| FullText URL | fulltext.pdf |
|---|---|
| Author | Ogawa, Toshihiro| Kikuchi, Satoru| Tabuchi, Motoyasu| Mitsui, Ema| Une, Yuta| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Ohara, Toshiaki| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Published Date | 2022-06-16 |
| Publication Title | Molecular Therapy-Oncolytics |
| Volume | volume25 |
| Publisher | Cell Press |
| Start Page | 249 |
| End Page | 261 |
| ISSN | 2372-7705 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Author(s). |
| File Version | publisher |
| PubMed ID | 35615263 |
| DOI | 10.1016/j.omto.2022.04.009 |
| Web of Science KeyUT | 000800437000008 |
| Related Url | isVersionOf https://doi.org/10.1016/j.omto.2022.04.009 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Tazawa, Hiroshi| Shigeyasu, Kunitoshi| Noma, Kazuhiro| Kagawa, Shunsuke| Sakurai, Fuminori| Mizuguchi, Hiroyuki| Kobayashi, Hisataka| Imamura, Takeshi| Fujiwara, Toshiyoshi| |
| Keywords | adenovirus EMT survivin telomerase vimentin |
| Published Date | 2022-04-09 |
| Publication Title | Cancer Science |
| Publisher | Wiley |
| ISSN | 1347-9032 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2022 The Authors. |
| File Version | publisher |
| PubMed ID | 35398956 |
| DOI | 10.1111/cas.15369 |
| Web of Science KeyUT | 000783300600001 |
| Related Url | isVersionOf https://doi.org/10.1111/cas.15369 |
| JaLCDOI | 10.18926/AMO/63425 |
|---|---|
| FullText URL | 76_2_203.pdf |
| Author | Masuda, Tomoya| Tazawa, Hiroshi| Hashimoto, Yuuri| Ieda, Takeshi| Kikuchi, Satoru| Kuroda, Shinji| Noma, Kazuhiro| Urata, Yasuo| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | The epithelial-mesenchymal transition (EMT), a normal biological process by which epithelial cells acquire a mesenchymal phenotype, is associated with migration, metastasis, and chemoresistance in cancer cells, and with poor prognosis in patients with esophageal cancer. However, therapeutic strategies to inhibit EMT in tumor environments remain elusive. Here, we show the therapeutic potential of telomerase-specific replication- competent oncolytic adenovirus OBP-301 in human esophageal cancer TE4 and TE6 cells with an EMT phenotype. Transforming growth factor-β (TGF-β) administration induced the EMT phenotype with spindleshaped morphology, upregulation of mesenchymal markers and EMT transcription factors, migration, and chemoresistance in TE4 and TE6 cells. OBP-301 significantly inhibited the EMT phenotype via E1 accumulation. EMT cancer cells were susceptible to OBP-301 via massive autophagy induction. OBP-301 suppressed tumor growth and lymph node metastasis of TE4 cells co-inoculated with TGF-β-secreting fibroblasts. Our results suggest that OBP-301 inhibits the TGF-β-induced EMT phenotype in human esophageal cancer cells. OBP-301-mediated E1A overexpression is a promising antitumor strategy to inhibit EMT-mediated esophageal cancer progression. |
| Keywords | esophageal cancer EMT TGF-β oncolytic adenovirus E1A |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2022-04 |
| Volume | volume76 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 203 |
| End Page | 215 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2022 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 35503449 |
| Web of Science KeyUT | 000792291900003 |
| FullText URL | fulltext20220131-2.pdf |
|---|---|
| Author | Kanaya, Nobuhiko| Kuroda, Shinji| Kakiuchi, Yoshihiko| Takeda, Sho| Kikuchi, Satoru| Noma, Kazuhiro| Yoshida, Ryuichi| Umeda, Yuzo| Teraishi, Fuminori| Nishizaki, Masahiko| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | Gastric cancer D2 lymphadenectomy Suprapancreatic lymphadenectomy Posterior hepatic plexus Distal gastrectomy |
