start-ver=1.4 cd-journal=joma no-vol=137 cd-vols= no-issue=1 article-no= start-page=25 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The advances in robot-assisted surgery in the field of urology and future perspective kn-title=”å”AŠí‰È—̈æ‚É‚¨‚¯‚郃{ƒbƒgŽèp‚Ìi‰»‚Æ–¢—ˆ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=BekkuKensuke en-aut-sei=Bekku en-aut-mei=Kensuke kn-aut-name=•Ê‹{Œª‰î kn-aut-sei=•Ê‹{ kn-aut-mei=Œª‰î aut-affil-num=1 ORCID= en-aut-name=NagasakiNaoya en-aut-sei=Nagasaki en-aut-mei=Naoya kn-aut-name=’·ú±’¼–ç kn-aut-sei=’·ú± kn-aut-mei=’¼–ç aut-affil-num=2 ORCID= en-aut-name=OkamotoYusuke en-aut-sei=Okamoto en-aut-mei=Yusuke kn-aut-name=‰ª–{—I—C kn-aut-sei=‰ª–{ kn-aut-mei=—I—C aut-affil-num=3 ORCID= en-aut-name=ShiraishiHiromasa en-aut-sei=Shiraishi en-aut-mei=Hiromasa kn-aut-name=”’ΗT‰ë kn-aut-sei=”’Î kn-aut-mei=—T‰ë aut-affil-num=4 ORCID= en-aut-name=TairaAya en-aut-sei=Taira en-aut-mei=Aya kn-aut-name=•½—ÇÊ kn-aut-sei=•½—Ç kn-aut-mei=Ê aut-affil-num=5 ORCID= en-aut-name=InoueShota en-aut-sei=Inoue en-aut-mei=Shota kn-aut-name=ˆäããÄ‘¾ kn-aut-sei=ˆäã kn-aut-mei=ãÄ‘¾ aut-affil-num=6 ORCID= en-aut-name=KawagoYuya en-aut-sei=Kawago en-aut-mei=Yuya kn-aut-name=쇗T–ç kn-aut-sei=ì‡ kn-aut-mei=—T–ç aut-affil-num=7 ORCID= en-aut-name=WatanabeTomofumi en-aut-sei=Watanabe en-aut-mei=Tomofumi kn-aut-name=“n•”’q•¶ kn-aut-sei=“n•” kn-aut-mei=’q•¶ aut-affil-num=8 ORCID= en-aut-name=MitsuiMasao en-aut-sei=Mitsui en-aut-mei=Masao kn-aut-name=ŽOˆä›’—Y kn-aut-sei=ŽOˆä kn-aut-mei=›’—Y aut-affil-num=9 ORCID= en-aut-name=HoriiSatoshi en-aut-sei=Horii en-aut-mei=Satoshi kn-aut-name=–xˆä‘ kn-aut-sei=–xˆä kn-aut-mei=‘ aut-affil-num=10 ORCID= en-aut-name=MoriwakeTakatoshi en-aut-sei=Moriwake en-aut-mei=Takatoshi kn-aut-name=X•ª‹Mr kn-aut-sei=X•ª kn-aut-mei=‹Mr aut-affil-num=11 ORCID= en-aut-name=YoshinagaKasumi en-aut-sei=Yoshinaga en-aut-mei=Kasumi kn-aut-name=‹g‰iŸ kn-aut-sei=‹g‰i kn-aut-mei=Ÿ aut-affil-num=12 ORCID= en-aut-name=MitsuiYosuke en-aut-sei=Mitsui en-aut-mei=Yosuke kn-aut-name=Œõˆä—m‰î kn-aut-sei=Œõˆä kn-aut-mei=—m‰î aut-affil-num=13 ORCID= en-aut-name=YamanoiTomoaki en-aut-sei=Yamanoi en-aut-mei=Tomoaki kn-aut-name=ŽR–ìˆä—Fº kn-aut-sei=ŽR–ìˆä kn-aut-mei=—Fº aut-affil-num=14 ORCID= en-aut-name=KawadaTatsushi en-aut-sei=Kawada en-aut-mei=Tatsushi kn-aut-name=‰Í“c’BŽu kn-aut-sei=‰Í“c kn-aut-mei=’BŽu aut-affil-num=15 ORCID= en-aut-name=SadahiraTakuya en-aut-sei=Sadahira en-aut-mei=Takuya kn-aut-name=’蕽‘ì–ç kn-aut-sei=’蕽 kn-aut-mei=‘ì–ç aut-affil-num=16 ORCID= en-aut-name=TominagaYusuke en-aut-sei=Tominaga en-aut-mei=Yusuke kn-aut-name=•x‰i—I‰î kn-aut-sei=•x‰i kn-aut-mei=—I‰î aut-affil-num=17 ORCID= en-aut-name=IwataTakehiro en-aut-sei=Iwata en-aut-mei=Takehiro kn-aut-name=Šâ“cŒ’G kn-aut-sei=Šâ“c kn-aut-mei=Œ’G aut-affil-num=18 ORCID= en-aut-name=KatayamaSatoshi en-aut-sei=Katayama en-aut-mei=Satoshi kn-aut-name=•ÐŽR‘ kn-aut-sei=•ÐŽR kn-aut-mei=‘ aut-affil-num=19 ORCID= en-aut-name=NishimuraShingo en-aut-sei=Nishimura en-aut-mei=Shingo kn-aut-name=¼‘ºTŒá kn-aut-sei=¼‘º kn-aut-mei=TŒá aut-affil-num=20 ORCID= en-aut-name=EdamuraKohei en-aut-sei=Edamura en-aut-mei=Kohei kn-aut-name=Ž}‘ºN•½ kn-aut-sei=Ž}‘º kn-aut-mei=N•½ aut-affil-num=21 ORCID= en-aut-name=KobayashiTomoko en-aut-sei=Kobayashi en-aut-mei=Tomoko kn-aut-name=¬—Ñ’mŽq kn-aut-sei=¬—Ñ kn-aut-mei=’mŽq aut-affil-num=22 ORCID= en-aut-name=ArakiMotoo en-aut-sei=Araki en-aut-mei=Motoo kn-aut-name=r–ØŒ³˜N kn-aut-sei=r–Ø kn-aut-mei=Œ³˜N aut-affil-num=23 ORCID= affil-num=1 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=2 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=3 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=4 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=5 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=6 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=7 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=8 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=9 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=10 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=11 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=12 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=13 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=14 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=15 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=16 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=17 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=18 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=19 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=20 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=21 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=22 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw affil-num=23 en-affil=Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@”å”AŠí•a‘ÔŠw en-keyword=ƒƒ{ƒbƒgŽèp kn-keyword=ƒƒ{ƒbƒgŽèp en-keyword=ƒ_ƒrƒ“ƒ` kn-keyword=ƒ_ƒrƒ“ƒ` en-keyword=”å”AŠí‰È—̈æ kn-keyword=”å”AŠí‰È—̈æ END start-ver=1.4 cd-journal=joma no-vol=21 cd-vols= no-issue= article-no= start-page=670 end-page=679 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photochemically assisted synthesis of phenacenes fluorinated at the terminal benzene rings and their electronic spectra en-subtitle= kn-subtitle= en-abstract= kn-abstract=[n]Phenacenes ([n] = 5-7), octafluorinated at the terminal benzene rings (F8-phenacenes: F8PIC, F8FUL, and F87PHEN), were photochemically synthesized, and their electronic spectra were investigated to reveal the effects of the fluorination on the electronic features of phenacene molecules. F8-Phenacenes were conveniently synthesized by the Mallory photoreaction of the corresponding fluorinated diarylethenes as the key step. Upon fluorination on the phenacene cores, the absorption and fluorescence bands of the F8-phenacenes in CHCl3 systematically red-shifted by ca. 3-5 nm compared to those of the corresponding parent phenacenes. The vibrational progressions of the absorption and fluorescence bands were little affected by the fluorination in the solution phase. In the solid state, the absorption band of F8-phenacenes appeared in the similar wavelength region for the corresponding parent phenacenes whereas their fluorescence bands markedly red-shifted and broadened. These observations suggest that the intermolecular interactions of excited-state F8-phenacene molecules are significantly different from those of the corresponding parent molecules, most likely due to different crystalline packing motifs. en-copyright= kn-copyright= en-aut-name=IshiiYuuki en-aut-sei=Ishii en-aut-mei=Yuuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=3 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=4 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=5 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=fluorescence kn-keyword=fluorescence en-keyword=fluorinated aromatics kn-keyword=fluorinated aromatics en-keyword=phenacene kn-keyword=phenacene en-keyword=photoreaction kn-keyword=photoreaction END start-ver=1.4 cd-journal=joma no-vol=188 cd-vols= no-issue= article-no= start-page=67 end-page=76 dt-received= dt-revised= dt-accepted= dt-pub-year=2025 dt-pub=20250228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Music Education Practice Based on the Region: An Improvisation Workshop at a Public Elementary School in Tamano City, Okayama kn-title=’nˆæ‚ðŒ©‚Â‚ß’¼‚·‰¹Šy‹³ˆçŽÀ‘H‚ÌŒŸ“¢ \ ‰ªŽRŒ§‹Ê–ìŽs“à‚ÌŒö—§¬ŠwZ‚É‚¨‚¯‚鑦‹»‰‰‘tƒ[ƒNƒVƒ‡ƒbƒv‚ð—á‚É \ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@–{Œ¤‹†‚ÍC’nˆæ‚Ì•¶‰»‚âˆâŽYCŠÂ‹«‚ð”O“ª‚É’u‚¢‚½‘n‘¢“I‚ȉ¹Šy‹³ˆç‚É‚æ‚Á‚ÄCŒ§“à‚ÌlŒûŒ¸­‚É‹Nˆö‚·‚é‰Û‘è‚̉ü‘P‚ð}‚邱‚Æ‚ð–Ú“I‚Æ‚µ‚Ä‚¢‚éB“¯Žž‚ÉC‚»‚Ì‘n싳ˆç‚ð’Ê‚¶‚ÄCŽ™“¶‚Ì_“î‚È‘n‘¢—͂⑽—l«‚ð”F‚ß‚éˆÓŽ¯‚ðˆç‚Þ‚±‚Æ‚à‚Ë‚ç‚Á‚Ä‚¢‚éB–{Œ¤‹†‚É‚¨‚¢‚ÄŽÀ‘H‚µ‚½Žæ‘g‚ÍCŒ»‘㉹Šy“I•\Œ»‚ðŽæ‚è“ü‚ꂽ‘¦‹»‰‰‘tƒ[ƒNƒVƒ‡ƒbƒv‚Å‚ ‚éB
@–{e‚Å‚Í2024 ”N‚És‚Á‚½‹Ê–ìŽs“à‚̬ŠwZ‚É‚¨‚¯‚éƒ[ƒNƒVƒ‡ƒbƒv‚Ì“à—e‚ð’†S‚ɘ_‚¶‚éB–{ƒ[ƒNƒVƒ‡ƒbƒv‚ÍCŽ™“¶‚ª_“î‚©‚‘½—l‚È‘nì•\Œ»‚ðŽÀ‘H‚·‚éê‚Æ‚È‚Á‚½‚ªCŽ™“¶‚Æ’nˆæZ–¯‚炪‚»‚Ì’nˆæ‚Ì“ÁF‚ð”FŽ¯‚·‚é‹@‰ï‚Æ‚µ‚Ä‚ÍV‚½‚ȉۑè‚ð¶‚ñ‚¾B’nˆæ‚Æ‘n‘¢“I‰¹Šy‹³ˆç‚ðŒ‹‚ñ‚¾Œ¤‹†‚ÍŽÀ—Ⴊ­‚È‚­C–Íõ‚Ì’iŠK‚Å‚ ‚邽‚ßC–{ƒ[ƒNƒVƒ‡ƒbƒv‚ðÈ‚Ý‚½ã‚Å¡Œã‚̉ü‘P‚ÉŒq‚°‚½‚¢B en-copyright= kn-copyright= en-aut-name=OKAMOTOShinsuke en-aut-sei=OKAMOTO en-aut-mei=Shinsuke kn-aut-name=‰ª–{L‰î kn-aut-sei=‰ª–{ kn-aut-mei=L‰î aut-affil-num=1 ORCID= en-aut-name=MASUDAKenta en-aut-sei=MASUDA en-aut-mei=Kenta kn-aut-name=‘“cŒš‘¾ kn-aut-sei=‘“c kn-aut-mei=Œš‘¾ aut-affil-num=2 ORCID= affil-num=1 en-affil=Faculty of Education, Okayama University kn-affil=‰ªŽR‘åŠwŠwpŒ¤‹†‰@‹³ˆçŠwˆæ affil-num=2 en-affil=Faculty of Education, University of Toyama kn-affil=•xŽR‘åŠwŠwpŒ¤‹†•”‹³ˆçŠwŒn en-keyword=‰¹Šy‹³ˆç kn-keyword=‰¹Šy‹³ˆç en-keyword=’nˆæ‹³ˆç kn-keyword=’nˆæ‹³ˆç en-keyword=‘¦‹»‰‰‘t kn-keyword=‘¦‹»‰‰‘t en-keyword=ì‹È kn-keyword=ì‹È en-keyword=Œ»‘㉹Šy kn-keyword=Œ»‘㉹Šy END start-ver=1.4 cd-journal=joma no-vol=222 cd-vols= no-issue= article-no= start-page=115374 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Environmental water in Kolkata is suitable for the survival of Vibrio cholerae O1 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Many patients with cholera emerge in Kolkata, India throughout the year. Such emergency indicates that cholera toxin-producing Vibrio cholerae O1 (toxigenic V. cholerae O1) are widespread in Kolkata. This suggests that the suitable conditions for replication of toxigenic V. cholerae O1 is provided in Kolkata. In previous studies, we found that the replication rate of toxigenic V. cholerae O1 is low in the low ionic aqueous solution. Then we measured the ion concentration in the environmental water of Kolkata. As a control, we measured them in Japanese environmental water. The ion concentration in the environmental water of Kolkata was significantly high. Then, we examined the survival of toxigenic V. cholerae O1 in groundwater from Kolkata and found that V. cholerae O1 survive for long time in the solution but not in the solution diluted with Milli Q water. In addition, we found that V. cholerae O1 proliferated in environmental water of Kolkata to which a small amount of nutrient was added, but did not grow in the environmental water diluted with water to which the same amount of nutrient was added. These results indicate that the environmental water from Kolkata is suitable for survival of V. cholerae O1. en-copyright= kn-copyright= en-aut-name=TakahashiEizo en-aut-sei=Takahashi en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ChowdhuryGoutam en-aut-sei=Chowdhury en-aut-mei=Goutam kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MukhopadhyayAsish K. en-aut-sei=Mukhopadhyay en-aut-mei=Asish K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=DuttaShanta en-aut-sei=Dutta en-aut-mei=Shanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OchiSadayuki en-aut-sei=Ochi en-aut-mei=Sadayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=2 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= affil-num=4 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=5 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=6 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=7 en-affil=Department of Health Pharmacy, Yokohama University of Pharmacy kn-affil= affil-num=8 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= en-keyword=Environmental water kn-keyword=Environmental water en-keyword=Ion kn-keyword=Ion en-keyword=Prevalence kn-keyword=Prevalence en-keyword=Survival kn-keyword=Survival en-keyword=Vibrio cholerae kn-keyword=Vibrio cholerae END start-ver=1.4 cd-journal=joma no-vol=371 cd-vols= no-issue= article-no= start-page=fnae053 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=2024 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Regulatory role of VvsB protein on serine protease activity of VvsA in Vibrio vulnificus en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background:Vibrio vulnificus NCIMB2137, a Gram-negative, metalloprotease negative estuarine strain was isolated from a diseased eel. A 45 kDa chymotrypsin-like alkaline serine protease known as VvsA has been recently reported as one of the major virulence factor responsible for the pathogenesis of this strain. The vvsA gene along with a downstream gene vvsB, whose function is still unknown constitute an operon designated as vvsAB. Objective: This study examines the contribution of VvsB to the functionality of VvsA. Method: In this study, VvsB was individually expressed using Rapid Translation System (RTS system), followed by an analysis of its role in regulating the serine protease activity of VvsA. Result: The proteolytic activity of VvsA increased upon the addition of purified VvsB to the culture supernatant of V. vulnificus. However, the attempts of protein expression using an E. coli system revealed a noteworthy observation that protein expression from the vvsA gene exhibited higher protease activity compared to that from the vvsAB gene within the cytoplasmic fraction. These findings suggest an intricate interplay between VvsB and VvsA, where VvsB potentially interacts with VvsA inside the bacterium and suppress the proteolytic activity. While outside the bacterial milieu, VvsB appears to stimulate the activation of inactive VvsA. Conclusion: The findings suggest that Vibrio vulnificus regulates VvsA activity through the action of VvsB, both intracellularly and extracellularly, to ensure its survival. en-copyright= kn-copyright= en-aut-name=KawaseTomoka en-aut-sei=Kawase en-aut-mei=Tomoka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=DebnathAnusuya en-aut-sei=Debnath en-aut-mei=Anusuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Biotechnology, Brainware University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=RTS system kn-keyword=RTS system en-keyword=in vitro cell-free translation system, PU kn-keyword=in vitro cell-free translation system, PU en-keyword=Proteinase unit, VvsA kn-keyword=Proteinase unit, VvsA en-keyword=Vibrio vulnificus serine protease, SD kn-keyword=Vibrio vulnificus serine protease, SD en-keyword=Shine-Dalgarno sequence kn-keyword=Shine-Dalgarno sequence END start-ver=1.4 cd-journal=joma no-vol=23 cd-vols= no-issue=8 article-no= start-page=1509 end-page=1519 dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240710 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Intramolecular [ƒÎ4s?+?ƒÎ4s] photocycloaddition of carbon- and nitrogen-bridged [32](1,4)naphthalenophanes en-subtitle= kn-subtitle= en-abstract= kn-abstract=[32](1,4)Naphthalenophanes, bearing carbon-bridge chains (syn- and anti-NPs) and nitrogen-bridge chains (syn- and anti-ANPs), were synthesized, and their X-ray structures and photoreactions were investigated. The intramolecular separation distance between the naphthalene cores for ANPs was shorter than that for NPs, suggesting that intramolecular interactions between the naphthalene rings were more efficient for ANPs compared to NPs. Upon photoirradiation at 300 nm, anti-NP, syn-ANP and anti-ANP produced the corresponding intramolecular [ƒÎ4s?+?ƒÎ4s] cycloadducts, whereas syn-NP gave an unidentified complex product mixture. Quantum yields for the photo-consumption (ƒ³PC) of NPs and ANPs were evaluated to quantitatively compare their photoreactivity. The ƒ³PC values of ANPs were approximately two-fold higher than those of ANPs.Noteworthily, the ƒ³PC value of syn-ANP was estimated to be unity. Based on these results we discuss the effects of the alignments of the naphthalene cores (anti vs. syn) and the bridging elements (C-bridge vs. N-bridge) on the photoreaction efficiencies of [32](1,4)naphthalenophanes. en-copyright= kn-copyright= en-aut-name=OgumaYukiko en-aut-sei=Oguma en-aut-mei=Yukiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamotoMasanori en-aut-sei=Yamamoto en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SunatsukiYukinari en-aut-sei=Sunatsuki en-aut-mei=Yukinari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OtaHiromi en-aut-sei=Ota en-aut-mei=Hiromi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Department of Instrumental Analysis, Advanced Science Research Center, Okayama University kn-affil= affil-num=5 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=6 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Cyclophane kn-keyword=Cyclophane en-keyword=Azacyclophane kn-keyword=Azacyclophane en-keyword=Naphthalenophane kn-keyword=Naphthalenophane en-keyword=Photocycloaddition kn-keyword=Photocycloaddition en-keyword=[4 + 4] cycloaddition kn-keyword=[4 + 4] cycloaddition END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240516 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=The optimum quantity of debt for an aging Japan: welfare?and demographic dynamics en-subtitle= kn-subtitle= en-abstract= kn-abstract=Japanfs government is heavily indebted, and the current net debt tends to increase. This paper uses an extended life-cycle general equilibrium model with endogenous fertility to investigate an optimal size of government debt from two viewpoints: individual welfare and future demographic dynamics. A simulation analysis finds that the level of net government debt, which maximizes per-capita utility, is negative at???220% of Japanfs gross domestic product (GDP). The results also indicate that the net debt-to-GDP ratio of???220% produces a considerable per-capita welfare gain; however, compared to the baseline simulation with a debt-to-GDP ratio of 150%, it substantially decreases the total population in the long run. en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Faculty of Economics, Okayama University kn-affil= en-keyword=Government debt kn-keyword=Government debt en-keyword=Welfare kn-keyword=Welfare en-keyword=Demographic dynamics kn-keyword=Demographic dynamics en-keyword=Japanese economy kn-keyword=Japanese economy en-keyword=Simulation analysis kn-keyword=Simulation analysis en-keyword=H30 kn-keyword=H30 en-keyword=C68 kn-keyword=C68 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=—V—£N-ƒOƒŠƒJƒ“‚̶—‹@”\‰ðÍ‚ð–Ú“I‚Æ‚µ‚½ƒGƒ“ƒh-ƒÀ-N-ƒAƒZƒ`ƒ‹ƒOƒ‹ƒRƒTƒ~ƒjƒ_[ƒ[ (ENGase) Œ‡‘¹ƒgƒ}ƒg‚Ì\’z‚ÆA•¨ENGase‚Ì“œ“]ˆÚŠˆ«‚ÉŠÖ‚·‚錤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKAMOTONaoko en-aut-sei=OKAMOTO en-aut-mei=Naoko kn-aut-name=‰ª–{®Žq kn-aut-sei=‰ª–{ kn-aut-mei=®Žq aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Environmental and Life Science, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŠÂ‹«¶–½‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=õF‘Ì^ƒNƒƒ}ƒ`ƒ“‹ÃW‰òˆÚAF ƒ~ƒgƒRƒ“ƒhƒŠƒA‚ÌŽ‚¿ž‚Ý‚ðŬŒÀ‚É—}‚¦‚½ƒ~ƒgƒRƒ“ƒhƒŠƒA’uŠ·‚Ì‚½‚ß‚ÌV‹KƒAƒvƒ[ƒ`-ƒqƒgõF‘Ì‹ÃW‰òˆÚA‚ɑ΂·‚éƒ}ƒEƒXŽÀŒ±‚̈Ӗ¡‚·‚é‚à‚Ì kn-title=Aggregated chromosomes/chromatin transfer: a novel approach for mitochondrial replacement with minimal mitochondrial carryover: the implications of mouse experiments for human aggregated chromosome transfer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKAMOTORyota en-aut-sei=OKAMOTO en-aut-mei=Ryota kn-aut-name=‰ª–{—É‘¾ kn-aut-sei=‰ª–{ kn-aut-mei=—É‘¾ aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=452 cd-vols= no-issue= article-no= start-page=115613 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2024 dt-pub=20240701 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Photochemical synthesis and solvatochromic fluorescence behavior of imide-fused phenacenes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Chrysenes, picene, fulminene, modified with imide, bromo, and amino functionalities, were synthesized through Mallory photoreaction as the key step, and their electronic spectra were investigated. Fluorescence spectra of chrysene-diimide CHRDI and bromo-substituted phencanene-imides, BrCHRI, BrPICI, BrFULI were dependent on solvent polarity to display appreciable fluorescence color changes. The solvatofluorochromic behavior was analyzed by conventional relationships between Stokes shift and solvent polarity parameters, such as Lippert-Mataga and Bilot-Kawski equations. The results indicated that the solvatofluorochromism was derived from the intramolecular charge transfer (ICT) nature in the excited state. Theoretical studies using time-dependent density-functional theory revealed that the phenacene-imide molecules in the fluorescent state possessed ICT characters between the strongly electron-withdrawing imide moiety and moderately electron-donating phenacene cores. Amino-substituted chrysene-imide NH2CHRI showed fluorescence band in a red region (ƒÉFL = 618 nm) in toluene with a very large Stokes shift (ƒ¢ nu= 7630 cm?1) suggesting that the molecule in the fluorescent state was highly polarized. The present results indicate that phenacenes would provide potential platforms for constructing future functional fluorophores through an appropriate functionalization. en-copyright= kn-copyright= en-aut-name=NoseKeito en-aut-sei=Nose en-aut-mei=Keito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=3 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=4 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=5 en-affil=Graduate School of Environmental, Life, Natural Science and Technology, Okayama University kn-affil= en-keyword=Phenacene kn-keyword=Phenacene en-keyword=Imide kn-keyword=Imide en-keyword=Fluorescence kn-keyword=Fluorescence en-keyword=Solvatofluorochromism kn-keyword=Solvatofluorochromism en-keyword=Intramolecular charge transfer kn-keyword=Intramolecular charge transfer END start-ver=1.4 cd-journal=joma no-vol=135 cd-vols= no-issue=3 article-no= start-page=152 end-page=157 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20231201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A 4th step of visual art instruction in medical education kn-title=ˆãŠw‚É‚¨‚¯‚éuƒrƒWƒ…ƒAƒ‹ƒA[ƒg‹³ˆçv‚Ì“WŠJF‘æ‚SƒXƒeƒbƒv\ ˆãŠw‹³ˆç‚É•K—v‚Èg‹C‚«h‚ð—^‚¦‚éŽö‹Æ\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name=–،Ҍh—T kn-aut-sei=–ØŒÒ kn-aut-mei=Œh—T aut-affil-num=1 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name=¬”ä‰ê”üŽq kn-aut-sei=¬”ä‰ê kn-aut-mei=”üŽq aut-affil-num=2 ORCID= en-aut-name=KuboTakuya en-aut-sei=Kubo en-aut-mei=Takuya kn-aut-name=‹v•Û‘ì–ç kn-aut-sei=‹v•Û kn-aut-mei=‘ì–ç aut-affil-num=3 ORCID= en-aut-name=OtsukaMasumi en-aut-sei=Otsuka en-aut-mei=Masumi kn-aut-name=‘å’ˉv”ü kn-aut-sei=‘å’Ë kn-aut-mei=‰v”ü aut-affil-num=4 ORCID= en-aut-name=OkamotoYuko en-aut-sei=Okamoto en-aut-mei=Yuko kn-aut-name=‰ª–{—TŽq kn-aut-sei=‰ª–{ kn-aut-mei=—TŽq aut-affil-num=5 ORCID= en-aut-name=FukutomiKoh en-aut-sei=Fukutomi en-aut-mei=Koh kn-aut-name=•Ÿ•yK kn-aut-sei=•Ÿ•y kn-aut-mei=K aut-affil-num=6 ORCID= en-aut-name=MatsumotoHiroshi en-aut-sei=Matsumoto en-aut-mei=Hiroshi kn-aut-name=¼–{—m kn-aut-sei=¼–{ kn-aut-mei=—m aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@Œ`¬ÄŒšŠO‰È affil-num=2 en-affil=Department of General Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@‘‡“à‰ÈE‘‡f—Ã‰È affil-num=3 en-affil=Department of Emergency and Critical Care Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@‹~–½‹~‹}‰È affil-num=4 en-affil=OTSUKA DESIGN Co., Ltd. kn-affil=Š”Ž®‰ïŽÐ‘å’˃fƒUƒCƒ“ affil-num=5 en-affil=Okayama Prefectural Museum of Art kn-affil=‰ªŽRŒ§—§”üpŠÙ affil-num=6 en-affil=Okayama Prefectural Museum of Art kn-affil=‰ªŽRŒ§—§”üpŠÙ affil-num=7 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@Œ`¬ÄŒšŠO‰È END start-ver=1.4 cd-journal=joma no-vol=25 cd-vols= no-issue=45 article-no= start-page=31107 end-page=31117 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=2023 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Solvation free energies of alcohols in water: temperature and pressure dependences en-subtitle= kn-subtitle= en-abstract= kn-abstract=Solvation free energies ƒÊ* of amphiphilic species, methanol and 1,2-hexanediol, are obtained as a function of temperature or pressure based on molecular dynamics simulations combined with efficient free-energy calculation methods. In general, ƒÊ* of an amphiphile can be divided into Image ID:d3cp03799a-t1.gif and Image ID:d3cp03799a-t2.gif, the nonpolar and electrostatic contributions, and the former is further divided into Image ID:d3cp03799a-t3.gif and Image ID:d3cp03799a-t4.gif which are the work of cavity formation process and the free energy change due to weak, attractive interactions between the solute molecule and surrounding solvent molecules. We demonstrate that ƒÊ* of the two amphiphilic solutes can be obtained accurately using a perturbation combining method, which relies on the exact expressions for Image ID:d3cp03799a-t5.gif and Image ID:d3cp03799a-t6.gif and requires no simulations of intermediate systems between the solute with strong, repulsive interactions and the solute with the van der Waals and electrostatic interactions. The decomposition of ƒÊ* gives us several physical insights including that ƒÊ* is an increasing function of T due to Image ID:d3cp03799a-t7.gif, that the contributions of hydrophilic groups to the temperature dependence of ƒÊ* are additive, and that the contribution of the van der Waals attraction to the solvation volume is greater than that of the electrostatic interactions. en-copyright= kn-copyright= en-aut-name=TairaAoi en-aut-sei=Taira en-aut-mei=Aoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkamotoRyuichi en-aut-sei=Okamoto en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SumiTomonari en-aut-sei=Sumi en-aut-mei=Tomonari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Information Science, University of Hyogo kn-affil= affil-num=3 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230925 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Žq‹{“à–ŒŠà‚É‚¨‚¢‚Ä“]ˆÚ‘ƒ‚Ì•ªŽqŠw“I“Á’¥‚Í‚æ‚è—\Œã‚𔽉f‚·‚é kn-title=Molecular Characteristics of Metastatic Lesions Have Superior Prognositc Impact on Endometrial Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKAMOTOKazuhiro en-aut-sei=OKAMOTO en-aut-mei=Kazuhiro kn-aut-name=‰ª–{˜a_ kn-aut-sei=‰ª–{ kn-aut-mei=˜a_ aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=135 cd-vols= no-issue=2 article-no= start-page=85 end-page=88 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A third step of visual art instruction in medical education : Introduction of visual thinking strategies supported by Okayama Prefectural Museum of Art kn-title=ˆãŠw‚É‚¨‚¯‚éuƒrƒWƒ…ƒAƒ‹ƒA[ƒg‹³ˆçv‚Ì“WŠJF‘æ‚RƒXƒeƒbƒv\ ‰ªŽRŒ§—§”üpŠÙ‚Ì‹¦—Í‚É‚æ‚é‘ΘbŒ^ŠÓÜ‚Ì“±“ü\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KimataYoshihiro en-aut-sei=Kimata en-aut-mei=Yoshihiro kn-aut-name=–،Ҍh—T kn-aut-sei=–ØŒÒ kn-aut-mei=Œh—T aut-affil-num=1 ORCID= en-aut-name=ObikaMikako en-aut-sei=Obika en-aut-mei=Mikako kn-aut-name=¬”ä‰ê”üŽq kn-aut-sei=¬”ä‰ê kn-aut-mei=”üŽq aut-affil-num=2 ORCID= en-aut-name=KuboTakuya en-aut-sei=Kubo en-aut-mei=Takuya kn-aut-name=‹v•Û‘ì–ç kn-aut-sei=‹v•Û kn-aut-mei=‘ì–ç aut-affil-num=3 ORCID= en-aut-name=OtsukaMasumi en-aut-sei=Otsuka en-aut-mei=Masumi kn-aut-name=‘å’ˉv”ü kn-aut-sei=‘å’Ë kn-aut-mei=‰v”ü aut-affil-num=4 ORCID= en-aut-name=OkamotoYuko en-aut-sei=Okamoto en-aut-mei=Yuko kn-aut-name=‰ª–{—TŽq kn-aut-sei=‰ª–{ kn-aut-mei=—TŽq aut-affil-num=5 ORCID= en-aut-name=FukutomiKoh en-aut-sei=Fukutomi en-aut-mei=Koh kn-aut-name=•Ÿ•yK kn-aut-sei=•Ÿ•y kn-aut-mei=K aut-affil-num=6 ORCID= en-aut-name=MatsumotoHiroshi en-aut-sei=Matsumoto en-aut-mei=Hiroshi kn-aut-name=¼–{—m kn-aut-sei=¼–{ kn-aut-mei=—m aut-affil-num=7 ORCID= affil-num=1 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@Œ`¬ÄŒšŠO‰È affil-num=2 en-affil=Department of General Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@‘‡“à‰ÈE‘‡f—Ã‰È affil-num=3 en-affil=Department of Emergency and Critical Care Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@‹~–½‹~‹}‰È affil-num=4 en-affil=OTSUKA DESIGN Co., Ltd. kn-affil=Š”Ž®‰ïŽÐ‘å’˃fƒUƒCƒ“ affil-num=5 en-affil=Okayama Prefectural Museum of Art kn-affil=‰ªŽRŒ§—§”üpŠÙ affil-num=6 en-affil=Okayama Prefectural Museum of Art kn-affil=‰ªŽRŒ§—§”üpŠÙ affil-num=7 en-affil=Department of Plastic and Reconstructive Surgery, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@Œ`¬ÄŒšŠO‰È END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=8 article-no= start-page=1997 end-page=2005 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230608 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Study on joint characteristics in laser butt welding of AMed and wrought Ti6Al4V plates en-subtitle= kn-subtitle= en-abstract= kn-abstract=Titanium alloy Ti6Al4V has been widely applied to medical, automotive, and aerospace industries due to its excellent properties such as high strength and excellent corrosion resistance. On the other hand, additive manufacturing (AM) technology can give the freedom of design of the products. In order to spread the AMed products, the joining of AMed and wrought products are required, and it is important to understand the joint characteristics. In this study, butt welding of Ti6Al4V plate was conducted by fiber laser in argon shielding, and the joint characteristics of laser weld wrought/wrought, AMed/AMed, and AMed/wrought Ti6Al4V plates were experimentally investigated. The AMed plate has higher tensile strength than wrought plate but the elongation of AMed plate is smaller, since AMed plate has ƒ¿f martensite due to rapid cooling during laser irradiation in AM process. Then, the laser weld joint of AMed/AMed plates has higher tensile strength, but smaller elongation than that of wrought/wrought plates. The weld joint of AMed/wrought plates shows good welding state, since small heat input leads to formation of small weld bead with higher hardness between wrought and AMed plates. en-copyright= kn-copyright= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShinonagaTogo en-aut-sei=Shinonaga en-aut-mei=Togo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TakemotoYoshito en-aut-sei=Takemoto en-aut-mei=Yoshito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OchiAkihiro en-aut-sei=Ochi en-aut-mei=Akihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KishimotoRyuya en-aut-sei=Kishimoto en-aut-mei=Ryuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=PityanaSisa en-aut-sei=Pityana en-aut-mei=Sisa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ArthurNana en-aut-sei=Arthur en-aut-mei=Nana kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OmoniyiPeter en-aut-sei=Omoniyi en-aut-mei=Peter kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MahamoodRasheedat en-aut-sei=Mahamood en-aut-mei=Rasheedat kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=MainaMartin en-aut-sei=Maina en-aut-mei=Martin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=AkinlabiEsther en-aut-sei=Akinlabi en-aut-mei=Esther kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= affil-num=1 en-affil=Okayama University kn-affil= affil-num=2 en-affil=Okayama University kn-affil= affil-num=3 en-affil=Okayama University kn-affil= affil-num=4 en-affil=Okayama University kn-affil= affil-num=5 en-affil=Okayama University kn-affil= affil-num=6 en-affil=Okayama University kn-affil= affil-num=7 en-affil=National Laser Centre, CSIR kn-affil= affil-num=8 en-affil=National Laser Centre, CSIR kn-affil= affil-num=9 en-affil=University of Johannesburg kn-affil= affil-num=10 en-affil=University of Johannesburg kn-affil= affil-num=11 en-affil=Jomo Kenyatta University of Agriculture and Technology kn-affil= affil-num=12 en-affil=University of Johannesburg kn-affil= en-keyword=Ti6Al4V kn-keyword=Ti6Al4V en-keyword=Joint characteristics kn-keyword=Joint characteristics en-keyword=Laser welding kn-keyword=Laser welding en-keyword=Butt welding kn-keyword=Butt welding en-keyword=Additive manufacturing kn-keyword=Additive manufacturing END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230324 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Cardio-ankle vascular index‚É‚æ‚éSŒŒŠÇƒCƒxƒ“ƒg—\‘ª”\‚̉ü‘P kn-title=Cardio-ankle vascular index as an arterial stiffness marker improves the prediction of cardiovascular events in patients without cardiovascular diseases en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKAMOTOYuko en-aut-sei=OKAMOTO en-aut-mei=Yuko kn-aut-name=‰ª–{—CŽq kn-aut-sei=‰ª–{ kn-aut-mei=—CŽq aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=13 cd-vols= no-issue=6 article-no= start-page=4096 end-page=4101 dt-received= dt-revised= dt-accepted= dt-pub-year=2023 dt-pub=20230130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Solvent-dependent fluorescence behaviour of imide-fused [n]phenacenes (n=3, 5, 7) en-subtitle= kn-subtitle= en-abstract= kn-abstract=Imide-fused [n]phenacenes (nPDIs, n = 3, 5, 7) were systematically synthesised and their electronic features were investigated by electrochemical and electronic spectral measurements. nPDIs showed two reduction waves attributed to formation of radical ions and dianions. 3PDI produced blue fluorescence independent of solvent polarity. In contrast, 5PDI and 7PDI displayed marked positive solvatofluorochromism due to intramolecular charge transfer characters between the imide moieties and phenacene pi cores in the excited state. The spectral features were analyzed by the Lippert-Mataga relationship and theoretical calculations. en-copyright= kn-copyright= en-aut-name=NoseKeito en-aut-sei=Nose en-aut-mei=Keito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshiokaKaito en-aut-sei=Yoshioka en-aut-mei=Kaito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Division of Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=4 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=5 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=6 en-affil=Division of Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=22 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20221001 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Colonization with extended-spectrum beta-lactamase-producing Escherichia coli and traveler's diarrhea attack rates among travelers to India: a systematic review and meta-analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background India is an attractive destination for travelers. Unfortunately, numerous reports exist on traveler's diarrhea (TD) and fecal colonization with extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-EC) among international travelers visiting India. Here, we systematically reviewed studies published on the acquisition of ESBL-EC and TD attack rates among international visitors to India. Methods Design: Systematic review and meta-analysis. A systematic search was performed using Google Scholar, PubMed, EMBASE, Web of Science, and gray literature from 2000 to December 2021, for studies containing data for ESBL-EC acquisition or TD experience related to a trip to India. Random effects models were used to compute the prevalence of ESBL-EC acquisition and TD attack. Results The literature search yielded a total of 5023 records. Of these, 31 met our inclusion criteria for systematic review and only 17 could be meta-analyzed (9 for TD, and 8 for ESBL-EC). The overall pooled attack rate of TD was 39% (95% confidence interval, CI: 25-53%). In studies where travelers' memory was used to diagnose TD, the pooled attack rate of TD was slightly higher (42%, 95% CI: 21-64%) compared to those where TD was objectively documented (33%, 95% CI: 17-49%). There were significant risks to be colonized with ESBL-EC among the travelers who experienced TD. The pooled rate of ESBL-EC colonization was 72% (CI: 67-78%). Most ESBL-EC produced CTX-M-15 enzyme. Furthermore, most of the travelers who acquired ESBL-EC were from highly industrialized countries recruited from travel clinics: Canada (n = 80), Germany (n = 69), Netherlands (n = 20), Sweden (n = 18), Japan (n = 10), Finland (n = 8), USA (n = 7), Spain (n = 5), and Denmark (n = 3). Conclusions TD pooled attack rate and ESBL-EC acquisition among international travelers visiting India were high in this study. However, we cannot make generalizations based upon this TD pooled attack rate for the current situation, due to a lack of current data. Our study highlights that travelers should be advised on TD to ensure that they do not disregard the risk of contracting TD and be better prepared as a result. It also illustrates the importance of international travel in acquiring antibiotic-resistant Escherichia coli. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=ESBL-EC kn-keyword=ESBL-EC en-keyword=Traveler's diarrhea kn-keyword=Traveler's diarrhea en-keyword=International travelers kn-keyword=International travelers en-keyword=India kn-keyword=India en-keyword=Meta-analysis kn-keyword=Meta-analysis END start-ver=1.4 cd-journal=joma no-vol=11 cd-vols= no-issue=11 article-no= start-page=2095 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211113 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cholera Rapid Diagnostic Tests for the Detection of Vibrio cholerae O1: An Updated Meta-Analysis en-subtitle= kn-subtitle= en-abstract= kn-abstract=The rapid diagnosis of cholera contributes to adequate outbreak management. This meta-analysis assesses the diagnostic accuracy of cholera rapid tests (RDTs) to detect Vibrio cholerae O1. Methods: Systematic review and meta-analysis. We searched four databases (Medline, EMBASE, Google Scholar, and Web of Science up to 8 September 2021) for studies that evaluated cholera RDTs for the detection of V. cholerae O1 compared with either stool culture or polymerase chain reaction (PCR). We assessed the studies' quality using the QUADAS-2 criteria. In addition, in this update, GRADE approach was used to rate the overall certainty of the evidence. We performed a bivariate random-effects meta-analysis to calculate the pooled sensitivity and specificity of cholera RDTs. Results: Overall, 20 studies were included in this meta-analysis. Studies were from Africa (n = 11), Asia (n = 7), and America (Haiti; n = 2). They evaluated eight RDTs (Crystal VC-O1, Crystal VC, Cholkit, Institut Pasteur cholera dipstick, SD Bioline, Artron, Cholera Smart O1, and Smart II Cholera O1). Using direct specimen testing, sensitivity and specificity of RDTs were 90% (95% CI, 86 to 93) and 86% (95% CI, 81 to 90), respectively. Cholera Sensitivity was higher in studies conducted in Africa [92% (95% CI, 89 to 94)] compared with Asia [82% (95% CI, 77 to 87)]. However, specificity [83% (95% CI, 71 to 91)] was lower in Africa compared with Asia [90% (95% CI, 84 to 94)]. GRADE quality of evidence was estimated as moderate. Conclusions: Against culture or PCR, current cholera RDTs have moderate sensitivity and specificity for detecting Vibrio cholerae O1. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=DebnathAnusuya en-aut-sei=Debnath en-aut-mei=Anusuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=rapid test kn-keyword=rapid test en-keyword=cholera kn-keyword=cholera en-keyword=Vibrio cholera O1 kn-keyword=Vibrio cholera O1 en-keyword=sensitivity kn-keyword=sensitivity en-keyword=specificity kn-keyword=specificity en-keyword=accuracy kn-keyword=accuracy en-keyword=update kn-keyword=update END start-ver=1.4 cd-journal=joma no-vol=156 cd-vols= no-issue=22 article-no= start-page=221104 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220614 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Osmotic second virial coefficients for hydrophobic interactions as a function of solute size en-subtitle= kn-subtitle= en-abstract= kn-abstract=To gain quantitative insight into how the overall strength of the hydrophobic interaction varies with the molecular size, we calculate osmotic second virial coefficients B for hydrophobic spherical molecules of different diameters ƒÐ in water based on molecular simulation with corrections to the finite-size and finite-concentration effects. It is shown that B?(<0) changes by two orders of magnitude greater as ƒÐ increases twofold and its solute-size dependence is best fit by a power law B å ƒÐ ƒ¿ with the exponent ƒ¿ ? 6, which contrasts with the cubic power law that the second virial coefficients of gases obey. It is also found that values of B for the solutes in a nonpolar solvent are positive but they obey the same power law as in water. A thermodynamic identity for B derived earlier [K. Koga, V. Holten, and B. Widom, J. Phys. Chem. B 119, 13391 (2015)] indicates that if B is asymptotically proportional to a power of ƒÐ, the exponent ƒ¿ must be equal to or greater than 6. en-copyright= kn-copyright= en-aut-name=NaitoHidefumi en-aut-sei=Naito en-aut-mei=Hidefumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkamotoRyuichi en-aut-sei=Okamoto en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SumiTomonari en-aut-sei=Sumi en-aut-mei=Tomonari kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=2 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=3 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Chemistry, Faculty of Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=1.2ƒeƒXƒ‰ƒI[ƒvƒ“MRI‚ð—p‚¢‚½jƒA[ƒeƒBƒtƒ@ƒNƒg‚Ì“Á’¥‚¨‚æ‚ÑúŽh¸“x‚ÌŠî‘b“IŒŸ“¢@ kn-title=Needle artifact characteristics and insertion accuracy using a 1.2 T open MRI scanner: A phantom study en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoSoichiro en-aut-sei=Okamoto en-aut-mei=Soichiro kn-aut-name=‰ª–{‘ˆê˜Y kn-aut-sei=‰ª–{ kn-aut-mei=‘ˆê˜Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=19 cd-vols= no-issue=9 article-no= start-page=5738 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220508 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Cholera Outbreaks in India, 2011-2020: A Systematic Review en-subtitle= kn-subtitle= en-abstract= kn-abstract=Fecal contamination of water sources and open defecation have been linked to cholera outbreaks in India. However, a systematic review on the drivers responsible for these outbreaks has yet to be published. Here, we systematically review the published literature on cholera outbreaks in India between 2011 and 2020. We searched studies in English in three databases (MEDLINE, EMBASE, and Web of Science) and the Integrated Disease Surveillance Program that tracks cholera outbreaks throughout India. Two authors independently extracted data and assessed the quality of the included studies. Quantitative data on the modes of transmission reviewed in this study were assessed for any change over time between 2011-2015 and 2016-2020. Our search retrieved 10823 records initially, out of which 81 full-text studies were assessed for eligibility. Among these 81 studies, 20 were eligible for inclusion in this review. There were 565 reported outbreaks between 2011 and 2020 that led to 45,759 cases and 263 deaths. Outbreaks occurred throughout the year; however, they exploded with monsoons (June through September). In Tamil Nadu, a typical peak of cholera outbreaks was observed from December to January. Seventy-two percent (33,089/45,759) of outbreak-related cases were reported in five states, namely Maharashtra, West Bengal, Punjab, Karnataka, and Madhya Pradesh. Analysis of these outbreaks highlighted the main drivers of cholera including contaminated drinking water and food, inadequate sanitation and hygiene (including open defecation), and direct contact between households. The comparison between 2011-2015 and 2016-2020 showed a decreasing trend in the outbreaks that arose due to damaged water pipelines. Many Indians still struggle with open defecation, sanitation, and clean water access. These issues should be addressed critically. In addition, it is essential to interrupt cholera short-cycle transmission (mediated by households, stored drinking water and foodstuffs) during an outbreak. As cholera is associated with deprivation, socio-economic development is the only long-term solution. en-copyright= kn-copyright= en-aut-name=MuzemboBasilua Andre en-aut-sei=Muzembo en-aut-mei=Basilua Andre kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KitaharaKei en-aut-sei=Kitahara en-aut-mei=Kei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=DebnathAnusuya en-aut-sei=Debnath en-aut-mei=Anusuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhnoAyumu en-aut-sei=Ohno en-aut-mei=Ayumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= en-keyword=cholera kn-keyword=cholera en-keyword=outbreak kn-keyword=outbreak en-keyword=water supply kn-keyword=water supply en-keyword=open defecation kn-keyword=open defecation en-keyword=sewage kn-keyword=sewage en-keyword=household kn-keyword=household en-keyword=food kn-keyword=food en-keyword=close contact kn-keyword=close contact en-keyword=behavioral changes kn-keyword=behavioral changes en-keyword=India kn-keyword=India END start-ver=1.4 cd-journal=joma no-vol=4 cd-vols= no-issue=2 article-no= start-page=025301 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220317 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=High-quality micro-shape fabrication of monocrystalline diamond by nanosecond pulsed laser and acid cleaning en-subtitle= kn-subtitle= en-abstract= kn-abstract=The flat plane of small surface roughness below 0.1 mu m average roughness was obtained for monocrystalline diamond by nanosecond pulsed laser irradiation of 1060 nm and post-process acid cleaning, at a laser fluence around the material removal threshold value. The glossy and flat plane at the bottom of the micro-groove was parallel to the top surface of the specimen, although the round beam of Gaussian mode was irradiated in the direction perpendicular to the top surface of specimen. The square beam of top-hat mode produced a shallower micro-groove with a wider, flatter bottom compared with the round beam in Gaussian mode. The creation method of the flat plane with small surface roughness was discussed in the arrangement strategy of linear micro-grooving by the square beam of top-hat mode. Normal side-by-side repetition of linear micro-grooving did not create a flat plane with constant depth. Therefore, a two-step scanning method was proposed in order to overcome the problem in the normal side-by-side repetition of liner micro-grooving. Non-removal areas were partly retained between the processing lines in the first step, and the laser scanning was conducted on the retained area in the second step. The newly proposed two-step scanning method was practical and useful to create a widely flat plane with small surface roughness, and the two-step scanning method provided superior control over the micro-groove depth. This proposed method can reduce the surface roughness in addition to the shape creation of monocrystalline diamond, and it can be used as a high-quality micro-shape fabrication method of monocrystalline diamond. en-copyright= kn-copyright= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkuboTubasa en-aut-sei=Okubo en-aut-mei=Tubasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KajitaniAtsuya en-aut-sei=Kajitani en-aut-mei=Atsuya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=monocrystalline diamond kn-keyword=monocrystalline diamond en-keyword=nanosecond pulsed laser kn-keyword=nanosecond pulsed laser en-keyword=flat surface kn-keyword=flat surface en-keyword=smooth surface kn-keyword=smooth surface en-keyword=micro-grooving kn-keyword=micro-grooving END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=6 article-no= start-page=5495 end-page=5501 dt-received= dt-revised= dt-accepted= dt-pub-year=2022 dt-pub=20220131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Evaluation of Effective Field-Effect Mobility in Thin-Film and Single-Crystal Transistors for Revisiting Various Phenacene-Type Molecules en-subtitle= kn-subtitle= en-abstract= kn-abstract=The magnitude of the field-effect mobility mu of organic thin-film and single-crystal field-effect transistors (FETs) has been over-estimated in certain recent studies. These reports set alarm bells ringing in the research field of organic electronics. Herein, we report a precise evaluation of the mu values using the effective field-effect mobility, mu(eff), a new indicator that is recently designed to prevent the FET performance of thin-film and single-crystal FETs based on various phenacene molecules from being overestimated. The transfer curves of a range of FETs based on phenacene are carefully categorized on the basis of a previous report. The exact evaluation of the value of mu(eff) depends on the exact classification of each transfer curve. The transfer curves of all our phenacene FETs could be successfully classified based on the method indicated in the aforementioned report, which made it possible to evaluate the exact value of mu(eff) for each FET. The FET performance based on the values of mu(eff) obtained in this study is discussed in detail. In particular, the mu(eff) values of single-crystal FETs are almost consistent with the mu values that were reported previously, but the mu(eff) values of thin-film FETs were much lower than those previously reported for mu, owing to a high absolute threshold voltage, vertical bar V-th vertical bar. The increase in the field-effect mobility as a function of the number of benzene rings, which was previously demonstrated based on the mu values of single-crystal FETs with phenacene molecules, is well reproduced from the mu(eff) values. The FET performance is discussed based on the newly evaluated mu(eff) values, and the future prospects of using phenacene molecules in FET devices are demonstrated. en-copyright= kn-copyright= en-aut-name=ZhangYanting en-aut-sei=Zhang en-aut-mei=Yanting kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=EguchiRitsuko en-aut-sei=Eguchi en-aut-mei=Ritsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamaoShino en-aut-sei=Hamao en-aut-mei=Shino kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GotoHidenori en-aut-sei=Goto en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=2 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Department of Chemistry, Okayama University kn-affil= affil-num=5 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=6 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=46 article-no= start-page=12820 end-page=12831 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20211110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Theory of Gas Solubility and Hydrophobic Interaction in Aqueous Electrolyte Solutions en-subtitle= kn-subtitle= en-abstract= kn-abstract=Ion-specific effects on the solubility of nonpolar solutes and on the solute?solute hydrophobic interaction in aqueous electrolyte solutions are studied on the basis of a continuum theory that incorporates the excluded volume of the molecules using the four-component (water, cations, anions, and solutes) Boubl??k?Mansoori?Carnahan?Starling?Leland model and ion hydration (electrostriction) using the Born model. We examine how the ordering of ions in the salt effect on the solubility as measured by the Sechenov coefficient KS changes with varying sizes of ions and solutes. Our calculation reproduces the general trend of experimentally measured KS and also provides insight into the irregular behavior of KS for lithium ion. The correlation between KS and the salt effect on the hydrophobic interaction that has been pointed out earlier is accounted for by an explicit connection between KS and the salt-enhanced-association coefficient CI in the expansion of the second osmotic virial coefficient B(ns) = B(0) ? CIns + ??? in powers of the salt density ns at fixed pressure and temperature. The quadratic relation is derived for ions and solutes that are not very large. en-copyright= kn-copyright= en-aut-name=OkamotoRyuichi en-aut-sei=Okamoto en-aut-mei=Ryuichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=KogaKenichiro en-aut-sei=Koga en-aut-mei=Kenichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= affil-num=1 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=2 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210924 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ˆÝ‘BŽîF’·ŠúŠÔ‚ÌŒo‰ßŠÏŽ@’†‚É‚—¦‚ÉŠà‚Ì”­¶AˆÙŽž«ˆÝŠà”­¶‚̃ŠƒXƒN‚𔺂¤ kn-title=Gastric Adenoma: A High Incidence Rate of Developing Carcinoma and Risk of Metachronous Gastric Cancer according to Long-Term Follow-Up en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoYuki en-aut-sei=Okamoto en-aut-mei=Yuki kn-aut-name=‰ª–{—Y‹M kn-aut-sei=‰ª–{ kn-aut-mei=—Y‹M aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=16 cd-vols= no-issue=2 article-no= start-page=109 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=202110 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Formation and Its Mechanism of High-speed Micro-grooving on Metal Surface by Angled CW Laser Irradiation en-subtitle= kn-subtitle= en-abstract= kn-abstract=In general, pulsed lasers with high peak power have been used for the micro-groove formation. However, the processing speed is limited by the pulse repetition rate. On the other hand, CW laser can be expected to perform the high-speed processing by continuous energy input. The mechanism of micro-groove formation by CW laser was investigated by high-speed observation and the thermal fluid analysis. In the perpendicular irradiation of CW laser, the molten metal flows symmetrically around the keyhole to the backward direction, and micro-grooves remain at both edges of molten region. In contrast, in the angled irradiation, the molten metal at the reflection-side scatters as spatters. The remained molten metal flows from the reflection-side to the incident-side through the bottom of keyhole, since the recoil pressure is generated from the reflection-side to the incident-side. In addition, high-speed scanning contributes to keeping the sufficient time and force to move the molten metal in the backward direction. Then, the micro-groove remains at the reflection-side, while the upheaval is formed at the incident-side by gathering the molten metal from the reflection-side and the front of keyhole. Asymmetrical behavior of molten metal flow in angled irradiation of CW laser can create micro-groove in the reflection-side. en-copyright= kn-copyright= en-aut-name=TauraNozomi en-aut-sei=Taura en-aut-mei=Nozomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=MitsunobuAkiya en-aut-sei=Mitsunobu en-aut-mei=Akiya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SakaiTatsuhiko en-aut-sei=Sakai en-aut-mei=Tatsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University, Japan kn-affil= affil-num=2 en-affil=Faculty of Engineering, Okayama University, Japan kn-affil= affil-num=3 en-affil=NIPPON STEEL CORPORATION, Japan kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University, Japan kn-affil= affil-num=5 en-affil=Graduate School of Natural Science and Technology, Okayama University, Japan kn-affil= en-keyword=CW laser kn-keyword=CW laser en-keyword=micro-groove kn-keyword=micro-groove en-keyword=high-speed scanning kn-keyword=high-speed scanning en-keyword=thermal fluid analysis kn-keyword=thermal fluid analysis en-keyword=high-speed observation kn-keyword=high-speed observation END start-ver=1.4 cd-journal=joma no-vol=299 cd-vols= no-issue= article-no= start-page=117388 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effects of Superposition of 532?nm and 1064?nm Wavelengths in Copper Micro-welding by Pulsed Nd:YAG Laser en-subtitle= kn-subtitle= en-abstract= kn-abstract=Unstable and low absorption of laser energy is experienced in copper welding at around 1000?nm wavelength. At 532?nm wavelength, there is stable and high laser absorption by copper. Past researches have shown that transitional processing condition between keyhole and heat conduction welding results in a stable micro-welding process characterized by good surface quality and deep penetration. In order to adapt laser welding to copper using pulsed Nd:YAG lasers, investigations of welding quality and efficiency were addressed. Processing was done under transitional processing condition between heat conduction and keyhole welding. Copper C1020 specimens were processed using superposed laser wavelengths of 1064?nm and 532?nm. Effects of irradiation delay and power density on the process were clarified by taking measurements of absorption rates and molten volumes, and by analyzing the weld beads. In addition, the dynamics of molten area and keyhole formation were investigated through three-dimensional FEM analysis. A stabilized laser absorption and increased molten volume was achieved by superposition using 532?nm laser of an appropriate high power density coupled with a short irradiation delay for the 1064?nm laser, which resulted in high-efficiency welding of copper. en-copyright= kn-copyright= en-aut-name=MainaMartin Ruthandi en-aut-sei=Maina en-aut-mei=Martin Ruthandi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamadaKazuki en-aut-sei=Hamada en-aut-mei=Kazuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakashibaShin-ichi en-aut-sei=Nakashiba en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NishiNorio en-aut-sei=Nishi en-aut-mei=Norio kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil=Nontraditional Machining Laboratory, Okayama University kn-affil= affil-num=2 en-affil=Nontraditional Machining Laboratory, Okayama University kn-affil= affil-num=3 en-affil=Nontraditional Machining Laboratory, Okayama University kn-affil= affil-num=4 en-affil=Nontraditional Machining Laboratory, Okayama University kn-affil= affil-num=5 en-affil=Kataoka Corporation kn-affil= affil-num=6 en-affil=Kataoka Corporation kn-affil= END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue= article-no= start-page=726273 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210820 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Virulence of Cholera Toxin Gene-Positive Vibrio cholerae Non-O1/non-O139 Strains Isolated From Environmental Water in Kolkata, India en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cholera toxin (CT)-producing Vibrio cholerae O1 and O139 cause acute diarrheal disease and are proven etiological agents of cholera epidemics and pandemics. On the other hand, V. cholerae non-O1/non-O139 are designated as non-agglutinable (NAG) vibrios and are not associated with epidemic cholera. The majority of NAG vibrios do not possess the gene for CT (ctx). In this study, we isolated three NAG strains (strains No. 1, 2, and 3) with ctx from pond water in Kolkata, India, and examined their pathogenic properties. The enterotoxicity of the three NAG strains in vivo was examined using the rabbit ileal intestinal loop test. Strain No. 1 induced the accumulation of fluid in the loop, and the volume of fluid was reduced by simultaneous administration of anti-CT antiserum into the loop. The volume of fluid in the loop caused by strains No. 2 and 3 was small and undetectable, respectively. Then, we cultured these three strains in liquid medium in vitro at two temperatures, 25 degrees C and 37 degrees C, and examined the amount of CT accumulated in the culture supernatant. CT was accumulated in the culture supernatant of strain No.1 when the strain was cultured at 25 degrees C, but that was low when cultured at 37 degrees C. The CT amount accumulated in the culture supernatants of the No. 2 and No. 3 strains was extremely low at both temperature under culture conditions examined. In order to clarify the virulence properties of these strains, genome sequences of the three strains were analyzed. The analysis showed that there was no noticeable difference among three isolates both in the genes for virulence factors and regulatory genes of ctx. However, vibrio seventh pandemic island-II (VSP-II) was retained in strain No. 1, but not in strains No. 2 or 3. Furthermore, it was revealed that the genotype of the B subunit of CT in strain No. 1 was type 1 and those of strains No. 2 and 3 were type 8. Histopathological examination showed the disappearance of villi in intestinal tissue exposed to strain No. 1. In addition, fluid accumulated in the loop due to the action of strain No. 1 had hemolytic activity. This indicated that strain No. 1 may possesses virulence factors to induce severe syndrome when the strain infects humans, and that some strains of NAG vibrio inhabiting pond water in Kolkata have already acquired virulence, which can cause illness in humans. There is a possibility that these virulent NAG vibrios, which have acquired genes encoding factors involved in virulence of V. cholerae O1, may emerge in various parts of the world and cause epidemics in the future. en-copyright= kn-copyright= en-aut-name=TakahashiEizo en-aut-sei=Takahashi en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OchiSadayuki en-aut-sei=Ochi en-aut-mei=Sadayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MizunoTamaki en-aut-sei=Mizuno en-aut-mei=Tamaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MoritaDaichi en-aut-sei=Morita en-aut-mei=Daichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MoritaMasatomo en-aut-sei=Morita en-aut-mei=Masatomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OhnishiMakoto en-aut-sei=Ohnishi en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=KoleyHemanta en-aut-sei=Koley en-aut-mei=Hemanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=DuttaMoumita en-aut-sei=Dutta en-aut-mei=Moumita kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ChowdhuryGoutam en-aut-sei=Chowdhury en-aut-mei=Goutam kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=MukhopadhyayAsish K. en-aut-sei=Mukhopadhyay en-aut-mei=Asish K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=DuttaShanta en-aut-sei=Dutta en-aut-mei=Shanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MiyoshiShin-Ichi en-aut-sei=Miyoshi en-aut-mei=Shin-Ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=2 en-affil=Department of Health Pharmacy, Yokohama University of Pharmacy kn-affil= affil-num=3 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= affil-num=4 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=5 en-affil=Department of Bacteriology I, National Institute of Infectious Diseases kn-affil= affil-num=6 en-affil=Department of Bacteriology I, National Institute of Infectious Diseases kn-affil= affil-num=7 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=8 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=9 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=10 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=11 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=12 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= affil-num=13 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= en-keyword=Vibrio cholerae kn-keyword=Vibrio cholerae en-keyword=NAG Vibrio kn-keyword=NAG Vibrio en-keyword=cholera toxin kn-keyword=cholera toxin en-keyword=virulence kn-keyword=virulence en-keyword=environmental water kn-keyword=environmental water en-keyword=gene analysis kn-keyword=gene analysis END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue= article-no= start-page=1 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2021 dt-pub=20210325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=John Toland and the Invention of Pantheism: A Successor of Giordano Brunofs Philosophy kn-title=ƒWƒ‡ƒ“Eƒg[ƒ‰ƒ“ƒh‚É‚æ‚é”Ä_˜_‚Ì”­–¾ : ƒWƒ‡ƒ‹ƒ_[ƒmEƒuƒ‹[ƒm‚Ì“NŠw‚ÌŒp³ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OKAMOTOGenta en-aut-sei=OKAMOTO en-aut-mei=Genta kn-aut-name=‰ª–{Œ¹‘¾ kn-aut-sei=‰ª–{ kn-aut-mei=Œ¹‘¾ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ŽÐ‰ï•¶‰»‰ÈŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=102 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=2020 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Alpha-pinene and dizocilpine (MK-801) attenuate kindling development and astrocytosis in an experimental mouse model of epilepsy en-subtitle= kn-subtitle= en-abstract= kn-abstract=Understanding the molecular and cellular mechanisms involved during the onset of epilepsy is crucial for elucidating the overall mechanism of epileptogenesis and therapeutic strategies. Previous studies, using a pentylenetetrazole (PTZ)-induced kindling mouse model, showed that astrocyte activation and an increase in perineuronal nets (PNNs) and extracellular matrix (ECM) molecules occurred within the hippocampus. However, the mechanisms of initiation and suppression of these changes, remain unclear.
