Nakamura, Keiichiro - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Examining the relationship between cesarean section scar and endometrial cancer

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Author	Nakamura, Keiichiro\| Tani, Yoshinori\| Itou, Hironori\| Shimizu, Miyuki\| Dao, Thi Hai Ly\| Nakato, Hikari\| Okamoto, Kazuhiro\| Ogawa, Chikako\| Eto, Eriko\| Masuyama, Hisashi\|
Keywords	Endometrial Cancer Cesarean Section Cesarean Section Scar Interval from Delivery to Endometrial Cancer Onset Residual Myometrial Thicknes/Adjacent Myometrial Thickness Ratio
Published Date	2026
Publication Title	Journal of Gynecologic Oncology
Volume	volume37
Issue	issue5
Publisher	Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, Japan Society of Gynecologic Oncology
Start Page	e96
ISSN	2005-0380
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology
File Version	publisher
PubMed ID	41958175
DOI	10.3802/jgo.2026.37.e96
Related Url	isVersionOf https://doi.org/10.3802/jgo.2026.37.e96

A Biologically Dominant Trophoblastic Component Guiding Neoadjuvant EMA/CO in Endometrial Carcinoma: A Clinical Case Report

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Author	Shirakawa, Shinsuke\| Nagao, Shoji\| Tanaka, Yui\| Fujikawa, Atsushi\| Imatani, Ryoko\| Tanioka, Momoko\| Tani, Yoshinori\| Sugihara, Hanako\| Okamoto, Kazuhiro\| Ida, Naoyuki\| Matsuoka, Hirofumi\| Haraga, Junko\| Ogawa, Chikako\| Nakamura, Keiichiro\| Yanai, Hiroyuki\| Masuyama, Hisashi\|
Keywords	choriocarcinoma EMA/CO endometrial cancer endometrioid carcinoma
Published Date	2026-07
Publication Title	Clinical Case Reports
Volume	volume14
Issue	issue7
Publisher	Wiley
Start Page	e72982
ISSN	2050-0904
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	42396393
DOI	10.1002/ccr3.72982
Web of Science KeyUT	001809780000001
Related Url	isVersionOf https://doi.org/10.1002/ccr3.72982

Fertility-sparing surgery with neoadjuvant chemotherapy in early and locally advanced cervical cancer: A clinical protocol

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Author	Tanioka, Momoko\| Nagao, Shoji\| Ida, Naoyuki\| Tanaka, Yui\| Fujikawa, Atsushi\| Imatani, Ryoko\| Tani, Yoshinori\| Sugihara, Hanako\| Okamoto, Kazuhiro\| Matsuoka, Hirofumi\| Haraga, Junko\| Ogawa, Chikako\| Nakamura, Keiichiro\| Masuyama, Hisashi\|
Published Date	2026-01-13
Publication Title	PLOS One
Volume	volume21
Issue	issue1
Publisher	Public Library of Science (PLoS)
Start Page	e0340963
ISSN	1932-6203
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 Tanioka et al.
File Version	publisher
PubMed ID	41529018
DOI	10.1371/journal.pone.0340963
Related Url	isVersionOf https://doi.org/10.1371/journal.pone.0340963

Case Report: Multidisciplinary approach for complete resection of primary advanced low-grade serous ovarian carcinoma involving the iliac vessels and paraspinal region

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Author	Ida, Naoyuki\| Nagao, Shoji\| Fujikawa, Atsushi\| Tanaka, Yui\| Tanioka, Momoko\| Imatani, Ryoko\| Tani, Yoshinori\| Sugihara, Hanako\| Matsuoka, Hirofumi\| Okamoto, Kazuhiro\| Haraga, Junko\| Ogawa, Chikako\| Nakamura, Keiichiro\| Masuyama, Hisashi\|
Keywords	anterolateral thigh flap extra-pelvic invasion gynecologic oncology low-grade serous ovarian carcinoma multidisciplinary surgery surgical limit
Published Date	2026-02-25
Publication Title	Frontiers in Oncology
Volume	volume16
Publisher	Frontiers Media SA
Start Page	1762009
ISSN	2234-943X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 Ida, Nagao, Fujikawa, Tanaka, Tanioka, Imatani, Tani, Sugihara, Matsuoka, Okamoto, Haraga, Ogawa, Nakamura and Masuyama.
File Version	publisher
PubMed ID	41821878
DOI	10.3389/fonc.2026.1762009
Web of Science KeyUT	001710573300001
Related Url	isVersionOf https://doi.org/10.3389/fonc.2026.1762009

