Fujiwara, Tomohiro - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Real‐World Data of Comprehensive Cancer Genomic Profiling Tests Performed in the Routine Clinical Setting in Sarcoma

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Author	Nakata, Eiji\| Ennishi, Daisuke\| Osone, Tatsunori\| Ninomiya, Kiichiro\| Tomida, Shuta\| Itano, Takuto\| Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Ida, Naoyuki\| Yamamoto, Hideki\| Futagawa, Mashu\| Shimoi, Tatsunori\| Yanai, Hiroyuki\| Hirasawa, Akira\| Toyooka, Shinichi\| Tabata, Masahiro\| Ozaki, Toshifumi\|
Keywords	comprehensive genomic profiling genotype-matched therapy multiplex gene panel test sarcoma
Published Date	2025-08
Publication Title	Cancer Medicine
Volume	volume14
Issue	issue15
Publisher	Wiley
Start Page	e71098
ISSN	2045-7634
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	40755265
DOI	10.1002/cam4.71098
Web of Science KeyUT	001543086300001
Related Url	isVersionOf https://doi.org/10.1002/cam4.71098

Advances in liquid biopsy for bone and soft-tissue sarcomas

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Author	Wang, Yilang\| Fujiwara, Tomohiro\| Kurozumi, Takanao\| Ando, Teruhiko\| Ishimaru, Takahiko\| Kondo, Hiroya\| Nakata, Eiji\| Kunisada, Toshiyuki\| Ozaki, Toshifumi\|
Keywords	Liquid biopsy Bone sarcoma Soft-tissue sarcoma Circulating tumor cells Circulating nucleic acids Circulating microvesicles
Note	The version of record of this article, first published in International Journal of Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10147-025-02813-2\|
Published Date	2025-07-18
Publication Title	International Journal of Clinical Oncology
Publisher	Springer Science and Business Media LLC
ISSN	1341-9625
NCID	AA11086579
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40679665
DOI	10.1007/s10147-025-02813-2
Web of Science KeyUT	001531083300001
Related Url	isVersionOf https://doi.org/10.1007/s10147-025-02813-2

A Characteristic Magnetic Resonance Imaging Finding to Identify Morton Neuroma: The Slug Sign

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Author	Horita, Masahiro\| Saiga, Kenta\| Fujiwara, Tomohiro\| Nakata, Eiji\| Ozaki, Toshifumi\|
Keywords	Morton neuroma T1-weighted MRI forefoot pain slug sign
Published Date	2024-08-26
Publication Title	Foot & Ankle Orthopaedics
Volume	volume9
Issue	issue3
Publisher	SAGE Publications
ISSN	2473-0114
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	39193453
DOI	10.1177/24730114241268285
Related Url	isVersionOf https://doi.org/10.1177/24730114241268285

Osteosarcoma cell-derived CCL2 facilitates lung metastasis via accumulation of tumor-associated macrophages

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Author	Kondo, Hiroya\| Tazawa, Hiroshi\| Fujiwara, Tomohiro\| Yoshida, Aki\| Kure, Miho\| Demiya, Koji\| Kanaya, Nobuhiko\| Hata, Toshiaki\| Uotani, Koji\| Hasei, Joe\| Kunisada, Toshiyuki\| Kagawa, Shunsuke\| Yoshioka, Yusuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Keywords	Osteosarcoma Lung metastasis Tumor-associated macrophage CCL2 Extracellular vesicle
Note	The version of record of this article, first published in Cancer Immunology, Immunotherapy, is available online at Publisher’s website: http://dx.doi.org/10.1007/s00262-025-04051-x\|
Published Date	2025-05-09
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume74
Issue	issue7
Publisher	Springer
Start Page	193
ISSN	0340-7004
NCID	AA00598499
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	40343498
DOI	10.1007/s00262-025-04051-x
Web of Science KeyUT	001485530100002
Related Url	isVersionOf https://doi.org/10.1007/s00262-025-04051-x

Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy

Author	Ninomiya, Toshifumi\| Kemmotsu, Naoya\| Mukohara, Fumiaki\| Magari, Masaki\| Miyamoto, Ai\| Ueda, Youki\| Ishino, Takamasa\| Nagasaki, Joji\| Fujiwara, Tomohiro\| Yamamoto, Hidetaka\| Hayashi, Hidetoshi\| Tachibana, Kota\| Ishida, Joji\| Otani, Yoshihiro\| Tanaka, Shota\| Toyooka, Shinichi\| Okamoto, Isamu\| Togashi, Yosuke\|
Note	This is an Accepted Manuscript of an article published by American Association for Cancer Research (AACR).\| This fulltext file will be available in Mar. 2026.\|
Published Date	2025-03-14
Publication Title	Cancer Research
Volume	volume85
Issue	issue6
Publisher	American Association for Cancer Research (AACR)
Start Page	1082
End Page	1096
ISSN	0008-5472
NCID	AA00598557
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	©2025 American Association for Cancer Research
File Version	author
PubMed ID	39804971
DOI	10.1158/0008-5472.can-24-2274
Web of Science KeyUT	001444866400013
Related Url	isVersionOf https://doi.org/10.1158/0008-5472.can-24-2274

Empowering pediatric, adolescent, and young adult patients with cancer utilizing generative AI chatbots to reduce psychological burden and enhance treatment engagement: a pilot study

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Author	Hasei, Joe\| Hanzawa, Mana\| Nagano, Akihito\| Maeda, Naoko\| Yoshida, Shinichirou\| Endo, Makoto\| Yokoyama, Nobuhiko\| Ochi, Motoharu\| Ishida, Hisashi\| Katayama, Hideki\| Fujiwara, Tomohiro\| Nakata, Eiji\| Nakahara, Ryuichi\| Kunisada, Toshiyuki\| Tsukahara, Hirokazu\| Ozaki, Toshifumi\|
Keywords	generative AI chatbot large language model pediatric cancer adolescent and young adult (AYA) psychological support
Published Date	2025-02-25
Publication Title	Frontiers in Digital Health
Volume	volume7
Publisher	Frontiers Media
Start Page	1543543
ISSN	2673-253X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 Hasei, Hanzawa, Nagano, Maeda, Yoshida, Endo, Yokoyama, Ochi, Ishida, Katayama, Fujiwara, Nakata, Nakahara, Kunisada, Tsukahara and Ozaki.
File Version	publisher
PubMed ID	40070545
DOI	10.3389/fdgth.2025.1543543
Web of Science KeyUT	001441098700001
Related Url	isVersionOf https://doi.org/10.3389/fdgth.2025.1543543

Radiographic and Clinical Assessment of Unidirectional Porous Beta-Tricalcium Phosphate to Treat Benign Bone Tumors

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Author	Kunisada, Toshiyuki\| Nakata, Eiji\| Fujiwara, Tomohiro\| Katayama, Haruyoshi\| Itano, Takuto\| Kurozumi, Takanao\| Ando, Teruhiko\| Ozaki, Toshifumi\|
Keywords	unidirectional porous beta-tricalcium phosphate bone tumor bone graft radiography bone remodeling
Published Date	2025-02-10
Publication Title	Biomimetics
Volume	volume10
Issue	issue2
Publisher	MDPI
Start Page	101
ISSN	2313-7673
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	39997124
DOI	10.3390/biomimetics10020101
Web of Science KeyUT	001430456900001
Related Url	isVersionOf https://doi.org/10.3390/biomimetics10020101

The Three-Class Annotation Method Improves the AI Detection of Early-Stage Osteosarcoma on Plain Radiographs: A Novel Approach for Rare Cancer Diagnosis

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Author	Hasei, Joe\| Nakahara, Ryuichi\| Otsuka, Yujiro\| Nakamura, Yusuke\| Ikuta, Kunihiro\| Osaki, Shuhei\| Hironari, Tamiya\| Miwa, Shinji\| Ohshika, Shusa\| Nishimura, Shunji\| Kahara, Naoaki\| Yoshida, Aki\| Fujiwara, Tomohiro\| Nakata, Eiji\| Kunisada, Toshiyuki\| Ozaki, Toshifumi\|
Keywords	osteosarcoma medical image annotation anatomical annotation method rare cancer
Published Date	2024-12-25
Publication Title	Cancers
Volume	volume17
Issue	issue1
Publisher	MDPI
Start Page	29
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by the authors.
File Version	publisher
PubMed ID	39796660
DOI	10.3390/cancers17010029
Web of Science KeyUT	001393409100001
Related Url	isVersionOf https://doi.org/10.3390/cancers17010029