Herein, we analyzed the attenuation of astrocyte activation caused by dizocilpine (MK-801) administration, as well as the anticonvulsant effect of ƒ¿-pinene on seizures and production of ECM molecules. Our results showed that MK-801 significantly reduced kindling acquisition, while ƒ¿-pinene treatment prevented an increase in seizures incidences. Both MK-801 and ƒ¿-pinene administration attenuated astrocyte activation by PTZ and significantly attenuated the increase in ECM molecules.
Our results indicate that astrocyte activation and an increase in ECM may contribute to epileptogenesis and suggest that MK-801 and ƒ¿-pinene may prevent epileptic seizures by suppressing astrocyte activation and ECM molecule production. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimadaAtsumi en-aut-sei=Shimada en-aut-mei=Atsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MurakamiShinji en-aut-sei=Murakami en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KitamuraNaoya en-aut-sei=Kitamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WaniKenta en-aut-sei=Wani en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakahashiYu en-aut-sei=Takahashi en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IshiharaTakeshi en-aut-sei=Ishihara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare kn-affil= affil-num=2 en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College kn-affil= affil-num=3 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=7 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=8 en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= en-keyword=Epilepsy kn-keyword=Epilepsy en-keyword=Kindling kn-keyword=Kindling en-keyword=Pentylenetetrazol kn-keyword=Pentylenetetrazol en-keyword=Perineuronal nets kn-keyword=Perineuronal nets en-keyword=Wisteria floribunda kn-keyword=Wisteria floribunda END start-ver=1.4 cd-journal=joma no-vol=10 cd-vols= no-issue=52 article-no= start-page=31547 end-page=31552 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200826 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Facile synthesis of picenes incorporating imide moieties at both edges of the molecule and their application to n-channel field-effect transistors en-subtitle= kn-subtitle= en-abstract= kn-abstract=Picene derivatives incorporating imide moieties along the long-axis direction of the picene core (Cn-PicDIs) were conveniently synthesized through a four-step synthesis. Photochemical cyclization of dinaphthylethenes was used as the key step for constructing the picene skeleton. Field-effect transistor (FET) devices of Cn-PicDIs were fabricated by using ZrO2 as a gate substrate and their FET characteristics were investigated. The FET devices showed normally-off n-channel operation; the averaged electron mobility (ƒÊ) was evaluated to be 2(1) ~ 10?4, 1.0(6) ~ 10?1 and 1.4(3) ~ 10?2 cm2 V?1 s?1 for C4-PicDI, C8-PicDI and C12-PicDI, respectively. The maximum ƒÊ value as high as 2.0 ~ 10?1 cm2 V?1 s?1 was observed for C8-PicDI. The electronic spectra of Cn-PicDIs in solution showed the same profiles irrespective of the alkyl chain lengths. In contrast, in thin films, the UV absorption and photoelectron yield spectroscopy (PYS) indicated that the lowest unoccupied molecular orbital (LUMO) level of Cn-PicDIs gradually lowered upon the elongation of the alkyl chains, suggesting that the alkyl chains modify intermolecular interactions between the Cn-PicDI molecules in thin films. The present results provide a new strategy for constructing a high performance n-channel organic semiconductor material by utilizing the electronic features of phenacenes. en-copyright= kn-copyright= en-aut-name=GuoYuxin en-aut-sei=Guo en-aut-mei=Yuxin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YoshiokaKaito en-aut-sei=Yoshioka en-aut-mei=Kaito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HamaoShino en-aut-sei=Hamao en-aut-mei=Shino kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=5 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=6 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=7 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=8 article-no= start-page=1288 end-page=1291 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=202008 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Low Viability of Cholera Toxin-Producing Vibrio cholerae O1 in the Artificial Low Ionic Strength Aquatic Solution en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has been well known that Vibrio cholerae inhabit in environmental water. As many patients infected with cholera toxin-producing V. cholerae O1 (toxigenic V. cholerae O1) emerge in Kolkata, India, it has been thought that toxigenic V. cholerae O1 is easily detected in environmental water in Kolkata. However, we could not isolate toxigenic V. cholerae O1 from environmental water in Kolkata, though NAG Vibrio (generic name of V. cholerae non-O1/non-O139) is constantly detected. To clear the reason for the non-isolation of toxigenic V. cholerae O1, we examined the viability of V. cholera O1 and NAG Vibrios in the artificial low ionic strength aquatic solution. We found that the viability of toxigenic V. cholerae O1 in the solution is low, but that of NAG Vibrios is high. Subsequently, we examined the viability of NAG Vibrios possessing cholera toxin gene (ctx) in the same condition and found that the viability of these NAG Vibrios is low. These results indicate that the existence of ctx in V. cholerae affects the viability of V. cholerae in the aquatic solution used in this experiment. We thought that there was closely relation between the low viability of toxigenic V. cholerae O1 in the artificial low ionic strength aquatic solution and the low frequency of isolation of the strain from environmental water. en-copyright= kn-copyright= en-aut-name=PaulSubha Sankar en-aut-sei=Paul en-aut-mei=Subha Sankar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiEizo en-aut-sei=Takahashi en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=ChowdhuryGoutam en-aut-sei=Chowdhury en-aut-mei=Goutam kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MizunoTamaki en-aut-sei=Mizuno en-aut-mei=Tamaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MukhopadhyayAsish K. en-aut-sei=Mukhopadhyay en-aut-mei=Asish K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=DuttaShanta en-aut-sei=Dutta en-aut-mei=Shanta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= affil-num=2 en-affil=Department of Health Pharmacy, Yokohama University of Pharmacy kn-affil= affil-num=3 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=4 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences of Okayama University kn-affil= affil-num=6 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=7 en-affil=National Institute of Cholera and Enteric Diseases kn-affil= affil-num=8 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India kn-affil= en-keyword=Vibrio cholerae kn-keyword=Vibrio cholerae en-keyword=cholera toxin kn-keyword=cholera toxin en-keyword=aquatic solution kn-keyword=aquatic solution en-keyword=viability kn-keyword=viability END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=6 article-no= start-page=937 end-page=947 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200313 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Effect of numerical aperture on molten area characteristics in micro-joining of glass by picosecond pulsed laser en-subtitle= kn-subtitle= en-abstract= kn-abstract=Glass products with precise and sophisticated shapes are highly demanded in the field of MEMS due to their excellent properties. Ultrashort pulsed laser has been expected to be a powerful and reliable tool for micro-welding of glass. Focusing condition such as numerical aperture (N.A.) is a critical parameter that controls how ultrashort laser pulses interact with and propagate in glass, and it has a great influence on the laser micro-welding characteristics of glass. In order to investigate the quality of welding process, it is important to understand the dependence of the mechanical strength of molten area created in glass specimen with various numerical apertures. Therefore, the mechanical strength of molten area with various numerical apertures was evaluated in micro-welding of glass by picosecond pulsed laser. Higher bending strength could be obtained under an appropriate volume ratio of molten area and glass specimen, when continuous molten areas were formed. In addition, high density and large size of molten area without crack led to higher breaking stress. It is concluded that superior focusing characteristics such as N.A. 0.65 enable a long region of high power density in beam axis, which can satisfy both high mechanical strength and high processing speed. en-copyright= kn-copyright= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OuyangZhiyong en-aut-sei=Ouyang en-aut-mei=Zhiyong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=FujiwaraTakumi en-aut-sei=Fujiwara en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Picosecond pulsed laser kn-keyword=Picosecond pulsed laser en-keyword=Glass material kn-keyword=Glass material en-keyword=Numerical aperture kn-keyword=Numerical aperture en-keyword=Bending strength kn-keyword=Bending strength en-keyword=Breaking stress kn-keyword=Breaking stress END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=22 article-no= start-page=7422 end-page=7435 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200418 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of [7]phenacene incorporating tetradecyl chains in the axis positions and its application in field-effect transistors en-subtitle= kn-subtitle= en-abstract= kn-abstract=Field-effect transistors (FETs) were fabricated using a new type of phenacene molecule, 3,12-ditetradecyl[7]phenacene ((C14H29)2-[7]phenacene), and solid gate dielectrics or an electric double layer (EDL) capacitor with an ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate (bmim[PF6])). The new molecule, (C14H29)2-[7]phenacene, was efficiently synthesized via the Mallory photoreaction. Its crystal structure and electronic properties were determined, using X-ray diffraction, scanning tunneling microscopy/spectroscopy (STM and STS), absorption spectroscopy, and photoelectron yield spectroscopy, which showed a monoclinic crystal lattice (space group P21 (no. 4)) and an energy gap of ?3.0 eV. The STM image clearly showed the molecular structure of (C14H29)2-[7]phenacene, as well as the closed molecular stacking, indicative of a strong fastener effect between alkyl chains. The X-ray diffraction pattern of thin films of (C14H29)2-[7]phenacene formed on a SiO2/Si substrate suggested that the molecule stood on the surface with an inclined angle of 30‹ with respect to the normal axis of the surface. The FET properties were recorded in two-terminal measurement mode, showing p-channel normally-off characteristics. The averaged values of field-effect mobility, ƒÊ, were 1.6(3) cm2 V?1 s?1 for a (C14H29)2-[7]phenacene thin-film FET with a SiO2 gate dielectric and 6(4) ~ 10?1 cm2 V?1 s?1 for a (C14H29)2-[7]phenacene thin-film EDL FET with bmim[PF6]. Thus, higher FET performance was obtained with an FET using a thin film of (C14H29)2-[7]phenacene compared to parent [7]phenacene. This study could pioneer an avenue for the realization of high-performance FETs through the addition of alkyl chains to phenacene molecules. en-copyright= kn-copyright= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HamaoShino en-aut-sei=Hamao en-aut-mei=Shino kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KozasaKeiko en-aut-sei=Kozasa en-aut-mei=Keiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=WangYanan en-aut-sei=Wang en-aut-mei=Yanan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=PanYong-He en-aut-sei=Pan en-aut-mei=Yong-He kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YenYu-Hsiang en-aut-sei=Yen en-aut-mei=Yu-Hsiang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HoffmannGermar en-aut-sei=Hoffmann en-aut-mei=Germar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TaniFumito en-aut-sei=Tani en-aut-mei=Fumito kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=GotoKenta en-aut-sei=Goto en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=5 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=6 en-affil=Department of Physics & Center for Quantum Technology, National Tsing Hua University kn-affil= affil-num=7 en-affil=Department of Physics & Center for Quantum Technology, National Tsing Hua University kn-affil= affil-num=8 en-affil=Department of Physics & Center for Quantum Technology, National Tsing Hua University kn-affil= affil-num=9 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= affil-num=10 en-affil=Institute for Materials Chemistry and Engineering, Kyushu University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=6 article-no= start-page=435 end-page=444 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200328 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Genomic characterization of antibiotic resistance]encoding genes in clinical isolates of Vibrio cholerae non]O1/non]O139 strains from Kolkata, India: generation of novel types of genomic islands containing plural antibiotic resistance genes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Non]O1/non]O139 nontoxigenic Vibrio cholerae associated with cholera]like diarrhea has been reported in Kolkata, India. However, the property involved in the pathogenicity of these strains has remained unclear. The character of 25 non]O1/non]O139 nontoxigenic V. cholerae isolated during 8 years from 2007 to 2014 in Kolkata was examined. Determination of the serogroup showed that the serogroups O6, O10, O35, O36, O39, and O70 were represented by two strains in each serogroup, and the remaining isolates belonged to different serogroups. To clarify the character of antibiotic resistance of these isolates, an antibiotic resistance test and the gene analysis were performed. According to antimicrobial drug susceptibility testing, 13 strains were classified as drug resistant. Among them, 10 strains were quinolone resistant and 6 of the 13 strains were resistant to more than three antibiotics. To define the genetic background of the antibiotic character of these strains, whole]genome sequences of these strains were determined. From the analysis of these sequences, it becomes clear that all quinolone resistance isolates have mutations in quinolone resistance]determining regions. Further research on the genome sequence showed that four strains possess Class 1 integrons in their genomes, and that three of the four integrons are found to be located in their genomic islands. These genomic islands are novel types. This indicates that various integrons containing drug resistance genes are spreading among V. cholerae non]O1/non]O139 strains through the action of newly generated genomic islands. en-copyright= kn-copyright= en-aut-name=MoritaDaichi en-aut-sei=Morita en-aut-mei=Daichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiEizo en-aut-sei=Takahashi en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MoritaMasatomo en-aut-sei=Morita en-aut-mei=Masatomo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OhnishiMakoto en-aut-sei=Ohnishi en-aut-mei=Makoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MizunoTamaki en-aut-sei=Mizuno en-aut-mei=Tamaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=Miyoshi Shin]ichi en-aut-sei=Miyoshi en-aut-mei= Shin]ichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=DuttaDevarati en-aut-sei=Dutta en-aut-mei=Devarati kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=RamamurthyThandavarayan en-aut-sei=Ramamurthy en-aut-mei=Thandavarayan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=ChowdhuryGoutam en-aut-sei=Chowdhury en-aut-mei=Goutam kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=Mukhopadhyay Asish K. en-aut-sei=Mukhopadhyay en-aut-mei= Asish K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India, Okayama University kn-affil= affil-num=2 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India, Okayama University kn-affil= affil-num=3 en-affil=Department of Bacteriology I, National Institute of Infectious Diseases kn-affil= affil-num=4 en-affil=Department of Bacteriology I, National Institute of Infectious Diseases kn-affil= affil-num=5 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=6 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases kn-affil= affil-num=8 en-affil=Center for Human Microbial Ecology, Translational Health Science and Technology Institute kn-affil= affil-num=9 en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases kn-affil= affil-num=10 en-affil=Division of Bacteriology, National Institute of Cholera and Enteric Diseases kn-affil= affil-num=11 en-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India, Okayama University kn-affil= en-keyword=antibiotic resistance kn-keyword=antibiotic resistance en-keyword=diarrhea kn-keyword=diarrhea en-keyword=genome sequence kn-keyword=genome sequence en-keyword=genomic island kn-keyword=genomic island en-keyword=integron kn-keyword=integron en-keyword=Vibrio cholerae kn-keyword=Vibrio cholerae END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒRƒ‰[ƒQƒ“Œ‹‡Œ^‰–Šî«üˆÛ‰è×–E‘BˆöŽq‚Í‚»‚Ì‚‚¢‘gD“à‘Ø—¯«‚É‚æ‚Á‚ÄŒø—¦“I‚ÉŽ•Žü‘gDĶ‚ð‘£i‚·‚é en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoKentaro en-aut-sei=Okamoto en-aut-mei=Kentaro kn-aut-name=‰ª–{Œ›‘¾˜Y kn-aut-sei=‰ª–{ kn-aut-mei=Œ›‘¾˜Y aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=51 cd-vols= no-issue=2-3 article-no= start-page=123 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=2020 dt-pub=20200319 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Silver Democracy and Electoral System : Political Feasibility of Policy Reform Plans in an Aging Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Humanities and Social Sciences, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=5817 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201949 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Helping-Like Behaviour in Mice Towards Conspecifics Constrained Inside Tubes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Prosocial behaviour, including helping behaviour, benefits others. Recently, helping-like behaviour has been observed in rats, but whether it is oriented towards rescue, social contact with others, or other goals remains unclear. Therefore, we investigated whether helping-like behaviour could be observed in mice similar to that in rats. Because mice are social animals widely used in neuroscience, the discovery of helping-like behaviour in mice would be valuable in clarifying the psychological and biological mechanisms underlying pro-sociability. We constrained mice inside tubes. Subject mice were allowed to move freely in cages with tubes containing constrained conspecifics. The subject mice released both cagemates and stranger mice but did not engage in opening empty tubes. Furthermore, the same behaviour was observed under aversive conditions and with anesthetised conspecifics. Interestingly, hungry mice opened the tubes containing food before engaging in tube-opening behaviour to free constrained conspecifics. Mice showed equal preferences for constrained and freely moving conspecifics. We demonstrated for the first time that mice show tube-opening behaviour. Furthermore, we partly clarified the purpose and motivation of this behaviour. An effective mouse model for helping-like behaviour would facilitate research on the mechanisms underlying prosocial behaviour. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MurakamiShinji en-aut-sei=Murakami en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitamuraNaoya en-aut-sei=Kitamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WaniKenta en-aut-sei=Wani en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IshiharaTakeshi en-aut-sei=Ishihara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=2 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=3 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Graduate School of Health Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue= article-no= start-page=4009 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201938 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Synthesis of the extended phenacene molecules, [10]phenacene and [11]phenacene, and their performance in a field-effect transistor en-subtitle= kn-subtitle= en-abstract= kn-abstract= The [10]phenacene and [11]phenacene molecules have been synthesized using a simple repetition of Wittig reactions followed by photocyclization. Sufficient amounts of [10]phenacene and [11]phenacene were obtained, and thin-film FETs using these molecules have been fabricated with SiO2 and ionic liquid gate dielectrics. These FETs operated in p-channel. The averaged measurements of field-effect mobility, <ƒÊ>, were 3.1(7)?~?10-2 and 1.11(4)?~?10-1?cm2 V-1 s-1, respectively, for [10]phenacene and [11]phenacene thin-film FETs with SiO2 gate dielectrics. Furthermore, [10]phenacene and [11]phenacene thin-film electric-double-layer (EDL) FETs with ionic liquid showed low-voltage p-channel FET properties, with <ƒÊ> values of 3(1) and 1(1)?cm2 V-1 s-1, respectively. This study also discusses the future utility of the extremely extended ƒÎ-network molecules [10]phenacene and [11]phenacene as the active layer of FET devices, based on the experimental results obtained. en-copyright= kn-copyright= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HamaoShino en-aut-sei=Hamao en-aut-mei=Shino kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=EguchiRitsuko en-aut-sei=Eguchi en-aut-mei=Ritsuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=GotoHidenori en-aut-sei=Goto en-aut-mei=Hidenori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=TakabayashiYasuhiro en-aut-sei=Takabayashi en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YenPaul Yu-Hsiang en-aut-sei=Yen en-aut-mei=Paul Yu-Hsiang kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=LiangLuo Uei en-aut-sei=Liang en-aut-mei=Luo Uei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=ChouChia-Wei en-aut-sei=Chou en-aut-mei=Chia-Wei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=HoffmannGermar en-aut-sei=Hoffmann en-aut-mei=Germar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=GohdaShin en-aut-sei=Gohda en-aut-mei=Shin kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SuginoHisako en-aut-sei=Sugino en-aut-mei=Hisako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=LiaosYen-Fa en-aut-sei=Liaos en-aut-mei=Yen-Fa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IshiiHirofumi en-aut-sei=Ishii en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KubozonoYoshihiro en-aut-sei=Kubozono en-aut-mei=Yoshihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= affil-num=1 en-affil= Department of Chemistry, Okayama University kn-affil= affil-num=2 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=3 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=4 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= affil-num=5 en-affil= Department of Chemistry, Okayama University kn-affil= affil-num=6 en-affil=Department of Physics, National Tsing Hua University kn-affil= affil-num=7 en-affil=Department of Physics, National Tsing Hua University kn-affil= affil-num=8 en-affil=Department of Physics, National Tsing Hua University kn-affil= affil-num=9 en-affil=Department of Physics, National Tsing Hua University kn-affil= affil-num=10 en-affil=NARD Co Ltd kn-affil= affil-num=11 en-affil=NARD Co Ltd kn-affil= affil-num=12 en-affil=National Synchrotron Radiation Center kn-affil= affil-num=13 en-affil=National Synchrotron Radiation Center kn-affil= affil-num=14 en-affil=Research Institute for Interdisciplinary Science, Okayama University kn-affil= END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=7 article-no= start-page=1412 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190303 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Influence of Numerical Aperture on Molten Area Formation in Fusion Micro-Welding of Glass by Picosecond Pulsed Laser en-subtitle= kn-subtitle= en-abstract= kn-abstract= Focusing condition such as numerical aperture (N.A.) has a great influence on the creation of molten area and the stable welding process in fusion micro-welding of glass. In this study, a picosecond pulsed laser of 1064 nm in wavelength and 12.5 ps in pulse duration was tightly focused inside a borosilicate glass using objective lenses of numerical apertures 0.45, 0.65, and 0.85 with spherical aberration correction. Influence of numerical aperture on molten area formation was experimentally investigated through analysis of focusing situation in glass, and movement of absorption point, and then molten area characteristics were discussed. It is concluded that N.A. of 0.65 with superior focusing characteristics can form a large and continuous molten area without cracks, which enables achievement of stable joining of glass material by picosecond pulsed laser. en-copyright= kn-copyright= en-aut-name=OuyangZhiyong en-aut-sei=Ouyang en-aut-mei=Zhiyong kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OginoYuta en-aut-sei=Ogino en-aut-mei=Yuta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SakagawaTomokazu en-aut-sei=Sakagawa en-aut-mei=Tomokazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkadaAkira en-aut-sei=Okada en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil= kn-affil= affil-num=5 en-affil=Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=ultrashort pulsed laser kn-keyword=ultrashort pulsed laser en-keyword=glass material kn-keyword=glass material en-keyword=absorption point kn-keyword=absorption point en-keyword=molten area kn-keyword=molten area en-keyword=numerical aperture kn-keyword=numerical aperture END start-ver=1.4 cd-journal=joma no-vol=60 cd-vols= no-issue=43 article-no= start-page=151189 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20190920 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Fluorescence properties of amido-substituted 2,3-naphthalimides: Excited-state intramolecular proton transfer (ESIPT) fluorescence and responses to Ca2+ ions en-subtitle= kn-subtitle= en-abstract= kn-abstract= 2,3-Naphthalimide derivatives incorporating trifluoroacetamido (3a) and methansulfonamido (3b) functionalities at the 1-position were prepared and their intramolecular excited state proton transfer (ESIPT) fluorescence and responses to metal ions were investigated. Compound 3a displayed normal fluorescence in the amide form in toluene and MeCN and no response to metal cations in the corresponding amidate ion form. In contrast, compound 3b gave off dual emission assignable to normal and ESIPT fluorescence. Additionally, the amidate form of compound 3b displayed off-on fluorescence response to Ca2+. en-copyright= kn-copyright= en-aut-name=WangLei en-aut-sei=Wang en-aut-mei=Lei kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=FujiiMayu en-aut-sei=Fujii en-aut-mei=Mayu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NambaMisa en-aut-sei=Namba en-aut-mei=Misa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YamajiMinoru en-aut-sei=Yamaji en-aut-mei=Minoru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkamotoHideki en-aut-sei=Okamoto en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=3 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=4 en-affil=Division of Molecular Science, Graduate School of Science and Engineering, Gunma University kn-affil= affil-num=5 en-affil=Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University kn-affil= en-keyword=Fluorescence kn-keyword=Fluorescence en-keyword=ESIPT kn-keyword=ESIPT en-keyword=Naphthalimide kn-keyword=Naphthalimide en-keyword=Ca2+ probe kn-keyword=Ca2+ probe END start-ver=1.4 cd-journal=joma no-vol=115 cd-vols= no-issue= article-no= start-page=108879 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201907 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Comprehensive behavioral study of the effects of vanillin inhalation in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Vanillin is widely used in food and cosmetics, among other substances, for its sweet smell. However, the neuropsychological effects of vanillin inhalation have not been elucidated. In this study, we investigated the effect of vanillin inhalation on mouse behavior. First, we investigated whether the aroma of vanillin was attractive or repulsive for mice. Thereafter, the mice inhaled vanillin for 20?min before each test in a series of behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, cotton bud biting, and Porsolt forced swim tests). In these tests, the mice showed a neutral response to vanillin. Mice that inhaled vanillin had a suppressed pain response in the hot plate test. In addition, the grip strength of the forelimbs of mice that inhaled vanillin was decreased. No significant differences were found between the mice inhaling vanillin and control mice in the open field, Y-maze, tail suspension, forced swimming, and aggression tests. These results show that vanillin inhalation has anti-nociceptive effects, similar to other routes of administration. The results also show that vanillin inhalation does not cause significant behavioral effects. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimadaAtsumi en-aut-sei=Shimada en-aut-mei=Atsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MurakamiShinji en-aut-sei=Murakami en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KitamuraNaoya en-aut-sei=Kitamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WaniKenta en-aut-sei=Wani en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TakahashiYu en-aut-sei=Takahashi en-aut-mei=Yu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=FujiwaraYuko en-aut-sei=Fujiwara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=IshiharaTakeshi en-aut-sei=Ishihara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare kn-affil= affil-num=2 en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College kn-affil= affil-num=3 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=7 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=8 en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=10 en-affil=Department of Health and Sports Science, Kawasaki University of Medical Welfare kn-affil= affil-num=11 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= en-keyword=Anti-nociceptive kn-keyword=Anti-nociceptive en-keyword=Vanillin kn-keyword=Vanillin en-keyword=Essential oil kn-keyword=Essential oil en-keyword=Inhalation kn-keyword=Inhalation en-keyword=Analgesia kn-keyword=Analgesia END start-ver=1.4 cd-journal=joma no-vol=6 cd-vols= no-issue= article-no= start-page=1 end-page=17 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform cortices en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the developing central nervous system (CNS), extracellular matrix (ECM) molecules have regulating roles such as in brain development, neural-circuit maturation, and synaptic-function control. However, excluding the perineuronal net (PNN) area, the distribution, constituent elements, and expression level of granular ECM molecules (diffuse ECM) present in the mature CNS remain unclear. Diffuse ECM molecules in the CNS share the components of PNNs and are likely functional. As cortical functions are greatly region-dependent, we hypothesized that ECM molecules would differ in distribution, expression level, and components in a region- and layer-dependent manner. We examined the layer-specific expression of several chondroitin sulfate proteoglycans (aggrecan, neurocan, and brevican), tenascin-R, Wisteria floribunda agglutinin (WFA)-positive molecules, hyaluronic acid, and link protein in the somatosensory and piriform cortices of mature mice. Furthermore, we investigated expression changes in WFA-positive molecules due to aging. In the somatosensory cortex, PNN density was particularly high at layer 4 (L4), but not all diffuse ECM molecules were highly expressed at L4 compared to the other layers. There was almost no change in tenascin-R and hyaluronic acid in any somatosensory-cortex layer. Neurocan showed high expression in L1 of the somatosensory cortex. In the piriform cortex, many ECM molecules showed higher expression in L1 than in the other layers. However, hyaluronic acid showed high expression in deep layers. Here, we clarified that ECM molecules differ in constituent elements and expression in a region- and layer-dependent manner. Region-specific expression of ECM molecules is possibly related to functions such as region-specific plasticity and vulnerability. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MurakamiShinji en-aut-sei=Murakami en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KitamuraNaoya en-aut-sei=Kitamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=WaniKenta en-aut-sei=Wani en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=IshiharaTakeshi en-aut-sei=Ishihara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare kn-affil= affil-num=2 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=3 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=7 en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= en-keyword=Extracellular matrix kn-keyword=Extracellular matrix en-keyword=Perineuronal nets kn-keyword=Perineuronal nets en-keyword=Piriform cortex kn-keyword=Piriform cortex en-keyword=Proteoglycans kn-keyword=Proteoglycans en-keyword=Somatosensory cortex kn-keyword=Somatosensory cortex en-keyword=Wisteria floribunda kn-keyword=Wisteria floribunda END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue=6 article-no= start-page=e01945 end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=201906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Rosa gallica, a plant of the Rosa genus, has been used widely since the 13th century and is cultivated in many areas as a medicinal plant for the preparation of herbal medicines. However, details of the neuropsychological effects of R. gallica remain unclear; therefore we aimed to investigate the neuropsychological effects of a water-soluble extract of R. gallica in male C57BL/6N mice under normal conditions and under chronic stress. We administered a water-soluble extract of R. gallica to mice and performed a series of behavioral experiments to compare the treated animals with the untreated controls. No significant differences in activity level, anxiety-like behavior, depression-like behavior, body weight, and body temperature were observed between R. gallica-treated mice and control mice. However, in mice subjected to chronic stress, the observed decrease in activity was smaller in the R. gallica-treated mice than in the control mice. The oral administration of R. gallica did not affect the normal behavior of mice. However, when the mice were subjected to stress, R. gallica exerted an anti-stress effect. Therefore, R. gallica has potential as a medicinal plant for the purpose of stress prevention. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimadaAtsumi en-aut-sei=Shimada en-aut-mei=Atsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MurakamiShinji en-aut-sei=Murakami en-aut-mei=Shinji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KitamuraNaoya en-aut-sei=Kitamura en-aut-mei=Naoya kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=WaniKenta en-aut-sei=Wani en-aut-mei=Kenta kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=FujiwaraYuko en-aut-sei=Fujiwara en-aut-mei=Yuko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=IshiharaTakeshi en-aut-sei=Ishihara en-aut-mei=Takeshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= affil-num=1 en-affil=Department of Medical Technology, Kawasaki University of Medical Welfare kn-affil= affil-num=2 en-affil=Division of Food and Nutrition, Nakamura Gakuen University Junior College kn-affil= affil-num=3 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=4 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=5 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=6 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= affil-num=7 en-affil=Department of Neuropsychiatry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=8 en-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University kn-affil= affil-num=9 en-affil=Department of Health and Sports Science, Kawasaki University of Medical Welfare kn-affil= affil-num=10 en-affil=Department of Psychiatry, Kawasaki Medical School kn-affil= en-keyword=Neuroscience kn-keyword=Neuroscience en-keyword=Physiology kn-keyword=Physiology END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue=1 article-no= start-page=197 end-page=200 dt-received= dt-revised= dt-accepted= dt-pub-year=2019 dt-pub=20191231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=High surface quality micro machining of monocrystalline diamond by picosecond pulsed laser en-subtitle= kn-subtitle= en-abstract= kn-abstract=In micro machining of monocrystalline diamond by pulsed laser, unique processing characteristics appeared only under a few ten picosecond pulse duration and a certain overlap rate of laser shot. Cracks mostly propagate in parallel direction to top surface of workpiece, although the laser beam axis is perpendicular to the surface. This processed area can keep diamond structure, and its surface roughness is smaller than R-a = 0.2 mu M. New laser micro machining method to keep diamond structure and small surface roughness is proposed. This method can contribute to reduce the polishing process in micro machining of diamond. (C) 2019 Published by Elsevier Ltd on behalf of CIRP. en-copyright= kn-copyright= en-aut-name=OkamotoY. en-aut-sei=Okamoto en-aut-mei=Y. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkadaA. en-aut-sei=Okada en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KajitaniA. en-aut-sei=Kajitani en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShinonagaT. en-aut-sei=Shinonaga en-aut-mei=T. