Okamoto, Kuniaki - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

MMP-3 cleavage of Lamin A induces pro-migratory nuclear deformity, nucleophagy, and their autophagic secretion with extracellular vesicles in metastatic cancer

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Author	Eguchi, Takanori\| Taha, Eman A.\| Nakano, Keisuke\| Tiwari, Vikas\| Takebe, Katsuki\| Inoue, Tomohiro\| Xing, Lizi\| Sogawa, Chiharu\| Okamoto, Kuniaki\| Calderwood, Stuart K.\|
Keywords	Lamin A (LMNA) Matrix metalloprotease (MMP) Proteolysis Extracellular vesicle (EV) Exosome Autophagy Amphisome Proteome Nuclear deformity Migration Metastatic cancer Head and neck squamous cell carcinoma Colorectal cancer
Published Date	2026-01-15
Publication Title	Cell Communication and Signaling
Volume	volume24
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	146
ISSN	1478-811X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2026.
File Version	publisher
PubMed ID	41540428
DOI	10.1186/s12964-025-02549-6
Web of Science KeyUT	001702916400001
Related Url	isVersionOf https://doi.org/10.1186/s12964-025-02549-6

Dennd2c Negatively Controls Multinucleation and Differentiation in Osteoclasts by Regulating Actin Polymerization and Protrusion Formation

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Author	Koyanagi, Yu\| Sakai, Eiko\| Yamaguchi, Yu\| Farhana, Fatima\| Taira, Yohsuke\| Okamoto, Kuniaki\| Murata, Hiroshi\| Tsukuba, Takayuki\|
Keywords	osteoclast actin polymerization protrusion formation Dennd2c
Published Date	2024-10-25
Publication Title	International Journal of Molecular Sciences
Volume	volume25
Issue	issue21
Publisher	MDPI AG
Start Page	11479
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by the authors.
File Version	publisher
PubMed ID	39519032
DOI	10.3390/ijms252111479
Web of Science KeyUT	001351409700001
Related Url	isVersionOf https://doi.org/10.3390/ijms252111479

New Catalytic Residues and Catalytic Mechanism of the RNase T1 Family

FullText URL	fulltext.pdf suppl.pdf
Author	Takebe, Katsuki\| Suzuki, Mamoru\| Hara, Yumiko\| Katsutani, Takuya\| Motoyoshi, Naomi\| Itagaki, Tadashi\| Miyakawa, Shuhei\| Okamoto, Kuniaki\| Fukuzawa, Kaori\| Kobayashi, Hiroko\|
Keywords	RNase crystal structure fragment molecular orbital method interfragment interaction energy antitumor activity RNase activity
Published Date	2024-09-20
Publication Title	ACS Bio & Med Chem Au
Volume	volume4
Issue	issue5
Publisher	American Chemical Society (ACS)
Start Page	257
End Page	267
ISSN	2694-2437
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Authors.
File Version	publisher
PubMed ID	39431265
DOI	10.1021/acsbiomedchemau.4c00046
Web of Science KeyUT	001318689400001
Related Url	isVersionOf https://doi.org/10.1021/acsbiomedchemau.4c00046

Resident stroma-secreted chemokine CCL2 governs myeloid-derived suppressor cells in the tumor microenvironment

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Author	Oo, May Wathone\| Kawai, Hotaka\| Takabatake, Kiyofumi\| Tomida, Shuta\| Eguchi, Takanori\| Ono, Kisho\| Shan, Qiusheng\| Ohara, Toshiaki\| Yoshida, Saori\| Omori, Haruka\| Sukegawa, Shintaro\| Nakano, Keisuke\| Okamoto, Kuniaki\| Sasaki, Akira\| Nagatsuka, Hitoshi\|
Published Date	2022-01-11
Publication Title	JCI Insight
Volume	volume7
Issue	issue1
Publisher	American Society for Clinical Investigation
Start Page	e148960
ISSN	2379-3708
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022, Oo et al.
File Version	publisher
PubMed ID	34874922
DOI	10.1172/jci.insight.148960
Web of Science KeyUT	000743257400001
Related Url	isVersionOf https://doi.org/10.1172/jci.insight.148960

Exosome-Based Molecular Transfer Activity of Macrophage-Like Cells Involves Viability of Oral Carcinoma Cells: Size Exclusion Chromatography and Concentration Filter Method

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Author	Lu, Yanyin\| Eguchi, Takanori\| Sogawa, Chiharu\| Taha, Eman A.\| Tran, Manh Tien\| Nara, Toshiki\| Wei, Penggong\| Fukuoka, Shiro\| Miyawaki, Takuya\| Okamoto, Kuniaki\|
Keywords	macrophage exosomes extracellular vesicles molecular transfer size exclusion chromatography and concentration filter (SEC-CF) method heat shock proteins oral carcinoma
Published Date	2021-05-27
Publication Title	Cells
Volume	volume10
Issue	issue6
Publisher	MDPI
Start Page	1328
ISSN	2073-4409
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 by the authors.
File Version	publisher
PubMed ID	34071980
DOI	10.3390/cells10061328
Web of Science KeyUT	000665278700001
Related Url	isVersionOf https://doi.org/10.3390/cells10061328

Gel-Free 3D Tumoroids with Stem Cell Properties Modeling Drug Resistance to Cisplatin and Imatinib in Metastatic Colorectal Cancer