Identification of ENO-1 positive extracellular vesicles as a circulating biomarker for monitoring of Ewing sarcoma

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Author	Uotani, Koji\| Fujiwara, Tomohiro\| Ueda, Koji\| Yoshida, Aki\| Iwata, Shintaro\| Morita, Takuya\| Kiyono, Masahiro\| Kunisada, Toshiyuki\| Takeda, Ken\| Hasei, Joe\| Yoshioka, Yusuke\| Ochiya, Takahiro\| Ozaki, Toshifumi\|
Keywords	circulating biomarker Ewing sarcoma extracellular vesicles liquid biopsy proteome
Published Date	2024-09-22
Publication Title	Cancer Science
Volume	volume115
Issue	issue11
Publisher	Wiley
Start Page	3660
End Page	3671
ISSN	1347-9032
NCID	AA11808050
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Author(s).
File Version	publisher
PubMed ID	39307979
DOI	10.1111/cas.16343
Web of Science KeyUT	001318444100001
Related Url	isVersionOf https://doi.org/10.1111/cas.16343

High-quality expert annotations enhance artificial intelligence model accuracy for osteosarcoma X-ray diagnosis

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Author	Hasei, Joe\| Nakahara, Ryuichi\| Otsuka, Yujiro\| Nakamura, Yusuke\| Hironari, Tamiya\| Kahara, Naoaki\| Miwa, Shinji\| Ohshika, Shusa\| Nishimura, Shunji\| Ikuta, Kunihiro\| Osaki, Shuhei\| Yoshida, Aki\| Fujiwara, Tomohiro\| Nakata, Eiji\| Kunisada, Toshiyuki\| Ozaki, Toshifumi\|
Keywords	artificial intelligence clinical decision support diagnostic imaging image annotation osteosarcoma detection
Published Date	2024-09-02
Publication Title	Cancer Science
Volume	volume115
Issue	issue11
Publisher	Wiley
Start Page	3695
End Page	3704
ISSN	1347-9032
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Author(s).
File Version	publisher
PubMed ID	39223070
DOI	10.1111/cas.16330
Web of Science KeyUT	001302420900001
Related Url	isVersionOf https://doi.org/10.1111/cas.16330

Utilizing the Metaverse to Provide Innovative Psychosocial Support for Pediatric, Adolescent, and Young Adult Patients with Rare Cancer

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Author	Hasei, Joe\| Ishida, Hisashi\| Katayama, Hideki\| Maeda, Naoko\| Nagano, Akihito\| Ochi, Motoharu\| Okamura, Masako\| Iwata, Shintaro\| Ikuta, Kunihiro\| Yoshida, Shinichirou\| Fujiwara, Tomohiro\| Nakata, Eiji\| Nakahara, Ryuichi\| Kunisada, Toshiyuki\| Ozaki, Toshifumi\|
Keywords	virtual reality metaverse adolescent and young adult rare cancer mental health
Published Date	2024-07-23
Publication Title	Cancers
Volume	volume16
Issue	issue15
Publisher	MDPI
Start Page	2617
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by the authors.
File Version	publisher
PubMed ID	39123345
DOI	10.3390/cancers16152617
Web of Science KeyUT	001287028100001
Related Url	isVersionOf https://doi.org/10.3390/cancers16152617

Clinical Application of Unidirectional Porous Hydroxyapatite to Bone Tumor Surgery and Other Orthopedic Surgery

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Author	Kunisada, Toshiyuki\| Nakata, Eiji\| Fujiwara, Tomohiro\| Hata, Toshiaki\| Sato, Kohei\| Katayama, Haruyoshi\| Kondo, Ayana\| Ozaki, Toshifumi\|
Keywords	hydroxyapatite bone tumor orthopedic surgery unidirectional porous hydroxyapatite bone graft
Published Date	2024-05-15
Publication Title	Biomimetics
Volume	volume9
Issue	issue5
Publisher	MDPI
Start Page	294
ISSN	2313-7673
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by the authors.
File Version	publisher
PubMed ID	38786504
DOI	10.3390/biomimetics9050294
Web of Science KeyUT	001232206900001
Related Url	isVersionOf https://doi.org/10.3390/biomimetics9050294

Fluorescence-guided assessment of bone and soft-tissue sarcomas for predicting the efficacy of telomerase-specific oncolytic adenovirus

