Matsumoto, Yoshinori - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

A pilot transcriptomic study of a novel multitargeted BRT regimen for anti–MDA5 antibody-positive dermatomyositis: improving survival over conventional therapy

FullText URL	fulltext.pdf
Author	Tokunaga, Moe\| Nakai, Yu\| Sato, Yoshiharu\| Hiratsuka, Mitori\| Matsumoto, Yoshinori\| Nakatsue, Takeshi\| Saeki, Takako\| Umayahara, Takatsune\| Wada, Jun\| Koyama, Yoshinobu\|
Keywords	anti-MDA5 antibody-positive dermatomyositis (MDA5-DM) JAK inhibitor baricitinib rituximab multitargeted treatment IFN signature transcriptome analysis
Published Date	2025-08-07
Publication Title	Frontiers in Immunology
Volume	volume16
Publisher	Frontiers Media SA
Start Page	1568338
ISSN	1664-3224
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 Tokunaga, Nakai, Sato, Hiratsuka, Matsumoto, Nakatsue, Saeki, Umayahara, Wada and Koyama.
File Version	publisher
PubMed ID	40852724
DOI	10.3389/fimmu.2025.1568338
Web of Science KeyUT	001554021400001
Related Url	isVersionOf https://doi.org/10.3389/fimmu.2025.1568338

Successful Treatment for Life Threatening Recurrent Non-traumatic Rectus Sheath Hematoma in a Case with Microscopic Polyangiitis with Rapidly Progressive Glomerulonephritis

FullText URL	fulltext.pdf
Author	Nakanoh, Hiroyuki\| Takeuchi, Hidemi\| Morimoto, Shiho\| Terajima, Yuya\| Okamoto, Shugo\| Onishi, Yasuhiro\| Tanaka, Keiko\| Katsuyama, Takayuki\| Tsuji, Kenji\| Matsumoto, Yoshinori\| Tanabe, Katsuyuki\| Morinaga, Hiroshi\| Uka, Mayu\| Tomita, Koji\| Uchida, Haruhito A.\| Hiraki, Takao\| Wada, Jun\|
Keywords	rectus sheath hematoma microscopic polyangiitis hemodialysis
Published Date	2024-12-01
Publication Title	Internal Medicine
Volume	volume63
Issue	issue23
Publisher	Japanese Society of Internal Medicine
Start Page	3243
End Page	3248
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	38658341
DOI	10.2169/internalmedicine.3239-23
Web of Science KeyUT	001389172700020
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.3239-23

Immunometabolic Regulation of Innate Immunity in Systemic Lupus Erythematosus

JaLCDOI	10.18926/AMO/68722
FullText URL	79_3_147.pdf
Author	Watanabe, Haruki\| Matsumoto, Yoshinori\| Wada, Jun\|
Abstract	Pathogens or their components can induce long-lasting changes in the behavior of innate immune cells, a process analogous to “training” for future threats or environmental adaptation. However, such training can sometimes have unintended consequences, such as the development of autoimmunity. Systemic lupus erythematosus (SLE) is a chronic and heterogeneous autoimmune disease characterized by the production of autoantibodies and progressive organ damage. Innate immunity plays a central role in its pathogenesis, contributing through impaired clearance of apoptotic cells, excessive type I interferon production, and dysregulated formation of neutrophil extracellular traps. Recent studies have revealed that metabolites and nucleic acids derived from mitochondria, a crucial energy production site, directly regulate type I interferon and anti-inflammatory cytokine production. These insights have fueled interest in targeting metabolic pathways as a novel therapeutic approach for SLE, offering promise for improving long-term patient outcomes.
Keywords	systemic lupus erythematosus interferon tricarboxylic acid cycle innate immune memory trained immunity
Amo Type	Review
Publication Title	Acta Medica Okayama
Published Date	2025-06
Volume	volume79
Issue	issue3
Publisher	Okayama University Medical School
Start Page	147
End Page	155
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2025 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	40574253
Web of Science KeyUT	001524768800001

PARylation-mediated post-transcriptional modifications in cancer immunity and immunotherapy

FullText URL	fulltext.pdf
Author	Matsumoto, Kazuya\| Matsumoto, Yoshinori\| Wada, Jun\|
Keywords	PARylation cancer post-transcriptional regulation ubiquitylation immune system
Published Date	2025-03-11
Publication Title	Frontiers in Immunology
Volume	volume16
Publisher	Frontiers Media
Start Page	1537615
ISSN	1664-3224
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 Matsumoto, Matsumoto and Wada.
File Version	publisher
PubMed ID	40134437
DOI	10.3389/fimmu.2025.1537615
Web of Science KeyUT	001450818200001
Related Url	isVersionOf https://doi.org/10.3389/fimmu.2025.1537615