Evaluation of platinum-free interval and chemotherapeutic effect of subsequent platinum-containing chemotherapy in patients with recurrent ovarian cancer initially treated with bevacizumab: SGSG018/Intergroup study

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Author	Tanaka, Tamaki\| Takehara, Kazuhiro\| Usami, Tomoka\| Ishikawa, Masako\| Kondo, Eiji\| Kagabu, Masahiro\| Hirabayashi, Kei\| Matsumura, Noriomi\| Sato, Shinya\| Nishimura, Masato\| Arakawa, Atsushi\| Nakamura, Keiichiro\| Konno, Yosuke\| Fujiwara, Satoe\| Sueoka, Kotaro\| Nakamura, Hiroko\| Koh, Iemasa\| Ito, Kimihiko\| Hongo, Atsushi\|
Keywords	Ovarian cancer Bevacizumab Chemotherapy Platinum-sensitive relapse Platinum-free interval
Published Date	2025-06
Publication Title	Gynecologic Oncology Reports
Volume	volume59
Publisher	Elsevier BV
Start Page	101740
ISSN	2352-5789
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Authors.
File Version	publisher
PubMed ID	40297564
DOI	10.1016/j.gore.2025.101740
Web of Science KeyUT	001475132400001
Related Url	isVersionOf https://doi.org/10.1016/j.gore.2025.101740

Multicenter, open-label, randomized, controlled study to test the utility of electronic patient-reported outcome monitoring in patients with unresectable advanced cancers or metastatic/recurrent solid tumors

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Author	Taira, Naruto\| Kiyota, Naomi\| Kikawa, Yuichiro\| Ichihara, Eiki\| Kato, Kyoko\| Kubota, Kaoru\| Tateishi, Ryosuke\| Nakata, Akinobu\| Nakamura, Keiichiro\| Narita, Yukiya\| Hotta, Katsuyuki\| Iwata, Hiroji\| Gemma, Akihiko\| Shimozuma, Kojiro\| Muro, Kei\| Iwamoto, Tetsuya\| Takumoto, Yuki\| Shiroiwa, Takeru\| Fukuda, Takashi\| Yamaguchi, Takuhiro\| Hagiwara, Yasuhiro\| Minami, Hironobu\|
Keywords	electronic patient-reported outcomes monitoring advanced cancers systemic chemotherapy randomized controlled study quality of life overall survival
Published Date	2025-02-23
Publication Title	Japanese Journal of Clinical Oncology
Volume	volume55
Issue	issue5
Publisher	Oxford University Press (OUP)
Start Page	547
End Page	555
ISSN	1465-3621
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025.
File Version	publisher
PubMed ID	39987488
DOI	10.1093/jjco/hyaf033
Web of Science KeyUT	001431225500001
Related Url	isVersionOf https://doi.org/10.1093/jjco/hyaf033

Factors associated with period of sick leave after gynecologic cancer treatment: a prospective cohort study

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Author	Tani, Yoshinori\| Nakamura, Keiichiro\| Sugihara, Hanako\| Shirakawa, Shinsuke\| Matsuoka, Hirofumi\| Ida, Naoyuki\| Haraga, Junko\| Ogawa, Chikako\| Eto, Eriko\| Nagao, Shoji\| Masuyama, Hisashi\|
Keywords	Period of sick leave Surgery plus chemotherapy Six or more cycles of chemotherapy Gynecologic cancer survivors
Published Date	2025-11-19
Publication Title	Supportive Care in Cancer
Volume	volume33
Issue	issue12
Publisher	Springer Science and Business Media LLC
Start Page	1087
ISSN	0941-4355
NCID	AA10996793
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41258502
DOI	10.1007/s00520-025-10116-5
Web of Science KeyUT	001619218200007
Related Url	isVersionOf https://doi.org/10.1007/s00520-025-10116-5

