Okayama University Medical School Acta Medica Okayama 0386-300X 77 1 2023 Effect of a Cyclooxygenase-2 Inhibitor in Combination with (−)-Epigallocatechin Gallate or Polyphenon E on Cisplatin-Induced Lung Tumorigenesis in A/J Mice 65 70 EN Ken Sato Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Nagio Takigawa Department of General Internal Medicine 4, Kawasaki Medical School Toshio Kubo Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Hideki Katayama Department of Medicine, Yamaguchi-Ube Medical Center Daizo Kishino Department of Medicine, Yamaguchi-Ube Medical Center Toshiaki Okada Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Akiko Hisamoto Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Junko Mimoto Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Nobuaki Ochi Department of General Internal Medicine 4, Kawasaki Medical School Tadashi Yoshino Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Hiroshi Ueoka Department of Medicine, Yamaguchi-Ube Medical Center Mitsune Tanimoto Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Yoshionobu Maeda Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Katsuyuki Kiura Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Original Article 10.18926/AMO/64363 We investigated the effects of celecoxib combined with (−)-epigallocatechin-3-gallate (EGCG) or polyphenon E in a cisplatin-induced lung tumorigenesis model. Four-week-old female A/J mice were divided into seven groups: (i) Control, (ii) 150 mg/kg celecoxib (150Cel), (iii) 1,500 mg/kg celecoxib (1500Cel), (iv) EGCG+150 mg/kg celecoxib (EGCG+150Cel), (v) EGCG+1,500 mg/kg celecoxib (EGCG+1500Cel), (vi) polyphenon E+150 mg/kg celecoxib (PolyE+150Cel), and (vii) polyphenon E+1,500 mg/kg celecoxib (PolyE+1500Cel). All mice were administered cisplatin (1.62 mg/kg of body weight, i.p.) 1×/week for 10 weeks and sacrificed at week 30; the numbers of tumors on the lung surface were then determined. The tumor incidence and multiplicity (no. of tumors/mouse, mean±SD) were respectively 95% and 2.15±1.50 in Control, 95% and 2.10±1.29 in 150Cel, 86% and 1.67±1.20 in 1500Cel, 71% and 1.38±1.24 in EGCG+150Cel, 67% and 1.29±1.38 in EGCG+1500Cel, 80% and 1.95±1.36 in PolyE+150Cel, and 65% and 1.05±0.10 in PolyE+1500Cel. The combination of high-dose celecoxib with EGCG or polyphenon E significantly reduced multiplicity in cisplatin-induced lung tumors. No potential conflict of interest relevant to this article was reported.

