| ID | 70007 |
| Author |
Hanaya, Tadashi
Department of Chemistry, Faculty of Science, Okayama University
Kaken ID
publons
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Maeda, Yuta
Department of Chemistry, Faculty of Science, Okayama University
Ejiri, Kazumasa
Department of Chemistry, Faculty of Science, Okayama University
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| Abstract | The first total synthesis and structural identification of cyanopterin, a pterin glycoside isolated from the cyanobacterium Synechocystis sp. PCC 6803, has been accomplished. The synthesis was achieved by convergent coupling of three key derivatives: d-glucuronate, d-galactose, and 6-hydroxymethylpterin. An α-selective glycosylation enabled efficient construction of the glucuronate–galactose disaccharide, while subsequent β-exclusive glycosylation with the 6-hydroxymethylpterin derivative furnished the desired pterin–disaccharide glycoside. Final deprotection provided cyanopterin in its natural form, allowing confirmation of its precise structure.
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| Keywords | Pterin glycoside
6-Hydroxymethylpterin
Structural identification
Glycosylation
Cyanopterin
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| Note | © 2025 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/
This fulltext file will be available in Oct. 2027.
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| Published Date | 2025-12
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| Publication Title |
Carbohydrate Research
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| Volume | volume558
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| Publisher | Elsevier BV
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| Start Page | 109710
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| ISSN | 0008-6215
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| NCID | AA00598932
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| Content Type |
Journal Article
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| language |
English
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| OAI-PMH Set |
岡山大学
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| Copyright Holders | © 2025 Elsevier Ltd.
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| File Version | author
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| PubMed ID | |
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| Web of Science KeyUT | |
| Related Url | isVersionOf https://doi.org/10.1016/j.carres.2025.109710
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| License | https://creativecommons.org/licenses/by-nc-nd/4.0/
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