Togashi, Yosuke - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Molecular characteristics and clinical outcomes of ERBB2-activating mutation-positive non-small cell lung cancer: A Japanese nationwide real-world cohort

FullText URL	fulltext.pdf
Author	Yamashita, Masahiro\| Ninomiya, Kiichiro\| Tomida, Shuta\| Nakata, Eiji\| Morita, Ayako\| Hara, Naofumi\| Takada, Kenji\| Makimoto, Go\| Kubo, Toshio\| Ichihara, Eiki\| Ohashi, Kadoaki\| Hotta, Katsuyuki\| Togashi, Yosuke\| Maeda, Yoshinobu\| Ennishi, Daisuke\|
Keywords	ERBB2 mutation Variant subtype Comprehensive genomic profiling Trastuzumab-deruxtecan Non-small cell lung cancer
Published Date	2026-11
Publication Title	European Journal of Cancer
Volume	volume248
Publisher	Elsevier BV
Start Page	117443
ISSN	0959-8049
NCID	AA1075407X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	42826440
DOI	10.1016/j.ejca.2026.117443
Related Url	isVersionOf https://doi.org/10.1016/j.ejca.2026.117443

ULK1, a novel therapeutic target to delay drug tolerance to EGFR–TKIs in an EGFR-mutant non-small cell lung cancer model

FullText URL	fulltext.pdf
Author	Morita, Ayako\| Rai, Kammei\| Kuribayashi, Tadahiro\| Tomida, Shuta\| Nishi, Tatsuya\| Hara, Naofumi\| Makimoto, Go\| Ninomiya, Kiichiro\| Kubo, Toshio\| Ohashi, Kadoaki\| Hotta, Katsuyuki\| Ochi, Nobuaki\| Togashi, Yosuke\| Maeda, Yoshinobu\| Ichihara, Eiki\|
Keywords	ULK1 Autophagy EGFR TKI Osimertinib Non-small cell lung cancer
Published Date	2026-08
Publication Title	Lung Cancer
Volume	volume218
Publisher	Elsevier BV
Start Page	109516
ISSN	0169-5002
NCID	AA10785743
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	42407241
DOI	10.1016/j.lungcan.2026.109516
Web of Science KeyUT	001820763100001
Related Url	isVersionOf https://doi.org/10.1016/j.lungcan.2026.109516

Limited Immune-Mediated Efficacy of Anti-PD-L1/VEGF in EGFR-TKI-Naïve Egfr-Mutant Lung Cancer with Non-Inflamed Tumor Microenvironment

FullText URL	fulltext.pdf
Author	Hirabae, Atsuko\| Kuribayashi, Tadahiro\| Tomida, Shuta\| Okawa, Sachi\| Nakasuka, Takamasa\| Nishii, Kazuya\| Nishimura, Jun\| Makimoto, Go\| Ninomiya, Kiichiro\| Higo, Hisao\| Rai, Kammei\| Ichihara, Eiki\| Hotta, Katsuyuki\| Sugimoto, Masamichi\| Togashi, Yosuke\| Maeda, Yoshinobu\| Kiura, Katsuyuki\| Ohashi, Kadoaki\|
Keywords	EGFR mutation non-small cell lung cancer syngeneic mouse model antitumor immunity non-inflamed tumor VEGF PD-L1
Published Date	2026-05-27
Publication Title	Current Oncology
Volume	volume33
Issue	issue6
Publisher	MDPI AG
Start Page	315
ISSN	1718-7729
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 by the authors.
File Version	publisher
PubMed ID	42346215
DOI	10.3390/curroncol33060315
Web of Science KeyUT	001801988600001
Related Url	isVersionOf https://doi.org/10.3390/curroncol33060315

Endotracheal and Endobronchial Metastases in Epidermal Growth Factor Receptor Exon 19 Deletion Lung Adenocarcinoma: A Case Successfully Managed with Bronchoscopic Therapy and Sequential Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

FullText URL	fulltext.pdf
Author	Fujiwara, Miho\| Baba, Takahiro\| Yamada, Kotaro\| Nakamura, Eri\| Takeguchi, Tetsuya\| Takigawa, Yuki\| Morita, Ayako\| Hara, Naofumi\| Watanabe, Hiromi\| Ninomiya, Kiichiro\| Rai, Kammei\| Ichihara, Eiki\| Ohashi, Kadoaki\| Hotta, Katsuyuki\| Sato, Ken\| Maeda, Yoshinobu\| Togashi, Yosuke\| Makimoto, Go\|
Keywords	EGFR C797S EGFR exon 19 deletion endotracheal metastasis lung adenocarcinoma TBLC
Published Date	2026-06-01
Publication Title	Internal Medicine
Volume	volume65
Issue	issue11
Publisher	Japanese Society of Internal Medicine
Start Page	1520
End Page	1523
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 by The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	41125377
DOI	10.2169/internalmedicine.6220-25
CRID	1390308444986903040
Web of Science KeyUT	001600551000001
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.6220-25

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in <i>Egfr</i> ‐mutated lung cancer