MDPI Acta Medica Okayama 2072-6694 14 24 2022 The Effect of Pleural Effusion on Prognosis in Patients with Non-Small Cell Lung Cancer Undergoing Immunochemotherapy: A Retrospective Observational Study 6184 EN Tomoka Nishimura Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Eiki Ichihara Department of Allergy and Respiratory Medicine, Okayama University Hospital Toshihide Yokoyama Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital Koji Inoue Department of Respiratory Medicine, Ehime Prefectural Central Hospital Tomoki Tamura Department of Respiratory Medicine, NHO Iwakuni Clinical Center Ken Sato Department of Respiratory Medicine, National Hospital Organization Okayama Medical Center Naohiro Oda Department of Internal Medicine, Fukuyama City Hospital Hirohisa Kano Department of Respiratory Medicine, Japanese Red Cross Okayama Hospital Daizo Kishino Department of Respiratory Medicine, Japanese Red Cross Society Himeji Hospital Haruyuki Kawai Department of Internal Medicine, Okayama Saiseikai General Hospital Masaaki Inoue Department of Chest Surgery, Shimonoseki City Hospital Nobuaki Ochi Department of General Internal Medicine 4, Kawasaki Medical School Nobukazu Fujimoto Department of Respiratory Medicine, Okayama Rosai Hospital Hirohisa Ichikawa Department of Respiratory Medicine, KKR Takamatsu Hospital Chihiro Ando Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Katsuyuki Hotta Center for Innovative Clinical Medicine, Okayama University Hospital Yoshinobu Maeda Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Katsuyuki Kiura Department of Allergy and Respiratory Medicine, Okayama University Hospital Simple Summary Minimal data exists on pleural effusion (PE) for non-small cell lung cancer (NSCLC) patients undergoing combined ICI and chemotherapy. We retrospectively investigated how PE affects survival outcomes in patients with NSCLC undergoing this combined therapy. We identified 478 patients who underwent combined ICI therapy and chemotherapy; 357 patients did not have PE, and 121 patients did have PE. Patients with PE had significantly shorter progression-free survival and overall survival than those without PE. In addition, bevacizumab-containing regimens did not improve the survival outcomes for patients with PE. In conclusion, PE was associated with poor outcomes among patients with NSCLC undergoing combined ICI therapy and chemotherapy. Objectives: Combined immune checkpoint inhibitor (ICI) therapy and chemotherapy has become the standard treatment for advanced non-small-cell lung cancer (NSCLC). Pleural effusion (PE) is associated with poor outcomes among patients with NSCLC undergoing chemotherapy. However, minimal data exists on PE for patients undergoing combined ICI and chemotherapy. Therefore, we investigated how PE affects survival outcomes in patients with NSCLC undergoing this combined therapy. Methods: We identified patients with advanced NSCLC undergoing chemotherapy and ICI therapy from the Okayama Lung Cancer Study Group-Immune Chemotherapy Database (OLCSG-ICD) between December 2018 and December 2020; the OLCSG-ICD includes the clinical data of patients with advanced NSCLC from 13 institutions. Then, we analyzed the treatment outcomes based on the presence of PE. Results: We identified 478 patients who underwent combined ICI therapy and chemotherapy; 357 patients did not have PE, and 121 patients did have PE. Patients with PE had significantly shorter progression-free survival (PFS) and overall survival (OS) than those without PE (median PFS: 6.2 months versus 9.1 months; p < 0.001; median OS: 16.4 months versus 27.7 months; p < 0.001). The negative effect of PE differed based on the patient's programmed cell death-ligand 1 (PD-L1) expression status; with the effect being more evident in patients with high PD-L1 expression. In addition, PFS and OS did not differ between patients who did and did not undergo bevacizumab treatment; thus, bevacizumab-containing regimens did not improve the survival outcomes for patients with PE. Conclusion: PE is associated with poor outcomes among patients with NSCLC undergoing combined ICI therapy and chemotherapy. No potential conflict of interest relevant to this article was reported.

MDPI Acta Medica Okayama 2076-3425 11 6 2021 Parieto-Occipital Alpha and Low-Beta EEG Power Reflect Sense of Agency 743 EN Hani M. Bu-Omer Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University Akio Gofuku Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University Kenji Sato Department of Anesthesiology and Intensive Care Medicine, Kawasaki Medical School Makoto Miyakoshi Swartz Center for Computational Neuroscience, Institute for Neural Computation, University of California San Diego The sense of agency (SoA) is part of psychophysiological modules related to the self. Disturbed SoA is found in several clinical conditions, hence understanding the neural correlates of the SoA is useful for the diagnosis and determining the proper treatment strategies. Although there are several neuroimaging studies on SoA, it is desirable to translate the knowledge to more accessible and inexpensive EEG-based biomarkers for the sake of applicability. However, SoA has not been widely investigated using EEG. To address this issue, we designed an EEG experiment on healthy adults (n = 15) to determine the sensitivity of EEG on the SoA paradigm using hand movement with parametrically delayed visual feedback. We calculated the power spectral density over the traditional EEG frequency bands for ten delay conditions relative to no delay condition. Independent component analysis and equivalent current dipole modeling were applied to address artifact rejection, volume conduction, and source localization to determine the effect of interest. The results revealed that the alpha and low-beta EEG power increased in the parieto-occipital regions in proportion to the reduced SoA reported by the subjects. We conclude that the parieto-occipital alpha and low-beta EEG power reflect the sense of agency. No potential conflict of interest relevant to this article was reported.

