Wiley Acta Medica Okayama 0305-182X 47 3 2019 Association of masticatory muscle activity with sleep arousal and other concomitant movements during sleep 281 288 EN Haruna Miki Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Hajime Minakuchi Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Mayu Miyagi Department of Stomatgnathic Function and Occlusal Reconstruction, Institute of Biomedical Sciences, Clinical Dentistry, Tokushima University Graduate School Emilio Satoshi Hara Department of Biomaterials, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Shuji Shigemoto Department of Fixed Prosthodontics, School of Dental Medicine, Tsurumi University Yoshitaka Suzuki Department of Stomatgnathic Function and Occlusal Reconstruction, Institute of Biomedical Sciences, Clinical Dentistry, Tokushima University Graduate School Kenji Maekawa Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Yoshizo Matsuka Department of Stomatgnathic Function and Occlusal Reconstruction, Institute of Biomedical Sciences, Clinical Dentistry, Tokushima University Graduate School Glenn T. Clark Advanced Program in Orofacial Pain and Oral Medicine, Ostrow School of Dentistry, University of Southern California Takuo Kuboki Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences OBJECTIVE: This study aims to verify the associations among sleep bruxism (SB), sleep arousal (SA) and concurrent body movements. MATERIAL AND METHODS: Subjects underwent a standard overnight polysomnography test and audio-video recordings. Sleep quality was evaluated according to the Rechtschaffen and Kales criteria, while SA was determined as per the American Sleep Disorders Association criteria. Analyses were performed by an external institution after masking of the subjects' information. SB was assessed based on the presence/absence of rhythmic masticatory muscle activity (RMMA) episodes, which were identified by using electromyography of the masseter muscle. The observed simultaneous movements included lower leg movement (LLM), swallowing, face scratching, head movement, body movement, eye blinking, coughing, licking, sighing, body scratching, lip sucking, somniloquy and yawning. The LLM was determined visually, as well as through an increase in the tibialis electromyogram signal. Other movements were visually assessed using audio-video recordings. The incidences of all the simultaneous movements were compared between RMMA with intercurrent SA (SAwRMMA; RMMA episode derived from a masseter electromyogram showing more than 10% of maximum voluntary contraction) and SA without RMMA (SAw/oRMMA). RESULTS: Fourteen subjects were included in this study (females/males: 4/10, mean age: 31.5 ± 5.7 years). Among these, LLM, swallowing, body movement, licking, body scratching and lip sucking were frequently observed in SAwRMMA episodes than in SAw/oRMMA episodes, significantly. However, the non-specific simultaneous movements were higher observed in SAw/oRMMA episodes than that in SAwRMMA. CONCLUSION: Our results suggest that SB is concurrently activated with LLM in relation to arousal. No potential conflict of interest relevant to this article was reported.

Elsevier B.V. Acta Medica Okayama 1742-7061 57 2017 Biocompatible nanostructured solid adhesives for biological soft tissues 404 413 EN Masahiro Okada Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Akira Nakai Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Satoshi Hara Emilio Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Tetsushi Taguchi Polymeric Biomaterials Group, RCFM, National Institute for Materials Science Takayoshi Nakano Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University Takuya Matsumoto Department of Biomaterials, Okayama University Over the past few years, the development of novel adhesives for biological soft tissue adhesion has gained significant interest. Such adhesives should be non-toxic and biocompatible. In this study, we synthesized a novel solid adhesive using nanostructured hydroxyapatite (HAp) and evaluated its physical adhesion properties through in vitro testing with synthetic hydrogels and mouse soft tissues. The results revealed that HAp-nanoparticle dispersions and HAp-nanoparticle-assembled nanoporous plates showed efficient adhesion to hydrogels. Interestingly, the HAp plates showed different adhesive properties depending upon the shape of their nanoparticles. The HAp plate made up of 17 nm-sized nanoparticles showed an adhesive strength 2.2 times higher than that of the conventional fibrin glue for mouse skin tissues. No potential conflict of interest relevant to this article was reported.