and became more and more strongly stained on the nerve fibers, spindle shaped cells (probably schwann's cells) as well as ganglion cells. In 7-10 days after inoculation, small tumor nodules which showed bright fluorescence were found closely related with nerve fibers. On the other hand, the tumor antigens on the serosa cells became gradually weak and the degeneration of serosa cells was demonstrated after 3-7 days, which resembled cytopathic effect of infected HeLa-cells in vitro. 3. Intracranial inoculation Viral antigens disappeared more rapidly (one hour after virus inoculation) and tumor antigens were gradually located principally in the ependymal layer, meninx, but sometimes in the parenchyma of the brain which related to small blood vessels. Moreover, viral antigens were detected after three hours in the Kupffer cells of the liver and sinusendothelial cells of the spleen. en-copyright= kn-copyright= en-aut-name=OkamotoTsukasa en-aut-sei=Okamoto en-aut-mei=Tsukasa kn-aut-name=岡本司 kn-aut-sei=岡本 kn-aut-mei=司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二病理学教室 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=7-8 article-no= start-page=527 end-page=534 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A report of field survey on acatalasemia and hypocatalasemia in 1972 and 1973 kn-title=昭和47年度および48年度 Acatalasemia, Hypocatalasemia 調査集計 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The authors reported the results of field survey on acatalasemia and hypocatalasemia during the year of 1972 and 1973. Seventeen hypocatalasemias were seen in the test of 7,475 individuals at Oahu Is. of Hawaii, U.S.A. Among them two Englishmen, one Portugese and three Filipinos were included. One new acatalasemia case was reported in 1972. Consequently, the total of reported acatalasemias were 97 cases of 47 families by the end of 1973. en-copyright= kn-copyright= en-aut-name=TanakaTohru en-aut-sei=Tanaka en-aut-mei=Tohru kn-aut-name=田中徹 kn-aut-sei=田中 kn-aut-mei=徹 aut-affil-num=1 ORCID= en-aut-name=TakaharaShigeo en-aut-sei=Takahara en-aut-mei=Shigeo kn-aut-name=高原滋夫 kn-aut-sei=高原 kn-aut-mei=滋夫 aut-affil-num=2 ORCID= en-aut-name=OguraYoshio en-aut-sei=Ogura en-aut-mei=Yoshio kn-aut-name=小倉義郎 kn-aut-sei=小倉 kn-aut-mei=義郎 aut-affil-num=3 ORCID= en-aut-name=MasudaYu en-aut-sei=Masuda en-aut-mei=Yu kn-aut-name=増田游 kn-aut-sei=増田 kn-aut-mei=游 aut-affil-num=4 ORCID= en-aut-name=ArakawaKiyoshi en-aut-sei=Arakawa en-aut-mei=Kiyoshi kn-aut-name=荒川清 kn-aut-sei=荒川 kn-aut-mei=清 aut-affil-num=5 ORCID= en-aut-name=KasaiHideo en-aut-sei=Kasai en-aut-mei=Hideo kn-aut-name=笠井英夫 kn-aut-sei=笠井 kn-aut-mei=英夫 aut-affil-num=6 ORCID= en-aut-name=TaniWataru en-aut-sei=Tani en-aut-mei=Wataru kn-aut-name=谷互 kn-aut-sei=谷 kn-aut-mei=互 aut-affil-num=7 ORCID= en-aut-name=ShibaKanji en-aut-sei=Shiba en-aut-mei=Kanji kn-aut-name=芝侃司 kn-aut-sei=芝 kn-aut-mei=侃司 aut-affil-num=8 ORCID= en-aut-name=KurodaYasuo en-aut-sei=Kuroda en-aut-mei=Yasuo kn-aut-name=黒田泰生 kn-aut-sei=黒田 kn-aut-mei=泰生 aut-affil-num=9 ORCID= en-aut-name=OkamotoKaneko en-aut-sei=Okamoto en-aut-mei=Kaneko kn-aut-name=岡本かね子 kn-aut-sei=岡本 kn-aut-mei=かね子 aut-affil-num=10 ORCID= en-aut-name=OhkuraKoji en-aut-sei=Ohkura en-aut-mei=Koji kn-aut-name=大倉興司 kn-aut-sei=大倉 kn-aut-mei=興司 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科教室 affil-num=9 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科教室 affil-num=10 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科教室 affil-num=11 en-affil= kn-affil=東京医科歯科大学人類遺伝研空室 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=3-4 article-no= start-page=253 end-page=259 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study of the influence of air pollution on a human body by Flow-volume curve kn-title=フローボリウム曲線による大気汚染地区の人体影響調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A comparative study of the influence of air pollution on a human body was made between 416 inhabitants in the air-polluted area and 291 inhabitants in the non-air-polluted area, aged 40 to 69, in Mizushima Industrial Area. The condition of air pollution in Mizushima Districts, except some districts, has changed for the better since September in 1973, so there were found less differences between the study and the control areas in both of the values of SO(2) concentration and NO(x) concentration. Accordingly, the incidence of a respiratory disease by air pollution was considered to have no significant difference in comparison with the control area. But, in the pulmonary function test, the values of V(50)/V(25) and V(25)/V(10), especially, by the flow-volume curve were high significantly in the fifties and the sixties of age of the study area. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= en-aut-name=MeguroTadamichi en-aut-sei=Meguro en-aut-mei=Tadamichi kn-aut-name=目黒忠道 kn-aut-sei=目黒 kn-aut-mei=忠道 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生 affil-num=2 en-affil= kn-affil=岡山大学医学部公衆衛生教室 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=119 end-page=124 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study of pulmonary function of chronic bronchitis in the air-polluted area and the non-air-polluted area kn-title=大気汚染地区と非汚染地区の慢性気管支炎の肺機能―フローボリウム曲線を中心にして― en-subtitle= kn-subtitle= en-abstract= kn-abstract=A survey of a respiratory disease was performed among 1433 inhabitants in the air-polluted area, Mizushima Industrial Area, and 568 inhabitants in the non-air-polluted area. And the following results were obtained. The incidence rate of chronic bronchitis was higher in the air-polluted area. But the results on pulmonary function test by flow volume curve showed abnormality much more in cases of chronic bronchitis in the non-air-polluted area. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= en-aut-name=MeguroTadamichi en-aut-sei=Meguro en-aut-mei=Tadamichi kn-aut-name=目黒忠道 kn-aut-sei=目黒 kn-aut-mei=忠道 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生 affil-num=2 en-affil= kn-affil=岡山大学医学部公衆衛生教室 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=67 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pneumoconiosis caused by "sendo" dust and its environmental factor kn-title=い草染土じん肺とその背景 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A survey of pneumoconiosis caused by "send" dust was performed on the rush-mat workers in Seno-cho and Hayashima-cho of Binan district, Okayama Prefecture. The results obtained were as follows: 1) Out of 199 rush-mat workers in Binan district (of whom, 163 subjects with working career of over 10 years in Seno-cho and 36 subjects with career of over 15 years in Hayashima-cho), 2 cases of P(3), 7 cases of P(1) and 6 cases of P(2) were found. 2) Pneumoconiosis due to "sendo" is clay pneumoconiosis and atypical silicosis caused by inhalation of the dust with free silica in low percentage (about 20%). And this disease shows its gradual development. As is evidenced by these, most of the cases of pneumoconiosis due to "sendo" were found in the workers with working career of over 20 years. 3) It was examined that 48.7% of "sendo" dust contained particles of under 5μ in diameter. And a higher incidence of pneumoconiosis due to "sendo" of fancy-mat workers among rush-mat workers was considered to be caused by indoor labor at the ill-ventilated workshop filled with a great deal of "sendo" dust. 4) Accordingly, as preventive measures against "sendo" dust, there needs the improvement of the environment in the workshop to install a ventilation and so on. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生学 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=59 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Report Ⅰ: A survey on polypropylene fancy-mat workers (in summer) kn-title=ポリプロピレン花莚織従業者についての2, 3の調査 第1報 （夏期における調査） en-subtitle= kn-subtitle= en-abstract= kn-abstract=Since about 1967, a polypropylene pipe that is 1.0mm in diameter has been used for weaving fancy mat in place of a rush. And the fancy-mat workers take extremely long working hours to weave it for the pursuit of profits. So, to clarify the relationship between the conditions of working and of their health, a survey was made on 118 workers (of whom, 52 males and 66 females) in 49 households in Seno-cho, Okayama Prefecture, in 1970. The results obtained were as follows: 1) As for the environment in the workshop, a noise level of weaving machines reached 80 phone. This value appeared to show the influence on the physical function of workers. 2) Admitted was want of sleeping hours among most of the workers because of irregular working hours, that is, over ten-hour labor a day (this contained 32.4% of the workers) and a working system of day-and-night shift. 3) Most of subjective fatigue complaints were the cases of chronic fatigue. The values of Donaggio's test of urine were high in 32.7% of the workers. 4) It was found mostly in the subjects of night-working type that values of Flicker descrimination varied more than 10% upward and found in the sujects of early-morning-working type that varied more than 10% downward. 5) As for the conditions of nutrition intake, it appeared that the side food was preferred to the staple food. This tendency is similar to an urban-type, though Seno-cho is located in a rural district. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生学 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=51 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Report Ⅱ: A survey on polypropylene fancy-mat workers (in winter) kn-title=ポリプロピレン花莚織従業者についての2, 3の調査 第2報 （冬期における調査） en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Report Ⅰ, the survey performed on the polypropylene fancy-mat workers in Seno-cho in summer was reported. And the following survey in winter was made on the same subjects on January in 1971. The results obtained were as follows: 1) It was found that 57.6% of the subjects worked for over ten hours a day, and this percentage was higher than in summer. 2) The number of subjective fatigue complaints offered by the workers was smaller in winter. 3) The number of the workers with high values in Donaggio's test of urine was increased in winter. 4) The incidence of low specific gravity of whole blood was higher because of longer working hours in winter. 5) Most of the cases of anemia were found in female workers (aged 28 to 52). These were iron deficiency hypochrome anemia. In these cases, it was observed that after recovery, the hemoglobin content of erythrocytes increased, while that there was no change in the number of erythrocytes. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生学 END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the counterplan for treatment of foul water which oozed out from a dumping ground kn-title=ごみの埋立処理場からの浸出水の処理対策 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author reported generally on the tretment of foul water which oozed out from Makomodani (the valley of Makomo) of the dumping ground in Kurashiki City, Okayama Prefecture. And it is concluded that the most efficient counterplan for foul water pollution is to restrict laying and heaping up the garbage and to drain away the natural water of rain fall by its own passageway made for the rain, letting it not to stream in this Makomodani dumping ground. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生 END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue=7-8 article-no= start-page=863 end-page=868 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=197808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bacteriuria in the community by testape kn-title=試験紙法による集団の細菌尿のスクリーニング成績について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the course of the screening examination of the adult diseases, 4959 inhabitants (both sex with age from 20 to 89 years) of communities in the south of Okayama Prefecture were examined bacteriuria with the nitrite testape (N-multisticks, Ames Co.) without cleaning pudenda from April to December, 1977, and the following results were obtained. 1) The rate of bacteriuria was 1.4% of the examinee, but the rate of bacteriuria of female (1.6% ) was 3.2 times higher than that of male (0.5% ). The rate by age of bacteriuria of male had single peak in his fifties, but that of female had bottom in her thirties, and after this age the rate rose with increasing age. 2) The cystitis of the urinary bladder or the kidney disease were the commonest disease among the past history of the cases, especially in female, with bacteriuria. About 1/4 of the cases with bacteriuria had complaints, and the pollakisuria was the commonest complaints (23.5% ). 3) The cases of bacteriuria complicated with albuminuria or occult blood were superior to that non-complicated in number, and the cases of glykosuria had bacteriuria to a high rate. 4) In 59.5% of the positive cases of the N-multisticks pyuria was observed microscopically in urinary sediments. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=角南重夫 kn-aut-sei=角南 kn-aut-mei=重夫 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学 affil-num=2 en-affil= kn-affil=川崎医科大学 END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue=5-6 article-no= start-page=599 end-page=604 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Frequency of the occult blood in the urine in the community kn-title=集団における尿潜血反応について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the course of the screening examination of the adult diseases, 2692 inhabitants of the community were examined the occult blood in the urine with N-multisticks (Ames Co.) from April to October, 1977, and the following results were obtained. 1) The positive rate of the occult blood in the urine was 16.3% of the examinee, but the rate of female (17.7%) was higher than that of male (12.0%), and the positive rate of the occult blood in the urine became higher with increase in age. 2) Following the cystitis of the urinary bladder the kidney disease was the most prevalent disease among the past history of the urinary tract diseases, and the pollakisuria was the commonest complaints. 3) In the positive cases of the occult blood in the urine, 93.4% of which was protein negative or questionable positive in the urine, but 6.6% of which was protein positive, and this group must have a precise examination. 4) In 61.8% of the positive cases of the occult blood in the urine, the hematuria was observed microscopically in the urinary sediments, and in 1.6% of the positive cases of the occult blood in the urine many cylinders were observed. From the above results, we concluded that it was necessary to add the occult blood examination to the urinary screening examination of the adult diseases. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=1 ORCID= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=角南重夫 kn-aut-sei=角南 kn-aut-mei=重夫 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生 affil-num=2 en-affil= kn-affil=川崎医科大学公衆衛生 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=9-10 article-no= start-page=1285 end-page=1293 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19771030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Charactor of the Old Myocardial Infarctions found in the Mass Examinations in the Community kn-title=集団検診で発見する地域における陳旧性心筋硬塞の特性 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Some cases, living a social life in the community, with the old myocardial infarctions found in the mass examinations concerning cardio-vascular diseases (performed by Department of Public Health, Kawasaki Medical School) were analysed for the purpose of finding the factors which regulate incidences and prognoses of the myocardial infarction, and the following results were obtained. 1) The average finding rate of the myocardial infarctions in 8 years was 0.37 % of the examinees. 2) The must conditions for being alive after myocardial infarctions, got from the studies of the 28 cases fond in 1975, were the following. (1) Most of them were attacked in their 50's or 60's. (2) Most of them had serum-cholesterol with normal level. (3) Two thirds of them were engaged in light or hard work. (4) Many of them had proteinuria. (5) They had almost no relation with glycosuria or obesity which had intimate relation with coronary insufficiency. en-copyright= kn-copyright= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=角南重夫 kn-aut-sei=角南 kn-aut-mei=重夫 aut-affil-num=1 ORCID= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=2 ORCID= en-aut-name=WakimotoKazumasa en-aut-sei=Wakimoto en-aut-mei=Kazumasa kn-aut-name=脇本和昌 kn-aut-sei=脇本 kn-aut-mei=和昌 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生 affil-num=2 en-affil= kn-affil=川崎医科大学公衆衛生 affil-num=3 en-affil= kn-affil=岡山大学教養部 en-keyword=岡山医学会 kn-keyword=岡山医学会 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=1-2 article-no= start-page=115 end-page=119 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on the differences of values of examinees in mass examination of circulatory disease between the two continued years kn-title=循環器集団検診の継続受診例における測定値の変動について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Statistical analyses of the differences of values of examinees, 8333 residents, in mass examination of circulatory disease between the two continued years were carried out and the following results were obtained. 1) The positive rates of proteinuria changed remarkably between the two years, but those of glucosuria did little or nothing, and were rather constant. 2) As 44.1 % of the cases who discontinued antihypertensive therapy had blood pressure under the borderline, so it was not always able to say, we thought that the therapy should not be discontinued. 