Okayama University Medical School Acta Medica Okayama 0386-300X 68 6 2014 Management of Lacerated and Swollen Tongue after Convulsive Seizure with a Mouth Protector: Interprofessional Collaboration Including Dentists in Intensive Care 375 378 EN Reiko Yamanaka Yoshihiko Soga Yoshie Moriya Akemi Okui Tetsuo Takeuchi Kenji Sato Hiroshi Morimatsu Manabu Morita Case Report 10.18926/AMO/53027 We encountered a 74-year-old male patient with tongue laceration after convulsive seizures under intensive care. The tongue showed severe swelling, and the right ventral surface had been lacerated by his isolated and pointed right lower canine. Our university hospital has established a perioperative management center, and is promoting interprofessional collaboration, including dentists, in perioperative management. Dentists collaborating in the perioperative management center took dental impressions, with the support of anesthesiologists who opened the patientʼs jaw under propofol sedation, to produce a mouth protector. By raising the patientʼs bite, the completed mouth protector prevented the isolated tooth from contacting the tongue and protected the lacerated wound. Use of the mouth protector prevented the lacerated tongue from coming into contact with the pointed tooth, and the tongue healed gradually. These findings underscore that interprofessional collaboration including dentists can improve the quality of medical care. No potential conflict of interest relevant to this article was reported.

Okayama University Medical School Acta Medica Okayama 0386-300X 68 6 2014 Living Will Interest and Preferred End-of-life Care and Death Locations among Japanese Adults 50 and over: A Population-based Survey 339 348 EN Hiroyuki Nishie Satoshi Mizobuchi Etsuji Suzuki Kenji Sato Yuichiro Toda Junji Matsuoka Hiroshi Morimatsu Original Article 10.18926/AMO/53023 The main purpose of this study was to determine the relationships between Japanese individualsʼ interest in living wills and their preferred end-of-life care and death locations. Questionnaires were mailed to 1,000 individuals aged ｧ50 to measure these 2 factors. We examined the associations between the respondentsʼ characteristics and their preferred care and death locations by using multinomial logistic regression models. The response rate was 74%. Home was the most frequently preferred place for end-of-life care (64%), and a palliative care unit (PCU) was the most commonly preferred place to die (51%). Living will interest was associated with a preference for care (odds ratio [OR] 4.74, 95% confidence interval [CI] 1.95-12.1) and death (OR 2.75, 95% CI 1.70-4.47) in a PCU rather than a hospital, but it was not associated with the choice between receiving care or dying at home instead of a hospital. We must consider why Japanese people think home death is impracticable. The Japanese palliative care system should be expanded to meet patientsʼ end-of-life needs, and this includes not only facilitating home care but also increasing access to PCU care. No potential conflict of interest relevant to this article was reported.

