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Author Tachibana, Kota| Tang, Nina| Urakami, Hitoshi| Kajita, Ai| Kobashi, Mina| Nomura, Hayato| Sasakura, Minori| Sugihara, Satoru| Jiang, Fan| Tomonobu, Nahoko| Sakaguchi, Masakiyo| Ouchida, Mamoru| Morizane, Shin|
Keywords psoriasis vulgaris interleukin (IL) 23 IL-39 p19 Epstein-Barr virus-induced (EBI) 3 tildrakizumab
Published Date 2021-11-23
Publication Title International Journal Of Molecular Sciences
Volume volume22
Issue issue23
Publisher MDPI
Start Page 12659
ISSN 1422-0067
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2021 by the authors.
File Version publisher
PubMed ID 34884474
DOI 10.3390/ijms222312659
Web of Science KeyUT 000735457700001
Related Url isVersionOf https://doi.org/10.3390/ijms222312659
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Author He, Fang| Matsumoto, Yoshinori| Asano, Yosuke| Yamamura, Yuriko| Katsuyama, Takayuki| Rose, Jose La| Tomonobu, Nahoko| Komalasari, Ni Luh Gede Yoni| Sakaguchi, Masakiyo| Rottapel, Robert| Wada, Jun|
Keywords ABL-Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion
Note A Corrigendum on RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion By He F, Matsumoto Y, Asano Y, Yamamura Y, Katsuyama T, Rose JL, Tomonobu N, Komalasari NLGY, Sakaguchi M, Rottapel R and Wada J (2021). Front. Oncol. 11:665273. doi: 10.3389/fonc.2021.665273<br> Erratum for https://ousar.lib.okayama-u.ac.jp/62214|
Published Date 2021-07-20
Publication Title Frontiers In Oncology
Volume volume11
Publisher Frontiers Media SA.
Start Page 729192
ISSN 2234-943X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, Rose,Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.
File Version publisher
PubMed ID 34354958
DOI 10.3389/fonc.2021.729192
Web of Science KeyUT 000680472200001
Related Url isVersionOf https://doi.org/10.3389/fonc.2021.729192
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Author He, Fang| Matsumoto, Yoshinori| Asano, Yosuke| Yamamura, Yuriko| Katsuyama, Takayuki| La Rose, Jose| Tomonobu, Nahoko| Komalasari, Ni Luh Gede Yoni| Sakaguchi, Masakiyo| Rottapel, Robert| Wada, Jun|
Keywords ABL Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion
Note Erratum in https://ousar.lib.okayama-u.ac.jp/62331|
Published Date 2021-05-31
Publication Title Frontiers In Oncology
Volume volume11
Publisher Frontiers Media S.A.
Start Page 665273
ISSN 2234-943X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, La Rose, Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.
File Version publisher
PubMed ID 34136397
NAID 120007089841
DOI 10.3389/fonc.2021.665273
Web of Science KeyUT 000661158800001
Related Url isVersionOf https://doi.org/10.3389/fonc.2021.665273
FullText URL fulltext20210630-1.pdf
Author Nakamura, Kazufumi| Akagi, Satoshi| Ejiri, Kentaro| Yoshida, Masashi| Miyoshi, Toru| Sakaguchi, Masakiyo| Amioka, Naofumi| Suastika, Luh Oliva Saraswati| Kondo, Megumi| Nakayama, Rie| Takaya, Yoichi| Higashimoto, Yuichiro| Fukami, Kei| Matsubara, Hiromi| Ito, Hiroshi|
Keywords pulmonary artery smooth muscle cells RAGE aptamer
Note This is an Accepted Manuscript published by Elsevier.<br> ©2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/|
Published Date 2020-12-30
Publication Title Journal of Cardiology
Volume volume78
Issue issue1
Publisher Elsevier
Start Page 12
End Page 16
ISSN 09145087
NCID AN10070473
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
File Version author
PubMed ID 33386219
DOI 10.1016/j.jjcc.2020.12.009
Web of Science KeyUT 000661421700002
Related Url isVersionOf https://doi.org/10.1016/j.jjcc.2020.12.009
