JaLCDOI 10.18926/AMO/70456
FullText URL 80_2_141.pdf
Author Sakamoto-Tokunaga, Moe| Katsuyama, Takayuki| Matoba, Masaki| Tamura, Tomokazu| Kubota, Natsuki| Terajima, Yuya| Shidahara, Kenta| Hirose, Kei| Matsumoto, Kazuya| Nawachi, Shoichi| Nakadoi, Takato| Katayama, Yu| Hayashi, Keigo| Miyawaki, Yoshia| Katsuyama, Eri| Watanabe, Haruki| Takano-Narazaki, Mariko| Matsumoto, Yoshinori| Sada, Ken-Ei| Tsuji, Shuma| Gotoh, Kazuyoshi| Fukushima, Shinnosuke| Hagiya, Hideharu| Wada, Jun|
Abstract VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory somatic) syndrome has a poor prognosis, with infections being a major cause of death. Raoultella ornithinolytica is an environmental bacterium found predominantly in soil and water. Although R. ornithinolytica can cause various infections, necrotizing fasciitis due to this bacterium has not been reported. We describe the case of an 84-year-old Japanese male with VEXAS syndrome who developed septic shock and necrotizing fasciitis while he was under immunosuppressive therapy. The pathogen was initially misidentified as R. planticola by mass spectrometry but later confirmed by whole-genome sequencing as extended spectrum β-lactamase (ESBL) produced by R. ornithinolytica. Although a life-saving leg amputation was required, the patient recovered with appropriate antibiotic therapy. R. ornithinolytica is thus able to cause severe skin infections in immunocompromised individuals.
Keywords necrotizing fasciitis Raoultella ornithinolytica VEXAS syndrome whole-genome sequence
Amo Type Case Report
Publication Title Acta Medica Okayama
Published Date 2026-04
Volume volume80
Issue issue2
Publisher Okayama University Medical School
Start Page 141
End Page 145
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2026 by Okayama University Medical School
File Version publisher
Refereed True
FullText URL fulltext.pdf
Author Belangoy, Keith Pardillada| Nishimura, Yoshito| Harada, Ko| Hagiya, Hideharu| Vu, Quynh Thi| Ouddoud, Hanane| Lescano, Judah Israel Ong| Yamamoto, Michio| Takeda, Tatsuaki| Hamano, Hirofumi| Koyama, Toshihiro| Zamami, Yoshito|
Keywords Age-standardized mortality rate Global health Mortality trends Sociodemographic index Systemic sclerosis
Published Date 2026-03-06
Publication Title Clinical Rheumatology
Volume volume45
Issue issue5
Publisher Springer Science and Business Media LLC
Start Page 2741
End Page 2748
ISSN 0770-3198
NCID AA10623843
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2026
File Version publisher
PubMed ID 41790357
DOI 10.1007/s10067-026-07995-2
Web of Science KeyUT 001712341500001
Related Url isVersionOf https://doi.org/10.1007/s10067-026-07995-2
FullText URL fulltext.pdf
Author Fukushima, Shinnosuke| Tsuji, Shuma| Gotoh, Kazuyoshi| Iio, Koji| Ogawa, Sakura| Koyanagi, Norihito| Ito, Yuji| Koganemaru, Hiroshi| Yoshida, Atsushi| Hagiya, Hideharu|
Keywords blaZ Cefazolin inoculum effect Methicillin-susceptible Staphylococcus aureus Nitrocefin rapid test β-lactamase
Published Date 2026-07
Publication Title Diagnostic Microbiology and Infectious Disease
Volume volume115
Issue issue3
Publisher Elsevier BV
Start Page 117345
ISSN 0732-8893
NCID AA10623322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 The Author(s).
