| JaLCDOI | 10.18926/15518 |
|---|---|
| Title Alternative | Clinical significance of spa therapy in patients with steroid-dependent intractable asthma |
| FullText URL | 065_119_127.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| |
| Abstract | 気管支喘息のなかでも,副腎皮質ホルモン依存性の喘息は,もっとも重症難治性であり,薬物療法のみでコントロールすることは極めて困難である｡著者らの現在までの成績では,このようなステロイド依存性重症難治性喘息に対して,温泉療法は有効であった｡このことは,喘息の治療,とりわけ重症難治例の治療には温泉療法が必要不可欠であることを示している｡今回は,その臨床的有用性および機序について,若干の考察を加えた｡1.臨床病型では,Ib型やII型に重症難治症例が多く,温泉療法はこれらの病型に対して有効であった｡2.年齢別検討では,発症年齢では30才以上,また現年齢では40才以上の症例に対して温泉療法は有効であった｡3.温泉療法による換気機能の改善では,小ないし細気管支領域の閉塞の改善がより高度であった｡4.温泉療法により,気道過敏性が低下することが観察された｡5.温泉療法により,高度に低下した副腎皮質機能の改善が見られた｡5.ヨードゾル吸入,鉱泥湿布療法,温泉プール水泳ないし歩行訓練などが,喘息の治療に適した温泉療法と判断された。 |
| Keywords | 重症難治性喘息 (intractable asthma) 換気機能 (ventilatory function) ヨードゾル吸入 (inhalation of iodine salt solution) 鉱泥湿布療法 (fango therapy) 温泉プール水泳訓練 (swimming training in a hot spring pool) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1994-09 |
| Volume | volume65 |
| Start Page | 119 |
| End Page | 127 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307310 |
| JaLCDOI | 10.18926/15345 |
|---|---|
| Title Alternative | 気管支喘息の発症における加齢の影響について |
| FullText URL | 063_142_147.pdf |
| Author | Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Tanizaki, Yoshiro| |
| Abstract | Skin tests, serum total IgE levels, specific IgE antibodies against each allergen, bronchial reactions provoked by allergens and histamine release from basophils are well known as prameters of immediate allergic reactions. The incidence of positive immediate skin reaction to allergens such as house dust, ragweed, Aspergillus Alternaria, Cladosporium and Broncasma decreased with aging. On the other hand, the incidence of positive skin reaction to Candida albicans was higher in cases between the age of 41 and 50 and cases over the age of 61 compared to that in the other groups classified by age. Serum IgE levels was highest in cases aged between 0 and 30. The levels of serum IgE decreased with aging. The incidence of positive RAST scores (more than 2+) and positive bronchial reaction to house dust were highest in cases between 0 and 30, and decreased with aging. However, the positive ratio of these tests against C. albicans were highest in cases between 41 and 50. The degree of histamine release from basophils of asthmatics induced by anti-IgE was consistently high without any correlation to aging when their serum IgE levels were more than 501 IU/ml. In the cases with serum IgE levels of less than 300 IU/ml, basophil reactivity to anti-IgE decreasd with aging. Basophil reactivity to house dust was generally dependent on the levels of specific IgE antibodies against the allergen. Although basophil reactivity to C. albicans was also high in cases with positive RAST scores, some cases with a RAST score of 0+ or 1+ showed high or moderate basophil reactivity. Moderate or high reactivity of basophils was frequently observed in cases between 41 and 50 and cases over age 61. |
| Keywords | Skin test (皮内反応) IgE Provocation test (吸入誘発試験) Basophil reactivity (好塩基球の反応性) Aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 142 |
| End Page | 147 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307130 |
| JaLCDOI | 10.18926/15343 |
|---|---|
| Title Alternative | 抗原および抗ヒトIgEに対する抗塩基球の反応性. 3.Ca2(+)の細胞内流入およびヒスタミン遊離 |
| FullText URL | 063_134_141.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro| |
| Abstract | The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE. |
| Keywords | Ca(2+) influx (Ca2+流入) histamine release (ヒスタミン遊離) house dust (ハウスダスト) Candida albicans (カンジダ) anti-lgE (抗ヒトIgE) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 134 |
| End Page | 141 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307872 |