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Author Bajkowska, Karolina| Sumardika, I. Wayan| Tomonobu, Nahoko| Chen, Youyi| Yamamoto, Ken-ichi| Kinoshita, Rie| Murata, Hitoshi| Gede Yoni Komalasari, Ni Luh| Jiang, Fan| Yamauchi, Akira| Winarsa Ruma, I. Made| Kasano-Camones, Carlos Ichiro| Inoue, Yusuke| Sakaguchi, Masakiyo|
Keywords Lung cancer Metastasis Epithelial-mesenchymal transition Solute carrier family 22 member 18 antisense S100A8/A9 Neuroplastin
Published Date 2020-07
Publication Title Biochemistry and Biophysics Reports
Volume volume22
Publisher Elsevier
Start Page 100768
ISSN 24055808
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors
File Version publisher
PubMed ID 32490214
DOI 10.1016/j.bbrep.2020.100768
Related Url isVersionOf https://doi.org/10.1016/j.bbrep.2020.100768
JaLCDOI 10.18926/AMO/60371
FullText URL 74_4_327.pdf
Author Yamamoto, Ken-ichi| Kagawa, Hiroko| Arimoto, Sakae| Tan, Xian Wen| Yasui, Kento| Oshiki, Toshiyuki| Sakaguchi, Masakiyo|
Abstract An increasing accumulation of microplastics and further degraded nanoplastics in our environment is suspected to have harmful effects on humans and animals. To clarify this problem, we tested the cytotoxicity of two types of plastic wrap on human cultured liver cells and mouse primary cultured liver cells. Alcohol extracts from plastic wrap, i.e., polyvinylidene chloride (PVDC), showed cytotoxic effects on the cells. Alcohol extracts of polyethylene (PE) wrap were not toxic. The commercially available PVDC wrap consists of vinylidene chloride, epoxidized soybean oil, epoxidized linseed oil as a stiffener and stabilizer; we sought to identify which component(s) are toxic. The epoxidized soybean oil and epoxidized linseed oil exerted strong cytotoxicity, but the plastic raw material itself, vinylidene chloride, did not. Our findings indicate that plastic wraps should be used with caution in order to prevent health risks.
Keywords plastic wrap plasticizer, cytotoxicity, liver cells in vitro
Amo Type Original Article
Published Date 2020-08
Publication Title Acta Medica Okayama
Volume volume74
Issue issue4
Publisher Okayama University Medical School
Start Page 327
End Page 334
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2020 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 32843764
Web of Science KeyUT 000562508700008
NAID 120006880210
reference Parker L: We Made plastic. We depend on it. Now Weʼre drowning in it. National Geographic (2018) 233: 40-87.| Tanaka K and Takada H: Microplastic fragments and microbeads in digestive tracts of planktivorous fish from urban coastal waters. Sci Rep (2016) 6: 34351.| Jeong CB, Kang HM, Lee MC, Kim DH, Han J, Hwang DS, Souissi S, Lee SJ, Shin KH, Park HG and Lee JS: Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana. Sci Rep (2017) 7: 41323.| Lithner D, Nordensvan I and Dave G: Comparative acute toxicity of leachates from plastic products made of polypropylene, olyethylene, PVC, acrylonitrile-butadiene-styrene, and epoxy to Daphnia magna. Environ Sci Pollut Res Int (2012) 19: 1763-1772.| Oehlmann J, Schulte-Oehlmann U, Kloas W, Jagnytsch O, Lutz I, Kusk KO, Wollenberger L, Santos EM, Paull GC, Van Look KJ and Tyler CR: A critical analysis of the biological impacts of plasticizers on wildlife. Philos Trans R Soc Lond B Biol Sci (2009) 364 (1526): 2047-2062.| Doi I, Namba M and Sato J: Establishment and some biological characteristics of human hepatoma cell lines. Gann (1975) 66: 385-392.| Maron DM and Ames BN: Revised methods for the Salmonella mutagenicity test. Mutat Res (1983) 113: 173-215.