3) The code number 4-6 of electrocardiography, which was not classified in Minesota code, seemed to be an important finding for the health control. en-copyright= kn-copyright= en-aut-name=NakamuraFumio en-aut-sei=Nakamura en-aut-mei=Fumio kn-aut-name=中村文雄 kn-aut-sei=中村 kn-aut-mei=文雄 aut-affil-num=1 ORCID= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=2 ORCID= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=角南重夫 kn-aut-sei=角南 kn-aut-mei=重夫 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生 affil-num=2 en-affil= kn-affil=川崎医科大学公衆衛生 affil-num=3 en-affil= kn-affil=川崎医科大学公衆衛生 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=1-2 article-no= start-page=109 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Geographical study on the mortality from diabetes mellitus: Comparison with body weights of pupils kn-title=糖尿病死亡の地理的観察 学童,生徒の体重との関係について en-subtitle= kn-subtitle= en-abstract= kn-abstract=To know the distribution of the mortality from diabetes mellitus in Japan and the factors concerned of it, the age-adjusted death rates of diabetes mellitus in each prefecture were calculated by indirect method in the triennial periods of 1969-71, and correlations between the death rates and the average body weights of pupils in each prefecture were studied. Significant correlations between the age-adjusted death rates in 1969-71 and those in 1963-67, 1958-62, and 1953-57 were recognized, and significant correlations were also recognized between the age-adjusted death rates of males and those of females, so prefecture-accumulations of the death rates were recognized. Significant correlations of the average body weights of pupils between 17 years on one hand and 12, and 8 years on the other in 1968 and 1959 were recognized, and constancies of the body weights by prefecture in terms of sex and time were seen. As the correlations between the age-adjusted death rates of diabetes mellitus in 1969-71 and the average body weights of pupils in 1968 and 1959 were significant, the prefecture-accumulations of the death rates of diabetes mellitus seemed to have ralations with the body weights of pupils, and the nutrition of the community. en-copyright= kn-copyright= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=角南重夫 kn-aut-sei=角南 kn-aut-mei=重夫 aut-affil-num=1 ORCID= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=2 ORCID= en-aut-name=YasunagaKayoko en-aut-sei=Yasunaga en-aut-mei=Kayoko kn-aut-name=安永加代子 kn-aut-sei=安永 kn-aut-mei=加代子 aut-affil-num=3 ORCID= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=緒方正名 kn-aut-sei=緒方 kn-aut-mei=正名 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生学教室 affil-num=2 en-affil= kn-affil=川崎医科大学公衆衛生学教室 affil-num=3 en-affil= kn-affil=川崎医科大学公衆衛生学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=1-2 article-no= start-page=51 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study by literatures on the changes in the mortality from diabetes mellitus kn-title=わが国の糖尿病死亡の推移に関する文献的考察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of studying the recent changes in the mortality from diabetes mellitus the crude death rates and the sex-age-specific death rates from diabetes mellitus obtained from Vital Statistics in Japan and the prevalences of diabetes mellitus obtained from Patients Investigation in Japan were analysed. The age-adjusted death rates were calculated from 1950 to 1974 by means of direct method on the basis of sex-specific population in Japan in 1935. 1) The crude death rates and the age-adjusted death rates from diabetes mellitus showed some increases by years, and those death rates of females were superiorr to those of males. 2) The death rates from diabetes mellitus of young people (15-29 years of age) had tendencies to decrease by years, on the contrary those of old people had tendencies to increase by years. The age-specific death rates of females were superior to those of males till the age of 34, but after the age of 35 the death rates of males were superior to those of females. 3) The average sex-age-specific death rates in 1950-54 had a step at the age of 20-29 years, and this disappeared almost in 1970-74. 4) The prevalences of diabetes mellitus from 1965 to 1973 showed increases at the age of 25-64 years, but those increases were not recognized at the age of 20-24 years. The prevalences of diabetes mellitus of males were superior to those of females. The death rate-prevalence ratios of diabetes mellitus showed some decreases at the age of 25-64 years, but those decreases were not recognized at the age of 20-24 years. en-copyright= kn-copyright= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=角南重夫 kn-aut-sei=角南 kn-aut-mei=重夫 aut-affil-num=1 ORCID= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=岡本正 kn-aut-sei=岡本 kn-aut-mei=正 aut-affil-num=2 ORCID= en-aut-name=YasunagaKayoko en-aut-sei=Yasunaga en-aut-mei=Kayoko kn-aut-name=安永加代子 kn-aut-sei=安永 kn-aut-mei=加代子 aut-affil-num=3 ORCID= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=緒方正名 kn-aut-sei=緒方 kn-aut-mei=正名 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=川崎医科大学公衆衛生学教室 affil-num=2 en-affil= kn-affil=川崎医科大学公衆衛生学教室 affil-num=3 en-affil= kn-affil=川崎医科大学公衆衛生学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=1-2 article-no= start-page=115 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of multiple hemangioma developing in the oral cavity and somatically kn-title=口腔領域および全身に多発した血管腫の1例 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hemangioma is a benign tumor composed of vascular tissue which occurs in various parts of the body. In the oral area, it occurs preferentially in soft tissues such as the tongue, lips and buccal mucosa, and in rare cases it is said to develop even in the mandible. However, most cases are solitary and the development of multiple hemangioma all over the body is rare. We report a case of a girl aged 3 years and 5 months with multiple hemangioma in the oral cavity and all over the body. Treatment consisted of injection of sclerosing agents (Sodium Morrhuate), packing, and cryosurgery. The postoperative course was favorable with some reduction in the size of the tumors. en-copyright= kn-copyright= en-aut-name=NagahataShunichiro en-aut-sei=Nagahata en-aut-mei=Shunichiro kn-aut-name=長畠駿一郎 kn-aut-sei=長畠 kn-aut-mei=駿一郎 aut-affil-num=1 ORCID= en-aut-name=OkamotoYoshimitsu en-aut-sei=Okamoto en-aut-mei=Yoshimitsu kn-aut-name=岡本全允 kn-aut-sei=岡本 kn-aut-mei=全允 aut-affil-num=2 ORCID= en-aut-name=KobayashiSeishi en-aut-sei=Kobayashi en-aut-mei=Seishi kn-aut-name=小林清司 kn-aut-sei=小林 kn-aut-mei=清司 aut-affil-num=3 ORCID= en-aut-name=MatsumuraKazuyoshi en-aut-sei=Matsumura en-aut-mei=Kazuyoshi kn-aut-name=松村和良 kn-aut-sei=松村 kn-aut-mei=和良 aut-affil-num=4 ORCID= en-aut-name=KochiHiroyoshi en-aut-sei=Kochi en-aut-mei=Hiroyoshi kn-aut-name=高知宏喜 kn-aut-sei=高知 kn-aut-mei=宏喜 aut-affil-num=5 ORCID= en-aut-name=MonzenMoshiho en-aut-sei=Monzen en-aut-mei=Moshiho kn-aut-name=門前モシホ kn-aut-sei=門前 kn-aut-mei=モシホ aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部口腔外科学教室 en-keyword=口腔内軟組織 kn-keyword=口腔内軟組織 en-keyword=多発性血管腫 kn-keyword=多発性血管腫 END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=1-2 article-no= start-page=47 end-page=76 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study on vascularization of oral mucosal graft after transplantation kn-title=口腔粘膜への粘膜移植後の血管新生に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Damage inflicted on the oral mucosa may result in the development of an unfavorable appearance, functional disturbances, or growth retardation in the buccal-oral cavity region. In an attempt to minimize such disturbances, transplantation of the free oral mucosa was investigated. Changes in the vascular picture were studied by the intravascular injection of chloropercha. Three-dimensional and morphological observations of blood vessels were supported by macroscopical and pathohistological studies. The animals used were 60 adult dogs weighing about 4-8 kg raised in similar conditions. The left and right buccal mucosal flaps and the left and right maxillary third incisors served as the material. Intravenous anesthesia was used. In Exp. 1: a 1.0 x 1.0 cm piece was taken from the left buccal mucosa. A mucosal graft of the same size was obtained from the right buccal mucosa (used for the free buccal mucosa transplantation). In Exp. 2: the right buccal mucosa from which the mucosal flap had been taken was left as an open wound. In Exp. 3: a gingival section (1.0 x 1.0 cm) was taken from both sides of the maxillary gingiva at the level of the third maxillary incisors. A free buccal gingival graft was prepared from the left side and transplanted to the open wound on the right. The free buccal gingival graft from the right side was transplanted to the open wound on the left. 1) In the free buccal mucosal transplantation to the buccal mucosa, slight intrusion of blood vessels into the transplant was obvious 2 days after transplantation. By the fifth day many blood vessels had developed, by the sixth day these blood vessels formed a loop in the epithelial region, by the fourteenth day the arrangement of blood vessels had become well arrayed, and by the twentieth day blood vessels gave the same appearance as vessels in the transplantation bed. 2) Transplantation of the free mucosa on to the buccal mucosa of the opposite side gives better healing than leaving the damaged buccal mucosa as an open wound. 3) With transplantation of free gingiva to the gingiva of tooth neck, blood vessels had partially advanced into the transplant by the fifth post-operative day. By the tenth day, loop formation of vessels on the gingival epithelium together with gingival adhesion were well arranged. By the fortyfifth day, blood vessels in the transplant presented a similar picture to the normal. 4) Gingival transplantation to gingiva of the tooth neck gave better healing than buccal mucosal transplantation. Moreover, the appearance after operation was more satisfying. 