このエントリーをはてなブックマークに追加
ID 62286
Author
Shiotani, Toshio Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences
Sugimoto, Seiichiro Organ Transplant Center, Okayama University Hospital ORCID Kaken ID publons researchmap
Yamamoto, Haruchika Department of General Thoracic Surgery, Okayama University Hospital
Miyoshi, Kentaroh Department of General Thoracic Surgery, Okayama University Hospital Kaken ID
Otani, Shinji Department of General Thoracic Surgery, Okayama University Hospital
Suzawa, Ken Department of General Thoracic Surgery, Okayama University Hospital ORCID Kaken ID researchmap
Yamamoto, Hiromasa Department of General Thoracic Surgery, Okayama University Hospital ORCID Kaken ID publons researchmap
Okazaki, Mikio Department of General Thoracic Surgery, Okayama University Hospital
Yamane, Masaomi Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Kaken ID researchmap
Toyooka, Shinichi Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Abstract
Purpose
Decreased irisin levels may be associated with the development of emphysema. Similarly, emphysematous changes may develop in patients with chronic lung allograft dysfunction (CLAD) after living-donor lobar lung transplantation (LDLLT). We investigated the severity of emphysematous changes and the relationship between irisin levels and CLAD after bilateral LDLLT and cadaveric lung transplantation (CLT).

Methods
The subjects of this retrospective study were 59 recipients of bilateral LDLLT (n = 31) or CLT (n = 28), divided into a non-CLAD group (n = 41), a LDLLT-CLAD group (n = 11), and a CLT-CLAD group (n = 7). We compared the severity of emphysematous changes, the skeletal muscle mass, and the plasma irisin levels among the groups.

Results
The emphysematous changes were significantly more severe in the LDLLT-CLAD and CLT-CLAD groups (p = 0.046 and 0.036), especially in patients with bronchiolitis obliterans syndrome (BOS), than in the non-CLAD group. Although the skeletal muscle mass was similar in all the groups, the plasma irisin levels were significantly lower in the LDLLT-CLAD group (p = 0.022), especially in the patients with BOS after LDLLT, than in the non-CLAD group.

Conclusion
Emphysematous changes and lower levels of plasma irisin were associated with CLAD, especially in patients with BOS, after bilateral LDLLT.
Keywords
chronic lung allograft dysfunction
emphysema
irisin
living-donor
lung transplantation
Note
This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-021-02339-w
This fulltext is available in July 2022.
Published Date
2021-7-12
Publication Title
Surgery Today
Publisher
Springer Science and Business Media LLC
ISSN
0941-1291
NCID
AA10824685
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© Springer Nature Singapore Pte Ltd. 2021
File Version
author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1007/s00595-021-02339-w
Funder Name
Japan Society for the Promotion of Science
助成番号
19K09305
20K1774702
Open Access (Publisher)
non-OA
Open Archive (publisher)
Non-OpenArchive