| ID | 17009 |
| Eprint ID | 17009
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| FullText URL | |
| Title Alternative | Studies on hairy cell leukemia Part Ⅰ. Establishment of a hairy cell leukemia line and its characteristics
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| Author |
Hikita, Takao
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| Abstract | A hairy cell leukemia (HCL) line, ZK-H, and a normal lymphoblastoid cell line, ZK-N, were established from the peripheral blood of a 69-year-old male patient. The ZK-H cells and the patient's original hairy cells shared the same surface properties; both possessed membrane-bound IgG with kappa light chains and villous surface structures. The ZK-N cells were devoid of villous surface structures and polyclonal in that they consisted of cells having different membrane-bound heavy and light chains. Both the ZK-H and ZK-N lines carried Epstein Barr virus (EBV)-determined nuclear antigen, but the patient's fresh leukemic cells lacked this antigen. The ZK-H line had a hyperdiploid chromosome constitution of 47 and trisomy No. 2, but the ZK-N line had a normal chromosome constitution. The presence of membrane-bound immunoglobulin and B-cell tropic EBV in the ZK-H line provides evidence of the B-cell nature of HCL in this patient.
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| Keywords | hairy cell leckemia
組織培養
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| Published Date | 1980-04-30
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume92
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| Issue | issue3-4
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 289
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| End Page | 299
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/92/3-4/92_3-4_289/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
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