| JaLCDOI | 10.18926/15338 |
|---|---|
| Title Alternative | Immunotherapy in house dust mite sensitive asthma |
| FullText URL | 063_117_122.pdf |
| Author | Okazaki, Morihiro| Kitani, Hikaru| Mifune, Takasi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honnke, Naoko| Kusaura, Yasuhiro| Tanizaki, Yoshiro| |
| Abstract | ダニ喘息はアトピー型喘息の典型であるが,これに対する根本療法としてアレルゲンであるハウスダストを皮下注射する免疫療法が臨床でおこなわれている。70-80%の有効性が報告されているが,その作用機序はいまだ不明である｡この稿においては特異的IgE抗体,特異的IgG抗体,特異的lgG4抗体,抗イディオタイプ抗体,肥満細胞の反応性,リンパ球の役割について総説する｡また新たな試みとしてのallergen antibody complexを使った免疫療法,ペプタイドを使用する治療の可能性についても言及する｡ |
| Keywords | ダニ喘息 (House dust mite sensitive bronchial asthma) 免疫療法 (lmmunotherapy) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 117 |
| End Page | 122 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307745 |
| JaLCDOI | 10.18926/15337 |
|---|---|
| Title Alternative | Pathogenic significance of IgG and IgG(4) antibodies against Candida albicans in bronchial asthma |
| FullText URL | 064_116_124.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| |
| Abstract | カレジダ特異的IgG及びIgG(4)抗体が,気管支喘息の発症病態に関与しているかどうかについて検討を加えた。カンジダ特異的IgGおよびIgG(4)抗体は, 0-30才の年齢層の症例ではアトピー性素因の強い症例で,また,31-60才の年齢層の症例ではストロイド依存性重症難治性喘息症例で,さらに61才以上の高年令の症例で,その産生亢進が観察される｡これらの症例におけるIgG及びIgG(4)抗体産生は,0-30才の年齢ではアトピーとの関連で,また31-60才の年齢では副腎皮質ホルモンの長期投与と関連して,さらに61才以上の症例では加齢と関連して,細胞性免疫能が低下し,そのためカンジダの発育が促進され,その結果として,IgG及びIgG(4)抗体の産生亢進が見られることが明らかにされている｡すなわち,気管支喘息におけるカンジダに対するIgG系抗体の産生亢進は,cell-mediated immunityの低下と言う共通の基盤を有しており,病因的意義とは必ずしも関連していないことを述べた。 |
| Keywords | カンジダ (Candida) lgG抗体 (IgG antibodies) IgG(4)抗体 (IgG(4) antibodies) アトピー (Atopy) 気管支喘息 (Bronchial asthma) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 116 |
| End Page | 124 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307381 |
| JaLCDOI | 10.18926/15332 |
|---|---|
| Title Alternative | 気管支肺胞洗浄液中リンパ球増多と患者年齢およびIgE系アレルギー反応との関連について |
| FullText URL | 064_097_104.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro| |
| Abstract | The proportion and number of lymphocytes in the airways were analyzed in 15 patients with a high proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid (more than 30%) and in 17 patients with less than 20% of BAL lymphocytes. 1. Both atopic and nonatopic asthma patients with a high proportion of BAL lymphocytes were aged more than 50 years. In contrast, the age of patients with less than 20% of BAL lymphocytes ranged widely, from 29 to 63 years, in the two asthma types. 2. Age at onset of the disease, serum IgE levels, and ventilatory function test were not related to the proportion of BAL lymphocytes. 3. In patients with a high proportion of BAL lymphocytes, the mean proportion of these cells was 47.3% in atopic patients and 36.4% in non-atopic patients, i. e., there was no significant difference between the two asthma types. The absolute number of BAL lymphocytes in these patients was significantly higher in atopic (5.62×10(6)) than in nonatopic asthma (0.77×10(6)) (p<0.01). These findings show that an increased number of lymphocytes in the airways is clearly related to patient age and IgE-mediated allergic reaction. |
| Keywords | BAL lymphocytes patient age IgE-mediated allergic reaction bronchial asthma |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 97 |
| End Page | 104 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307637 |
| JaLCDOI | 10.18926/15327 |
|---|---|
| Title Alternative | Inhibitory effect of furosemide on histamine release from human basophils |
| FullText URL | 063_095_098.pdf |
| Author | Kitani, Hikaru| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro| |
| Abstract | furosemideは利尿剤として知られているが,吸入することにより気道収縮に対して抑制的に作用することが近年報告されている｡その抑制作用の機序を明らかにする目的で,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果を検討した｡健常人4例,アトピー型気管支喘息患者8例を対象として全血法で抗ヒトIgE刺激によるヒスタミン遊離を観察した｡なお,furosemideの最終濃度は0,1,10,100μg/mlに調整して添加実験を行った｡健常人,気管支喘息いずれにおいても,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果はみられなかった｡ |