Dyspnea with Hemidiaphragm Elevation in a Patient with Giant Cell Arteritis: A Case Report

FullText URL	fulltext.pdf
Author	Asano, Yosuke\| Matsumoto, Yoshinori\| Kubota, Natsuki\| Terajima, Yuya\| Matsumoto, Kazuya\| Shidahara, Kenta\| Hirose, Kei\| Nakadoi, Takato\| Nawachi, Shoichi\| Katayama, Yu\| Miyawaki, Yoshia\| Katsuyama, Eri\| Katsuyama, Takayuki\| Takano-Narazaki, Mariko\| Sada, Ken-Ei\| Wada, Jun\|
Keywords	giant cell arteritis dyspnea hemidiaphragm elevation phrenic nerve paralysis FDG-PET case report
Published Date	2025
Publication Title	Internal Medicine
Publisher	Japanese Society of Internal Medicine
Start Page	4055-24
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	Ⓒ The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	39814390
DOI	10.2169/internalmedicine.4055-24
Web of Science KeyUT	001398216000001
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.4055-24

Association between discontinuity of care and patient trust in the usual rheumatologist among patients with systemic lupus erythematosus: a cross-sectional study

FullText URL	fulltext.pdf
Author	Katayama, Yu\| Miyawaki, Yoshia\| Shidahara, Kenta\| Nawachi, Shoichi\| Asano, Yosuke\| Katsuyama, Eri\| Katsuyama, Takayuki\| Takano-Narazaki, Mariko\| Matsumoto, Yoshinori\| Oguro, Nao\| Yajima, Nobuyuki\| Ishikawa, Yuichi\| Sakurai, Natsuki\| Hidekawa, Chiharu\| Yoshimi, Ryusuke\| Ohno, Shigeru\| Ichikawa, Takanori\| Kishida, Dai\| Shimojima, Yasuhiro\| Sada, Ken-Ei\| Wada, Jun\| Thom, David H.\| Kurita, Noriaki\|
Keywords	Systemic lupus erythematosus Patient-physician relationship Outpatient visits Patient trust Discontinuity of care
Note	The version of record of this article, first published in Arthritis Research & Therapy, is available online at Publisher’s website: http://dx.doi.org/10.1186/s13075-024-03428-0\|
Published Date	2024-11-11
Publication Title	Arthritis Research & Therapy
Volume	volume26
Issue	issue1
Publisher	BMC
Start Page	195
ISSN	1478-6354
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024.
File Version	publisher
PubMed ID	39529181
DOI	10.1186/s13075-024-03428-0
Web of Science KeyUT	001352382300001
Related Url	isVersionOf https://doi.org/10.1186/s13075-024-03428-0

シェーグレン症候群

Title Alternative	Sjögren's syndrome
Author	Matsumoto, Yoshinori\|
Keywords	シェーグレン症候群疫学治療特定疾患
Publication Title	Journal of Okayama Medical Association
Published Date	2024-08-01
Volume	volume136
Issue	issue2
Start Page	77
End Page	79
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.136.77
language	Japanese
Copyright Holders	Copyright (c) 2024 岡山医学会
File Version	publisher
DOI	10.4044/joma.136.77

Immunosuppressive Treatment for an anti-U1 Ribonucleoprotein Antibody-positive Patient with Pulmonary Arterial Hypertension

FullText URL	fulltext.pdf
Author	Matsumoto, Kazuya\| Miyawaki, Yoshia\| Katsuyama, Takayuki\| Nakadoi, Takato\| Shidahara, Kenta\| Hirose, Kei\| Nawachi, Shoichi\| Asano, Yosuke\| Katayama, Yu\| Katsuyama, Eri\| Takano-Narazaki, Mariko\| Matsumoto, Yoshinori\| Mori, Atsushi\| Akagi, Satoshi\| Sada, Ken-Ei\| Wada, Jun\|
Keywords	pulmonary arterial hypertension anti-U1 RNP antibody corticosteroid cyclophosphamide
Published Date	2024-03-01
Publication Title	Internal Medicine
Volume	volume63
Issue	issue5
Publisher	Japanese Society of Internal Medicine
Start Page	671
End Page	676
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	37468249
DOI	10.2169/internalmedicine.1407-22
Web of Science KeyUT	001179673600001
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.1407-22

