Masuyama, Hisashi - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Decline in and recovery of fertility rates after COVID-19-related state of emergency in Japan

FullText URL	fulltext.pdf
Author	Mitoma, Tomohiro\| Maki, Jota\| Ooba, Hikaru\| Masuyama, Hisashi\|
Published Date	2024-10-08
Publication Title	BMJ Open
Volume	volume14
Issue	issue10
Publisher	BMJ Publishing Group
Start Page	e087657
ISSN	2044-6055
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Author(s) (or their employer(s)) 2024.
File Version	publisher
PubMed ID	39384228
DOI	10.1136/bmjopen-2024-087657
Web of Science KeyUT	001329970500001
Related Url	isVersionOf https://doi.org/10.1136/bmjopen-2024-087657

Evaluating the impact of a trial of labor after cesarean section on labor duration: a retrospective cohort study

FullText URL	fulltext.pdf
Author	Ooba, Hikaru\| Maki, Jota\| Masuyama, Hisashi\|
Keywords	Labor duration Trial of labor after cesarean section Vaginal birth Cesarean section Propensity scores IPTW
Published Date	2024-08-15
Publication Title	BMC Pregnancy and Childbirth
Volume	volume24
Issue	issue1
Publisher	BMC
Start Page	542
ISSN	1471-2393
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024.
File Version	publisher
PubMed ID	39148014
DOI	10.1186/s12884-024-06744-0
Web of Science KeyUT	001291316100002
Related Url	isVersionOf https://doi.org/10.1186/s12884-024-06744-0

Multicenter Remote-Access Simulation of Vaginal Delivery for High-Flexibility Medical Education during the Coronavirus Pandemic

JaLCDOI	10.18926/AMO/67547
FullText URL	78_4_313.pdf
Author	Eto, Eriko\| Maki, Jota\| Yamashita, Noriyuki\| Hasegawa, Toru\| Suemori, Ayano\| Nakato, Hikari\| Oba, Hikaru\| Mitoma, Tomohiro\| Mishima, Sakurako\| Kirino, Satoe\| Ohira, Akiko\| Masuyama, Hisashi\|
Abstract	During the coronavirus pandemic, face-to-face simulation education became impossible. Therefore, we aimed to develop remote-access simulation education with a sense of realism through Information and Communication Technology (ICT) using a perinatal whole-body management and delivery simulator. In September 2021, we administered a multi-center simultaneous remote simulation based on our developed model. Ten universities in the Chugoku–Shikoku region were connected via a web-conferencing system to a live broadcast of a virtual vaginal birth in which a fictional hospitalized pregnant woman experienced accelerated labor and gave birth through vacuum delivery for fetal distress. A Video on Demand (VOD) was made beforehand using a new simulator that allowed for a visual understanding of the process of the inter-vaginal examination. We provided a participatory program that enhanced the sense of realism by combining VOD and real-time lectures on each scenario, with two-way communication between participants and trainee doctors using a chat function. Most participants answered “satisfied” or “very satisfied” with the content, level of difficulty, and level of understanding. From November 2021, we have used the videos of all processes in face-to-face classes. Our construction of a high-flexibility education system using remote simulation in the field of obstetrics and gynecology, especially in the vaginal delivery module, is unique, creative, and sustainable.
Keywords	remote simulator education perinatal simulator information and communication technology high-flexibility education
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2024-08
Volume	volume78
Issue	issue4
Publisher	Okayama University Medical School
Start Page	313
End Page	322
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2024 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	39198985
Web of Science KeyUT	001310576400002

Re-administration of platinum-based chemotherapy for recurrent endometrial cancer: an ancillary analysis of the SGSG-012/GOTIC-004/Intergroup study