The Concept of “Platinum Sensitivity” in Endometrial Cancer

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Author	Nagao, Shoji\| Fujikawa, Atsushi\| Imatani, Ryoko\| Tani, Yoshinori\| Matsuoka, Hirofumi\| Ida, Naoyuki\| Haraga, Junko\| Ogawa, Chikako\| Nakamura, Keiichiro\| Masuyama, Hisashi\|
Keywords	endometrial cancer platinum sensitivity platinum free interval
Published Date	2025-08-02
Publication Title	Cancers
Volume	volume17
Issue	issue15
Publisher	MDPI AG
Start Page	2557
ISSN	2072-6694
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by the authors.
File Version	publisher
PubMed ID	40805253
DOI	10.3390/cancers17152557
Web of Science KeyUT	001550660700001
Related Url	isVersionOf https://doi.org/10.3390/cancers17152557

Lymphadenectomy and chemotherapy are effective treatments for patients with 2023 international federation of gynecology and obstetrics stage IIC-high risk endometrial cancer in Japan

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Author	Tani, Yoshinori\| Nakamura, Keiichiro\| Yorimitsu, Masae\| Seki, Noriko\| Nakanishi, Mie\| Itou, Hironori\| Shimizu, Miyuki\| Yamamoto, Dan\| Takahara, Etsuko\| Masuyama, Hisashi\|
Keywords	Endometrial cancer FIGO 2023 Stage IIC high risk Lymphadenectomy Chemotherapy
Note	The version of record of this article, first published in International Journal of Clinical Oncology, is available online at Publisher’s website: http://dx.doi.org/10.1007/s10147-024-02647-4\|
Published Date	2024-11-09
Publication Title	International Journal of Clinical Oncology
Volume	volume30
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	144
End Page	156
ISSN	1341-9625
NCID	AA11086579
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	39516301
DOI	10.1007/s10147-024-02647-4
Web of Science KeyUT	001351172500001
Related Url	isVersionOf https://doi.org/10.1007/s10147-024-02647-4

ADAR1-high tumor-associated macrophages induce drug resistance and are therapeutic targets in colorectal cancer

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Author	Umeda, Hibiki\| Shigeyasu, Kunitoshi\| Takahashi, Toshiaki\| Moriwake, Kazuya\| Kondo, Yoshitaka\| Yoshida, Kazuhiro\| Takeda, Sho\| Yano, Shuya\| Matsumi, Yuki\| Kishimoto, Hiroyuki\| Fuji, Tomokazu\| Yasui, Kazuya\| Yamamoto, Hideki\| Takagi, Kosei\| Kayano, Masashi\| Michiue, Hiroyuki\| Nakamura, Keiichiro\| Mori, Yoshiko\| Teraishi, Fuminori\| Tazawa, Hiroshi\| Umeda, Yuzo\| Kagawa, Shunsuke\| Goel, Ajay\| Fujiwara, Toshiyoshi\|
Keywords	RNA-editing Macrophage Chemoresistance Biomarker Colorectal cancer
Published Date	2025-04-16
Publication Title	Molecular Cancer
Volume	volume24
Issue	issue1
Publisher	BMC
Start Page	116
ISSN	1476-4598
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025.
File Version	publisher
PubMed ID	40241135
DOI	10.1186/s12943-025-02312-y
Web of Science KeyUT	001470204500003
Related Url	isVersionOf https://doi.org/10.1186/s12943-025-02312-y