File Version publisher
PubMed ID 41785539
DOI 10.1016/j.diagmicrobio.2026.117345
Related Url isVersionOf https://doi.org/10.1016/j.diagmicrobio.2026.117345
FullText URL fulltext.pdf
Author Hagiya, Hideharu| Nishimura, Yoshito| Harada, Ko| Yamamoto, Maki| Takeda, Tatsuaki| Vu, Quynh Thi| Belangoy, Keith Pardillada| Ouddoud, Hanane| Zamami, Yoshito| Koyama, Toshihiro|
Keywords Aging Locally weighted regression model Infection Clostridioides difficile Disparity
Published Date 2026-03
Publication Title International Journal of Infectious Diseases
Volume volume164
Publisher Elsevier BV
Start Page 108315
ISSN 1201-9712
NCID AA11238338
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 41456768
DOI 10.1016/j.ijid.2025.108315
Web of Science KeyUT 001678827200001
Related Url isVersionOf https://doi.org/10.1016/j.ijid.2025.108315
Author Fukushima, Shinnosuke| Sumida, Takaomi| Kawamata, Osamu| Hidani, Yoshimi| Hagiya, Hideharu|
Keywords Epidemiology Japanese spotted fever Spotted fever group rickettsiae Tick bite Tick-borne disease
Note © 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2027.|
Published Date 2026-03
Publication Title Journal of Infection and Chemotherapy
Volume volume32
Issue issue3
Publisher Elsevier BV
Start Page 102931
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
File Version author
PubMed ID 41720337
DOI 10.1016/j.jiac.2026.102931
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2026.102931
Author Ogawa, Sakura| Fukushima, Shinnosuke| Yamamoto, Mari| Tsuji, Shuma| Gotoh, Kazuyoshi| Hagiya, Hideharu|
Note © 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Feb. 2027.|
Published Date 2026-03
Publication Title Journal of Infection and Chemotherapy
Volume volume32
Issue issue3
Publisher Elsevier BV
Start Page 102933
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2026 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
File Version author
PubMed ID 41707498
DOI 10.1016/j.jiac.2026.102933
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2026.102933
FullText URL fulltext.pdf
Author Takeuchi, Junko S| Matsunaga, Nobuaki| Tsukada, Ai| Iwamoto, Noriko| Fuwa, Noriko| Ichikawa, Takahiro| Kato, Yasuyuki| Tomita, Yuka| Kitagawa, Hiroki| Yamato, Masaya| Aoyagi, Tetsuji| Hagiya, Hideharu| Hase, Ryota| Hatakeyama, Shuji| Inaba, Tohru| Izumikawa, Koichi| Takesue, Yoshio| Kimura, Moto| Ohmagari, Norio|
Keywords influenza a nasal vestibular swab nasopharyngeal swab rapid diagnostics rt-qpcr saliva sari
Published Date 2026-01-05
Publication Title Cureus
Volume volume18
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page e100872
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Copyright 2026 Takeuchi et al.
File Version publisher
PubMed ID 41658625
DOI 10.7759/cureus.100872
Related Url isVersionOf https://doi.org/10.7759/cureus.100872
FullText URL fulltext.pdf
Author Nishio, Ayano| Iwamuro, Masaya| Inokuchi, Toshihiro| Ishiguro, Mikako| Aoyama, Yuki| Takahara, Masahiro| Hiraoka, Sakiko| Oguni, Kohei| Hagiya, Hideharu| Matsuoka, Yuto| Kanazawa, Tomoyuki| Otsuka, Motoyuki|
Keywords crohn’s disease (cd) group a streptococcus immunosuppression intestinal obstruction streptococcal toxic shock syndrome (stss)
Published Date 2025-12-26
Publication Title Cureus
Volume volume17
Issue issue12
Publisher Springer Science and Business Media LLC
Start Page e100138
ISSN 2168-8184
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © Copyright 2025 Nishio et al.
File Version publisher
PubMed ID 41589146
DOI 10.7759/cureus.100138
Related Url isVersionOf https://doi.org/10.7759/cureus.100138
JaLCDOI 10.18926/AMO/70073
FullText URL 80_1_055.pdf
Author Akazawa, Hidemasa| Hagiya, Hideharu| Fukushima, Shinnosuke| Yamamoto, Shohei| Nakano, Yasuhiro| Otsuka, Fumio|
Abstract In Japan, antiviral agents for COVID-19 were freely available until September 2023 as part of national policy. This study evaluated changes in these agents’ prescribing patterns and the patient outcomes following the policy shift. We conducted a multicenter retrospective study at four hospitals in Japan’s Okayama and Kagawa prefectures from January 2022 to March 2024. The study period was divided into the public-expenditure phase (January 2022 to September 2023) and the post-expenditure phase (October 2023 to March 2024). We extracted the hospitalized patients’ clinical data from the electronic database. The study’s primary outcome was the antiviral prescription rate; the secondary outcome was in-hospital mortality. Among the 302 hospitalized patients (median age 85 years), 52.0% were classified as having a mild condition. Of the patients with mild conditions, 37.7% were diagnosed in outpatient settings prior to hospitalization. During the public-expenditure phase, 47.4% of the patients received antivirals as outpatients, mainly molnupiravir (80.9%). In the post-expenditure period, 80.0% of the patients were prescribed antivirals, mostly molnupiravir (91.7%). The antiviral prescription rate was significantly higher after the policy change. The overall in-hospital mortality was 15.8%, with no significant difference between the two periods (17.0% vs. 10.5%). Despite the termination of government funding, antiviral prescriptions remained frequent at community hospitals located in highly aging regions of western Japan such as Okayama and Kagawa prefectures. Mortality remains high among the elderly, highlighting the need for continued antiviral therapy and booster vaccinations.