| Note | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00423-022-02437-4| |
| Published Date | 2022-1-12 |
| Publication Title | Langenbeck's Archives of Surgery |
| Volume | volume407 |
| Issue | issue2 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 871 |
| End Page | 877 |
| ISSN | 1435-2443 |
| NCID | AA11211080 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022 |
| File Version | author |
| PubMed ID | 35022835 |
| DOI | 10.1007/s00423-022-02437-4 |
| Web of Science KeyUT | 000741939500003 |
| Related Url | isVersionOf https://doi.org/10.1007/s00423-022-02437-4 |
| JaLCDOI | 10.18926/AMO/62818 |
|---|---|
| FullText URL | 75_6_755.pdf |
| Author | Takagi, Kosei| Kuise, Takashi| Umeda, Yuzo| Yoshida, Ryuichi| Yoshida, Kazuhiro| Nagai, Yasuo| Noma, Kazuhiro| Tanabe, Shunsuke| Maeda, Naoaki| Yagi, Takahito| Fujiwara, Toshiyoshi| |
| Abstract | Approximately 4% of patients with esophageal cancer develop a second primary malignancy in the upper gastrointestinal trunk. However, hepatectomy following esophagectomy for esophageal cancer has rarely been reported. We report the case of a 70-year-old man who underwent an esophagectomy for esophageal cancer with retrosternal gastric tube reconstruction. Nine years later, he developed hepatocellular carcinoma with tumor thrombus involving the left portal vein, and was successfully treated with left hemihepatectomy. Special attention should be paid to avoiding incidental injury of the gastric tube as well as the right gastroepiploic artery during the hepatectomy. |
| Keywords | liver resection, esophagectomy, retrosternal gastric tube reconstruction |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2021-12 |
| Volume | volume75 |
| Issue | issue6 |
| Publisher | Okayama University Medical School |
| Start Page | 755 |
| End Page | 758 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2021 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 34955546 |
| Web of Science KeyUT | 000735319800004 |
| NAID | 120007180274 |
| FullText URL | fulltext20210831-3.pdf |
|---|---|
| Author | Shirakawa, Yasuhiro| Tazawa, Hiroshi| Tanabe, Shunsuke| Kanaya, Nobuhiko| Noma, Kazuhiro| Koujima, Takeshi| Kashima, Hajime| Kato, Takuya| Kuroda, Shinji| Kikuchi, Satoru| Kagawa, Shunsuke| Katsui, Kuniaki| Kanazawa, Susumu| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Keywords | Telomerase adenovirus radiotherapy esophageal cancer immunotherapy |
| Note | © 2021 Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at [https://doi.org/10.1016/j.ejca.2021.04.043] .| |
| Published Date | 2021-8 |
| Publication Title | European Journal of Cancer |
| Volume | volume153 |
| Publisher | Elsevier BV |
| Start Page | 98 |
| End Page | 108 |
| ISSN | 0959-8049 |
| NCID | AA1075407X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Elsevier Ltd. |
| File Version | author |
| PubMed ID | 34153720 |
| DOI | 10.1016/j.ejca.2021.04.043 |
| Web of Science KeyUT | 000686051300013 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ejca.2021.04.043 |
| FullText URL | fulltext20210607-4.pdf table1-20210607-4.pdf table2-20210607-4.pdf figure-20210607-4.pdf |
|---|---|
| Author | Kikuchi, Satoru| Kagawa, Tetsuya| Kuroda, Shinji| Nishizaki, Masahiko| Takata, Nobuo| Kuwada, Kazuya| Shoji, Ryohei| Kakiuchi, Yoshihiko| Mitsuhashi, Toshiharu| Umeda, Yuzo| Noma, Kazuhiro| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Keywords | Endoscopic surgical skill quantification system Qualified surgeon Laparoscopic distal gastrectomy Gastric cancer Cumulative sum analysis |