ADAR1 could be a potential diagnostic target for intrauterine infection patients

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Author	Nakamura, Keiichiro\| Shigeyasu, Kunitoshi\| Vu, Thuy Ha\| Maki, Jota\| Okamoto, Kazuhiro\| Masuyama, Hisashi\|
Keywords	ADAR1 Chorioamnionitis Funisitis Intrauterine infection Diagnostic biomarker
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-81097-4\|
Published Date	2024-11-27
Publication Title	Scientific Reports
Volume	volume14
Issue	issue1
Publisher	Nature Portfolio
Start Page	29419
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	39592688
DOI	10.1038/s41598-024-81097-4
Web of Science KeyUT	001364770700004
Related Url	isVersionOf https://doi.org/10.1038/s41598-024-81097-4

Apolipoprotein-B mRNA-editing complex 3B could be a new potential therapeutic target in endometriosis

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Author	Vu, Thuy Ha\| Nakamura, Keiichiro\| Shigeyasu, Kunitoshi\| Kashino, Chiaki\| Okamoto, Kazuhiro\| Kubo, Kotaro\| Kamada, Yasuhiko\| Masuyama, Hisashi\|
Keywords	Apolipoprotein-B mRNA-editing complex 3B Endometriosis Apoptosis Potential therapeutic target
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-76589-2\|
Published Date	2024-10-23
Publication Title	Scientific Reports
Volume	volume14
Issue	issue1
Publisher	Nature Portfolio
Start Page	24968
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	39443671
DOI	10.1038/s41598-024-76589-2
Web of Science KeyUT	001341352800136
Related Url	isVersionOf https://doi.org/10.1038/s41598-024-76589-2

Efficacy and safety of olaparib, olaparib plus bevacizumab and niraparib maintenance treatment in Japanese patients with platinum-sensitive advanced ovarian cancer

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Author	Nakamura, Keiichiro\| Matsuoka, Hirofumi\| Yorimitsu, Masae\| Ogawa, Mariko\| Kanemori, Miho\| Sueoka, Kotaro\| Kozai, Ayumi\| Nakamura, Hiroko\| Haruma, Tomoko\| Shiroyama, Yuko\| Hayata, Yuu\| Sugii, Hirokazu\| Ueda, Akiko\| Kurihara, Shuichi\| Urayama, Saiko\| Shimizu, Miyuki\| Masuyama, Hisashi\|
Keywords	olaparib olaparib plus bevacizumab niraparib renal function
Published Date	2023-09-14
Publication Title	Japanese Journal of Clinical Oncology
Volume	volume54
Issue	issue1
Publisher	Oxford University Press (OUP)
Start Page	31
End Page	37
ISSN	1465-3621
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023.
File Version	publisher
PubMed ID	37721176
DOI	10.1093/jjco/hyad125
Web of Science KeyUT	001068527100001
Related Url	isVersionOf https://doi.org/10.1093/jjco/hyad125

Not taking sick leave for gynecologic cancer treatment is negatively associated with returning to the same workplace

FullText URL	fulltext.pdf
Author	Nakamura, Keiichiro\| Matsuoka, Hirofumi\| Kubo, Kotaro\| Shirakawa, Shinsuke\| Ida, Naoyuki\| Haraga, Junko\| Ogawa, Chikako\| Okamoto, Kazuhiro\| Nagao, Shoji\| Masuyama, Hisashi\|
Keywords	returning to the same workplace gynecologic neoplasms sick leave
Published Date	2023-11-23
Publication Title	Japanese Journal of Clinical Oncology
Volume	volume54
Issue	issue3
Publisher	Oxford University Press (OUP)
Start Page	292
End Page	296
ISSN	1465-3621
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023.
File Version	publisher
PubMed ID	37995280
DOI	10.1093/jjco/hyad159
Web of Science KeyUT	001108594700001
Related Url	isVersionOf https://doi.org/10.1093/jjco/hyad159

ADAR1 has an oncogenic function and can be a prognostic factor in cervical cancer

