Evaluation of quercetin as a potential cytoprotector against acetaldehyde using the cultured hepatocyte model with aldehyde dehydrogenase isozyme deficiency

Xu, Yuhang; Sawamoto, Takeshi; Sun, Ruitong; Ishikura, Aki; Munemasa, Shintaro; Murata, Yoshiyuki; Satoh, Ayano; Matsumoto, Akiko; Nakamura, Toshiyuki; Nakamura, Yoshimasa

doi:10.1093/bbb/zbae100

Permalink : https://ousar.lib.okayama-u.ac.jp/70921

ID	70921
FullText URL	fulltext.pdf 475 KB
Author	Xu, Yuhang Graduate School of Environmental and Life Science, Okayama University Sawamoto, Takeshi Graduate School of Environmental, Life, Natural Science and Technology, Okayama University Sun, Ruitong Graduate School of Environmental and Life Science, Okayama University Ishikura, Aki Graduate School of Environmental and Life Science, Okayama University Munemasa, Shintaro Graduate School of Environmental and Life Science, Okayama University ORCID Murata, Yoshiyuki Graduate School of Environmental and Life Science, Okayama University ORCID Kaken ID publons researchmap Satoh, Ayano Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University ORCID Kaken ID publons researchmap Matsumoto, Akiko Department of Social and Environmental Medicine, Saga University Nakamura, Toshiyuki Graduate School of Environmental and Life Science, Okayama University Nakamura, Yoshimasa Graduate School of Environmental and Life Science, Okayama University ORCID Kaken ID publons researchmap
Abstract	Protective effect of quercetin against acetaldehyde was evaluated using the cultured hepatocyte models with aldehyde dehydrogenase (ALDH) isozyme deficiency (aldh2-kd and aldh1a1-kd). The quercetin-induced cytoprotection against acetaldehyde in the ALDH1A1-deficient mutant (aldh1a1-kd) was weaker than that in the wild type. Furthermore, quercetin did not enhance the ALDH activity in aldh1a1-kd cells, suggesting that ALDH1A1 is involved in quercetin-induced cytoprotection.
Keywords	quercetin acetaldehyde aldehyde dehydrogenase cytoprotection
Published Date	2024-07-11
Publication Title	Bioscience, Biotechnology, and Biochemistry
Volume	volume88
Issue	issue10
Publisher	Oxford University Press (OUP)
Start Page	1199
End Page	1202
ISSN	1347-6947
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024.
File Version	publisher
PubMed ID	38991992
DOI	10.1093/bbb/zbae100
Web of Science KeyUT	001282385500001
Related Url	isVersionOf https://doi.org/10.1093/bbb/zbae100
License	https://creativecommons.org/licenses/by/4.0/
Citation	Yuhang Xu, Takeshi Sawamoto, Ruitong Sun, Aki Ishikura, Shintaro Munemasa, Yoshiyuki Murata, Ayano Satoh, Akiko Matsumoto, Toshiyuki Nakamura, Yoshimasa Nakamura, Evaluation of quercetin as a potential cytoprotector against acetaldehyde using the cultured hepatocyte model with aldehyde dehydrogenase isozyme deficiency, Bioscience, Biotechnology, and Biochemistry, Volume 88, Issue 10, October 2024, Pages 1199–1202, https://doi.org/10.1093/bbb/zbae100
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