| Note | This is a post-peer-review, pre-copyedit version of an article published in [Surgery Today]. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00595-021-02309-2| |
| Published Date | 2021-5-29 |
| Publication Title | Surgery Today |
| Volume | volume51 |
| Publisher | Springer Science and Business Media LLC |
| Start Page | 1978 |
| End Page | 1984 |
| ISSN | 0941-1291 |
| NCID | AA10824685 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © Springer Nature Singapore Pte Ltd. 2021 |
| File Version | author |
| PubMed ID | 34050804 |
| DOI | 10.1007/s00595-021-02309-2 |
| Web of Science KeyUT | 000655944300001 |
| Related Url | isVersionOf https://doi.org/10.1007/s00595-021-02309-2 |
| FullText URL | fulltext20210608.pdf |
|---|---|
| Author | Umeda, Hibiki| Kikuchi, Satoru| Kuroda, Shinji| Yano, Shuya| Tanaka, Takehiro| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Umeda, Yuzo| Fujiwara, Toshiyoshi| |
| Keywords | Gastric yolk sac Tumor-like carcinoma Adenocarcinoma Alpha-fetoprotein |
| Published Date | 2021-05-06 |
| Publication Title | Surgical Case Reports |
| Volume | volume7 |
| Issue | issue1 |
| Publisher | Springer |
| Start Page | 111 |
| ISSN | 2198-7793 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021. |
| File Version | publisher |
| PubMed ID | 33956241 |
| DOI | 10.1186/s40792-021-01199-3 |
| NAID | 120007045008 |
| Web of Science KeyUT | 000656467700001 |
| Related Url | isVersionOf https://doi.org/10.1186/s40792-021-01199-3 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Katsube, Ryoichi| Noma, Kazuhiro| Ohara, Toshiaki| Nishiwaki, Noriyuki| Kobayashi, Teruki| Komoto, Satoshi| Sato, Hiroaki| Kashima, Hajime| Kato, Takuya| Kikuchi, Satoru| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kobayashi, Hisataka| Fujiwara, Toshiyoshi| |
| Published Date | 2021-01-18 |
| Publication Title | Scientific Reports |
| Volume | volume11 |
| Issue | issue1 |
| Publisher | Nature Research |
| Start Page | 1693 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2021 |
| File Version | publisher |
| PubMed ID | 33462372 |
| DOI | 10.1038/s41598-021-81465-4 |
| Web of Science KeyUT | 000612156600008 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-021-81465-4 |
| FullText URL | fulltext.pdf Figures.pdf Suppl_Material_Methods.pdf Suppl_Figures.pdf Legend_suppl_figures.pdf Suppl_Table.pdf |
|---|---|
| Author | Kajioka, Hiroki| Kagawa, Shunsuke| Ito, Atene| Yoshimoto, Masashi| Sakamoto, Shuichi| Kikuchi, Satoru| Kuroda, Shinji| Yoshida, Ryuichi| Umeda, Yuzo| Noma, Kazuhiro| Tazawa, Hiroshi| Fujiwara, Toshiyoshi| |
| Keywords | HMGB1 Epithelial to mesenchymal transition Phorbol 12-myristate 13-acetate Ischemia-reperfusion model |
| Note | This fulltext is available in January, 2022.| |
| Published Date | 2021-01-28 |
| Publication Title | Cancer Letters |
| Volume | volume497 |
| Publisher | Elsevier |
| Start Page | 1 |
| End Page | 3 |
| ISSN | 0304-3835 |
| NCID | AA00598513 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 33065249 |
| DOI | 10.1016/j.canlet.2020.10.015 |
| Web of Science KeyUT | 000596072900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.canlet.2020.10.015 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Ishikawa, Wataru| Kikuchi, Satoru| Ogawa, Toshihiro| Tabuchi, Motoyasu| Tazawa, Hiroshi| Kuroda, Shinji| Noma, Kazuhiro| Nishizaki, Masahiko| Kagawa, Shunsuke| Urata, Yasuo| Fujiwara, Toshiyoshi| |
| Keywords | peritoneal metastasis adenovirus gastric cancer intraperitoneal chemotherapy paclitaxel oncolytic virus |
| Published Date | 2020-09-25 |
| Publication Title | Molecular Therapy - Oncolytics |
| Volume | volume18 |
| Publisher | Cell Press |
| Start Page | 262 |
| End Page | 271 |