FullText URL	fulltext.pdf
Author	Nakamura, Keiichiro\| Shigeyasu, Kunitoshi\| Okamoto, Kazuhiro\| Matsuoka, Hirofumi\| Masuyama, Hisashi\|
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-30452-y\|
Published Date	2023-03-23
Publication Title	Scientific Reports
Volume	volume13
Issue	issue1
Publisher	Nature Portfolio
Start Page	4720
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	36959226
DOI	10.1038/s41598-023-30452-y
Web of Science KeyUT	001024033600064
Related Url	isVersionOf https://doi.org/10.1038/s41598-023-30452-y

ADAR1 is a promising risk stratification biomarker of remnant liver recurrence after hepatic metastasectomy for colorectal cancer

FullText URL	fulltext.pdf
Author	Hata, Nanako\| Shigeyasu, Kunitoshi\| Umeda, Yuzo\| Yano, Shuya\| Takeda, Sho\| Yoshida, Kazuhiro\| Fuji, Tomokazu\| Yoshida, Ryuichi\| Yasui, Kazuya\| Umeda, Hibiki\| Takahashi, Toshiaki\| Kondo, Yoshitaka\| Kishimoto, Hiroyuki\| Mori, Yoshiko\| Teraishi, Fuminori\| Yamamoto, Hideki\| Michiue, Hiroyuki\| Nakamura, Keiichiro\| Tazawa, Hiroshi\| Fujiwara, Toshiyoshi\|
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-023-29397-z\|
Published Date	2023-02-06
Publication Title	Scientific Reports
Volume	volume13
Issue	issue1
Publisher	Nature Portfolio
Start Page	2078
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2023
File Version	publisher
PubMed ID	36747029
DOI	10.1038/s41598-023-29397-z
Web of Science KeyUT	000989985700018
Related Url	isVersionOf https://doi.org/10.1038/s41598-023-29397-z

Tumor size before image-guided brachytherapy is an important factor of local control after radiotherapy for cervical squamous cell carcinoma: analysis in cases using central shielding

FullText URL	fulltext.pdf
Author	Yoshio, Kotaro\| Ihara, Hiroki\| Okamoto, Kazuhiro\| Suzuki, Etsuji\| Ogata, Takeshi\| Sugiyama, Soichi\| Nakamura, Keiichiro\| Nagao, Shoji\| Masuyama, Hisashi\| Hiraki, Takao\|
Keywords	cervical cancer tumor size squamous cell carcinoma image-guided brachytherapy (IGBT) central shielding (CS)
Published Date	2022-07-05
Publication Title	Journal Of Radiation Research
Publisher	Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology
ISSN	0449-3060
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	35791439
DOI	10.1093/jrr/rrac040
Web of Science KeyUT	000820941900001
Related Url	isVersionOf https://doi.org/10.1093/jrr/rrac040

The Combination of D-dimer and Glasgow Prognostic Score Can Be Useful in Predicting VTE in Patients with Stage IIIC and IVA Ovarian Cancer

JaLCDOI	10.18926/AMO/63406
FullText URL	76_2_129.pdf
Author	Kubo, Kotaro\| Nakamura, Keiichiro\| Okamoto, Kazuhiro\| Matsuoka, Hirofumi\| Ida, Naoyuki\| Haruma, Tomoko\| Ogawa, Chikako\| Masuyama, Hisashi\|
Abstract	Cancer patients have increased risk of venous thromboembolism (VTE) that must be assessed before treatment. This study aimed to determine effective VTE biomarkers in gynecologic cancer (GC). We investigated the correlation between D-dimer levels, Khorana risk score (KRS), Glasgow prognostic score (GPS), and VTE in 1499 GC patients (583 cervical cancer (CC), 621 endometrial cancer (EC), and 295 ovarian cancer (OC) patients) treated at our institution between January 2008 and December 2019. χ2 and Mann–Whitney U-tests were used to determine statistical significance. We used receiver operating characteristic-curve analysis to evaluate the discriminatory ability of each parameter. D-dimer levels were significantly correlated with KRS and GPS in patients with GC. VTE was diagnosed in 11 CC (1.9%), 27 EC (4.3%), and 39 OC patients (13.2%). Optimal D-dimer cut-off values for VTE were 3.1, 3.2, and 3.9 μg/ml in CC, EC and OC patients, respectively. D-dimer could significantly predict VTE in all GC patients. Furthermore, D-dimer combined with GPS was more accurate in predicting VTE than other VTE biomarkers in stage IIIC and IVA OC (AUC: 0.846; p<0.001). This study demonstrates that combined D-dimer and GPS are useful in predicting VTE in patients with OC.
Keywords	D-dimer gynecologic cancer venous thromboembolism
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2022-04
Volume	volume76
Issue	issue2
Publisher	Okayama University Medical School
Start Page	129
End Page	135
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2022 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	35503440
Web of Science KeyUT	000792374900004