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Graduate School of Natural Science & Technology, Okayama University kn-affil= affil-num=2 en-affil=Graduate School of Natural Science & Technology, Okayama University kn-affil= affil-num=3 en-affil=Graduate School of Natural Science & Technology, Okayama University kn-affil= affil-num=4 en-affil=Graduate School of Natural Science & Technology, Okayama University kn-affil= en-keyword=Laser beam machining (LBM) kn-keyword=Laser beam machining (LBM) en-keyword=Laser micro machining kn-keyword=Laser micro machining en-keyword=Diamond kn-keyword=Diamond END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=1 article-no= start-page=1 end-page=3 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180402 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The 2016 Incentive Award of the Okayama Medical Association in General Medical Science (2016 Yuuki Prize) kn-title=•½¬28”N“x‰ªŽRˆãŠw‰ïÜ@‘‡Œ¤‹†§—ãÜiŒ‹éÜj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoSachiyo en-aut-sei=Okamoto en-aut-mei=Sachiyo kn-aut-name=‰ª–{K‘ã kn-aut-sei=‰ª–{ kn-aut-mei=K‘ã aut-affil-num=1 ORCID= affil-num=1 en-affil=Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@ŒŒ‰tEŽîá‡EŒÄ‹zŠí“à‰ÈŠw END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=•a‰@‚Å“­‚­¸_‰ÈŠÅŒìŽt‚ªƒŠƒJƒoƒŠ[‚ÌŠT”O‚ð—‰ð‚·‚邽‚ß‚Ì‘ÌŒ±ƒvƒƒOƒ‰ƒ€‚Ì•]‰¿ kn-title=Evaluation of an experience-based program to understand the concept of recovery amonghospital-based psychiatric nurses en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoAki en-aut-sei=Okamoto en-aut-mei=Aki kn-aut-name=‰ª–{ˆŸ‹I kn-aut-sei=‰ª–{ kn-aut-mei=ˆŸ‹I aut-affil-num=1 ORCID= affil-num=1 en-affil=Graduate School of Health Sciences, Okayama University kn-affil=‰ªŽR‘åŠw‘åŠw‰@•ÛŒ’ŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=129 cd-vols= no-issue=2 article-no= start-page=93 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The development of a scale to measure stress recognition during the treatment of diabetes patients kn-title=“œ”A•aŠ³ŽÒ‚ÌuŽ¡—Âɔº‚¤ƒXƒgƒŒƒX”F’mŽÚ“xv‚ÌŠJ”­ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@The purpose of this study was to establish a measurement scale for "stress recognition in receiving treatment" in patients with diabetes. A self-completed questionnaire was distributed to 149 type-2 diabetes outpatients in March-May 2015 after authorization from Okayama Prefectural University and the ethics committee of the hospital. @The "stress recognition in receiving treatment" scale was designed as a second-order factor model consisting of 14 items and the following four factors : the respondent's sense of (1) the burden of being sick, (2) the burden on interpersonal relationships, (3) the burden of treatment, and (4) the burden of medical expenses. @Stress recognition in treatment means recognition of being stressed in the burdens related to the illness, interpersonal relationships, treatment and medical expenses. @The suitability of the questionnaire data was then evaluated with a structural equation model. The suitability of the factor model to the data satisfied the statistically acceptable standards as Comparative Fit Index (CFI) 0.931, Root Mean Square Error of Approximation (RMSEA) 0.096, Tucker-Lewis Index (TLI) 0.946. @As the construct validity was not examined by the scale created in this study or by existing scale, it was verified by using the degrees of mental healthiness and HbA1c that were proved to be associated with the sense of burden. @In addition, the construct validity of the questionnaire was supported by a significant correlation between the Japanese version of the WHO-Five Well-being Index (S-WHO-5-J) and the patients' HbA1c levels. The use of this measure is expected to contribute to the early detection of a decline in a diabetic patient's activities of daily living and to the early confirmation of patients' support status. en-copyright= kn-copyright= en-aut-name=SumiyoshiKazuko en-aut-sei=Sumiyoshi en-aut-mei=Kazuko kn-aut-name=Z‹g˜aŽq kn-aut-sei=Z‹g kn-aut-mei=˜aŽq aut-affil-num=1 ORCID= en-aut-name=KawataChieko en-aut-sei=Kawata en-aut-mei=Chieko kn-aut-name=ì“c’qŒbŽq kn-aut-sei=ì“c kn-aut-mei=’qŒbŽq aut-affil-num=2 ORCID= en-aut-name=OkamotoTatsuo en-aut-sei=Okamoto en-aut-mei=Tatsuo kn-aut-name=‰ª–{’C•v kn-aut-sei=‰ª–{ kn-aut-mei=’C•v aut-affil-num=3 ORCID= en-aut-name=OhashiMutsuko en-aut-sei=Ohashi en-aut-mei=Mutsuko kn-aut-name=‘å‹´–rŽq kn-aut-sei=‘å‹´ kn-aut-mei=–rŽq aut-affil-num=4 ORCID= en-aut-name=MikaneSakae en-aut-sei=Mikane en-aut-mei=Sakae kn-aut-name=›‰‹à‰h kn-aut-sei=›‰‹à kn-aut-mei=‰h aut-affil-num=5 ORCID= en-aut-name=TakabayashiNoriko en-aut-sei=Takabayashi en-aut-mei=Noriko kn-aut-name=‚—є͎q kn-aut-sei=‚—Ñ kn-aut-mei=”ÍŽq aut-affil-num=6 ORCID= en-aut-name=FutoyuYoshiko en-aut-sei=Futoyu en-aut-mei=Yoshiko kn-aut-name=‘¾“’DŽq kn-aut-sei=‘¾“’ kn-aut-mei=DŽq aut-affil-num=7 ORCID= en-aut-name=KimWoesook en-aut-sei=Kim en-aut-mei=Woesook kn-aut-name=‹àŠOi kn-aut-sei=‹à kn-aut-mei=ŠOi aut-affil-num=8 ORCID= en-aut-name=WadaJun en-aut-sei=Wada en-aut-mei=Jun kn-aut-name=˜a“c~ kn-aut-sei=˜a“c kn-aut-mei=~ aut-affil-num=9 ORCID= en-aut-name=ShikataKenichi en-aut-sei=Shikata en-aut-mei=Kenichi kn-aut-name=Žl•ûŒ«ˆê kn-aut-sei=Žl•û kn-aut-mei=Œ«ˆê aut-affil-num=10 ORCID= en-aut-name=NakajimaKazuo en-aut-sei=Nakajima en-aut-mei=Kazuo kn-aut-name=’†“ˆ˜a•v kn-aut-sei=’†“ˆ kn-aut-mei=˜a•v aut-affil-num=11 ORCID= affil-num=1 en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University kn-affil=‰ªŽRŒ§—§‘åŠw@•ÛŒ’•ŸŽƒŠw•” affil-num=2 en-affil=Health and Nursing Sciences Masters Program, Wakayama Medical University kn-affil=˜a‰ÌŽRŒ§—§ˆã‰È‘åŠw@‘åŠw‰@•ÛŒ’ŠÅŒìŠwŒ¤‹†‰È affil-num=3 en-affil=Ryobi General Research Institute of Community Care kn-affil=—¼”õ’nˆæƒPƒA‘‡Œ¤‹†Š affil-num=4 en-affil=Department of Nursing, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@ ŠÅŒì•” affil-num=5 en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University kn-affil=‰ªŽRŒ§—§‘åŠw@•ÛŒ’•ŸŽƒŠw•” affil-num=6 en-affil=Faculty of Health and Welfare Science, Okayama Prefectural University kn-affil=‰ªŽRŒ§—§‘åŠw@•ÛŒ’•ŸŽƒŠw•” affil-num=7 en-affil=School of Health Science and Social Welfare, Kibi International University kn-affil=‹g”õ‘Û‘åŠw@•ÛŒ’ˆã—ÕŸŽƒŠw•” affil-num=8 en-affil=College of Nursing Art and Science, University of Hyogo kn-affil=•ºŒÉŒ§—§‘åŠw@ŠÅŒìŠw•” affil-num=9 en-affil=Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@tE–ƉuE“à•ª”å‘ãŽÓ“à‰ÈŠw affil-num=10 en-affil=Center for Innovative Clinical Medicine, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@Vˆã—ÃŒ¤‹†ŠJ”­ƒZƒ“ƒ^[ affil-num=11 en-affil=Ryobi General Research Institute of Community Care kn-affil=—¼”õ’nˆæƒPƒA‘‡Œ¤‹†Š en-keyword=“œ”A•aŠ³ŽÒ (diabetes patients) kn-keyword=“œ”A•aŠ³ŽÒ (diabetes patients) en-keyword=Ž¡—à (treatment) kn-keyword=Ž¡—à (treatment) en-keyword=ƒXƒgƒŒƒX”F’m (stress recognition) kn-keyword=ƒXƒgƒŒƒX”F’m (stress recognition) en-keyword=ŽÚ“xŠJ”­ (development of a scale) kn-keyword=ŽÚ“xŠJ”­ (development of a scale) END start-ver=1.4 cd-journal=joma no-vol=J100-D cd-vols= no-issue=6 article-no= start-page=616 end-page=626 dt-received= dt-revised= dt-accepted= dt-pub-year=2017 dt-pub=20170601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An Efficient Algorithm to Determine Equivalence of Pipelined Dependency Graphs for Their Simplification kn-title=ƒpƒCƒvƒ‰ƒCƒ“‰»ˆË‘¶«ƒOƒ‰ƒt‚ðŠÈ’P‰»‚·‚邽‚ß‚ÌŒø—¦“I‚È“™‰¿«”»’èƒAƒ‹ƒSƒŠƒYƒ€ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@ˆË‘¶«ƒOƒ‰ƒt‚ÉŠî‚¢‚½”ñ“¯ŠúŽ®ƒpƒCƒvƒ‰ƒCƒ“§Œä‰ñ˜H‚ÌÝŒv•û–@‚ª’ñˆÄ‚³‚ê‚Ä‚¢‚éD‚±‚ÌÝŒv–@‚ÌÅI’iŠK‚É‚¨‚¢‚Ä‚ÍCˆË‘¶«ƒOƒ‰ƒt‚Æk¬‚µ‚½ˆË‘¶«ƒOƒ‰ƒt‚Ì“™‰¿«‚ð‰½“x‚àŒJ•Ô‚µ”»’è‚·‚邱‚Æ‚É‚æ‚èCŠÈ’P‰»‚µ‚½ˆË‘¶«ƒOƒ‰ƒt‚ª“¾‚ç‚ê‚éD‚µ‚©‚µC‚±‚Ì”»’è‚É‚Í‘½”‚Ìó‘Ô‚ð‚à‚ƒI[ƒgƒ}ƒgƒ“‚ðˆµ‚¤‚½‚ßC‚»‚ÌŒvŽZ—Ê‚Í‹É‚ß‚Ä‘å‚«‚¢D–{˜_•¶‚Å‚ÍC‚±‚Ì“™‰¿«”»’è‚Ì‚½‚ß‚ÌV‚½‚ÈŒø—¦“I‚ȃAƒ‹ƒSƒŠƒYƒ€‚ð’ñˆÄ‚·‚éD‚Ü‚¸CŠî–{‘€ì‚ÌŽÀs‡˜‚Ì”¼‡˜‚ðƒRƒ“ƒpƒNƒg‚É•\Œ»‚·‚邽‚ß‚ÉCŠî–{‘€ì’¼Œ‹ˆö‰ÊŠÖŒWƒOƒ‰ƒt O? ‚ð’è‹`‚·‚éDŽŸ‚ÉC•ª ŠòŒn—ñ‚²‚Æ‚É O? ‚Ì‚X“ñ‚‚̕”•ªƒOƒ‰ƒt‚ªˆê’v‚·‚é‚Æ‚«C‚©‚‚»‚Ì‚Æ‚«‚ÉŒÀ‚èC“ñ‚‚̈ˑ¶«ƒOƒ‰ƒt‚ª“™‰¿‚Å‚ ‚邱‚Æ‚ðØ–¾‚·‚éDX‚ÉC“™‰¿«‚Ì”»’è‚É•K—v‚È•ªŠòŒn—ñ‚̃TƒCƒY‚Æ”‚ª—LŒÀ‚Å‚ ‚邱‚Æ‚ðØ–¾‚·‚éDÅŒã‚ÉCãq‚ÌŒ´—‚ð—p‚¢‚½ƒAƒ‹ƒSƒŠƒYƒ€‚ÌŒvŽZ—Ê‚ª]—ˆ–@‚É”ä‚ׂđ啂ɬ‚³‚¢‚±‚Æ‚ðŽ¦‚·D en-copyright= kn-copyright= en-aut-name=KagotaniHiroto en-aut-sei=Kagotani en-aut-mei=Hiroto kn-aut-name=âÄ’J—Tl kn-aut-sei=âÄ’J kn-aut-mei=—Tl aut-affil-num=1 ORCID= en-aut-name=SugiyamaYuji en-aut-sei=Sugiyama en-aut-mei=Yuji kn-aut-name=™ŽR—T“ñ kn-aut-sei=™ŽR kn-aut-mei=—T“ñ aut-affil-num=2 ORCID= en-aut-name=OkamotoTakuji en-aut-sei=Okamoto en-aut-mei=Takuji kn-aut-name=‰ª–{‘쎢 kn-aut-sei=‰ª–{ kn-aut-mei=‘쎢 aut-affil-num=3 ORCID= affil-num=1 en-affil=Graduate School of Natural Science and Technology kn-affil=‰ªŽR‘åŠw‘åŠw‰@Ž©‘R‰ÈŠwŒ¤‹†‰È affil-num=2 en-affil=Graduate School of Natural Science and Technology kn-affil=‰ªŽR‘åŠw‘åŠw‰@Ž©‘R‰ÈŠwŒ¤‹†‰È affil-num=3 en-affil= kn-affil= en-keyword=”ñ“¯ŠúŽ®§Œä‰ñ˜H kn-keyword=”ñ“¯ŠúŽ®§Œä‰ñ˜H en-keyword=ƒpƒCƒvƒ‰ƒCƒ“ kn-keyword=ƒpƒCƒvƒ‰ƒCƒ“ en-keyword=ŠÈ’P‰» kn-keyword=ŠÈ’P‰» en-keyword=ˆö‰ÊŠÖŒW kn-keyword=ˆö‰ÊŠÖŒW END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20160930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=‹C‘Š•‚—V•¨Ž¿‚ɑ΂µ”½‰ž«‚ðŽ¦‚·G”}/ƒZƒ“ƒT—p•¡‡Þ—¿‚̃}ƒNƒƒTƒCƒY‚Å‚Ì\‘¢§Œä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoTakumi en-aut-sei=Okamoto en-aut-mei=Takumi kn-aut-name=‰ª–{‘ñ–¤ kn-aut-sei=‰ª–{ kn-aut-mei=‘ñ–¤ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=128 cd-vols= no-issue=3 article-no= start-page=207 end-page=212 dt-received= dt-revised= dt-accepted= dt-pub-year=2016 dt-pub=20161201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Long-term survival of two patients with esophageal neuroendocrine carcinoma who underwent multidisciplinary therapy kn-title=WŠw“IŽ¡—Âɂæ‚è’·Šú¶‘¶‚ª“¾‚ç‚ꂽH“¹_Œo“à•ª”åŠà‚Ì2 —á en-subtitle= kn-subtitle= en-abstract= kn-abstract=@Esophageal neuroendocrine carcinoma iECCj is rare and has a poor prognosis when presenting with vascular invasion and distant metastasis from an early stage. Multidisciplinary therapy with surgery, chemotherapy, and radiation therapy may prolong survival in patients with advanced ECC, but there is as yet no standard therapy for advanced ECC. We treated two patients who have achieved long-term survival i„ 4 yearsj who underwent multidisciplinary therapy, including chemotherapy, for ECC. Our experience with these two cases suggests that multidisciplinary therapy, including chemotherapy, may be effective for treating ECC at an advanced stage. en-copyright= kn-copyright= en-aut-name=GotodaTatsuhiro en-aut-sei=Gotoda en-aut-mei=Tatsuhiro kn-aut-name=Œã“¡“c’B—m kn-aut-sei=Œã“¡“c kn-aut-mei=’B—m aut-affil-num=1 ORCID= en-aut-name=KawanoSeiji en-aut-sei=Kawano en-aut-mei=Seiji kn-aut-name=ì–콎i kn-aut-sei=ì–ì kn-aut-mei=½Ži aut-affil-num=2 ORCID= en-aut-name=KonoYoshiyasu en-aut-sei=Kono en-aut-mei=Yoshiyasu kn-aut-name=‰Í–ì‹g‘× kn-aut-sei=‰Í–ì kn-aut-mei=‹g‘× aut-affil-num=3 ORCID= en-aut-name=MiuraKou en-aut-sei=Miura en-aut-mei=Kou kn-aut-name=ŽO‰YŒö kn-aut-sei=ŽO‰Y kn-aut-mei=Œö aut-affil-num=4 ORCID= en-aut-name=KanzakiHiromitsu en-aut-sei=Kanzaki en-aut-mei=Hiromitsu kn-aut-name=_è—mŒõ kn-aut-sei=_è kn-aut-mei=—mŒõ aut-affil-num=5 ORCID= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=ŠâŽº‰ë–ç kn-aut-sei=ŠâŽº kn-aut-mei=‰ë–ç aut-affil-num=6 ORCID= en-aut-name=KawaharaYoshiro en-aut-sei=Kawahara en-aut-mei=Yoshiro kn-aut-name=‰ÍŒ´Ë˜N kn-aut-sei=‰ÍŒ´ kn-aut-mei=˘N aut-affil-num=7 ORCID= en-aut-name=TanakaTakehiro en-aut-sei=Tanaka en-aut-mei=Takehiro kn-aut-name=“c’†Œ’‘å kn-aut-sei=“c’† kn-aut-mei=Œ’‘å aut-affil-num=8 ORCID= en-aut-name=YoshinoTadashi en-aut-sei=Yoshino en-aut-mei=Tadashi kn-aut-name=‹g–ì³ kn-aut-sei=‹g–ì kn-aut-mei=³ aut-affil-num=9 ORCID= en-aut-name=ShirakawadYasuhiro en-aut-sei=Shirakawad en-aut-mei=Yasuhiro kn-aut-name=”’ì–õ”Ž kn-aut-sei=”’ì kn-aut-mei=–õ”Ž aut-affil-num=10 ORCID= en-aut-name=TabataMasahiro en-aut-sei=Tabata en-aut-mei=Masahiro kn-aut-name=“c’[‰ëO kn-aut-sei=“c’[ kn-aut-mei=‰ëO aut-affil-num=11 ORCID= en-aut-name=TanimotoMitsune en-aut-sei=Tanimoto en-aut-mei=Mitsune kn-aut-name=’J–{Œõ‰¹ kn-aut-sei=’J–{ kn-aut-mei=Œõ‰¹ aut-affil-num=12 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=‰ª“c—T”V kn-aut-sei=‰ª“c kn-aut-mei=—T”V aut-affil-num=13 ORCID= affil-num=1 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw affil-num=2 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw affil-num=3 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw affil-num=4 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw affil-num=5 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw affil-num=6 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw affil-num=7 en-affil=Department of Endoscopy, Okayama University Hospital kn-affil=‰ªŽR‘åŠw•a‰@@ŒõŠwˆã—Ãf—Õ” affil-num=8 en-affil=Department of Pathology, , Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@•a—ŠwiŽîᇕa—j affil-num=9 en-affil=Department of Pathology, , Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@•a—ŠwiŽîᇕa—j affil-num=10 en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@Á‰»ŠÇŠO‰ÈŠw affil-num=11 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@ŒŒ‰tEŽîᇓà‰ÈŠw affil-num=12 en-affil=Department of Hematology and Oncology, Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@ŒŒ‰tEŽîᇓà‰ÈŠw affil-num=13 en-affil=Department of Gastroenterology and Hepatology, Okayama University Graduate School of MedicineC Dentistry and Pharmaceutical Sciences kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw en-keyword=H“¹_Œo“à•ª”åŽîá‡iesophageal neuroendocrine carcinomaj kn-keyword=H“¹_Œo“à•ª”åŽîá‡iesophageal neuroendocrine carcinomaj en-keyword=¬×–EŠàismall cell carcinomaj kn-keyword=¬×–EŠàismall cell carcinomaj en-keyword=WŠw“IŽ¡—Ãimultidisciplinary therapyj kn-keyword=WŠw“IŽ¡—Ãimultidisciplinary therapyj END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150930 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=RIL-12/23 p40R‘Ì‚Í–«GVHD‚̃}ƒEƒXƒ‚ƒfƒ‹‚É‚¨‚¢‚ÄAIFN-ƒÁ/IL-17 double-producing×–E‚ð—}§‚·‚邱‚Æ‚ÅAGHVD‚ðŒyŒ¸‰»‚·‚é kn-title=Anti-IL-12/23 p40 Antibody Attenuates Experimental Chronic Graft-versus-Host Disease via Suppression of IFN-ƒÁ/IL-17-Producing Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoSachiyo en-aut-sei=Okamoto en-aut-mei=Sachiyo kn-aut-name=‰ª–{K‘ã kn-aut-sei=‰ª–{ kn-aut-mei=K‘ã aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ END start-ver=1.4 cd-journal=joma no-vol=130 cd-vols= no-issue=6 article-no= start-page=833 end-page=840 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100601 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ameliorative effect of propolis on insulin resistance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats kn-title=Propolis ’·Šú“Š—^‚É‚æ‚é Otsuka Long-Evans Tokushima Fatty (OLETF) ƒ‰ƒbƒg‚Ì ƒCƒ“ƒXƒŠƒ“’ïR«‰ü‘Pì—p en-subtitle= kn-subtitle= en-abstract= kn-abstract=Propolis is known to have abundant bioactive constituents and a variety of biological activities. To investigate the effect of Brazilian propolis on insulin resistance, 10-week-old Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a non-insulin-dependent type 2 diabetic model, were treated for 4 weeks with propolis (100 and 300 mg/kg, p.o.) or vehicle (control). Propolis treatment significantly decreased the plasma levels of insulin and insulin resistance index (Homeostasis Model Assessment-Insulin Resistance; HOM-IR), without affecting blood glucose levels and tended to lower systolic blood pressure compared with the control. In isolated and perfused mesenteric vascular beds of OLETF rats, propolis treatment resulted in significant reduction of sympathetic nerve-mediated vasoconstrictor response to periarterial nerve stimulation (PNS) and tended to increase calcitonin gene-related peptide (CGRP) nerve-mediated vasodilator response to PNS compared with in vehicle-treated OLETF rats. However, propolis treatment did not significantly affect the vasoconstrictor and vasodilator response to noradrenaline, CGRP, acetylcholine, and sodium nitroprusside. These results suggest that propolis could be an effective and functional food to prevent development of insulin resistance. en-copyright= kn-copyright= en-aut-name=ZamamiYoshito en-aut-sei=Zamami en-aut-mei=Yoshito kn-aut-name=ÀŠÔ–¡‹`l kn-aut-sei=ÀŠÔ–¡ kn-aut-mei=‹`l aut-affil-num=1 ORCID= en-aut-name=FujiwaraHiroki en-aut-sei=Fujiwara en-aut-mei=Hiroki kn-aut-name=“¡Œ´OŠì kn-aut-sei=“¡Œ´ kn-aut-mei=OŠì aut-affil-num=2 ORCID= en-aut-name=HosodaMiho en-aut-sei=Hosoda en-aut-mei=Miho kn-aut-name=דc”ü•ä kn-aut-sei=דc kn-aut-mei=”ü•ä aut-affil-num=3 ORCID= en-aut-name=HinoHayato en-aut-sei=Hino en-aut-mei=Hayato kn-aut-name=“ú–씹l kn-aut-sei=“ú–ì kn-aut-mei=”¹l aut-affil-num=4 ORCID= en-aut-name=HiraiKazuhiro en-aut-sei=Hirai en-aut-mei=Kazuhiro kn-aut-name=•½ˆä˜a_ kn-aut-sei=•½ˆä kn-aut-mei=˜a_ aut-affil-num=5 ORCID= en-aut-name=OkamotoKazuaki en-aut-sei=Okamoto en-aut-mei=Kazuaki kn-aut-name=‰ª–{˜a–¾ kn-aut-sei=‰ª–{ kn-aut-mei=˜a–¾ aut-affil-num=6 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‹à? kn-aut-sei=‹à kn-aut-mei=? aut-affil-num=7 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‚Žæ^Œá kn-aut-sei=‚Žæ kn-aut-mei=^Œá aut-affil-num=8 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‚–ØŽu^ kn-aut-sei=‚–Ø kn-aut-mei=Žu^ aut-affil-num=9 ORCID= en-aut-name=KawasakiHiromu en-aut-sei=Kawasaki en-aut-mei=Hiromu kn-aut-name=ìú±”ŽŒÈ kn-aut-sei=ìú± kn-aut-mei=”ŽŒÈ aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È—Õ°–òŠw•ª–ì affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È—Õ°–òŠw•ª–ì affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È—Õ°–òŠw•ª–ì affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È—Õ°–òŠw•ª–ì affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È—Õ°–òŠw•ª–ì affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È—Õ°–òŠw•ª–ì affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È—Õ°–òŠw•ª–ì affil-num=8 en-affil= kn-affil=“ú–{V–òŠ”Ž®‰ïŽÐ‘n–òŒ¤‹†Š affil-num=9 en-affil= kn-affil=ŽR“c—{–Iê–{ŽÐŒ¤‹†ŠJ”­•” affil-num=10 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È—Õ°–òŠw•ª–ì en-keyword=propolis kn-keyword=propolis en-keyword=insulin resistance kn-keyword=insulin resistance en-keyword=Otsuka Long-Evans Tokushima Fatty rat kn-keyword=Otsuka Long-Evans Tokushima Fatty rat en-keyword=periarterial nerve function kn-keyword=periarterial nerve function en-keyword=mesenteric vascular bed kn-keyword=mesenteric vascular bed END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=”–|”‚ÌÍo‹““®‚ÉŠÖ‚·‚éŠî‘bŒ¤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoRiki en-aut-sei=Okamoto en-aut-mei=Riki kn-aut-name=‰ª–{—Í kn-aut-sei=‰ª–{ kn-aut-mei=—Í aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ END start-ver=1.4 cd-journal=joma no-vol=127 cd-vols= no-issue=1 article-no= start-page=55 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Practical guideline for the management of allergic rhinitis in Japan kn-title=•@ƒAƒŒƒ‹ƒM[f—ÃKƒCƒhƒ‰ƒCƒ“\’Ê”N«•@‰Š‚Ɖԕ²Ç\ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MakiharaSeiichiro en-aut-sei=Makihara en-aut-mei=Seiichiro kn-aut-name=–qŒ´–õˆê˜Y kn-aut-sei=–qŒ´ kn-aut-mei=–õˆê˜Y aut-affil-num=1 ORCID= en-aut-name=OkanoMitsuhiro en-aut-sei=Okano en-aut-mei=Mitsuhiro kn-aut-name=‰ª–ìŒõ”Ž kn-aut-sei=‰ª–ì kn-aut-mei=Œõ”Ž aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ì˜JЕa‰@@Ž¨•@ˆôA‰ÈE“ªèò•”ŠO‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@Ž¨•@ˆôAE“ªèò•”ŠO‰ÈŠw END start-ver=1.4 cd-journal=joma no-vol=5 cd-vols= no-issue= article-no= 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en-aut-sei=Nishimoto en-aut-mei=Keiko kn-aut-name=¼–{Œ\Žq kn-aut-sei=¼–{ kn-aut-mei=Œ\Žq aut-affil-num=14 ORCID= en-aut-name=HinoYuko en-aut-sei=Hino en-aut-mei=Yuko kn-aut-name=“ú–ì—TŽq kn-aut-sei=“ú–ì kn-aut-mei=—TŽq aut-affil-num=15 ORCID= en-aut-name=MatumotoTomoko en-aut-sei=Matumoto en-aut-mei=Tomoko kn-aut-name=¼–{’qŽq kn-aut-sei=¼–{ kn-aut-mei=’qŽq aut-affil-num=16 ORCID= en-aut-name=IshiharaTomoko en-aut-sei=Ishihara en-aut-mei=Tomoko kn-aut-name=ÎŒ´’qŽq kn-aut-sei=ÎŒ´ kn-aut-mei=’qŽq aut-affil-num=17 ORCID= en-aut-name=TodoMariko en-aut-sei=Todo en-aut-mei=Mariko kn-aut-name=“¡“°^从q kn-aut-sei=“¡“° kn-aut-mei=^从q aut-affil-num=18 ORCID= en-aut-name=YamamotoKumiko en-aut-sei=Yamamoto en-aut-mei=Kumiko kn-aut-name=ŽR–{‹v”üŽq kn-aut-sei=ŽR–{ kn-aut-mei=‹v”üŽq aut-affil-num=19 ORCID= en-aut-name=SadamoriNatuki en-aut-sei=Sadamori en-aut-mei=Natuki kn-aut-name=’èX“ÞŒŽ kn-aut-sei=’èX kn-aut-mei=“ÞŒŽ aut-affil-num=20 ORCID= en-aut-name=YamagamiNao en-aut-sei=Yamagami en-aut-mei=Nao 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kn-affil=‘q•~Žs—§¼ˆ¢’m¬ŠwZ affil-num=15 en-affil= kn-affil=‘q•~Žs—§¼ˆ¢’m¬ŠwZ affil-num=16 en-affil= kn-affil=‘q•~Žs—§‘q•~“쬊wZ affil-num=17 en-affil= kn-affil=‘q•~Žs—§’†“‡¬ŠwZ affil-num=18 en-affil= kn-affil=‘q•~Žs—§’†“‡¬ŠwZ affil-num=19 en-affil= kn-affil=‘q•~Žs—§ˆ¯‚¬ŠwZ affil-num=20 en-affil= kn-affil=‘q•~Žs—§ˆ¯‚¬ŠwZ affil-num=21 en-affil= kn-affil=‘q•~Žs—§ˆ®‹u¬ŠwZ affil-num=22 en-affil= kn-affil=‘q•~Žs—§ˆ®‹u¬ŠwZ affil-num=23 en-affil= kn-affil=‘q•~Žs—§‘q•~Žx‰‡ŠwZ affil-num=24 en-affil= kn-affil=‘q•~Žs—§‘q•~Žx‰‡ŠwZ affil-num=25 en-affil= kn-affil=‘q•~Žs—§‘q•~Žx‰‡ŠwZ affil-num=26 en-affil= kn-affil=‘q•~Žs—§‘q•~Žx‰‡ŠwZ affil-num=27 en-affil= kn-affil=‘q•~Žs—§ˆ¯‚¬ŠwZ affil-num=28 en-affil= kn-affil=‘q•~Žs—§˜V¼¬ŠwZ affil-num=29 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È affil-num=30 en-affil= kn-affil=‚­‚炵‚«ì—z‘åŠw‚±‚Ç‚à‹³ˆçŠw•” en-keyword=¬ŠwZ kn-keyword=¬ŠwZ en-keyword=Œ’N‹³ˆç kn-keyword=Œ’N‹³ˆç en-keyword=‹i‰ŒEˆùŽðE–ò•¨——p–hŽ~‹³ˆç kn-keyword=‹i‰ŒEˆùŽðE–ò•¨——p–hŽ~‹³ˆç en-keyword=—{Œì‹³—@ kn-keyword=—{Œì‹³—@ en-keyword=’†Šj“I–ðŠ„ kn-keyword=’†Šj“I–ðŠ„ END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=127 end-page=131 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Fermented persimmon extract (kaki-shibu) is useful as a standard for component analyses of persimmon phytobezoars kn-title=Š`ˆÝ΂̬•ª•ªÍ‚É‚¨‚¯‚é•W€•¨Ž¿‚Æ‚µ‚Ä‚ÌŠ`a‚Ì—L—p« en-subtitle= kn-subtitle= en-abstract= kn-abstract=The definite diagnosis of persimmon phytobezoar (i.e., diospyrobezoar) is often accomplished by a component analysis using infrared spectroscopy. However, no studies have been conducted to investigate which substance is the best as a standard for the component analysis. Here we analyzed tannic acid, Japanese persimmon (kaki), fermented persimmon extract (kaki-shibu), conventional dried persimmon, and dried persimmon smoked in sulfur (ampo-kaki) by infrared spectroscopy to determine which would be optimal as a component analysis standard. The spectrum between 1,600 to 600cm|1 of a persimmon phytobezoar was quite similar to the spectrum of kaki-shibu rather than that of tannic acid. Consequently, we conclude that kaki-shibu should be used as a standard for infrared spectroscopy analyses of persimmon phytobezoars. en-copyright= kn-copyright= en-aut-name=IwamuroMasaya en-aut-sei=Iwamuro en-aut-mei=Masaya kn-aut-name=ŠâŽº‰ë–ç kn-aut-sei=ŠâŽº kn-aut-mei=‰ë–ç aut-affil-num=1 ORCID= en-aut-name=OkamotoYuko en-aut-sei=Okamoto en-aut-mei=Yuko kn-aut-name=‰ª–{—TŽq kn-aut-sei=‰ª–{ kn-aut-mei=—TŽq aut-affil-num=2 ORCID= en-aut-name=MurataToshihiro en-aut-sei=Murata en-aut-mei=Toshihiro kn-aut-name=‘º“c”NO kn-aut-sei=‘º“c kn-aut-mei=”NO aut-affil-num=3 ORCID= en-aut-name=KawaiYoshinari en-aut-sei=Kawai en-aut-mei=Yoshinari kn-aut-name=‰Í‡—Ǭ kn-aut-sei=‰Í‡ kn-aut-mei=—Ǭ aut-affil-num=4 ORCID= en-aut-name=ShirahaHidenori en-aut-sei=Shiraha en-aut-mei=Hidenori kn-aut-name=”’‰H‰p‘¥ kn-aut-sei=”’‰H kn-aut-mei=‰p‘¥ aut-affil-num=5 ORCID= en-aut-name=OkadaHiroyuki en-aut-sei=Okada en-aut-mei=Hiroyuki kn-aut-name=‰ª“c—T”V kn-aut-sei=‰ª“c kn-aut-mei=—T”V aut-affil-num=6 ORCID= en-aut-name=YamamotoKazuhide en-aut-sei=Yamamoto en-aut-mei=Kazuhide kn-aut-name=ŽR–{˜aG kn-aut-sei=ŽR–{ kn-aut-mei=˜aG aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw affil-num=2 en-affil= kn-affil=ˆäŒ´Žs—§ˆäŒ´Žs–¯•a‰@@“à‰È affil-num=3 en-affil= kn-affil=”ö“¹Žs—§Žs–¯•a‰@ ŠO‰È affil-num=4 en-affil= kn-affil=”ö“¹Žs—§Žs–¯•a‰@ Á‰»Ší“à‰È affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@ŒõŠwˆã—Ãf—Õ” affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È Á‰»ŠíEŠÌ‘Ÿ“à‰ÈŠw en-keyword=Š`ˆÝÎigastric phytobezoarj kn-keyword=Š`ˆÝÎigastric phytobezoarj en-keyword=ƒ^ƒ“ƒjƒ“Ž_itannic acidj kn-keyword=ƒ^ƒ“ƒjƒ“Ž_itannic acidj en-keyword=Á‰»ŠÇˆÙ•¨igastrointestinal foreign bodyj kn-keyword=Á‰»ŠÇˆÙ•¨igastrointestinal foreign bodyj en-keyword=¬•ª•ªÍicomponent analysisj kn-keyword=¬•ª•ªÍicomponent analysisj END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=2 article-no= start-page=117 end-page=126 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The origin of infra-slow oscillations of oxygenated hemoglobin observed in functional near-infrared spectroscopy kn-title=Œõƒgƒ|ƒOƒ‰ƒtƒB[‚Å‚Ý‚ç‚ê‚éŽ_‘f‰»ƒwƒ‚ƒOƒƒrƒ“—Ê‚Ì’áŽü”g•Ï“®‚Ì”­¶Œ¹‚ÉŠÖ‚·‚錤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=There is increasing interest in the intrinsic activity of the resting brain, especially the activity slower than 0.1Hz (i.e., low-frequency oscillations, or LFOs). To investigate the origin of LFOs observed in functional near-infrared spectroscopy (fNIRS), we recorded multichannel fNIRS and electroencephalography (EEG) from the frontal cortex of 11 healthy young volunteers in the resting state. Electrocardiography (ECG), electro-oculography and respiration were also measured. Synchronous oscillations of oxy-hemoglobin (oxy-Hb) around 1.0Hz were detected in all fNIRS channels, and their frequency was consistent with a peak frequency of ECG, suggesting the changes of cerebral blood flow due to heart beats. In addition, oxy-Hb oscillations around 0.1Hz (i.e., LFOs) appeared in the fNIRS. The channels where LFOs appeared differed among the subjects, and the LFOs appeared or disappeared even in the same fNIRS channels. The appearance of LFOs in fNIRS channels was significantly higher when the LFOs appeared on the EEG in the adjacent EEG electrodes compared to when LFOs did not appear on EEG. The amplitude and coherence (synchronicity) of the LFOs were increased by changing the subjects' position from dorsal to the sitting position in both fNIRS and EEG, and the coherence in particular was increased in the homologous fNIRS channels on the bilateral hemispheres. These results suggest that LFOs of oxy-Hb couple with resting-state EEG activity. en-copyright= kn-copyright= en-aut-name=ShoshiChikafumi en-aut-sei=Shoshi en-aut-mei=Chikafumi kn-aut-name=ŠŽi–r•¶ kn-aut-sei=ŠŽi kn-aut-mei=–r•¶ aut-affil-num=1 ORCID= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name=ã–ì_Ži kn-aut-sei=ã–ì kn-aut-mei=_Ži aut-affil-num=2 ORCID= en-aut-name=KuboMasako en-aut-sei=Kubo en-aut-mei=Masako kn-aut-name=‹v•Û³Žq kn-aut-sei=‹v•Û kn-aut-mei=³Žq aut-affil-num=3 ORCID= en-aut-name=OdaMasuko en-aut-sei=Oda en-aut-mei=Masuko kn-aut-name=¬“c^ŽìŽq kn-aut-sei=¬“c kn-aut-mei=^ŽìŽq aut-affil-num=4 ORCID= en-aut-name=HirataNaoya en-aut-sei=Hirata en-aut-mei=Naoya kn-aut-name=•½“c’¼–ç kn-aut-sei=•½“c kn-aut-mei=’¼–ç aut-affil-num=5 ORCID= en-aut-name=TakemotoRika en-aut-sei=Takemoto en-aut-mei=Rika kn-aut-name=•–{—œ‰À kn-aut-sei=•–{ kn-aut-mei=—œ‰À aut-affil-num=6 ORCID= en-aut-name=KinugasaKazushi en-aut-sei=Kinugasa en-aut-mei=Kazushi kn-aut-name=ˆßŠ}˜aŽy kn-aut-sei=ˆßŠ} kn-aut-mei=˜aŽy aut-affil-num=7 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=‰ª–{Šî kn-aut-sei=‰ª–{ kn-aut-mei=Šî aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã—Ã’ZŠú‘åŠw@—Õ°ŒŸ¸‰È affil-num=2 en-affil= kn-affil=‹ß‹E‘åŠwˆãŠw•”@–ò—ŠwuÀ affil-num=3 en-affil= kn-affil=“Œ‹žH‰È‘åŠwˆã—Õی’Šw•”@ŠÅŒìŠw‰È affil-num=4 en-affil= kn-affil=‘q•~¬l•aŒ’fƒZƒ“ƒ^[ affil-num=5 en-affil= kn-affil=•ŸŽRŽs–¯•a‰@ affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@ˆã—ËZp•” affil-num=7 en-affil= kn-affil=‰ªŽR—ÃŒìƒZƒ“ƒ^[ affil-num=8 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@•ÛŒ’ŠwŒ¤‹†‰È@ŒŸ¸‹Zp‰ÈŠw en-keyword=fNIRS kn-keyword=fNIRS en-keyword=EEG kn-keyword=EEG en-keyword=LFOs kn-keyword=LFOs en-keyword=ƒRƒq[ƒŒƒ“ƒX‰ðÍiCoherence analysisj kn-keyword=ƒRƒq[ƒŒƒ“ƒX‰ðÍiCoherence analysisj en-keyword=˜A‘±ƒEƒF[ƒuƒŒƒbƒg‰ðÍicontinuous wavelet transformsj kn-keyword=˜A‘±ƒEƒF[ƒuƒŒƒbƒg‰ðÍicontinuous wavelet transformsj END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131231 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=¬Ž™‚Ì•a‰@ŠOS’âŽ~Ç—á‚Ì“Á’¥‚Æ“]‹A‚ɂ‚¢‚Ä‚Ì’nˆæ·‚ÉŠÖ‚·‚錟“¢ kn-title=Regional Variation in Survival Following Pediatric Out-of-Hospital Cardiac Arrest en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoYoshio en-aut-sei=Okamoto en-aut-mei=Yoshio kn-aut-name=‰ª–{‹g¶ kn-aut-sei=‰ª–{ kn-aut-mei=‹g¶ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=58 cd-vols= no-issue= article-no= start-page=27 end-page=41 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20121225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the influence of Zhen zhong ji in Song Shi kn-title=‘vŽ‚É‚Ý‚¦‚éu–’†‹Lv‚̉e‹¿‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoFujiaki en-aut-sei=Okamoto en-aut-mei=Fujiaki kn-aut-name=‰ª–{•s“ñ–¾ kn-aut-sei=‰ª–{ kn-aut-mei=•s“ñ–¾ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=39 end-page=43 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil kn-title=p‘ODCF—Ö@‚ª’˜Œø‚µ‚½H“¹Œ´”­“à•ª”å×–EŠà‚Ì‚PØœ—á en-subtitle= kn-subtitle= en-abstract= kn-abstract=@Esophageal endocrine cell carcinoma is extremely rare. We report a case of esophageal endocrine cell carcinoma showing histological complete response to neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (DCF). A 66-year-old man had been experiencing epigastralgia, and a type 2 tumor in the thoracic part of esophagus was detected by upper endoscopy. The biopsy showed endocrine cell carcinoma. PET/CT, endoscopy and an esophagogram showed that the patient had a 70-mm scaled type 2 tumor in the middle thoracic esophagus, and they also revealed lymph node metastases (no. 106recR). We diagnosed a cT3cN1cM0 cStage III tumor. With two courses of DCF treatment, both the primary tumor and lymph node metastases showed a partial response. We performed a subtotal esophagectomy with three-field lymph node dissection. The pathological examination of the resected specimens revealed no malignant cells in the esophagus or lymph nodes, and we concluded that the pathological effect of the DCF treatment was Grade 3. en-copyright= kn-copyright= en-aut-name=MaedaNaoaki en-aut-sei=Maeda en-aut-mei=Naoaki kn-aut-name=‘O“c’¼Œ© kn-aut-sei=‘O“c kn-aut-mei=’¼Œ© aut-affil-num=1 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=”’ì–õ”Ž kn-aut-sei=”’ì kn-aut-mei=–õ”Ž aut-affil-num=2 ORCID= en-aut-name=KoujimaTakeshi en-aut-sei=Koujima en-aut-mei=Takeshi kn-aut-name=š •{“‡Œ’ kn-aut-sei=š •{“‡ kn-aut-mei=Œ’ aut-affil-num=3 ORCID= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name=‘匴—˜Í kn-aut-sei=‘匴 kn-aut-mei=—˜Í aut-affil-num=4 ORCID= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name=“cç²r•ã kn-aut-sei=“cç² kn-aut-mei=r•ã aut-affil-num=5 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name=–ìŠÔ˜aL kn-aut-sei=–ìŠÔ kn-aut-mei=˜aL aut-affil-num=6 ORCID= en-aut-name=SakuramaKazuhumi en-aut-sei=Sakurama en-aut-mei=Kazuhumi kn-aut-name=ŸNŠÔ‹³•¶ kn-aut-sei=ŸNŠÔ kn-aut-mei=‹³•¶ aut-affil-num=7 ORCID= en-aut-name=FujiwaraToshiyosi en-aut-sei=Fujiwara en-aut-mei=Toshiyosi kn-aut-name=“¡Œ´r‹` kn-aut-sei=“¡Œ´ kn-aut-mei=r‹` aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=8 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È en-keyword=H“¹Šàiesophageal cancerj kn-keyword=H“¹Šàiesophageal cancerj en-keyword=“à•ª”å×–EŠàiendocrine cell carcinomaj kn-keyword=“à•ª”å×–EŠàiendocrine cell carcinomaj en-keyword=DCF—Ö@iDCF treatmentj kn-keyword=DCF—Ö@iDCF treatmentj END start-ver=1.4 cd-journal=joma no-vol=126 cd-vols= no-issue=1 article-no= start-page=35 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2014 dt-pub=20140401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of colon lipoma presenting with intussusception kn-title=’°dÏ‚Å”­Ç‚µ‚½Œ‹’°Ž‰–bŽî‚Ì‚P—á en-subtitle= kn-subtitle= en-abstract= kn-abstract=@An 84-year-old man, who had been found to have a submucosal tumor in the ascending colon two years before, was admitted to our hospital for right lower quadrant abdominal pain and melena. An abdominal computed tomography (CT) scan showed intussusception in the ascending colon, resulting from a fat-density tumor. The intussusception was located by colonoscopy. Since the colonic tumor was enlarged in comparison with two years ago and had an ulcer at the top of the tumor, there was the possibility of malignancy and recurrence of intussusception. He underwent a laparoscopy-assisted right colectomy with lymph node dissection. Pathologically, the tumor of the ascending colon was a benign lipoma. en-copyright= kn-copyright= en-aut-name=NinomiyaTakayuki en-aut-sei=Ninomiya en-aut-mei=Takayuki kn-aut-name=“ñ‹{‘ì”V kn-aut-sei=“ñ‹{ kn-aut-mei=‘ì”V aut-affil-num=1 ORCID= en-aut-name=OjimaYasutomo en-aut-sei=Ojima en-aut-mei=Yasutomo kn-aut-name=¬“‡N’m kn-aut-sei=¬“‡ kn-aut-mei=N’m aut-affil-num=2 ORCID= en-aut-name=HaranoMasao en-aut-sei=Harano en-aut-mei=Masao kn-aut-name=Œ´–ì‰ë¶ kn-aut-sei=Œ´–ì kn-aut-mei=‰ë¶ aut-affil-num=3 ORCID= en-aut-name=OhnoSatoshi en-aut-sei=Ohno en-aut-mei=Satoshi kn-aut-name=‘å–ì‘ kn-aut-sei=‘å–ì kn-aut-mei=‘ aut-affil-num=4 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=‰–莠O kn-aut-sei=‰–è kn-aut-mei=Ž O aut-affil-num=5 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=“ñ‹{ŠîŽ÷ kn-aut-sei=“ñ‹{ kn-aut-mei=ŠîŽ÷ aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È affil-num=2 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È affil-num=3 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È affil-num=4 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È affil-num=5 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È affil-num=6 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È en-keyword=Œ‹’°Ž‰–bŽîilipoma of the colonj kn-keyword=Œ‹’°Ž‰–bŽîilipoma of the colonj en-keyword=’°dÏiintussusceptionj kn-keyword=’°dÏiintussusceptionj en-keyword=• o‹¾‰ºŽèpilaparoscopic surgeryj kn-keyword=• o‹¾‰ºŽèpilaparoscopic surgeryj END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=3 article-no= start-page=239 end-page=242 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20131202 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of appendiceal diverticulum resected by laparoscopic surgery with preoperative diagnosis of appendiceal tumor kn-title=’Ž‚ŽîᇂÆp‘Of’f‚µ• o‹¾‰ºŽèp‚ðs‚Á‚½’Ž‚‰¼«ŒeŽºÇ‚Ì‚P—á en-subtitle= kn-subtitle= en-abstract= kn-abstract=@Appendiceal diverticulum is rare. We encountered a case of appendiceal diverticulum with chronic appendicitis. A 56-year-old man presented to our hospital with right lower abdominal pain. An abdominal computed tomography (CT) scan showed swelling of the appendix body and the wall thickness of the base of the appendix. Due to the possibility of appendiceal tumor, we performed a laparoscopy-assisted ileocecal resection with lymph node dissection. The appendix had a diverticulum with chronic inflammation, but it did not have a neoplastic lesion. en-copyright= kn-copyright= en-aut-name=NinomiyaTakayuki en-aut-sei=Ninomiya en-aut-mei=Takayuki kn-aut-name=“ñ‹{‘ì”V kn-aut-sei=“ñ‹{ kn-aut-mei=‘ì”V aut-affil-num=1 ORCID= en-aut-name=OjimaYasutomo en-aut-sei=Ojima en-aut-mei=Yasutomo kn-aut-name=¬“‡N’m kn-aut-sei=¬“‡ kn-aut-mei=N’m aut-affil-num=2 ORCID= en-aut-name=HaranoMasao en-aut-sei=Harano en-aut-mei=Masao kn-aut-name=Œ´–ì‰ë¶ kn-aut-sei=Œ´–ì kn-aut-mei=‰ë¶ aut-affil-num=3 ORCID= en-aut-name=OhnoSatoshi en-aut-sei=Ohno en-aut-mei=Satoshi kn-aut-name=‘å–ì‘ kn-aut-sei=‘å–ì kn-aut-mei=‘ aut-affil-num=4 ORCID= en-aut-name=ShiozakiShigehiro en-aut-sei=Shiozaki en-aut-mei=Shigehiro kn-aut-name=‰–莠O kn-aut-sei=‰–è kn-aut-mei=Ž O aut-affil-num=5 ORCID= en-aut-name=NinomiyaMotoki en-aut-sei=Ninomiya en-aut-mei=Motoki kn-aut-name=“ñ‹{ŠîŽ÷ kn-aut-sei=“ñ‹{ kn-aut-mei=ŠîŽ÷ aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È affil-num=2 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È affil-num=3 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È affil-num=4 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È affil-num=5 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È affil-num=6 en-affil= kn-affil=L“‡Žs—§L“‡Žs–¯•a‰@@ŠO‰È en-keyword=’Ž‚ŒeŽºÇiappendiceal diverculumj kn-keyword=’Ž‚ŒeŽºÇiappendiceal diverculumj en-keyword=• o‹¾Žèpilaparoscopic surgeryj kn-keyword=• o‹¾Žèpilaparoscopic surgeryj en-keyword=’Ž‚Žîá‡iappendiceal tumorj kn-keyword=’Ž‚Žîá‡iappendiceal tumorj END start-ver=1.4 cd-journal=joma no-vol=40 cd-vols= no-issue=2 article-no= start-page=103 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the microbiological decomposition of pectin. XII. Distribution of pectinase in higher plants. kn-title=ƒyƒNƒ`ƒ“”®y‚ÉA‚¢‚Ä ‘æ12•ñ ‚“™A•¨‚̃yƒNƒ`ƒi[ƒ[‚Ìžûo en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=1 ORCID= en-aut-name=OkamotoK. en-aut-sei=Okamoto en-aut-mei=K. kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=2 article-no= start-page=135 end-page=138 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical study of single-incision laparoscopic cholecystectomy kn-title=’PEŽ®• o‹¾‰º’_”X“Eop‚ÌŒŸ“¢ en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced 63 patients with non-inflammatory disease who underwent single-incision laparoscopic cholecystectomy (TANKO-LC). Herein we report the procedure of operation and the short-term results. We compared 63 cases of TANKO-LC with 109 cases of non-inflammatory conventional laparoscopic cholecystectomy (S-LC) within the same period. At first, our standard procedure was to insert multiple trocars in the abdominal cavity through a single wound ; now, we insert only a single trocar all cases. In the 63 cases investigation, 3 cases required trocar addition and one case converted to open surgery. Intra and postoperative complications were recognized in 2 cases (port-site infection). No significant complications were recognized. In comparing the TANKO-LC group and the S-LC group, the operation time was intentionally longer in the TANKO-LC group (TANKO-LC group : 118 min, S-LC group : 90 min), but there were no differences in the blood loss, the rates of intra and postoperative complications and the conversion rate. Laparoscopic cholecystectomy is a standard operation for gallbladder removal, but single-incision laparoscopic cholecystectomy is considered a useful operation with the same low operative complication rate yet more satisfactory cosmetic results. en-copyright= kn-copyright= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=‘å’ËáÁÆ kn-aut-sei=‘å’Ë kn-aut-mei=áÁÆ aut-affil-num=1 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=ˆîŠ_—D kn-aut-sei=ˆîŠ_ kn-aut-mei=—D aut-affil-num=2 ORCID= en-aut-name=IsodaKenta en-aut-sei=Isoda en-aut-mei=Kenta kn-aut-name=ˆé“cŒ’‘¾ kn-aut-sei=ˆé“c kn-aut-mei=Œ’‘¾ aut-affil-num=3 ORCID= en-aut-name=KitadaKouji en-aut-sei=Kitada en-aut-mei=Kouji kn-aut-name=–k“c_“ñ kn-aut-sei=–k“c kn-aut-mei=_“ñ aut-affil-num=4 ORCID= en-aut-name=HamanoRyousuke en-aut-sei=Hamano en-aut-mei=Ryousuke kn-aut-name=à_–ì—º•ã kn-aut-sei=à_–ì kn-aut-mei=—º•ã aut-affil-num=5 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=¼]Šw kn-aut-sei=¼] kn-aut-mei=Šw aut-affil-num=6 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=“¿‰i®”V kn-aut-sei=“¿‰i kn-aut-mei=®”V aut-affil-num=7 ORCID= en-aut-name=TsunemitsuYousuke en-aut-sei=Tsunemitsu en-aut-mei=Yousuke kn-aut-name=íŒõ—m•ã kn-aut-sei=íŒõ kn-aut-mei=—m•ã aut-affil-num=8 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=Šâì˜aG kn-aut-sei=Šâì kn-aut-mei=˜aG aut-affil-num=9 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=ŠâŠ_”Ž–¤ kn-aut-sei=ŠâŠ_ kn-aut-mei=”Ž–¤ aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[ ŠO‰È affil-num=2 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[ ŠO‰È affil-num=3 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[ ŠO‰È affil-num=4 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[ ŠO‰È affil-num=5 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[ ŠO‰È affil-num=6 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[ ŠO‰È affil-num=7 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[ ŠO‰È affil-num=8 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[ ŠO‰È affil-num=9 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[ ŠO‰È affil-num=10 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[ ŠO‰È en-keyword=• o‹¾‰º’_”X“Eopilaparoscopic cholecystectomyj kn-keyword=• o‹¾‰º’_”X“Eopilaparoscopic cholecystectomyj en-keyword=’PEŽ®isingle-incisionj kn-keyword=’PEŽ®isingle-incisionj END start-ver=1.4 cd-journal=joma no-vol=50 cd-vols= no-issue=2 article-no= start-page=61 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=196403 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The thiobarbituric acid test of 4,5-unsaturated digalacturonic acid. kn-title=4,5-•s–O˜aƒaƒKƒ‰ƒNƒ`ƒ…ƒƒ“Ž_‚̃`ƒIƒoƒ‹ƒrƒc[ƒ‹Ž_”½‰ž en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoK. en-aut-sei=Okamoto en-aut-mei=K. kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=1 ORCID= en-aut-name=HatanakaC. en-aut-sei=Hatanaka en-aut-mei=C. kn-aut-name=”¨’†çÎ kn-aut-sei=”¨’† kn-aut-mei=çÎ aut-affil-num=2 ORCID= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=49 cd-vols= no-issue=3 article-no= start-page=137 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=1962 dt-pub=196203 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the metabolism of uronic acids. 3. Properties of an intermediate in pectic acid metabolism by Erwinia aroideae: Products by ozone and periodate Oxidation. kn-title=ƒEƒƒ“Ž_‚Ì‘ãŽÓ‚ÉŠÖ‚·‚錤‹†(3)@Erwinia aroideae‚É‚æ‚éƒyƒNƒ`ƒ“Ž_‚Ì‘ãŽÓ’†ŠÔ¶¬•¨‚Ì«Ž¿\ƒIƒ]ƒ“Ž_‰»‚Ɖߗ€‘fŽ_Ž_‰»‚É‚æ‚鶬•¨ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoK. en-aut-sei=Okamoto en-aut-mei=K. kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=1 ORCID= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=67 cd-vols= no-issue=3 article-no= start-page=135 end-page=143 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=201306 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Somatosensory and Visual Deprivation Each Decrease the Density of Parvalbumin Neurons and Their Synapse Terminals in the Prefrontal Cortex and Hippocampus of Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the phenomenon known as cross-modal plasticity, the loss of one sensory system is followed by improved functioning of other intact sensory systems. MRI and functional MRI studies suggested a role of the prefrontal cortex and the temporal lobe in cross-modal plasticity. We used a mouse model to examine the effects of sensory deprivation achieved by whisker trimming and visual deprivation achieved by dark rearing in neonatal mice on the appearance of parvalbumin (PV) neurons and the formation of glutamic acid decarboxylase 67 (GAD67)-positive puncta around pyramidal neurons in the prefrontal cortex and hippocampus. Whisker trimming, but not dark rearing, decreased the density of PV neurons in the hippocampus at postnatal day 28 (P28). In the prefrontal cortex, whisker trimming and dark rearing decreased the density of PV neurons in layer 5/6 (L5/6) at P28 and in L2/3 at P56, respectively, whereas dark rearing increased the density of PV neurons in L5/6 at P56. Whisker trimming decreased the density of GAD67-positive puncta in CA1 of the hippocampus at both P28 and P56 and in L5/6 of the prefrontal cortex at P28. Dark rearing decreased the density of GAD67-positive puncta in CA1 of the hippocampus and in both L2/3 and L5/6 of the prefrontal cortex at P28, and in L2/3 of the prefrontal cortex at P56. These results demonstrate that somatosensory or visual deprivation causes changes in the PV-interneuronal network in the mouse prefrontal cortex and hippocampus. The results also suggest that the alteration of the PV-interneuronal network, especially in the prefrontal cortex, may contribute to cross-modal plasticity. en-copyright= kn-copyright= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShoshiChikafumi en-aut-sei=Shoshi en-aut-mei=Chikafumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=UsuiShinichi en-aut-sei=Usui en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SujiuraHiroko en-aut-sei=Sujiura en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Department of Medical Technology, Kawasaki College of Allied Health Professions affil-num=3 en-affil= kn-affil=Department of Psychiatry, Kawasaki Medical University affil-num=4 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=5 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=6 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University en-keyword=sensory deprivation kn-keyword=sensory deprivation en-keyword=parvalbumin kn-keyword=parvalbumin en-keyword=glutamate decarboxylase (GAD67) kn-keyword=glutamate decarboxylase (GAD67) en-keyword=prefrontal cortex kn-keyword=prefrontal cortex en-keyword=hippocampus kn-keyword=hippocampus END start-ver=1.4 cd-journal=joma no-vol=48 cd-vols= no-issue=1 article-no= start-page=39 end-page=47 dt-received= dt-revised= dt-accepted= dt-pub-year=1960 dt-pub=196012 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the metabolism of uronic acids. 