Okayama University Medical School Acta Medica Okayama 0386-300X 68 6 2014 Mean Lung Pressure during Adult High-Frequency Oscillatory Ventilation: An Experimental Study Using a Lung Model 323 329 EN Takahiro Hirayama Osamu Nagano Naoki Shiba Tetsuya Yumoto Keiji Sato Michihisa Terado Toyomu Ugawa Shingo Ichiba Yoshihito Ujike Original Article 10.18926/AMO/53021 In adult high-frequency oscillatory ventilation (HFOV), stroke volume (SV) and mean lung pressure (PLung) are important for lung protection. We measured the airway pressure at the Y-piece and the lung pressure during HFOV using a lung model and HFOV ventilators for adults (R100 and 3100B). The lung model was made of a 20-liter, airtight rigid plastic container (adiabatic compliance: 19.3ml/cmH₂O) with or without a resistor (20cmH₂O/l/sec). The ventilator settings were as follows: mean airway pressure (MAP), 30cmH2O;frequency, 5-15Hz (every 1Hz);airway pressure amplitude (AMP), maximum;and % of inspiratory time (IT), 50% for R100, 33% or 50% for 3100B. The measurements were also performed with an AMP of 2/3 or 1/3 maximum at 5, 10 and 15Hz. The PLung and the measured MAP were not consistently identical to the setting MAP in either ventilator, and decreasing IT decreased the PLung in 3100B. In conclusion, we must pay attention to the possible discrepancy between the PLung and the setting MAP during adult HFOV. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 00301558 119 1 2007 末梢血行障害による虚血性疼痛に対するモルヒネ内服の効果 57 60 EN Hiroyuki Nishie Satoshi Mizobuchi Takashi Matsusaki Asako Miyake Ryuji Kaku Shinichi Ishikawa Kenji Sato Masaki Matsumi Morita Kiyoshi Peripheral arterial disease often causes ischemic ulcers due to impaired blood flow and consequentially induces intractable pain. For these patients, we have recently begun to administer morphine orally. In this study, we retrospectively examined the effects of oral morphine for the relief of pain caused by peripheral arterial disease. Oral morphine was administered to 17 cases of peripheral arterial disease between January, 2004 and February, 2006. The initial dosage was 5 mg or 10 mg, started on an as-needed basis. After the daily dosage of morphine became constant, we divided the dosage into four or six times a day and administered it regularly. With the exception of one case, a small amount of oral morphine, from 20 mg to 70 mg a day, could alleviate patient's pain. Eight cases had side effects such as nausea, constipation or drowsiness. Oral morphine is effective for pain relief of peripheral arterial disease patients. However, now in Japan, oral morphine, which we can prescribe for those patients with insurance, has a shorter duration of action, so we need to administer slow-release morphine. Oral morphine must be administered carefully because many peripheral arterial disease patients have cardiac disease or renal dysfunction as complications. No potential conflict of interest relevant to this article was reported.

社団法人日本機械学会 Acta Medica Okayama 0387-5016 60 580 1994 低凝固点油滴の凝固を利用した潜熱蓄冷に関する基礎研究 : 第1報,低温水溶液中を浮上するテトラデカン油滴の流動および凝固特性 258 265 EN Hideo Inaba Kenji Sato Flow and solidification characteristics of tetradecane droplets [melting point of 5.8℃, latent heat of 229.1 kJ/kg, density of 770 kg/m^3 (at 6℃) ] ascending in ethlene glycol water solution of 30 weight percent at low temperature were investigated experimentally in order to examine the possibility of a liquid-liquid or liquid-solid direct-contact-type latent cold heat storage system. A new type of solidification rate meter is proposed in the present study. As a result, some interesting freezing behaviors of droplets were observed by the visualization technique. From the measurements of solidification rate of tetradecane droplets, the relationships between the solidification rate and some experimental parameters were clarified. No potential conflict of interest relevant to this article was reported.

社団法人日本機械学会 Acta Medica Okayama 0387-5016 62 593 1996 低凝固点油滴の凝固を利用した潜熱蓄冷に関する基礎研究 : 第2報, 低温水溶液中を浮上するテトラデカン油滴の凝固および熱伝達の無次元整理式 325 332 EN Hideo Inaba Kenji Sato The latent cold heat storage system using the direct-contact freezer with tetradecane oil and ethylene glycol aqueous solution as the latent cold heat storage material and the cold heat transfer medium, respectively, was proposed in a previous paper [Inaba and Sato, Trans. JSME, 60-580 (1994), 4236.]. In this report, in order to obtain practical data for industrial application, nondimensional analysis of the solidification rate of the tetradecane oil droplets and the overall heat transfer coefficient in the freezer was carried out. In this system, the tetradecane oil droplets change from liquid to solid state during ascension in the cold heat transfer medium. Therefore, liquid-liquid and solid-liquid coexisting-type direct-contact heat transfer occurs between the tetradecane oil droplets and the aqueous solution. It can be considered that the flow pattern and heat transfer process are different for the liquid-liquid and the solid-liquid systems. The empirical equations of the solidification rate and the overall heat transfer coefficient were derived for the averaged values for the entire freezer. The optimum operating conditions at which the maximum solidification rate can be achieved were clarified. No potential conflict of interest relevant to this article was reported.

