気管支喘息臨床病型に対するTリンパ球の関与の検討

気管支喘息症例の臨床病型に対するTリンパ球の役割を明らかにするために,気管支肺胞洗浄液中のCD3,CD4,CD8陽性細胞の比率を検討した｡1.Ia気管支攣縮型におけるCD3陽性細胞は75.6±6.52%,Ib:過分泌型では75.4±16.5%,Ⅱ:細気管支閉塞型では61.0±12.5%であり,いずれの病型においても有意な差は認められなかった｡2.CD4陽性細胞についてはIa型47.4±6.11%,Ib型39.5±8.70%,Ⅱ型46.3±6.91%,CD8陽性細胞についてはIa型28.3±8.77%,Ib型35.5±12.3%,Ⅱ型29.4±11.5%と過分泌型 で他の2病型とは違う傾向を示したが,有意ではなかった｡3.活性化を示すHLA-DR陽性細胞はCD4,CD8陽性細胞とも気管支攣縮型で高い傾向が認 められたが有意ではなかった｡以上,今回の検討では各臨床病型間でTリンパ球の関与に明らかな差は見られなかったが,気管支攣縮型に対する活性型Tリンパ球より強い関与の可能性が示唆された｡

To clarify the role of T lymphocyte to patho physio logical changls in He aiways, the relationship between T cell subpopulation in BALF and each clinical asthma type were investigated. The proportion of BALF CD3 +T cells in patients with Ia : simple bronchoconstriction type was 75.6±6.52%, 75.4±16.5% in those with Ib : hypersecretion type and 61.0±12.5% in those with Ⅱ : bronchiolar obstruction type. No siginificant differences were observed between 3 asthma types. The proportion of BALF CD4 +T cells and CD8 +T cells revealed different tendency in patients with type Ib, compaired to patients with type Ia or type Ⅱ, but this was not significant. A higher proportion of CD4 + and CD8 +T cells in BALF expressing the T cell activation marker HLA-DR was observed in patients with type Ia. compared to those with other clinial asthma types. However, these were not significant.