2. Some properties of an intermediate compound in pectic acid metabolism by Erwinia aroideae. kn-title=ƒEƒƒ“Ž_‚Ì‘ãŽÓ‚ÉŠÖ‚·‚錤‹†i2j@Erwinia aroideae ‚É‚æ‚éƒyƒNƒ`ƒ“Ž_‚Ì‘ãŽÓ’†ŠÔ¶¬•¨‚Ì«Ž¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoK. en-aut-sei=Okamoto en-aut-mei=K. kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=1 ORCID= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=1-2 article-no= start-page=105 end-page=110 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195911 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the pectin-polygalacturonase of Saccharomyces fragilis. kn-title=Saccharomayces fragilis‚̃yƒNƒ`ƒ“\ƒ|ƒŠƒKƒ‰ƒNƒgƒEƒƒi[ƒ[‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OzawaJ. en-aut-sei=Ozawa en-aut-mei=J. kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=1 ORCID= en-aut-name=OkamotoA. en-aut-sei=Okamoto en-aut-mei=A. kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=2 ORCID= en-aut-name=HayashiT. en-aut-sei=Hayashi en-aut-mei=T. kn-aut-name=—Ñ“NŒá kn-aut-sei=—Ñ kn-aut-mei=“NŒá aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=47 cd-vols= no-issue=1-2 article-no= start-page=39 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195911 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the chemical control of white root-rot of vines. I. First screening test with fungicides in the liquid form. kn-title=ƒuƒhƒE”’–ä‰H•a‚Ì–òÜ–hœ‚ÉŠÖ‚·‚錤‹†@‘æ1•ñ@–òÜi‰tÜjƒXƒNƒŠ[ƒjƒ“ƒOƒeƒXƒg en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamauchiK. en-aut-sei=Yamauchi en-aut-mei=K. kn-aut-name=ŽR“àŒÈ“Ñ kn-aut-sei=ŽR“à kn-aut-mei=ŒÈ“Ñ aut-affil-num=1 ORCID= en-aut-name=ShiomiM. en-aut-sei=Shiomi en-aut-mei=M. kn-aut-name=‰–Œ©³•Û kn-aut-sei=‰–Œ© kn-aut-mei=³•Û aut-affil-num=2 ORCID= en-aut-name=OkamotoY. en-aut-sei=Okamoto en-aut-mei=Y. kn-aut-name=‰ª–{N”Ž kn-aut-sei=‰ª–{ kn-aut-mei=N”Ž aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=3 article-no= start-page=142 end-page=149 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=”ž”Á—tƒ‚ƒUƒCƒN•aŠ´õŽžŠú‚̃r[ƒ‹‘唞‚¨‚æ‚Ѭ”ž‚̾—Ê,ŽíŽq“`õ‚É‚¨‚æ‚Ú‚·‰e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆäã’‰’j kn-aut-sei=ˆäã kn-aut-mei=’‰’j aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{N”Ž kn-aut-sei=‰ª–{ kn-aut-mei=N”Ž aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼–å‹`ˆê kn-aut-sei=¼–å kn-aut-mei=‹`ˆê aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=3 article-no= start-page=129 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A•¨•aŒ´‹Û‚ɑ΂·‚éR‹Û•¨Ž¿‚ð¶ŽY‚·‚é”÷¶•¨‚Ì—˜—p‚ÉŠÖ‚·‚錤‹†@‘æ5•ñ@Streptomyces albus C 1-2Š”‚Ì“yë’†‚Å‚ÌImoticidin‚̶ŽY,‚¨‚æ‚ÑCorticium centrifugum‚ɑ΂·‚é“yë’†‚Å‚ÌImoticidin‚ÌŒø‰Ê en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆäã’‰’j kn-aut-sei=ˆäã kn-aut-mei=’‰’j aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{N”Ž kn-aut-sei=‰ª–{ kn-aut-mei=N”Ž aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼–å‹`ˆê kn-aut-sei=¼–å kn-aut-mei=‹`ˆê aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=3 article-no= start-page=120 end-page=128 dt-received= dt-revised= dt-accepted= dt-pub-year=1959 dt-pub=195902 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A•¨•aŒ´‹Û‚ɑ΂·‚éR‹Û•¨Ž¿‚ð¶ŽY‚·‚é”÷¶•¨‚Ì—˜—p‚ÉŠÖ‚·‚錤‹†@‘æ4•ñ@Streptomyces albus C 1-2Š”‚̶ŽY‚·‚éVR‹Û•¨Ž¿,Imoticidin‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆäã’‰’j kn-aut-sei=ˆäã kn-aut-mei=’‰’j aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{N”Ž kn-aut-sei=‰ª–{ kn-aut-mei=N”Ž aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼–å‹`ˆê kn-aut-sei=¼–å kn-aut-mei=‹`ˆê aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=46 cd-vols= no-issue=2 article-no= start-page=49 end-page=53 dt-received= dt-revised= dt-accepted= dt-pub-year=1958 dt-pub=195810 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒEƒƒ“Ž_‚Ì‘ãŽÓ‚ÉŠÖ‚·‚錤‹†i1j@Erwinia aroideae‚̃Eƒƒ“Ž_‘ãŽÓ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=1 article-no= start-page=1 end-page=4 dt-received= dt-revised= dt-accepted= dt-pub-year=1957 dt-pub=195708 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Erwinia aroideae‚Ì“œ‰»Œ^ƒ|ƒŠƒKƒ‰ƒNƒ`ƒ†ƒƒi[ƒ[‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=3 article-no= start-page=119 end-page=126 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=195612 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A•¨•aŒ´‹Û‚É›”‚·‚éR‹Û•¨Ž¿‚ð¶ŽY‚·‚é”÷¶•¨‚Ì—˜—p‚ÉŠÖ‚·‚é?‹†i‘æ3•ñj@“yšß‘ÎR–@‚É‚æ‚é2,3‚ÌŽÀŒ± en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼–å‹`ˆê kn-aut-sei=¼–å kn-aut-mei=‹`ˆê aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{N”Ž kn-aut-sei=‰ª–{ kn-aut-mei=N”Ž aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆäã’‰’j kn-aut-sei=ˆäã kn-aut-mei=’‰’j aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=2 article-no= start-page=81 end-page=85 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=195610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Erwinia‚̃yƒNƒ`ƒ“|ƒ|ƒŠƒKƒ‰ƒNƒ`ƒ†ƒƒi[ƒ[ŽY¶ðŒ‚ɂ‚¢‚Äi‘æ2•ñj@’Y‘fŒ¹‚̉e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=44 cd-vols= no-issue=1 article-no= start-page=34 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=195603 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Erwinia‚̃yƒNƒ`ƒ“|ƒ|ƒŠƒKƒ‰ƒNƒ`ƒ†ƒƒi[ƒ[ŽY¶ðŒ‚ɂ‚¢‚Ä@‚P–³‹@‰–—ނ̉e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=4 article-no= start-page=165 end-page=171 dt-received= dt-revised= dt-accepted= dt-pub-year=1956 dt-pub=19560320 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A•¨•aŒ´‹Û‚É›”‚·‚éR‹Û•¨Ž¿‚ð¶ŽY‚·‚é”÷¶•¨‚Ì—˜—p‚ÉŠÖ‚·‚é?‹†i‘æ2•ñj@–³ŽE‹Û“yšß‚Å”’Œ¦•a‹ÛCorticium centrifugum‚É—LŒø‚È‘ÎR•úü‹Û2Š” en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼–å‹`ˆê kn-aut-sei=¼–å kn-aut-mei=‹`ˆê aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆäã’‰’j kn-aut-sei=ˆäã kn-aut-mei=’‰’j aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{N”Ž kn-aut-sei=‰ª–{ kn-aut-mei=N”Ž aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=43 cd-vols= no-issue=2 article-no= start-page=63 end-page=72 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550620 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A•¨•aŒ´‹Û‚ɑ΂·‚éR‹Û•¨Ž¿‚ð¶ŽY‚·‚é”÷¶•¨‚Ì—˜—p‚ÉŠÖ‚·‚é?‹†iIj@Streptomyces sp. 30-10Š”‚Æ‚»‚ê‚̶ŽY‚·‚éRŽ…?‹Û•¨Ž¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼–å‹`ˆê kn-aut-sei=¼–å kn-aut-mei=‹`ˆê aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆäã’‰’j kn-aut-sei=ˆäã kn-aut-mei=’‰’j aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{N”Ž kn-aut-sei=‰ª–{ kn-aut-mei=N”Ž aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=4 article-no= start-page=143 end-page=150 dt-received= dt-revised= dt-accepted= dt-pub-year=1955 dt-pub=19550125 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒRƒ€ƒMÔƒJƒr•a‚Ì‘æ“ñŽŸ“`õ‚ɂ‚¢‚Ä@‘æ2•ñ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼–å‹`ˆê kn-aut-sei=¼–å kn-aut-mei=‹`ˆê aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=ˆäã’‰’j kn-aut-sei=ˆäã kn-aut-mei=’‰’j aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{N”Ž kn-aut-sei=‰ª–{ kn-aut-mei=N”Ž aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=4 article-no= start-page=157 end-page=161 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540227 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒyƒNƒ`ƒ“?y‚ÉA‚Ä@‘æ19•ñ@ƒyƒNƒ`ƒ“‚Ì•ª‰ð’†ŠÔ•¨‚ɑ΂·‚éƒ|ƒŠƒKƒ‰ƒNƒ`ƒ…ƒƒi[ƒ[‚Ìì—pi2j en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=3 article-no= start-page=128 end-page=130 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19540115 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒyƒNƒ`ƒ“?y‚ÉA‚Ä@‘æ18•ñ@ƒyƒNƒ`ƒ“‚Ì•ª‰ð’†ŠÔ•¨‚ɑ΂·‚éƒ|ƒŠƒKƒ‰ƒNƒ`ƒ…ƒƒi[ƒ[‚Ìì—pi1j en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=2 article-no= start-page=79 end-page=81 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530915 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒyƒNƒ`ƒ“?y‚ÉA‚Ä@‘æ17•ñ@Penicillium expansum‚Ì“œ‰»Œ^ƒ|ƒŠƒKƒ‰ƒNƒ`ƒ†ƒƒi[ƒ[ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=1 article-no= start-page=21 end-page=26 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒyƒNƒ`ƒ“?y‚ÉA‚Ä@‘æ16•ñ@ƒ|ƒŠƒKƒ‰ƒNƒ`ƒ…ƒƒi[ƒ[‚Ì“ÁˆÙ« en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=•“cW kn-aut-sei=•“c kn-aut-mei=W aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=41 cd-vols= no-issue=1 article-no= start-page=17 end-page=20 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ƒyƒNƒ`ƒ“?y‚ÉA‚Ä@‘æ15•ñ@ƒyƒNƒ`ƒ“Ž¿‚Ì•ª‰ð‚Æmaceration‚ÌŠÖŒWi6j en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¬‘ò“ñ˜Y kn-aut-sei=¬‘ò kn-aut-mei=“ñ˜Y aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œ«ˆê kn-aut-sei=‰ª–{ kn-aut-mei=Œ«ˆê aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=20 cd-vols= no-issue= article-no= start-page=377 end-page=421 dt-received= dt-revised= dt-accepted= dt-pub-year=1933 dt-pub=19330425 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=–{–M‚ɉ—‚¯‚éA•¨•aŠQ‚Éè‚·‚镶àÙ–Ú?iˆê‹ãŽO“ñj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼–å‹`ˆê kn-aut-sei=¼–å kn-aut-mei=‹`ˆê aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=¼–{O‹` kn-aut-sei=¼–{ kn-aut-mei=O‹` aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{•qˆê kn-aut-sei=‰ª–{ kn-aut-mei=•qˆê aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil= affil-num=2 en-affil= kn-affil= affil-num=3 en-affil= kn-affil= END start-ver=1.4 cd-journal=joma no-vol=125 cd-vols= no-issue=1 article-no= start-page=35 end-page=39 dt-received= dt-revised= dt-accepted= dt-pub-year=2013 dt-pub=20130401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=An epidemiologically rare case of Vibrio vulnificus infection that occurred in October in an inland city of Japan kn-title=“à—¤’n’ÃŽR‚Å”­Ç‚µ‚½‹GߊO‚ê‚ÌVibrio vulnificusŠ´õÇ en-subtitle= kn-subtitle= en-abstract= kn-abstract=@A 68-year-old man with alcohol addiction, who lived in the suburbs of Tsuyama, an inland city located in northeast Okayama prefecture, was transported to the emergency unit of the Tsuyama Central Hospital in a state of cardiopulmonary arrest (CPA). Despite rigorous systemic investigation and treatment, the patient died 2 hours after arrival. After his death, Vibrio vulnificus was isolated from his blood culture. @Vibrio vulnificus causes fatal infection in humans, usually only in areas located close to the sea where appropriate temperature and suitable salt concentration for its growth are available. Therefore, its occurrence is epidemiologically restricted ; in Japan, the western coastal areas, especially in summers, are reported to be the high-risk regions. This is a rare case because it occurred in a city approximately 50 kilometers from both the Sea of Japan and the Pacific coast of Okayama, and at the end of October in 2011. Economic development and distribution systems have made it possible to transport various food products from coastal areas or abroad to any place in a short time, such that these infections can potentially develop in areas other than expected. We should be aware of the increasing risk of Vibrio vulnificus infection during any season and at any place, especially in patients with abnormal liver function. en-copyright= kn-copyright= en-aut-name=HagiyaHideharu en-aut-sei=Hagiya en-aut-mei=Hideharu kn-aut-name=”‹’J‰p‘å kn-aut-sei=”‹’J kn-aut-mei=‰p‘å aut-affil-num=1 ORCID= en-aut-name=ShiotaSumiko en-aut-sei=Shiota en-aut-mei=Sumiko kn-aut-name=‰–“cŸŽq kn-aut-sei=‰–“c kn-aut-mei=ŸŽq aut-affil-num=2 ORCID= en-aut-name=MiyoshiShin-ichi en-aut-sei=Miyoshi en-aut-mei=Shin-ichi kn-aut-name=ŽODLˆê kn-aut-sei=ŽOD kn-aut-mei=Lˆê aut-affil-num=3 ORCID= en-aut-name=KuroeYasutoshi en-aut-sei=Kuroe en-aut-mei=Yasutoshi kn-aut-name=•]‘×—˜ kn-aut-sei=•] kn-aut-mei=‘×—˜ aut-affil-num=4 ORCID= en-aut-name=NojimaHiroyoshi en-aut-sei=Nojima en-aut-mei=Hiroyoshi kn-aut-name=–쓇G‰x kn-aut-sei=–쓇 kn-aut-mei=G‰x aut-affil-num=5 ORCID= en-aut-name=OtaniShinkichi en-aut-sei=Otani en-aut-mei=Shinkichi kn-aut-name=‘å’JW‹g kn-aut-sei=‘å’J kn-aut-mei=W‹g aut-affil-num=6 ORCID= en-aut-name=SugiyamaJunichi en-aut-sei=Sugiyama en-aut-mei=Junichi kn-aut-name=™ŽR~ˆê kn-aut-sei=™ŽR kn-aut-mei=~ˆê aut-affil-num=7 ORCID= en-aut-name=NaitoHiromichi en-aut-sei=Naito en-aut-mei=Hiromichi kn-aut-name=“à“¡G“¹ kn-aut-sei=“à“¡ kn-aut-mei=G“¹ aut-affil-num=8 ORCID= en-aut-name=KawanishiSusumu en-aut-sei=Kawanishi en-aut-mei=Susumu kn-aut-name=ì¼i kn-aut-sei=ì¼ kn-aut-mei=i aut-affil-num=9 ORCID= en-aut-name=HagiokaShingo en-aut-sei=Hagioka en-aut-mei=Shingo kn-aut-name=”‹‰ªMŒá kn-aut-sei=”‹‰ª kn-aut-mei=MŒá aut-affil-num=10 ORCID= en-aut-name=MorimotoNaoki en-aut-sei=Morimoto en-aut-mei=Naoki kn-aut-name=X–{’¼Ž÷ kn-aut-sei=X–{ kn-aut-mei=’¼Ž÷ aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=’ÃŽR’†‰›•a‰@@‹~–½‹~‹}ƒZƒ“ƒ^[ affil-num=2 en-affil= kn-affil=AŽÀ‘åŠw–òŠw•”@•aŒ´”÷¶•¨Šw affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@‰q¶”÷¶•¨‰»Šw affil-num=4 en-affil= kn-affil=’ÃŽR’†‰›•a‰@@‹~–½‹~‹}ƒZƒ“ƒ^[ affil-num=5 en-affil= kn-affil=’ÃŽR’†‰›•a‰@@‹~–½‹~‹}ƒZƒ“ƒ^[ affil-num=6 en-affil= kn-affil=’ÃŽR’†‰›•a‰@@‹~–½‹~‹}ƒZƒ“ƒ^[ affil-num=7 en-affil= kn-affil=’ÃŽR’†‰›•a‰@@‹~–½‹~‹}ƒZƒ“ƒ^[ affil-num=8 en-affil= kn-affil=’ÃŽR’†‰›•a‰@@‹~–½‹~‹}ƒZƒ“ƒ^[ affil-num=9 en-affil= kn-affil=’ÃŽR’†‰›•a‰@@‹~–½‹~‹}ƒZƒ“ƒ^[ affil-num=10 en-affil= kn-affil=’ÃŽR’†‰›•a‰@@‹~–½‹~‹}ƒZƒ“ƒ^[ affil-num=11 en-affil= kn-affil=’ÃŽR’†‰›•a‰@@‹~–½‹~‹}ƒZƒ“ƒ^[ en-keyword=Vibrio vulnificus kn-keyword=Vibrio vulnificus END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=145 end-page=148 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of esophageal carcinosarcoma with a component of small cell carcinoma kn-title=¬×–EŠà¬•ª‚ðŠÜ‚ÞH“¹Šà“÷Žî‚Ì‚PØœ—á en-subtitle= kn-subtitle= en-abstract= kn-abstract=We experienced a case of esophageal carcinosarcoma with a component of small cell carcinoma. The patient was a 73-year-old man. We administered chemotherapy of CDDP+VP-16, and performed an operation after 2 courses of this chemotherapy. Subtotal esophagectomy and reconstruction with the small intestine was performed. More than three years after resection, he remains alive and recurrence-free. There are few cases of esophageal carcinosarcoma and small cell carcinoma. We report this rare case herein. en-copyright= kn-copyright= en-aut-name=TanabeShunsuke en-aut-sei=Tanabe en-aut-mei=Shunsuke kn-aut-name=“c•Ór‰î kn-aut-sei=“c•Ó kn-aut-mei=r‰î aut-affil-num=1 ORCID= en-aut-name=ShirakawaYasuhiro en-aut-sei=Shirakawa en-aut-mei=Yasuhiro kn-aut-name=”’ì–õ”Ž kn-aut-sei=”’ì kn-aut-mei=–õ”Ž aut-affil-num=2 ORCID= en-aut-name=MaedaNaoaki en-aut-sei=Maeda en-aut-mei=Naoaki kn-aut-name=‘O“c’¼Œ© kn-aut-sei=‘O“c kn-aut-mei=’¼Œ© aut-affil-num=3 ORCID= en-aut-name=OharaToshiaki en-aut-sei=Ohara en-aut-mei=Toshiaki kn-aut-name=‘匴—˜Í kn-aut-sei=‘匴 kn-aut-mei=—˜Í aut-affil-num=4 ORCID= en-aut-name=NomaKazuhiro en-aut-sei=Noma en-aut-mei=Kazuhiro kn-aut-name=–ìŠÔ˜aL kn-aut-sei=–ìŠÔ kn-aut-mei=˜aL aut-affil-num=5 ORCID= en-aut-name=SakuramaKazufumi en-aut-sei=Sakurama en-aut-mei=Kazufumi kn-aut-name=ŸNŠÔ‹³•¶ kn-aut-sei=ŸNŠÔ kn-aut-mei=‹³•¶ aut-affil-num=6 ORCID= en-aut-name=YanaiHiroyuki en-aut-sei=Yanai en-aut-mei=Hiroyuki kn-aut-name=–öˆäL”V kn-aut-sei=–öˆä kn-aut-mei=L”V aut-affil-num=7 ORCID= en-aut-name=YamatsujiTomoki en-aut-sei=Yamatsuji en-aut-mei=Tomoki kn-aut-name=ŽR’Ò’mŽ÷ kn-aut-sei=ŽR’Ò kn-aut-mei=’mŽ÷ aut-affil-num=8 ORCID= en-aut-name=NaomotoYoshio en-aut-sei=Naomoto en-aut-mei=Yoshio kn-aut-name=—P–{—Ç•v kn-aut-sei=—P–{ kn-aut-mei=—Ç•v aut-affil-num=9 ORCID= en-aut-name=FujiwaraToshiyoshi en-aut-sei=Fujiwara en-aut-mei=Toshiyoshi kn-aut-name=“¡Œ´r‹` kn-aut-sei=“¡Œ´ kn-aut-mei=r‹` aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@•a—f’f‰È affil-num=8 en-affil= kn-affil=ìèˆã‰È‘åŠw@‘‡ŠO‰ÈŠw affil-num=9 en-affil= kn-affil=ìèˆã‰È‘åŠw@‘‡ŠO‰ÈŠw affil-num=10 en-affil= kn-affil=‰ªŽR‘åŠw•a‰@@Á‰»ŠÇŠO‰È en-keyword=H“¹Šà“÷Žîiesophageal carcinosarcomaj kn-keyword=H“¹Šà“÷Žîiesophageal carcinosarcomaj en-keyword=¬×–EŠàismall cell carcinomaj kn-keyword=¬×–EŠàismall cell carcinomaj en-keyword=H“¹iesophagusj kn-keyword=H“¹iesophagusj END start-ver=1.4 cd-journal=joma no-vol=124 cd-vols= no-issue=2 article-no= start-page=129 end-page=136 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=20120801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Antibacterial efficacy of photocatalytic reaction on titanium dioxide-coated ceramic air filters kn-title=Ž_‰»ƒ`ƒ^ƒ“’SŽƒZƒ‰ƒ~ƒbƒNƒtƒBƒ‹ƒ^[‚ÌŒõG”}”½‰ž‚É‚æ‚éR‹ÛŒø‰Ê‚ÌŒŸ“¢ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Titanium dioxide (TiO2) photocatalysis generates reactive oxygen species such as EOH and EO2-, which can effectively eliminate organic compounds. In the present study, we evaluated the antibacterial and antifungal effects of TiO2-coated ceramic air filters in both laboratory and hospital settings. Photocatalysis with the TiO2-coated ceramic filter effectively inactivated all 4 pathogenic organisms tested. Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Candida albicans. After the photocatalysis reaction for 4 h under UV-A (365nm, 250ƒÊW/?) irradiation, the percentage reductions of the number of E. coli, P. aeruginosa, S. aureus, C. albicans cells were 99.9%, 98.9%, 97.7% and 99.9%, respectively, indicating that Gram-negative bacteria are more susceptible to such photocatalysis than Gram-positive bacteria. Scanning electron microscopic analysis showed damage to the cytoplasmic membrane and cell wall by photocatalysis : consistent with above observations, the morphological change of Gram-negative E. coli was greater than that of Gram-positive S. aureus. @Further, an air cleaner equipped with a TiO2-coated ceramic filter significantly decreased the number of bacteria floating in hospitals. @These results indicate that air cleaners with TiO2-coated ceramic filters could be useful in reducing the incidence of nosocomial infections. en-copyright= kn-copyright= en-aut-name=NakaoMiyuki en-aut-sei=Nakao en-aut-mei=Miyuki kn-aut-name=’†”ö”üK kn-aut-sei=’†”ö kn-aut-mei=”üK aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŽ•–òŠw‘‡Œ¤‹†‰È@•aŒ´×‹ÛŠw en-keyword=ŒõG”}iphotocatalysisj kn-keyword=ŒõG”}iphotocatalysisj en-keyword=Ž_‰»ƒ`ƒ^ƒ“’SŽƒZƒ‰ƒ~ƒbƒNƒtƒBƒ‹ƒ^[iTiO2-coated ceramic air filtersj kn-keyword=Ž_‰»ƒ`ƒ^ƒ“’SŽƒZƒ‰ƒ~ƒbƒNƒtƒBƒ‹ƒ^[iTiO2-coated ceramic air filtersj en-keyword=R‹ÛŒø‰Êiantimicrobial effectj kn-keyword=R‹ÛŒø‰Êiantimicrobial effectj en-keyword=‰@“àŠ´õinosocomial infectionj kn-keyword=‰@“àŠ´õinosocomial infectionj en-keyword=‹ó‹C´ò‹@iair cleanerj kn-keyword=‹ó‹C´ò‹@iair cleanerj END start-ver=1.4 cd-journal=joma no-vol=2 cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100605 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Emerging trends in the etiology of enteric pathogens as evidenced from an active surveillance of hospitalized diarrhoeal patients in Kolkata, India en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: This study was conducted to determine the etiology of diarrhoea in a hospital setting in Kolkata. Active surveillance was conducted for 2 years on two random days per week by enrolling every fifth diarrhoeal patient admitted to the Infectious Diseases and Beliaghata General Hospital in Kolkata. Results: Most of the patients (76.1%) had acute watery diarrhoea in association with vomiting (77.7%) and some dehydration (92%). Vibrio cholerae O1, Rotavirus and Giardia lamblia were the important causes of diarrhoea. Among Shigella spp, S. flexneri 2a and 3a serotypes were most predominantly isolated. Enteric viruses, EPEC and EAEC were common in children <5 year age group. Atypical EPEC was comparatively higher than the typical EPEC. Multidrug resistance was common among V. cholerae O1 and Shigella spp including tetracycline and ciprofloxacin. Polymicrobial infections were common in all age groups and 27.9% of the diarrhoea patients had no potential pathogen. Conclusions: Increase in V. cholerae O1 infection among <2 years age group, resistance of V. cholerae O1 to tetracycline, rise of untypable S. flexnerii, higher proportion of atypical EPEC and G. lamblia and polymicrobial etiology are some of the emerging trends observed in this diarrhoeal disease surveillance. en-copyright= kn-copyright= en-aut-name=NairGopinath Balakrish en-aut-sei=Nair en-aut-mei=Gopinath Balakrish kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=RamamurthyThandavarayan en-aut-sei=Ramamurthy en-aut-mei=Thandavarayan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=BhattacharyaMihir Kumar en-aut-sei=Bhattacharya en-aut-mei=Mihir Kumar kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KrishnanTriveni en-aut-sei=Krishnan en-aut-mei=Triveni kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=GangulySandipan en-aut-sei=Ganguly en-aut-mei=Sandipan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=SahaDhira Rani en-aut-sei=Saha en-aut-mei=Dhira Rani kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=RajendranKrishnan en-aut-sei=Rajendran en-aut-mei=Krishnan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=MannaByomkesh en-aut-sei=Manna en-aut-mei=Byomkesh kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=GhoshMrinmoy en-aut-sei=Ghosh en-aut-mei=Mrinmoy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=TakedaYoshifumi en-aut-sei=Takeda en-aut-mei=Yoshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=2 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=3 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=4 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=5 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=6 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=7 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=8 en-affil= kn-affil=National Institute of Cholera and Enteric Diseases (NICED) affil-num=9 en-affil= kn-affil=Infectious Diseases and Beliaghata General Hospital affil-num=10 en-affil= kn-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University affil-num=11 en-affil= kn-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India, NICED END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=2 article-no= start-page=143 end-page=154 dt-received= dt-revised= dt-accepted= dt-pub-year=2012 dt-pub=201204 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Attenuated Sensory Deprivation-induced Changes of Parvalbumin Neuron Density in the Barrel Cortex of FcƒÁRllB-deficient Mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of FcƒÁRllB protein in parvalbumin- containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in FcƒÁRllB-deficient mice (FcƒÁRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between FcƒÁRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcƒÁRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcƒÁRllB contributes to sensory experience-regulated expression of PV. en-copyright= kn-copyright= en-aut-name=WatanabeMakiko en-aut-sei=Watanabe en-aut-mei=Makiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UenoHiroshi en-aut-sei=Ueno en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=SuemitsuShunsuke en-aut-sei=Suemitsu en-aut-mei=Shunsuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=YokobayashiEriko en-aut-sei=Yokobayashi en-aut-mei=Eriko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=MatsumotoYosuke en-aut-sei=Matsumoto en-aut-mei=Yosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UsuiShinichi en-aut-sei=Usui en-aut-mei=Shinichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SujiuraHiroko en-aut-sei=Sujiura en-aut-mei=Hiroko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=2 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=3 en-affil= kn-affil=Koyodai Hospital affil-num=4 en-affil= kn-affil=Department of Psychiatry, Kawasaki Medical University affil-num=5 en-affil= kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=7 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University affil-num=8 en-affil= kn-affil=Department of Medical Technology, Graduate School of Health Sciences, Okayama University en-keyword=parvalbumin kn-keyword=parvalbumin en-keyword=fast-spiking interneurons kn-keyword=fast-spiking interneurons en-keyword=FcƒÁRllB kn-keyword=FcƒÁRllB en-keyword=barrel cortex kn-keyword=barrel cortex en-keyword=sensory deprivation kn-keyword=sensory deprivation END start-ver=1.4 cd-journal=joma no-vol=147 cd-vols= no-issue= article-no= start-page=63 end-page=67 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110625 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research trends concerning school children's change of eating behavior during school lunches and their formation of sense of eating with company kn-title=ŠwZ‹‹H‚É‚¨‚¯‚鎙“¶‚ÌHs“®‚Ì•Ï—e‚ÆHŽ–ŠÏ‚ÌŒ`¬‚ÉŠÖ‚·‚錤‹†“®Œü en-subtitle= kn-subtitle= en-abstract= kn-abstract=–{e‚Ì–Ú“I‚ÍCŠwZ‹‹H‚Ì‹@”\‚É’…–Ú‚µCŽ™“¶‚ÌHs“®‚âHŽ–ŠÏ‚ÌŒ`¬‚ɉe‹¿‚ð—^‚¦‚é—vˆö‚ɂ‚¢‚Ä‚ÌŒ¤‹†“®Œü‚ð‚Ü‚Æ‚ßCŒ»‘ã‚É‚¨‚¯‚颋¤H£‚ð–ÚŽw‚µ‚½‹‹HŽw“±‚Ì—¯ˆÓ“_‚𖾂炩‚É‚·‚邱‚Æ‚Å‚ ‚éBæsŒ¤‹†‚ÍŽŸ‚ÌŽO‚‚ɕª—Þ¥®—‚µ‚½Bˆê‚‚߂ÍCŽ™“¶‚Ì‹‹HŽw“±‚ð’S‚¤‹³Žt‚̉e‹¿‚ð’T‹†‚µ‚½‚à‚Ì‚Å‚ ‚éB“ñ‚‚߂ÍCŽ™“¶‚Ì”­’B’iŠK‚̉e‹¿‚𒲸‚µ‚½‚à‚Ì‚ÅCŽO‚–ڂÍHŠÂ‹«‚̉e‹¿‚ÉÅ“_‚ð“–‚Ä‚½‚à‚Ì‚Å‚ ‚éBæsŒ¤‹†‚Ì“®Œü‚©‚ç–¾‚ç‚©‚É‚È‚Á‚½‚±‚Æ‚ÍC“ñ“_‚ ‚éBˆê“_–Ú‚ÍCŽ™“¶‚ÌHŽ–‚ɑ΂·‚éˆÓŽ¯‚𑨂¦‚éꇂ͒²¸•[‚ð—p‚¢‚½—Ê“I’²¸‚ðCŽ™“¶‚ÌHs“®‚Ì•Ï—e‚ð’Ç‹†‚·‚éꇂ͎¿“I’²¸‚ðŠeŒ¤‹†ŽÒ‚ª—˜—p‚µ‚Ä‚¢‚½‚±‚Æ‚Å‚ ‚éB“ñ“_–Ú‚ÍCŽ™“¶‚ÌHŽ–ŠÏ‚͉ƒ낾‚¯‚Å‚È‚­‹‹H‚É‚¨‚¢‚Ä‚à—lX‚ȉe‹¿‚ðŽó‚¯CŒ`¬‚³‚ê‚é‚Æ‚¢‚¤‚±‚Æ‚Å‚ ‚éB‚µ‚½‚ª‚Á‚ÄC‹³Žt‚⌤‹†ŽÒ‚ÍC¢‹¤H£‚ð–ÚŽw‚µ‚½‹‹HŽw“±‚ÉCŽ™“¶‚̎Љ‚𑣂·–ðŠ„‚ªŠÜ‚Ü‚ê‚Ä‚¢‚é‚Æ‚¢‚¤‚±‚Æ‚ð”FŽ¯‚·‚é•K—v‚ª‚ ‚éB en-copyright= kn-copyright= en-aut-name=NobeMasao en-aut-sei=Nobe en-aut-mei=Masao kn-aut-name=–ìç²­—Y kn-aut-sei=–ìç² kn-aut-mei=­—Y aut-affil-num=1 ORCID= en-aut-name=OkamotoMai en-aut-sei=Okamoto en-aut-mei=Mai kn-aut-name=‰ª–{^ˆË kn-aut-sei=‰ª–{ kn-aut-mei=^ˆË aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰ÈŽÐ‰ï¥Œ¾Œê‹³ˆçŠwŒnŽÐ‰ï‰È‹³ˆçuÀ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@‹³ˆçŠwŒ¤‹†‰È en-keyword=ŠwZ‹‹H kn-keyword=ŠwZ‹‹H en-keyword=‹¤H kn-keyword=‹¤H en-keyword=Ž™“¶ kn-keyword=Ž™“¶ en-keyword=Hs“® kn-keyword=Hs“® en-keyword=HŽ–ŠÏ kn-keyword=HŽ–ŠÏ END start-ver=1.4 cd-journal=joma no-vol=93 cd-vols= no-issue=1-2 suppl article-no= start-page=9 end-page=18 dt-received= dt-revised= dt-accepted= dt-pub-year=1981 dt-pub=19810228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Seasonal level of hemoagglutinin inhibitinlt and its 2-mercaptoethanol sensitive antibody in the sera of swine (Epidemiological Study on Japanese Encephalitis, 67) kn-title=“Ø‹y‚ÑZ–¯‚Ì“ú–{”]‰ŠHIR‘Ì‚¨‚æ‚Ñ2-MEŠ´Žó«R‘Ì—z«—¦ i“ú–{”]‰Š‚̉uŠw“IŒ¤‹† 67j en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seasonal level of hemoagglutinin inhibiting and its 2 -mercaptoethanol sensitive antibody in the sera of swine were researched and the following results were obtained. 1. The positive rate of hemoagglutination inhibit reaction (HI reaction) on swine showed 100% at maximum in the middle of September. 1980. The positive rate of 2-ME sensitive antibody showed the titer of over 1 : 40 with all swine examined in the middle of August, 1980. 2. The positive rate of HI reaction of inhabitants at Mukaiyama in Kurashiki City was 76.0% (on 8th in July, 1980) indicating the rather big decrease being compared with annual value of 90.6%, in 1976. Date indicated that increase In JE virus in swine as source of infection thought to be a vector of JE, caused a genuine case of JE, in 1980, as described below. 3. Higher positive rate of HI reaction and 2-ME sensitive positive rate of swine were observed in 1980. 4. One patient who suffered from JE was found In Kurashiki City in 1980. 5. Henceforth and continuously, Japanese Encephalitis should be investigated, above all on its occurance order with the number or Ct or the positive rate of hemoagglutination inhibit reaction in inhahitants and swine, etc. considering that J.E. has a high lethality rate and often leaves the terrible J. E. residue to patients. en-copyright= kn-copyright= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=•û³–¼ kn-aut-sei=•û kn-aut-mei=³–¼ aut-affil-num=1 ORCID= en-aut-name=MeguroTadamichi en-aut-sei=Meguro en-aut-mei=Tadamichi kn-aut-name=–Ú•’‰“¹ kn-aut-sei=–Ú• kn-aut-mei=’‰“¹ aut-affil-num=2 ORCID= en-aut-name=HirotaNoboru en-aut-sei=Hirota en-aut-mei=Noboru kn-aut-name=L“c¸ kn-aut-sei=L“c kn-aut-mei=¸ aut-affil-num=3 ORCID= en-aut-name=MatuiYoshinori en-aut-sei=Matui en-aut-mei=Yoshinori kn-aut-name=¼ˆä‹`“T kn-aut-sei=¼ˆä kn-aut-mei=‹`“T aut-affil-num=4 ORCID= en-aut-name=SatoYukinori en-aut-sei=Sato en-aut-mei=Yukinori kn-aut-name=²“¡ª‹I kn-aut-sei=²“¡ kn-aut-mei=ª‹I aut-affil-num=5 ORCID= en-aut-name=AikoHiromi en-aut-sei=Aiko en-aut-mei=Hiromi kn-aut-name=ˆ¤b”Ž”ü kn-aut-sei=ˆ¤b kn-aut-mei=”Ž”ü aut-affil-num=6 ORCID= en-aut-name=IshidaTatsuo en-aut-sei=Ishida en-aut-mei=Tatsuo kn-aut-name=Γc—§•v kn-aut-sei=Γc kn-aut-mei=—§•v aut-affil-num=7 ORCID= en-aut-name=HiramatsuMuneshige en-aut-sei=Hiramatsu en-aut-mei=Muneshige kn-aut-name=•½¼@¬ kn-aut-sei=•½¼ kn-aut-mei=@¬ aut-affil-num=8 ORCID= en-aut-name=OtokuraTakashi en-aut-sei=Otokura en-aut-mei=Takashi kn-aut-name=‰³‘q›Ù kn-aut-sei=‰³‘q kn-aut-mei=›Ù aut-affil-num=9 ORCID= en-aut-name=TakagiKanji en-aut-sei=Takagi en-aut-mei=Kanji kn-aut-name=‚–ØŠ°Ž¡ kn-aut-sei=‚–Ø kn-aut-mei=Š°Ž¡ aut-affil-num=10 ORCID= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name=‰ª–{ˆ® kn-aut-sei=‰ª–{ kn-aut-mei=ˆ® aut-affil-num=11 ORCID= en-aut-name=NishuTakeo en-aut-sei=Nishu en-aut-mei=Takeo kn-aut-name=“ñ@‘s•v kn-aut-sei=“ñ@ kn-aut-mei=‘s•v aut-affil-num=12 ORCID= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=Šp“ìd•v kn-aut-sei=Šp“ì kn-aut-mei=d•v aut-affil-num=13 ORCID= en-aut-name=JitsunariFumihiko en-aut-sei=Jitsunari en-aut-mei=Fumihiko kn-aut-name=ŽÀ¬•¶•F kn-aut-sei=ŽÀ¬ kn-aut-mei=•¶•F aut-affil-num=14 ORCID= en-aut-name=MorishitaTakayuki en-aut-sei=Morishita en-aut-mei=Takayuki kn-aut-name=X‰º‹ª”V kn-aut-sei=X‰º kn-aut-mei=‹ª”V aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒöO‰q¶Šw‹³Žº affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒöO‰q¶Šw‹³Žº affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒöO‰q¶Šw‹³Žº affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒöO‰q¶Šw‹³Žº affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒöO‰q¶Šw‹³Žº affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒöO‰q¶Šw‹³Žº affil-num=7 en-affil= kn-affil=‰ªŽRŒ§ŠÂ‹«•ÛŒ’ƒZƒ“ƒ^[ affil-num=8 en-affil= kn-affil=‰ªŽRŒ§ŠÂ‹«•ÛŒ’ƒZƒ“ƒ^[ affil-num=9 en-affil= kn-affil=‰ªŽR•ÛŒ’Š affil-num=10 en-affil= kn-affil=‰ªŽRŒ§‰q¶•” affil-num=11 en-affil= kn-affil=‰ªŽRŒ§‰q¶•” affil-num=12 en-affil= kn-affil=‰ªŽRŒ§‰q¶•” affil-num=13 en-affil= kn-affil=ìèˆã‰È‘åŠwEŒöO‰q¶Šw‹³Žº affil-num=14 en-affil= kn-affil=‰ªŽR‘åŠw‹³ˆçŠw•”E—{Œì‹³ˆç affil-num=15 en-affil= kn-affil=X‰º•a‰@ END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=2 article-no= start-page=129 end-page=132 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110801 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Laparoscopic surgery for mesenteric Castleman's disease kn-title=• o‹¾‰º‚É“Eo‚µ‚¦‚½ãsŒ‹’°ŠÔ–Œ”­¶‚ÌCastleman•a‚Ì‚P—á en-subtitle= kn-subtitle= en-abstract= kn-abstract=We report herein a case of mesenteric Castleman's disease which was confirmed on pathology. A 60-year-old man was admitted to our hospital complaining of abdominal pain. On the physical examination, there was no palpable mass. Computed tomography findings and magnetic resonance imaging revealed a well circumscribed, lobulated round mass on the right side of the superior mesenteric vein. Laparoscopic surgery for the mesenteric tumor was carried out to obtain a definite diagnosis and treatment. In the operative field, the mass was located on the ascending colic mesentery and measured about 3 cm in size. It was solid and surrounded by a thin fibrous capsule. The histological diagnosis of the mesenteric tumor was hyaline vascular type Castleman's disease. The postoperative course of the patient was uneventful, and he was discharged on the 10th postoperative day. en-copyright= kn-copyright= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=¼]Šw kn-aut-sei=¼] kn-aut-mei=Šw aut-affil-num=1 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=‘å’Ë^Æ kn-aut-sei=‘å’Ë kn-aut-mei=^Æ aut-affil-num=2 ORCID= en-aut-name=TomodaJun en-aut-sei=Tomoda en-aut-mei=Jun kn-aut-name=—F“cƒ kn-aut-sei=—F“c kn-aut-mei=ƒ aut-affil-num=3 ORCID= en-aut-name=FujiwaraKeishi en-aut-sei=Fujiwara en-aut-mei=Keishi kn-aut-name=“¡Œ´ŒhŽm kn-aut-sei=“¡Œ´ kn-aut-mei=ŒhŽm aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=2 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=3 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@“à‰È affil-num=4 en-affil= kn-affil=Œõ¶•a‰@@“à‰È en-keyword=Œ‹’°ŠÔ–Œ (mesocolon) kn-keyword=Œ‹’°ŠÔ–Œ (mesocolon) en-keyword=Castleman•a (Castleman's disease) kn-keyword=Castleman•a (Castleman's disease) en-keyword=• o‹¾Žèp (laparoscopic surgery) kn-keyword=• o‹¾Žèp (laparoscopic surgery) END start-ver=1.4 cd-journal=joma no-vol=123 cd-vols= no-issue=1 article-no= start-page=33 end-page=38 dt-received= dt-revised= dt-accepted= dt-pub-year=2011 dt-pub=20110401 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Investigation of laparoscopic therapy in 56 cases of duodenal ulcer perforation kn-title=\“ñŽw’°’×á‡úE‚ɑ΂·‚鎡—Ö@‚Ì“K‰ž‚ɂ‚¢‚Ä‚ÌŒŸ“¢ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Background: Although conservative therapy has been acceptable as the first-line therapy for duodenal ulcer (DU) perforations, surgical therapies are known to have certain advantages. We investigated the indications for laparoscopic (LS) or open surgery (OS) or conservative therapy (CoT) among 56 DU perforation cases over 5 years. Methods: 31 LSs, 22 OSs and 5 CoTs were analyzed for patient's physical and surgical factors and clinical course. Results: Mean age was 51.6. Male/female ratio was 49/9. Survival ratio was 98%. Although the hospital stay (10.9 vs 19.5 days) and analgesic administrations (1.9 vs 4.6 days) were significantly shorter in LS than OS, almost all OS patients were in serious condition as evidenced by longer waiting time before treatment, stronger pain, bigger hole of perforation, more ascites accumulation and higher morbidity of complications. Two cases of multisurgery were experienced in both LS and OS groups due to leakage of seam, abscess formation, relapsed ulcer or idiopathic intestinal perforation. LS is a therapy more widely usable and more beneficial than the other two. Conclusion: LS, a minimally invasive surgery for DU perforation, should be considered as a first-line standard therapy because of significant advantages such as shorter hospital stay. OS or CoT may be selected when appropriate. en-copyright= kn-copyright= en-aut-name=IshidoNobuhiro en-aut-sei=Ishido en-aut-mei=Nobuhiro kn-aut-name=Γ°“WG kn-aut-sei=Γ° kn-aut-mei=“WG aut-affil-num=1 ORCID= en-aut-name=TamuraRyuji en-aut-sei=Tamura en-aut-mei=Ryuji kn-aut-name=“c‘º—³“ñ kn-aut-sei=“c‘º kn-aut-mei=—³“ñ aut-affil-num=2 ORCID= en-aut-name=OkamotoTakahiro en-aut-sei=Okamoto en-aut-mei=Takahiro kn-aut-name=‰ª–{‹M‘å kn-aut-sei=‰ª–{ kn-aut-mei=‹M‘å aut-affil-num=3 ORCID= en-aut-name=KadowakiYoshihiko en-aut-sei=Kadowaki en-aut-mei=Yoshihiko kn-aut-name=–å˜e‰Ã•F kn-aut-sei=–å˜e kn-aut-mei=‰Ã•F aut-affil-num=4 ORCID= en-aut-name=MoriTakashi en-aut-sei=Mori en-aut-mei=Takashi kn-aut-name=X—² kn-aut-sei=X kn-aut-mei=—² aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=_ŒËÔ\Žš•a‰@@ŠO‰È affil-num=2 en-affil= kn-affil=_ŒËÔ\Žš•a‰@@ŠO‰È affil-num=3 en-affil= kn-affil=_ŒËÔ\Žš•a‰@@ŠO‰È affil-num=4 en-affil= kn-affil=_ŒËÔ\Žš•a‰@@ŠO‰È affil-num=5 en-affil= kn-affil=_ŒËÔ\Žš•a‰@@ŠO‰È en-keyword=\“ñŽw’°’×á‡úE (duodenal ulcer perforation) kn-keyword=\“ñŽw’°’×á‡úE (duodenal ulcer perforation) en-keyword=• o‹¾Žèp (laparoscopic surgery) kn-keyword=• o‹¾Žèp (laparoscopic surgery) en-keyword=•Û‘¶—Ö@ (conservative therapy) kn-keyword=•Û‘¶—Ö@ (conservative therapy) END start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=3 article-no= start-page=496 end-page=503 dt-received= dt-revised= dt-accepted= dt-pub-year=1942 dt-pub=19420331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber einen Fall von Brustdr?senkarzinom' bei m?nnlichem Geschlecht und eine statistische Beobachtnng des Brustdr?senkarzinoms bei M?nnern in Japan kn-title=’jŽq“ûŠàƒm1—á‹yƒr–{–M’jŽq“ûŠàƒm“Œv“IæVŽ@ en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) Verf. berichtet ?ber einen Fall von rechtsseitigen ulcer?sem Brustdr?senkarzinom (Carcinoma simplex) bei einem 62 j?hrigen Manne. 2) Das Mammakarzinom ist bei M?nnern eine ?usserst seltene Erscheinung, unter den s?mtliehen 80 F?llen des Brustdr?senkarzinoms welche im Laufe der letzten 10 Jahre in unserer Tsuda-Klinik behandelt wordcn waren, war nur ein Fall bei m?nniichem Geschlecht vorgekommen, das macht also 1,25% aller Mammakarzinome unserer Klinik aus. Auch nach manchen, spezifisch klinischen Statisken weist es eine Frequenz von ca. 1% der ganzen Mammakarzinome auf. 3) Aus der einheimischen Literatur hat der Verf. insgesamt 34 zuverl?ssige F?lle von m?nnlichem Mammakarzinom ausgew?hlt und daren eine statistische Beobachtung angestellt. 4) Das vorliegende Karzinom entwickelt sich bei M?nnern in der Regel 5-10 Jahre sp?ter als bei Frauen und am h?ufigsten im 50., durchschnittlich im 56,6 Jahr. 5) Die befallene Seite der Mamma wurde in ann?hernd gleicher H?ufigkeit nachgewiesen. 6) Die Frist von der Entstehung der Tumoren bis zur Operation betrug in 8 F?llen l?nger als 2 Jahre und darunter, in 19 F?llen l?ager als 2 Jahre, in den ?brigen 8 F?llen war sie nicht bekannt. 7) ?ber die Pathogenese ist noch keine Einheit erzielt. Es interessiert uns aber, dass es viele F?lle gab, in denen wir einen ?bergang des benignen zum malignen Tumor annehmen m?ssen. 8) Das Karzinom nahm seinen Sitz in den meisten F?llen im zentralen Abschnitt der Mamma ein und war meistens h?hnerei- resp. faustgross. Geschw?rsbildung liess sich bei 46% der F?lle feststellen. 9) Was die histopathologischen Befunde anbetrifft, so wurde Adenokarzinom am h?ufigsten, d.h. in den 11 F?llen (36,6%) beobachtet, ihm folgte der Skirrhus mit 8 F?llen (26,6%). en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=‰ª–{”É kn-aut-sei=‰ª–{ kn-aut-mei=”É aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRçΉȑå›{’ÓcŠO‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=4 article-no= start-page=596 end-page=612 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=?ber die primare Lungen- und Periproktalaktinomykose kn-title=Œ´á¢«”x•úüó‹ÛÇâƒj•úüó‹Û«ãè–åŽüš¡”^ᇃjAƒe en-subtitle= kn-subtitle= en-abstract= kn-abstract=1) Ein 22 j?hriger Seemann. Seitdem er im Mai 1938 dem Stellungsbefehl Folge geleistet hatte, arbeitete er auf einem von der Regierung gecharterten Schiff an der Abladung der Milit?rpferde und f?hrte so von Tag zu Tag unsauberes Leben. Im September verliess er wegen Beriberi das Schiff und wurde in ein Krankenhaus aufgenommen. Von dem n?chsten Tage an trat ein heftiger Schmerz am unteren Teil des Prozessus Xyphoideus ein. Zu dieser Zeit hatte er Husten und entleerte Sputa, wovon er sich jedoch gar nicht bek?mmerte. Am Vorderthorax nahmen indes R?tung der Haut, Schwellung und Schmerz allm?hlich an St?rke zu, am Ende desselben Jahres entstanden schliesslich Fisteln, woraus dickfl?ssige Eiter herauskamen. Im Anfang des nachsten Jahres wurde er in einem Krankenhause unter der auf R?ntgenbild gestellten Diagnose als eine Lungentuberkulose behandelt. Da es sich aber immer weiter verschlimmert hatte, wurde er schliesslich im M?rz 1939 mit den Hauptklagen ?ber zahlreiche Fistelbildun gen an der vorderen Thoraxwand und einen heftigen Schmerz im Thorax in unsere Klinik eingeliefert. Die sehr charakteristischen Drusen oder die Tuberkelbazillen liessen sich nicht im Sputum, sondern die Drusen in der Eiterfl?ssigkeit nachweisen. Auf Grund der Reinkultur wurde es ferner festgestellt, dass die aufgefundenen Strahlenpilzen zu einer Art der fakultativen Anaerobien geh?rten. Im Anchluss an diesen Befund sprachen die Befunde der R?ntgenuntersuchung der Thoraxgegend daf?r, dass es sich um eine prim?re Lungenaktinomykose handelte, weiche die Partie von der rechten Lungenpforte bis zum Unterlappen angriff. Der Verf. berichtet ?ber die vollige Heilung des Kranken, die er durch Inzision der Abezesse, Auskratzung, Aufstreuung von Jodformpulvern, fortgesetzte Darreichung gr?sserer Dosen von Jodkalium (bis zu 6g), Injektion von Aktisol, R?ntgenbestrahlung (Abstand: 30cm, 150ƒÁ; Intervall: 3 Tage-1 Woche; im Laufe von 58 Tagen 12mal bestrahlt) erzielen konnte. Schliesslich f?gt er noch Besprechung ?ber dieses Krankneitsbild hinzu. Die vorliegende Krankheit bevorzugt gerade wie der andersartigen Aktinomykosen junge M?nner von 20-30 Jahren (befallen wurden die M?nner ca. 2 oder 3 fach mehr als die Frauen) und zwar entwickelt sich am h?ufigsten am rechten Unterlappen. Verhaltnism?ssig selten iet Lungenaktinomykose: sie betr?gt in der Frequenz nur 15-20% der gesammten F?lle. Der Verf. hebt besonders hervor, dass man bei der Stellung der Differenzialdiagnose gegen die Lungentuberkulose sehr vorsichtig sein soil. R?ntgenologisch bietet die Luugenaktinomykose keinen eigent?mlichen Schatten dar, im Vergleich zur Lungentuberkulose treten jedoch bei ihr ziemlich derbe und dicke Schatten, welche von Peribronchitis herr?hren, in die Erscheinung. Ausserdem kann man bei aufmerksamer Beobachtung auch das Bild einer im Fr?stadium auftretenden Verdickung der Pleura, das Bild einer sich rapid und hochgradig einstellenden retraktiven Schrumpfung der Brusth?hle und das der Ossifikationsperiostitis der Rippen erkennen. F?r zweifelhaft Falle empfiehlt der Verf. auch die Anstellung der Kutanreaktionen. 2) Ein 34 j?hriger Angestellter. Bei diesem Pat. fehlten im ganzen Verlaufe der Krankheit hohes Fieber und Storungen des Magen-Darmkanals vollst?ndig. Die Symp. tome gleichen vollkommen denen der haufig vorkommenden tuberkul?sen oder unspezifischen Periproktitis. Durch die Inzision einer daumengross indurierten Stelle auf der rechten Seite der Anal?ffnung wurden einige zehn Pilzdrusen nachgewiesen, welche den dicken Eiter fast vollst?ndig einnahmen. Die Reinkultur ergab, dass die Pilze obligatanaerob waren. en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=‰ª–{”É kn-aut-sei=‰ª–{ kn-aut-mei=”É aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRçΉȑå›{’ÓcŠO‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=4 article-no= start-page=565 end-page=591 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchungen ?ber die Ursachen der akuten Pankreasnekrose. (IV. Mitteilung) Experimentelle und klinische Studien ?ber die Abfliessung von Pankreassaft in die Gallenwege kn-title=‹}«äXäfšÓŽ€ƒm¬ˆöƒjèƒXƒ‹›‰é„“IŒ¤‹†i‘æ4•ÒjäX‰tä[“¹“à‹t—¬ƒm›‰é„“Iâƒj—ÕଓIŒ¤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=Clairmont und v. Haberer beobachten 1910 einen Fall, der das Sypmtom akuter Peritonitis mit galligem Exsudate darbot. Da bei der Obduktion keine Perforation an den Gallenwegen zu finden war, belegten sie diesen Fall mit dem Namen "perforationslose gallige Peritonitis". Anschliessend an diese Ver?ffentlichung wurden im Laufe der Jahre eine grosse Anzahl analoger F?lle beschrieben und es entspann sich eine so lebhafte Diskussion ?ber den Entstehungsmechanismus dieser Krankheit, dass eine Einigung daruber noch lange nicht zu erwarten ist. Seitdem aber A. Blad 1918 eine neue Theorie der Pankreassaftstauung f?r die Erkl?rung dieser Frage aufgestellt hatte, wurde seine Annahme von Sch?nbauer, Westphal u.a. in Bezug auf die Pankreasfermente nachgepr?ft und man konnte dabei durch Einf?hrung der Pankreasfermente nicht nur eine Verdauungsnekrose der Gallenblasenwand hervorrufen, sondern in einigen F?llen sogar die perforationslose gallige Peritonitis erzeugen. Ferner haben Gundermann, Westphal, Ruppanner, Dziembowsky, Brackerg, Popper u.a. in der Gallenblasengalle eine abnorme Vermehrung von Diastase nachweisen. Der Erscheinungsmechanismus der Pankreasfermente in der Galle ist jedoch von den verschiedenen Beobachtern verschieden festgestellt und gedeutet worden. W?hrend einige Forscher annehmen, dass die Diastase von der Leber abgesondert wird, wird sie von anderen in die Blut- oder Lymphwege eingebracht. Wieder andere betonen sogar die M?glichkeit der Abfliessung des Pankreassaftes in die Gallenwege. Ich habe nur zur Feststellung der Wirkungen, die der Pankrassaft auf die Gallenwege und vor allem auf die Gallenblase aus?bt, bei einer Gruppe der Versuchstiere experimentell die Gallenblase an ihrem Hals unterbunden, bei einer anderen eine Ligatur an den Ductus choledochus angelegt und dann den beiden Gruppen je ein Pr?parat von Pankreassekret resp. Pankreasfermenten eingef?hrt. Daneben habe ich auch den Versuch ausgef?hrt, den Ductus pancreaticus mit der Gallenblase in Kommunikation zu bringen. Ferner habe ich bei 35 Patienten, die wegen Gallensteinkrankheit in unsere Tsuda-Klinik aufgenommen worden waren, in der durch eine Punktion intra operationem gewonnenen Galle den Diastasewert bestimmt und auch die in der Galle der Gallenfistel befindlichen Pankreasfermente fraktionierend untersucht. Bei Versuchshunden habe ich sodann die akute Pankreasnekrose hervorgerufen und die im Blutserum sowohl wie in der Galle befindliche. Diastase fraktionierend aufgefangen und an beiden Diastasen ergleichende Untersuchung angestellt. Am Ende werde ich noch uber einen interessanten klinischen Fall berichten, in dem der Anfall der akuten Pankreasnekrose bei einem Gallensteinkranken wiederholend aufgetreten war. Meine Ergebnisse waren wie folgende: 1. F?lle, in denen die Pankreasfermente nach operativem Cysticusverschluss in die Gallenblase eingef?hrt wurden. a) Bei der Einf?hrung physiologischer Kochsalzl?sung wurden ausser einer Dilatation der Gallenblasenwand keine histologischen Vea?nderungen beobachtet. b) Bei der Einf?hrung von 5% Protamylasel?sung in der Dosis von 1-5cc entstand in 1/3 der s?mtlichen 11 F?lle perforationslose gallige Peritonitis. Histologisch liess sich bis zu 65% eine vollige Nekrose aller Schichten nachweisen. Ausserdem wurden in der Mehrzahl der F?lle Blutungen und Zellinfiltrationen festgestellt. c) Bei der Einfuhrung von 10-40% Diastasel?sung in der Dosis von 2cc wurde die Gallenblase in der Regel am leichtesten gesch?digt, indem ein Peritonealexsudat in keinem Fall beobachtet wurde und nur Blutungen und Zellinfiltrationen in die Erscheinung traten. en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=‰ª–{”É kn-aut-sei=‰ª–{ kn-aut-mei=”É aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRçΉȑå›{’ÓcŠO‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=4 article-no= start-page=547 end-page=564 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchungen ?ber die Ursachen der akuten Pankreasnekrose. (III. Mitteilung) Verbindungsversuche des Ductus choledochus mit dem Ductus pancreaticus durch Duodenum kn-title=‹}«äXäfšÓŽ€ƒm¬ˆöƒjèƒXƒ‹›‰é„“IŒ¤‹†i‘æ3•ÒjãS\“ñŽw’°“Iã`—Aä[ŠÇ—AäXŠÇ˜A—›‰é„ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Bei Hunden m?ndet der accessorische Pankreasgang in die Einm?ndungsstelle des Choledochus ein and davon etwas entfernt findet slch die Einm?ndungsstelle des Hauptgangs des Pankreas, so dass man f?r das Experiment von gemeinsamer Mundung die beiden Ductus kunstlich in Verbindung bringen muss. Nach Anbringung eines L?ngsschnittes an das Duodenum wurde der Ductus choledochus mittelst eines Glasr?hrchens mit dem Ductus pancreaticus verbunden, um die Ver?nderungen des Pankreas sowie des Gallenganges zu untersuchen, and zwar unter der Vorstellung, dass es sich hier um den Fall einer Einklemmung von Gallensteinen in der Papilla duodeni beim menschlichen K?rper handle. Zur Beobachtung wurde nach der Operation eine Gruppe der Versuchstiere auf einem Versuchsstativ befestigt, eine andere auf sich ?berlassen. 