5) The pathohistological findings for this vascular picture agreed in general with the macroscopic appearance. en-copyright= kn-copyright= en-aut-name=OkamotoYoshimitsu en-aut-sei=Okamoto en-aut-mei=Yoshimitsu kn-aut-name=岡本全允 kn-aut-sei=岡本 kn-aut-mei=全允 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部口腔外科学教室 en-keyword=頬粘膜移植 kn-keyword=頬粘膜移植 en-keyword=歯肉移植 kn-keyword=歯肉移植 en-keyword=粘膜移植 kn-keyword=粘膜移植 en-keyword=口腔粘膜 kn-keyword=口腔粘膜 en-keyword=血管新生 kn-keyword=血管新生 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=シンバスタチンによるヒト歯髄幹細胞の象牙芽細胞分化促進 kn-title=Simvastatin induces the odontogenic differentiation of human dental pulp stem cells (DPSCs) in vitro and in vivo en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoYosuke en-aut-sei=Okamoto en-aut-mei=Yosuke kn-aut-name=岡本洋介 kn-aut-sei=岡本 kn-aut-mei=洋介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=1-2 article-no= start-page=107 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Duplicate foreign bodies in the airway and gastrointestinal tract: Report of a case kn-title=気道・食道に分離した重複異物症例 ―教室異物統計と文献的考察― en-subtitle= kn-subtitle= en-abstract= kn-abstract=A case of having two or more foreign bodies simultaneously in the airway and gastrointestinal tract is rare. The authors reported a case of two foreign bodies. A 54-year-old man who carelessly swallowed thumbtacks visited our clinic. An X-ray examination revealed thumbstack in the right bronchus and another in the stomach. The former was removed with a ventilation bronchoscope, and the latter was excreted spontaneously 2 days later. The authors have experienced 84 cases of esophageal foreign bodies and 47 cases of tracheobroncheal ones in the last 10 years. Cases of foreign bodies in both locations showed a higher frequency in males, and the majority of the cases were of children 3 years old or less. Coins were the most common esophageal foreign body, and peanuts were most common tracheobroncheal foreign body.The most frequent location of the foreign bodies was the cervical constriction in cases of esophageal foreign bodies, being twice as frequent as the right bronchus. Two cases of multiple foreign bodies have been treated in our clinic, and both of them were of 2 coins in the upper esophagus. en-copyright= kn-copyright= en-aut-name=SuehiroMichio en-aut-sei=Suehiro en-aut-mei=Michio kn-aut-name=末広倫雄 kn-aut-sei=末広 kn-aut-mei=倫雄 aut-affil-num=1 ORCID= en-aut-name=UedaSetsuo en-aut-sei=Ueda en-aut-mei=Setsuo kn-aut-name=上田節夫 kn-aut-sei=上田 kn-aut-mei=節夫 aut-affil-num=2 ORCID= en-aut-name=IshiharaMotomasa en-aut-sei=Ishihara en-aut-mei=Motomasa kn-aut-name=石原基正 kn-aut-sei=石原 kn-aut-mei=基正 aut-affil-num=3 ORCID= en-aut-name=TomotsuTakao en-aut-sei=Tomotsu en-aut-mei=Takao kn-aut-name=鞆津尚夫 kn-aut-sei=鞆津 kn-aut-mei=尚夫 aut-affil-num=4 ORCID= en-aut-name=OkamotoHiroshi en-aut-sei=Okamoto en-aut-mei=Hiroshi kn-aut-name=岡本宏司 kn-aut-sei=岡本 kn-aut-mei=宏司 aut-affil-num=5 ORCID= en-aut-name=TasakaShuji en-aut-sei=Tasaka en-aut-mei=Shuji kn-aut-name=田坂周治 kn-aut-sei=田坂 kn-aut-mei=周治 aut-affil-num=6 ORCID= en-aut-name=TamuraShintaro en-aut-sei=Tamura en-aut-mei=Shintaro kn-aut-name=田村慎一郎 kn-aut-sei=田村 kn-aut-mei=慎一郎 aut-affil-num=7 ORCID= en-aut-name=NanbaMasayuki en-aut-sei=Nanba en-aut-mei=Masayuki kn-aut-name=難波正行 kn-aut-sei=難波 kn-aut-mei=正行 aut-affil-num=8 ORCID= en-aut-name=MasudaYu en-aut-sei=Masuda en-aut-mei=Yu kn-aut-name=増田游 kn-aut-sei=増田 kn-aut-mei=游 aut-affil-num=9 ORCID= en-aut-name=OguraYoshio en-aut-sei=Ogura en-aut-mei=Yoshio kn-aut-name=小倉義郎 kn-aut-sei=小倉 kn-aut-mei=義郎 aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=2 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=3 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=4 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=5 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=6 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=7 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=8 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=9 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 affil-num=10 en-affil= kn-affil=岡山大学耳鼻咽喉科学教室 en-keyword=気道 kn-keyword=気道 en-keyword=食道 kn-keyword=食道 en-keyword=重複異物 kn-keyword=重複異物 en-keyword=異物統計 kn-keyword=異物統計 END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=1-2 article-no= start-page=21 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Laser Welding of Slices of Magnetic Circuit en-subtitle= kn-subtitle= en-abstract= kn-abstract=In electric power industry, there is a problem of achieving stable joint in different components using high productive and efficient technologies. One type of these components is packages of slices for magnetic circuit of electric motors, transformers etc., which need reliable means for their fixing. Laser welding is proposed to solve this problem as an alternative for existing technologies. The development of the laser welding process is presented based on process simulation, study of heat history and comparison with experimental results. Laser beam additional scanning technique is proposed to improve the quality and efficiency of the joining operation. en-copyright= kn-copyright= en-aut-name=S.kovalenkoVolodymyr en-aut-sei=S.kovalenko en-aut-mei=Volodymyr kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UnoYoshiyuki en-aut-sei=Uno en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AnyakinM. en-aut-sei=Anyakin en-aut-mei=M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=LutayA. en-aut-sei=Lutay en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShubulKhaled Al. en-aut-sei=Shubul en-aut-mei=Khaled Al. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Mechanical Engineering (Now at Laser Technology Research Institute, National Technical affil-num=2 en-affil= kn-affil=Department of Mechanical Engineering affil-num=3 en-affil= kn-affil=Department of Mechanical Engineering affil-num=4 en-affil= kn-affil=Laser Technology Research Institute, National Technical University of Ukraine affil-num=5 en-affil= kn-affil=Laser Technology Research Institute, National Technical University of Ukraine affil-num=6 en-affil= kn-affil=Laser Technology Research Institute, National Technical University of Ukraine END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=2 article-no= start-page=99 end-page=103 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=変形性膝関節炎患者膝関節液中の細胞外マトリックス成分と可溶性VCAM-1 kn-title=Extracellular matrix components and soluble VCAM-1 in synovial fluid with osteoarthritis of the knee en-subtitle= kn-subtitle= en-abstract=変形性膝関節炎(OA)患者は,高齢化社会の到来とともに今後ますます増加するものと考えられる｡OAの発症メカニズムについては,関節軟骨の破壊･修復やパンヌス形成に関わる多くの関連因子(サイトカイン,マトリックス分解酵素,分解酵素抑制因子,プロテオグリカン,活性酸素,細胞接着因子など)について,多面的に研究が進んでいる｡しかし,膝関節の炎症初期の病態のメカニズムについては,なお詳細に解明されておらず,関節炎初期の炎症指標の検索が今後さらに必要と考えられる｡本研究で私たちは, OA患者膝関節液中の細胞外マトリックス構成成分であるコラーゲン,へパラン硫酸プロテオグリカン,ウロン酸および炎症の最も初期に血管内皮細胞に出現するVCAM-1等の可溶化成分濃度を測定した｡患者膝関節液(SF)中の可溶性コラーゲン量と可溶性VCAM-1(sVCAM-1)量とは有意な正の相関関係が(ρ=0.652)観察された｡しかし,ヘパラン硫酸プロテオグリカン(HSPG)と可溶性コラーゲン(sCOLL)値間には有意な相関関係は確認されなかった｡また,一般に炎症の指標として用いられるCRP値とも比戟検討したが,CRP値と他の測定項目値とは一定の相関関係は存在しなかった。以上の結果より,OA患者のSF中の炎症マーカ-として,急性炎症時には従来の炎症指標蛋白質であるCRP値が有力であるというSipe JDの報告から推測するとsCOLLとsVCAM-1はCRP値と一定の相関を示さないことより,CRPの動態とは異なった炎症指標としての有用性が考えられる｡しかし,HSPGはエンドサイトシスにより速やかに代謝されるためSF中への解離が少なく,炎症指標としての可能性は低いと考えられる｡ kn-abstract=It is generally accepted that the number of patients with osteoarthritis (OA) of the knee must increase in the future because of the increase of the aged. The pathogenic mechanisms of OA haven't been elucidated yet, but it is supposed that mediate pannus may cause the factors for irreversible cartilage damage in the inflammatory process. Therefore it is very important to find and predict OA at the early stage. Now there were many indices to determine joint damage with OA, for example, cytokines including IL, TNF, TGF, matrix metalloproteinase (MMPs), tissue inhibitor of metalloproteinase (TIMPs), proteoglycan (PG), hyaluronate (HA), super oxide, adhesion molecules including, ICAM-1, VCAM-1 and PECAM. In this study, we measured that the soluble VCAM-1 (sVCAM-1), soluble collagen (sCOLL), heparansulfate proteoglycan (HSPG), uronic acis and CRP in synovial fluids (SF) with OA. A positive correlation between the level of sVCAM-1 and sCOLL (ρ = 0.652) was noted. However there was no factor showing a correlation with CRP. It was suggested that the levels of sVCAM-1 and sCOLL in the synovia fluid were active inflammation indices of knee damage, as the different aspects from CRP. The level of HSPG also showed a unique trend because HSPG on the cell surface was quickly digested endocytosis, so that it was not suitable for the inflammatory index in synovial fluid with OA. en-copyright= kn-copyright= en-aut-name=TohgeHiroko en-aut-sei=Tohge en-aut-mei=Hiroko kn-aut-name=唐下博子 kn-aut-sei=唐下 kn-aut-mei=博子 aut-affil-num=1 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=一村光子 kn-aut-sei=一村 kn-aut-mei=光子 aut-affil-num=2 ORCID= en-aut-name=SakiyamaJunko en-aut-sei=Sakiyama en-aut-mei=Junko kn-aut-name=崎山順子 kn-aut-sei=崎山 kn-aut-mei=順子 aut-affil-num=3 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=岡本基 kn-aut-sei=岡本 kn-aut-mei=基 aut-affil-num=4 ORCID= en-aut-name=NakataYasunari en-aut-sei=Nakata en-aut-mei=Yasunari kn-aut-name=中田安成 kn-aut-sei=中田 kn-aut-mei=安成 aut-affil-num=5 ORCID= en-aut-name=EndoHiroshi en-aut-sei=Endo en-aut-mei=Hiroshi kn-aut-name=遠藤浩 kn-aut-sei=遠藤 kn-aut-mei=浩 aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=5 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=6 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 en-keyword=変形性膝関節炎 (Osteoarthritis) kn-keyword=変形性膝関節炎 (Osteoarthritis) en-keyword=細胞外マトリックス (Extracellular matrix) kn-keyword=細胞外マトリックス (Extracellular matrix) en-keyword=可溶性VCAM-1 (Soluble VCAM-1) kn-keyword=可溶性VCAM-1 (Soluble VCAM-1) en-keyword=可溶性コラーゲン (Soluble Collagen) kn-keyword=可溶性コラーゲン (Soluble Collagen) en-keyword=可溶性ヘパラン硫酸プロテオグリカン (Soluble HSPG) kn-keyword=可溶性ヘパラン硫酸プロテオグリカン (Soluble HSPG) END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=31 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Correlative study of hippocampal atrophy assessed by MRI and clinical features in temporal lobe epilepsy. kn-title=側頭葉てんかんの海馬萎縮と臨床像の検討 ―MRIを用いた海馬萎縮の簡易評価― en-subtitle= kn-subtitle= en-abstract=We studied hippocampal atrophy in 39 patients with temporal lobe epilepsy using MRI. The ratio (a) of the width of the hippocampus on the atrophic side to that on the contralateral side was measured in coronal sections of the short SE in MRI. According to this ratio, the patients were divided into three groups : 11 with hippocampal atrophy (a<0.8), 13 with borderline atrophy (0.8≦a≦0.9), and 15 with no hippocampal atrophy (a≧0.8). In the patients of the group with hippocampal atrophy, the clinical history of epilepsy tended to be long, and the site of hippocampal atrophy was consistent with that of interictal spike foci on the electroencephalogram in 9 out of 11 patients. However, there was no difference between the three groups, with regard to age at onset, age when MRI was conducted, frequency of seizures, generalized seizures, the types and doses of antiepileptic drugs used, history of neonatal asphyxia, intelligence and epilpetic psychosis. These results suggest that hippocampal atrophy in temporal lobe epilepsy may be related to repetition of epileptic dischargges in a localized part of the brain. kn-abstract=側頭葉てんかん患者39例の海馬萎縮をMRIを用いて評価し,臨床像との関連を検討した｡