Keywords coronavirus disease 2019 public expenditure prescribing pattern prognosis Japan
Amo Type Original Article
Publication Title Acta Medica Okayama
Published Date 2026-02
Volume volume80
Issue issue1
Publisher Okayama University Medical School
Start Page 55
End Page 62
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language English
Copyright Holders Copyright Ⓒ 2026 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 41748150
Web of Science KeyUT 001712994500007
FullText URL fulltext.pdf
Author Fukushima, Shinnosuke| Uchiyama, Jumpei| Kawakami, Yoshio| Matsuura, Yoshiko| Sugihara, Satoru| Morizane, Shin| Muenraya, Poowadon| Hagiya, Hideharu|
Keywords Genome sequence Lymphadenitis Mycobacterium mageritense Skin and soft tissue infections Rapidly growing mycobacteria
Published Date 2026-01-16
Publication Title Tropical Medicine and Health
Volume volume54
Issue issue1
Publisher Springer Science and Business Media LLC
Start Page 19
ISSN 1349-4147
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2026.
File Version publisher
PubMed ID 41546126
DOI 10.1186/s41182-026-00904-y
Web of Science KeyUT 001667707600001
Related Url isVersionOf https://doi.org/10.1186/s41182-026-00904-y
FullText URL fulltext20260111-04.pdf fig20260111-04.pdf table20260111-04.pdf suppl_fig20260111-04.pdf suppl_table20260111-04.pdf
Author Kajita, Shiho| Hagiya, Hideharu| Okita, Atsushi| Haruki, Yuto| Yamada, Haruto| Inoue, Yasurou| Higashionna, Tsukasa| Satou, Kana| Torigoe, Fumihiro| Iwamoto, Shinobu| Yoshida, Mika| Yamane, Yumiko| Kenmotsu, Hiroki| Sugimura, Satoru| Fujiwara, Yutaka| Ikeda, Fusao| Koyama, Toshihiro| Yoshida, Chikamasa| Andou, Shinichirou| Suwaki, Toshimitsu|
Keywords Antimicrobial resistance Antimicrobial stewardship Full-time equivalent Infection prevention and control Trend analysis
Note © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in May 2026.|
Published Date 2025-07
Publication Title Journal of Infection and Chemotherapy
Volume volume31
Issue issue7
Publisher Elsevier BV
Start Page 102730
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
File Version author
PubMed ID 40373974
DOI 10.1016/j.jiac.2025.102730
Web of Science KeyUT 001499520800001
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2025.102730
FullText URL fulltext.pdf
Author Akazawa, Hidemasa| Fukushima, Shinnosuke| Higuchi, Toshie| Miyoshi, Tomoko| Nakano, Yasuhiro| Iio, Koji| Akamatsu, Yukinobu| Haruki, Yuto| Iwamoto, Yoshitaka| Tanaka, Shuichi| Fujisato, Shun| Ako, Soichiro| Hagiya, Hideharu|
Keywords candida bundle candidemia endophthalmitis prognosis propensity score matching
Published Date 2025-12-23
Publication Title Open Forum Infectious Diseases
Volume volume13
Issue issue1
Publisher Oxford University Press (OUP)
Start Page ofaf790
ISSN 2328-8957
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2025.
File Version publisher
PubMed ID 41502907
DOI 10.1093/ofid/ofaf790
Web of Science KeyUT 001654799400001
Related Url isVersionOf https://doi.org/10.1093/ofid/ofaf790
Author Sazumi, Yosuke| Fukushima, Shinnosuke| Hagiya, Hideharu| Kato, Atsushi| Suyama, Atsuhito| Oguni, Kohei| Gotoh, Kazuyoshi| Kutsuno, Shoko| Hisatsune, Junzo| Sugai, Motoyuki| Tsuji, Shuma| Iio, Koji| Otsuka, Fumio|
Keywords Staphylococcus aureus Sequence type 398 Disseminated infection Immune evasion cluster gene
Note © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Oct. 2026.|
Published Date 2025-12
Publication Title Journal of Infection and Chemotherapy
Volume volume31
Issue issue12
Publisher Elsevier BV
Start Page 102845
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
File Version author
PubMed ID 41161474
DOI 10.1016/j.jiac.2025.102845
Web of Science KeyUT 001611880300001
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2025.102845
Author Fukushima, Shinnosuke| Sano, Takayuki| Kashimoto, Takashige| Hagiya, Hideharu|
Keywords Pseudomonas aeruginosa Catheter-associated urinary tract infection Prostatic abscess Type III secretion system
Note © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Nov. 2026.|
Published Date 2025-12
Publication Title Journal of Infection and Chemotherapy
Volume volume31
Issue issue12
Publisher Elsevier BV
Start Page 102853
ISSN 1341-321X
NCID AA11057978
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 Japanese Society of Chemotherapy, Japanese Association for Infectious Diseases, and Japanese Society for Infection Prevention and Control.