| Yamada M, Matsui K, Sofuni T and Nohmi T: New tester strains of Salmonella typhimurium lacking O6-methylguanine DNA methyltransferases and highly sensitive to mutagenic alkylating agents. Mutat Res (1997) 381: 15-24.| Blackshear PE, Pandiri AR, Nagai H, Bhusari S, Hong HH, Ton TV, Clayton NP, Wyde M, Shochley KR, Peddada SD, Gerrish KE, Sills RC and Hoenerhoff MJ: Gene expression of mesothelioma in vinylidene chloride-exposed F344/N rats reveal immune dysfunction, tissue damage, and inflammation pathways. Toxicol Pathol (2015) 43 (2): 171-185.| Hayes S, Pandiri AR, Ton TV, Hong HH, Clayton NP, Shockley KR, Peddada SD, Gerrish K, Wyde M, Sills RC and Hoenerhoff MJ: Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice are Characterized by Oxidative Stress and TP53 Pathway Dysregulation. Toxicol Pathol (2016) 44: 71-87.|
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Author Gao, Shangze| Wake, Hidenori| Sakaguchi, Masakiyo| Wang, Dengli| Takahashi, Youhei| Teshigawara, Kiyoshi| Zhong, Hui| Mori, Shuji| Liu, Keyue| Takahashi, Hideo| Nishibori, Masahiro|
Published Date 2020-06-26
Publication Title iScience
Volume volume23
Issue issue6
Publisher Cell Press
Start Page 101180
ISSN 2589-0042
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 32498020
DOI 10.1016/j.isci.2020.101180
Web of Science KeyUT 000548236600006
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Author Tomonobu, Nahoko| Kinoshita, Rie| Sakaguchi, Masakiyo|
Published Date 2020-04-30
Publication Title Translational Oncology
Volume volume13
Issue issue4
Publisher Elsevier
Start Page 100753
ISSN 19365233
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors. Published by Elsevier B.V.
File Version publisher
PubMed ID 32193075
DOI 10.1016/j.tranon.2020.100753
Related Url isVersionOf https://doi.org/10.1016/j.tranon.2020.100753
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Author Tomonobu, Nahoko| Komalasari, Ni Luh Gede Yoni| Sumardika, I Wayan| Jiang, Fan| Chen, Youyi| Yamamoto, Ken-ichi| Kinoshita, Rie| Murata, Hitoshi| Inoue, Yusuke| Sakaguchi, Masakiyo|
Keywords Xylitol Cancer Glutathione ER stress Chemotherapy
Published Date 2020-06-01
Publication Title Chemico-Biological Interactions
Volume volume324
Publisher Elsevier
Start Page 109085
ISSN 0009-2797
NCID AA0060252X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Authors.
File Version publisher
PubMed ID 32275922
DOI 10.1016/j.cbi.2020.109085
Web of Science KeyUT 000531490600009
Related Url isVersionOf https://doi.org/10.1016/j.cbi.2020.109085
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Author Ueki, Yushi| Saito, Ken| Iioka, Hidekazu| Sakamoto, Izumi| Kanda, Yasuhiro| Sakaguchi, Masakiyo| Horii, Arata| Kondo, Eisaku|
Keywords Cancer Molecular Biology
Published Date 2020-01-18
Publication Title iScience
Volume volume23
Issue issue2
Publisher Cell Press
Start Page 100850
ISSN 25890042
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2020 The Author(s).
File Version publisher
PubMed ID 32058962
DOI 10.1016/j.isci.2020.100850
Web of Science KeyUT 000518637100047
Related Url isVersionOf https://doi.org/10.1016/j.isci.2020.100850
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Author Saito, Ken| Iioka, Hidekazu| Maruyama, Satoshi| Sumardika, I. Wayan| Sakaguchi, Masakiyo| Kondo, Eisaku|
Published Date 2019-12-31
Publication Title Neoplasia
Volume volume21
Issue issue12
Publisher Elsevier
Start Page 1121
End Page 1132
ISSN 14765586
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors. Published by Elsevier Inc. on behalf of Neoplasia Press, Inc.
