| FullText URL | fulltext.pdf |
|---|---|
| Author | Kidani, Naoya| Hishikawa, Tomohito| Hiramatsu, Masafumi| Nishihiro, Shingo| Kin, Kyohei| Takahashi, Yu| Murai, Satoshi| Sugiu, Kenji| Yasuhara, Takao| Miyazaki, Ikuko| Asanuma, Masato| Date, Isao| |
| Keywords | apoptosis cerebral blood flow crossed cerebellar diaschisis ischemic stroke oxidative stress |
| Published Date | 2020-06-10 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume21 |
| Issue | issue11 |
| Publisher | MDPI |
| Start Page | 4137 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 by the authors. |
| File Version | publisher |
| PubMed ID | 32531947 |
| DOI | 10.3390/ijms21114137 |
| Web of Science KeyUT | 000543400300399 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms21114137 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kin, Kyohei| Yasuhara, Takao| Kameda, Masahiro| Date, Isao| |
| Keywords | animal model alpha-synuclein DJ-1 neurotoxin Parkin Parkinson's disease pesticide PINK1 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine |
| Published Date | 2019-10-30 |
| Publication Title | International Journal of Molecular Sciences |
| Volume | volume20 |
| Issue | issue21 |
| Publisher | MDPI |
| Start Page | E5402 |
| ISSN | 1422-0067 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors. |
| File Version | publisher |
| PubMed ID | 31671557 |
| DOI | 10.3390/ijms20215402 |
| Web of Science KeyUT | 000498946100160 |
| Related Url | isVersionOf https://doi.org/10.3390/ijms20215402 |
| JaLCDOI | 10.18926/AMO/55302 |
|---|---|
| FullText URL | 71_4_263.pdf |
| Author | Toyoshima, Atsuhiko| Yasuhara, Takao| Date, Isao| |
| Abstract | To date, many animal studies have indicated the neuroprotective effects of mesenchymal stem cell (MSC) transplantation in ischemic stroke. Several clinical studies have also revealed the safety, feasibility, and neuroprotective effects in ischemic stroke patients. In this review, we present the main approaches of MSC transplantation in ischemic stroke, the mechanisms of MSC therapy, and the current clinical studies on MSC transplantation in ischemic stroke patients. We also explore the safety of MSC transplantation and conclude that MSC therapy will play an important role in the future treatment of ischemic stroke. The optimal timing, approach, and cell dose in the transplantation are important issues for successful clinical application. |
| Keywords | mesenchymal stem cell ischemic stroke cell transplantation clinical trial |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-08 |
| Volume | volume71 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 263 |
| End Page | 268 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28824181 |
| JaLCDOI | 10.18926/AMO/54987 |
|---|---|
| FullText URL | 71_2_179.pdf |
| Author | Nosaka, Nobuyuki| Tsukahara, Kohei| Knaup, Emily| Yabuuchi, Toshihiko| Kikkawa, Tomonobu| Fujii, Yosuke| Yashiro, Masato| Yasuhara, Takao| Okada, Ayumi| Ugawa, Toyomu| Nakao, Atsunori| Tsukahara, Hirokazu| Date, Isao| |
| Abstract | Newly published clinical practice guidelines recommend intracranial pressure (ICP) monitoring in critical care for the management of pediatric acute encephalopathy (pAE), but the utility of ICP monitoring for pAE has been poorly studied. We recently performed direct ICP monitoring for two patients. We observed that although the direct ICP monitoring had clinical benefits with less body weight gain and no vasopressor use in both cases, this monitoring technique is still invasive. Future studies should determine the utility of non-invasive ICP monitoring systems in pAE to further improve the quality of intensive-care management. |
| Keywords | cerebral perfusion encephalopathy child intracranial pressure neurological intensive care |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 179 |
| End Page | 180 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420900 |
| JaLCDOI | 10.18926/AMO/54813 |
|---|---|
| FullText URL | 70_6_493.pdf |