| ISSN | 2372-7705 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Author(s). |
| File Version | publisher |
| PubMed ID | 32728614 |
| DOI | 10.1016/j.omto.2020.06.021 |
| Web of Science KeyUT | 000575168700023 |
| Related Url | isVersionOf https://doi.org/10.1016/j.omto.2020.06.021 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Maeda, Naoaki| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Sakurama, Kazufumi| Noma, Kazuhiro| Fujiwara, Toshiyoshi| |
| Published Date | 2020-06-26 |
| Publication Title | World Journal of Surgical Oncology |
| Volume | volume18 |
| Issue | issue1 |
| Publisher | BMC |
| Start Page | 143 |
| ISSN | 1477-7819 |
| NCID | AA12048269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s). 2020 |
| File Version | publisher |
| PubMed ID | 32591002 |
| DOI | 10.1186/s12957-020-01908-6 |
| Web of Science KeyUT | 000545948700003 |
| Related Url | isVersionOf https://doi.org/10.1186/s12957-020-01908-6 |
| JaLCDOI | 10.18926/AMO/57946 |
|---|---|
| FullText URL | 74_1_1.pdf |
| Author | Chen, Yuehua| Ohara, Toshiaki| Xing, Boyi| Qi, Jiping| Noma, Kazuhiro| Matsukawa, Akihiro| |
| Abstract | Iron is a trace but vital element in the human body and is necessary for a multitude of crucial processes in life. However, iron overload is known to induce carcinogenesis via oxidative stress. Cancer cells require large amounts of iron for their rapid division and cell growth. Iron was recently found to play a role in cancer stem cells (CSCs); it maintains stemness during development. Iron also plays an important role in stemness by moderating reactive oxygen species. Thus, iron metabolism in CSCs is a promising therapeutic target. In this review, we summarize the roles of iron in cancer cells and CSCs. We also summarize anti-cancer therapeutic studies with iron chelators and describe our expectation of a new therapeutic strategy for CSCs on the basis of our findings. |
| Keywords | cancer stem cell stemness iron chelation chemotherapy |
| Amo Type | Review |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 1 |
| End Page | 6 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099242 |
| Web of Science KeyUT | 000516606200001 |
| NAID | 120006795613 |
| Author | Ieda, Takeshi| Tazawa, Hiroshi| Okabayashi, Hiroki| Yano, Shuya| Shigeyasu, Kunitoshi| Kuroda, Shinji| Ohara, Toshiaki| Noma, Kazuhiro| Kishimoto, Hiroyuki| Nishizaki, Masahiko| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Saitou, Takashi| Imamura, Takeshi| Fujiwara, Toshiyoshi| |
|---|---|
| Published Date | 2019-11-8 |
| Publication Title | Scientific Reports |
| Volume | volume9 |
| Publisher | Nature Publishing Group |
| Start Page | 16378 |
| ISSN | 2045-2322 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © The Author(s) 2019 |
| File Version | publisher |
| PubMed ID | 31705021 |
| DOI | 10.1038/s41598-019-52816-z |
| Web of Science KeyUT | 000495372900001 |
| Related Url | isVersionOf https://doi.org/10.1038/s41598-019-52816-z |
| FullText URL | cancers_11_2_177.pdf |
|---|---|
| Author | Katsura, Yuki| Ohara, Toshiaki| Noma, Kazuhiro| Ninomiya, Takayuki| Kashima, Hajime| Kato, Takuya| Sato, Hiroaki| Komoto, Satoshi| Narusaka, Toru| Tomono, Yasuko| Xing, Boyi| Chen, Yuehua| Tazawa, Hiroshi| Kagawa, Shunsuke| Shirakawa, Yasuhiro| Kasai , Tomonari| Seno, Masaharu| Matsukawa, Akihiro| Fujiwara, Toshiyoshi| |
| Keywords | cancer stem cells combination therapy iron stemness |
| Published Date | 2019-02-03 |
| Publication Title | Cancers |
| Volume | volume11 |
| Issue | issue2 |
| Publisher | MDPI |
| Start Page | 177 |
| ISSN | 2072-6694 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 by the authors |
| File Version | publisher |