FullText URL	2021 02 sogawa cells tumoroid drug resist.pdf
Author	Sogawa, Chiharu\| Eguchi, Takanori\| Namba, Yuri\| Okusha, Yuka\| Aoyama, Eriko\| Ohyama, Kazumi\| Okamoto, Kuniaki\|
Keywords	gel-free 3D culture tumoroid cisplatin resistance imatinib (gleevec) tyrosine kinase inhibitor (TKI) spheroid metastatic colorectal cancer (mCRC) stem cells
Published Date	2021-02-06
Publication Title	Cells
Volume	volume10
Issue	issue2
Publisher	MDPI
Start Page	344
ISSN	2073-4409
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 Authors.
File Version	publisher
DOI	10.3390/cells10020344
Related Url	isVersionOf https://doi.org/10.3390/cells10020344

Triple knockdown of CDC37, HSP90‐alpha and HSP90‐beta diminishes extracellular vesicles‐driven malignancy events and macrophage M2 polarization in oral cancer

FullText URL	2020 06 Ono K triple kd JEV.pdf
Author	Ono, Kisho\| Sogawa, Chiharu\| Kawai, Hotaka\| Manh Tien Tran\| Taha, Eman A.\| Lu, Yanyin\| May Wathone Oo\| Okusha, Yuka\| Okamura, Hirohiko\| Ibaragi, Soichiro\| Takigawa, Masaharu\| Kozaki, Ken-Ichi\| Nagatsuka, Hitoshi\| Sasaki, Akira\| Okamoto, Kuniaki\| Calderwood, Stuart K.\| Eguchi, Takanori\|
Keywords	Extracellular vesicles epithelial‐mesenchymal transition tumour‐associated macrophage CDC37 HSP90 tetraspanin oral cancer
Published Date	2020-05-31
Publication Title	Journal of Extracellular Vesicles
Volume	volume9
Issue	issue1
Publisher	Taylor & Francis
Start Page	1769373
ISSN	2001-3078
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Author(s).
File Version	publisher
PubMed ID	33144925
DOI	10.1080/20013078.2020.1769373
Related Url	isVersionOf https://doi.org/10.1080/20013078.2020.1769373

The Inhibitory Role of Rab11b in Osteoclastogenesis through Triggering Lysosome-Induced Degradation of c-Fms and RANK Surface Receptors

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Author	Tran, Manh Tien\| Okusha, Yuka\| Feng, Yunxia\| Morimatsu, Masatoshi\| Wei, Penggong\| Sogawa, Chiharu\| Eguchi, Takanori\| Kadowaki, Tomoko\| Sakai, Eiko\| Okamura, Hirohiko\| Naruse, Keiji\| Tsukuba, Takayuki\| Okamoto, Kuniaki\|
Keywords	Rab11b c-Fms RANK NFATc-1 osteoclasts vesicular transport
Published Date	2020-12-08
Publication Title	International Journal of Molecular Sciences
Volume	volume21
Issue	issue24
Publisher	MDPI
Start Page	9352
ISSN	1422-0067
NCID	AA12038549
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	33302495
DOI	10.3390/ijms21249352
Web of Science KeyUT	000603505100001
Related Url	isVersionOf https://doi.org/10.3390/ijms21249352

Rab11A Functions as a Negative Regulator of Osteoclastogenesis through Dictating Lysosome-Induced Proteolysis of c-fms and RANK Surface Receptors

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Author	Okusha, Yuka\| Tran, Manh Tien\| Itagaki, Mami\| Sogawa, Chiharu\| Eguchi, Takanori\| Okui, Tatsuo\| Kadowaki, Tomoko\| Sakai, Eiko\| Tsukuba, Takayuki\| Okamoto, Kuniaki\|
Keywords	Rab11A c-fms RANK NFATc-1 osteoclast vesicular transport
Published Date	2020-10-31
Publication Title	Cells
Volume	volume9
Issue	issue11
Publisher	MDPI
Start Page	2384
ISSN	2073-4409
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	33142674
DOI	10.3390/cells9112384
Web of Science KeyUT	000593550100001
Related Url	isVersionOf https://doi.org/10.3390/cells9112384

Knockout of MMP3 Weakens Solid Tumor Organoids and Cancer Extracellular Vesicles

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Author	Taha, Eman A.\| Sogawa, Chiharu\| Okusha, Yuka\| Kawai, Hotaka\| Oo, May Wathone\| Elseoudi, Abdellatif\| Lu, Yanyin\| Nagatsuka, Hitoshi\| Kubota, Satoshi\| Satoh, Ayano\| Okamoto, Kuniaki\| Eguchi, Takanori\|
Keywords	matrix metalloproteinase 3 (MMP3) extracellular vesicles (EVs) tumoroid tumor organoid tumorigenesis three-dimensional (3D) culture system
Published Date	2020-05-16
Publication Title	Cancers
Volume	volume12
Issue	issue5
Publisher	MDPI
Start Page	1260
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	32429403
DOI	10.3390/cancers12051260
Web of Science KeyUT	000539246000201
Related Url	isVersionOf https://doi.org/10.3390/cancers12051260

Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer

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Author	Okusha, Yuka\| Eguchi, Takanori\| Tran, Manh T.\| Sogawa, Chiharu\| Yoshida, Kaya\| Itagaki, Mami\| Taha, Eman A.\| Ono, Kisho\| Aoyama, Eriko\| Okamura, Hirohiko\| Kozaki, Ken-Ichi\| Calderwood, Stuart K.\| Takigawa, Masaharu\| Okamoto, Kuniaki\|
Keywords	matrix metalloproteinase moonlighting metalloproteinase (MMP) protein moonlighting transcription factor extracellular vesicles oncosome genome editing CRISPR cellular communication network factor CCN2/CTGF
Published Date	2020-04-04
Publication Title	Cancers
Volume	volume12
Issue	issue4
Publisher	MDPI
Start Page	881
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	32260433
DOI	10.3390/cancers12040881
Web of Science KeyUT	000535587400110
Related Url	isVersionOf https://doi.org/10.3390/cancers12040881