File Version publisher
PubMed ID 31759250
DOI 10.1016/j.neo.2019.09.003
Web of Science KeyUT 000500825600001
Related Url isVersionOf https://doi.org/10.1016/j.neo.2019.09.003
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Author Tomonobu, Nahoko| Kinoshita, Rie| Sumardika, I. Wayan| Chen, Youyi| Inoue, Yusuke| Yamauchi, Akira| Yamamoto, Ken-ichi| Murata, Hitoshi| Sakaguchi, Masakiyo|
Keywords Melanocytes Melanoma Metastasis Primary culture
Published Date 2019-07
Publication Title Biochemistry and Biophysics Reports
Volume volume18
Publisher Elsevier
Start Page 100619
ISSN 24055808
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 30899801
DOI 10.1016/j.bbrep.2019.100619
Related Url isVersionOf https://doi.org/10.1016/j.bbrep.2019.100619
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Author Chen, Youyi| Sumardika, I Wayan| Tomonobu, Nahoko| Kinoshita, Rie| Inoue, Yusuke| Iioka, Hidekazu| Mitsui, Yosuke| Saito, Ken| Ruma, I Made Winarsa| Sato, Hiroki| Yamauchi, Akira| Murata, Hitoshi| Yamamoto, Ken-ichi| Tomida, Shuta| Shien, Kazuhiko| Yamamoto, Hiromasa| Soh, Junichi| Futami, Junichiro| Kubo, Miyoko| Putranto, Endy Widya| Murakami, Takashi| Liu, Ming| Hibino, Toshihiko| Nishibori, Masahiro| Kondo, Eisaku| Toyooka, Shinichi| Sakaguchi, Masakiyo|
Published Date 2019-07
Publication Title Neoplasia
Volume volume21
Issue issue7
Start Page 627
End Page 640
ISSN 1522-8002
NCID AA11470191
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © 2019 The Authors.
File Version publisher
PubMed ID 31100639
DOI 10.1016/j.neo.2019.04.006
Web of Science KeyUT 000472189700001
Related Url isVersionOf https://doi.org/10.1016/j.neo.2019.04.006
Author Putranto, Endy Widya| Murata, Hitoshi| Yamamoto, Ken-Ichi| Kataoka, Ken| Yamada, Hidenori| Futami, Jun-Ichiro| Sakaguchi, Masakiyo| Huh, Nam-Ho|
Published Date 2013-10
Publication Title International Journal of Molecular Medicine
Volume volume32
Issue issue4
Content Type Journal Article
JaLCDOI 10.18926/AMO/52140
FullText URL 68_1_23.pdf
Author Ueno, Tsuyoshi| Toyooka, Shinichi| Fukazawa, Takuya| Kubo, Takafumi| Soh, Junichi| Asano, Hiroaki| Muraoka, Takayuki| Tanaka, Norimitsu| Maki, Yuho| Shien, Kazuhiko| Furukawa, Masashi| Sakaguchi, Masakiyo| Yamamoto, Hiromasa| Tsukuda, Kazunori| Miyoshi, Shinichiro|
Abstract The microRNA-34s (miR-34s) have p53 response elements in their 5ʼ-flanking regions and demonstrate tumor-suppressive functions. In malignant pleural mesothelioma (MPM), we previously reported that expression of miR-34b and miR-34c (miR-34b/c) was frequently downregulated by methylation in MPM cell lines and primary tumors. The forced overexpression of miR-34b/c showed significant antitumor effects with the induction of apoptosis in MPM cells. In this study, we examined the in vivo antitumor effects of miR-34b/c using adenovirus vector on MPM. We subcutaneously transplanted NCI-H290, a human MPM cell line, into BALB/C mice and injected adenovirus vector expressing miR-34b/c, luciferase driven by the cytomegalovirus promoter (Ad-miR-34b/c or Ad-Luc), or PBS control into tumors over 5mm in diameter. A statistically significant growth inhibition of the tumor volume was observed in the Ad-miR-34b/c group from day 6 onward compared to the Ad-Luc group. The inhibition rate of Ad-miR-34b/c, compared to the tumor volume treated with Ad-Luc, was 58.6% on day 10 and 54.7% on day13. Our results indicate that adenovirus-mediated miR-34b/c gene therapy could be useful for the clinical treatment of MPM.