EG-VEGF Induces Invasion of a Human Trophoblast Cell Line via PROKR2

JaLCDOI	10.18926/AMO/62806
FullText URL	75_6_677.pdf
Author	Tani Kazumasa\| Mitsui, Takashi\| Mishima, Sakurako\| Ohira, Akiko\| Maki, Jota\| Eto, Eriko\| Hayata, Kei\| Nakamura, Keiichiro\| Masuyama, Hisashi\|
Abstract	Extravillous trophoblast (EVT) invasion is important for embryo implantation, placental development, and successful remodeling of the uterine spiral artery. Endocrine gland derived-vascular endothelial growth factor (EG-VEGF) and matrix metalloproteinases (MMPs) are implicated in EVT invasion; however, the high con-centrations found in pregnancy pathologies have not been investigated in non-tumor trophoblasts. The roles of EG-VEGF, prokineticin receptors (PROKR1/2), MMP-2, and MMP-9 in EVT invasion during spiral artery remodeling were evaluated using human EVT from HTR-8/SVneo cell lines. The expression of MMP-2, MMP-9, and mitogen-activated protein kinase (MAPK), and Akt pathways in HTR-8/SVneo cells treated with recom-binant EG-VEGF alongside anti-PROKR1 and/or anti-PROKR2 antibodies was evaluated using quantitative reverse transcription-PCR and western blotting. Wound-healing and cell invasion assays were performed to assess the migration and invasion of these treated cells. Interestingly, 20 nM EG-VEGF activated ERK1/2 sig-naling and upregulated MMP-2 and MMP-9. This effect was suppressed by anti-PROKR2 antibody via ERK1/2 downregulation. Anti-PROKR2 antibody inhibited the migration and invasion of EG-VEGF-stimulated HTR-8/SVneo cells. Elevated concentrations of EG-VEGF enhance EVT invasion in a human trophoblast cell line by upregulating MMP-2 and MMP-9 via PROKR2. These new insights into the regulation of epithelial cell invasion may help in developing therapeutic interventions for placental-related diseases during pregnancy.
Keywords	endocrine gland-derived vascular endothelial growth factor prokineticin extravillous trophoblast matrix metalloproteinase obstetric diseases
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2021-12
Volume	volume75
Issue	issue6
Publisher	Okayama University Medical School
Start Page	677
End Page	684
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	34955534
Web of Science KeyUT	000735297900002
NAID	120007180286

Successful Treatment of Acute Promyelocytic Leukemia Complicated with Endometrial Cancer by Arsenic Trioxide

JaLCDOI	10.18926/AMO/61904
FullText URL	75_2_219.pdf
Author	Sugiura, Hiroyuki\| Nishimori, Hisakazu\| Matsuoka, Hirofumi\| Nakamura, Keiichiro\| Fujii, Keiko\| Fujii, Nobuharu \| Matsuoka, Ken-ichi \| Maeda, Yoshinobu\|
Abstract	Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumor’s treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer.
Keywords	acute promyelocytic leukemia endometrial cancer arsenic trioxide synchronous multiple primary malignant tumor chemotherapy
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2021-04
Volume	volume75
Issue	issue2
Publisher	Okayama University Medical School
Start Page	219
End Page	224
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	33953429
NAID	120007029883