File Version author
PubMed ID 41224175
DOI 10.1016/j.jiac.2025.102853
Web of Science KeyUT 001620607800001
Related Url isVersionOf https://doi.org/10.1016/j.jiac.2025.102853
FullText URL fulltext20260111-01.pdf
Author Nakamoto, Kenta| Hagiya, Hideharu| Fukushima, Shinnosuke| Oguni, Kohei| Yokoyama, Yukika| Iio, Koji| Hirano, Shuichiro| Yaguchi, Takashi| Ban, Sayaka| Watanabe, Akira| Okunobu, Hiroki| Suyama, Atsuhito| Kawaguchi, Marina| Sazumi, Yousuke| Otsuka, Fumio|
Keywords Brain abscess Cladophialophora bantiana Black fungus Phaeohyphomycosis Posaconazole
Note © 2025 SFMM. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Mar. 2026.|
Published Date 2025-06
Publication Title Journal of Medical Mycology
Volume volume35
Issue issue2
Publisher Elsevier BV
Start Page 101548
ISSN 1156-5233
NCID AA11001383
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 SFMM.
File Version author
PubMed ID 40168940
DOI 10.1016/j.mycmed.2025.101548
Web of Science KeyUT 001460918900001
Related Url isVersionOf https://doi.org/10.1016/j.mycmed.2025.101548
FullText URL fulltext.pdf
Author Manabe, Yohei| Hagiya, Hideharu| Fukushima, Shinnosuke| Nakamoto, Kenta| Oguni, Kohei| Akazawa, Hidemasa| Fujita, Yasushi| Kiguchi, Takashi| Iio, Koji|
Keywords Bacteremia Blood stream infection Contamination Incubation time Time to positivity
Published Date 2025-12
Publication Title Diagnostic Microbiology and Infectious Disease
Volume volume113
Issue issue4
Publisher Elsevier BV
Start Page 117030
ISSN 0732-8893
NCID AA10623322
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 40768822
DOI 10.1016/j.diagmicrobio.2025.117030
Web of Science KeyUT 001614938400001
Related Url isVersionOf https://doi.org/10.1016/j.diagmicrobio.2025.117030
FullText URL fulltext.pdf
Author Fukushima, Shinnosuke| Hagiya, Hideharu| Fujimori, Takumi| Iio, Koji|
Keywords 16S rRNA culture-negative Enterobacter hormaechei infected aneurysm
Published Date 2025-11-30
Publication Title Clinical Case Reports
Volume volume13
Issue issue12
Publisher Wiley
Start Page e71586
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 41328201
DOI 10.1002/ccr3.71586
Web of Science KeyUT 001626556200001
Related Url isVersionOf https://doi.org/10.1002/ccr3.71586
FullText URL fulltext.pdf
Author Hagiya, Hideharu| Fukushima, Shinnosuke| Nakamoto, Kenta| Oguni, Kohei|
Keywords Mycobacterium avium complex Mycobacterium intracellulare soft tissue infection tenosynovitis
Published Date 2025-12
Publication Title Clinical Case Reports
Volume volume13
Issue issue12
Publisher Wiley
Start Page e71698
ISSN 2050-0904
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The Author(s).
File Version publisher
PubMed ID 41409891
DOI 10.1002/ccr3.71698
Web of Science KeyUT 001640552900001
Related Url isVersionOf https://doi.org/10.1002/ccr3.71698
FullText URL fulltext.pdf
Author Nakamoto, Kenta| Fukushima, Shinnosuke| Oguni, Kohei| Hagiya, Hideharu|
Keywords Mycobacterium tuberculosis Osteo-articular tuberculosis cold abscess
Published Date 2025-11-05
Publication Title The American Journal of Tropical Medicine and Hygiene
Volume volume113
Issue issue5
Publisher American Society of Tropical Medicine and Hygiene
Start Page 942
End Page 943
ISSN 0002-9637
NCID AA00521439
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders © 2025 The author(s)
File Version publisher
PubMed ID 40858144
DOI 10.4269/ajtmh.25-0313
Web of Science KeyUT 001625314200003
Related Url isVersionOf https://doi.org/
FullText URL fulltext.pdf
Author Harada, Ko| Nishimura, Yoshito| Vu, Quynh Thi| Yamamoto, Maki| Koyama, Toshihiro| Hagiya, Hideharu|
Published Date 2025-06-03
Publication Title ERJ Open Research
Volume volume11
Issue issue6
Publisher European Respiratory Society (ERS)
Start Page 00362-2025
ISSN 2312-0541
Content Type Journal Article
language English
OAI-PMH Set 岡山大学
Copyright Holders ©The authors 2025
File Version publisher
PubMed ID 41333986
DOI 10.1183/23120541.00362-2025
Web of Science KeyUT 001638369600003
Related Url isVersionOf https://doi.org/10.1183/23120541.00362-2025