Keywords mesothelioma microRNA microRNA-34b/c p53
Amo Type Original Article
Published Date 2014-02
Publication Title Acta Medica Okayama
Volume volume68
Issue issue1
Publisher Okayama University Medical School
Start Page 23
End Page 26
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24553485
Web of Science KeyUT 000331592800004
Author Tanimoto, Ryuta| Sakaguchi, Masakiyo| Abarzua, Fernando| Kataoka, Ken| Kurose, Kaoru| Murata, Hitoshi| Nasu, Yasutomo| Kumon, Hiromi| Huh, Nam-Ho|
Published Date 2010-04-01
Publication Title International Journal of Cancer
Volume volume126
Issue issue7
Content Type Journal Article
Author Sakaguchi, Masakiyo| Kataoka, Ken| Abarzua, Fernando| Tanimoto, Ryuta| Watanabe, Masami| Murata, Hitoshi| Than, Swe Swe| Kurose, Kaoru| Kashiwakura, Yuji| Ochiai, Kazuhiko| Nasu, Yasutomo| Kumon, Hiromi| Huh, Nam-ho|
Published Date 2009-05-22
Publication Title The Journal of Biological Chemistry
Volume volume284
Issue issue21
Content Type Journal Article
JaLCDOI 10.18926/AMO/48076
FullText URL 66_1_7.pdf
Author Kawauchi, Keiichiro| Watanabe, Masami| Kaku, Haruki| Huang, Peng| Sasaki, Kasumi| Sakaguchi, Masakiyo| Ochiai, Kazuhiko| Huh, Nam-ho| Nasu, Yasutomo| Kumon, Hiromi|
Abstract The preclinical safety and therapeutic efficacy of adenoviral vectors that express the REIC/Dkk-3 tumor suppressor gene (Ad-REIC) was examined for use in prostate cancer gene therapy. The Ad-human (h) and mouse (m) REIC were previously demonstrated to induce strong anti-cancer effects in vitro and in vivo, and we herein report the results of two in vivo studies. First, intra-tumor Ad-hREIC administration was examined for toxicity and therapeutic effects in a subcutaneous tumor model using the PC3 prostate cancer cell line. Second, intra-prostatic Ad-mREIC administration was tested for toxicity in normal mice. The whole-body and spleen weights, hematological and serum chemistry parameters, and histological evaluation of tissues from throughout the body were analyzed. Both experiments indicated that there was no significant difference in the examined parameters between the Ad-REIC-treated group and the control (PBS- or Ad-LacZ-treated) group. In the in vitro analysis using PC3 cells, a significant apoptotic effect was observed after Ad-hREIC treatment. Confirming this observation, the robust anti-tumor efficacy of Ad-hREIC was demonstrated in the in vivo subcutaneous prostate cancer model. Based on the results of these preclinical experiments, we consider the adenovirus-mediated REIC/Dkk-3 in situ gene therapy to be safe and useful for the clinical treatment of prostate cancer.
Keywords REIC Dickkopf-3 gene therapy prostate cancer preclinical study
Amo Type Original Article
Published Date 2012-02
Publication Title Acta Medica Okayama
Volume volume66
Issue issue1
Publisher Okayama University Medical School
Start Page 7
End Page 16
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 22358134
Web of Science KeyUT 000300800700002
Author Ochiai, Kazuhiko| Watanabe, Masami| Ueki, Hideo| Huang, Peng| Fujii, Yasuyuki| Nasu, Yasutomo| Noguchi, Hirofumi| Hirata, Takeshi| Sakaguchi, Masakiyo| Huh, Nam-ho| Kashiwakura, Yuji| Kaku, Haruki| Kumon, Hiromi|
Published Date 2011-08-26
Publication Title Biochemical and Biophysical Research Communications
Volume volume412
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/31719
FullText URL fulltext.pdf
Author Kondo, Asami| Sakaguchi, Masakiyo| Makino, Eiichi| Namba, Masayoshi| Okada, Shigeru| Huh, Nam-ho|
Abstract <p>Using 2-dimensional gel electrophoresis, we previously demonstrated that the S100C protein remarkably decreased after immortalization of normal human fibroblasts, and that this protein caused growth inhibition of human tumor cells when forcibly expressed in these cells, suggesting that S100C plays a significant role in tumor suppression. The present study was carried out to determine what type of human tissues express S100C protein, and, subsequently, whether the S100C content in these tissues changes after normal cells have been transformed into cancer cells. We found that ductal cells in various tissues were positively stained with the S100C protein. In comparison, epithelial cells in digestive organs such as the stomach, small intestine, and colon were not stained as strongly. When 14 pairs of human normal and cancerous tissues were stained with the antibody, decreases in the staining levels of S100C were observed in 6 kinds of cancerous tissues--from the bronchus, mammary duct, renal tubule, prostate, uterus, and testis--in comparison with staining in their normal counterparts. These results suggest that S100C is a new tumor marker protein, the expression of which significantly decreases after malignant transformation of human tissues.</p>
Keywords S100C-antibody human tissues immunostaining
Amo Type Article
Published Date 2002-02
Publication Title Acta Medica Okayama
Volume volume56
Issue issue1
Publisher Okayama University Medical School
Start Page 31
End Page 34
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11873942
Web of Science KeyUT 000174031300006