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Author	Uotani, Koji\| Tazawa, Hiroshi\| Hasei, Joe\| Fujiwara, Tomohiro\| Yoshida, Aki\| Yamakawa, Yasuaki\| Omori, Toshinori\| Sugiu, Kazuhisa\| Komatsubara, Tadashi\| Kondo, Hiroya\| Morita, Takuya\| Kiyono, Masahiro\| Yokoo, Suguru\| Hata, Toshiaki\| Kunisada, Toshiyuki\| Takeda, Ken\| Urata, Yasuo\| Fujiwara, Toshiyoshi\| Ozaki, Toshifumi\|
Published Date	2024-02-20
Publication Title	PLoS ONE
Volume	volume19
Issue	issue2
Publisher	Public Library of Science
Start Page	e0298292
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 Uotani et al.
File Version	publisher
PubMed ID	38377118
DOI	10.1371/journal.pone.0298292
Web of Science KeyUT	001176939600021
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0298292

p53-Armed Oncolytic Virotherapy Improves Radiosensitivity in Soft-Tissue Sarcoma by Suppressing BCL-xL Expression

JaLCDOI	10.18926/AMO/66924
FullText URL	78_2_151.pdf
Author	Komatsubara, Tadashi\| Tazawa, Hiroshi\| Hasei, Joe\| Omori, Toshinori\| Sugiu, Kazuhisa\| Mochizuki, Yusuke\| Demiya, Koji\| Yoshida, Aki\| Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Urata, Yasuo\| Kagawa, Shunsuke\| Ozaki, Toshifumi\| Fujiwara, Toshiyoshi\|
Abstract	Soft-tissue sarcoma (STS) is a heterogeneous group of rare tumors originating predominantly from the embryonic mesoderm. Despite the development of combined modalities including radiotherapy, STSs are often refractory to antitumor modalities, and novel strategies that improve the prognosis of STS patients are needed. We previously demonstrated the therapeutic potential of two telomerase-specific replication-competent oncolytic adenoviruses, OBP-301 and tumor suppressor p53-armed OBP-702, in human STS cells. Here, we demonstrate in vitro and in vivo antitumor effects of OBP-702 in combination with ionizing radiation against human STS cells (HT1080, NMS-2, SYO-1). OBP-702 synergistically promoted the antitumor effect of ionizing radiation in the STS cells by suppressing the expression of B-cell lymphoma-X large (BCL-xL) and enhancing ionizing radiation-induced apoptosis. The in vivo experiments demonstrated that this combination therapy significantly suppressed STS tumors’ growth. Our results suggest that OBP-702 is a promising antitumor reagent for promoting the radiosensitivity of STS tumors.
Keywords	soft-tissue sarcoma radiotherapy oncolytic adenovirus p53 BCL-xL
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2024-04
Volume	volume78
Issue	issue2
Publisher	Okayama University Medical School
Start Page	151
End Page	161
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2024 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	38688833
Web of Science KeyUT	001229151800007

Advances in treatment of alveolar soft part sarcoma: an updated review

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Author	Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Nakata, Eiji\| Nishida, Kenji\| Yanai, Hiroyuki\| Nakamura, Tomoki\| Tanaka, Kazuhiro\| Ozaki, Toshifumi\|
Keywords	alveolar soft part sarcoma surgery chemotherapy targeted therapy immunotherapy
Published Date	2023-08-25
Publication Title	Japanese Journal of Clinical Oncology
Volume	volume53
Issue	issue11
Publisher	Oxford University Press (OUP)
Start Page	1009
End Page	1018
ISSN	1465-3621
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023.
File Version	publisher
PubMed ID	37626447
DOI	10.1093/jjco/hyad102
Web of Science KeyUT	001080372000001
Related Url	isVersionOf https://doi.org/10.1093/jjco/hyad102

PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours

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Author	Takihira, Shota\| Yamada, Daisuke\| Osone, Tatsunori\| Takao, Tomoka\| Sakaguchi, Masakiyo\| Hakozaki, Michiyuki\| Itano, Takuto\| Nakata, Eiji\| Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Ozaki, Toshifumi\| Takarada, Takeshi\|
Note	The version of record of this article, first published in British Journal of Cancer, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41416-024-02632-8\|
Published Date	2024-03-06
Publication Title	British Journal of Cancer
Volume	volume130
Issue	issue9
Publisher	Springer Science and Business Media LLC
Start Page	1493
End Page	1504
ISSN	0007-0920
NCID	AA00574355
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	38448751
DOI	10.1038/s41416-024-02632-8
Web of Science KeyUT	001180796100003
Related Url	isVersionOf https://doi.org/10.1038/s41416-024-02632-8