| Keywords | 気管支喘息 (Bronchial asthma) フロセミド (Furosemide) ヒスタミン遊離 (Histamine release) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 95 |
| End Page | 98 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307119 |
| JaLCDOI | 10.18926/15326 |
|---|---|
| Title Alternative | Clinical evaluation of an endoscopic image filing system, Olympus SDF-3 |
| FullText URL | 063_074_078.pdf |
| Author | Ochi, Koji| Miyake, Hirofumi| Matsumoto, Shuji| Seno, Toshinobu| Tanaka, Juntaro| Harada, Hideo| Mitsunobu, Fumihiro| Tanizaki, Yosiro| |
| Abstract | 光ディスクとパーソナルコンピュータを組み合わせた内視鏡画像ファイリングシステムは電子内視鏡の画像の保存･管理,検索･再生などに威力を発揮する｡今回,われわれはオリンパス社製内視鏡ファイリングシステムSDF-3を使用する機会を得たので,その有用性や問題点の検討を行った｡有用性としては,①内視鏡画像を検査終了後直ちに再生し,再検討できる,②多数の項目についての検索や統計処理が可能である,③限られたスペース内で大量の画像データの一括保存･管理が可能であるなどが挙げられる｡一方,問題点としては,①内視鏡再生画像は画質が劣化する,②検索機能を十分に活用するにはかなり煩雑な人力操作を必要とする,③光ディスクの清掃が必要であるなどがあげられる｡本内視鏡ファイリングシステムに今後必要な改良点やその展望についても合わせて考案を加えた。 |
| Keywords | 画像ファイリングシステム (image filing system) 電子内視鏡 (electronic endoscope) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 74 |
| End Page | 78 |
| ISSN | 0913-3771 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307278 |
| JaLCDOI | 10.18926/15325 |
|---|---|
| Title Alternative | 気管支喘息患者における細胞性免疫,ガンジダ抗原に対する遅延型反応の抑制 |
| FullText URL | 063_069_073.pdf |
| Author | Tanizaki, Yosiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Harada, Hideo| Ochi, Koji| Kimura, Ikuro| |
| Abstract | Delayed cutaneous hypersensitivity towards Candida albicans was examined in 200 patients with bronchial asthma in relation to patient age and the level of total IgE. 1. Delayed skin reactivity towards C.albicans was depressed in the patients between the ages of 10 and 20 and in those over the age of 61. A significant difference was present in delayed skin reactivity between the groups of 10-20 and 41-50 years old. 2. The frequency of the patients with positive delayed skin reactivity towards C.albicans was the highest in those with low levels of total IgE (0 -100 IU/ml) and the low est in those with high levels of total IgE (over than 1001 IU/ml). The results suggest that cell-mediated immunity towards C.albicans is depressed re lating to atopics in the patients between 10 and 20 and to aging in the patients over 61. |
| Keywords | cell-mediated immunity (細胞性免疫) bronchial asthma (気管支喘息) atopics (アトピー) aging (加齢) カンジダ |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 69 |
| End Page | 73 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307949 |
| JaLCDOI | 10.18926/15324 |
|---|---|
| Title Alternative | 臨床所見および検査成績からのスコアーによる喘息分類の特徴 |
| FullText URL | 063_063_068.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Takatori, Akimasa| Okuda, Hiroyuki| Kimura, Ikuro| |
| Abstract | Twenty six patients with bronchial asthma was classified by clinical symptoms and singns (clinical diagnosis), and the classification by clinical diagnosis was compared with the classification by a score calculated from clinical findings and examinations (score diagnosis). 1. Of 12 subjects with type Ia classified by clinical diagnosis, 8 cases with 0 to 49 ml/day of expectoration were evaluated as type Ia by score diagnosis. While four type Ia cases with 50 to 99ml/day of expectoration were calssified as type Ib by score diagnosis. The increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF) of these four cases was similar to the incidence in type Ib cases with hypersecretion. 2. All of 6 subjects with type Ib by clinical diagnosis were estimated as type Ib by score diagnosis. 3. Of 8 cases with type II by clinical diagnosis, 7 cases were assessed as type II by score diagnosis. One case with type II by clinical diagnosis and with the score of 10 points was evaluated as questionable type II by score diagnosis. |