| PubMed ID | 30717462 |
| DOI | 10.3390/cancers11020177 |
| Web of Science KeyUT | 000460747200051 |
| Related Url | isVersionOf https://doi.org/10.3390/cancers11020177 |
| JaLCDOI | 10.18926/AMO/54981 |
|---|---|
| FullText URL | 71_2_127.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Tanabe, Shunsuke| Kuroda, Shinji| Kagawa, Shunsuke| Katsui, Kuniaki| Katayama, Norihisa| Kanazawa, Susumu| Fujiwara, Toshiyoshi| |
| Abstract | Currently, chemoradiation is the most widely used nonsurgical treatment for esophageal cancer. However, some patients, particularly the very elderly or those with severe vital organ dysfunction, face difficulty with the chemotherapy component. We therefore examined the outcome of radiation therapy (RT) alone for patients with esophageal cancer at our facility. Between January 2005 and December 2014, 84 patients underwent RT at our hospital, and 78 of these patients received concomitant chemotherapy. The remaining 6 patients underwent RT alone; these patients were considered to be high-risk and to have no lymph node metastasis (stage I). Five of them received irradiation up to a curative dose: 4 showed a complete response (CR) and 1 showed a partial response (PR). Of the patients exhibiting CR, 3 are currently living recurrence-free, whereas 1 patient underwent endoscopic submucosal dissection (ESD) as salvage therapy for local recurrence, with no subsequent recurrence. High-risk stage I esophageal cancer patients can be treated radically with RT alone under certain conditions. In the future, to broaden the indications for RT monotherapy to include some degree of advanced cancers, a novel concurrent therapy should be identified. |
| Keywords | esophageal cancer radiation therapy high-risk patient |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2017-04 |
| Volume | volume71 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 127 |
| End Page | 133 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 28420894 |
| Title Alternative | Thoracoscopic esophagectomy was effective in a case of lower esophageal stenosis due to recurrence of achalasia after myotomy 40 years previously |
|---|---|
| FullText URL | 129_41.pdf |
| Author | Katsura, Yuki| Shirakawa, Yasuhiro| Tanabe, Shunsuke| Maeda, Naomi| Noma, Kazuhiro| Fujiwara, Toshiyoshi| |
| Abstract | When planning surgery for achalasia, it is important to plan for adequate myotomy and prevention of reflux. However, achalasia may recur if the procedure was inadequate or in patients with a long-term course. The present case is a 68-year-old woman who underwent myotomy of the lower esophageal sphincter 40 years ago, but recently reported difficulty in swallowing. Dilatation of the thoracic esophagus and stenosis of the abdominal esophagus were identified by examination, and the patient was diagnosed with recurrence of achalasia. After percutaneous endoscopic gastrostomy was performed to recover nutritional status, thoracoscopic esophagectomy was carried out. The patient'spost-operative course was uneventful and oral intake was enabled. At the time of writing, there has been no re-recurrence. There is no standard therapy for post-operative recurrence of achalasia. We believe that thoracoscopic esophagectomy for the recurrence of achalasia is a safe and minimally invasive alternative to conventional surgery. |
| Keywords | 食道アカラシア (achalasia) 再手術 (reoperation) 食道亜全摘 (esophagectomy) |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2017-04-03 |
| Volume | volume129 |
| Issue | issue1 |
| Start Page | 41 |
| End Page | 44 |
| ISSN | 0030-1558 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2017 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.129.41 |