The first presentation of a case of nail-patella syndrome newly diagnosed at the onset of rheumatoid arthritis: a case report

FullText URL	fulltext.pdf
Author	Matsumoto, Kazuya\| Matsumoto, Yoshinori\| Nawachi, Shoichi\| Asano, Yosuke\| Katayama, Yu\| Miyawaki, Yoshia\| Katsuyama, Takayuki\| Katsuyama, Eri\| Nasu, Yoshihisa\| Sada, Ken-Ei\| Wada, Jun\|
Keywords	Nail-patella syndrome Rheumatoid arthritis Joint dislocation Iliac horn Case report
Note	The version of record of this article, first published in BMC Musculoskeletal Disorders, is available online at Publisher’s website: http://dx.doi.org/10.1186/s12891-024-07242-2\|
Published Date	2024-02-14
Publication Title	BMC Musculoskeletal Disorders
Volume	volume25
Issue	issue1
Publisher	BMC
Start Page	139
ISSN	1471-2474
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024.
File Version	publisher
PubMed ID	38355529
DOI	10.1186/s12891-024-07242-2
Web of Science KeyUT	001162669400002
Related Url	isVersionOf https://doi.org/10.1186/s12891-024-07242-2

Association of one-point glucocorticoid-free status with chronic damage and disease duration in systemic lupus erythematosus: a cross-sectional study

FullText URL	fulltext.pdf
Author	Sada, Ken-ei\| Katayama, Yu\| Asano, Yosuke\| Hayashi, Keigo\| Miyawaki, Yoshia\| Ohashi, Keiji\| Katsuyama, Eri\| Katsuyama, Takayuki\| Takano-Narazaki, Mariko\| Matsumoto, Yoshinori\| Yoshimi, Ryusuke\| Shimojima, Yasuhiro\| Ohno, Shigeru\| Kajiyama, Hiroshi\| Ichinose, Kunihiro\| Sato, Shuzo\| Fujiwara, Michio\| Yajima, Nobuyuki\|
Keywords	systemic lupus erythematosus glucocorticoids outcome assessment health care epidemiology
Published Date	2022-09-27
Publication Title	Lupus Science & Medicine
Volume	volume9
Issue	issue1
Publisher	BMJ
Start Page	e000772
ISSN	2053-8790
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Author(s) (or their employer(s)) 2022.
File Version	publisher
PubMed ID	36167483
DOI	10.1136/lupus-2022-000772
Web of Science KeyUT	000861425300002
Related Url	isVersionOf https://doi.org/10.1136/lupus-2022-000772

PARsylation-mediated ubiquitylation: lessons from rare hereditary disease Cherubism

FullText URL	fulltext20230619-01.pdf
Author	Matsumoto, Yoshinori\| Rottapel, Robert\|
Keywords	PARsylation ubiquitylation proteasomal degradation Cherubism tankyrase PARPs
Published Date	2023-05
Publication Title	Trends in Molecular Medicine
Volume	volume29
Issue	issue5
Publisher	Elsevier BV
Start Page	390
End Page	405
ISSN	1471-4914
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 The Authors.
File Version	publisher
PubMed ID	36948987
DOI	10.1016/j.molmed.2023.02.001
Web of Science KeyUT	000994672600001
Related Url	isVersionOf https://doi.org/10.1016/j.molmed.2023.02.001

好酸球性多発血管炎性肉芽腫症

Title Alternative	Eosinophilic granulomatosis with polyangiitis
FullText URL	134_95.pdf
Author	Matsumoto, Yoshinori\|
Keywords	ANCA関連血管炎好酸球性多発血管炎性肉芽腫症 EGPA
Publication Title	Journal of Okayama Medical Association
Published Date	2022-08-01
Volume	volume134
Issue	issue2
Start Page	95
End Page	98
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.134.95
language	Japanese
Copyright Holders	Copyright (c) 2022 岡山医学会
File Version	publisher
DOI	10.4044/joma.134.95