FullText URL	fulltext.pdf
Author	Nagao, Shoji\| Nishio, Shin\| Takehara, Kazuhiro\| Sato, Shinya\| Satoh, Toyomi\| Shimada, Muneaki\| Yamaguchi, Satoshi\| Tanabe, Hiroshi\| Takano, Masashi\| Horie, Kouji\| Takei, Yuji\| Imai, Yuichi\| Hibino, Yumi\| Hasegawa, Kosei\| Takekuma, Munetaka\| Nakamura, Kazuto\| Takano, Hirokuni\| Fujiwara, Keiichi\| Masuyama, Hisashi\|
Keywords	Recurrent endometrial cancer Re-administration of platinum-based chemotherapy Platinum-free interval Secondary platinum response
Note	The version of record of this article, first published in International Journal of Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10147-024-02585-1\|
Published Date	2024-07-13
Publication Title	International Journal of Clinical Oncology
Volume	volume29
Issue	issue10
Publisher	Springer Science and Business Media LLC
Start Page	1594
End Page	1601
ISSN	1341-9625
NCID	AA11086579
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	39001945
DOI	10.1007/s10147-024-02585-1
Web of Science KeyUT	001272243200001
Related Url	isVersionOf https://doi.org/10.1007/s10147-024-02585-1

Efficacy and safety of olaparib, olaparib plus bevacizumab and niraparib maintenance treatment in Japanese patients with platinum-sensitive advanced ovarian cancer

FullText URL	fulltext.pdf
Author	Nakamura, Keiichiro\| Matsuoka, Hirofumi\| Yorimitsu, Masae\| Ogawa, Mariko\| Kanemori, Miho\| Sueoka, Kotaro\| Kozai, Ayumi\| Nakamura, Hiroko\| Haruma, Tomoko\| Shiroyama, Yuko\| Hayata, Yuu\| Sugii, Hirokazu\| Ueda, Akiko\| Kurihara, Shuichi\| Urayama, Saiko\| Shimizu, Miyuki\| Masuyama, Hisashi\|
Keywords	olaparib olaparib plus bevacizumab niraparib renal function
Published Date	2023-09-14
Publication Title	Japanese Journal of Clinical Oncology
Volume	volume54
Issue	issue1
Publisher	Oxford University Press (OUP)
Start Page	31
End Page	37
ISSN	1465-3621
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023.
File Version	publisher
PubMed ID	37721176
DOI	10.1093/jjco/hyad125
Web of Science KeyUT	001068527100001
Related Url	isVersionOf https://doi.org/10.1093/jjco/hyad125

Not taking sick leave for gynecologic cancer treatment is negatively associated with returning to the same workplace

FullText URL	fulltext.pdf
Author	Nakamura, Keiichiro\| Matsuoka, Hirofumi\| Kubo, Kotaro\| Shirakawa, Shinsuke\| Ida, Naoyuki\| Haraga, Junko\| Ogawa, Chikako\| Okamoto, Kazuhiro\| Nagao, Shoji\| Masuyama, Hisashi\|
Keywords	returning to the same workplace gynecologic neoplasms sick leave
Published Date	2023-11-23
Publication Title	Japanese Journal of Clinical Oncology
Volume	volume54
Issue	issue3
Publisher	Oxford University Press (OUP)
Start Page	292
End Page	296
ISSN	1465-3621
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023.
File Version	publisher
PubMed ID	37995280
DOI	10.1093/jjco/hyad159
Web of Science KeyUT	001108594700001
Related Url	isVersionOf https://doi.org/10.1093/jjco/hyad159

Assessing the efficacy of simulation-based education for paramedics in extended focused assessment with sonography for trauma under physician guidance

FullText URL	fulltext.pdf
Author	Ohira, Akiko\| Maki, Jota\| Ageta, Kohei\| Nakato, Hikari\| Oba, Hikaru\| Mitoma, Tomohiro\| Mishima, Sakurako\| Tani, Kazumasa\| Kirino, Satoe\| Eto, Eriko\| Nakao, Atsunori\| Masuyama, Hisashi\|
Keywords	Simulation-based education Ultrasound Paramedics FAST
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-54779-2\|
Published Date	2024-02-20
Publication Title	Scientific Reports
Volume	volume14
Issue	issue1
Publisher	Nature Portfolio
Start Page	4190
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	38378769
DOI	10.1038/s41598-024-54779-2
Web of Science KeyUT	001173675500048
Related Url	isVersionOf https://doi.org/10.1038/s41598-024-54779-2