| Keywords | asthma classification (喘息分類) bronchoconstriction (気管支攣縮) hypersecretion (過分泌) bronchiolar obstruction (細気管支閉塞) score diagnosis (スコアー診断) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 63 |
| End Page | 68 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307348 |
| JaLCDOI | 10.18926/15322 |
|---|---|
| Title Alternative | 高齢者健常人および気管支喘息患者におけるカンジダ特異的IgGおよびIgG(4)抗体について |
| FullText URL | 063_058_062.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kotoh, Naoki| Tada, Shinya| Kimura, Ikuro| |
| Abstract | Specific IgG and IgG(4) antibodies against Canadida albicans were exmined in 48 healthy and 69 asthmatic subjects to analyze the mechanism causing an increased production of these immunoglobulins. 1. The level of C.albicans-specific IgG and IgG(4) antibodies was higher, not significantly in IgG(4), in asthmatics under 30 years of age, compared with healthy subjects of the same age group. 2. Specific IgG and IgG(4) antibody levels in both healthy and asthmatic subjects showed a tendency to increase with aging, and significant difference was present between cases under 30 years and cases over 70 years of age. 3. Any difference in the production of specific IgG and IgG(4) was not observed in elderly cases older than 60 years between healthy and asthmatic subjects. |
| Keywords | Candida albicans (カンジダ特異的IgG) Specific IgG IgG(4) Bronchial asthma (気管支喘息) Aging (加齢) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 58 |
| End Page | 62 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307284 |
| JaLCDOI | 10.18926/15320 |
|---|---|
| Title Alternative | 気管支喘息における気道の反応性および炎症反応におよぼす加齢の影響について |
| FullText URL | 064_089_096.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Ventilatory function, cellular composition in bronchoalveolar lavage (BAL) fluid and release of chemical mediators from leucocytes were examined in 25 older asthmatics (mean age 66.7 years) and 25 younger asthmatics (mean age 45.1 years) in relation to clinical asthma types. 1. Ventilatory function tests showed that the values of ventilatory parameters such as % MMF, % V(50) and % V(25) were lower in older subjects than in younger subjects, and a significant difference was found in the % V(50) value between the two age groups. Regarding clinical asthma types, the values of % MMF, % V(50), and V(25) were significantly lower in both younger and older subjects with type II. 2. In analysis of cellular composition in BAL fluid, the proportion of BAL lymphocytes was significantly lower in type II older subjects than in younger subjects with the same type. A significantly increased proportion of BAL neutrophils was observed in both younger and older subjects with type II. 3. The release of leukotriene C(4) (LTC(4)) from leucocytes was significantly lower in type II older subjects than in younger subjects with the same type, and LTC(4) release in patients with type II was also significantly lower than that in those with other asthma types in both younger and older subjects. The release of histamine and leukotriene B(4) (LTB(4)) from leucocytes was not significantly different between the two age groups. These results demonstrate that ventilatory function, cellular composition in BAL fluid, and the release of chemical mediators from leucocytes are affected by aging and clinical asthma types. |
| Keywords | Ventilatory function (換気機能) Cellular composition in BAL fluid (気道内細胞成分) chemical mediators (化学伝達物質) aging (加齢) clinical asthma type (臨床病型) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 89 |
| End Page | 96 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307744 |
| JaLCDOI | 10.18926/15319 |