E3-ubiquitin ligases and recent progress in osteoimmunology

FullText URL	fulltext.pdf
Author	Asano, Yosuke\| Matsumoto, Yoshinori\| Wada, Jun\| Rottapel, Robert\|
Keywords	E3-ubiquitin ligases ubiquitylation proteasomal degradation osteoimmunology cherubism
Published Date	2023-02-23
Publication Title	Frontiers in Immunology
Volume	volume14
Publisher	Frontiers Media
Start Page	1120710
ISSN	1664-3224
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 Asano, Matsumoto, Wada and Rottapel.
File Version	publisher
PubMed ID	36911671
DOI	10.3389/fimmu.2023.1120710
Web of Science KeyUT	000945836300001
Related Url	isVersionOf https://doi.org/10.3389/fimmu.2023.1120710

Real-world data on vitamin D supplementation and its impacts in systemic lupus erythematosus: Cross-sectional analysis of a lupus registry of nationwide institutions (LUNA)

FullText URL	fulltext.pdf
Author	Hayashi, Keigo\| Sada, Ken-Ei\| Asano, Yosuke\| Katayama, Yu\| Ohashi, Keiji\| Morishita, Michiko\| Miyawaki, Yoshia\| Watanabe, Haruki\| Katsuyama, Takayuki\| Narazaki, Mariko\| Matsumoto, Yoshinori\| Yajima, Nobuyuki\| Yoshimi, Ryusuke\| Shimojima, Yasuhiro\| Ohno, Shigeru\| Kajiyama, Hiroshi\| Ichinose, Kunihiro\| Sato, Shuzo\| Fujiwara, Michio\| Wada, Jun\|
Published Date	2022-06-29
Publication Title	Plos One
Volume	volume17
Issue	issue6
Publisher	Public Library Science
Start Page	e0270569
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 Hayashi et al.
File Version	publisher
PubMed ID	35767524
DOI	10.1371/journal.pone.0270569
Web of Science KeyUT	000892027900189
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0270569

Tankyrase represses autoinflammation through the attenuation of TLR2 signaling

FullText URL	fulltext20220509-2.pdf
Author	Matsumoto, Yoshinori\| Dimitriou, Ioannis D.\| La Rose, Jose\| Lim, Melissa\| Camilleri, Susan\| Law, Napoleon\| Adissu, Hibret A.\| Tong, Jiefei\| Moran, Michael F.\| Chruscinski, Andrzej\| He, Fang\| Asano, Yosuke\| Katsuyama, Takayuki\| Sada, Ken-ei\| Wada, Jun\| Rottapel, Robert\|
Published Date	2022-4-1
Publication Title	Journal of Clinical Investigation
Volume	volume132
Issue	issue7
Publisher	American Society for Clinical Investigation
Start Page	e140869
ISSN	1558-8238
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022, Matsumoto et al.
File Version	publisher
PubMed ID	35274528
DOI	10.1172/jci140869
Web of Science KeyUT	000783678600007
Related Url	isVersionOf https://doi.org/10.1172/jci140869

RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion (vol 11, 665273, 2021)

FullText URL	fulltext.pdf
Author	He, Fang\| Matsumoto, Yoshinori\| Asano, Yosuke\| Yamamura, Yuriko\| Katsuyama, Takayuki\| Rose, Jose La\| Tomonobu, Nahoko\| Komalasari, Ni Luh Gede Yoni\| Sakaguchi, Masakiyo\| Rottapel, Robert\| Wada, Jun\|
Keywords	ABL-Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion
Note	A Corrigendum on RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion By He F, Matsumoto Y, Asano Y, Yamamura Y, Katsuyama T, Rose JL, Tomonobu N, Komalasari NLGY, Sakaguchi M, Rottapel R and Wada J (2021). Front. Oncol. 11:665273. doi: 10.3389/fonc.2021.665273 Erratum for https://ousar.lib.okayama-u.ac.jp/62214\|
Published Date	2021-07-20
Publication Title	Frontiers In Oncology
Volume	volume11
Publisher	Frontiers Media SA.
Start Page	729192
ISSN	2234-943X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, Rose,Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.
File Version	publisher
PubMed ID	34354958
DOI	10.3389/fonc.2021.729192
Web of Science KeyUT	000680472200001
Related Url	isVersionOf https://doi.org/10.3389/fonc.2021.729192

