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ID 69258
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Iguchi, Toshihiro Department of Radiological Technology, Faculty of Health Sciences, Okayama University Kaken ID
Nishikori, Asami Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Sato, Yasuharu Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences ORCID Kaken ID researchmap
Nishimura, Midori Filiz Department of Molecular Hematopathology, Okayama University Graduate School of Health Sciences
Iwaki, Noriko Department of Hematology, National Cancer Center Hospital
Kojima, Katsuhide Department of Radiology, Okayama University Hospital
Asahara, Takashi Department of Radiological Technology, Faculty of Health Sciences, Okayama University
Otsuka, Fumio Department of General Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University ORCID Kaken ID publons researchmap
Maeda, Yoshinobu Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences Kaken ID researchmap
Hiraki, Takao Department of Radiology, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Kaken ID publons researchmap
Abstract
This study retrospectively evaluated the computed tomography (CT) findings of idiopathic multicentric Castleman disease (iMCD) at a single center and compared the CT findings of iMCD-TAFRO with those of iMCD-non-TAFRO. CT images obtained within 30 days before diagnostic confirmation were reviewed for 20 patients with iMCD (8 men and 12 women, mean age 52.8 ± 12.3 years, range 25–74 years). Twelve patients were diagnosed with iMCD-TAFRO, five with iMCD-idiopathic plasmacytic lymphadenopathy, and three with iMCD-not otherwise specified. CT images revealed anasarca and lymphadenopathy in all 20 patients. The iMCD-TAFRO group showed significantly higher frequencies of ascites (100% vs. 37.5%, P = 0.004), gallbladder wall edema (75.0% vs. 12.5%, P = 0.020), periportal collar (91.7% vs. 25.0%, P = 0.004), and anterior mediastinal lesions (non-mass-forming infiltrative lesions) (66.7% vs. 12.5%, P = 0.028). Para-aortic edema tended to be more frequent in patients with the iMCD-TAFRO group (83.3% vs. 37.5%, P = 0.062), while the absence of anterior mediastinal lesions tended to be more frequent in the iMCD-non-TAFRO group (16.7% vs. 62.5%, P = 0.062). These CT findings may have clinical implications for improving the accuracy and speed of iMCD diagnosis and differentiating iMCD-TAFRO from other subtypes.
Keywords
idiopathic multicentric Castleman disease
TAFRO syndrome
computed tomography
Published Date
2024-12-25
Publication Title
Journal of Clinical and Experimental Hematopathology
Volume
volume64
Issue
issue4
Publisher
Japanese Society for Lymphoreticular Tissue Research
Start Page
292
End Page
296
ISSN
1346-4280
NCID
AA11556796
Content Type
Journal Article
language
English
OAI-PMH Set
岡山大学
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© 2024 by The Japanese Society for Lymphoreticular Tissue Research
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isVersionOf https://doi.org/001417179400004
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https://creativecommons.org/licenses/by-nc-sa/4.0/