| ID | 34204 |
| FullText URL | |
| Author |
Nakamura, Yuichi
Yamamoto, Hiroshi
|
| Abstract | (R)-2-Tosyloxypropanal (4) was prepared from D-mannitol in a 7-step sequence (51% overall yield). Addition of dialkyl phosphonates to 4 in the presence of titanium isopropoxide and the subsequent treatment with DBU stereoselectively afforded, in one-pot, fosfomycin dimethyl (5a) and dibenzyl (5b) esters both in 58% isolated yield.
|
| Keywords | Fosfomycin
Epoxidation
C-P Bond Formation
Phosphonate Addition
Diastereoselectivity
|
| Published Date | 2007-12-31
|
| Publication Title |
Heterocycles
|
| Volume | volume74
|
| Issue | issue1
|
| Publisher | The Japan Institute of Heterocyclic Chemistry
|
| Start Page | 983
|
| End Page | 989
|
| ISSN | 1881-0942
|
| Content Type |
Journal Article
|
| Official Url | http://dx.doi.org/10.3987/COM-07-S(W)45
|
| language |
English
|
| Copyright Holders | © The Japan Institute of Heterocyclic Chemistry
|
| File Version | author
|
| Refereed |
True
|
| DOI | |
| Web of Science KeyUT | |
| Submission Path | organic_chemistry/6
|