MRIの冠状断short SE像で海馬の幅を計測し,萎縮側海馬の村側海馬に対する比(a)を求め,海馬萎縮(+)群;a<0.8,11例,境界群;0.8≦a<0.9,13例,海馬萎縮(-)群;a≧0.9,15例の3群に分けた｡海馬萎縮(+)群で罹病期間が長い傾向があった｡また,発作間歇期脳波の焦点側は海馬委縮(+)群の11例中9例で萎縮側と一致した。しかし,発病年齢,MRI撮影時年齢,発作頻度,全般化発作の有無,抗てんかん薬総服用量,知能障害,精神症状,生下時仮死の有無については3群間で差が認められなかった｡この結果から,側頭葉てんかんにおける海馬萎縮は,生下時や全身けいれん発作時の低酸素状態によるものではなく,脳局所の反復するてんかん性発射と関連する可能性が示唆され,海馬萎縮の機序を考えるうえで興味深く思われた。 en-copyright= kn-copyright= en-aut-name=SatoKeiko en-aut-sei=Sato en-aut-mei=Keiko kn-aut-name=佐藤圭子 kn-aut-sei=佐藤 kn-aut-mei=圭子 aut-affil-num=1 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=岡本基 kn-aut-sei=岡本 kn-aut-mei=基 aut-affil-num=2 ORCID= en-aut-name=JojaIkuo en-aut-sei=Joja en-aut-mei=Ikuo kn-aut-name=上着郁夫 kn-aut-sei=上着 kn-aut-mei=郁夫 aut-affil-num=3 ORCID= en-aut-name=NakatsuTakeshi en-aut-sei=Nakatsu en-aut-mei=Takeshi kn-aut-name=中津武志 kn-aut-sei=中津 kn-aut-mei=武志 aut-affil-num=4 ORCID= en-aut-name=MorimotoKiyoshi en-aut-sei=Morimoto en-aut-mei=Kiyoshi kn-aut-name=森本清 kn-aut-sei=森本 kn-aut-mei=清 aut-affil-num=5 ORCID= en-aut-name=HayabaraToshiyuki en-aut-sei=Hayabara en-aut-mei=Toshiyuki kn-aut-name=早原敏之 kn-aut-sei=早原 kn-aut-mei=敏之 aut-affil-num=6 ORCID= en-aut-name=KurodaShigetoshi en-aut-sei=Kuroda en-aut-mei=Shigetoshi kn-aut-name=黒田重利 kn-aut-sei=黒田 kn-aut-mei=重利 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=国立療養所南岡山病院神経内科･臨床研究部 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=3 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=4 en-affil= kn-affil=岡山市立市民病院神経内科 affil-num=5 en-affil= kn-affil=香川医科大学神経精神医学教室 affil-num=6 en-affil= kn-affil=国立療養所南岡山病院神経内科･臨床研究部 affil-num=7 en-affil= kn-affil=岡山大学医学部神経精神医学教室 en-keyword=側頭葉てんかん (temporal lobe epilepsy) kn-keyword=側頭葉てんかん (temporal lobe epilepsy) en-keyword=海馬委縮 (hippocampal atrophy) kn-keyword=海馬委縮 (hippocampal atrophy) en-keyword=罹病期間 (clinical history) kn-keyword=罹病期間 (clinical history) en-keyword=MRI kn-keyword=MRI en-keyword=発作間歇期脳波 (interictal EEG foci) kn-keyword=発作間歇期脳波 (interictal EEG foci) END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=23 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study on recording and analysis conditions of polysomnography for automated computer analysis of sleep stages. kn-title=睡眠ポリグラフ自動解析のための記録･解析条件の検討 en-subtitle= kn-subtitle= en-abstract=Recording and analysis conditions of polysomnography were examined in 10 young adult female by using sleep analysis computer Medilog SAC 847 system (Oxford). The quantity and percentage of slow wave sleep were consistent with those of visual inspection when the minimum delta amplitude was adjusted at ± 25～31μV from the baseline. The gain amplitude of mandibular electromyogram dramatically affected recognition of REM stage by the computer. Percentage of REM sleep was almost same as that of visual inspection when the gain potentiometer was adjusted to read 50μV peak-to-peak calibration signal as 1.0V, while REM stage was not recognized when　the gain potentiometer was adjusted to 1.5V. In contrast, the gain amplitude of electropthalmogram　did not affect the recognition of REM stage. kn-abstract=自動解析装置を用いて終夜睡眠ポリグラフを解析する際の記録条件と解析条件を検討した。対象は若年成人女性10名で,解析には0xford社製睡眠ポリグラフ記録･解析装置Medilog SAC 847 Systemを用い,第3夜の記録を視察判定と比較した｡徐波睡眠の指標となるδ波の最小振幅基準を初期設定の基線から±31/μVと,これより低い±25/μVに設定すると,徐波睡眠量,徐波睡眠率とも視察による判定とほぼ同じ解析結果が得られた。眼球運動の入力感度はREM睡眠量,REM睡眠率に影響しなかったが,オトガイ筋電図の入力感度を初期設定の1.5VにするとREM睡眠がほとんどみれなくなる例が多く,1.0VではREM睡眠量がこれまでの報告より少ないものの,視察判定に近い結果が得られた｡以上の研究結果から,我々が用いた自動解析装置では,オトガイ筋電図の入力感度を1.0V,δ波の最小振幅基準を±25～31/μVに設定すれば,視察判定とほぼ同じ解析結果が得られると考えられた｡ en-copyright= kn-copyright= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=岡本基 kn-aut-sei=岡本 kn-aut-mei=基 aut-affil-num=1 ORCID= en-aut-name=InoueMakiko en-aut-sei=Inoue en-aut-mei=Makiko kn-aut-name=井上真紀子 kn-aut-sei=井上 kn-aut-mei=真紀子 aut-affil-num=2 ORCID= en-aut-name=NakashimaMakiko en-aut-sei=Nakashima en-aut-mei=Makiko kn-aut-name=中島麻紀子 kn-aut-sei=中島 kn-aut-mei=麻紀子 aut-affil-num=3 ORCID= en-aut-name=ItoSekiko en-aut-sei=Ito en-aut-mei=Sekiko kn-aut-name=伊藤昔子 kn-aut-sei=伊藤 kn-aut-mei=昔子 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=2 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 affil-num=4 en-affil= kn-affil=岡山大学医療技術短期大学部衛生技術学科 en-keyword=睡眠 (sleep) kn-keyword=睡眠 (sleep) en-keyword=終夜ポリグラフ (polysomnography) kn-keyword=終夜ポリグラフ (polysomnography) en-keyword=自動解析 (automated computer analysis) kn-keyword=自動解析 (automated computer analysis) en-keyword=記録条件 (recording conditions) kn-keyword=記録条件 (recording conditions) en-keyword=解析条件 (analysis condition) kn-keyword=解析条件 (analysis condition) END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=2 article-no= start-page=105 end-page=111 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒスチジンタグを持つホスファカンコア蛋白の大腸菌での発現と精製 kn-title=Affinity purification of phosphacan core protein expressed in Escherichia coli as histidine-tagged fusion protein en-subtitle= kn-subtitle= en-abstract=コンドロイチン硫酸プロテオグリカンの一つであるホスファカンのコア蛋白の特定領域を,ヒスチジンタグ(His-tag)を持つ融合蛋白として大腸菌内で発現させニッケル-ニトリロ3酢酸(Ni-NTA)アフィニティ担体を用いて精製した｡ホスファカンコア蛋白のアミノ酸残基343-446(P3)及び1-340(P4)に相当するcDNA断片を,胎性18日目のラット脳由来のmRNAを鋳型としたPCRによって増幅した｡増幅された断片は発現ベクターpQE30に組み込まれ,これで大腸菌(M15[pREP4])を形質転換した｡His-tag融合蛋白の発現は形質転換株を1mM IPTG存在下で37℃,5時間培養することによって行われた｡His-tagged P3融合蛋白は可溶性蛋白質として発現し,Ni-NTA担体を用いて精製された.His-tagged P4融合蛋白は不溶性の封入体を形成したが,8M尿素によって可溶化され,変性条件下で同様に精製された｡ kn-abstract=Specific regions of core protein of phosphacan, one of the chondroitin sulfate proteoglycans, were expressed as fusion proteins with histidine-tag (His-tag) in Escherichia coli (E.coli) and were affinity purified using nickel-nitrilotriacetic acid (Ni-NTA) matrix. cDNA fragments encoding amino acid residues 343-446 (P3) and 1-340 (P4) of phosphacan core protein were amplified by polymerase chain reaction from E18 rat brain mRNA as template. The amplified products were subcloned into pQE30 vector and were introduced into E.coli strain M15 [pREP4] for the expression. The His-tagged fusion proteins were expressed by cultivating the transformants at 37℃ for 5h in the presence of 1mM IPTG. His-tagged P3 fusion protein (His-P3) was expressed as soluble form, and was purified using Ni-NTA matrix. His-tagged P4 fusion protein (His-P4) which was sequestered into insoluble inclusion bodies was treated with 8.0M urea to solubilize, and then was purified under denaturing conditions. en-copyright= kn-copyright= en-aut-name=ItoSekiko en-aut-sei=Ito en-aut-mei=Sekiko kn-aut-name=伊藤昔子 kn-aut-sei=伊藤 kn-aut-mei=昔子 aut-affil-num=1 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=岡本基 kn-aut-sei=岡本 kn-aut-mei=基 aut-affil-num=2 ORCID= en-aut-name=MoriShuji en-aut-sei=Mori en-aut-mei=Shuji kn-aut-name=森秀治 kn-aut-sei=森 kn-aut-mei=秀治 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科検査技術科学専攻 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科検査技術科学専攻 affil-num=3 en-affil= kn-affil=岡山大学医学部保健学科検査技術科学専攻 en-keyword=phosphacan (ホスファカン) kn-keyword=phosphacan (ホスファカン) en-keyword=core protein (コア蛋白) kn-keyword=core protein (コア蛋白) en-keyword=His-tagged proteins kn-keyword=His-tagged proteins en-keyword=recombinant protein (融合蛋白) kn-keyword=recombinant protein (融合蛋白) END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=2 article-no= start-page=91 end-page=104 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study on the correlation between the results of entrance examination and the academic record of the students in the department of laboratory technology kn-title=衛生技術学科入学者の高校評点,入学試験成績と入学後の学業成績の関係 ―入学者選抜,教育方法の改善に向けた自己点検･評価(1)― en-subtitle= kn-subtitle= en-abstract=The correlation between the school record in high school, result of entrance examination and the academic record, failure in promotion and withdrawal from school was examined in 361 students entered into department of laboratory technology from 1987 to 1995. 1) Thirty-nine students (10.8%) had failed in promotion, and 18 students (5%) had leaved from the school. The reason of withdrawal was refusal in 6 cases, and 4 students had changed their course to other universities. These cases were more frequent in the period until 1990 than in the period after 1991. 2) There were no differences in the school record in high school and the result of entrance examination among students who graduated scheduled period of attendance (regular students), those who failed in promotion, and those who had leaved the school. However, the students who failed in promotion had got higher score in entrance examination than regular students in 1987 and 1988. In contrast, regular students had got higher score in entrance examination than the students failed in promotion in 1991 and 1993. 