社団法人日本機械学会 Acta Medica Okayama 0387-5016 62 602 1996 低凝固点油滴の凝固を利用した潜熱蓄冷熱に関する基礎研究 : 第3報, 粒状凝固潜熱蓄冷熱材と温空気の直接接触熱交換による放冷熱特性 172 179 EN Hideo Inaba Kenji Sato This paper deals with the cold latent heat energy release characteristics of direct-contact heat exchange between the solidified oil droplets [tetradecane, CH_3(CH_2)_<12>CH_3, melting point5.8℃] and hot air. Hot air is injected into the solidified oil droplet-water mixture layer from the distributor with a number of small circular nozzles. The solidified oil droplet-water mixture layer is fluidized by the air bubbles ascending in the layer, and the air bubbles are cooled from the layer by the direct-contact heat exchange. This paper deals with the characteristics of temperature and humidity of the outlet air from the layer, and time history of the cold heat energy release. The experiments were performed with respect to several experimental parameters, i. e., air flow rate, air temperature and humidity, and the amount of oil droplets and water in the mixture layer. Finally, some empirical correlations for the outlet air temperature and humidity and the finishing time of cold latent heat release were derived in terms of various nondimensional parameters. No potential conflict of interest relevant to this article was reported.

社団法人日本機械学会 Acta Medica Okayama 0387-5016 63 607 1997 低凝固点油滴の凝固を利用した潜熱蓄冷熱に関する基礎研究 : 第4報, 低温水溶液中を浮上するテトラデカン油滴の流動および凝固特性に関する数値計算 267 274 EN Hideo Inaba Kenji Sato This paper proposes a numerical calculation method to predict solidification characteristics of paraffin oil droplets (tetradecane, CH_3(CH_2)_12CH_3,melting point is 5.8℃, diameter is 4〜6mm) ascending in a cold water solution (mixture of ethylene glycol [CH_2OH・CH_2OH] and water, temperature is -2〜-10℃) by buoyancy. The oil droplets start to ascend with several initial velocities and initial temperatures (10〜60℃) in the water solution. The oil droplets are decelerated by hydraulic resistance of the water solution. The water solution flows vertically downward at a low velocity of 0.1 m/s. The temperature of the oil droplet decreases due to direct-contact heat transfer with the cold water solution, and the oil droplet starts to solidify when its surface temperature reaches the freezing point. The solidification rate of the oil droplet is calculated based on a combination of flow behavior and solidification characteristics of the oil droplet. As a result, the motion of the oil droplet, the completion height and time for solidification are determined. The parameters used are the diameter, initial velocity and initial temperature of the oil droplet, and temperature and velocity of water solution. No potential conflict of interest relevant to this article was reported.

社団法人日本機械学会 Acta Medica Okayama 0387-5016 63 607 1997 低凝固点油滴の凝固を利用した潜熱蓄冷熱に関する基礎研究 : 第5報, 低温水溶液流速を変化させた場合の浮上油滴の流動および凝固特性 275 282 EN Hideo Inaba Kenji Sato Flow and solidification characteristics of tetradecane droplets [melting point of 5.8℃, latent heat of 229.1 kJ/kg, density of 770 kg/m^3 (at 6℃)] ascending in ethylene glycol water solution of 30 mass percent at low temperature were investigated experimentally in order to examine the existence of a liquid-liquid or liquid-solid direct-contact-type latent cold heat storage system. Some interesting freezing behaviors of droplets were observed under the conditions of various water solution flow velocities and oil-injection nozzle diameters by the visualization technique. Eventually, the relation-ships between the solidification rate and some experimental parameters were clarified. No potential conflict of interest relevant to this article was reported.