|---|---|
| Title Alternative | Effects of vitamin D and exercise on bone mineral density (BMD) measuured by QCT |
| FullText URL | 064_071_074.pdf |
| Author | Hiramatsu, Junnichi| Kawaraya, Masashi| Yokota, Satoshi| Sugimoto, Keisuke| Mitsunobu, Fumihiro| Mifune, Takashi| Kajimoto, Kazuhiro| Kitani, Hikaru| Tanizaki, Yoshiro| Nakai, Mutsuro| Akiyama, Tsuneo| |
| Abstract | 40才～84才(平均64.1才)の患者38例における骨塩量を,ある期間(1～15カ月,平均8.2カ月)をおいて2回,定量的QCT(quantitative computed tomography)法を用いて測定し,その経時的変化によって,骨粗鬆症に対する治療法の効果判定を試みた｡その結果,(1)全体として骨塩量に有意の増加は認められなかった｡(2)骨強化剤使用例についても骨塩量に有意の増加は認められなかった｡(3)運動療法施行者においても骨塩量に有意の増加は認められなかった｡以上のことから骨粗鬆症の治療においては,約1年弱の経過では著明な反応は得られにくいものと思われた｡ただし,一部の運動療法施行者,骨強化剤使用者において,骨塩量の著明な上昇が認められており,さらに経時的な観察が必要と思われた。 |
| Keywords | 骨粗鬆症 (Osteoprosis) 定量的QCT法 (QCT) 加齢 (Aging) 運動療法 (Exercise) ビタミンD (Vitamin D) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 71 |
| End Page | 74 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307358 |
| JaLCDOI | 10.18926/15318 |
|---|---|
| Title Alternative | 老令者の気管支喘息,各臨床病型における換気機能の特徴 |
| FullText URL | 063_044_049.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Takatori, Akimasa| Okuda, Hiroyuki| Kimura, Ikuro| |
| Abstract | Ventilatory function was examined in 20 elderly patients with bronchial asthma in relation to clinical asthma types, and the results were compared with those of younger asthmatics. 1. Ventilatory parameters such as FEV(1.0%), % PEFR, % MMF, % V(50) and % V(25), which repressent obstructive ventilatory dysfunction, were in general lower in older asthmatics than in the youger cases. 2. The values of % V(50) and % V(25), representing ventilatory dysfunction in small airways, were significantly lower in the older subjects with type Ib and II compared to the younger cases with same types. 3. Markedly decreased values in ventilatory parameters, particularly in % MMF, % V(50) and % V(25) were observed in both older and younger subjects with type II. The results suggest that ventilatory function decreases with aging and the decrease is related to the pathophysiological changes in the airways. |
| Keywords | Ventilatory function (換気機能) small airways (細気管支) clinical asthma types (臨床病型) elderly asthmatics (老年者気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 44 |
| End Page | 49 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307531 |
| JaLCDOI | 10.18926/15317 |
|---|---|
| Title Alternative | Diagonosis of pancreatic cyst using post-ERCP CT examination. |
| FullText URL | 064_065_070.pdf |
| Author | Ochi, Koji| Harada, Hideo| Matsumoto, Shuji| Seno, Tosinobu| Tanaka, Juntaro| Riaz Chowdhury| Mizushima, Takaaki| Sugimoto, Keisuke| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Nakai, Mutsuo| Akiyama, Tsuneo| Hasuoka, Hideaki| |
| Abstract | ERCP直後にCTを撮影するERCP後CTはERCPの際に膵内に注入された造影剤をCTで検出するため,ERCPでは得られない情報が得られる利点がある｡われわれはERCP後CTが診断や治療方針の決定に有用であった膵嚢胞の4例を経験した｡膵嚢胞では主膵管との連絡,嚢胞の部位,性状診断にERCP後CTは有用な検査法であり,文献的考察を含めて報告した｡ |
| Keywords | ERCP (Endoscopic retrograde cholangiopancreatography) CT (Computed tomography) 膵嚢胞 (pancreatic cyst) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 65 |
| End Page | 70 |
| ISSN | 0918-7839 |
| language | Japanese |
| File Version | publisher |
| NAID | 120002307547 |
| JaLCDOI | 10.18926/15316 |
|---|---|
| Title Alternative | 老年者の気管支喘息. アレルギー反応と気道細胞反応 |
