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ID 61473
Author
Yamamoto, Haruchika Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Sugimoto, Seiichiro Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital ORCID Kaken ID publons researchmap
Soh, Junichi Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Shiotani, Toshio Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Miyoshi, Kentaroh Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital Kaken ID
Otani, Shinji Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Okazaki, Mikio Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital
Yamane, Masaomi Kaken ID researchmap
Toyooka, Shinichi Department of General Thoracic Surgery and Organ Transplant Center, Okayama University Hospital ORCID Kaken ID publons researchmap
Abstract
Purpose
The prognostic nutritional index (PNI), calculated based on the serum albumin levels and the total lymphocyte count, has been identified as a predictor of clinical outcomes in various fields of surgery. In this study, we investigated the relationship between the PNI and the lung allocation score (LAS) as well as the impact of the PNI on the outcomes of both cadaveric lung transplantation (CLT) and living-donor lobar lung transplantation (LDLLT).
Methods
We reviewed retrospective data for 127 recipients of lung transplantation (LT), including 71 recipients of CLT and 56 recipients of LDLLT.
Results
The PNI was correlated significantly and negatively with the LAS (r = − 0.40, P = 0.0000037). Multivariate analysis revealed that age (P = 0.00093), BMI (P = 0.00087), and PNI (P = 0.0046) were independent prognostic factors of a worse outcome after LT. In a subgroup analysis, survival after both CLT (P = 0.015) and LDLLT (P = 0.041) was significantly worse in the low PNI group than in the high PNI group.
Conclusion
Preoperative nutritional evaluations using the PNI can assist with the assessment of disease severity in LT recipients and may predict survival after both CLT and LDLLT.
Keywords
Prognostic nutrition index
Lung allocation score
Lung transplantation
Living-donor lobar lung transplantation
Outcome
Note
“This is a post-peer-review, pre-copyedit version of an article published in Surgery Today. The final authenticated version is available online at: https://doi.org/10.1007/s00595-021-02244-2.
This fulltext is available in Feb. 2022.
Published Date
2021-2-13
Publication Title
Surgery Today
Publisher
Springer
ISSN
0941-1291
NCID
AA10824685
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
File Version
author
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1007/s00595-021-02244-2
Funder Name
Japan Society for the Promotion of Science
助成番号
19K09305