3) The school record in high school could be cheked during the period from 1991 to1995. In this period, the students failed in promotion had got lower score in high school than regular students. Especially, the difference was significant in 1991 and 1993. 4) There was a significant positive correlation between the results in examination of general subjects and those in examination of technical and proffesional education. 5) The school records in high school had relatively weak positive correlation with the results of entrance examination. In contrast, both the school record in high school and result of entrance examination had clear positve correlations with both the results in examination of general subjects and technical and proffesional education. 6) However, the result of each subject of entrance examination, i.e. Japanese, Mathematics, English, and Science, had no or weak positive correlation with both the results in examination of general subjects and technical and proffesional education. 7) The students who had not passed the national examination of laboratory technologist had lower score in school record in high school, entrance examination, examination of general subjects and technical and proffesional education, but the diffenreces were not statistically significant. The results of the study indicate that there were students who failed in promotion or leaved school despite their excellent ability during four years following the establishment of School of Health Sciences, but thereafter the ability of students gradually became homogeneous and increased the students who failed in promotion because of insufficient ability. The highly positive correlation between the results in examination of general subjects and those in examination of technical and proffesional education indicate that the results of examination in the first year were directly reflected in the results of examination in second and third year, and that it is important to encourage the students's motivation and volition to study with ardor immediately after the entrance. The positive correlation of school record in high school and result of entrance examination with academic record after the entrance implicate the potential usefulness of school record in high school and result of entrance examination in determining the eligibility to enter the school. However, it is desirable to improve the subjects and problems of entrance examination because the result of each subject of entrance examination was poorly reflected in the academic record. kn-abstract=1987年4月から1995年4月の9年間に衛生技術学科へ入学した361名を対象に,高校評点,入学試験(学力試験)成績と,入学後の学業成績,退学,留年,臨床検査技師国家試験との関係を調べた｡ 1)入学者総数は361名で,このうち留年者が39名(10,8%),退学者が18名(5%)であった｡退学者の中には,実質入学辞退者が6名,4年制大学へ進路を変更した者が4名いたが,こうした退学者は1992年度までの入学者に多かった｡ 2)入学者全体では,予定卒業者,留年者,退学者の間で高校評点,入学試験成績には差がなかったが,入学年度ごとにみると,1987,1988年度は留年者が予定卒業者に比べて入学試験の総得点が高い傾向があり,逆に1991年,1993年度は予定卒業者に比べて有意に低かった｡ 3)高校評点は,データが入手できた1991年度以降一貫して留年者の評点が予定卒業者より低く, とくに1991年,1993年度は留年者の評点が有意に低かった｡ 4)留年者も含めて,一般教育科目の成績と専門科目の成績との間に有意を正の相関がみられた｡ 5)高校評点と入学試験成績との間には軽度の相関しかみられなかったが,高校評点および入学試験総合点は入学後の一般教育科目,専門科目の成績と高い正の相関を示した｡ 6)しかし,個々の入学試験科目の得点は,入学後の成績と相関しないか,軽度の相関しかみられなかった｡ 7)国家試験不合格者は,高校評点,入学試験総合点,一般科目平均点,専門科目平均点のいずれも合格者に比べて得点が低かったが,有意差はなかった｡以上の結果から,短期大学部開設当初は留年者,退学者の中に予定卒業者より学力のある学生がいたが,年を追うごとに入学者の学力が均質化し,学力が不十分なために留年する学生が多くなってきていると言える。一般教育科目の成績と専門科目の成績が強い正の相関を示すことは,1年次の成績がそのまま2,3年次の成績に反映されることを示しており,入学当初の動機付けと勉学意欲の喚起が重要なことを示している｡高校評点や学力試験の成績は入学後の成績とよく相関しており,学生選抜の有効な指標であると考えられたが,各入試科目との相関は乏しかったことから,個々の試験科目の問題内容については改善すべき課題があると思われた｡ en-copyright= kn-copyright= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=岡本基 kn-aut-sei=岡本 kn-aut-mei=基 aut-affil-num=1 ORCID= en-aut-name=SakiyamaJunko en-aut-sei=Sakiyama en-aut-mei=Junko kn-aut-name=崎山順子 kn-aut-sei=崎山 kn-aut-mei=順子 aut-affil-num=2 ORCID= en-aut-name=AkatsukaKazuya en-aut-sei=Akatsuka en-aut-mei=Kazuya kn-aut-name=赤塚和也 kn-aut-sei=赤塚 kn-aut-mei=和也 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科検査技術科学専攻 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科検査技術科学専攻 affil-num=3 en-affil= kn-affil=福山臨床検査センター en-keyword=高校評点 (school record in high school) kn-keyword=高校評点 (school record in high school) en-keyword=入学試験成績 (result of entrance examination) kn-keyword=入学試験成績 (result of entrance examination) en-keyword=入学後の学業成績 (academic record) kn-keyword=入学後の学業成績 (academic record) en-keyword=留年 (failure in promotion) kn-keyword=留年 (failure in promotion) en-keyword=退学 (withdrawal from school) kn-keyword=退学 (withdrawal from school) END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=1 article-no= start-page=63 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research on satisfaction of elderlies with dementia in health care facilities. kn-title=老人保健施設における痴呆老人の満足度調査 en-subtitle= kn-subtitle= en-abstract=The purpose of this study was to clarify if there is a relationship between the satisfaction of elderlies with dementia in health care facilities by subjective views of the investigator and their actions. The subjects of this investigation were 28 fully functional elderly clients with dementia who were living in 2 health care facilities. They or their family consented to take part in our research. 14 clients were chosen from each facilities. The investigators observed the clients for 48 hours and recorded where they were, with whom they were, what they did, as well as the client's level of satisfaction. The satisfaction levels were judged from the clients' appearances or attitudes by the investigations. There were five satisfaction including from 1 : unsatisfied to 5 : great satisfaction. The following three points were observed both in two facilities in common ; (1) the high satisfaction time period was "morning" when recreation was included. (2) the client received a high level of satisfaction when they were in the "recreation-room" or "outdoors", (3) the client received a high level of satisfaction whom they stayed with "their family" or "observers", when talking to someone or helping someone positively. Analysis of these results demonstrated there was similar pattern between the time of day and place and their companion or their actions among the subjects in two facilities. It can be assumed that it is able to observe elderlies with dementia satisfaction degree objectively. kn-abstract=2つの老人保健施設に入所している痴呆老人について,観察者による彼らの満足度とその時に観察された行動の関係を明らかにすることを目的とする｡調査対象者は,2つの老人保健施設に入所中で,本人または家族より調査への了系の得られた,歩行可能な痴呆老人各14名,合計28名である｡観察者は対象者の行動を48時間観察し,どこで誰と何を行っているかとその時の満足度を調査票に記録した｡満足度は対象者の表情や態度から観察者が判断し,大変満足を⑤とし,どちらとも言えないを③,大変不満足を①とした5段階評定で示した｡その結果以下の3点が明らかとなった｡ 1)両施設で満足度の高い時間帯は,レクリエーションが含まれる"午前中の時間"であった｡ 2)満足度が高いのは,居場所では,"レクリエーションルーム･屋外"であった｡ 3)同行者は,"家族","観察者",行動は,"話をする",手伝いをするなど"自発的な行為"が多くみられた｡以上により,2つの施設で満足度ごとの時間帯,居場所,同行者と行動が似通っていたことから,客観的に痴呆老人の満足度を把握することは可能であると考える｡ en-copyright= kn-copyright= en-aut-name=SumiyoshiKazuko en-aut-sei=Sumiyoshi en-aut-mei=Kazuko kn-aut-name=住吉和子 kn-aut-sei=住吉 kn-aut-mei=和子 aut-affil-num=1 ORCID= en-aut-name=KawataChieko en-aut-sei=Kawata en-aut-mei=Chieko kn-aut-name=川田智恵子 kn-aut-sei=川田 kn-aut-mei=智恵子 aut-affil-num=2 ORCID= en-aut-name=OkanoHatsue en-aut-sei=Okano en-aut-mei=Hatsue kn-aut-name=岡野初枝 kn-aut-sei=岡野 kn-aut-mei=初枝 aut-affil-num=3 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=岡本基 kn-aut-sei=岡本 kn-aut-mei=基 aut-affil-num=4 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=高橋聖之 kn-aut-sei=高橋 kn-aut-mei=聖之 aut-affil-num=5 ORCID= en-aut-name=MoriShuji en-aut-sei=Mori en-aut-mei=Shuji kn-aut-name=森秀治 kn-aut-sei=森 kn-aut-mei=秀治 aut-affil-num=6 ORCID= en-aut-name=TsujimotoHisae en-aut-sei=Tsujimoto en-aut-mei=Hisae kn-aut-name=辻本久江 kn-aut-sei=辻本 kn-aut-mei=久江 aut-affil-num=7 ORCID= en-aut-name=SueEiko en-aut-sei=Sue en-aut-mei=Eiko kn-aut-name=須江英子 kn-aut-sei=須江 kn-aut-mei=英子 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=3 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=4 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=5 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=6 en-affil= kn-affil=岡山大学医学部保健学科 affil-num=7 en-affil= kn-affil=老人保健施設白梅の丘 affil-num=8 en-affil= kn-affil=介護老人保健施設サンスクエア沼南 en-keyword=老人保健施設 (old people's health facilities) kn-keyword=老人保健施設 (old people's health facilities) en-keyword=痴呆老人 (elderlies with dementia) kn-keyword=痴呆老人 (elderlies with dementia) en-keyword=満足度 (satisfaction) kn-keyword=満足度 (satisfaction) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=9 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of Coicis semen and Rhizopus oligosporus-fermented Coicis semen (tempeh) on serum cholesterol in the rat kn-title=はとむぎ,はとむぎテンペのラットコレステロール代謝改善作用に関する研究 en-subtitle= kn-subtitle= en-abstract=The effect of Coicis semen and Rhizopus oligosporus-fermented Coicis semen (tempeh) on serum cholesterol fractions was examined in the rat. Twelve-week-old male Sprague-Dawley rats were received commercial MF meal (control group), Coicis semen-containing MF meal (Coicis semen group), or tempeh-containing MF meal (tempeh group). Cholesterol fractions were analyzed by high performance liquid chromatography at the start of experiment, and 2, 6, 18 weeks later. No difference was found in body weight nor total cholesterol among the three groups. LDL cholesterol was significantly lowered in the tempeh group at 2, 6, 18 weeks. LDL cholesterol/HDL cholesterol ratio also decreased at 2 and 18 weeks. In the both Coicis semen- and tempeh-fooded groups, LDL cholesterol and LDL cholesterol/HDL cholesterol ratio were lower than the control group although they were not statistically significant. No difference was found in HDL cholesterol among the three groups. The results suggest that tempeh may have a favorable effect on cholesterol metabolism. kn-abstract=はとむぎ(Coicis semen)をテンペ菌(Rhizopus oligosporus)で発酵したはとむぎテンペ(テンペ)の血清コレステロール代謝に対する作用を検討した｡