1) Unter den 7 Fallen der befestigten Hunde lieferten 3 F?lle das Bild akuter Pankreasnekrose, 2 F?lle das Bild akuter Pankreatitis, 1 Fall eine Degeneration des Pankreas, 1 F?ll das Bild eines akuten Pankreasodems. Bei der Gallenblase wurde eine v?llige Nekrose aller Schichten in 5 F?llen, eine Nekrose des Schleimhautepithels in 2 F?llen festgestellt. Ferner gab es zwei F?lle, in denen der eine durch perforationslose gallige Peritonitis den Tod fand, der andere infolge von Gallenblasenperforation 19 Stunden nach der Operation verendete; in beiden F?llen zeigte das Pankreas ein leichtgradiges ?dem, sonst keine Ver?nderung. Aus alledem geht hervor, dass die ?berfliessung dee pankreatischen Saftes in die Gallenblase fr?her auftritt als die der Galle in den Pankreasgang. 2) Die 7 F?lle, die auf sich selbst ?berlassen wurden, blieben l?nger am Leben (2-8 Tage); 2 F?lle davon hat der Verf. zum Tod gefuhrt. Was die Ver?nderungen des Pankreas anbetrifft, so traten sie in diesen 7 F?llen im Vergleich zu den vorhergehenden in viel leichterem Masse auf; hier wurde namentlich kein Bild der Nekrose beobachtet, akute Pankreatitis liens Bich nur in einem F?ll feststellen, in einem anderen Fall waren die Ver?nderungen nicht erheblich, in den ubrigen 5 F?llen wurde bloss eine dissozierte Degeneration konstatiert. An der Gallenblase traten hingegen Ver?nderungen in so starkem Masse wie in ded oben erw?hnten befestigten F?llen in die Erscheinung: eine v?llige Nekrose alter Schichten wurde in 5 F?llen, Nekrose des Schleimhautepithels in 2 Fallen, gallige Peritonitis mit Perforation in 2 F?llen. ohne Perforation in 1 Fall beobachtet. Diese Erscheinung, dass trotz der intensiven Ver?nderung der Gallenblase die Degeneration des Pankreas nicht nur in leichterem Grade, sondern auch nur in wenigeren F?llen eintrat, kommt daher, dass infolge des starken Drucker der Pankreassekretion der Pankreassaft in die Gallenblase ?berfliesst. 3) Aus den oben geschilderten Ergebnissen ist zu ersehen, dass bei dem postoperativen Zustandekammen gemeinsamer M?ndung von beiden Ductus der Sekretionsdruck des Pankreas den Gallengangsdruck ubertrifft und infolgedessen eine Gegenstr?mung des Pankreassaftes in die Gallenwege oder sogar in die Gallenblase stattfindet, wodurch Verdauungsnekrose, gegebenenfalls gallige Peritonitis mit oder ohne Perforation und pankreatische Peritonitis bedingt wird. Wenn dabei der Druck der Gallenblase sehr gross ist oder von aussen irgendein Druck hinzutritt (z. B. Bauchpresse beim Heulen oder Erbrechen), so erscheint die Annahme nahe liegend, dass die mit dem Pankreassaft durchmischten Galle verkehrt in den Pankreasgang zuruckfliesst und akute Pankreasnekrose hervorruft. en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=‰ª–{”É kn-aut-sei=‰ª–{ kn-aut-mei=”É aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRçΉȑå›{’ÓcŠO‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=3 article-no= start-page=377 end-page=411 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchungen ?ber die Ursachen der akuten Pankreasnekrose. (II. Mitteilung) Druckmessung des Ductus choledochus und pancreaticus auf experimentellem Wege kn-title=‹}«äXäf‰óŽ€ƒm¬ˆöƒjèƒXƒ‹›‰é„“IŒ¤‹†i‘æ2•Òjä[ŠÇäXŠÇŒn“ƒmšØ—Í‘ª’è›‰é„ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Zum Experiment dienten Hunde von ungef?hr 15kg Gewicht, die gut ern?hrt und dressiert werden. Eine kleine Inzision wurde am Ductus choledochus vorgenommen und eine Hepaticuskan?le wurde dann in der Richtung nach der Leber, die Oddische Kan?le in der Richtung nach dem Duodenum eingef?hrt. An die beiden Kan?len wurde je ein Gummirohr angebracht, um die beiden ausserhalb der Bauchwand durch ein U-f?rmiges Rohr zu verbinden. Diese Einrichtung diente dazu, dass die Galle ausser der Zeit der Experimente stets ins Duodenum abfliesst. Mit dem Ductus pancreaticus wurde die Pawlowsche Fistel, oder durch Einf? hrung einer Kan?le in den Hauptgang des Pankreas eine Paukreasgangfistel gebildet. Die erstere ist fur prolongierte Untersuchungen geeignet, die letztere f?r ein unmittelbar nach der Operation auszuf?hrendes Experiment sehr gut anwendbar. Da der pankreatische Saft stets nach aussen abgeflossen war, wurde den Versuchshunden t?glich Protamylase verabreicht. Die Hunde, die 7-10 Tage nach der Operation wieder zu Kr?ften kamen, wurden sodann auf einem Befestigungsstativ fixiert, das U-f?rmige Rohr wurde jetzt ausgel?st und das Druckmessungsrohr wurde verbunden. In die Oddische Kanule habe ich aus der Mariotteschen Flasche unter einem Wasserdruck von 400mm 10-12 Tropfen in jeder Minute eingetropfelt, um die Schwankungen des Druckes, welche infolge von Variationen des Tonus des Oddischen Muskels auftraten, an der Graduierung des angebrachten Messungsrohrs gelesen. Der Druck des Ductus choledochus stellte den Gesamtbetrag der s?mtlichen Drucke dar, die die Gallensekretion, die Entspannung und Kontraktion der Gallenblase, und die Druckwechselung des Bauches hervorbrachten. Der Druck des Ductus pancreaticus war nichts anderes als der Druck der Pankreassekretion und wurde nur an dem. Hauptgang des Pankreas gemessen. Der Druck des Ductus pancreaticus accessorius wurde auf sich gelassen, da er verschwindend klein und seine Messung daher bedeutungslos war. Die oben geschilderte Versuchseinrichtung hatte den Zweck, die Abflussrichtung der Galle und des Pankreatischen Saftes bei Einklemmung der Gallensteine in der Vaterschen Papille oder bei dem Krampf des Oddischen Muskels festzustellen. 1) Bei Verabreichung von Wasser. Nach 24 st?ndiger Inanition wurde Wasser in der Dosis von 500cc verabreicht. Der Ductus pancreaticus zeigte dabei im Laufe von durchschnittlich 25 Minuten den h?chsten Druck von 378mm H(2)O (Drucksteigerung betrug 280mm H(2)O), der Ductus choledochus im Laufe von 24 Minuten 250mm H2O (Drucksteigerung 77mm H(2)O). 2) Bei Verabreichung von Rinderfleisch. Der Ductus pancreaticus lieferte im Verlauf von 25 Minuten den h?chsten Druck von 420mm H(2)O (Drucksteigerung 355mm H(2)O), der Ductus choledochus im Verlauf von 32 Minuten 355mm H(2)O (Drucksteigerung 140mm H(2)O). 3) Bei Verabreichung von Reis. Beim Ductus pancreaticus stieg w?hrend 25 Minuten der Druck bis zu 318mm H(2)O (Druckerh?hung 160mm H(2)O), beim Ductus choledochus w?hrend 27 Minuten bis zu 287mm H(2)O (Drucksteigerung 103mm H(2)O). 4) 2 Stunden nach der F?tterung stieg beim Ductus pancreaticus im Verlauf von 45 Minuten der Druck bis zu 399mm H(2)O, beim Ductus choledochus im Laufe von 47,8 Minuten bis zu 367mm H(2)O. 5) 15-24 Stunden nach der F?tterung gelangte der Ductus pancreaticus im Laufe von durchschnittlich 81 Minuten zum h?chsten Druck von 399mm H(2)O, der Ductus choledochus im Laufe von 83 Minuten zum Druck von 323mm H(2)O. Im Vergleich zum Fall von 2 Stunden nach der F?tterung brachte es hier doppelt so viel Zeit zur Erreichung des h?chsten Druckes, was eine Herabsetzung des Druckes verriet. en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=‰ª–{”É kn-aut-sei=‰ª–{ kn-aut-mei=”É aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRçΉȑå›{’ÓcŠO‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=55 cd-vols= no-issue=3 article-no= start-page=363 end-page=376 dt-received= dt-revised= dt-accepted= dt-pub-year=1943 dt-pub=19430331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimentelle Untersuchungen ?ber die Ursachen der akuten Pankreasnekrose. (I. Mitteilung) ?ber die Wechselbeziehungen zwischen dem Ductus choledochus und dem Ductus pancreaticus an der Einm?ndungsstelle ins Duodenum kn-title=‹}«äXäfšÓŽ€ƒm¬ˆöƒjèƒXƒ‹›‰é„“IŒ¤‹†i‘æ1•Òjã`—Aä[ŠÇƒg—AäXŠÇƒgƒm\“ñŽw’°ŠJŒû•”ƒj‰—ƒPƒ‹‘ŠèXŒW en-subtitle= kn-subtitle= en-abstract= kn-abstract=Seit der Ver?ffentlichung von Opie ?ber die Befunde eines Obduktionsfalles, in dem infolge von Einklemmung kleiner Gallensteine in der Papille eine akute Pankreasnekrose aufgetreten war, sind anatomische Zusammenh?nge der beiden Ductus in der Vaterschen Papille von vielen Forschern eifrig er?rtert worden. Dock die Angaben ?ber die Frequeuz der gemeinsamen M?ndung von Gallengang und Pankreasgang, gehen eft stark auseinander. Das kommt wohl aus der Verschiedenheit der Untersuchungsmethoden einerseits und aus den Rassenunterschieden der die betr. Autoren umschliessenden V?lker andererseits her. Gegen?ber der Angabe von Opie von 89% konnten Mann und Giordano bis zu 20%, Cameron und Noble bis zu 74% der F?lle ein gemeinsames Diverticulum nachweisen. Die M?glichkeit der Gefahr von der Entstehung der gemeinsamen G?nge ist nach Mann und Giordano mit nur 3, 5%, nach Cameron und Noble mit 66%, nach H. Mehnen mit 61% anzusetzen. Ich habe nun bei 45 Materialien frischer menechlicher Sektionsleichen einen Schnitt vom Pylorus bis zur Flexura duodeno-jejunalis ausgef?hrt und zugleich das Pankreas in seiner ganzen Breite mitsamt der Gallenblase und des Choledochus herausgeholt und dasselbe auf einer dicken Pappe befestigt. Sodann habe ich das Duodenum an seiner Aussenseite aufgeschnitten, die Papilla Vateri genau untersucht, von ihr aus die beiden Ductus sondiert und schliesslich dieser Sonde entlang zuerst den Ductus choledochus und dann den Ductus Wirsungianus bis zum kaudalen Ende inzidiert. Vor der Er?ffnung derKanallumen habe ich indes die Vatersche Papille mit Tabaksbeutelnaht verschlossen, in den Ductus choledochus Morjodol in der Dosis von 3-4cc eingef?hrt und auf dem R?ntgenbild sowohl das feine Ver?stelungswerk des Ductus pancreaticus als auch die Wechselbesiehungen zwischen den beiden Ductus sowie die Anwesenheit des Ductus pancreaticus acoesorius untersucht. Die Ergebnisse waren wie folgt: 1) Bei 45 Materialien menechlicher Sektionaleichen habe ich die Wechselbeziehungen beider Ductus an der gemeinschaftlichen M?ndungsstelle in 3 Typen einteilend untersucht. 2) Zum I. Typ geh?ren 42 Falle (93%), in welchen die beiden Ductus eine Papille und ein gemeinsames Diverticulum besitzen. Zieht man davon die 4 F?lle ab, deren gemeinsames Diverticulum mit einer bis kranialen Ende verlaufenden d?nnen membran?sen Scheidewand versehen ist und infolgedessen kein gemeinsames Lumen mehr aufweist, so schliesst der I. Typ 38 F?lle (84%) ein. Der II. Typ besteht aus nur einem Fall (2%) mit 2 Papillen, welche jede f?r sich eine selbst?ndige M?ndung haben. Der III. Typ besteht aus 2 F?llen (5%), in denen das Duodenum kein eigenes Diverticulum Vateri besitzt und daf?r der Ductue pancreaticus unmittelbar in den Ductus choledochus einm?ndet. In beiden F?llen liegt die M?ndungsstelle von der M?ndung des Ductus choledochus weit entfernt ab: in dem einen betr?gt die Strecke 15mm, in dem anderen 10mm. In den beiden F?llen m?ndet der Ductus pancreaticus ins den Ductus choledochus in einem ann?hernd rechten Winkel ein. 3) Die Gefahr, durch Einklemmung der Gallensteine in der Papille gemeinsame M?ndung von Gallengang und Pankreasgang entstehen kann, besteht in 34 F?llen unter den s?mtlichen 45 F?llen (76%). 4) Der Ductus pancreaticus accessorius ist in 9 F?llen anzutreffen, die 20% der 45 F?lle ausmacht. Er ist aber unter den 14 F?llen, die besonders r?ntgenologisch untersucht worden sind, in 6 F?llen, also bis zu 43, 5% festgestellt. en-copyright= kn-copyright= en-aut-name=OkamotoShigeru en-aut-sei=Okamoto en-aut-mei=Shigeru kn-aut-name=‰ª–{”É kn-aut-sei=‰ª–{ kn-aut-mei=”É aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽRçΉȑå›{’ÓcŠO‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=7 article-no= start-page=1405 end-page=1414 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ŽáØ•a‚ÉŠÖ‚·‚éŽÀŒ± ‘æŽO•Ò ŽÀŒ±“Içê’ŽŒ¢iŒoŒûŠ´õj‚̃eƒgƒŒƒ“‹z“üŽÀŒ± en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”–kŽR“à‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=7 article-no= start-page=1398 end-page=1404 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ŽáØ•a‚ÉŠÖ‚·‚éŽÀŒ± ‘æ“ñ•Ò ŽÀŒ±“Içê’ŽŒ¢iŒoŒûŠ´õj‚Ì”x‚ÌŠŒ© en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”–kŽR“à‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=7 article-no= start-page=1391 end-page=1397 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520731 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ŽáØ•a‚ÉŠÖ‚·‚éŽÀŒ± ‘æˆê•Ò ŽÀŒ±“Içê’ŽŒ¢iŒoŒûŠ´õj‚Ì—Õ°“IŠÏŽ@ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”–kŽR“à‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=1 article-no= start-page=154 end-page=163 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=lˆÝ‚Ì—L‚·‚é‘¢ŒŒ•¨Ž¿‚ÉA‚Ä‚ÌŒ¤‹† ‘æ3•Ò ˆÝ‰t’†‚Ì‘¢ŒŒˆöŽq‚ÉŠÖ‚·‚錟õiSinges‚ÌR. 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R‹y‚ÑDuesbergŽ”½‰žj en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{‰Ã”V kn-aut-sei=‰ª–{ kn-aut-mei=‰Ã”V aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”’ÓcŠO‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=1 article-no= start-page=148 end-page=153 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=lˆÝ‚Ì—L‚·‚é‘¢ŒŒ•¨Ž¿‚ÉA‚Ä‚ÌŒ¤‹† ‘æ2•Ò ˆÝ‘gD’†‚Ì“ûŽ_‹Û‘BˆöŽqi—tŽ_j‚ÉA‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{‰Ã”V kn-aut-sei=‰ª–{ kn-aut-mei=‰Ã”V aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”’ÓcŠO‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=64 cd-vols= no-issue=1 article-no= start-page=132 end-page=147 dt-received= dt-revised= dt-accepted= dt-pub-year=1952 dt-pub=19520131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=lˆÝ‚Ì—L‚·‚é‘¢ŒŒ•¨Ž¿‚ÉA‚Ä‚ÌŒ¤‹† ‘æ1•Ò ˆÝ‘gD’†‚ÌŠˆàCastle‚Ì‘¢ŒŒ•¨Ž¿‚ÉA‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{‰Ã”V kn-aut-sei=‰ª–{ kn-aut-mei=‰Ã”V aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”’ÓcŠO‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=1 article-no= start-page=28 end-page=36 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=p‘OŒã‚ɉ—‚¯‚éŠÌ‹@”\‚ÌÁ’·•À‚É”V‚É‹y‚Ú‚·‘Šú—£°C‰·ò—‚̉e‹¿‚ÉŠÖ‚·‚錤‹† ‘æŽO•Ò ‰·ò—‚̉e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œö›š kn-aut-sei=‰ª–{ kn-aut-mei=Œö›š aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‰·òŒ¤‹†ŠŠO‰È END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=1 article-no= start-page=17 end-page=27 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=p‘OŒã‚ɉ—‚¯‚éŠÌ‹@”\‚ÌÁ’·•À‚É”V‚É‹y‚Ú‚·‘Šú—£°C‰·ò—‚̉e‹¿‚ÉŠÖ‚·‚錤‹† ‘æ“ñ•Ò ‘Šú—£°‚̉e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œö›š kn-aut-sei=‰ª–{ kn-aut-mei=Œö›š aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‰·òŒ¤‹†ŠŠO‰È END start-ver=1.4 cd-journal=joma no-vol=65 cd-vols= no-issue=1 article-no= start-page=4 end-page=16 dt-received= dt-revised= dt-accepted= dt-pub-year=1953 dt-pub=19530131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=p‘OŒã‚ɉ—‚¯‚éŠÌ‹@”\‚ÌÁ’·•À‚É”V‚É‹y‚Ú‚·‘Šú—£°C‰·ò—‚̉e‹¿‚ÉŠÖ‚·‚錤‹† ‘æˆê•Ò “ñCŽOŠO‰ÈŽèp‘OŒã‚ɉ—‚¯‚éŠÌ‹@”\‚ÌÁ’· en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=‰ª–{Œö›š kn-aut-sei=‰ª–{ kn-aut-mei=Œö›š aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‰·òŒ¤‹†ŠŠO‰È END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=12 article-no= start-page=2611 end-page=2628 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Hypoplastic Anemia (panmyelopathy); (Mainly depending on our departmental experiences) kn-title=”Ĝ钕aiĶ•s—Ç«•nŒŒj‚ɂ‚¢‚Ä\‹³Žº‚ÌŒoŒ±‚ð’†S‚Æ‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Japan, hypoplastic anemia has ever been presenting one of the most important problems among today's anemic diseases, it having proved as great frequency as that of pernicious anemia found both in Europe and America; besides, no fit therapeutic method been discovered as yet. Generally speaking, this disease shows a decrease of entire corpuscles, the bleeding tendency becoming prevalent in most cases; yet as to signs in concern to bone marrow, the number of nuclear cell is not fixed, as it has proved 16, 200 at the lowset, while, 263, 000 at the highest. Consequently, it has been classified into 5 types in our department, in view to obstructions of bone marrow. 1. Type of bloodcell-arrest. 2. Type of maturation-arrest. 3. Type of disturbanced regeneration. 4. Mixed type. 5. Panmyelophthisis. When we took record about 23 cases of hypoplastic patients, results were as follows; 1st type 7, 2nd type 2, 3rd type 3, 4th type 8, and 3 cases of 5th type. In all serum iron value proved an increase; in view to intravenous iron tolerance test, the degree of iron disappearance proved a marked delay, while hematopoetic function indicated an extreme decline. In tissue culture of bone marrow invented by our department. it has been recognized that there exists certain factor to inhibit any hyperplasia of parencyma of bone marrow in this anemic serum. As for method in therapy, several have been nominated through in vain, so that more or less effect have been achieved only by our inventions, i.e., imbedding of bone marrow as well as use of substances of polysaccharide extracted from bone marrow. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= en-aut-name=OkanoTakuya en-aut-sei=Okano en-aut-mei=Takuya kn-aut-name=‰ª–ì‘ì–ç kn-aut-sei=‰ª–ì kn-aut-mei=‘ì–ç aut-affil-num=2 ORCID= en-aut-name=SaitoTetsuro en-aut-sei=Saito en-aut-mei=Tetsuro kn-aut-name=ꎓ¡“N˜Y kn-aut-sei=ꎓ¡ kn-aut-mei=“N˜Y aut-affil-num=3 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name=–Ø‘ºˆè˜Y kn-aut-sei=–Ø‘º kn-aut-mei=ˆè˜Y aut-affil-num=4 ORCID= en-aut-name=TanakaMotosuke en-aut-sei=Tanaka en-aut-mei=Motosuke kn-aut-name=“c’†Šî‰î kn-aut-sei=“c’† kn-aut-mei=Šî‰î aut-affil-num=5 ORCID= en-aut-name=YamashitaMiyokichi en-aut-sei=Yamashita en-aut-mei=Miyokichi kn-aut-name=ŽR‰ºŽO‘ã‹g kn-aut-sei=ŽR‰º kn-aut-mei=ŽO‘ã‹g aut-affil-num=6 ORCID= en-aut-name=ShindoTsutomu en-aut-sei=Shindo en-aut-mei=Tsutomu kn-aut-name=i“¡•× kn-aut-sei=i“¡ kn-aut-mei=•× aut-affil-num=7 ORCID= en-aut-name=KuninobuMasuhiro en-aut-sei=Kuninobu en-aut-mei=Masuhiro kn-aut-name=‘‰„‰vO kn-aut-sei=‘‰„ kn-aut-mei=‰vO aut-affil-num=8 ORCID= en-aut-name=TominagaHiroshi en-aut-sei=Tominaga en-aut-mei=Hiroshi kn-aut-name=•x‰iO kn-aut-sei=•x‰i kn-aut-mei=O aut-affil-num=9 ORCID= en-aut-name=IshidaToyoshige en-aut-sei=Ishida en-aut-mei=Toyoshige kn-aut-name=Γc–Ld kn-aut-sei=Γc kn-aut-mei=–Ld aut-affil-num=10 ORCID= en-aut-name=TakedaToshiteru en-aut-sei=Takeda en-aut-mei=Toshiteru kn-aut-name=•“cr‹P kn-aut-sei=•“c kn-aut-mei=r‹P aut-affil-num=11 ORCID= en-aut-name=NumamotoTetsuro en-aut-sei=Numamoto en-aut-mei=Tetsuro kn-aut-name=À–{“O˜Y kn-aut-sei=À–{ kn-aut-mei=“O˜Y aut-affil-num=12 ORCID= en-aut-name=KotakemoriYasuo en-aut-sei=Kotakemori en-aut-mei=Yasuo kn-aut-name=¬•Žç–õ kn-aut-sei=¬• kn-aut-mei=Žç–õ aut-affil-num=13 ORCID= en-aut-name=NakayamaAkio en-aut-sei=Nakayama en-aut-mei=Akio kn-aut-name=’†ŽRÍ‘s kn-aut-sei=’†ŽR kn-aut-mei=Í‘s aut-affil-num=14 ORCID= en-aut-name=HoenSachihiko en-aut-sei=Hoen en-aut-mei=Sachihiko kn-aut-name=•û‰~K•F kn-aut-sei=•û‰~ kn-aut-mei=K•F aut-affil-num=15 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=8 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=9 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=10 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=11 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=12 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=13 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=14 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È affil-num=15 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È END start-ver=1.4 cd-journal=joma no-vol=66 cd-vols= no-issue=11 article-no= start-page=2289 end-page=2307 dt-received= dt-revised= dt-accepted= dt-pub-year=1954 dt-pub=19541130 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=STATISTICAL OBSERVATION ON 28 CASES OF HYPOP-LASTIC ANEMIA. (PANMYELOPATHIA) kn-title=”Ĝ钕aÇiĶ•s—Ç«•nŒŒj28—á‚Ì“Œv“IŠÏŽ@ en-subtitle= kn-subtitle= en-abstract= kn-abstract=We have taken observations on 28 cases of Panmyelopathia, all of which belonged to inpatients of our dept., statistically and clinically; results were as follows:- There were found no definite co-relations either iu age, sex. or by occupation; except 1 case of chronic X-Ray injury; for conscious symptoms, facial paleness was found almost inevitably, while fever, general languor, and palpitation were discovered to succeed it; as for the bleeding, in main it was wont to appear in the form of gingival bleeding, epistaxis, or ecchymosis; for symptoms that were discovered by others, red-cell sedimentation rate was found to be stimulated, in total cases, and such as lengthened bleeding time, anemic cardiac murmurs, together with changes in the eye ground, was recognizable in most cases. Among the blood figure. number of red cells was seen to be about a million or so in majority of cases; while, figures below 1 million was considered to point at serious prognosis. As to hemoglobin content, in most cases, it occupied 20% or so; in respect to hemoglobin index, most of them indicated a hyperchrom, over the entire process, or in partial process. In most cases, the numher of leucocytes proved to be short of 4000, which was also supposed to keep much co-relation with the prognosis. In view to differentiation of lencocytes, a decrease of grauulocytes, an increase of lymphocytes appeared, and in general, in deceased cases, lymphocytosis was clearly observed. Number of blood platelet were apt to decrease to a certain extent. Number of reticulocytes was seen to be small in majority of cases, but it would seem unreasonable to refer to it for the state of prognosis. Heinz' body proved, in serious cases, a value pretty nigh to 1, 000ñ, showing a great difference with that, belonging to another sort of anemic diseases, as well as people in healthy condition. No special phase was foundin the myelogramm; in respective disease, various apperances of hematopoetic functions observed. The disease could generally be divided into following 5 types. I. Type of bloodcell-arrest. II. Type of maturation-arrest III. Type of disturbanced regeneration. IV. Mixed type. V. Panmyelophthisis. By dint of Tissue Culture of bone marrow. it has been supposed that there existed certain factor that inhibited growth of parenchyma of bone marrow directly; moreover, the functions of bone marrow have suffered a marked hindrance; Having examined respiration and glycolysis in bone marrow, it was discovered that with type of blodcell-arrest, it has proved normal; with other typs, proved considerablly low value. Its sideroblastogram proved slightly to shift to the right. Generally in most cases, gastric juice showed certain hypoacidity. Among the circulatory system, no unique quality discovered, while the rise in serum iron value was seen, owing to extreme decrease of hematopoetic function. Amongst urine and cerebrospinal fluid, some anemia-causing substance has been detected. As for sugar metabolism, rate for normal and abnormal stood almost the same; while as for the basal metabolism, there was discovered some abnormality. The function test of autonomic nervous system, also showed much abnormality. As to histological view, a high degree atrophy was discovered in hematopoetic tissue, with a marked bleeding tendency. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= en-aut-name=NumamotoTetsuro en-aut-sei=Numamoto en-aut-mei=Tetsuro kn-aut-name=À–{“O˜Y kn-aut-sei=À–{ kn-aut-mei=“O˜Y aut-affil-num=2 ORCID= en-aut-name=TamuraHajime en-aut-sei=Tamura en-aut-mei=Hajime kn-aut-name=“c‘º•á kn-aut-sei=“c‘º kn-aut-mei=•á aut-affil-num=3 ORCID= en-aut-name=OkanoTakuya en-aut-sei=Okano en-aut-mei=Takuya kn-aut-name=‰ª–ì‘ì–ç kn-aut-sei=‰ª–ì kn-aut-mei=‘ì–ç aut-affil-num=4 ORCID= en-aut-name=KitayamaMinoru en-aut-sei=Kitayama en-aut-mei=Minoru kn-aut-name=–kŽR–« kn-aut-sei=–kŽR kn-aut-mei=–« aut-affil-num=5 ORCID= en-aut-name=TakedaKatsumi en-aut-sei=Takeda en-aut-mei=Katsumi kn-aut-name=•“cŸ”ü kn-aut-sei=•“c kn-aut-mei=Ÿ”ü aut-affil-num=6 ORCID= en-aut-name=TsushimaMakoto en-aut-sei=Tsushima en-aut-mei=Makoto kn-aut-name=’Ó‡ˆò kn-aut-sei=’Ó‡ kn-aut-mei=ˆò aut-affil-num=7 ORCID= en-aut-name=NakatsukaGinta en-aut-sei=Nakatsuka en-aut-mei=Ginta kn-aut-name=’†’ˋ⑾ kn-aut-sei=’†’Ë kn-aut-mei=‹â‘¾ aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È‹³Žº affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È‹³Žº affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È‹³Žº affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È‹³Žº affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È‹³Žº affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È‹³Žº affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È‹³Žº affil-num=8 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•½–Ø“à‰È‹³Žº END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=2 article-no= start-page=59 end-page=98 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Income Distribution and Tax Reforms in Aging Japan kn-title=Š“¾•ª•z‚Æ‚—ŽÐ‰ï‚É‚¨‚¯‚éŧ‰üŠv en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper examines the effects of changes in the variance of income distribution on both capital accumulation and social welfare in Japan, the society with an aging population. To analyze the problem, we adopt a simulation approach for an extended life-cycle general equilibrium model of overlapping generations with continuous income distribution. The simulation results indicate that the changes in the variance affect economic variables under a progressive tax scheme but they do not under a proportional tax scheme. The results also show that social welfare greatly increases as the variance shrinks. Therefore, the recent shift in Japan, where the taxation system has tended in effect to become flat, may cause a significant damage to social welfare. en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name=‰ª–{Í kn-aut-sei=‰ª–{ kn-aut-mei=Í aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=32 cd-vols= no-issue=1 article-no= start-page=1 end-page=48 dt-received= dt-revised= dt-accepted= dt-pub-year=2000 dt-pub=20000610 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Heterogeneous Labor Endowments and Tax Reforms in Aging Japan: Progressive Taxes and Intragenerational Redistribution kn-title=˜J“­ˆÙŽ¿«‚Æ‚—ŽÐ‰ï‚É‚¨‚¯‚éŧ‰üŠv\—Ýiŧ‚Ì‘I‘ð‚ÆŽ‘ŽYŠi·‚ւ̉e‹¿\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper examines the effects of a progressive labor income tax scheme and a progressive consumption tax scheme on capital stock and on intragenerational wealth distribution in Japan, the society with an aging population. To analyze the problem, we adopt a simulation approach for an extended life-cycle general equilibrium model of overlapping generations. As a progressive tax is likely to mitigate the inequality of resource distribution, it is crucial to allow for the existence of heterogeneous labor. This is incorporated by assuming that each cohort has three representative individuals with equal tastes but unequal annual labor endowments, corresponding to three income classes, namely, low, middle, and high income classes. As the simulation results indicate, a progressive labor income tax shrinks the inequality in the distribution of wealth, while a progressive consumption tax furthers slightly. en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name=‰ª–{Í kn-aut-sei=‰ª–{ kn-aut-mei=Í aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=9-10 article-no= start-page=887 end-page=899 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histological study of neuronal damage following 18 minutes of global brain ischemia in dogs kn-title=18•ªŠÔŠ®‘S‘S”]‹•ŒŒŒ¢‚Ì”]‘gDáŠQ‚ÉŠÖ‚·‚éŽÀŒ±“IŒ¤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=The neuronal damage of small to medium sized striatal neurons, hippocampal CA1 pyramidal cells and cerebellar Purkinje cells was histologically studied after reperfusion following 18 minutes of global brain ischemia in dogs. Neuronal damage of small to medium sized striatal neurons progressed up to 6 hours after reperfusion, but further damage was not observed from 6 hours to 7 days after reperfusion. Little damage of either the hippocampal CA1 pyramidal cells or cerebellar Purkinje cells was observed 6 hours after reperfusion, but severe delayed damage of those cells was observed from 24 to 48 hours after reperfusion. These results suggest that the delayed onset of neuronal damage of both hippocampal CA1 pyramidal cells and cerebellar Purkinje cells is due to secondary injury factor (s) after reperfusion subsequent to ischemia. The delayed neuronal damage in this model may be prevented or reduced by treatment of secondary injury factor (s). en-copyright= kn-copyright= en-aut-name=OkamotoTakayuki en-aut-sei=Okamoto en-aut-mei=Takayuki kn-aut-name=‰ª–{—²s kn-aut-sei=‰ª–{ kn-aut-mei=—²s aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”–ƒŒE‘h¶Šw‹³Žº en-keyword=‘S”]‹•ŒŒ kn-keyword=‘S”]‹•ŒŒ en-keyword=ƒCƒk kn-keyword=ƒCƒk en-keyword=ŠC”nCA1 kn-keyword=ŠC”nCA1 en-keyword=ƒvƒ‹ƒLƒ“ƒG×–E kn-keyword=ƒvƒ‹ƒLƒ“ƒG×–E en-keyword=üð‘Ì kn-keyword=üð‘Ì END start-ver=1.4 cd-journal=joma no-vol=101 cd-vols= no-issue=5-6 article-no= start-page=505 end-page=515 dt-received= dt-revised= dt-accepted= dt-pub-year=1989 dt-pub=198906 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Test for susceptibility to anticancer drugs by human tumor clonogenic assay and anticancer effects of natural human tumor necrosis factor-ƒ¿ and natural human interferon-ƒ¿ kn-title=Human tumor clonogenic assay‚ð—p‚¢‚½§ŠàÜŠ´Žó«ŽŽŒ±‚Ænatural human Tumor Necrosis Factor‚ÌRŽîᇌø‰Ê‚ÉŠÖ‚·‚錤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=The human tumor clonogenic assay is a test of susceptibility to anticancer drugs which is known to correlate well with clinical effects. In this report, this assay was used to study the antitumor effects of several anticancer drugs and human tumor necrosis factor-ƒ¿ (nHuTNF-ƒ¿), and the combination effect of nHuTNF-ƒ¿ and natural human interferon-ƒ¿ (nHuIFN-ƒ¿). Susceptibility to exisiting anticancer drugs was studied in 94 cases involving 92 patients. Colony formation was obtained 50 cases (53.2%). Of these, susceptibility to ADM was found in 15 cases, to MMC in 8 cases and to 5-Fu in 11 cases. When the antitumor effect of nHuTNF-ƒ¿ was studied in 10 cases obtained from patients with malignant tumor, colony inhibition was shown in 9 cases of more than 30% with 100 units and more than 50% with 300 units. A synergistic effect was assessed with a combination of nHuTNF-ƒ¿ and nHuIFN-ƒ¿ against 4 cell lines (KB, Hep-2, KATO-III, PC-9). The results showed a synergistic effect in KB and Hep-2 cell culture system. From these results, nHuTNF-ƒ¿ seemed to be effective anticancer drugs. The synergistic antitumor effect may be expected if the combination of nHuTNF-ƒ¿ and nHuIFN-ƒ¿ was used clinically. en-copyright= kn-copyright= en-aut-name=OkamotoKanji en-aut-sei=Okamoto en-aut-mei=Kanji kn-aut-name=‰ª–{Š²Ži kn-aut-sei=‰ª–{ kn-aut-mei=Š²Ži aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆêŠO‰ÈŠw‹³Žº en-keyword=Human tumor clonogenic assay kn-keyword=Human tumor clonogenic assay en-keyword=RŠàÜŠ´Žó«ŽŽŒ± kn-keyword=RŠàÜŠ´Žó«ŽŽŒ± en-keyword=natural human interferon-ƒ¿ kn-keyword=natural human interferon-ƒ¿ en-keyword=natural human tumor necrosis factor-ƒ¿ kn-keyword=natural human tumor necrosis factor-ƒ¿ en-keyword=preclinical early phase II study kn-keyword=preclinical early phase II study END start-ver=1.4 cd-journal=joma no-vol=122 cd-vols= no-issue=3 article-no= start-page=231 end-page=236 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20101201 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of transverse colon cancer with remarkable extramural invasion to stomach and jejunum kn-title=•ÇŠO«‚ÉŽîᎂðŒ`¬‚µˆÝE¬’°Z‚ðŽ¦‚µ‚½‰¡sŒ‹’°Šà‚Ì‚P—á en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 77-year-old woman was admitted to our hospital due to abdominal pain and body weight loss. A palpable mass the size of an infant's head was tender on palpation and identified as an epigastric lesion. Colonoscopic examination revealed stenosis of the transverse colon, although no intraluminal growth of the tumor was found. The histologic findings of the biopsy material were poorly differentiated and/or undifferentiated cells. Abdominal CT scan showed an irregular-shaped tumor with a diameter of 10cm invading the stomach and jejunum. We performed an operation under a diagnosis of extramurally growing cancer or malignant lymphoma of the colon. Partial resection of the transverse colon was done by distal gastrectomy and partial resection of the jejunum. Histologic examination of the operative specimens revealed moderately differentiated adenocarcinoma of the transverse colon, prominently proliferating into the surrounding tissues. The finding of a long stenotic lesion and extramural compression by colonography are characteristic of this tumor, based on a review of 43 literature reports in Japan. en-copyright= kn-copyright= en-aut-name=HamanoRyosuke en-aut-sei=Hamano en-aut-mei=Ryosuke kn-aut-name=à_–ì—º•ã kn-aut-sei=à_–ì kn-aut-mei=—º•ã aut-affil-num=1 ORCID= en-aut-name=OtsukaShinya en-aut-sei=Otsuka en-aut-mei=Shinya kn-aut-name=‘å’ËáÁÆ kn-aut-sei=‘å’Ë kn-aut-mei=áÁÆ aut-affil-num=2 ORCID= en-aut-name=KimuraYuuji en-aut-sei=Kimura en-aut-mei=Yuuji kn-aut-name=–Ø‘º—TŽi kn-aut-sei=–Ø‘º kn-aut-mei=—TŽi aut-affil-num=3 ORCID= en-aut-name=NishieManabu en-aut-sei=Nishie en-aut-mei=Manabu kn-aut-name=¼]Šw kn-aut-sei=¼] kn-aut-mei=Šw aut-affil-num=4 ORCID= en-aut-name=TokunagaNaoyuki en-aut-sei=Tokunaga en-aut-mei=Naoyuki kn-aut-name=“¿‰i®”V kn-aut-sei=“¿‰i kn-aut-mei=®”V aut-affil-num=5 ORCID= en-aut-name=MiyasouHideaki en-aut-sei=Miyasou en-aut-mei=Hideaki kn-aut-name=‹{@G–¾ kn-aut-sei=‹{@ kn-aut-mei=G–¾ aut-affil-num=6 ORCID= en-aut-name=TsunemituYousuke en-aut-sei=Tsunemitu en-aut-mei=Yousuke kn-aut-name=íŒõ—m•ã kn-aut-sei=íŒõ kn-aut-mei=—m•ã aut-affil-num=7 ORCID= en-aut-name=InagakiMasaru en-aut-sei=Inagaki en-aut-mei=Masaru kn-aut-name=ˆîŠ_—D kn-aut-sei=ˆîŠ_ kn-aut-mei=—D aut-affil-num=8 ORCID= en-aut-name=IwakawaKazuhide en-aut-sei=Iwakawa en-aut-mei=Kazuhide kn-aut-name=Šâì˜aG kn-aut-sei=Šâì kn-aut-mei=˜aG aut-affil-num=9 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=ŠâŠ_”Ž–¤ kn-aut-sei=ŠâŠ_ kn-aut-mei=”Ž–¤ aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=2 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=3 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=4 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=5 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=6 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=7 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=8 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=9 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È affil-num=10 en-affil= kn-affil=‘—§•a‰@‹@\•ŸŽRˆã—ÃZƒ“ƒ^[@ŠO‰È en-keyword=‘å’°Šà (colon cancer) kn-keyword=‘å’°Šà (colon cancer) en-keyword=•ÇŠO«”­ˆç (extraluminal growth) kn-keyword=•ÇŠO«”­ˆç (extraluminal growth) END start-ver=1.4 cd-journal=joma no-vol=36 cd-vols= no-issue=4 article-no= start-page=193 end-page=201 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050310 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Introduction of Progressive Expenditure Taxation to Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=With a population that is aging faster than any other in the world, Japan faces serious public finance problems, particularly when it comes to tax and social security issues. The structural reforms are urgently needed to accommodate the impending demographic change. We look at the Japanese tax and social security systems through a life?cycle general equilibrium simulation model. We aim to establish guidelines for fiscal reform in Japanfs graying society and use such advanced modeling techniques to permit the calculation of the effects of alternative tax policies on capital accumulation and economic welfare. We also examine the impact of progressive expenditure taxation, coming to the novel conclusion that this form of taxation may hold the key to overcoming the large welfare loss Japan faces as its society ages under the current tax system. Furthermore, we present the concrete measures of implementing progressive expenditure taxation. en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=Faculty of Economics, Okayama University END start-ver=1.4 cd-journal=joma no-vol=42 cd-vols= no-issue=2 article-no= start-page=47 end-page=75 dt-received= dt-revised= dt-accepted= dt-pub-year=2010 dt-pub=20100910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Welfare Analysis of Progressive Expenditure Taxation in Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=This paper aims to establish guidelines for public pension reform in an aging Japan, using a numerical simulation approach. The paper examines the effects of demographic change and public pension policies on economic growth and welfare, using a dynamic life-cycle general equilibrium model. It deals with the benchmark case with the current Japanese pension schedule based on the 2004 reform, and the reform cases in which the whole basic pension benefit is financed by a consumption tax and in which the earnings-related pension is abolished. Moreover, it handles the case in which a progressive expenditure (or consumption) tax is introduced. The simulation results show that the level of economic welfare is higher under these reforms than under the current pension schedule. en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name=‰ª–{Í kn-aut-sei=‰ª–{ kn-aut-mei=Í aut-affil-num=1 ORCID= en-aut-name=ShimaToshihiko en-aut-sei=Shima en-aut-mei=Toshihiko kn-aut-name=“‡r•F kn-aut-sei=“‡ kn-aut-mei=r•F aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=University of Tokyo en-keyword=Aging population kn-keyword=Aging population en-keyword=Public pension reform kn-keyword=Public pension reform en-keyword=Basic pension kn-keyword=Basic pension en-keyword=Progressive expenditure tax kn-keyword=Progressive expenditure tax en-keyword=Life-cycle general equilibrium simulation model kn-keyword=Life-cycle general equilibrium simulation model END start-ver=1.4 cd-journal=joma no-vol=73 cd-vols= no-issue=1-2 article-no= start-page=59 end-page=66 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200311 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Alternative methods to evaluate the protective ability of sunscreen against photo-genotoxicity en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Numerous epidemiological investigations show that sunlight is carcinogenic to humans and that the use of sunscreen may be effective in decreasing the risk of skin cancer. The biological activity of a sunscreen is evaluated by its ability to protect human skin from erythema as represented by a Sun Protection Factor (SPF). We propose that the sunscreen's protective effect against sunlight-induced genotoxicity, including mutation, should also be taken into account. In this study we examined the protective ability of sunscreens against natural sunlight and UV-induced genotoxicity in Drosophila somatic cells. We prepared three kinds of sunscreen samples, each with an SPF value of 20, 40 or 60 and compared their protective activities with commercial sunscreens. When a sunscreen of SPF 20, 40 or 60 was pasted on the plastic cover of a petri dish in which Drosophila larvae were exposed to the sun or UV lamps, genotoxicity decreased as the SPF of the sunscreen increased, relative to levels of genotoxicity observed in samples without sunscreen. However, the protective abilities of sunscreens were unexpectedly not so different from each other. To reveal the relationship between the protective activity of sunscreen and the wavelength of light with which larvae were irradiated through the sunscreen, we measured the transmittance of light through the petri dish cover on which the sunscreen was pasted. Effective protection was demonstrated by removing components of light whose wavelengths were below 315 nm. We suggest, that the measurement of anti-genotoxic activity and the determination of the wavelengths of light transmitted through the sunscreen should be an alternative method for evaluating the effectiveness of a sunscreen.