社団法人日本機械学会 Acta Medica Okayama 0387-5016 68 666 2002 ワイヤーコイルを用いた流動抵抗低減用界面活性剤添加水の直円管内熱伝達促進 191 198 EN Hideo Inaba Naoto Haruki Toru Nakata Akihiko Horibe Naoyuki Furumoto Kenji Sato This paper has dealt with the heat transfer enhancement of flowing water with flow drag reduction additive into a heat transfer tube by inserting wire coils. The non-ion type surfactant was used as the additive to decrease the pipe flow resistance for the heat energy transport system. However, the decrease in the flow resistance was allowed to reduce the heat transfer coefficient in the heat transfer tube. Some kinds of wire coils having different diameters were tried to enhance the heat transfer in the heat transfer tube. The effects of wire coils on the pipe friction and the heat transfer coefficients were elucidated under various experimental parameters of flow velocity, wire coil diameter, pitch and length. No potential conflict of interest relevant to this article was reported.

社団法人日本機械学会 Acta Medica Okayama 0387-5016 71 702 2005 直円管内を流動する界面活性剤添加有機プラインの流動抵抗と熱伝達挙動 573 580 EN Naoto Haruki Hideo Inaba Akihiko Horibe Shinji Tanaka Toru Nakata Kenji Sato The flow drag and heat transfer reduction effects of brine flow with drag reduction surfactants have been investigated from the viewpoint of the effective energy consumption in an industrial cooling system. In this study, Oleyldihy-droxyetyl Amine Oxide (ODEAO) of non-ion surfactant was used as a drag reduction surfactant additive, and Ethylene Glycol (EG) was used as a organic brine. It was found that the viscosity of EG brine with ODEAO had the non-Newtonian behavior. The flow friction coefficient and mean forced convection heat transfer coefficient of the EG brine with ODEAO in a straight pipe were measured for each parameter of concentration of EG, concentration of ODEAO and temperature of the brine with ODEAO. The obtained experimental results indicated that the EG brine with ODEAO exerted an influence on the flow drag and heat transfer reduction. No potential conflict of interest relevant to this article was reported.

Acta Medica Okayama 2000 Effects of non-depolarizing neuromuscular blocking agents on norepinephrine release from human atrial tissue obtained during cardiac surgery EN No potential conflict of interest relevant to this article was reported.

岡山大学農学部 Acta Medica Okayama 0474-0254 54 1 1979 Effect of Fungicides, Benomyl and Thiram on Soil Microflora and Some Inhabitant Fungi 1 8 EN Hachiro Oku Kazuo Oki Tomonori Shiraishi Kenji Sato Seiji Ouchi Effects of Benomyl and Thiram on the soil microflora and some soil inhabitant fungi were studied using the_ soil (sandy loam) of the experimental field, Okayama University. Under field conditions, heavy application of Benomyl did not affect significantly the soil microflora. Thiram, however, reduced the fungal population in soil to 1/6 at the next day of treatment, but recovered to the normal level after 6 days. Under laboratory conditions, both fungicides did not affect soil microflora. Population of Benomyl-to lerant fungi was about 1/10 of the total fungi and increased slightly in the field soil by treatment with Benomyl at the later stage of experiment during June to October. Neither Thiram-tolerant fungus nor bacterium was found in both Thiram-treated and non-treated soils. A fungus highly tolerant to Benomyl was isolated and identified as Aspergillus versicolor, and found to not have the metabolic activity to degrade BCM. The absorption of BCM by the mycelia of this tolerant fungus, A. versicolor, was less than half of the BCM-sensitive one, such as Cladosporium harbarum. No potential conflict of interest relevant to this article was reported.