生後12週齢のSprague-Dawley系雄ラットに市販固形飼料(コントロール群),はとむぎ混合飼料(はとむぎ群),テンペ混合飼料(テンペ群)を投与し,2,6,18週間後に高速液体クロマトグラフィー法で血清コレステロールを測定した｡体重増加,総コレステロールはいずれの時点でも3群間に差がなかったが,テンペ群では投与前と比較して2,6,18週間後にLDLコレステロールが有意に低下し,LDLコレステロール/HDLコレステロール比も2,18週間後に有意に低下した｡テンペ群はコントロール群と比較してもLDLコレステロールとLDLコレステロール/HDLコレステロール比が低く,はとむぎ群でも低い傾向がみられたが,有意差はなかった｡以上から,テンペがコレステロール代謝改善作用をもつことが示唆された｡ en-copyright= kn-copyright= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=岡本基 kn-aut-sei=岡本 kn-aut-mei=基 aut-affil-num=1 ORCID= en-aut-name=UsuiShinichi en-aut-sei=Usui en-aut-mei=Shinichi kn-aut-name=臼井真一 kn-aut-sei=臼井 kn-aut-mei=真一 aut-affil-num=2 ORCID= en-aut-name=OkazakiMitsuyo en-aut-sei=Okazaki en-aut-mei=Mitsuyo kn-aut-name=岡崎三代 kn-aut-sei=岡崎 kn-aut-mei=三代 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科検査技術科学専攻 affil-num=2 en-affil= kn-affil=岡山大学医学部保健学科検査技術科学専攻 affil-num=3 en-affil= kn-affil=東京医科歯科大学教養部 en-keyword=はとむぎ (Coicis semen) kn-keyword=はとむぎ (Coicis semen) en-keyword=はとむぎテンペ (Rhizopus oligosporus, tempeh) kn-keyword=はとむぎテンペ (Rhizopus oligosporus, tempeh) en-keyword=コレステロール (cholesterol) kn-keyword=コレステロール (cholesterol) en-keyword=ラット (rat) kn-keyword=ラット (rat) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=2 article-no= start-page=63 end-page=69 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Investigation of the tracheal suctioning-related microbialcolonization in home care patients with tracheotomy kn-title=気管内吸引を必要とする在宅療養患者の感染管理の実態 en-subtitle= kn-subtitle= en-abstract=Microbial colonization related to tracheal toilet was investigated in three home care patients who had tracheotomy with or without mechanical ventilation. We focused on the manipulation of suctioning tube to develop a effective and low-cost guidline for infection control. Tracheal suctioning was doned by wife in all the patients. Catheters used for suctioning was generally wiped with alcohol, washed in deionized or boiled water, and stored in alcohol-wiped container or immersed in 0.05% gluconate chlorhexizine. Catheter was changed into new one every 1.5 to 7 days. Samples were obtained from catheter, water used for washing, container as well as patients and their caregivers, and cultured on agar culture plate for Staphylococcus aureus, or Escherichia coli. Colonization of gauze around tracheotomy and water used for washing was detected in two patinets. E. coli and S. aureus were common organism colonizing gauze around tracheotomy. Therefore, it was suggested that the manipulation of the tracheal suctioning in home care influence on microbial colonization. kn-abstract=気管内吸引を必要とする在宅療養患者に対し,安全で経済的な感染管理方法を検討するため,在宅ケアにおける気管内吸引の実態と,吸引関連物品の細菌学的調査を実施した。対象は気管切開がされ,医療依存度の高い患者3名であり,気管内吸引は全て患者の妻が行っていた。吸引後のカテーテルは外側をアルコール綿で清拭し,内腔を洗浄水で洗浄していた。カテーテルは,0.05%グルコン酸クロルヘキシジンに浸漬あるいは,清潔な乾燥容器に保管されていた。カテーテルの交換時期は,1.5日から7日とばらつきがあった。カテーテル,洗浄水,浸潰液等の試料を,一般細菌,黄色ブドウ球菌,大腸菌群の寒天培地で培養したところ,各試料から一般細菌,黄色ブドウ球菌,大腸菌群が検出されたが,カテーテルの保管方法の違いによる細菌汚染に差は認められなかった｡また,気管切開部ガーゼからは,一般細菌,黄色ブドウ球菌,大腸菌群が検出された｡これらより,気管内吸引カテーテルおよび,洗浄水や浸溝用消毒液の清潔管理の必要性が示唆された｡ en-copyright= kn-copyright= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name=渡邉久美 kn-aut-sei=渡邉 kn-aut-mei=久美 aut-affil-num=1 ORCID= en-aut-name=KanzakiHitomi en-aut-sei=Kanzaki en-aut-mei=Hitomi kn-aut-name=菅崎仁美 kn-aut-sei=菅崎 kn-aut-mei=仁美 aut-affil-num=2 ORCID= en-aut-name=SendaYoshiko en-aut-sei=Senda en-aut-mei=Yoshiko kn-aut-name=千田好子 kn-aut-sei=千田 kn-aut-mei=好子 aut-affil-num=3 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=岡本基 kn-aut-sei=岡本 kn-aut-mei=基 aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=2 en-affil= kn-affil=岡山訪問看護ステーション看護協会 affil-num=3 en-affil= kn-affil=岡山大学医学部保健学科看護学専攻 affil-num=4 en-affil= kn-affil=岡山大学医学部保健学科検査技術科学専攻 en-keyword=感染管理 (Infection control) kn-keyword=感染管理 (Infection control) en-keyword=気管内吸引 (tracheal suctioning) kn-keyword=気管内吸引 (tracheal suctioning) en-keyword=在宅ケア (home care) kn-keyword=在宅ケア (home care) en-keyword=介護者 (caregiver) kn-keyword=介護者 (caregiver) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=33 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Morphology and Anatomy of Holocene Raised Coral Reef Terraces in Kodakara Island, Tokara Islands, northwestern Pacific, Japan kn-title=吐喝喇列島・小宝島の完新世隆起サンゴ礁段丘地形と堆積構造 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Well-developed Holocene raised coral reef terraces are formed in Kodakara Island (29°13'N 129°19'E), Tokara Islands, northwestern Pacific, Japan. Detailed morphology and sedimentary structure of the raised reef terraces are observed by field survey through the terraces surface and core drillings. The Holocene raised reef in Kodakara Island are divided into three terraces (TI to III). The surface geo-biological facies and paleo-morphology such as spur and groove system or reef mounds are well preserved on these terraces. The raised coral reefs in Kodakara Island consist of reef flats and reef slopes. No lagoon formed in these terraces. On the raised reef surface, we observed five distinct reefal facies (S-f1-5). The platy and encrusting Acropora facies is the major constituent of the terrace surfaces. We obtained seven drilling cores (B1 to 7) from Terraces I and II along a transect in the southern part of the island. The thickness of the Holocene reef is more than 14m which is approximately equivalent to the Holocene reefs in the middle and southern Ryukyu Islands. Sedimentary structure consists of seven facies (C-f1-7: five reefal and two non-reefal facies). The drilling cores indicating the shallowing sequence at the upward of the cores which characterized by platy-encrusting Acropora facies overlying massive Porites, favid and/or encrusting-foliaceous coral facies. It may indicate the environmental change such as wave-energy gradients and turbidity during the reef development. en-copyright= kn-copyright= en-aut-name=HamanakaNozomu en-aut-sei=Hamanaka en-aut-mei=Nozomu kn-aut-name=濱中望 kn-aut-sei=濱中 kn-aut-mei=望 aut-affil-num=1 ORCID= en-aut-name=KanHironobu en-aut-sei=Kan en-aut-mei=Hironobu kn-aut-name=菅浩伸 kn-aut-sei=菅 kn-aut-mei=浩伸 aut-affil-num=2 ORCID= en-aut-name=NakashimaYosuke en-aut-sei=Nakashima en-aut-mei=Yosuke kn-aut-name=中島洋典 kn-aut-sei=中島 kn-aut-mei=洋典 aut-affil-num=3 ORCID= en-aut-name=HoriNobuyuki en-aut-sei=Hori en-aut-mei=Nobuyuki kn-aut-name=堀信行 kn-aut-sei=堀 kn-aut-mei=信行 aut-affil-num=4 ORCID= en-aut-name=OkamotoTakehiro en-aut-sei=Okamoto en-aut-mei=Takehiro kn-aut-name=岡本健裕 kn-aut-sei=岡本 kn-aut-mei=健裕 aut-affil-num=5 ORCID= en-aut-name=OhashiTomoya en-aut-sei=Ohashi en-aut-mei=Tomoya kn-aut-name=大橋倫也 kn-aut-sei=大橋 kn-aut-mei=倫也 aut-affil-num=6 ORCID= en-aut-name=AdachiHiroshi en-aut-sei=Adachi en-aut-mei=Hiroshi kn-aut-name=安達寛 kn-aut-sei=安達 kn-aut-mei=寛 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 affil-num=2 en-affil= kn-affil=岡山大学 affil-num=3 en-affil= kn-affil=有明工業高等専門学校 affil-num=4 en-affil= kn-affil=奈良大学 affil-num=5 en-affil= kn-affil=岡山大学 affil-num=6 en-affil= kn-affil=岡山大学 affil-num=7 en-affil= kn-affil=(株)ジオアクト en-keyword=Holocene kn-keyword=Holocene en-keyword=coral reef terrace kn-keyword=coral reef terrace en-keyword=drilling kn-keyword=drilling en-keyword=sedimentary structure kn-keyword=sedimentary structure en-keyword=Tokara Islands kn-keyword=Tokara Islands en-keyword=northwestern Pacific kn-keyword=northwestern Pacific END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=107 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Three cases of rheumatoid arthritis with biliary tract cancer kn-title=慢性関節リウマチに胆道系悪性腫瘍を合併した3例 en-subtitle= kn-subtitle= en-abstract=The relationships between rheumatoid arthritis and malignant disease have been a focus of controversy for many years. Many studies of patients with rheumatoid arthritis have found no increases in overall cancer rates. Although significant elevations in rates of lymphoma, myeloma and malignant disease in patients treated with immunosuppressive drugs have been reported, it has been considered that gastrointestinal and biliary tract cancer in patients with rheumatoid arthritis is rare. We recently experienced three cases of rheumatoid arthritis with biliary tract cancer. They were gall bladder, cancer, bile duct cancer and cancer of papilla of Vater. Patients with rheumatoid arthritis should be carefully monitored for malignant disease. kn-abstract=一般的に,慢性関節リウマチには悪性腫瘍の合併は少ないと言われている｡特に,消化器系あるいは胆道系悪性腫瘍を合併したという報告は極めて少ない｡我々は慢性関節リウマチの経過中,胆道系悪性腫瘍を合併した3例を経験した｡3症例はそれぞれ胆嚢癌,肝内胆管癌,乳頭部癌を合併していた｡非常に稀な症例であり,文献的考案を含め報告する｡ en-copyright= kn-copyright= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=岩垣尚史 kn-aut-sei=岩垣 kn-aut-mei=尚史 aut-affil-num=1 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=5 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=慢性関節リウマチ (rheumatoid arthritis) kn-keyword=慢性関節リウマチ (rheumatoid arthritis) en-keyword=胆道系悪性腫瘍 (biliary tract cancer) kn-keyword=胆道系悪性腫瘍 (biliary tract cancer) en-keyword=胆嚢癌 (gall bladder cancer) kn-keyword=胆嚢癌 (gall bladder cancer) en-keyword=胆管癌 (bile duct cancer) kn-keyword=胆管癌 (bile duct cancer) en-keyword=乳頭部癌 (cancer of papilla of Vater) kn-keyword=乳頭部癌 (cancer of papilla of Vater) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=99 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diet therapy with α-linolenic acid-enriched perilla seed oil on pulmonary emphysema. kn-title=n-3系脂肪酸を強化した食事療法が有効と考えられた肺気腫の一例 en-subtitle= kn-subtitle= en-abstract=An effective treatment of advanced stages of chronic obstructive pulmonary disease (COPD) has not been estadlished yet. We report out recent experience of one patient with pulmonary emphysema treated with dietary supplementation with n-3 fatty acid for two months. He presented improvements in clinical symptoms and pulmonary function, and suppression in generation of leukotriene B(4) (LTB(4) )by peripheral leukocytes. Weconsequently suppose that dietary treatment with n-3 fatty acids (perilla seed oil) may be beneficial for the treatment of pulmonary emphysema by inhibiting the conversion of arachidonic acid (AA) to leukotrienes (LTs) and prostanoids competitively. kn-abstract=症例は67歳,男性｡主訴は労作時呼吸困難｡【第一回目入院】平成7年9月から12月まで入院し,薬物療法,複合温泉療法を行なった｡自覚症状はやや改善がみられたが,呼吸機能検査所見の改善は得られなかった｡【第二回目入院】平成8年8月から12月まで入院｡n-3系脂肪酸強化食事療法も併用した｡自覚症状および,呼吸機能検査上,FVC,FEV(1.0),PEFなどに改善を認めた｡n-3系脂肪酸はアラキドン酸代謝を通してロイコトリエン合成に関与すると推定されるが,経過中に白血球のLTB(4)産生能の減少を認めた。この症例は肺気腫に対するn-3系脂肪酸強化食事療法の有用性が示唆され,病態を考える上でも興味深いと考えられたので報告する。 en-copyright= kn-copyright= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=1 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=4 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=5 ORCID= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=岩垣尚史 kn-aut-sei=岩垣 kn-aut-mei=尚史 aut-affil-num=6 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=7 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=辻孝夫 kn-aut-sei=辻 kn-aut-mei=孝夫 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部第一内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=肺気腫 (pulmonary emphysema) kn-keyword=肺気腫 (pulmonary emphysema) en-keyword=n-3系脂肪酸 (n-3 fatty acid) kn-keyword=n-3系脂肪酸 (n-3 fatty acid) en-keyword=食事療法 (diet therapy) kn-keyword=食事療法 (diet therapy) en-keyword=ロイコトリエン合成 (leukotriene) kn-keyword=ロイコトリエン合成 (leukotriene) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=80 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=呼吸器疾患のリハビリテーション.気管支喘息の病態的特徴と関連した温泉療法の効果 kn-title=Rehabilitation for patients with respiratory disease. Spa efficacy in relation to pathophysiological characteristics of bronchial asthma. en-subtitle= kn-subtitle= en-abstract=近年老年者の呼吸器疾患が増加しつつある｡老年者の呼吸器疾患の病態的特徴は若年者のそれとは明らかに異なっている｡本論文では,老年者の呼吸器疾患,なかでも気管支喘息に対する温泉療法を中心としたリ-ビリテ-ションについて,その病態的特徴と関連して若干の知見を述べる｡複合温泉療法は2つの作用,すなわち直接作用と間接作用を有している｡患者の自,他覚症状は1-2カ月の温泉療法により明らかに改善傾向を示すが,同時に,換気機能の改善,気道過敏性や気道抵抗の低下が観察される｡これらの温泉療法の直接作用のはか,呼吸筋の増強,自律神経系の安定化,精神的リラックス,低下した副腎皮質機能の改善,などの間接作用も観察される｡気道の病態生理的特徴より分類した喘息の臨床病型に関しては,過分泌や細気管支閉塞を伴うような病 型に対して,温泉療法は有効性が高い｡これらの結果は,複合温泉療法が呼吸器疾患の治療ないしリハビリテーションとして有用であることを示している｡ kn-abstract=The number of patients with respiratory disease in the elderly has been increasing in recent years. Pathophysiological characteristic of respiratory diseases in older patients is clearly different from that in younger patients. In this study, rehabilitation for patients with respiratory disease, particularly bronchial asthma, in the elderly was discussed in relation to pathophysiology of asthma. Complex spa therapy has two kinds of actions, direct and indirect actions. Subjective and objective symptoms of patients with asthma are improved by spa therapy for 1-2 months, accompanied with improvement of ventilatory function, and decrease in bronchial hyperresponsiveness and respiratory resistance. In addition to these direct action of spa therapy, increase in strength of respiratory muscle, stability of autonomic nerve syetem, psychical relaxation, and inprovement of suppressed function of adrenocortical glands are observed as indirect action of spa therapy. Regarding clinical asthma type classified by pathophysiological changes of the airways, spa therapy was more effective in patients with hypersecretion and bronchiolar obstruction. These results suggest that complex spa therapy is available as rehabilitation and/or treatment for patients with respiratory disease. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=7 ORCID= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=岩垣尚志 kn-aut-sei=岩垣 kn-aut-mei=尚志 aut-affil-num=8 ORCID= en-aut-name=YamamotoKazuhiko en-aut-sei=Yamamoto en-aut-mei=Kazuhiko kn-aut-name=山本和彦 kn-aut-sei=山本 kn-aut-mei=和彦 aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 en-keyword=気管支喘息 (Bronchial asthma) kn-keyword=気管支喘息 (Bronchial asthma) en-keyword=リハビリテーション (rehabilitation) kn-keyword=リハビリテーション (rehabilitation) en-keyword=複合温泉療法 (complex spa therapy) kn-keyword=複合温泉療法 (complex spa therapy) en-keyword=換気機能 (ventilatory function) kn-keyword=換気機能 (ventilatory function) en-keyword=副腎皮質 (adrenocortical glands) kn-keyword=副腎皮質 (adrenocortical glands) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=51 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical effect of spa therapy on lumbargo kn-title=腰痛症に対する温泉療法の効果 en-subtitle= kn-subtitle= en-abstract=Clinical effect of spa therapy was evaluated in 12 patients with lumbargo by a scoring system based on the standard judgement of therapy for lumbargo by Japanese Society of Orthopedics. The score for each category of subjective symptoms, objective symptoms, daily life activity, and disorder of urinary bladder, and total score calculated from each score were compared before and after spa therapy. A significant improvement of subjective symptoms, daily life activity, and total score was observed after spa therapy. However objective symptom was not significantly improved. The effects of spa therapy was larger in patients under age of 65, and in those who had long-term spa therapy more than 80 days during their admission. The results suggest that spa therapy IS effective for patients with lumbargo. kn-abstract=腰痛症患者12例を対象に温泉療法の臨床効果について検討した｡臨床効果の判定は,日本整形外科学会の腰痛治療成績判定基準に基づき,自覚症状,他覚症状,及び日常生活動作などの項目を中心に,治療前後で比較検討した｡その結果,自覚症状,日常生活動作,総計では,治療前に比べ治療後に有意の改善がみられた｡また改善指数や改善率での検討でも温泉療法の有効性が示唆された｡年齢別(60才以上と60才未満),入院期間(80日以上と80日未満)別の 検討では,65才未満の症例,80日以上の入院の症例において,改善指数,改善率が,有意差はみられなかったもののより高い傾向がみられた｡ en-copyright= kn-copyright= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=岡本誠 kn-aut-sei=岡本 kn-aut-mei=誠 aut-affil-num=1 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=芦田耕三 kn-aut-sei=芦田 kn-aut-mei=耕三 aut-affil-num=2 ORCID= en-aut-name=YamamotoKazuhiko en-aut-sei=Yamamoto en-aut-mei=Kazuhiko kn-aut-name=山本和彦 kn-aut-sei=山本 kn-aut-mei=和彦 aut-affil-num=3 ORCID= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=岩垣尚史 kn-aut-sei=岩垣 kn-aut-mei=尚史 aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=柘野浩史 kn-aut-sei=柘野 kn-aut-mei=浩史 aut-affil-num=5 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=保崎泰弘 kn-aut-sei=保崎 kn-aut-mei=泰弘 aut-affil-num=6 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=御舩尚志 kn-aut-sei=御舩 kn-aut-mei=尚志 aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=光延文裕 kn-aut-sei=光延 kn-aut-mei=文裕 aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=谷崎勝朗 kn-aut-sei=谷崎 kn-aut-mei=勝朗 aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=多田慎也 kn-aut-sei=多田 kn-aut-mei=慎也 aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=原田実根 kn-aut-sei=原田 kn-aut-mei=実根 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=2 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=3 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=4 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=5 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=6 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=7 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=8 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=9 en-affil= kn-affil=岡山大学医学部附属病院三朝分院内科 affil-num=10 en-affil= kn-affil=岡山大学医学部第二内科 affil-num=11 en-affil= kn-affil=岡山大学医学部第二内科 en-keyword=腰痛症 (lumbargo) kn-keyword=腰痛症 (lumbargo) en-keyword=温泉療法 (spa therapy) kn-keyword=温泉療法 (spa therapy) en-keyword=腰痛治療判定基準 (scoring system based on the standard judgement of therapy for lumbargo) kn-keyword=腰痛治療判定基準 (scoring system based on the standard judgement of therapy for lumbargo) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=45 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=気管支喘息患者における腰椎海綿骨骨塩量と脊椎圧迫骨折の臨床的特徴 kn-title=Determinants of trabecular bone mineral density of the lumber spines and vertebral fracture in patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=対象は気管支喘息75症例｡このうち44例はステロイド依存性難治症例であった｡35症例については,0.5年から4年間(平均:2.6±1.3年間)の経時的観察もおこなわれた｡これらの症例の骨塩量に影響を及ぼす因子について検討をおこなった｡高齢者,女性に有意な低骨塩量を認めた｡重回帰分析にて年齢,性別,経口副腎ステロイド投与総量などの項目に骨塩量と有意な関連が認められた｡また,35症例中5例に脊椎圧迫骨折が発生し,いずれも骨塩量が低く,高齢者,女性,長期ステロイド内服例であった｡これらのことから気管支喘息患者においては,女性,高齢者,長期ステロイド内服例に骨塩量減少や脊椎圧迫骨折のリスクが高いと考えられた｡また,ステロイド続発性骨粗鬆症の発生には,ステロイドの現在の一日内服量よりもこれまでの総積算内服量が重要と考えられた｡ kn-abstract=Clinical risk factors associated with the development of osteoporosis and vertebral fractures were evaluated in patients with asthma in relation to sex, age, and dose of glucocorticoids (GC). In 75 asthmatic patients including 44 steroid-dependent asthma, the bone mineral density (BMD) of the lumber spines was measured by quantitative computed tomography (QCT). Thirty five patients of them were followed up with radiographs over a period of 0.5 to 4 years (average: 2.6±1.3 years). The BMD was significantly lower in older (p