en-copyright= kn-copyright= en-aut-name=ToyoshimaMegumi en-aut-sei=Toyoshima en-aut-mei=Megumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HosodaKanako en-aut-sei=Hosoda en-aut-mei=Kanako kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HanamuraMiho en-aut-sei=Hanamura en-aut-mei=Miho kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KobayashiHiroshi en-aut-sei=Kobayashi en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NegishiTomoe en-aut-sei=Negishi en-aut-mei=Tomoe kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Shiseido Research Center affil-num=6 en-affil= kn-affil=Okayama University en-keyword=sunscreen kn-keyword=sunscreen en-keyword=sunlight kn-keyword=sunlight en-keyword=UVB kn-keyword=UVB en-keyword=somatic cell mutation kn-keyword=somatic cell mutation en-keyword=genotoxicity kn-keyword=genotoxicity en-keyword=transmittance kn-keyword=transmittance en-keyword=Drosophila melanogaster kn-keyword=Drosophila melanogaster END start-ver=1.4 cd-journal=joma no-vol=57 cd-vols= no-issue=6 article-no= start-page=267 end-page=277 dt-received= dt-revised= dt-accepted= dt-pub-year=2003 dt-pub=200312 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Pathophysiological functions of CD30+ CD4+ T cells in rheumatoid arthritis. en-subtitle= kn-subtitle= en-abstract= kn-abstract=

High levels of soluble CD30 (sCD30) were detected in the serum and synovial fluid of patients with rheumatoid arthritis (RA), indicating the involvement of CD30+ T cells in the pathogenesis. We investigated the induction of CD30 and its functions in CD4+T cells from patients with established RA (disease duration >_2 years). CD4+ T cells from both the peripheral blood (PB) and synovial tissue (ST) of RA patients expressed surface CD30 when stimulated with anti-CD3 antibody (Ab) and anti-CD28 Ab, but their CD30 induction was slower and weaker compared with PB CD4+ T cells of healthy controls (HC). Immunohistochemical analysis showed that only a small proportion of lymphocytes expressed CD30 in the ST (-1%). RA PB CD4+ T cells, after recovery from 6-day stimulation with anti-CD3 Ab and anti-CD28 Ab, showed in intracellular cytokine staining that CD30+ T cells could produce more interleukin-4 (IL-4) but less interferon-gamma. In the culture of RA PB CD4+ T Cells with anti-CD3 Ab and anti-CD28 Ab, blocking anti-CD30 Ab similarly inhibited the cell proliferation and activation of nuclear factor-kappaB on day 4 in RA and HC, but inhibited the apoptotic cell death on day 6 only in RA. These results indicate that despite high-level expression of sCD30, the anti-inflammatory activity of IL-4-producing CD30+ CD4+ T cells may be limited in the ST due to a poor induction of surface CD30 and a susceptibility to CD30-mediated cell death.

en-copyright= kn-copyright= en-aut-name=OkamotoAkira en-aut-sei=Okamoto en-aut-mei=Akira kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=YamamuraMasahiro en-aut-sei=Yamamura en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IwahashiMitsuhiro en-aut-sei=Iwahashi en-aut-mei=Mitsuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AitaTetsushi en-aut-sei=Aita en-aut-mei=Tetsushi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=UenoAkiko en-aut-sei=Ueno en-aut-mei=Akiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=KawashimaMasanori en-aut-sei=Kawashima en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=YamanaJiro en-aut-sei=Yamana en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=KagawaHidetoshi en-aut-sei=Kagawa en-aut-mei=Hidetoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=MakinoHirofumi en-aut-sei=Makino en-aut-mei=Hirofumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University en-keyword=apoptosis kn-keyword=apoptosis en-keyword=CD4 Tcells kn-keyword=CD4 Tcells en-keyword=CD30 kn-keyword=CD30 en-keyword=interleukin-4(IL=4) kn-keyword=interleukin-4(IL=4) en-keyword=rheumatoid arthritis(RA) kn-keyword=rheumatoid arthritis(RA) END start-ver=1.4 cd-journal=joma no-vol=62 cd-vols= no-issue=6 article-no= start-page=363 end-page=371 dt-received= dt-revised= dt-accepted= dt-pub-year=2008 dt-pub=200812 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Toxin Production by Aeromonas sobria in Natural Environments: River Water vs. Seawater en-subtitle= kn-subtitle= en-abstract= kn-abstract=

Aeromonas are water-borne pathogens. They are halotolerant, which means that they can survive in environments whose salt content corresponds to that of seawater (3.0% NaCl). However, the presence of Aeromonas in seawater is extremely rare compared with that in river water. In this study, we tested the ability of Aeromonas sobria to produce toxins in river water and seawater. First, we cultured A. sobria on skim milk agar plates supplemented with either river water (SARW) or seawater (SASW). The bacteria grew on both plates. A clear zone around the bacteria was generated in SARW. However, such a zone was not observed in SASW, suggesting that proteases were not generated in SASW. Subsequently, we cultured A. sobria in a nutrient broth supplemented with either river water (NRW) or with seawater (NSW), and examined the protease activity of their culture supernatants. The protease activity of the culture supernatant from NSW was extremely low compared to that from NRW. The immunoblotting analysis showed that serine protease (ASP) was not produced by the culture in NSW. By contrast, aerolysin-like hemolysin was produced in all conditions examined in this study. This indicates that the salinity of water is deeply involved in the production of ASP by A. sobria.

en-copyright= kn-copyright= en-aut-name=KhanRasel en-aut-sei=Khan en-aut-mei=Rasel kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=TakahashiEizo en-aut-sei=Takahashi en-aut-mei=Eizo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakuraHironori en-aut-sei=Nakura en-aut-mei=Hironori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AnsaruzzamanMohammad en-aut-sei=Ansaruzzaman en-aut-mei=Mohammad kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=BanikSukalyani en-aut-sei=Banik en-aut-mei=Sukalyani kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=RamamurthyThandavarayan en-aut-sei=Ramamurthy en-aut-mei=Thandavarayan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=OkamotoKeinosuke en-aut-sei=Okamoto en-aut-mei=Keinosuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=Laboratory of Protein Function, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=2 en-affil= kn-affil=Laboratory of Protein Function, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=3 en-affil= kn-affil=Laboratory of Protein Function, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=4 en-affil= kn-affil=Laboratory Sciences Division, ICDDR, B (International Centre for Diarrhoeal Diseases Research, Bangladesh), Centre for Health and Population Research affil-num=5 en-affil= kn-affil=Laboratory of Protein Function, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences affil-num=6 en-affil= kn-affil=Collaborative Research Center of Okayama University for Infectious Diseases in India affil-num=7 en-affil= kn-affil=Laboratory of Protein Function, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences en-keyword=Aeromonas kn-keyword=Aeromonas en-keyword=water kn-keyword=water en-keyword=toxin kn-keyword=toxin en-keyword=salinity kn-keyword=salinity END start-ver=1.4 cd-journal=joma no-vol=52 cd-vols= no-issue= article-no= start-page=45 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=1982 dt-pub=19820325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The Effect of Thermal Spring Water on Drug Absorption in Special Reference to Aspirin and Indomethacin kn-title=‰·ò…ˆù—p‚Ì–ò•¨‹zŽû‚É‚¨‚æ‚Ú‚·‰e‹¿iƒCƒ“ƒhƒƒ^ƒVƒ“,ƒAƒXƒsƒŠƒ“‚Ìê‡j en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is thought that a drug reacts differently with media taken internally. The solubility of Aspirin is assured 600ƒÊg/ml in 30min. with Misasa spring water, whereas 400ƒÊg/ml with plain water. The parallel difference of 200ƒÊg/ml follows 10 min. thereafter. Maximum serum concentratin of 200ƒÊg/ml is obtained 2 hours after the internal use of Aspirin with Misasa spring water in parallel difference of 20ƒÊg/ml with plain water. In the case of Indomethacin intake, maximum serum concentration of 1.5ƒÊg/ml is obtained in 2 hours with plain water, whereas maximum serum concentration of 1ƒÊg/ml is obtained in the same period with Misasa spring water. However, the difference of 0.25ƒÊg/ml in serum concentration between the media internally taken is seen initially and after 4 hours under high concentration of Indomethacin. We, therefore, assume tentatively that the effect of Aspirin and Indomethacin is supposed to be enhanced with Misasa spring water taken internally. en-copyright= kn-copyright= en-aut-name=OkamotoTeruko en-aut-sei=Okamoto en-aut-mei=Teruko kn-aut-name=‰ª–{‹PŽq kn-aut-sei=‰ª–{ kn-aut-mei=‹PŽq aut-affil-num=1 ORCID= en-aut-name=HiranoMitsuhiro en-aut-sei=Hirano en-aut-mei=Mitsuhiro kn-aut-name=•½”öŒõG kn-aut-sei=•½”ö kn-aut-mei=ŒõG aut-affil-num=2 ORCID= en-aut-name=FurunoKatsushi en-aut-sei=Furuno en-aut-mei=Katsushi kn-aut-name=ŒÃ–쟎u kn-aut-sei=ŒÃ–ì kn-aut-mei=ŸŽu aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@ affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@ END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1-3 article-no= start-page=119 end-page=129 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of ATP on Hematopoietic Functions of Bone Marrow 3. Influences of ATP on Erythropoietic Functions of Rabbit, Normal Human and Hypoplastic Marrow kn-title=Adenosine triphosphate (ATP) ‚Ìœ‘‘¢ŒŒ‹@”\‚É‹y‚Ú‚·‰e‹¿‚ÉŠÖ‚·‚錤‹† ‘æ3•Ò œ‘‘gD”|—{‚ɉ—‚¯‚éÔŒŒ‹…Œn‘¢ŒŒ‹@”\‚É‹y‚Ú‚·‰e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of observing the influences of ATP on the bone marrow erythropoiesis, a roller tube culture method was used to cultivate bone marrow cell suspensions from normal rabbits, normal persons and patients with hypoplastic anemia. ATP solutions at various concentrations were added directly to the culture media and observations were carried out. As a result, it has been shown that addition of ATP resulted in an increase of erythrocytes, increase of hemoglobin content and increasing percentage of orthochromic erythroblasts. en-copyright= kn-copyright= en-aut-name=OkamotoMichio en-aut-sei=Okamoto en-aut-mei=Michio kn-aut-name=‰ª–{猒j kn-aut-sei=‰ª–{ kn-aut-mei=猒j aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1-3 article-no= start-page=113 end-page=118 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of ATP on Hematopoietic Functions of Bone Marrow 2. Influences of ATP on Thrombopoietic Functions of Guinea Pig, Normal Human and Hypoplastic Marrow kn-title=Adenosine triphosphate (ATP) ‚Ìœ‘‘¢ŒŒ‹@”\‚É‹y‚Ú‚·‰e‹¿‚ÉŠÖ‚·‚錤‹† ‘æ2•Ò œ‘‘gD”|—{‚ɉ—‚¯‚éð‹…Œn‘¢ŒŒ‹@”\‚É‹y‚Ú‚·‰e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to observe the influences of ATP on the bone marrow thrombopoiesis, clinical tissue culture of bone marrow from normal guinea pigs, normal persons and patients with hypoplastic anemia was conducted. ATP solutions at various concentrations were added directly to the culture media and observations were carried out to see effect of ATP on the functions of megakaryocytes of bone marrow. As a result, it has been seen that by adding an optimal amount of ATP the functions of megakaryocytes were accelerated. en-copyright= kn-copyright= en-aut-name=OkamotoMichio en-aut-sei=Okamoto en-aut-mei=Michio kn-aut-name=‰ª–{猒j kn-aut-sei=‰ª–{ kn-aut-mei=猒j aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=76 cd-vols= no-issue=1-3 article-no= start-page=105 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=1964 dt-pub=19640330 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Influences of ATP on Hematopoietic Functions of Bone Marrow 1. Influences of ATP on Leukopoietic Functions of Rabbit, Normal Human and Hypoplastic Marrow kn-title=Adenosine triphosphate (ATP)‚Ìœ‘‘¢ŒŒ‹@”\‚É‹y‚Ú‚·‰e‹¿‚ÉŠÖ‚·‚錤‹† ‘æ1•Ò œ‘‘gD”|—{‚ɉ—‚¯‚é”’ŒŒ‹…Œn‘¢ŒŒ‹@”\‚É‹y‚Ú‚·‰e‹¿ en-subtitle= kn-subtitle= en-abstract= kn-abstract=In order to observe the influences of ATP on the bone marrow leukopoiesis, clinical tissue culture of bone marrow from normal rabbits, normal persons and patients with hypoplastic anemia was conducted. ATP solutions at various concentrations were added directly to the culture media and observations were carried out to see effect of ATP on the functions of neutrophils of bone marrow. As a result, it has been demonstrated that by adding an optimal amount of ATP the ontgrowth, cell density and wandering velosity of neutrophils were increased. en-copyright= kn-copyright= en-aut-name=OkamotoMichio en-aut-sei=Okamoto en-aut-mei=Michio kn-aut-name=‰ª–{猒j kn-aut-sei=‰ª–{ kn-aut-mei=猒j aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw‘åŠw‰@ˆãŠwŒ¤‹†‰È END start-ver=1.4 cd-journal=joma no-vol=79 cd-vols= no-issue=11-12 article-no= start-page=947 end-page=956 dt-received= dt-revised= dt-accepted= dt-pub-year=1967 dt-pub=19671230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Immunofluorescent Studies on the Tumor Iuduced by Adenovirus Type 12 3. Sequential Observation on the local Carcinogenesis After Virus Inoculation to Newborn Hamsters kn-title=壌õR‘Ì–@‚É‚æ‚éƒAƒfƒmƒEƒBƒ‹ƒX12Œ^—U”­Žîᇂ̌Ÿõ 3. ƒEƒBƒ‹ƒXÚŽíŒã,”­Šà‚É“ž‚é–˜‚Ì‹ÇŠ•Ï‰»‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=By means of immunofluorescent technic, the author investigated the sequential changes of the viral antigens and tumor antigens in the tissue of newborn hamsters inoculated with adenovirus tyqe 12. 1. Subcutaneous inoculation Viral antigens could not already be found 4-5 hours after virus injection, but tumor antigens diffusely appeared in the injected part at least 24 hours later. In process of time, tumor antigens were gradually localized to the corium and muscle layer. Atypical large cells were recognized in the intermuscular bundles 15 days after inoculation, stained with strong, brilliant fluorescence. Histomorphologically they were identified with tumor cells originated from immature nerve-supporting cells which corresponded to muscle spindles or motor endplates. 2, Intraperitoneal inoculation Viral antigens could not almost be found 4-5 hours after injection, followed by appearance of tumor antigens 12-24 hours later. On the observation of the mesenterium tumor antigens also gradually localized and became more and more strongly stained on the nerve fibers, spindle shaped cells (probably schwann's cells) as well as ganglion cells. In 7-10 days after inoculation, small tumor nodules which showed bright fluorescence were found closely related with nerve fibers. On the other hand, the tumor antigens on the serosa cells became gradually weak and the degeneration of serosa cells was demonstrated after 3-7 days, which resembled cytopathic effect of infected HeLa-cells in vitro. 3. Intracranial inoculation Viral antigens disappeared more rapidly (one hour after virus inoculation) and tumor antigens were gradually located principally in the ependymal layer, meninx, but sometimes in the parenchyma of the brain which related to small blood vessels. Moreover, viral antigens were detected after three hours in the Kupffer cells of the liver and sinusendothelial cells of the spleen. en-copyright= kn-copyright= en-aut-name=OkamotoTsukasa en-aut-sei=Okamoto en-aut-mei=Tsukasa kn-aut-name=‰ª–{Ži kn-aut-sei=‰ª–{ kn-aut-mei=Ži aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ•a—Šw‹³Žº END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=7-8 article-no= start-page=527 end-page=534 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760830 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A report of field survey on acatalasemia and hypocatalasemia in 1972 and 1973 kn-title=º˜a47”N“x‚¨‚æ‚Ñ48”N“x Acatalasemia, Hypocatalasemia ’²¸WŒv en-subtitle= kn-subtitle= en-abstract= kn-abstract=The authors reported the results of field survey on acatalasemia and hypocatalasemia during the year of 1972 and 1973. Seventeen hypocatalasemias were seen in the test of 7,475 individuals at Oahu Is. of Hawaii, U.S.A. Among them two Englishmen, one Portugese and three Filipinos were included. One new acatalasemia case was reported in 1972. Consequently, the total of reported acatalasemias were 97 cases of 47 families by the end of 1973. en-copyright= kn-copyright= en-aut-name=TanakaTohru en-aut-sei=Tanaka en-aut-mei=Tohru kn-aut-name=“c’†“O kn-aut-sei=“c’† kn-aut-mei=“O aut-affil-num=1 ORCID= en-aut-name=TakaharaShigeo en-aut-sei=Takahara en-aut-mei=Shigeo kn-aut-name=‚Œ´Ž •v kn-aut-sei=‚Œ´ kn-aut-mei=Ž •v aut-affil-num=2 ORCID= en-aut-name=OguraYoshio en-aut-sei=Ogura en-aut-mei=Yoshio kn-aut-name=¬‘q‹`˜Y kn-aut-sei=¬‘q kn-aut-mei=‹`˜Y aut-affil-num=3 ORCID= en-aut-name=MasudaYu en-aut-sei=Masuda en-aut-mei=Yu kn-aut-name=‘“cŸà kn-aut-sei=‘“c kn-aut-mei=Ÿà aut-affil-num=4 ORCID= en-aut-name=ArakawaKiyoshi en-aut-sei=Arakawa en-aut-mei=Kiyoshi kn-aut-name=rì´ kn-aut-sei=rì kn-aut-mei=´ aut-affil-num=5 ORCID= en-aut-name=KasaiHideo en-aut-sei=Kasai en-aut-mei=Hideo kn-aut-name=Š}ˆä‰p•v kn-aut-sei=Š}ˆä kn-aut-mei=‰p•v aut-affil-num=6 ORCID= en-aut-name=TaniWataru en-aut-sei=Tani en-aut-mei=Wataru kn-aut-name=’JŒÝ kn-aut-sei=’J kn-aut-mei=ŒÝ aut-affil-num=7 ORCID= en-aut-name=ShibaKanji en-aut-sei=Shiba en-aut-mei=Kanji kn-aut-name=ŽÅŠ¤Ži kn-aut-sei=ŽÅ kn-aut-mei=Š¤Ži aut-affil-num=8 ORCID= en-aut-name=KurodaYasuo en-aut-sei=Kuroda en-aut-mei=Yasuo kn-aut-name=•“c‘׶ kn-aut-sei=•“c kn-aut-mei=‘׶ aut-affil-num=9 ORCID= en-aut-name=OkamotoKaneko en-aut-sei=Okamoto en-aut-mei=Kaneko kn-aut-name=‰ª–{‚©‚ËŽq kn-aut-sei=‰ª–{ kn-aut-mei=‚©‚ËŽq aut-affil-num=10 ORCID= en-aut-name=OhkuraKoji en-aut-sei=Ohkura en-aut-mei=Koji kn-aut-name=‘å‘q‹»Ži kn-aut-sei=‘å‘q kn-aut-mei=‹»Ži aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº affil-num=8 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº affil-num=9 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº affil-num=10 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”Ž¨•@ˆôA‰È‹³Žº affil-num=11 en-affil= kn-affil=“Œ‹žˆã‰ÈŽ•‰È‘åŠwl—Þˆâ“`Œ¤‹óŽº END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=3-4 article-no= start-page=253 end-page=259 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study of the influence of air pollution on a human body by Flow-volume curve kn-title=ƒtƒ[ƒ{ƒŠƒEƒ€‹Èü‚É‚æ‚é‘å‹C‰˜õ’n‹æ‚Ìl‘̉e‹¿’²¸ en-subtitle= kn-subtitle= en-abstract= kn-abstract=A comparative study of the influence of air pollution on a human body was made between 416 inhabitants in the air-polluted area and 291 inhabitants in the non-air-polluted area, aged 40 to 69, in Mizushima Industrial Area. The condition of air pollution in Mizushima Districts, except some districts, has changed for the better since September in 1973, so there were found less differences between the study and the control areas in both of the values of SO(2) concentration and NO(x) concentration. Accordingly, the incidence of a respiratory disease by air pollution was considered to have no significant difference in comparison with the control area. But, in the pulmonary function test, the values of V(50)/V(25) and V(25)/V(10), especially, by the flow-volume curve were high significantly in the fifties and the sixties of age of the study area. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= en-aut-name=MeguroTadamichi en-aut-sei=Meguro en-aut-mei=Tadamichi kn-aut-name=–Ú•’‰“¹ kn-aut-sei=–Ú• kn-aut-mei=’‰“¹ aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒöO‰q¶‹³Žº END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=119 end-page=124 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study of pulmonary function of chronic bronchitis in the air-polluted area and the non-air-polluted area kn-title=‘å‹C‰˜õ’n‹æ‚Æ”ñ‰˜õ’n‹æ‚Ì–«‹CŠÇŽx‰Š‚Ì”x‹@”\\ƒtƒ[ƒ{ƒŠƒEƒ€‹Èü‚ð’†S‚É‚µ‚Ä\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=A survey of a respiratory disease was performed among 1433 inhabitants in the air-polluted area, Mizushima Industrial Area, and 568 inhabitants in the non-air-polluted area. And the following results were obtained. The incidence rate of chronic bronchitis was higher in the air-polluted area. But the results on pulmonary function test by flow volume curve showed abnormality much more in cases of chronic bronchitis in the non-air-polluted area. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= en-aut-name=MeguroTadamichi en-aut-sei=Meguro en-aut-mei=Tadamichi kn-aut-name=–Ú•’‰“¹ kn-aut-sei=–Ú• kn-aut-mei=’‰“¹ aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶ affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒöO‰q¶‹³Žº END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=67 end-page=74 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pneumoconiosis caused by "sendo" dust and its environmental factor kn-title=‚¢‘õ“y‚¶‚ñ”x‚Æ‚»‚Ì”wŒi en-subtitle= kn-subtitle= en-abstract= kn-abstract=A survey of pneumoconiosis caused by "send" dust was performed on the rush-mat workers in Seno-cho and Hayashima-cho of Binan district, Okayama Prefecture. The results obtained were as follows: 1) Out of 199 rush-mat workers in Binan district (of whom, 163 subjects with working career of over 10 years in Seno-cho and 36 subjects with career of over 15 years in Hayashima-cho), 2 cases of P(3), 7 cases of P(1) and 6 cases of P(2) were found. 2) Pneumoconiosis due to "sendo" is clay pneumoconiosis and atypical silicosis caused by inhalation of the dust with free silica in low percentage (about 20%). And this disease shows its gradual development. As is evidenced by these, most of the cases of pneumoconiosis due to "sendo" were found in the workers with working career of over 20 years. 3) It was examined that 48.7% of "sendo" dust contained particles of under 5ƒÊ in diameter. And a higher incidence of pneumoconiosis due to "sendo" of fancy-mat workers among rush-mat workers was considered to be caused by indoor labor at the ill-ventilated workshop filled with a great deal of "sendo" dust. 4) Accordingly, as preventive measures against "sendo" dust, there needs the improvement of the environment in the workshop to install a ventilation and so on. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶Šw END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=59 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Report ‡T: A survey on polypropylene fancy-mat workers (in summer) kn-title=ƒ|ƒŠƒvƒƒsƒŒƒ“‰Ôä­D]‹ÆŽÒ‚ɂ‚¢‚Ä‚Ì2, 3‚Ì’²¸ ‘æ1•ñ i‰ÄŠú‚É‚¨‚¯‚é’²¸j en-subtitle= kn-subtitle= en-abstract= kn-abstract=Since about 1967, a polypropylene pipe that is 1.0mm in diameter has been used for weaving fancy mat in place of a rush. And the fancy-mat workers take extremely long working hours to weave it for the pursuit of profits. So, to clarify the relationship between the conditions of working and of their health, a survey was made on 118 workers (of whom, 52 males and 66 females) in 49 households in Seno-cho, Okayama Prefecture, in 1970. The results obtained were as follows: 1) As for the environment in the workshop, a noise level of weaving machines reached 80 phone. This value appeared to show the influence on the physical function of workers. 2) Admitted was want of sleeping hours among most of the workers because of irregular working hours, that is, over ten-hour labor a day (this contained 32.4% of the workers) and a working system of day-and-night shift. 3) Most of subjective fatigue complaints were the cases of chronic fatigue. The values of Donaggio's test of urine were high in 32.7% of the workers. 4) It was found mostly in the subjects of night-working type that values of Flicker descrimination varied more than 10% upward and found in the sujects of early-morning-working type that varied more than 10% downward. 5) As for the conditions of nutrition intake, it appeared that the side food was preferred to the staple food. This tendency is similar to an urban-type, though Seno-cho is located in a rural district. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶Šw END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=51 end-page=57 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Report ‡U: A survey on polypropylene fancy-mat workers (in winter) kn-title=ƒ|ƒŠƒvƒƒsƒŒƒ“‰Ôä­D]‹ÆŽÒ‚ɂ‚¢‚Ä‚Ì2, 3‚Ì’²¸ ‘æ2•ñ i“~Šú‚É‚¨‚¯‚é’²¸j en-subtitle= kn-subtitle= en-abstract= kn-abstract=In Report ‡T, the survey performed on the polypropylene fancy-mat workers in Seno-cho in summer was reported. And the following survey in winter was made on the same subjects on January in 1971. The results obtained were as follows: 1) It was found that 57.6% of the subjects worked for over ten hours a day, and this percentage was higher than in summer. 2) The number of subjective fatigue complaints offered by the workers was smaller in winter. 3) The number of the workers with high values in Donaggio's test of urine was increased in winter. 4) The incidence of low specific gravity of whole blood was higher because of longer working hours in winter. 5) Most of the cases of anemia were found in female workers (aged 28 to 52). These were iron deficiency hypochrome anemia. In these cases, it was observed that after recovery, the hemoglobin content of erythrocytes increased, while that there was no change in the number of erythrocytes. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶Šw END start-ver=1.4 cd-journal=joma no-vol=88 cd-vols= no-issue=1-2 article-no= start-page=1 end-page=7 dt-received= dt-revised= dt-accepted= dt-pub-year=1976 dt-pub=19760228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=On the counterplan for treatment of foul water which oozed out from a dumping ground kn-title=‚²‚Ý‚Ì–„—§ˆ—ê‚©‚ç‚ÌZo…‚̈—‘Îô en-subtitle= kn-subtitle= en-abstract= kn-abstract=The author reported generally on the tretment of foul water which oozed out from Makomodani (the valley of Makomo) of the dumping ground in Kurashiki City, Okayama Prefecture. And it is concluded that the most efficient counterplan for foul water pollution is to restrict laying and heaping up the garbage and to drain away the natural water of rain fall by its own passageway made for the rain, letting it not to stream in this Makomodani dumping ground. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶ END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue=7-8 article-no= start-page=863 end-page=868 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=197808 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Bacteriuria in the community by testape kn-title=ŽŽŒ±Ž†–@‚É‚æ‚éW’c‚Ì׋۔A‚̃XƒNƒŠ[ƒjƒ“ƒO¬Ñ‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the course of the screening examination of the adult diseases, 4959 inhabitants (both sex with age from 20 to 89 years) of communities in the south of Okayama Prefecture were examined bacteriuria with the nitrite testape (N-multisticks, Ames Co.) without cleaning pudenda from April to December, 1977, and the following results were obtained. 1) The rate of bacteriuria was 1.4% of the examinee, but the rate of bacteriuria of female (1.6% ) was 3.2 times higher than that of male (0.5% ). The rate by age of bacteriuria of male had single peak in his fifties, but that of female had bottom in her thirties, and after this age the rate rose with increasing age. 2) The cystitis of the urinary bladder or the kidney disease were the commonest disease among the past history of the cases, especially in female, with bacteriuria. About 1/4 of the cases with bacteriuria had complaints, and the pollakisuria was the commonest complaints (23.5% ). 3) The cases of bacteriuria complicated with albuminuria or occult blood were superior to that non-complicated in number, and the cases of glykosuria had bacteriuria to a high rate. 4) In 59.5% of the positive cases of the N-multisticks pyuria was observed microscopically in urinary sediments. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=Šp“ìd•v kn-aut-sei=Šp“ì kn-aut-mei=d•v aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠw affil-num=2 en-affil= kn-affil=ìèˆã‰È‘åŠw END start-ver=1.4 cd-journal=joma no-vol=90 cd-vols= no-issue=5-6 article-no= start-page=599 end-page=604 dt-received= dt-revised= dt-accepted= dt-pub-year=1978 dt-pub=19780630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Frequency of the occult blood in the urine in the community kn-title=W’c‚É‚¨‚¯‚é”AöŒŒ”½‰ž‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the course of the screening examination of the adult diseases, 2692 inhabitants of the community were examined the occult blood in the urine with N-multisticks (Ames Co.) from April to October, 1977, and the following results were obtained. 1) The positive rate of the occult blood in the urine was 16.3% of the examinee, but the rate of female (17.7%) was higher than that of male (12.0%), and the positive rate of the occult blood in the urine became higher with increase in age. 2) Following the cystitis of the urinary bladder the kidney disease was the most prevalent disease among the past history of the urinary tract diseases, and the pollakisuria was the commonest complaints. 3) In the positive cases of the occult blood in the urine, 93.4% of which was protein negative or questionable positive in the urine, but 6.6% of which was protein positive, and this group must have a precise examination. 4) In 61.8% of the positive cases of the occult blood in the urine, the hematuria was observed microscopically in the urinary sediments, and in 1.6% of the positive cases of the occult blood in the urine many cylinders were observed. From the above results, we concluded that it was necessary to add the occult blood examination to the urinary screening examination of the adult diseases. en-copyright= kn-copyright= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=1 ORCID= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=Šp“ìd•v kn-aut-sei=Šp“ì kn-aut-mei=d•v aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶ affil-num=2 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶ END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=9-10 article-no= start-page=1285 end-page=1293 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19771030 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Charactor of the Old Myocardial Infarctions found in the Mass Examinations in the Community kn-title=W’cŒŸf‚Å”­Œ©‚·‚é’nˆæ‚É‚¨‚¯‚é’‹Œ«S‹ØdÇ‚Ì“Á« en-subtitle= kn-subtitle= en-abstract= kn-abstract=Some cases, living a social life in the community, with the old myocardial infarctions found in the mass examinations concerning cardio-vascular diseases (performed by Department of Public Health, Kawasaki Medical School) were analysed for the purpose of finding the factors which regulate incidences and prognoses of the myocardial infarction, and the following results were obtained. 1) The average finding rate of the myocardial infarctions in 8 years was 0.37 % of the examinees. 2) The must conditions for being alive after myocardial infarctions, got from the studies of the 28 cases fond in 1975, were the following. (1) Most of them were attacked in their 50's or 60's. (2) Most of them had serum-cholesterol with normal level. (3) Two thirds of them were engaged in light or hard work. (4) Many of them had proteinuria. (5) They had almost no relation with glycosuria or obesity which had intimate relation with coronary insufficiency. en-copyright= kn-copyright= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=Šp“ìd•v kn-aut-sei=Šp“ì kn-aut-mei=d•v aut-affil-num=1 ORCID= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=2 ORCID= en-aut-name=WakimotoKazumasa en-aut-sei=Wakimoto en-aut-mei=Kazumasa kn-aut-name=˜e–{˜a¹ kn-aut-sei=˜e–{ kn-aut-mei=˜a¹ aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶ affil-num=2 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶ affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠw‹³—{•” en-keyword=‰ªŽRˆãŠw‰ï kn-keyword=‰ªŽRˆãŠw‰ï END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=1-2 article-no= start-page=115 end-page=119 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on the differences of values of examinees in mass examination of circulatory disease between the two continued years kn-title=zŠÂŠíW’cŒŸf‚ÌŒp‘±Žóf—á‚É‚¨‚¯‚鑪’è’l‚Ì•Ï“®‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=Statistical analyses of the differences of values of examinees, 8333 residents, in mass examination of circulatory disease between the two continued years were carried out and the following results were obtained. 1) The positive rates of proteinuria changed remarkably between the two years, but those of glucosuria did little or nothing, and were rather constant. 2) As 44.1 % of the cases who discontinued antihypertensive therapy had blood pressure under the borderline, so it was not always able to say, we thought that the therapy should not be discontinued. 