Association of Regular Cervical Cancer Screening with Socioeconomic, COVID-19 Infection and Vaccine Status Among Japanese Population: Cohort Observational Study

FullText URL	fulltext.pdf
Author	Mitoma, Tomohiro\| Maki, Jota\| Ooba, Hikaru\| Ogawa, Chikako\| Masuyama, Hisashi\| Tabuchi, Takahiro\|
Keywords	cervical cancer screening social inequality screening hesitation internet survey
Published Date	2024-02-13
Publication Title	International Journal of General Medicine
Volume	volume17
Publisher	Dove Press
Start Page	541
End Page	551
ISSN	1178-7074
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 Mitoma et al.
File Version	publisher
PubMed ID	38371520
DOI	10.2147/IJGM.S453675
Web of Science KeyUT	001162765400001
Related Url	isVersionOf https://doi.org/10.2147/IJGM.S453675

第47回日本女性栄養・代謝学会学術集会開催報告

Title Alternative	The 47th Annual Meeting of the Japan Society of Women's Nutrition and Metabolism
Author	Masuyama, Hisashi\|
Publication Title	Journal of Okayama Medical Association
Published Date	2023-12-01
Volume	volume135
Issue	issue3
Start Page	179
End Page	180
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.135.179
language	Japanese
Copyright Holders	Copyright (c) 2023 岡山医学会
File Version	publisher
DOI	10.4044/joma.135.179

Partner relationships, hopelessness, and health status strongly predict maternal well-being: an approach using light gradient boosting machine

FullText URL	fulltext.pdf
Author	Ooba, Hikaru\| Maki, Jota\| Tabuchi, Takahiro\| Masuyama, Hisashi\|
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-44410-1\|
Published Date	2023-10-09
Publication Title	Scientific Reports
Volume	volume13
Issue	issue1
Publisher	Nature Portfolio
Start Page	17032
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	37813926
DOI	10.1038/s41598-023-44410-1
Web of Science KeyUT	001099954200052
Related Url	isVersionOf https://doi.org/10.1038/s41598-023-44410-1

ADAR1 has an oncogenic function and can be a prognostic factor in cervical cancer

FullText URL	fulltext.pdf
Author	Nakamura, Keiichiro\| Shigeyasu, Kunitoshi\| Okamoto, Kazuhiro\| Matsuoka, Hirofumi\| Masuyama, Hisashi\|
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-30452-y\|
Published Date	2023-03-23
Publication Title	Scientific Reports
Volume	volume13
Issue	issue1
Publisher	Nature Portfolio
Start Page	4720
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	36959226
DOI	10.1038/s41598-023-30452-y
Web of Science KeyUT	001024033600064
Related Url	isVersionOf https://doi.org/10.1038/s41598-023-30452-y

吉備中央町が本邦初の革新的事業連携型国家戦略特区指定を受けて―デジタル田園健康特区と規制改革の実現に向けた大学の役割―

Title Alternative	Kibichuo Town is the first National Strategic Special Zone for innovative business collaboration in Japan: The role of universities in achieving regulatory reform with a vision toward a Digital Garden City Nation
FullText URL	134_115.pdf
Author	Nasu, Yasutomo\| Maki, Jota\| Sakurai, Jun\| Masuyama, Hisashi\| Maeda, Yoshinobu\|
Publication Title	Journal of Okayama Medical Association
Published Date	2022-08-01
Volume	volume134
Issue	issue2
Start Page	115
End Page	118
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.134.115
language	Japanese
Copyright Holders	Copyright (c) 2022 岡山医学会
File Version	publisher
DOI	10.4044/joma.134.115

Short stature in small-for-gestational-age offspring born to mothers with hypertensive disorders of pregnancy