Inhibitory Effect of a Tankyrase Inhibitor on Mechanical Stress-Induced Protease Expression in Human Articular Chondrocytes

FullText URL	fulltext.pdf
Author	Hotta, Yoshifumi\| Nishida, Keiichiro\| Yoshida, Aki\| Nasu, Yoshihisa\| Nakahara, Ryuichi\| Naniwa, Shuichi\| Shimizu, Noriyuki\| Ichikawa, Chinatsu\| Lin, Deting\| Fujiwara, Tomohiro\| Ozaki, Toshifumi\|
Keywords	osteoarthritis chondrocyte mechanical stress tankyrases XAV939 SOX9 ADAMTS-5 MMP-13 IL-1β NF-κB β-catenin
Published Date	2024-01-24
Publication Title	International Journal of Molecular Sciences
Volume	volume25
Issue	issue3
Publisher	MDPI
Start Page	1443
ISSN	1661-6596
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 by the authors.
File Version	publisher
PubMed ID	38338721
DOI	10.3390/ijms25031443
Web of Science KeyUT	001161430700001
Related Url	isVersionOf https://doi.org/10.3390/ijms25031443

Role of catecholamine synthases in the maintenance of cancer stem-like cells in malignant peripheral nerve sheath tumors

FullText URL	fulltext.pdf
Author	Katayama, Haruyoshi\| Fujimura, Atsushi\| Huang, Rongsheng\| Otani, Yusuke\| Itano, Takuto\| Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Nakata, Eiji\| Ozaki, Toshifumi\|
Keywords	benserazide cancer stem cell catecholamine synthase malignant peripheral nerve sheath tumor Schwann cell vesicular monoamine transporter
Published Date	2024-01-26
Publication Title	Cancer Science
Volume	volume115
Issue	issue3
Publisher	Wiley
Start Page	871
End Page	882
ISSN	1347-9032
NCID	AA11808050
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Authors.
File Version	publisher
PubMed ID	38279513
DOI	10.1111/cas.16077
Web of Science KeyUT	001149722500001
Related Url	isVersionOf https://doi.org/10.1111/cas.16077

Effect of bacterium in the malignant wounds of soft tissue sarcoma

FullText URL	fulltext.pdf
Author	Nakata, Eiji\| Fujiwara, Tomohiro\| Katayama, Haruyoshi\| Itano, Takuto\| Kunisada, Toshiyuki\| Ozaki, Toshifumi\|
Keywords	malignant wounds soft tissue sarcoma microbiological analysis surgical site infection prognosis
Published Date	2022-08-17
Publication Title	Oncology Letters
Volume	volume24
Issue	issue4
Publisher	Spandidos Publications
Start Page	345
ISSN	1792-1074
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Nakata et al.
File Version	publisher
PubMed ID	36072006
DOI	10.3892/ol.2022.13465
Web of Science KeyUT	000891420600001
Related Url	isVersionOf https://doi.org/10.3892/ol.2022.13465

Clinicopathological and histological analysis of secondary malignant giant cell tumors of bone without radiotherapy

FullText URL	fulltext.pdf
Author	Nakata, Eiji\| Kawai, Hotaka\| Fujiwara, Tomohiro\| Kunisada, Toshiyuki\| Inoue, Hirofumi\| Futagawa, Mashu\| Katayama, Haruyoshi\| Itano, Takuto\| Ozaki, Toshifumi\|
Keywords	giant cell tumor of bone malignant transformation p53 denosumab molecular targeted therapy
Published Date	2022-07-19
Publication Title	Oncology Letters
Volume	volume24
Issue	issue3
Publisher	Spandidos Publications
Start Page	319
ISSN	1792-1074
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Nakata et al.
File Version	publisher
PubMed ID	35949597
DOI	10.3892/ol.2022.13439
Web of Science KeyUT	000840512400001
Related Url	isVersionOf https://doi.org/10.3892/ol.2022.13439