3) The code number 4-6 of electrocardiography, which was not classified in Minesota code, seemed to be an important finding for the health control. en-copyright= kn-copyright= en-aut-name=NakamuraFumio en-aut-sei=Nakamura en-aut-mei=Fumio kn-aut-name=’†‘º•¶—Y kn-aut-sei=’†‘º kn-aut-mei=•¶—Y aut-affil-num=1 ORCID= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=2 ORCID= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=Šp“ìd•v kn-aut-sei=Šp“ì kn-aut-mei=d•v aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶ affil-num=2 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶ affil-num=3 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶ END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=1-2 article-no= start-page=109 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Geographical study on the mortality from diabetes mellitus: Comparison with body weights of pupils kn-title=“œ”A•aŽ€–S‚Ì’n—“IŠÏŽ@ Šw“¶,¶“k‚Ì‘Ìd‚Æ‚ÌŠÖŒW‚ɂ‚¢‚Ä en-subtitle= kn-subtitle= en-abstract= kn-abstract=To know the distribution of the mortality from diabetes mellitus in Japan and the factors concerned of it, the age-adjusted death rates of diabetes mellitus in each prefecture were calculated by indirect method in the triennial periods of 1969-71, and correlations between the death rates and the average body weights of pupils in each prefecture were studied. Significant correlations between the age-adjusted death rates in 1969-71 and those in 1963-67, 1958-62, and 1953-57 were recognized, and significant correlations were also recognized between the age-adjusted death rates of males and those of females, so prefecture-accumulations of the death rates were recognized. Significant correlations of the average body weights of pupils between 17 years on one hand and 12, and 8 years on the other in 1968 and 1959 were recognized, and constancies of the body weights by prefecture in terms of sex and time were seen. As the correlations between the age-adjusted death rates of diabetes mellitus in 1969-71 and the average body weights of pupils in 1968 and 1959 were significant, the prefecture-accumulations of the death rates of diabetes mellitus seemed to have ralations with the body weights of pupils, and the nutrition of the community. en-copyright= kn-copyright= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=Šp“ìd•v kn-aut-sei=Šp“ì kn-aut-mei=d•v aut-affil-num=1 ORCID= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=2 ORCID= en-aut-name=YasunagaKayoko en-aut-sei=Yasunaga en-aut-mei=Kayoko kn-aut-name=ˆÀ‰i‰Á‘ãŽq kn-aut-sei=ˆÀ‰i kn-aut-mei=‰Á‘ãŽq aut-affil-num=3 ORCID= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=•û³–¼ kn-aut-sei=•û kn-aut-mei=³–¼ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶Šw‹³Žº affil-num=2 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶Šw‹³Žº affil-num=3 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶Šw‹³Žº affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒöO‰q¶Šw‹³Žº END start-ver=1.4 cd-journal=joma no-vol=89 cd-vols= no-issue=1-2 article-no= start-page=51 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=1977 dt-pub=19770228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study by literatures on the changes in the mortality from diabetes mellitus kn-title=‚킪‘‚Ì“œ”A•aŽ€–S‚Ì„ˆÚ‚ÉŠÖ‚·‚镶Œ£“IlŽ@ en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose of studying the recent changes in the mortality from diabetes mellitus the crude death rates and the sex-age-specific death rates from diabetes mellitus obtained from Vital Statistics in Japan and the prevalences of diabetes mellitus obtained from Patients Investigation in Japan were analysed. The age-adjusted death rates were calculated from 1950 to 1974 by means of direct method on the basis of sex-specific population in Japan in 1935. 1) The crude death rates and the age-adjusted death rates from diabetes mellitus showed some increases by years, and those death rates of females were superiorr to those of males. 2) The death rates from diabetes mellitus of young people (15-29 years of age) had tendencies to decrease by years, on the contrary those of old people had tendencies to increase by years. The age-specific death rates of females were superior to those of males till the age of 34, but after the age of 35 the death rates of males were superior to those of females. 3) The average sex-age-specific death rates in 1950-54 had a step at the age of 20-29 years, and this disappeared almost in 1970-74. 4) The prevalences of diabetes mellitus from 1965 to 1973 showed increases at the age of 25-64 years, but those increases were not recognized at the age of 20-24 years. The prevalences of diabetes mellitus of males were superior to those of females. The death rate-prevalence ratios of diabetes mellitus showed some decreases at the age of 25-64 years, but those decreases were not recognized at the age of 20-24 years. en-copyright= kn-copyright= en-aut-name=SunamiShigeo en-aut-sei=Sunami en-aut-mei=Shigeo kn-aut-name=Šp“ìd•v kn-aut-sei=Šp“ì kn-aut-mei=d•v aut-affil-num=1 ORCID= en-aut-name=OkamotoTadashi en-aut-sei=Okamoto en-aut-mei=Tadashi kn-aut-name=‰ª–{³ kn-aut-sei=‰ª–{ kn-aut-mei=³ aut-affil-num=2 ORCID= en-aut-name=YasunagaKayoko en-aut-sei=Yasunaga en-aut-mei=Kayoko kn-aut-name=ˆÀ‰i‰Á‘ãŽq kn-aut-sei=ˆÀ‰i kn-aut-mei=‰Á‘ãŽq aut-affil-num=3 ORCID= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=•û³–¼ kn-aut-sei=•û kn-aut-mei=³–¼ aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶Šw‹³Žº affil-num=2 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶Šw‹³Žº affil-num=3 en-affil= kn-affil=ìèˆã‰È‘åŠwŒöO‰q¶Šw‹³Žº affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒöO‰q¶Šw‹³Žº END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=1-2 article-no= start-page=115 end-page=125 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A case of multiple hemangioma developing in the oral cavity and somatically kn-title=Œûo—̈您‚æ‚Ñ‘Sg‚É‘½”­‚µ‚½ŒŒŠÇŽî‚Ì1—á en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hemangioma is a benign tumor composed of vascular tissue which occurs in various parts of the body. In the oral area, it occurs preferentially in soft tissues such as the tongue, lips and buccal mucosa, and in rare cases it is said to develop even in the mandible. However, most cases are solitary and the development of multiple hemangioma all over the body is rare. We report a case of a girl aged 3 years and 5 months with multiple hemangioma in the oral cavity and all over the body. Treatment consisted of injection of sclerosing agents (Sodium Morrhuate), packing, and cryosurgery. The postoperative course was favorable with some reduction in the size of the tumors. en-copyright= kn-copyright= en-aut-name=NagahataShunichiro en-aut-sei=Nagahata en-aut-mei=Shunichiro kn-aut-name=’·”©xˆê˜Y kn-aut-sei=’·”© kn-aut-mei=xˆê˜Y aut-affil-num=1 ORCID= en-aut-name=OkamotoYoshimitsu en-aut-sei=Okamoto en-aut-mei=Yoshimitsu kn-aut-name=‰ª–{‘Sˆò kn-aut-sei=‰ª–{ kn-aut-mei=‘Sˆò aut-affil-num=2 ORCID= en-aut-name=KobayashiSeishi en-aut-sei=Kobayashi en-aut-mei=Seishi kn-aut-name=¬—Ñ´Ži kn-aut-sei=¬—Ñ kn-aut-mei=´Ži aut-affil-num=3 ORCID= en-aut-name=MatsumuraKazuyoshi en-aut-sei=Matsumura en-aut-mei=Kazuyoshi kn-aut-name=¼‘º˜a—Ç kn-aut-sei=¼‘º kn-aut-mei=˜a—Ç aut-affil-num=4 ORCID= en-aut-name=KochiHiroyoshi en-aut-sei=Kochi en-aut-mei=Hiroyoshi kn-aut-name=‚’mGŠì kn-aut-sei=‚’m kn-aut-mei=GŠì aut-affil-num=5 ORCID= en-aut-name=MonzenMoshiho en-aut-sei=Monzen en-aut-mei=Moshiho kn-aut-name=–å‘Oƒ‚ƒVƒz kn-aut-sei=–å‘O kn-aut-mei=ƒ‚ƒVƒz aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒûoŠO‰ÈŠw‹³Žº affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒûoŠO‰ÈŠw‹³Žº affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒûoŠO‰ÈŠw‹³Žº affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒûoŠO‰ÈŠw‹³Žº affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒûoŠO‰ÈŠw‹³Žº affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒûoŠO‰ÈŠw‹³Žº en-keyword=Œûo“à“î‘gD kn-keyword=Œûo“à“î‘gD en-keyword=‘½”­«ŒŒŠÇŽî kn-keyword=‘½”­«ŒŒŠÇŽî END start-ver=1.4 cd-journal=joma no-vol=91 cd-vols= no-issue=1-2 article-no= start-page=47 end-page=76 dt-received= dt-revised= dt-accepted= dt-pub-year=1979 dt-pub=19790228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study on vascularization of oral mucosal graft after transplantation kn-title=Œûo”S–Œ‚Ö‚Ì”S–ŒˆÚAŒã‚ÌŒŒŠÇV¶‚ÉŠÖ‚·‚éŽÀŒ±“IŒ¤‹† en-subtitle= kn-subtitle= en-abstract= kn-abstract=Damage inflicted on the oral mucosa may result in the development of an unfavorable appearance, functional disturbances, or growth retardation in the buccal-oral cavity region. In an attempt to minimize such disturbances, transplantation of the free oral mucosa was investigated. Changes in the vascular picture were studied by the intravascular injection of chloropercha. Three-dimensional and morphological observations of blood vessels were supported by macroscopical and pathohistological studies. The animals used were 60 adult dogs weighing about 4-8 kg raised in similar conditions. The left and right buccal mucosal flaps and the left and right maxillary third incisors served as the material. Intravenous anesthesia was used. In Exp. 1: a 1.0 x 1.0 cm piece was taken from the left buccal mucosa. A mucosal graft of the same size was obtained from the right buccal mucosa (used for the free buccal mucosa transplantation). In Exp. 2: the right buccal mucosa from which the mucosal flap had been taken was left as an open wound. In Exp. 3: a gingival section (1.0 x 1.0 cm) was taken from both sides of the maxillary gingiva at the level of the third maxillary incisors. A free buccal gingival graft was prepared from the left side and transplanted to the open wound on the right. The free buccal gingival graft from the right side was transplanted to the open wound on the left. 1) In the free buccal mucosal transplantation to the buccal mucosa, slight intrusion of blood vessels into the transplant was obvious 2 days after transplantation. By the fifth day many blood vessels had developed, by the sixth day these blood vessels formed a loop in the epithelial region, by the fourteenth day the arrangement of blood vessels had become well arrayed, and by the twentieth day blood vessels gave the same appearance as vessels in the transplantation bed. 2) Transplantation of the free mucosa on to the buccal mucosa of the opposite side gives better healing than leaving the damaged buccal mucosa as an open wound. 3) With transplantation of free gingiva to the gingiva of tooth neck, blood vessels had partially advanced into the transplant by the fifth post-operative day. By the tenth day, loop formation of vessels on the gingival epithelium together with gingival adhesion were well arranged. By the fortyfifth day, blood vessels in the transplant presented a similar picture to the normal. 4) Gingival transplantation to gingiva of the tooth neck gave better healing than buccal mucosal transplantation. Moreover, the appearance after operation was more satisfying. 5) The pathohistological findings for this vascular picture agreed in general with the macroscopic appearance. en-copyright= kn-copyright= en-aut-name=OkamotoYoshimitsu en-aut-sei=Okamoto en-aut-mei=Yoshimitsu kn-aut-name=‰ª–{‘Sˆò kn-aut-sei=‰ª–{ kn-aut-mei=‘Sˆò aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”ŒûoŠO‰ÈŠw‹³Žº en-keyword=–j”S–ŒˆÚA kn-keyword=–j”S–ŒˆÚA en-keyword=Ž•“÷ˆÚA kn-keyword=Ž•“÷ˆÚA en-keyword=”S–ŒˆÚA kn-keyword=”S–ŒˆÚA en-keyword=Œûo”S–Œ kn-keyword=Œûo”S–Œ en-keyword=ŒŒŠÇV¶ kn-keyword=ŒŒŠÇV¶ END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090325 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ƒVƒ“ƒoƒXƒ^ƒ`ƒ“‚É‚æ‚éƒqƒgŽ•‘Š²×–E‚ÌÛ‰å‰è×–E•ª‰»‘£i kn-title=Simvastatin induces the odontogenic differentiation of human dental pulp stem cells (DPSCs) in vitro and in vivo en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OkamotoYosuke en-aut-sei=Okamoto en-aut-mei=Yosuke kn-aut-name=‰ª–{—m‰î kn-aut-sei=‰ª–{ kn-aut-mei=—m‰î aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=1-2 article-no= start-page=107 end-page=112 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860228 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Duplicate foreign bodies in the airway and gastrointestinal tract: Report of a case kn-title=‹C“¹EH“¹‚É•ª—£‚µ‚½d•¡ˆÙ•¨Ç—á \‹³ŽºˆÙ•¨“Œv‚Æ•¶Œ£“IlŽ@\ en-subtitle= kn-subtitle= en-abstract= kn-abstract=A case of having two or more foreign bodies simultaneously in the airway and gastrointestinal tract is rare. The authors reported a case of two foreign bodies. A 54-year-old man who carelessly swallowed thumbtacks visited our clinic. An X-ray examination revealed thumbstack in the right bronchus and another in the stomach. The former was removed with a ventilation bronchoscope, and the latter was excreted spontaneously 2 days later. The authors have experienced 84 cases of esophageal foreign bodies and 47 cases of tracheobroncheal ones in the last 10 years. Cases of foreign bodies in both locations showed a higher frequency in males, and the majority of the cases were of children 3 years old or less. Coins were the most common esophageal foreign body, and peanuts were most common tracheobroncheal foreign body.The most frequent location of the foreign bodies was the cervical constriction in cases of esophageal foreign bodies, being twice as frequent as the right bronchus. Two cases of multiple foreign bodies have been treated in our clinic, and both of them were of 2 coins in the upper esophagus. en-copyright= kn-copyright= en-aut-name=SuehiroMichio en-aut-sei=Suehiro en-aut-mei=Michio kn-aut-name=––L—Ï—Y kn-aut-sei=––L kn-aut-mei=—Ï—Y aut-affil-num=1 ORCID= en-aut-name=UedaSetsuo en-aut-sei=Ueda en-aut-mei=Setsuo kn-aut-name=ã“cß•v kn-aut-sei=ã“c kn-aut-mei=ß•v aut-affil-num=2 ORCID= en-aut-name=IshiharaMotomasa en-aut-sei=Ishihara en-aut-mei=Motomasa kn-aut-name=ÎŒ´Šî³ kn-aut-sei=ÎŒ´ kn-aut-mei=Šî³ aut-affil-num=3 ORCID= en-aut-name=TomotsuTakao en-aut-sei=Tomotsu en-aut-mei=Takao kn-aut-name=èےî•v kn-aut-sei=èÛ’Ã kn-aut-mei=®•v aut-affil-num=4 ORCID= en-aut-name=OkamotoHiroshi en-aut-sei=Okamoto en-aut-mei=Hiroshi kn-aut-name=‰ª–{GŽi kn-aut-sei=‰ª–{ kn-aut-mei=GŽi aut-affil-num=5 ORCID= en-aut-name=TasakaShuji en-aut-sei=Tasaka en-aut-mei=Shuji kn-aut-name=“câŽüŽ¡ kn-aut-sei=“câ kn-aut-mei=ŽüŽ¡ aut-affil-num=6 ORCID= en-aut-name=TamuraShintaro en-aut-sei=Tamura en-aut-mei=Shintaro kn-aut-name=“c‘ºTˆê˜Y kn-aut-sei=“c‘º kn-aut-mei=Tˆê˜Y aut-affil-num=7 ORCID= en-aut-name=NanbaMasayuki en-aut-sei=Nanba en-aut-mei=Masayuki kn-aut-name=“ï”g³s kn-aut-sei=“ï”g kn-aut-mei=³s aut-affil-num=8 ORCID= en-aut-name=MasudaYu en-aut-sei=Masuda en-aut-mei=Yu kn-aut-name=‘“cŸà kn-aut-sei=‘“c kn-aut-mei=Ÿà aut-affil-num=9 ORCID= en-aut-name=OguraYoshio en-aut-sei=Ogura en-aut-mei=Yoshio kn-aut-name=¬‘q‹`˜Y kn-aut-sei=¬‘q kn-aut-mei=‹`˜Y aut-affil-num=10 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwŽ¨•@ˆôA‰ÈŠw‹³Žº affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwŽ¨•@ˆôA‰ÈŠw‹³Žº affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwŽ¨•@ˆôA‰ÈŠw‹³Žº affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwŽ¨•@ˆôA‰ÈŠw‹³Žº affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwŽ¨•@ˆôA‰ÈŠw‹³Žº affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwŽ¨•@ˆôA‰ÈŠw‹³Žº affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠwŽ¨•@ˆôA‰ÈŠw‹³Žº affil-num=8 en-affil= kn-affil=‰ªŽR‘åŠwŽ¨•@ˆôA‰ÈŠw‹³Žº affil-num=9 en-affil= kn-affil=‰ªŽR‘åŠwŽ¨•@ˆôA‰ÈŠw‹³Žº affil-num=10 en-affil= kn-affil=‰ªŽR‘åŠwŽ¨•@ˆôA‰ÈŠw‹³Žº en-keyword=‹C“¹ kn-keyword=‹C“¹ en-keyword=H“¹ kn-keyword=H“¹ en-keyword=d•¡ˆÙ•¨ kn-keyword=d•¡ˆÙ•¨ en-keyword=ˆÙ•¨“Œv kn-keyword=ˆÙ•¨“Œv END start-ver=1.4 cd-journal=joma no-vol=35 cd-vols= no-issue=1-2 article-no= start-page=21 end-page=28 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20010327 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Laser Welding of Slices of Magnetic Circuit en-subtitle= kn-subtitle= en-abstract= kn-abstract=In electric power industry, there is a problem of achieving stable joint in different components using high productive and efficient technologies. One type of these components is packages of slices for magnetic circuit of electric motors, transformers etc., which need reliable means for their fixing. Laser welding is proposed to solve this problem as an alternative for existing technologies. The development of the laser welding process is presented based on process simulation, study of heat history and comparison with experimental results. Laser beam additional scanning technique is proposed to improve the quality and efficiency of the joining operation. en-copyright= kn-copyright= en-aut-name=S.kovalenkoVolodymyr en-aut-sei=S.kovalenko en-aut-mei=Volodymyr kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=UnoYoshiyuki en-aut-sei=Uno en-aut-mei=Yoshiyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkamotoYasuhiro en-aut-sei=Okamoto en-aut-mei=Yasuhiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=AnyakinM. en-aut-sei=Anyakin en-aut-mei=M. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=LutayA. en-aut-sei=Lutay en-aut-mei=A. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=ShubulKhaled Al. en-aut-sei=Shubul en-aut-mei=Khaled Al. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Department of Mechanical Engineering (Now at Laser Technology Research Institute, National Technical affil-num=2 en-affil= kn-affil=Department of Mechanical Engineering affil-num=3 en-affil= kn-affil=Department of Mechanical Engineering affil-num=4 en-affil= kn-affil=Laser Technology Research Institute, National Technical University of Ukraine affil-num=5 en-affil= kn-affil=Laser Technology Research Institute, National Technical University of Ukraine affil-num=6 en-affil= kn-affil=Laser Technology Research Institute, National Technical University of Ukraine END start-ver=1.4 cd-journal=joma no-vol=7 cd-vols= no-issue=2 article-no= start-page=99 end-page=103 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970131 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=•ÏŒ`«•GŠÖ߉ŠŠ³ŽÒ•GŠÖ߉t’†‚Ì×–EŠOƒ}ƒgƒŠƒbƒNƒX¬•ª‚Ɖ—n«VCAM-1 kn-title=Extracellular matrix components and soluble VCAM-1 in synovial fluid with osteoarthritis of the knee en-subtitle= kn-subtitle= en-abstract=•ÏŒ`«•GŠÖ߉Š(OA)Š³ŽÒ‚Í,‚—ŽÐ‰ï‚Ì“ž—ˆ‚Æ‚Æ‚à‚É¡Œã‚Ü‚·‚Ü‚·‘‰Á‚·‚é‚à‚Ì‚Æl‚¦‚ç‚ê‚é¡OA‚Ì”­ÇƒƒJƒjƒYƒ€‚ɂ‚¢‚Ä‚Í,ŠÖߓ̔j‰ó¥C•œ‚âƒpƒ“ƒkƒXŒ`¬‚ÉŠÖ‚í‚鑽‚­‚ÌŠÖ˜AˆöŽq(ƒTƒCƒgƒJƒCƒ“,ƒ}ƒgƒŠƒbƒNƒX•ª‰ðy‘f,•ª‰ðy‘f—}§ˆöŽq,ƒvƒƒeƒIƒOƒŠƒJƒ“,Šˆ«Ž_‘f,×–EÚ’…ˆöŽq‚È‚Ç)‚ɂ‚¢‚Ä,‘½–Ê“I‚ÉŒ¤‹†‚ªi‚ñ‚Å‚¢‚é¡‚µ‚©‚µ,•GŠÖ߂̉ŠÇ‰Šú‚Ì•a‘Ԃ̃ƒJƒjƒYƒ€‚ɂ‚¢‚Ä‚Í,‚È‚¨Úׂɉ𖾂³‚ê‚Ä‚¨‚炸,ŠÖ߉Š‰Šú‚̉ŠÇŽw•W‚ÌŒŸõ‚ª¡Œã‚³‚ç‚É•K—v‚Æl‚¦‚ç‚ê‚é¡–{Œ¤‹†‚ÅŽ„‚½‚¿‚Í, OAŠ³ŽÒ•GŠÖ߉t’†‚Ì×–EŠOƒ}ƒgƒŠƒbƒNƒX\¬¬•ª‚Å‚ ‚éƒRƒ‰[ƒQƒ“,‚Öƒpƒ‰ƒ“—°Ž_ƒvƒƒeƒIƒOƒŠƒJƒ“,ƒEƒƒ“Ž_‚¨‚æ‚щŠÇ‚ÌÅ‚à‰Šú‚ÉŒŒŠÇ“à”ç×–E‚ÉoŒ»‚·‚éVCAM-1“™‚̉—n‰»¬•ª”Z“x‚𑪒肵‚½¡Š³ŽÒ•GŠÖ߉t(SF)’†‚̉—n«ƒRƒ‰[ƒQƒ“—ʂƉ—n«VCAM-1(sVCAM-1)—Ê‚Æ‚Í—LˆÓ‚ȳ‚Ì‘ŠŠÖŠÖŒW‚ª(ƒÏ=0.652)ŠÏŽ@‚³‚ꂽ¡‚µ‚©‚µ,ƒwƒpƒ‰ƒ“—°Ž_ƒvƒƒeƒIƒOƒŠƒJƒ“(HSPG)‚Ɖ—n«ƒRƒ‰[ƒQƒ“(sCOLL)’lŠÔ‚É‚Í—LˆÓ‚È‘ŠŠÖŠÖŒW‚ÍŠm”F‚³‚ê‚È‚©‚Á‚½¡‚Ü‚½,ˆê”ʂɉŠÇ‚ÌŽw•W‚Æ‚µ‚Ä—p‚¢‚ç‚ê‚éCRP’l‚Æ‚à”䌌Ÿ“¢‚µ‚½‚ª,CRP’l‚Æ‘¼‚Ì‘ª’耖ڒl‚Ƃ͈ê’è‚Ì‘ŠŠÖŠÖŒW‚Í‘¶Ý‚µ‚È‚©‚Á‚½BˆÈã‚ÌŒ‹‰Ê‚æ‚è,OAŠ³ŽÒ‚ÌSF’†‚̉ŠÇƒ}[ƒJ-‚Æ‚µ‚Ä,‹}«‰ŠÇŽž‚É‚Í]—ˆ‚̉ŠÇŽw•W’`”’Ž¿‚Å‚ ‚éCRP’l‚ª—L—Í‚Å‚ ‚é‚Æ‚¢‚¤Sipe JD‚Ì•ñ‚©‚ç„‘ª‚·‚é‚ÆsCOLL‚ÆsVCAM-1‚ÍCRP’l‚ƈê’è‚Ì‘ŠŠÖ‚ðŽ¦‚³‚È‚¢‚±‚Æ‚æ‚è,CRP‚Ì“®‘ԂƂ͈قȂÁ‚½‰ŠÇŽw•W‚Æ‚µ‚Ä‚Ì—L—p«‚ªl‚¦‚ç‚ê‚é¡‚µ‚©‚µ,HSPG‚̓Gƒ“ƒhƒTƒCƒgƒVƒX‚É‚æ‚葬‚â‚©‚É‘ãŽÓ‚³‚ê‚邽‚ßSF’†‚ւ̉𗣂ª­‚È‚­,‰ŠÇŽw•W‚Æ‚µ‚Ẳ”\«‚Í’á‚¢‚Æl‚¦‚ç‚ê‚é¡ kn-abstract=It is generally accepted that the number of patients with osteoarthritis (OA) of the knee must increase in the future because of the increase of the aged. The pathogenic mechanisms of OA haven't been elucidated yet, but it is supposed that mediate pannus may cause the factors for irreversible cartilage damage in the inflammatory process. Therefore it is very important to find and predict OA at the early stage. Now there were many indices to determine joint damage with OA, for example, cytokines including IL, TNF, TGF, matrix metalloproteinase (MMPs), tissue inhibitor of metalloproteinase (TIMPs), proteoglycan (PG), hyaluronate (HA), super oxide, adhesion molecules including, ICAM-1, VCAM-1 and PECAM. In this study, we measured that the soluble VCAM-1 (sVCAM-1), soluble collagen (sCOLL), heparansulfate proteoglycan (HSPG), uronic acis and CRP in synovial fluids (SF) with OA. A positive correlation between the level of sVCAM-1 and sCOLL (ƒÏ = 0.652) was noted. However there was no factor showing a correlation with CRP. It was suggested that the levels of sVCAM-1 and sCOLL in the synovia fluid were active inflammation indices of knee damage, as the different aspects from CRP. The level of HSPG also showed a unique trend because HSPG on the cell surface was quickly digested endocytosis, so that it was not suitable for the inflammatory index in synovial fluid with OA. en-copyright= kn-copyright= en-aut-name=TohgeHiroko en-aut-sei=Tohge en-aut-mei=Hiroko kn-aut-name=“‚‰º”ŽŽq kn-aut-sei=“‚‰º kn-aut-mei=”ŽŽq aut-affil-num=1 ORCID= en-aut-name=IchimuraMitsuko en-aut-sei=Ichimura en-aut-mei=Mitsuko kn-aut-name=ˆê‘ºŒõŽq kn-aut-sei=ˆê‘º kn-aut-mei=ŒõŽq aut-affil-num=2 ORCID= en-aut-name=SakiyamaJunko en-aut-sei=Sakiyama en-aut-mei=Junko kn-aut-name=èŽR‡Žq kn-aut-sei=èŽR kn-aut-mei=‡Žq aut-affil-num=3 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=‰ª–{Šî kn-aut-sei=‰ª–{ kn-aut-mei=Šî aut-affil-num=4 ORCID= en-aut-name=NakataYasunari en-aut-sei=Nakata en-aut-mei=Yasunari kn-aut-name=’†“cˆÀ¬ kn-aut-sei=’†“c kn-aut-mei=ˆÀ¬ aut-affil-num=5 ORCID= en-aut-name=EndoHiroshi en-aut-sei=Endo en-aut-mei=Hiroshi kn-aut-name=‰““¡_ kn-aut-sei=‰““¡ kn-aut-mei=_ aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È en-keyword=•ÏŒ`«•GŠÖ߉Š (Osteoarthritis) kn-keyword=•ÏŒ`«•GŠÖ߉Š (Osteoarthritis) en-keyword=×–EŠOƒ}ƒgƒŠƒbƒNƒX (Extracellular matrix) kn-keyword=×–EŠOƒ}ƒgƒŠƒbƒNƒX (Extracellular matrix) en-keyword=‰Â—n«VCAM-1 (Soluble VCAM-1) kn-keyword=‰Â—n«VCAM-1 (Soluble VCAM-1) en-keyword=‰Â—n«ƒRƒ‰[ƒQƒ“ (Soluble Collagen) kn-keyword=‰Â—n«ƒRƒ‰[ƒQƒ“ (Soluble Collagen) en-keyword=‰Â—n«ƒwƒpƒ‰ƒ“—°Ž_ƒvƒƒeƒIƒOƒŠƒJƒ“ (Soluble HSPG) kn-keyword=‰Â—n«ƒwƒpƒ‰ƒ“—°Ž_ƒvƒƒeƒIƒOƒŠƒJƒ“ (Soluble HSPG) END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=31 end-page=35 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Correlative study of hippocampal atrophy assessed by MRI and clinical features in temporal lobe epilepsy. kn-title=‘¤“ª—t‚Ä‚ñ‚©‚ñ‚ÌŠC”nˆÞk‚Æ—Õ°‘œ‚ÌŒŸ“¢ \MRI‚ð—p‚¢‚½ŠC”nˆÞk‚̊ȈՕ]‰¿\ en-subtitle= kn-subtitle= en-abstract=We studied hippocampal atrophy in 39 patients with temporal lobe epilepsy using MRI. The ratio (a) of the width of the hippocampus on the atrophic side to that on the contralateral side was measured in coronal sections of the short SE in MRI. According to this ratio, the patients were divided into three groups : 11 with hippocampal atrophy (a<0.8), 13 with borderline atrophy (0.8…a…0.9), and 15 with no hippocampal atrophy (a†0.8). In the patients of the group with hippocampal atrophy, the clinical history of epilepsy tended to be long, and the site of hippocampal atrophy was consistent with that of interictal spike foci on the electroencephalogram in 9 out of 11 patients. However, there was no difference between the three groups, with regard to age at onset, age when MRI was conducted, frequency of seizures, generalized seizures, the types and doses of antiepileptic drugs used, history of neonatal asphyxia, intelligence and epilpetic psychosis. These results suggest that hippocampal atrophy in temporal lobe epilepsy may be related to repetition of epileptic dischargges in a localized part of the brain. kn-abstract=‘¤“ª—t‚Ä‚ñ‚©‚ñŠ³ŽÒ39—á‚ÌŠC”nˆÞk‚ðMRI‚ð—p‚¢‚Ä•]‰¿‚µ,—Õ°‘œ‚Æ‚ÌŠÖ˜A‚ðŒŸ“¢‚µ‚½¡MRI‚ÌŠ¥ó’fshort SE‘œ‚ÅŠC”n‚Ì•‚ðŒv‘ª‚µ,ˆÞk‘¤ŠC”n‚Ì‘º‘¤ŠC”n‚ɑ΂·‚é”ä(a)‚ð‹‚ß,ŠC”nˆÞk(+)ŒQ;a<0.8,11—á,‹«ŠEŒQ;0.8…a<0.9,13—á,ŠC”nˆÞk(-)ŒQ;a†0.9,15—á‚Ì3ŒQ‚É•ª‚¯‚½¡ŠC”nˆÞk(+)ŒQ‚Åœë•aŠúŠÔ‚ª’·‚¢ŒXŒü‚ª‚ ‚Á‚½¡‚Ü‚½,”­ìŠÔŸ[Šú”]”g‚ÌÅ“_‘¤‚ÍŠC”nˆÏk(+)ŒQ‚Ì11—á’†9—á‚ňÞk‘¤‚ƈê’v‚µ‚½B‚µ‚©‚µ,”­•a”N—î,MRIŽB‰eŽž”N—î,”­ì•p“x,‘S”ʉ»”­ì‚Ì—L–³,R‚Ä‚ñ‚©‚ñ–ò‘•ž—p—Ê,’m”\áŠQ,¸_Çó,¶‰ºŽž‰¼Ž€‚Ì—L–³‚ɂ‚¢‚Ä‚Í3ŒQŠÔ‚Å·‚ª”F‚ß‚ç‚ê‚È‚©‚Á‚½¡‚±‚ÌŒ‹‰Ê‚©‚ç,‘¤“ª—t‚Ä‚ñ‚©‚ñ‚É‚¨‚¯‚éŠC”nˆÞk‚Í,¶‰ºŽž‚â‘Sg‚¯‚¢‚ê‚ñ”­ìŽž‚Ì’áŽ_‘fó‘Ô‚É‚æ‚é‚à‚Ì‚Å‚Í‚È‚­,”]‹ÇŠ‚Ì”½•œ‚·‚é‚Ä‚ñ‚©‚ñ«”­ŽË‚ÆŠÖ˜A‚·‚é‰Â”\«‚ªŽ¦´‚³‚ê,ŠC”nˆÞk‚Ì‹@˜‚ðl‚¦‚邤‚¦‚Å‹»–¡[‚­Žv‚í‚ꂽB en-copyright= kn-copyright= en-aut-name=SatoKeiko en-aut-sei=Sato en-aut-mei=Keiko kn-aut-name=²“¡Œ\Žq kn-aut-sei=²“¡ kn-aut-mei=Œ\Žq aut-affil-num=1 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=‰ª–{Šî kn-aut-sei=‰ª–{ kn-aut-mei=Šî aut-affil-num=2 ORCID= en-aut-name=JojaIkuo en-aut-sei=Joja en-aut-mei=Ikuo kn-aut-name=ã’…ˆè•v kn-aut-sei=ã’… kn-aut-mei=ˆè•v aut-affil-num=3 ORCID= en-aut-name=NakatsuTakeshi en-aut-sei=Nakatsu en-aut-mei=Takeshi kn-aut-name=’†’ÕŽu kn-aut-sei=’†’à kn-aut-mei=•Žu aut-affil-num=4 ORCID= en-aut-name=MorimotoKiyoshi en-aut-sei=Morimoto en-aut-mei=Kiyoshi kn-aut-name=X–{´ kn-aut-sei=X–{ kn-aut-mei=´ aut-affil-num=5 ORCID= en-aut-name=HayabaraToshiyuki en-aut-sei=Hayabara en-aut-mei=Toshiyuki kn-aut-name=‘Œ´•q”V kn-aut-sei=‘Œ´ kn-aut-mei=•q”V aut-affil-num=6 ORCID= en-aut-name=KurodaShigetoshi en-aut-sei=Kuroda en-aut-mei=Shigetoshi kn-aut-name=•“cd—˜ kn-aut-sei=•“c kn-aut-mei=d—˜ aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=‘—§—×{Š“쉪ŽR•a‰@_Œo“à‰È¥—Õ°Œ¤‹†•” affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•úŽËüˆãŠw‹³Žº affil-num=4 en-affil= kn-affil=‰ªŽRŽs—§Žs–¯•a‰@_Œo“à‰È affil-num=5 en-affil= kn-affil=ìˆã‰È‘åŠw_Œo¸_ˆãŠw‹³Žº affil-num=6 en-affil= kn-affil=‘—§—×{Š“쉪ŽR•a‰@_Œo“à‰È¥—Õ°Œ¤‹†•” affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”_Œo¸_ˆãŠw‹³Žº en-keyword=‘¤“ª—t‚Ä‚ñ‚©‚ñ (temporal lobe epilepsy) kn-keyword=‘¤“ª—t‚Ä‚ñ‚©‚ñ (temporal lobe epilepsy) en-keyword=ŠC”nˆÏk (hippocampal atrophy) kn-keyword=ŠC”nˆÏk (hippocampal atrophy) en-keyword=œë•aŠúŠÔ (clinical history) kn-keyword=œë•aŠúŠÔ (clinical history) en-keyword=MRI kn-keyword=MRI en-keyword=”­ìŠÔŸ[Šú”]”g (interictal EEG foci) kn-keyword=”­ìŠÔŸ[Šú”]”g (interictal EEG foci) END start-ver=1.4 cd-journal=joma no-vol=8 cd-vols= no-issue=1 article-no= start-page=23 end-page=29 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=19970910 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study on recording and analysis conditions of polysomnography for automated computer analysis of sleep stages. kn-title=‡–°ƒ|ƒŠƒOƒ‰ƒtŽ©“®‰ðÍ‚Ì‚½‚ß‚Ì‹L˜^¥‰ðÍðŒ‚ÌŒŸ“¢ en-subtitle= kn-subtitle= en-abstract=Recording and analysis conditions of polysomnography were examined in 10 young adult female by using sleep analysis computer Medilog SAC 847 system (Oxford). The quantity and percentage of slow wave sleep were consistent with those of visual inspection when the minimum delta amplitude was adjusted at } 25`31ƒÊV from the baseline. The gain amplitude of mandibular electromyogram dramatically affected recognition of REM stage by the computer. Percentage of REM sleep was almost same as that of visual inspection when the gain potentiometer was adjusted to read 50ƒÊV peak-to-peak calibration signal as 1.0V, while REM stage was not recognized when@the gain potentiometer was adjusted to 1.5V. In contrast, the gain amplitude of electropthalmogram@did not affect the recognition of REM stage. kn-abstract=Ž©“®‰ðÍ‘•’u‚ð—p‚¢‚ÄI–釖°ƒ|ƒŠƒOƒ‰ƒt‚ð‰ðÍ‚·‚éÛ‚Ì‹L˜^ðŒ‚ƉðÍðŒ‚ðŒŸ“¢‚µ‚½B‘ÎÛ‚ÍŽá”N¬l—«10–¼‚Å,‰ðÍ‚É‚Í0xfordŽÐ»‡–°ƒ|ƒŠƒOƒ‰ƒt‹L˜^¥‰ðÍ‘•’uMedilog SAC 847 System‚ð—p‚¢,‘æ3–é‚Ì‹L˜^‚ðŽ‹Ž@”»’è‚Æ”äŠr‚µ‚½¡™”g‡–°‚ÌŽw•W‚Æ‚È‚éƒÂ”g‚ÌŬU•Šî€‚ð‰ŠúÝ’è‚ÌŠîü‚©‚ç}31/ƒÊV‚Æ,‚±‚ê‚æ‚è’á‚¢}25/ƒÊV‚ÉÝ’è‚·‚é‚Æ,™”g‡–°—Ê,™”g‡–°—¦‚Æ‚àŽ‹Ž@‚É‚æ‚é”»’è‚Æ‚Ù‚Ú“¯‚¶‰ðÍŒ‹‰Ê‚ª“¾‚ç‚ꂽBŠá‹…‰^“®‚Ì“ü—ÍŠ´“x‚ÍREM‡–°—Ê,REM‡–°—¦‚ɉe‹¿‚µ‚È‚©‚Á‚½‚ª,ƒIƒgƒKƒC‹Ø“d}‚Ì“ü—ÍŠ´“x‚ð‰ŠúÝ’è‚Ì1.5V‚É‚·‚é‚ÆREM‡–°‚ª‚Ù‚Æ‚ñ‚Ç‚Ý‚ê‚È‚­‚È‚é—Ⴊ‘½‚­,1.0V‚Å‚ÍREM‡–°—Ê‚ª‚±‚ê‚Ü‚Å‚Ì•ñ‚æ‚è­‚È‚¢‚à‚Ì‚Ì,Ž‹Ž@”»’è‚É‹ß‚¢Œ‹‰Ê‚ª“¾‚ç‚ꂽ¡ˆÈã‚ÌŒ¤‹†Œ‹‰Ê‚©‚ç,‰äX‚ª—p‚¢‚½Ž©“®‰ðÍ‘•’u‚Å‚Í,ƒIƒgƒKƒC‹Ø“d}‚Ì“ü—ÍŠ´“x‚ð1.0V,ƒÂ”g‚ÌŬU•Šî€‚ð}25`31/ƒÊV‚ÉÝ’è‚·‚ê‚Î,Ž‹Ž@”»’è‚Æ‚Ù‚Ú“¯‚¶‰ðÍŒ‹‰Ê‚ª“¾‚ç‚ê‚é‚Æl‚¦‚ç‚ꂽ¡ en-copyright= kn-copyright= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=‰ª–{Šî kn-aut-sei=‰ª–{ kn-aut-mei=Šî aut-affil-num=1 ORCID= en-aut-name=InoueMakiko en-aut-sei=Inoue en-aut-mei=Makiko kn-aut-name=ˆäã^‹IŽq kn-aut-sei=ˆäã kn-aut-mei=^‹IŽq aut-affil-num=2 ORCID= en-aut-name=NakashimaMakiko en-aut-sei=Nakashima en-aut-mei=Makiko kn-aut-name=’†“‡–ƒ‹IŽq kn-aut-sei=’†“‡ kn-aut-mei=–ƒ‹IŽq aut-affil-num=3 ORCID= en-aut-name=ItoSekiko en-aut-sei=Ito en-aut-mei=Sekiko kn-aut-name=ˆÉ“¡ÌŽq kn-aut-sei=ˆÉ“¡ kn-aut-mei=ÌŽq aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆã—ËZp’ZŠú‘åŠw•”‰q¶‹ZpŠw‰È en-keyword=‡–° (sleep) kn-keyword=‡–° (sleep) en-keyword=I–éƒ|ƒŠƒOƒ‰ƒt (polysomnography) kn-keyword=I–éƒ|ƒŠƒOƒ‰ƒt (polysomnography) en-keyword=Ž©“®‰ðÍ (automated computer analysis) kn-keyword=Ž©“®‰ðÍ (automated computer analysis) en-keyword=‹L˜^ðŒ (recording conditions) kn-keyword=‹L˜^ðŒ (recording conditions) en-keyword=‰ðÍðŒ (analysis condition) kn-keyword=‰ðÍðŒ (analysis condition) END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=2 article-no= start-page=105 end-page=111 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ƒqƒXƒ`ƒWƒ“ƒ^ƒO‚ðŽ‚ƒzƒXƒtƒ@ƒJƒ“ƒRƒA’`”’‚Ì‘å’°‹Û‚Å‚Ì”­Œ»‚Ƹ» kn-title=Affinity purification of phosphacan core protein expressed in Escherichia coli as histidine-tagged fusion protein en-subtitle= kn-subtitle= en-abstract=ƒRƒ“ƒhƒƒCƒ`ƒ“—°Ž_ƒvƒƒeƒIƒOƒŠƒJƒ“‚̈ê‚‚ł ‚éƒzƒXƒtƒ@ƒJƒ“‚̃RƒA’`”’‚Ì“Á’è—̈æ‚ð,ƒqƒXƒ`ƒWƒ“ƒ^ƒO(His-tag)‚ðŽ‚—Z‡’`”’‚Æ‚µ‚Ä‘å’°‹Û“à‚Å”­Œ»‚³‚¹ƒjƒbƒPƒ‹-ƒjƒgƒŠƒ3|Ž_(Ni-NTA)ƒAƒtƒBƒjƒeƒB’S‘Ì‚ð—p‚¢‚ĸ»‚µ‚½¡ƒzƒXƒtƒ@ƒJƒ“ƒRƒA’`”’‚̃Aƒ~ƒmŽ_ŽcŠî343-446(P3)‹y‚Ñ1-340(P4)‚É‘Š“–‚·‚écDNA’f•Ð‚ð,‘Ù«18“ú–ڂ̃‰ƒbƒg”]—R—ˆ‚ÌmRNA‚ð’’Œ^‚Æ‚µ‚½PCR‚É‚æ‚Á‚Ä‘•‚µ‚½¡‘•‚³‚ꂽ’f•Ð‚Í”­Œ»ƒxƒNƒ^[pQE30‚É‘g‚Ýž‚Ü‚ê,‚±‚ê‚Å‘å’°‹Û(M15[pREP4])‚ðŒ`Ž¿“]Š·‚µ‚½¡His-tag—Z‡’`”’‚Ì”­Œ»‚ÍŒ`Ž¿“]Š·Š”‚ð1mM IPTG‘¶Ý‰º‚Å37Ž,5ŽžŠÔ”|—{‚·‚邱‚Æ‚É‚æ‚Á‚Äs‚í‚ꂽ¡His-tagged P3—Z‡’`”’‚͉—n«’`”’Ž¿‚Æ‚µ‚Ä”­Œ»‚µ,Ni-NTA’S‘Ì‚ð—p‚¢‚ĸ»‚³‚ꂽ.His-tagged P4—Z‡’`”’‚Í•s—n«‚Ì••“ü‘Ì‚ðŒ`¬‚µ‚½‚ª,8M”A‘f‚É‚æ‚Á‚ĉ—n‰»‚³‚ê,•Ï«ðŒ‰º‚Å“¯—l‚ɸ»‚³‚ꂽ¡ kn-abstract=Specific regions of core protein of phosphacan, one of the chondroitin sulfate proteoglycans, were expressed as fusion proteins with histidine-tag (His-tag) in Escherichia coli (E.coli) and were affinity purified using nickel-nitrilotriacetic acid (Ni-NTA) matrix. cDNA fragments encoding amino acid residues 343-446 (P3) and 1-340 (P4) of phosphacan core protein were amplified by polymerase chain reaction from E18 rat brain mRNA as template. The amplified products were subcloned into pQE30 vector and were introduced into E.coli strain M15 [pREP4] for the expression. The His-tagged fusion proteins were expressed by cultivating the transformants at 37Ž for 5h in the presence of 1mM IPTG. His-tagged P3 fusion protein (His-P3) was expressed as soluble form, and was purified using Ni-NTA matrix. His-tagged P4 fusion protein (His-P4) which was sequestered into insoluble inclusion bodies was treated with 8.0M urea to solubilize, and then was purified under denaturing conditions. en-copyright= kn-copyright= en-aut-name=ItoSekiko en-aut-sei=Ito en-aut-mei=Sekiko kn-aut-name=ˆÉ“¡ÌŽq kn-aut-sei=ˆÉ“¡ kn-aut-mei=ÌŽq aut-affil-num=1 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=‰ª–{Šî kn-aut-sei=‰ª–{ kn-aut-mei=Šî aut-affil-num=2 ORCID= en-aut-name=MoriShuji en-aut-sei=Mori en-aut-mei=Shuji kn-aut-name=XGŽ¡ kn-aut-sei=X kn-aut-mei=GŽ¡ aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŒŸ¸‹Zp‰ÈŠwêU affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŒŸ¸‹Zp‰ÈŠwêU affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŒŸ¸‹Zp‰ÈŠwêU en-keyword=phosphacan (ƒzƒXƒtƒ@ƒJƒ“) kn-keyword=phosphacan (ƒzƒXƒtƒ@ƒJƒ“) en-keyword=core protein (ƒRƒA’`”’) kn-keyword=core protein (ƒRƒA’`”’) en-keyword=His-tagged proteins kn-keyword=His-tagged proteins en-keyword=recombinant protein (—Z‡’`”’) kn-keyword=recombinant protein (—Z‡’`”’) END start-ver=1.4 cd-journal=joma no-vol=9 cd-vols= no-issue=2 article-no= start-page=91 end-page=104 dt-received= dt-revised= dt-accepted= dt-pub-year=1999 dt-pub=19990226 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study on the correlation between the results of entrance examination and the academic record of the students in the department of laboratory technology kn-title=‰q¶‹ZpŠw‰È“üŠwŽÒ‚Ì‚Z•]“_,“üŠwŽŽŒ±¬Ñ‚Æ“üŠwŒã‚ÌŠw‹Æ¬Ñ‚ÌŠÖŒW \“üŠwŽÒ‘I”²,‹³ˆç•û–@‚̉ü‘P‚ÉŒü‚¯‚½Ž©ŒÈ“_ŒŸ¥•]‰¿(1)\ en-subtitle= kn-subtitle= en-abstract=The correlation between the school record in high school, result of entrance examination and the academic record, failure in promotion and withdrawal from school was examined in 361 students entered into department of laboratory technology from 1987 to 1995. 1) Thirty-nine students (10.8%) had failed in promotion, and 18 students (5%) had leaved from the school. The reason of withdrawal was refusal in 6 cases, and 4 students had changed their course to other universities. These cases were more frequent in the period until 1990 than in the period after 1991. 2) There were no differences in the school record in high school and the result of entrance examination among students who graduated scheduled period of attendance (regular students), those who failed in promotion, and those who had leaved the school. However, the students who failed in promotion had got higher score in entrance examination than regular students in 1987 and 1988. In contrast, regular students had got higher score in entrance examination than the students failed in promotion in 1991 and 1993. 3) The school record in high school could be cheked during the period from 1991 to1995. In this period, the students failed in promotion had got lower score in high school than regular students. Especially, the difference was significant in 1991 and 1993. 4) There was a significant positive correlation between the results in examination of general subjects and those in examination of technical and proffesional education. 5) The school records in high school had relatively weak positive correlation with the results of entrance examination. In contrast, both the school record in high school and result of entrance examination had clear positve correlations with both the results in examination of general subjects and technical and proffesional education. 6) However, the result of each subject of entrance examination, i.e. Japanese, Mathematics, English, and Science, had no or weak positive correlation with both the results in examination of general subjects and technical and proffesional education. 