| NAID | 130005632071 |
| JaLCDOI | 10.18926/AMO/53524 |
|---|---|
| FullText URL | 69_3_173.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Ohara, Toshiaki| Kashima, Hajime| Maeda, Naoaki| Tanabe, Shunsuke| Kagawa, Shunsuke| Fujiwara, Toshiyoshi| |
| Abstract | A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery. Thoracoscopic ligation of the thoracic duct has emerged as a promising and definitive treatment. The case of a 65-year-old Japanese male patient with a rare congenital right aortic arch (typeⅢB1 of Edwardʼs classification) and a severe chyle leak that occurred after a total pharyngolaryngo-esophagectomy (TPLE) is described. The chyle leak was successfully managed by thoracoscopic ligation of the thoracic duct via a left-side approach with the patient in the prone position. |
| Keywords | chyle leak thoracic duct thoracoscopy prone position |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2015-06 |
| Volume | volume69 |
| Issue | issue3 |
| Publisher | Okayama University Medical School |
| Start Page | 173 |
| End Page | 176 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2015 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 26101193 |
| Web of Science KeyUT | 000356903000006 |
| Author | Yamada, Eiji| Shirakawa, Yasuhiro| Yamatsuji, Tomoki| Sakuma, Leon| Takaoka, Munenori| Yamada, Takako| Noma, Kazuhiro| Sakurama, Kazufumi| Fujiwara, Yasuhiro| Tanabe, Shunsuke| Nagasaka, Takeshi| Fujiwara, Toshiyoshi| Naomoto, Yoshio| |
|---|---|
| Published Date | 2012-12 |
| Publication Title | Journal of Surgical Research |
| Volume | volume178 |
| Issue | issue2 |
| Content Type | Journal Article |
| JaLCDOI | 10.18926/AMO/52407 |
|---|---|
| FullText URL | 68_2_111.pdf |
| Author | Shirakawa, Yasuhiro| Noma, Kazuhiro| Maeda, Naoaki| Katsube, Ryoichi| Tanabe, Shunsuke| Ohara, Toshiaki| Sakurama, Kazufumi| Fujiwara, Toshiyoshi| |
| Abstract | Thoracoscopic esophagectomy in the prone position (TEPP) might enable solo-surgery in cases requiring resection of the esophagus and the surrounding lymph nodes due to the associated advantages of good exposure of the surgical field and ergonomic considerations for the surgeon. However, no one approach can be for all patients requiring extensive lymphadenectomy. We recently developed an assistant-based procedure to standardize exposure of the surgical field. Patients were divided into 1 of 2 groups:a pre-standardization group (n＝37) and a post-standardization group (n＝28). The thoracoscopic operative time was significantly shorter (p＝0.0037) in the post-standardization group (n＝28; 267±31min) than in the pre-standardization group (n＝37;301±53min). Further, learning curve analysis using the moving average method showed stabilization of the thoracoscopic operative time after the standardization. No significant differences were found in the number of mediastinal lymph nodes dissected or intraoperative blood loss between the 2 groups. There were also no significant differences in the complication rate. Assistant-based surgery and standardization of the procedure resulted in a well-exposed and safe surgical field. TEPP decreased the operative time, even in patients requiring extensive lymphadenectomy. |
| Keywords | thoracoscopic esophagectomy prone position standardization |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2014-04 |
| Volume | volume68 |
| Issue | issue2 |
| Publisher | Okayama University Medical School |
| Start Page | 111 |
| End Page | 117 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2014 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 24743786 |
| Web of Science KeyUT | 000334652700006 |