| FullText URL | 063_039_043.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Ochi, Koji| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Clinical features of bronchial asthma in the elderly were analyzed by observlng IgE-mediated allerglc reactions evaluated by immediate skin reaction and specific IgE antibodies to allergens, ventilatory function and cellular composition in bronchoalveolar lavage (BAL) fluid. 1. The frequency of positive immediate skin reaction and positive RAST score to allergens was in general low in the elderly patients over age 70. 2. Ventilatory function was widely variegated, and fifteen cases (60%) of the 25 Subjects showed considerably high values of FEV(l.0%), % PEFR, % MMF, % V(50) and % V(25), and the mean value of FEV(1.0%) in these cases was 71.3%. 3. The decreased value of % V(25) was related to BAL neutrophilia in 2 cases, but any correlation was not found between BAL neutrophilia and decreased value of % V(25) in 9 csese of the eleven subjects who had the BAL examination. The results show that in asthma of elderly patients, IgE-mediated allergic reactions are weak, and that a decreased value of % V(25) can be observed without BAL neutrophilia. |
| Keywords | elderly subjects (老年者) lgE-mediated allergic reaction (IgE系反応) ventilatory function (換気機能) BAL neutrophilia (BAL好中球) bronchial asthma (気管支喘息) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 39 |
| End Page | 43 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307727 |
| JaLCDOI | 10.18926/15314 |
|---|---|
| Title Alternative | 気管支肺胞洗浄液中に一過性の好中球増多をきたしたアトピー型喘息 |
| FullText URL | 064_052_059.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Nakagiri, Yoshiyasu| Tada, Shinya| Kimura, Ikuro| |
| Abstract | Clinical course of one asthma patient (64 years old, female), who had an increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid, was observed in relation to the proportion of BAL cells and ventilatory function. The patient had large asthma attacks two times during her clinical course for 15 months observed. 1. An increased proportion of BAL neutrophils and suppression of ventilatory function were found after her first large asthma attacks. The increased proportion of BAL neutrophils continued for more than 5 months. A reduction in the proportion of BAL neutrophils was found 3 months after her second large asthma attack, accompanied by improvement of clinical symptoms and ventilatory function. The numbers of total cells and neutrophils in BAL fluid were also reduced. Transient increase in number of BAL lymphocytes was found 13 months after the first large attack when the number of BAL neutrophils was markedly decreased. The number of BAL eosinophils did not change during her clinical course. |
| Keywords | Bronchial asthma (気管支喘息) transient BAL neutrophilia(一過性BAL液中好中球増多) ventilatory function (換気機能) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 52 |
| End Page | 59 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307805 |
| JaLCDOI | 10.18926/15313 |
|---|---|
| FullText URL | 063_034_038.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Kimura, Ikuro| |
| Abstract | The serum levels of total IgE, IgG and IgG(4) were compared among five age groups of patients with bronchial asthma. 1. The level of serum IgE was significantly higher in the patients before the age of 29 than in those between the ages of 30 and 49 (p < 0.02), between 50 and 59 (p < 0.01) and between 60 and 69 (p < 0.01). The serum IgE level tended to increase in the patients over age 70. 2. The serum level of total IgG was significantly higher in the patients over age 70 compared with the level in the 30-49 (p < 0.05) and the 60-69 year old groups (p < 0.05). 3. The serum IgG(4) level was increased with aging, although no significant difference was found among the five age groups. 4. The IgG(4) level correlated to a certain extent with the level of serum IgE. The results reveal that the levels of total IgE, IgG and IgG(4) are increased in the elderly patients over age 70, and that there is a relationship between serum levels of total IgE and IgG(4). |
| Keywords | Total IgE IgG IgG(4) aging bronchial asthma |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1992-06 |
