| ID | 40680 |
| FullText URL | |
| Title Alternative | Studies on the reactivity of human basophilic leukocytes Part 2. Correlation between morphological changes of human basophilic leukocytes and histamine release after stimulation with Ca. ionophore A23187
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| Author |
Nakagawa, Saburo
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| Abstract | Morphological changes in human basophils from 11 atopic asthmatics were observed in whole blood smears with respect to histamine release after the cells were challenged by Ca. ionophore A23187. A decreased number of basophils and granules in the cells as well as increase in cell diameters were observed upon histamine release after stimulation with Ca. ionophore A23187. Compared to cell reactions to antigen or anti-IgE, Ca. ionophore A23187 produced both more gradual morphological changes and histamine release and induced greater increases in the diameter of the basophils. No change in the ratio of the short to long axis diameter was observed after stimulation with Ca. ionophore A23187. The results suggest that basophils do not show any increased mobility upon stimulaion with Ca. ionophore A23187, though antigen and anti-IgE stimulation induces increased motility in these cells.
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| Keywords | 気管支喘息
好塩基球
ヒスタミン遊離
形態的変化
Ca. ionophore A23187
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| Published Date | 1990-10
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume102
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| Issue | issue9-10
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 1127
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| End Page | 1134
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/102/9-10/102_9-10_1127/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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