RUNX2 Phosphorylation by Tyrosine Kinase ABL Promotes Breast Cancer Invasion

FullText URL	fulltext.pdf
Author	He, Fang\| Matsumoto, Yoshinori\| Asano, Yosuke\| Yamamura, Yuriko\| Katsuyama, Takayuki\| La Rose, Jose\| Tomonobu, Nahoko\| Komalasari, Ni Luh Gede Yoni\| Sakaguchi, Masakiyo\| Rottapel, Robert\| Wada, Jun\|
Keywords	ABL Abelson murine leukemia viral oncogene homolog Runx2 (runt-related transcription factor 2) tyrosine phosphorylation invasion
Note	Erratum in https://ousar.lib.okayama-u.ac.jp/62331\|
Published Date	2021-05-31
Publication Title	Frontiers In Oncology
Volume	volume11
Publisher	Frontiers Media S.A.
Start Page	665273
ISSN	2234-943X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 He, Matsumoto, Asano, Yamamura, Katsuyama, La Rose, Tomonobu, Komalasari, Sakaguchi, Rottapel and Wada.
File Version	publisher
PubMed ID	34136397
DOI	10.3389/fonc.2021.665273
NAID	120007089841
Web of Science KeyUT	000661158800001
Related Url	isVersionOf https://doi.org/10.3389/fonc.2021.665273

Association of glucocorticoid doses and emotional health in lupus low disease activity state (LLDAS): a cross-sectional study

FullText URL	fulltext.pdf
Author	Miyawaki, Yoshia\| Shimizu, Sayaka\| Ogawa, Yusuke\| Sada, Ken-Ei\| Katayama, Yukitoshi\| Asano, Yosuke\| Hayashi, Keigo\| Yamamura, Yuriko\| Hiramatsu-Asano, Sumie\| Ohashi, Keiji\| Morishita, Michiko\| Watanabe, Haruki\| Takano-Narazaki, Mariko\| Matsumoto, Yoshinori\| Yajima, Nobuyuki\| Yoshimi, Ryusuke\| Shimojima, Yasuhiro\| Ohno, Shigeru\| Kajiyama, Hiroshi\| Ichinose, Kunihiro\| Sato, Shuzo\| Fujiwara, Michio\| Yamazaki, Hajime\| Yamamoto, Yosuke\| Wada, Jun\| Fukuhara, Shunichi\|
Keywords	Systemic lupus erythematosus Glucocorticoid Emotional health Patient-reported outcome Depression Anxiety Cross-sectional study
Published Date	2021-03-10
Publication Title	Arthritis Research & Therapy
Volume	volume23
Issue	issue1
Publisher	BMC
ISSN	1478-6354
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s). 2021
File Version	publisher
PubMed ID	33691746
DOI	10.1186/s13075-021-02466-2
NAID	120007019117
Web of Science KeyUT	000627856600002
Related Url	isVersionOf https://doi.org/10.1186/s13075-021-02466-2

Granulomatosis with polyangiitis with obstructive pneumonia progressing to hypertrophic pachymeningitis A case report

FullText URL	fulltext.pdf
Author	Hayashi, Keigo\| Watanabe, Haruki\| Yamamura, Yuriko\| Asano, Yosuke\| Katayama, Yukitoshi\| Hiramatsu-Asano, Sumie\| Ohashi, Keiji\| Morishita, Michiko\| Narazaki, Mariko\| Matsumoto, Yoshinori\| Sada, Ken-Ei\| Wada, Jun\|
Keywords	bronchial stenosis granulomatosis with polyangiitis hypertrophic pachymeningitis rituximab
Published Date	2021-01-22
Publication Title	Medicine
Volume	volume100
Issue	issue3
Publisher	Lippincott, Williams & Wilkins
Start Page	e24028
ISSN	0025-7974
NCID	AA00728867
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 the Author(s).
File Version	publisher
PubMed ID	33546000
DOI	10.1097/MD.0000000000024028
Web of Science KeyUT	000612835100080
Related Url	isVersionOf https://doi.org/10.1097/MD.0000000000024028

Risk of higher dose methotrexate for renal impairment in patients with rheumatoid arthritis

FullText URL	fulltext.pdf
Author	Hayashi, Keigo\| Sada, Ken-Ei\| Asano, Yosuke\| Hiramatsu Asano, Sumie\| Yamamura, Yuriko\| Ohashi, Keiji\| Morishita, Michiko\| Watanabe, Haruki\| Narazaki, Mariko\| Matsumoto, Yoshinori\| Wada, Jun\|
Keywords	Nephrology Rheumatology
Published Date	2020-10-30
Publication Title	Scientific Reports
Volume	volume10
Issue	issue1
Publisher	Nature Research
Start Page	18715
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2020
File Version	publisher
PubMed ID	33127957
DOI	10.1038/s41598-020-75655-9
Web of Science KeyUT	000591916900014
Related Url	isVersionOf https://doi.org/10.1038/s41598-020-75655-9