| JaLCDOI | 10.18926/AMO/54497 |
|---|---|
| FullText URL | 70_4_229.pdf |
| Author | Hishikawa, Tomohito| Sugiu, Kenji| Date, Isao| |
| Abstract | About 5 decades have passed since the concept of moyamoya disease (MMD) was established in Japan. In that time, many clinical MMD studies have been performed from several different points of view, such as epidemiology, pathophysiology, surgical procedures, and prognosis. In addition, rapid developments in MMD genetic analysis have occurred. In light of all this activity, clinicians must continually update their knowledge of MMD in order to improve the prognosis of MMD patients. In this review article, we summarize the clinical MMD studies and introduce cutting-edge findings regarding MMD. |
| Keywords | clinical research moyamoya disease |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2016-08 |
| Volume | volume70 |
| Issue | issue4 |
| Publisher | Okayama University Medical School |
| Start Page | 229 |
| End Page | 236 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 27549666 |
| Web of Science KeyUT | 000384748600001 |
| Title Alternative | Review of the 31st Annual Meeting of the Japanese Society for NeuroEndovascular Therapy (JSNET 2015 Okayama) |
|---|---|
| FullText URL | 128_151.pdf |
| Author | Sugiu, Kenji| |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2016-08-01 |
| Volume | volume128 |
| Issue | issue2 |
| Start Page | 151 |
| End Page | 153 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.128.151 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2016 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.128.151 |
| NAID | 130005262641 |
| Author | Itami, Hisakazu| Tokunaga, Koji| Okuma, Yu| Hishikawa, Tomohito| Sugiu, Kenji| Ida, Kentaro| Date, Isao| |
|---|---|
| Published Date | 2013-09 |
| Publication Title | Neuroradiology |
| Volume | volume55 |
| Issue | issue9 |
| Content Type | Journal Article |
| Author | Hayase, Hitoshi| Tokunaga, Koji| Nakayama, Toshio| Sugiu, Kenji| Nishida, Ayumi| Arimitsu, Seiji| Hishikawa, Tomohito| Ono, Shigeki| Ohta, Makoto| Date, Isao| |
|---|---|
| Published Date | 2013-04-01 |
| Publication Title | 岡山医学会雑誌 |
| Volume | volume125 |
| Issue | issue1 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/31858 |
|---|---|
| FullText URL | fulltext.pdf |
| Author | Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao| |
| Abstract | Many studies have shown that a motif of 11 consecutive arginines (11R) is one of the most effective protein transduction domains (PTD) for introducing proteins into the cell membrane. By conjugating this "11R", all sorts of proteins can effectively and harmlessly be transferred into any kind of cell. We therefore examined the transduction efficiency of 11R in cerebral arteries and obtained results showing that 11R fused enhanced green fluorescent protein (11R-EGFP) immediately and effectively penetrated all layers of the rat basilar artery (BA), especially the tunica media. This method provides a revolutionary approach to cerebral arteries and ours is the first study to demonstrate the successful transductionof a PTD fused protein into the cerebral arteries. In this review, we present an outline of our studies and other key studies related to cerebral vasospasm and 11R, problems to be overcome, and predictions regarding future use of the 11R protein transduction method for cerebral vasospasm (CV). |
| Keywords | cerebral vasospasm 11 consecutive arginines (11R) enhanced green fluorescent protein (EGFP) |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2009-02 |
| Volume | volume63 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 7 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 19247417 |
| Web of Science KeyUT | 000263730300001 |
| Title Alternative | Novel protein transduction method for cerebral arteries using 11R |
|---|---|
| FullText URL | 120_129.pdf |
| Author | Ogawa, Tomoyuki| Ono, Shigeki| Ichikawa, Tomotsugu| Arimitsu, Seiji| Onoda, Keisuke| Tokunaga, Koji| Sugiu, Kenji| Tomizawa, Kazuhito| Matsui, Hideki| Date, Isao| |
| Keywords | cerebral vasospasm 11R protein transduction method |
| Publication Title | 岡山医学会雑誌 |
| Published Date | 2008-08-01 |
| Volume | volume120 |
| Issue | issue2 |
| Start Page | 129 |
| End Page | 133 |
| ISSN | 00301558 |
| language | Japanese |
| Copyright Holders | 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.120.129 |
| NAID | 120002310545 |
| FullText URL | O002986.pdf |
|---|---|
| Author | Sugiu, Kenji| |
| Published Date | 1996-03-25 |
| Content Type | Thesis or Dissertation |
| Grant Number | 乙第2986号 |
| Granted Date | 1996-03-25 |
| Thesis Type | Doctor of Philosophy in Medical Science |
| Grantor | 岡山大学 |
| language | Japanese |