| Volume | volume63 |
| Start Page | 34 |
| End Page | 38 |
| ISSN | 0913-3771 |
| language | English |
| File Version | publisher |
| NAID | 120002307767 |
| JaLCDOI | 10.18926/15312 |
|---|---|
| Title Alternative | 老年者気管支喘息における気道炎症細胞.喘息重症度と関連した気道細胞反応の特徴 |
| FullText URL | 064_083_088.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Nakagiri, Yoshiyasu| Harada, Hideo| Kimura, Ikuro| |
| Abstract | Cellular composition of bronchoalveolar lavage (BAL) fluid was examined in 11 elderly asthmatics over the age of 70, and the results were compared with those of 11 younger asthmatics under the age of 50. In the subjects with mild asthma, the proportion of BAL cells in the elderly subjects was 86.2% macrophages, 11.0% lymphocytes, 1.9% neutrophils, 0.9% eosinophils and 0.08% basophilic cells. The proportion of neutrophils and eosinophils in the BAL fluid was slightly higher in younger subjects with mild asthma compared with that in elderly subjects, although no significant difference was found between the two groups. In subjects with severe asthma, the proportions of lymphocytes, neutrophils, eosinophils and basophilic cells were more increased in both younger and older patients compared to those with mild asthma, and a significant increase in the number of BAL eosinophils was found in younger subjects with severe asthma compared to those with mild asthma (p < 0.05). However, no significant difference was present in the proportion of BAL cells between younger and older patients with severe asthma. The results reveal that BAL cells are more increased in subjects with suvere asthma than in those with mild asthma in both younger and older subjects, and show the possibility that this increase is more predominant in neutrophils in older subjects and in eosinophils in younger subjects. |
| Keywords | Neutrophils (好中球) Eosinophils (好酸球) Bronchoalveolar lavage (気管支肺胞洗浄) asthma severity (喘息重症度) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 83 |
| End Page | 88 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307736 |
| JaLCDOI | 10.18926/15311 |
|---|---|
| Title Alternative | 抗原および Ca ionophore A23187 刺激時におけるアトピー型気管支喘息末梢血好塩基球の運動能 |
| FullText URL | 064_043_051.pdf |
| Author | Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Ochi, Koji| Harada, Hideo| Nakagawa, Saburo| Soda, Ryo| Takahashi, Kiyoshi| Kimura, Ikuro| |
| Abstract | We examined histamine release and morphological changes in basophilic granulocytes from atopic subjects, in response to stimulation with antigen and Ca ionophore A23187. 1. Histamine release and a reduction in the rumber of basophils were more rapid and greater in extent at an early stage of antigen stimulation compared with Ca ionophore A23187 stimulation. 2. Morphological changes in basophils, represented by increased motility, in terms of an increased ratio of short to long axis diameter (L/S ratio), as well as the increased frequency of basophils with localized granules and those with pseudopods, were more often observed antigen stimulation than with Ca ionophore A23187 stimulation. In contrast, morphogical changes in which basophils appeared swollen, showing an increased mean cell diameter and an increased frequency of cells with 5 vacuoles or more were more predominant with Ca ionophore A23187 than with antigen stimulation. The results obtained here show that bridging of IgE receptors is essential to activate basophils and induce increased motility in these cells. |
| Keywords | histamine release (ヒスタミン遊離) increased basophil motility (好塩基球の運動能の亢進) bridging of IgE receptors (LgE 受容体) antigen (抗原) Ca ionophore A23187 |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 43 |
| End Page | 51 |
| ISSN | 0918-7839 |
| language | English |
| File Version | publisher |
| NAID | 120002307677 |