7) The students who had not passed the national examination of laboratory technologist had lower score in school record in high school, entrance examination, examination of general subjects and technical and proffesional education, but the diffenreces were not statistically significant. The results of the study indicate that there were students who failed in promotion or leaved school despite their excellent ability during four years following the establishment of School of Health Sciences, but thereafter the ability of students gradually became homogeneous and increased the students who failed in promotion because of insufficient ability. The highly positive correlation between the results in examination of general subjects and those in examination of technical and proffesional education indicate that the results of examination in the first year were directly reflected in the results of examination in second and third year, and that it is important to encourage the students's motivation and volition to study with ardor immediately after the entrance. The positive correlation of school record in high school and result of entrance examination with academic record after the entrance implicate the potential usefulness of school record in high school and result of entrance examination in determining the eligibility to enter the school. However, it is desirable to improve the subjects and problems of entrance examination because the result of each subject of entrance examination was poorly reflected in the academic record. kn-abstract=1987”N4ŒŽ‚©‚ç1995”N4ŒŽ‚Ì9”NŠÔ‚ɉq¶‹ZpŠw‰È‚Ö“üŠw‚µ‚½361–¼‚ð‘ÎÛ‚É,‚Z•]“_,“üŠwŽŽŒ±(Šw—ÍŽŽŒ±)¬Ñ‚Æ,“üŠwŒã‚ÌŠw‹Æ¬Ñ,‘ÞŠw,—¯”N,—Õ°ŒŸ¸‹ZŽt‘‰ÆŽŽŒ±‚Æ‚ÌŠÖŒW‚𒲂ׂ½¡ 1)“üŠwŽÒ‘”‚Í361–¼‚Å,‚±‚Ì‚¤‚¿—¯”NŽÒ‚ª39–¼(10,8%),‘ÞŠwŽÒ‚ª18–¼(5%)‚Å‚ ‚Á‚½¡‘ÞŠwŽÒ‚Ì’†‚É‚Í,ŽÀŽ¿“üŠwŽ«‘ÞŽÒ‚ª6–¼,4”N§‘åŠw‚Öi˜H‚ð•ÏX‚µ‚½ŽÒ‚ª4–¼‚¢‚½‚ª,‚±‚¤‚µ‚½‘ÞŠwŽÒ‚Í1992”N“x‚Ü‚Å‚Ì“üŠwŽÒ‚É‘½‚©‚Á‚½¡ 2)“üŠwŽÒ‘S‘Ì‚Å‚Í,—\’葲‹ÆŽÒ,—¯”NŽÒ,‘ÞŠwŽÒ‚ÌŠÔ‚Å‚Z•]“_,“üŠwŽŽŒ±¬Ñ‚É‚Í·‚ª‚È‚©‚Á‚½‚ª,“üŠw”N“x‚²‚Æ‚É‚Ý‚é‚Æ,1987,1988”N“x‚Í—¯”NŽÒ‚ª—\’葲‹ÆŽÒ‚É”ä‚ׂēüŠwŽŽŒ±‚Ì‘“¾“_‚ª‚‚¢ŒXŒü‚ª‚ ‚è,‹t‚É1991”N,1993”N“x‚Í—\’葲‹ÆŽÒ‚É”ä‚ׂėLˆÓ‚É’á‚©‚Á‚½¡ 3)‚Z•]“_‚Í,ƒf[ƒ^‚ª“üŽè‚Å‚«‚½1991”N“xˆÈ~ˆêŠÑ‚µ‚Ä—¯”NŽÒ‚Ì•]“_‚ª—\’葲‹ÆŽÒ‚æ‚è’á‚­, ‚Æ‚­‚É1991”N,1993”N“x‚Í—¯”NŽÒ‚Ì•]“_‚ª—LˆÓ‚É’á‚©‚Á‚½¡ 4)—¯”NŽÒ‚àŠÜ‚ß‚Ä,ˆê”Ê‹³ˆç‰È–ڂ̬тÆê–å‰È–ڂ̬тƂ̊ԂɗLˆÓ‚ð³‚Ì‘ŠŠÖ‚ª‚Ý‚ç‚ꂽ¡ 5)‚Z•]“_‚Æ“üŠwŽŽŒ±¬Ñ‚Æ‚ÌŠÔ‚É‚ÍŒy“x‚Ì‘ŠŠÖ‚µ‚©‚Ý‚ç‚ê‚È‚©‚Á‚½‚ª,‚Z•]“_‚¨‚æ‚Ñ“üŠwŽŽŒ±‘‡“_‚Í“üŠwŒã‚̈ê”Ê‹³ˆç‰È–Ú,ê–å‰È–ڂ̬тƂ‚¢³‚Ì‘ŠŠÖ‚ðŽ¦‚µ‚½¡ 6)‚µ‚©‚µ,ŒÂX‚Ì“üŠwŽŽŒ±‰È–Ú‚Ì“¾“_‚Í,“üŠwŒã‚̬тƑŠŠÖ‚µ‚È‚¢‚©,Œy“x‚Ì‘ŠŠÖ‚µ‚©‚Ý‚ç‚ê‚È‚©‚Á‚½¡ 7)‘‰ÆŽŽŒ±•s‡ŠiŽÒ‚Í,‚Z•]“_,“üŠwŽŽŒ±‘‡“_,ˆê”ʉȖڕ½‹Ï“_,ê–å‰È–Ú•½‹Ï“_‚Ì‚¢‚¸‚ê‚à‡ŠiŽÒ‚É”ä‚ׂē¾“_‚ª’á‚©‚Á‚½‚ª,—LˆÓ·‚Í‚È‚©‚Á‚½¡ˆÈã‚ÌŒ‹‰Ê‚©‚ç,’ZŠú‘åŠw•”ŠJÝ“–‰‚Í—¯”NŽÒ,‘ÞŠwŽÒ‚Ì’†‚É—\’葲‹ÆŽÒ‚æ‚èŠw—Í‚Ì‚ ‚éŠw¶‚ª‚¢‚½‚ª,”N‚ð’Ç‚¤‚²‚Æ‚É“üŠwŽÒ‚ÌŠw—Í‚ª‹ÏŽ¿‰»‚µ,Šw—Í‚ª•s\•ª‚È‚½‚ß‚É—¯”N‚·‚éŠw¶‚ª‘½‚­‚È‚Á‚Ä‚«‚Ä‚¢‚é‚ÆŒ¾‚¦‚éBˆê”Ê‹³ˆç‰È–ڂ̬тÆê–å‰È–ڂ̬тª‹­‚¢³‚Ì‘ŠŠÖ‚ðŽ¦‚·‚±‚Æ‚Í,1”NŽŸ‚̬тª‚»‚Ì‚Ü‚Ü2,3”NŽŸ‚̬тɔ½‰f‚³‚ê‚邱‚Æ‚ðŽ¦‚µ‚Ä‚¨‚è,“üŠw“–‰‚Ì“®‹@•t‚¯‚ƕ׊wˆÓ—~‚ÌŠ«‹N‚ªd—v‚È‚±‚Æ‚ðŽ¦‚µ‚Ä‚¢‚é¡‚Z•]“_‚âŠw—ÍŽŽŒ±‚̬т͓üŠwŒã‚̬тƂ悭‘ŠŠÖ‚µ‚Ä‚¨‚è,Šw¶‘I”²‚Ì—LŒø‚ÈŽw•W‚Å‚ ‚é‚Æl‚¦‚ç‚ꂽ‚ª,Še“üŽŽ‰È–Ú‚Æ‚Ì‘ŠŠÖ‚Í–R‚µ‚©‚Á‚½‚±‚Æ‚©‚ç,ŒÂX‚ÌŽŽŒ±‰È–Ú‚Ì–â‘è“à—e‚ɂ‚¢‚Ă͉ü‘P‚·‚ׂ«‰Û‘肪‚ ‚é‚ÆŽv‚í‚ꂽ¡ en-copyright= kn-copyright= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=‰ª–{Šî kn-aut-sei=‰ª–{ kn-aut-mei=Šî aut-affil-num=1 ORCID= en-aut-name=SakiyamaJunko en-aut-sei=Sakiyama en-aut-mei=Junko kn-aut-name=èŽR‡Žq kn-aut-sei=èŽR kn-aut-mei=‡Žq aut-affil-num=2 ORCID= en-aut-name=AkatsukaKazuya en-aut-sei=Akatsuka en-aut-mei=Kazuya kn-aut-name=Ԓ˘a–ç kn-aut-sei=Ô’Ë kn-aut-mei=˜a–ç aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŒŸ¸‹Zp‰ÈŠwêU affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŒŸ¸‹Zp‰ÈŠwêU affil-num=3 en-affil= kn-affil=•ŸŽR—Õ°ŒŸ¸ƒZƒ“ƒ^[ en-keyword=‚Z•]“_ (school record in high school) kn-keyword=‚Z•]“_ (school record in high school) en-keyword=“üŠwŽŽŒ±¬Ñ (result of entrance examination) kn-keyword=“üŠwŽŽŒ±¬Ñ (result of entrance examination) en-keyword=“üŠwŒã‚ÌŠw‹Æ¬Ñ (academic record) kn-keyword=“üŠwŒã‚ÌŠw‹Æ¬Ñ (academic record) en-keyword=—¯”N (failure in promotion) kn-keyword=—¯”N (failure in promotion) en-keyword=‘ÞŠw (withdrawal from school) kn-keyword=‘ÞŠw (withdrawal from school) END start-ver=1.4 cd-journal=joma no-vol=12 cd-vols= no-issue=1 article-no= start-page=63 end-page=70 dt-received= dt-revised= dt-accepted= dt-pub-year=2001 dt-pub=20011225 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Research on satisfaction of elderlies with dementia in health care facilities. kn-title=˜Vl•ÛŒ’Ž{Ý‚É‚¨‚¯‚é’s•ð˜Vl‚Ì–ž‘«“x’²¸ en-subtitle= kn-subtitle= en-abstract=The purpose of this study was to clarify if there is a relationship between the satisfaction of elderlies with dementia in health care facilities by subjective views of the investigator and their actions. The subjects of this investigation were 28 fully functional elderly clients with dementia who were living in 2 health care facilities. They or their family consented to take part in our research. 14 clients were chosen from each facilities. The investigators observed the clients for 48 hours and recorded where they were, with whom they were, what they did, as well as the client's level of satisfaction. The satisfaction levels were judged from the clients' appearances or attitudes by the investigations. There were five satisfaction including from 1 : unsatisfied to 5 : great satisfaction. The following three points were observed both in two facilities in common ; (1) the high satisfaction time period was "morning" when recreation was included. (2) the client received a high level of satisfaction when they were in the "recreation-room" or "outdoors", (3) the client received a high level of satisfaction whom they stayed with "their family" or "observers", when talking to someone or helping someone positively. Analysis of these results demonstrated there was similar pattern between the time of day and place and their companion or their actions among the subjects in two facilities. It can be assumed that it is able to observe elderlies with dementia satisfaction degree objectively. kn-abstract=2‚‚̘Vl•ÛŒ’Ž{Ý‚É“üŠ‚µ‚Ä‚¢‚é’s•ð˜Vl‚ɂ‚¢‚Ä,ŠÏŽ@ŽÒ‚É‚æ‚é”Þ‚ç‚Ì–ž‘«“x‚Æ‚»‚ÌŽž‚ÉŠÏŽ@‚³‚ꂽs“®‚ÌŠÖŒW‚𖾂炩‚É‚·‚邱‚Æ‚ð–Ú“I‚Æ‚·‚é¡’²¸‘ÎÛŽÒ‚Í,2‚‚̘Vl•ÛŒ’Ž{Ý‚É“üŠ’†‚Å,–{l‚Ü‚½‚͉Ƒ°‚æ‚è’²¸‚Ö‚Ì—¹Œn‚Ì“¾‚ç‚ꂽ,•às‰Â”\‚È’s•ð˜VlŠe14–¼,‡Œv28–¼‚Å‚ ‚é¡ŠÏŽ@ŽÒ‚Í‘ÎÛŽÒ‚Ìs“®‚ð48ŽžŠÔŠÏŽ@‚µ,‚Ç‚±‚Å’N‚Ɖ½‚ðs‚Á‚Ä‚¢‚é‚©‚Æ‚»‚ÌŽž‚Ì–ž‘«“x‚𒲸•[‚É‹L˜^‚µ‚½¡–ž‘«“x‚Í‘ÎÛŽÒ‚Ì•\î‚â‘Ô“x‚©‚çŠÏŽ@ŽÒ‚ª”»’f‚µ,‘å•Ï–ž‘«‚ð‡D‚Æ‚µ,‚Ç‚¿‚ç‚Æ‚àŒ¾‚¦‚È‚¢‚ð‡B,‘å•Ï•s–ž‘«‚ð‡@‚Æ‚µ‚½5’iŠK•]’è‚ÅŽ¦‚µ‚½¡‚»‚ÌŒ‹‰ÊˆÈ‰º‚Ì3“_‚ª–¾‚ç‚©‚Æ‚È‚Á‚½¡ 1)—¼Ž{Ý‚Å–ž‘«“x‚Ì‚‚¢ŽžŠÔ‘Ñ‚Í,ƒŒƒNƒŠƒG[ƒVƒ‡ƒ“‚ªŠÜ‚Ü‚ê‚é"Œß‘O’†‚ÌŽžŠÔ"‚Å‚ ‚Á‚½¡ 2)–ž‘«“x‚ª‚‚¢‚Ì‚Í,‹êŠ‚Å‚Í,"ƒŒƒNƒŠƒG[ƒVƒ‡ƒ“ƒ‹[ƒ€¥‰®ŠO"‚Å‚ ‚Á‚½¡ 3)“¯sŽÒ‚Í,"‰Æ‘°","ŠÏŽ@ŽÒ",s“®‚Í,"˜b‚ð‚·‚é",Žè“`‚¢‚ð‚·‚é‚È‚Ç"Ž©”­“I‚Èsˆ×"‚ª‘½‚­‚Ý‚ç‚ꂽ¡ˆÈã‚É‚æ‚è,2‚‚̎{Ý‚Å–ž‘«“x‚²‚Æ‚ÌŽžŠÔ‘Ñ,‹êŠ,“¯sŽÒ‚Æs“®‚ªŽ—’Ê‚Á‚Ä‚¢‚½‚±‚Æ‚©‚ç,‹qŠÏ“I‚É’s•ð˜Vl‚Ì–ž‘«“x‚ð”cˆ¬‚·‚邱‚Ƃ͉”\‚Å‚ ‚é‚Æl‚¦‚é¡ en-copyright= kn-copyright= en-aut-name=SumiyoshiKazuko en-aut-sei=Sumiyoshi en-aut-mei=Kazuko kn-aut-name=Z‹g˜aŽq kn-aut-sei=Z‹g kn-aut-mei=˜aŽq aut-affil-num=1 ORCID= en-aut-name=KawataChieko en-aut-sei=Kawata en-aut-mei=Chieko kn-aut-name=ì“c’qŒbŽq kn-aut-sei=ì“c kn-aut-mei=’qŒbŽq aut-affil-num=2 ORCID= en-aut-name=OkanoHatsue en-aut-sei=Okano en-aut-mei=Hatsue kn-aut-name=‰ª–쉎} kn-aut-sei=‰ª–ì kn-aut-mei=‰Ž} aut-affil-num=3 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=‰ª–{Šî kn-aut-sei=‰ª–{ kn-aut-mei=Šî aut-affil-num=4 ORCID= en-aut-name=TakahashiKiyoshi en-aut-sei=Takahashi en-aut-mei=Kiyoshi kn-aut-name=‚‹´¹”V kn-aut-sei=‚‹´ kn-aut-mei=¹”V aut-affil-num=5 ORCID= en-aut-name=MoriShuji en-aut-sei=Mori en-aut-mei=Shuji kn-aut-name=XGŽ¡ kn-aut-sei=X kn-aut-mei=GŽ¡ aut-affil-num=6 ORCID= en-aut-name=TsujimotoHisae en-aut-sei=Tsujimoto en-aut-mei=Hisae kn-aut-name=’Ò–{‹v] kn-aut-sei=’Ò–{ kn-aut-mei=‹v] aut-affil-num=7 ORCID= en-aut-name=SueEiko en-aut-sei=Sue en-aut-mei=Eiko kn-aut-name={]‰pŽq kn-aut-sei={] kn-aut-mei=‰pŽq aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰È affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰È affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰È affil-num=7 en-affil= kn-affil=˜Vl•ÛŒ’Ž{Ý”’”~‚Ì‹u affil-num=8 en-affil= kn-affil=‰îŒì˜Vl•ÛŒ’Ž{݃Tƒ“ƒXƒNƒGƒAÀ“ì en-keyword=˜Vl•ÛŒ’Ž{Ý (old people's health facilities) kn-keyword=˜Vl•ÛŒ’Ž{Ý (old people's health facilities) en-keyword=’s•ð˜Vl (elderlies with dementia) kn-keyword=’s•ð˜Vl (elderlies with dementia) en-keyword=–ž‘«“x (satisfaction) kn-keyword=–ž‘«“x (satisfaction) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=9 end-page=14 dt-received= dt-revised= dt-accepted= dt-pub-year=2004 dt-pub=20041215 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of Coicis semen and Rhizopus oligosporus-fermented Coicis semen (tempeh) on serum cholesterol in the rat kn-title=‚Í‚Æ‚Þ‚¬,‚Í‚Æ‚Þ‚¬ƒeƒ“ƒy‚̃‰ƒbƒgƒRƒŒƒXƒeƒ[ƒ‹‘ãŽÓ‰ü‘Pì—p‚ÉŠÖ‚·‚錤‹† en-subtitle= kn-subtitle= en-abstract=The effect of Coicis semen and Rhizopus oligosporus-fermented Coicis semen (tempeh) on serum cholesterol fractions was examined in the rat. Twelve-week-old male Sprague-Dawley rats were received commercial MF meal (control group), Coicis semen-containing MF meal (Coicis semen group), or tempeh-containing MF meal (tempeh group). Cholesterol fractions were analyzed by high performance liquid chromatography at the start of experiment, and 2, 6, 18 weeks later. No difference was found in body weight nor total cholesterol among the three groups. LDL cholesterol was significantly lowered in the tempeh group at 2, 6, 18 weeks. LDL cholesterol/HDL cholesterol ratio also decreased at 2 and 18 weeks. In the both Coicis semen- and tempeh-fooded groups, LDL cholesterol and LDL cholesterol/HDL cholesterol ratio were lower than the control group although they were not statistically significant. No difference was found in HDL cholesterol among the three groups. The results suggest that tempeh may have a favorable effect on cholesterol metabolism. kn-abstract=‚Í‚Æ‚Þ‚¬(Coicis semen)‚ðƒeƒ“ƒy‹Û(Rhizopus oligosporus)‚Å”­y‚µ‚½‚Í‚Æ‚Þ‚¬ƒeƒ“ƒy(ƒeƒ“ƒy)‚ÌŒŒ´ƒRƒŒƒXƒeƒ[ƒ‹‘ãŽÓ‚ɑ΂·‚éì—p‚ðŒŸ“¢‚µ‚½¡¶Œã12T—î‚ÌSprague-DawleyŒn—Yƒ‰ƒbƒg‚ÉŽs”̌Ō`Ž”—¿(ƒRƒ“ƒgƒ[ƒ‹ŒQ),‚Í‚Æ‚Þ‚¬¬‡Ž”—¿(‚Í‚Æ‚Þ‚¬ŒQ),ƒeƒ“ƒy¬‡Ž”—¿(ƒeƒ“ƒyŒQ)‚ð“Š—^‚µ,2,6,18TŠÔŒã‚É‚‘¬‰t‘̃Nƒƒ}ƒgƒOƒ‰ƒtƒB[–@‚ÅŒŒ´ƒRƒŒƒXƒeƒ[ƒ‹‚𑪒肵‚½¡‘Ìd‘‰Á,‘ƒRƒŒƒXƒeƒ[ƒ‹‚Í‚¢‚¸‚ê‚ÌŽž“_‚Å‚à3ŒQŠÔ‚É·‚ª‚È‚©‚Á‚½‚ª,ƒeƒ“ƒyŒQ‚Å‚Í“Š—^‘O‚Æ”äŠr‚µ‚Ä2,6,18TŠÔŒã‚ÉLDLƒRƒŒƒXƒeƒ[ƒ‹‚ª—LˆÓ‚ɒቺ‚µ,LDLƒRƒŒƒXƒeƒ[ƒ‹/HDLƒRƒŒƒXƒeƒ[ƒ‹”ä‚à2,18TŠÔŒã‚É—LˆÓ‚ɒቺ‚µ‚½¡ƒeƒ“ƒyŒQ‚̓Rƒ“ƒgƒ[ƒ‹ŒQ‚Æ”äŠr‚µ‚Ä‚àLDLƒRƒŒƒXƒeƒ[ƒ‹‚ÆLDLƒRƒŒƒXƒeƒ[ƒ‹/HDLƒRƒŒƒXƒeƒ[ƒ‹”䂪’á‚­,‚Í‚Æ‚Þ‚¬ŒQ‚Å‚à’á‚¢ŒXŒü‚ª‚Ý‚ç‚ꂽ‚ª,—LˆÓ·‚Í‚È‚©‚Á‚½¡ˆÈã‚©‚ç,ƒeƒ“ƒy‚ªƒRƒŒƒXƒeƒ[ƒ‹‘ãŽÓ‰ü‘Pì—p‚ð‚à‚‚±‚Æ‚ªŽ¦´‚³‚ꂽ¡ en-copyright= kn-copyright= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=‰ª–{Šî kn-aut-sei=‰ª–{ kn-aut-mei=Šî aut-affil-num=1 ORCID= en-aut-name=UsuiShinichi en-aut-sei=Usui en-aut-mei=Shinichi kn-aut-name=‰Pˆä^ˆê kn-aut-sei=‰Pˆä kn-aut-mei=^ˆê aut-affil-num=2 ORCID= en-aut-name=OkazakiMitsuyo en-aut-sei=Okazaki en-aut-mei=Mitsuyo kn-aut-name=‰ªèŽO‘ã kn-aut-sei=‰ªè kn-aut-mei=ŽO‘ã aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŒŸ¸‹Zp‰ÈŠwêU affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŒŸ¸‹Zp‰ÈŠwêU affil-num=3 en-affil= kn-affil=“Œ‹žˆã‰ÈŽ•‰È‘åŠw‹³—{•” en-keyword=‚Í‚Æ‚Þ‚¬ (Coicis semen) kn-keyword=‚Í‚Æ‚Þ‚¬ (Coicis semen) en-keyword=‚Í‚Æ‚Þ‚¬ƒeƒ“ƒy (Rhizopus oligosporus, tempeh) kn-keyword=‚Í‚Æ‚Þ‚¬ƒeƒ“ƒy (Rhizopus oligosporus, tempeh) en-keyword=ƒRƒŒƒXƒeƒ[ƒ‹ (cholesterol) kn-keyword=ƒRƒŒƒXƒeƒ[ƒ‹ (cholesterol) en-keyword=ƒ‰ƒbƒg (rat) kn-keyword=ƒ‰ƒbƒg (rat) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=2 article-no= start-page=63 end-page=69 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Investigation of the tracheal suctioning-related microbialcolonization in home care patients with tracheotomy kn-title=‹CŠÇ“à‹zˆø‚ð•K—v‚Æ‚·‚éÝ‘î—×{Š³ŽÒ‚ÌŠ´õŠÇ—‚ÌŽÀ‘Ô en-subtitle= kn-subtitle= en-abstract=Microbial colonization related to tracheal toilet was investigated in three home care patients who had tracheotomy with or without mechanical ventilation. We focused on the manipulation of suctioning tube to develop a effective and low-cost guidline for infection control. Tracheal suctioning was doned by wife in all the patients. Catheters used for suctioning was generally wiped with alcohol, washed in deionized or boiled water, and stored in alcohol-wiped container or immersed in 0.05% gluconate chlorhexizine. Catheter was changed into new one every 1.5 to 7 days. Samples were obtained from catheter, water used for washing, container as well as patients and their caregivers, and cultured on agar culture plate for Staphylococcus aureus, or Escherichia coli. Colonization of gauze around tracheotomy and water used for washing was detected in two patinets. E. coli and S. aureus were common organism colonizing gauze around tracheotomy. Therefore, it was suggested that the manipulation of the tracheal suctioning in home care influence on microbial colonization. kn-abstract=‹CŠÇ“à‹zˆø‚ð•K—v‚Æ‚·‚éÝ‘î—×{Š³ŽÒ‚ɑ΂µ,ˆÀ‘S‚ÅŒoÏ“I‚ÈŠ´õŠÇ—•û–@‚ðŒŸ“¢‚·‚邽‚ß,Ý‘îƒPƒA‚É‚¨‚¯‚é‹CŠÇ“à‹zˆø‚ÌŽÀ‘Ô‚Æ,‹zˆøŠÖ˜A•¨•i‚Ì׋ۊw“I’²¸‚ðŽÀŽ{‚µ‚½B‘ÎÛ‚Í‹CŠÇØŠJ‚ª‚³‚ê,ˆã—Èˑ¶“x‚Ì‚‚¢Š³ŽÒ3–¼‚Å‚ ‚è,‹CŠÇ“à‹zˆø‚Í‘S‚ÄŠ³ŽÒ‚ÌÈ‚ªs‚Á‚Ä‚¢‚½B‹zˆøŒã‚̃Jƒe[ƒeƒ‹‚ÍŠO‘¤‚ðƒAƒ‹ƒR[ƒ‹–È‚Å´@‚µ,“ào‚ðôò…‚Åôò‚µ‚Ä‚¢‚½BƒJƒe[ƒeƒ‹‚Í,0.05%ƒOƒ‹ƒRƒ“Ž_ƒNƒƒ‹ƒwƒLƒVƒWƒ“‚ÉZ’Ђ ‚é‚¢‚Í,´Œ‰‚ÈŠ£‘‡—eŠí‚É•ÛŠÇ‚³‚ê‚Ä‚¢‚½BƒJƒe[ƒeƒ‹‚ÌŒðŠ·ŽžŠú‚Í,1.5“ú‚©‚ç7“ú‚Ƃ΂ç‚‚«‚ª‚ ‚Á‚½BƒJƒe[ƒeƒ‹,ôò…,Z’׉t“™‚ÌŽŽ—¿‚ð,ˆê”Ê׋Û,‰©FƒuƒhƒE‹…‹Û,‘å’°‹ÛŒQ‚ÌŠ¦“V”|’n‚Å”|—{‚µ‚½‚Æ‚±‚ë,ŠeŽŽ—¿‚©‚çˆê”Ê׋Û,‰©FƒuƒhƒE‹…‹Û,‘å’°‹ÛŒQ‚ªŒŸo‚³‚ꂽ‚ª,ƒJƒe[ƒeƒ‹‚Ì•ÛŠÇ•û–@‚̈Ⴂ‚É‚æ‚é׋ۉ˜õ‚É·‚Í”F‚ß‚ç‚ê‚È‚©‚Á‚½¡‚Ü‚½,‹CŠÇØŠJ•”ƒK[ƒ[‚©‚ç‚Í,ˆê”Ê׋Û,‰©FƒuƒhƒE‹…‹Û,‘å’°‹ÛŒQ‚ªŒŸo‚³‚ꂽ¡‚±‚ê‚ç‚æ‚è,‹CŠÇ“à‹zˆøƒJƒe[ƒeƒ‹‚¨‚æ‚Ñ,ôò…‚âZa—pÁ“ʼnt‚Ì´Œ‰ŠÇ—‚Ì•K—v«‚ªŽ¦´‚³‚ꂽ¡ en-copyright= kn-copyright= en-aut-name=WatanabeKumi en-aut-sei=Watanabe en-aut-mei=Kumi kn-aut-name=“n糋v”ü kn-aut-sei=“nç³ kn-aut-mei=‹v”ü aut-affil-num=1 ORCID= en-aut-name=KanzakiHitomi en-aut-sei=Kanzaki en-aut-mei=Hitomi kn-aut-name=›èm”ü kn-aut-sei=›è kn-aut-mei=m”ü aut-affil-num=2 ORCID= en-aut-name=SendaYoshiko en-aut-sei=Senda en-aut-mei=Yoshiko kn-aut-name=ç“cDŽq kn-aut-sei=ç“c kn-aut-mei=DŽq aut-affil-num=3 ORCID= en-aut-name=OkamotoMotoi en-aut-sei=Okamoto en-aut-mei=Motoi kn-aut-name=‰ª–{Šî kn-aut-sei=‰ª–{ kn-aut-mei=Šî aut-affil-num=4 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŠÅŒìŠwêU affil-num=2 en-affil= kn-affil=‰ªŽR–K–âŠÅŒìƒXƒe[ƒVƒ‡ƒ“ŠÅŒì‹¦‰ï affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŠÅŒìŠwêU affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•ÛŒ’Šw‰ÈŒŸ¸‹Zp‰ÈŠwêU en-keyword=Š´õŠÇ— (Infection control) kn-keyword=Š´õŠÇ— (Infection control) en-keyword=‹CŠÇ“à‹zˆø (tracheal suctioning) kn-keyword=‹CŠÇ“à‹zˆø (tracheal suctioning) en-keyword=Ý‘îƒPƒA (home care) kn-keyword=Ý‘îƒPƒA (home care) en-keyword=‰îŒìŽÒ (caregiver) kn-keyword=‰îŒìŽÒ (caregiver) END start-ver=1.4 cd-journal=joma no-vol=15 cd-vols= no-issue=1 article-no= start-page=33 end-page=65 dt-received= dt-revised= dt-accepted= dt-pub-year=2009 dt-pub=20090331 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Morphology and Anatomy of Holocene Raised Coral Reef Terraces in Kodakara Island, Tokara Islands, northwestern Pacific, Japan kn-title=“fŠ…šh—ñ“‡E¬•ó“‡‚ÌŠ®V¢—²‹NƒTƒ“ƒSÊ’i‹u’nŒ`‚Æ‘ÍÏ\‘¢ en-subtitle= kn-subtitle= en-abstract= kn-abstract=Well-developed Holocene raised coral reef terraces are formed in Kodakara Island (29‹13'N 129‹19'E), Tokara Islands, northwestern Pacific, Japan. Detailed morphology and sedimentary structure of the raised reef terraces are observed by field survey through the terraces surface and core drillings. The Holocene raised reef in Kodakara Island are divided into three terraces (TI to III). The surface geo-biological facies and paleo-morphology such as spur and groove system or reef mounds are well preserved on these terraces. The raised coral reefs in Kodakara Island consist of reef flats and reef slopes. No lagoon formed in these terraces. On the raised reef surface, we observed five distinct reefal facies (S-f1-5). The platy and encrusting Acropora facies is the major constituent of the terrace surfaces. We obtained seven drilling cores (B1 to 7) from Terraces I and II along a transect in the southern part of the island. The thickness of the Holocene reef is more than 14m which is approximately equivalent to the Holocene reefs in the middle and southern Ryukyu Islands. Sedimentary structure consists of seven facies (C-f1-7: five reefal and two non-reefal facies). The drilling cores indicating the shallowing sequence at the upward of the cores which characterized by platy-encrusting Acropora facies overlying massive Porites, favid and/or encrusting-foliaceous coral facies. It may indicate the environmental change such as wave-energy gradients and turbidity during the reef development. en-copyright= kn-copyright= en-aut-name=HamanakaNozomu en-aut-sei=Hamanaka en-aut-mei=Nozomu kn-aut-name=à_’†–] kn-aut-sei=à_’† kn-aut-mei=–] aut-affil-num=1 ORCID= en-aut-name=KanHironobu en-aut-sei=Kan en-aut-mei=Hironobu kn-aut-name=›_L kn-aut-sei=› kn-aut-mei=_L aut-affil-num=2 ORCID= en-aut-name=NakashimaYosuke en-aut-sei=Nakashima en-aut-mei=Yosuke kn-aut-name=’†“‡—m“T kn-aut-sei=’†“‡ kn-aut-mei=—m“T aut-affil-num=3 ORCID= en-aut-name=HoriNobuyuki en-aut-sei=Hori en-aut-mei=Nobuyuki kn-aut-name=–xMs kn-aut-sei=–x kn-aut-mei=Ms aut-affil-num=4 ORCID= en-aut-name=OkamotoTakehiro en-aut-sei=Okamoto en-aut-mei=Takehiro kn-aut-name=‰ª–{Œ’—T kn-aut-sei=‰ª–{ kn-aut-mei=Œ’—T aut-affil-num=5 ORCID= en-aut-name=OhashiTomoya en-aut-sei=Ohashi en-aut-mei=Tomoya kn-aut-name=‘å‹´—Ï–ç kn-aut-sei=‘å‹´ kn-aut-mei=—Ï–ç aut-affil-num=6 ORCID= en-aut-name=AdachiHiroshi en-aut-sei=Adachi en-aut-mei=Hiroshi kn-aut-name=ˆÀ’BŠ° kn-aut-sei=ˆÀ’B kn-aut-mei=Š° aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠw affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠw affil-num=3 en-affil= kn-affil=—L–¾H‹Æ‚“™ê–åŠwZ affil-num=4 en-affil= kn-affil=“Þ—Ç‘åŠw affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠw affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠw affil-num=7 en-affil= kn-affil=(Š”)ƒWƒIƒAƒNƒg en-keyword=Holocene kn-keyword=Holocene en-keyword=coral reef terrace kn-keyword=coral reef terrace en-keyword=drilling kn-keyword=drilling en-keyword=sedimentary structure kn-keyword=sedimentary structure en-keyword=Tokara Islands kn-keyword=Tokara Islands en-keyword=northwestern Pacific kn-keyword=northwestern Pacific END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=107 end-page=114 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Three cases of rheumatoid arthritis with biliary tract cancer kn-title=–«ŠÖ߃ŠƒEƒ}ƒ`‚É’_“¹Œnˆ««Žîá‡‚ð‡•¹‚µ‚½3—á en-subtitle= kn-subtitle= en-abstract=The relationships between rheumatoid arthritis and malignant disease have been a focus of controversy for many years. Many studies of patients with rheumatoid arthritis have found no increases in overall cancer rates. Although significant elevations in rates of lymphoma, myeloma and malignant disease in patients treated with immunosuppressive drugs have been reported, it has been considered that gastrointestinal and biliary tract cancer in patients with rheumatoid arthritis is rare. We recently experienced three cases of rheumatoid arthritis with biliary tract cancer. They were gall bladder, cancer, bile duct cancer and cancer of papilla of Vater. Patients with rheumatoid arthritis should be carefully monitored for malignant disease. kn-abstract=ˆê”Ê“I‚É,–«ŠÖ߃ŠƒEƒ}ƒ`‚ɂ͈««Žîᇂ̇•¹‚Í­‚È‚¢‚ÆŒ¾‚í‚ê‚Ä‚¢‚é¡“Á‚É,Á‰»ŠíŒn‚ ‚é‚¢‚Í’_“¹Œnˆ««Žîá‡‚ð‡•¹‚µ‚½‚Æ‚¢‚¤•ñ‚Í‹É‚ß‚Ä­‚È‚¢¡‰äX‚Í–«ŠÖ߃ŠƒEƒ}ƒ`‚ÌŒo‰ß’†,’_“¹Œnˆ««Žîá‡‚ð‡•¹‚µ‚½3—á‚ðŒoŒ±‚µ‚½¡3Ç—á‚Í‚»‚ꂼ‚ê’_”XŠà,ŠÌ“à’_ŠÇŠà,“û“ª•”Šà‚ð‡•¹‚µ‚Ä‚¢‚½¡”ñí‚É‹H‚ÈÇ—á‚Å‚ ‚è,•¶Œ£“IlˆÄ‚ðŠÜ‚ß•ñ‚·‚é¡ en-copyright= kn-copyright= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=ŠâŠ_®Žj kn-aut-sei=ŠâŠ_ kn-aut-mei=®Žj aut-affil-num=1 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=’Ñ–ì_Žj kn-aut-sei=’Ñ–ì kn-aut-mei=_Žj aut-affil-num=2 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=Œäät®Žu kn-aut-sei=Œäät kn-aut-mei=®Žu aut-affil-num=3 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=Œõ‰„•¶—T kn-aut-sei=Œõ‰„ kn-aut-mei=•¶—T aut-affil-num=4 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=•Ûè‘×O kn-aut-sei=•Ûè kn-aut-mei=‘×O aut-affil-num=5 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=ˆ°“ckŽO kn-aut-sei=ˆ°“c kn-aut-mei=kŽO aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=‰ª–{½ kn-aut-sei=‰ª–{ kn-aut-mei=½ aut-affil-num=7 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=’J蟘N kn-aut-sei=’Jè kn-aut-mei=Ÿ˜N aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=8 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È en-keyword=–«ŠÖ߃ŠƒEƒ}ƒ` (rheumatoid arthritis) kn-keyword=–«ŠÖ߃ŠƒEƒ}ƒ` (rheumatoid arthritis) en-keyword=’_“¹Œnˆ««Žîᇠ(biliary tract cancer) kn-keyword=’_“¹Œnˆ««Žîᇠ(biliary tract cancer) en-keyword=’_”XŠà (gall bladder cancer) kn-keyword=’_”XŠà (gall bladder cancer) en-keyword=’_ŠÇŠà (bile duct cancer) kn-keyword=’_ŠÇŠà (bile duct cancer) en-keyword=“û“ª•”Šà (cancer of papilla of Vater) kn-keyword=“û“ª•”Šà (cancer of papilla of Vater) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=99 end-page=106 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Diet therapy with ƒ¿-linolenic acid-enriched perilla seed oil on pulmonary emphysema. kn-title=n-3ŒnŽ‰–bŽ_‚ð‹­‰»‚µ‚½HŽ–—Ö@‚ª—LŒø‚Æl‚¦‚ç‚ꂽ”x‹CŽî‚̈ê—á en-subtitle= kn-subtitle= en-abstract=An effective treatment of advanced stages of chronic obstructive pulmonary disease (COPD) has not been estadlished yet. We report out recent experience of one patient with pulmonary emphysema treated with dietary supplementation with n-3 fatty acid for two months. He presented improvements in clinical symptoms and pulmonary function, and suppression in generation of leukotriene B(4) (LTB(4) )by peripheral leukocytes. Weconsequently suppose that dietary treatment with n-3 fatty acids (perilla seed oil) may be beneficial for the treatment of pulmonary emphysema by inhibiting the conversion of arachidonic acid (AA) to leukotrienes (LTs) and prostanoids competitively. kn-abstract=Ç—á‚Í67Î,’j«¡Žå‘i‚͘J쎞ŒÄ‹z¢“ï¡y‘æˆê‰ñ–Ú“ü‰@z•½¬7”N9ŒŽ‚©‚ç12ŒŽ‚Ü‚Å“ü‰@‚µ,–ò•¨—Ö@,•¡‡‰·ò—Ö@‚ðs‚È‚Á‚½¡Ž©ŠoÇó‚Í‚â‚â‰ü‘P‚ª‚Ý‚ç‚ꂽ‚ª,ŒÄ‹z‹@”\ŒŸ¸ŠŒ©‚̉ü‘P‚Í“¾‚ç‚ê‚È‚©‚Á‚½¡y‘æ“ñ‰ñ–Ú“ü‰@z•½¬8”N8ŒŽ‚©‚ç12ŒŽ‚Ü‚Å“ü‰@¡n-3ŒnŽ‰–bŽ_‹­‰»HŽ–—Ö@‚à•¹—p‚µ‚½¡Ž©ŠoÇ󂨂æ‚Ñ,ŒÄ‹z‹@”\ŒŸ¸ã,FVC,FEV(1.0),PEF‚Ȃǂɉü‘P‚ð”F‚ß‚½¡n-3ŒnŽ‰–bŽ_‚̓Aƒ‰ƒLƒhƒ“Ž_‘ãŽÓ‚ð’Ê‚µ‚ăƒCƒRƒgƒŠƒGƒ“‡¬‚ÉŠÖ—^‚·‚é‚Æ„’肳‚ê‚邪,Œo‰ß’†‚É”’ŒŒ‹…‚ÌLTB(4)ŽY¶”\‚ÌŒ¸­‚ð”F‚ß‚½B‚±‚ÌÇ—á‚Í”x‹CŽî‚ɑ΂·‚én-3ŒnŽ‰–bŽ_‹­‰»HŽ–—Ö@‚Ì—L—p«‚ªŽ¦´‚³‚ê,•a‘Ô‚ðl‚¦‚éã‚Å‚à‹»–¡[‚¢‚Æl‚¦‚ç‚ꂽ‚Ì‚Å•ñ‚·‚éB en-copyright= kn-copyright= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=’Ñ–ì_Žj kn-aut-sei=’Ñ–ì kn-aut-mei=_Žj aut-affil-num=1 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=ˆ°“ckŽO kn-aut-sei=ˆ°“c kn-aut-mei=kŽO aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=Œõ‰„•¶—T kn-aut-sei=Œõ‰„ kn-aut-mei=•¶—T aut-affil-num=3 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=Œäät®Žu kn-aut-sei=Œäät kn-aut-mei=®Žu aut-affil-num=4 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=‰ª–{½ kn-aut-sei=‰ª–{ kn-aut-mei=½ aut-affil-num=5 ORCID= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=ŠâŠ_®Žj kn-aut-sei=ŠâŠ_ kn-aut-mei=®Žj aut-affil-num=6 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=•Ûè‘×O kn-aut-sei=•Ûè kn-aut-mei=‘×O aut-affil-num=7 ORCID= en-aut-name=TsujiTakao en-aut-sei=Tsuji en-aut-mei=Takao kn-aut-name=’ÒF•v kn-aut-sei=’Ò kn-aut-mei=F•v aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=’J蟘N kn-aut-sei=’Jè kn-aut-mei=Ÿ˜N aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=8 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æˆê“à‰È affil-num=9 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È en-keyword=”x‹CŽî (pulmonary emphysema) kn-keyword=”x‹CŽî (pulmonary emphysema) en-keyword=n-3ŒnŽ‰–bŽ_ (n-3 fatty acid) kn-keyword=n-3ŒnŽ‰–bŽ_ (n-3 fatty acid) en-keyword=HŽ–—Ö@ (diet therapy) kn-keyword=HŽ–—Ö@ (diet therapy) en-keyword=ƒƒCƒRƒgƒŠƒGƒ“‡¬ (leukotriene) kn-keyword=ƒƒCƒRƒgƒŠƒGƒ“‡¬ (leukotriene) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=80 end-page=93 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ŒÄ‹zŠíŽ¾Š³‚̃ŠƒnƒrƒŠƒe[ƒVƒ‡ƒ“.‹CŠÇŽxšb‘§‚Ì•a‘Ô“I“Á’¥‚ÆŠÖ˜A‚µ‚½‰·ò—Ö@‚ÌŒø‰Ê kn-title=Rehabilitation for patients with respiratory disease. Spa efficacy in relation to pathophysiological characteristics of bronchial asthma. en-subtitle= kn-subtitle= en-abstract=‹ß”N˜V”NŽÒ‚̌ċzŠíŽ¾Š³‚ª‘‰Á‚µ‚‚‚ ‚願V”NŽÒ‚̌ċzŠíŽ¾Š³‚Ì•a‘Ô“I“Á’¥‚ÍŽá”NŽÒ‚Ì‚»‚ê‚Æ‚Í–¾‚ç‚©‚ɈقȂÁ‚Ä‚¢‚é¡–{˜_•¶‚Å‚Í,˜V”NŽÒ‚̌ċzŠíŽ¾Š³,‚È‚©‚Å‚à‹CŠÇŽxšb‘§‚ɑ΂·‚鉷ò—Ö@‚ð’†S‚Æ‚µ‚½ƒŠ-ƒrƒŠƒe-ƒVƒ‡ƒ“‚ɂ‚¢‚Ä,‚»‚Ì•a‘Ô“I“Á’¥‚ÆŠÖ˜A‚µ‚Ď኱‚Ì’mŒ©‚ðq‚ׂ顕¡‡‰·ò—Ö@‚Í2‚‚Ìì—p,‚·‚È‚í‚¿’¼Úì—p‚ÆŠÔÚì—p‚ð—L‚µ‚Ä‚¢‚é¡Š³ŽÒ‚ÌŽ©,‘¼ŠoÇó‚Í1-2ƒJŒŽ‚̉·ò—Ö@‚É‚æ‚è–¾‚ç‚©‚ɉü‘PŒXŒü‚ðŽ¦‚·‚ª,“¯Žž‚É,Š·‹C‹@”\‚̉ü‘P,‹C“¹‰ß•q«‚â‹C“¹’ïR‚̒ቺ‚ªŠÏŽ@‚³‚ê‚é¡‚±‚ê‚ç‚̉·ò—Ö@‚Ì’¼Úì—p‚Ì‚Í‚©,ŒÄ‹z‹Ø‚Ì‘‹­,Ž©—¥_ŒoŒn‚̈À’艻,¸_“IƒŠƒ‰ƒbƒNƒX,’ቺ‚µ‚½•›t”玿‹@”\‚̉ü‘P,‚È‚Ç‚ÌŠÔÚì—p‚àŠÏŽ@‚³‚ê‚é¡‹C“¹‚Ì•a‘Ô¶—“I“Á’¥‚æ‚蕪—Þ‚µ‚½šb‘§‚Ì—Õ°•aŒ^‚ÉŠÖ‚µ‚Ä‚Í,‰ß•ª”å‚â׋CŠÇŽx•Âǂ𔺂¤‚悤‚È•a Œ^‚ɑ΂µ‚Ä,‰·ò—Ö@‚Í—LŒø«‚ª‚‚¢¡‚±‚ê‚ç‚ÌŒ‹‰Ê‚Í,•¡‡‰·ò—Ö@‚ªŒÄ‹zŠíŽ¾Š³‚ÌŽ¡—ÂȂ¢‚µƒŠƒnƒrƒŠƒe[ƒVƒ‡ƒ“‚Æ‚µ‚Ä—L—p‚Å‚ ‚邱‚Æ‚ðŽ¦‚µ‚Ä‚¢‚é¡ kn-abstract=The number of patients with respiratory disease in the elderly has been increasing in recent years. Pathophysiological characteristic of respiratory diseases in older patients is clearly different from that in younger patients. In this study, rehabilitation for patients with respiratory disease, particularly bronchial asthma, in the elderly was discussed in relation to pathophysiology of asthma. Complex spa therapy has two kinds of actions, direct and indirect actions. Subjective and objective symptoms of patients with asthma are improved by spa therapy for 1-2 months, accompanied with improvement of ventilatory function, and decrease in bronchial hyperresponsiveness and respiratory resistance. In addition to these direct action of spa therapy, increase in strength of respiratory muscle, stability of autonomic nerve syetem, psychical relaxation, and inprovement of suppressed function of adrenocortical glands are observed as indirect action of spa therapy. Regarding clinical asthma type classified by pathophysiological changes of the airways, spa therapy was more effective in patients with hypersecretion and bronchiolar obstruction. These results suggest that complex spa therapy is available as rehabilitation and/or treatment for patients with respiratory disease. en-copyright= kn-copyright= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=’J蟘N kn-aut-sei=’Jè kn-aut-mei=Ÿ˜N aut-affil-num=1 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=Œäät®Žu kn-aut-sei=Œäät kn-aut-mei=®Žu aut-affil-num=2 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=Œõ‰„•¶—T kn-aut-sei=Œõ‰„ kn-aut-mei=•¶—T aut-affil-num=3 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=•Ûè‘×O kn-aut-sei=•Ûè kn-aut-mei=‘×O aut-affil-num=4 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=ˆ°“ckŽO kn-aut-sei=ˆ°“c kn-aut-mei=kŽO aut-affil-num=5 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=’Ñ–ì_Žj kn-aut-sei=’Ñ–ì kn-aut-mei=_Žj aut-affil-num=6 ORCID= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=‰ª–{½ kn-aut-sei=‰ª–{ kn-aut-mei=½ aut-affil-num=7 ORCID= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=ŠâŠ_®Žu kn-aut-sei=ŠâŠ_ kn-aut-mei=®Žu aut-affil-num=8 ORCID= en-aut-name=YamamotoKazuhiko en-aut-sei=Yamamoto en-aut-mei=Kazuhiko kn-aut-name=ŽR–{˜a•F kn-aut-sei=ŽR–{ kn-aut-mei=˜a•F aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=8 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=9 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È en-keyword=‹CŠÇŽxšb‘§ (Bronchial asthma) kn-keyword=‹CŠÇŽxšb‘§ (Bronchial asthma) en-keyword=ƒŠƒnƒrƒŠƒe[ƒVƒ‡ƒ“ (rehabilitation) kn-keyword=ƒŠƒnƒrƒŠƒe[ƒVƒ‡ƒ“ (rehabilitation) en-keyword=•¡‡‰·ò—Ö@ (complex spa therapy) kn-keyword=•¡‡‰·ò—Ö@ (complex spa therapy) en-keyword=Š·‹C‹@”\ (ventilatory function) kn-keyword=Š·‹C‹@”\ (ventilatory function) en-keyword=•›t”玿 (adrenocortical glands) kn-keyword=•›t”玿 (adrenocortical glands) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=51 end-page=58 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical effect of spa therapy on lumbargo kn-title=˜’Éǂɑ΂·‚鉷ò—Ö@‚ÌŒø‰Ê en-subtitle= kn-subtitle= en-abstract=Clinical effect of spa therapy was evaluated in 12 patients with lumbargo by a scoring system based on the standard judgement of therapy for lumbargo by Japanese Society of Orthopedics. The score for each category of subjective symptoms, objective symptoms, daily life activity, and disorder of urinary bladder, and total score calculated from each score were compared before and after spa therapy. A significant improvement of subjective symptoms, daily life activity, and total score was observed after spa therapy. However objective symptom was not significantly improved. The effects of spa therapy was larger in patients under age of 65, and in those who had long-term spa therapy more than 80 days during their admission. The results suggest that spa therapy IS effective for patients with lumbargo. kn-abstract=˜’ÉÇŠ³ŽÒ12—á‚ð‘Îۂɉ·ò—Ö@‚Ì—Õ°Œø‰Ê‚ɂ‚¢‚ÄŒŸ“¢‚µ‚½¡—Õ°Œø‰Ê‚Ì”»’è‚Í,“ú–{®Œ`ŠO‰ÈŠw‰ï‚̘’ÉŽ¡—ìє»’èŠî€‚ÉŠî‚«,Ž©ŠoÇó,‘¼ŠoÇó,‹y‚Ñ“úí¶Šˆ“®ì‚È‚Ç‚Ì€–Ú‚ð’†S‚É,Ž¡—ÑOŒã‚Å”äŠrŒŸ“¢‚µ‚½¡‚»‚ÌŒ‹‰Ê,Ž©ŠoÇó,“úí¶Šˆ“®ì,‘Œv‚Å‚Í,Ž¡—ÑO‚É”ä‚׎¡—ÃŒã‚É—LˆÓ‚̉ü‘P‚ª‚Ý‚ç‚ꂽ¡‚Ü‚½‰ü‘PŽw”‚â‰ü‘P—¦‚Å‚ÌŒŸ“¢‚Å‚à‰·ò—Ö@‚Ì—LŒø«‚ªŽ¦´‚³‚ꂽ¡”N—î•Ê(60ˈÈã‚Æ60Ë–¢–ž),“ü‰@ŠúŠÔ(80“úˆÈã‚Æ80“ú–¢–ž)•Ê‚Ì ŒŸ“¢‚Å‚Í,65Ë–¢–ž‚ÌÇ—á,80“úˆÈã‚Ì“ü‰@‚ÌÇ—á‚É‚¨‚¢‚Ä,‰ü‘PŽw”,‰ü‘P—¦‚ª,—LˆÓ·‚Í‚Ý‚ç‚ê‚È‚©‚Á‚½‚à‚Ì‚Ì‚æ‚è‚‚¢ŒXŒü‚ª‚Ý‚ç‚ꂽ¡ en-copyright= kn-copyright= en-aut-name=OkamotoMakoto en-aut-sei=Okamoto en-aut-mei=Makoto kn-aut-name=‰ª–{½ kn-aut-sei=‰ª–{ kn-aut-mei=½ aut-affil-num=1 ORCID= en-aut-name=AshidaKozo en-aut-sei=Ashida en-aut-mei=Kozo kn-aut-name=ˆ°“ckŽO kn-aut-sei=ˆ°“c kn-aut-mei=kŽO aut-affil-num=2 ORCID= en-aut-name=YamamotoKazuhiko en-aut-sei=Yamamoto en-aut-mei=Kazuhiko kn-aut-name=ŽR–{˜a•F kn-aut-sei=ŽR–{ kn-aut-mei=˜a•F aut-affil-num=3 ORCID= en-aut-name=IwagakiNaofumi en-aut-sei=Iwagaki en-aut-mei=Naofumi kn-aut-name=ŠâŠ_®Žj kn-aut-sei=ŠâŠ_ kn-aut-mei=®Žj aut-affil-num=4 ORCID= en-aut-name=TsugenoHirofumi en-aut-sei=Tsugeno en-aut-mei=Hirofumi kn-aut-name=’Ñ–ì_Žj kn-aut-sei=’Ñ–ì kn-aut-mei=_Žj aut-affil-num=5 ORCID= en-aut-name=HosakiYasuhiro en-aut-sei=Hosaki en-aut-mei=Yasuhiro kn-aut-name=•Ûè‘×O kn-aut-sei=•Ûè kn-aut-mei=‘×O aut-affil-num=6 ORCID= en-aut-name=MifuneTakashi en-aut-sei=Mifune en-aut-mei=Takashi kn-aut-name=Œäät®Žu kn-aut-sei=Œäät kn-aut-mei=®Žu aut-affil-num=7 ORCID= en-aut-name=MitsunobuFumihiro en-aut-sei=Mitsunobu en-aut-mei=Fumihiro kn-aut-name=Œõ‰„•¶—T kn-aut-sei=Œõ‰„ kn-aut-mei=•¶—T aut-affil-num=8 ORCID= en-aut-name=TanizakiYoshiro en-aut-sei=Tanizaki en-aut-mei=Yoshiro kn-aut-name=’J蟘N kn-aut-sei=’Jè kn-aut-mei=Ÿ˜N aut-affil-num=9 ORCID= en-aut-name=TadaShinya en-aut-sei=Tada en-aut-mei=Shinya kn-aut-name=‘½“cT–ç kn-aut-sei=‘½“c kn-aut-mei=T–ç aut-affil-num=10 ORCID= en-aut-name=HaradaMine en-aut-sei=Harada en-aut-mei=Mine kn-aut-name=Œ´“cŽÀª kn-aut-sei=Œ´“c kn-aut-mei=ŽÀª aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=2 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=3 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=4 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=5 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=6 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=7 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=8 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=9 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”•‘®•a‰@ŽO’©•ª‰@“à‰È affil-num=10 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰È affil-num=11 en-affil= kn-affil=‰ªŽR‘åŠwˆãŠw•”‘æ“ñ“à‰È en-keyword=˜’ÉÇ (lumbargo) kn-keyword=˜’ÉÇ (lumbargo) en-keyword=‰·ò—Ö@ (spa therapy) kn-keyword=‰·ò—Ö@ (spa therapy) en-keyword=˜’ÉŽ¡—Ô»’èŠî€ (scoring system based on the standard judgement of therapy for lumbargo) kn-keyword=˜’ÉŽ¡—Ô»’èŠî€ (scoring system based on the standard judgement of therapy for lumbargo) END start-ver=1.4 cd-journal=joma no-vol=68 cd-vols= no-issue= article-no= start-page=45 end-page=50 dt-received= dt-revised= dt-accepted= dt-pub-year=1997 dt-pub=199712 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=‹CŠÇŽxšb‘§Š³ŽÒ‚É‚¨‚¯‚阒ŊC–Èœœ‰–—Ê‚ÆҒň³”—œÜ‚Ì—Õ°“I“Á’¥ kn-title=Determinants of trabecular bone mineral density of the lumber spines and vertebral fracture in patients with bronchial asthma en-subtitle= kn-subtitle= en-abstract=‘ÎÛ‚Í‹CŠÇŽxšb‘§75Ç—á¡‚±‚Ì‚¤‚¿44—á‚̓XƒeƒƒCƒhˆË‘¶«“Ǘá‚Å‚ ‚Á‚½¡35Ç—á‚ɂ‚¢‚Ä‚Í,0.5”N‚©‚ç4”NŠÔ(•½‹Ï:2.6}1.3”NŠÔ)‚ÌŒoŽž“IŠÏŽ@‚à‚¨‚±‚È‚í‚ꂽ¡‚±‚ê‚ç‚ÌÇ—á‚Ìœ‰–—ʂɉe‹¿‚ð‹y‚Ú‚·ˆöŽq‚ɂ‚¢‚ÄŒŸ“¢‚ð‚¨‚±‚È‚Á‚½¡‚—îŽÒ,—«‚É—LˆÓ‚Ȓᜉ–—Ê‚ð”F‚ß‚½¡d‰ñ‹A•ªÍ‚É‚Ä”N—î,«•Ê,ŒoŒû•›tƒXƒeƒƒCƒh“Š—^‘—Ê‚È‚Ç‚Ì€–Ú‚Éœ‰–—Ê‚Æ—LˆÓ‚ÈŠÖ˜A‚ª”F‚ß‚ç‚ꂽ¡‚Ü‚½,35Ç—á’†5—á‚ÉҒň³”—œÜ‚ª”­¶‚µ,‚¢‚¸‚ê‚àœ‰–—Ê‚ª’á‚­,‚—îŽÒ,—«,’·ŠúƒXƒeƒƒCƒh“à•ž—á‚Å‚ ‚Á‚½¡‚±‚ê‚ç‚Ì‚±‚Æ‚©‚ç‹CŠÇŽxšb‘§Š³ŽÒ‚É‚¨‚¢‚Ä‚Í,—«,‚—îŽÒ,’·ŠúƒXƒeƒƒCƒh“à•ž—á‚Éœ‰–—ÊŒ¸­‚âҒň³”—œÜ‚̃ŠƒXƒN‚ª‚‚¢‚Æl‚¦‚ç‚ꂽ¡‚Ü‚½,ƒXƒeƒƒCƒh‘±”­«œ‘eé Ç‚Ì”­¶‚É‚Í,ƒXƒeƒƒCƒh‚ÌŒ»Ý‚̈ê“ú“à•ž—Ê‚æ‚è‚à‚±‚ê‚Ü‚Å‚Ì‘ÏŽZ“à•ž—Ê‚ªd—v‚Æl‚¦‚ç‚ꂽ¡ kn-abstract=Clinical risk factors associated with the development of osteoporosis and vertebral fractures were evaluated in patients with asthma in relation to sex, age, and dose of glucocorticoids (GC). In 75 asthmatic patients including 44 steroid-dependent asthma, the bone mineral density (BMD) of the lumber spines was measured by quantitative computed tomography (QCT). Thirty five patients of them were followed up with radiographs over a period of 0.5 to 4 years (average: 2.6}1.3 years). The BMD was significantly lower in older (p