FullText URL	fulltext20230424-01.pdf
Author	Mishima, Sakurako\| Mitsui, Takashi\| Tani, Kazumasa\| Maki, Jota\| Eto, Eriko\| Hayata, Kei\| Washio, Yosuke\| Yoshimoto, Junko\| Tsukahara, Hirokazu\| Masuyama, Hisashi\|
Keywords	Short stature catch-up growth small-for-gestational age premature birth hypertensive disorders of pregnancy
Published Date	2023-03-08
Publication Title	Hypertension in Pregnancy
Volume	volume42
Issue	issue1
Publisher	Taylor and Francis
Start Page	2187623
ISSN	1064-1955
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 The Author(s).
File Version	publisher
PubMed ID	36891613
DOI	10.1080/10641955.2023.2187623
Web of Science KeyUT	000953321900001
Related Url	isVersionOf https://doi.org/10.1080/10641955.2023.2187623

Therapeutic plasma exchange in postpartum HELLP syndrome: a case report

FullText URL	fulltext.pdf
Author	Kojima, Nana\| Kuroda, Kosuke\| Tani, Makiko\| Kanazawa, Tomoyuki\| Shimizu, Kazuyoshi\| Maki, Jota\| Masuyama, Hisashi\| Morimatsu, Hiroshi\|
Keywords	HELLP syndrome Postpartum Plasma exchange therapy Thrombotic microangiopathy
Published Date	2023-02-20
Publication Title	JA Clinical Reports
Volume	volume9
Issue	issue1
Publisher	Springer
Start Page	9
ISSN	2363-9024
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023.
File Version	publisher
PubMed ID	36805852
DOI	10.1186/s40981-023-00602-2
Web of Science KeyUT	000934508200002
Related Url	isVersionOf https://doi.org/10.1186/s40981-023-00602-2

Protocol for a randomised, placebo-controlled, double-blinded clinical trial on the effect of oestrogen replacement on physical performance to muscle resistance exercise for older women with osteoarthritis of knee joint: the EPOK trial

FullText URL	fulltext.pdf
Author	Mitoma, Tomohiro\| Maki, Jota\| Ooba, Hikaru\| Eto, Eriko\| Takahashi, Kasumi\| Kondo, Tsunemasa\| Ikeda, Tomohiro\| Sakamoto, Yoko\| Mitsuhashi, Toshiharu\| Masuyama, Hisashi\|
Keywords	Oestrogen replacement therapy Knee osteoarthritis Muscle resistance exercise Sarcopenia Physical performance
Published Date	2023-02-18
Publication Title	BMC Geriatrics
Volume	volume23
Issue	issue1
Publisher	BMC
Start Page	104
ISSN	1471-2318
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023.
File Version	publisher
PubMed ID	36800940
DOI	10.1186/s12877-023-03828-y
Web of Science KeyUT	000936860000001
Related Url	isVersionOf https://doi.org/10.1186/s12877-023-03828-y

Tumor size before image-guided brachytherapy is an important factor of local control after radiotherapy for cervical squamous cell carcinoma: analysis in cases using central shielding

FullText URL	fulltext.pdf
Author	Yoshio, Kotaro\| Ihara, Hiroki\| Okamoto, Kazuhiro\| Suzuki, Etsuji\| Ogata, Takeshi\| Sugiyama, Soichi\| Nakamura, Keiichiro\| Nagao, Shoji\| Masuyama, Hisashi\| Hiraki, Takao\|
Keywords	cervical cancer tumor size squamous cell carcinoma image-guided brachytherapy (IGBT) central shielding (CS)
Published Date	2022-07-05
Publication Title	Journal Of Radiation Research
Publisher	Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology
ISSN	0449-3060
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	35791439
DOI	10.1093/jrr/rrac040
Web of Science KeyUT	000820941900001
Related Url	isVersionOf https://doi.org/10.1093/jrr/rrac040

Diffuse myometrium thinning and placenta accreta spectrum in a patient with systemic lupus erythematosus (SLE): a case report and review of the literature