| Author | Yasuhara, Takao| Kuwahara, Ken| Sasada, Susumu| Toyoshima, Atsuhiko| Morimoto, Jun| Kin, Kyohei| Manabe, Hiroaki| Miyoshi, Yasuyuki| Kusumegi, Akira| Takahashi, Yuichiro| Ito, Kiyoshi| Date, Isao| |
| Abstract | Unexpected injuries can have a profound effect on a surgeonʼs performance and thus on patients and surgical departments. Here we describe a technique for performing surgery in the standing position, as done by a surgeon with an Achilles tendon rupture. During his prescribed 45-day non-weight-bearing period for the left ankle after surgery for an Achilles tendon rupture, the surgeon was able to participate in 15 surgeries as an operator or assistant, due to his use of a combination of injured-leg genuflection on a stool and a ʻSurgical Body Supportʼ device. Similarly injured surgeons may benefit from such support. |
| Keywords | Achilles tendon rupture electromyogram genuflection injured leg standing position |
| Amo Type | Short Communication |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-12 |
| Volume | volume70 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 493 |
| End Page | 496 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28003675 |
| Author | Wakamori, Takaaki| Agari, Takashi| Yasuhara, Takao| Kameda, Masahiro| Kondo, Akihiko| Shinko, Aiko| Sasada, Susumu| Sasaki, Tatsuya| Furuta, Tomohisa| Date, Isao| |
|---|---|
| Published Date | 2014-04 |
| Publication Title | Parkinsonism and Related Disorders |
| Volume | volume20 |
| Issue | issue4 |
| Content Type | Journal Article |
| Author | Tayra, Judith Thomas| Kameda, Masahiro| Yasuhara, Takao| Agari, Takashi| Kadota, Tomohito| Wang, Feifei| Kikuchi, Yoichiro| Liang, Hanbai| Shinko, Aiko| Wakamori, Takaaki| Vcelar, Brigitta| Weik, Robert| Date, Isao| |
|---|---|
| Published Date | 2013-03-28 |
| Publication Title | Brain Research |
| Volume | volume1502 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/50414 |
|---|---|
| FullText URL | 67_3_197.pdf |
| Author | Yasuhara, Takao| Takahashi, Yuichi| Kumamoto, Shinji| Nakahara, Masayuki| Yoneda, Kotaro| Niimura, Tatsuomi| Tanoue, Takashi| Kusumegi, Akira| Sennari, Takashi| Hijikata, Yasukazu| Manabe, Hiroaki| Miyoshi, Yasuyuki| Date, Isao| Ogawa, Koichi| Nishida, Kenki| |
| Abstract | Some cases with lumbar degenerative diseases require multi-level fusion surgeries. At our institute, 27 and 4 procedures of 3- and 4-level fusion were performed out of a total 672 posterior lumbar interfusions (PLIFs) on patients with lumbar degenerative disease from 2005 to 2010. We present 2 osteoporotic patients who developed proximal vertebral body fracture after 4-level fusion. Both cases presented with gait disability for leg pain by degenerative lumbar scoliosis and canal stenosis at the levels of L1/2-4/5. After 4-level fusion using L1 as the upper instrumented vertebra, proximal vertebral body fractures were found along with the right pedicle fractures of L1 in both cases. One of these patients, aged 82 years, was treated as an outpatient using a hard corset for 24 months, but the fractures were exacerbated over time. In the other patient, posterolateral fusion was extended from Th10 to L5. Both patients can walk alone and have been thoroughly followed up. In both cases, the fracture of the right L1 pedicle might be related to the subsequent fractures and fusion failure. In consideration of multi-level fusion, L1 should be avoided as an upper instrumented vertebra to prevent junctional kyphosis, especially in cases with osteoporosis and flat back posture. |
| Keywords | degenerative lumbar scoliosis osteoporosis pedicle fracture posterior lumbar interbody fusion vertebral body fracture |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2013-06 |
| Volume | volume67 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 197 |
| End Page | 202 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2013 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 23804144 |
| Web of Science KeyUT | 000320747900010 |
