| ID | 69286 |
| FullText URL | |
| Author |
AOKI, KASUMI
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
YOSHITANI, NANA
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
KURIO, NAITO
Department of Oral Surgery, Graduate School of Biomedical Sciences, Tokushima University
YOSHIOKA, NORIE
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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TERAMACHI, JUMPEI
Department of Oral Function and Anatomy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
IKEGAME, MIKA
Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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OKAMURA, HIROHIKO
Department of Oral Morphology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
ORCID
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IBARAGI, SOICHIRO
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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| Abstract | Background/Aim: Bone destruction caused by oral cancer severely impacts patient quality of life. This study aimed to clarify the role of angiogenin (ANG) in osteoclastogenesis and oral cancer-induced bone destruction.
Materials and Methods: Recombinant ANG was used to assess its effects on osteoclast formation and bone resorption activity in bone marrow cultures. ANG-knockdown oral squamous carcinoma HSC-2 cells (ANG-RNAi) were transplanted into intramedullary cavities of femurs. Bone destruction was radiologically analyzed, while angiogenesis and osteoclast induction in the surrounding area of the transplanted lesion were histologically examined. Results: Recombinant ANG promoted osteoclast formation and bone resorption activity. Transplantation of ANG-RNAi cells significantly reduced tumor growth and bone destruction properties compared to transplantation of control cells. Histological analysis revealed lower angiogenesis and fewer osteoclast induction in the ANG-RNAi cells-transplanted group. Conclusion: ANG mediates oral cancer-induced bone destruction by promoting osteoclast formation and resorption. These findings suggest that ANG could be a potential therapeutic target for suppressing tumor growth, angiogenesis, and bone destruction in oral cancer therapy. |
| Keywords | Angiogeninoste
oclastogenesis
oral squamous cell carcinoma
osteoclasts
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| Note | This is an Accepted Manuscript of an article published by International Institute of Anticancer Research.
This fulltext file will be available in Sep. 2025.
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| Published Date | 2025-03
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| Publication Title |
Anticancer Research
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| Volume | volume45
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| Issue | issue3
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| Publisher | International Institute of Anticancer Research
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| Start Page | 1025
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| End Page | 1033
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| ISSN | 0250-7005
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| NCID | AA10625860
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © 2025 International Institute of Anticancer Research (Dr. George J. Delinasios)
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| File Version | author
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| PubMed ID | |
| DOI | |
| Web of Science KeyUT | |
| Related Url | isVersionOf https://doi.org/10.21873/anticanres.17489
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| 助成情報 |
23390463:
癌の骨破壊病変に対する新規ａｎｇｉｏｇｅｎｉｎ阻害剤による分子標的治療の開発
( 文部科学省 / Ministry of Education )
23K27790:
癌骨破壊病変において新規破骨細胞形成促進因子Angiogeninが果たす役割の解明
( 文部科学省 / Ministry of Education )
|