FullText URL	fulltext.pdf
Author	Mitoma, Tomohiro\| Hayata, Kei\| Yokohata, Satomi\| Ohira, Akiko\| Kashino, Chiaki\| Kirino, Satoe\| Tani, Kazumasa\| Maki, Jota\| Eto, Eriko\| Masuyama, Hisashi\|
Keywords	Lupus Myometrium Placenta accreta spectrum Estrogen Uterine atony
Published Date	2022-07-02
Publication Title	BMC Pregnancy And Childbirth
Volume	volume22
Issue	issue1
Publisher	BMC
Start Page	535
ISSN	1471-2393
NCID	AA12035416
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	35780086
DOI	10.1186/s12884-022-04864-z
Web of Science KeyUT	000820223600001
Related Url	isVersionOf https://doi.org/10.1186/s12884-022-04864-z

The Combination of D-dimer and Glasgow Prognostic Score Can Be Useful in Predicting VTE in Patients with Stage IIIC and IVA Ovarian Cancer

JaLCDOI	10.18926/AMO/63406
FullText URL	76_2_129.pdf
Author	Kubo, Kotaro\| Nakamura, Keiichiro\| Okamoto, Kazuhiro\| Matsuoka, Hirofumi\| Ida, Naoyuki\| Haruma, Tomoko\| Ogawa, Chikako\| Masuyama, Hisashi\|
Abstract	Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann–Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC.
Keywords	D-dimer gynecologic cancer venous thromboembolism
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2022-04
Volume	volume76
Issue	issue2
Publisher	Okayama University Medical School
Start Page	129
End Page	135
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2022 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	35503440
Web of Science KeyUT	000792374900004

Non-Invasive Prenatal Genetic Testing (NIPT) Leading to Prenatal Diagnosis of Trisomy 21 Mosaicism and 18q Deletion Syndrome: Two Cases

JaLCDOI	10.18926/AMO/62816
FullText URL	75_6_745.pdf
Author	Hayata, Kei\| Mishima, Sakurako\| Ohira, Akiko\| Tani, Kazumasa\| Maki, Jota\| Eto, Eriko\| Ogawa, Chikako\| Masuyama, Hisashi\|
Abstract	NIPT is non-definitive testing to estimate the possibility that fetuses have trisomy 21, trisomy 18, or trisomy 13. However, in NIPT-positive and indeterminate cases, rare chromosomal disease may become apparent, requiring advanced genetic considerations and counseling skills. We experienced two such cases, a trisomy 21 mosaicism case triggered by NIPT-positive status and 18q deletion syndrome triggered by NIPT-indeterminate status. These cases have two clinical implications for NIPT. First, it was revealed that trisomy mosaicism might be found in NIPT-positive cases that have lower Z-Scores than those inferred from the fraction of fetal cfDNA in the case of standard trisomy. Second, it is possible that microdeletion syndrome could be the reason for an indeterminate NIPT result. Today’s genetic counseling requires more expertise in ethics and communication as well as genetic science because NIPT can lead to totally unexpected results.
Keywords	NIPT massively parallel sequencing trisomy 21 mosaicism 18q-deletion syndrome genetic counseling
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2021-12
Volume	volume75
Issue	issue6
Publisher	Okayama University Medical School
Start Page	745
End Page	750
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	34955544
Web of Science KeyUT	000735319800002
NAID	120007180276

EG-VEGF Induces Invasion of a Human Trophoblast Cell Line via PROKR2

JaLCDOI	10.18926/AMO/62806
FullText URL	75_6_677.pdf
Author	Tani Kazumasa\| Mitsui, Takashi\| Mishima, Sakurako\| Ohira, Akiko\| Maki, Jota\| Eto, Eriko\| Hayata, Kei\| Nakamura, Keiichiro\| Masuyama, Hisashi\|
Abstract	Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy.
Keywords	endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2021-12
Volume	volume75
Issue	issue6
Publisher	Okayama University Medical School
Start Page	677
End Page	684
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	34955534
Web of Science KeyUT	000735297900002
NAID	120007180286