FullText URL	fulltext.pdf
Author	Nishimura, Jun\| Kuribayashi, Tadahiro\| Brägelmann, Johannes\| Okawa, Sachi\| Taoka, Masataka\| Mori, Shunta\| Nishimura, Tomoka\| Tanaka, Takaaki\| Makimoto, Go\| Ninomiya, Kiichiro\| Rai, Kammei\| Ichihara, Eiki\| Katayama, Ryohei\| Hotta, Katsuyuki\| Tabata, Masahiro\| Togashi, Yosuke\| Maeda, Yoshinobu\| Sos, Martin L.\| Kiura, Katsuyuki\| Ohashi, Kadoaki\|
Keywords	abscopal effect CD8+ T cells EGFR mutation EGFR tyrosine kinase inhibitor NK cells stimulator of interferon genes
Published Date	2026-05-21
Publication Title	Molecular Oncology
Publisher	Wiley
ISSN	1574-7891
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	42169500
DOI	10.1002/1878-0261.70264
Web of Science KeyUT	001771369500001
Related Url	isVersionOf https://doi.org/10.1002/1878-0261.70264

Afatinib Overcomes Osimertinib Resistance via Egfr V804F Mutation in a Syngeneic Egfr-Mutant Lung Cancer Mouse Model

FullText URL	fulltext.pdf
Author	Tanaka, Takaaki\| Fujitani, Masato\| Taoka, Masataka\| Shimomura, Iwao\| Okawa, Sachi\| Mori, Shunta\| Kuribayashi, Tadahiro\| Nishimura, Jun\| Nishimura, Tomoka\| Morita, Ayako\| Hara, Naofumi\| Ninomiya, Kiichiro\| Makimoto, Go\| Higo, Hisao\| Rai, Kammei\| Ichihara, Eiki\| Tomida, Shuta\| Hotta, Katsuyuki\| Togashi, Yosuke\| Maeda, Yoshinobu\| Kiura, Katsuyuki\| Katayama, Ryohei\| Ohashi, Kadoaki\|
Keywords	afatinib EGFR-mutant NSCLC exon 19 deletion osimertinib resistance V802F (human EGFR)/V804F (murine Egfr)
Published Date	2026-06-01
Publication Title	Cancer Science
Publisher	Wiley
Start Page	1
End Page	17
ISSN	1347-9032
NCID	AA11808050
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	42226508
DOI	10.1111/cas.70431
Web of Science KeyUT	001781129700001
Related Url	isVersionOf https://doi.org/10.1111/cas.70431

Immunological effects of amivantamab in EGFR or MET-expressing non-small cell lung cancer

FullText URL	fulltext.pdf
Author	Yoshichika, Ryo\| Mukohara, Fumiaki\| Yamada, Kotaro\| Nagasaki, Joji\| Watanabe, Hiroko\| Ueda, Youki\| Suzawa, Ken\| Shien, Kazuhiko\| Toyooka, Shinichi\| Ishino, Takamasa\| Togashi, Yosuke\|
Keywords	Non-small cell lung cancer Amivantamab Antitumor immunity EGFR MET
Published Date	2026-03-24
Publication Title	Cancer Immunology, Immunotherapy
Volume	volume75
Issue	issue4
Publisher	Springer Science and Business Media LLC
Start Page	121
ISSN	1432-0851
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2026
File Version	publisher
PubMed ID	41874698
DOI	10.1007/s00262-026-04369-0
Web of Science KeyUT	001722743200001
Related Url	isVersionOf https://doi.org/10.1007/s00262-026-04369-0

TGF-β Inhibitor Potentiates Osimertinib-Induced Anti-Tumor Immunity in Egfr-Mutant Lung Cancer

FullText URL	fulltext.pdf
Author	Kuribayashi, Tadahiro\| Nishimura, Jun\| Okawa, Sachi\| Taoka, Masataka\| Mori, Shunta\| Tanaka, Takaaki\| Nishimura, Tomoka\| Morita, Ayako\| Hara, Naofumi\| Ninomiya, Kiichiro\| Makimoto, Go\| Rai, Kammei\| Ichihara, Eiki\| Hotta, Katsuyuki\| Togashi, Yosuke\| Maeda, Yoshinobu\| Kiura, Katsuyuki\| Ohashi, Kadoaki\|
Keywords	EGFR lung cancer nintedanib osimertinib TGF-β
Published Date	2026-02-27
Publication Title	Cancer Science
Volume	volume117
Issue	issue5
Publisher	Wiley
Start Page	1260
End Page	1272
ISSN	1347-9032
NCID	AA11808050
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Author(s).
File Version	publisher
PubMed ID	41757675
DOI	10.1111/cas.70352
Web of Science KeyUT	001702773200001
Related Url	isVersionOf https://doi.org/10.1111/cas.70352

Risk Factors for Waiting List Mortality in Lung Transplant Candidates With Post‐Hematopoietic Stem Cell Transplantation Non‐Infectious Pulmonary Complications

FullText URL	fulltext.pdf
Author	Higo, Hisao\| Senoo, Satoru\| Makimoto, Satoko\| Nagano, Tomohiro\| Kondo, Takumi\| Yamamoto, Haruchika\| Tanaka, Shin\| Miyoshi, Kentaroh\| Sugimoto, Seiichiro\| Toyooka, Shinichi\| Maeda, Yoshinobu\| Togashi, Yosuke\| Miyahara, Nobuaki\|
Keywords	hematopoietic stem cell transplantation late-onset non-infectious pulmonary complications lung transplantation pneumothorax
Published Date	2026-05-28
Publication Title	Clinical Transplantation
Volume	volume40
Issue	issue6
Publisher	Wiley
Start Page	e70582
ISSN	0902-0063
NCID	AA10694240
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	©2026 The Author(s).
File Version	publisher
PubMed ID	42206540
DOI	10.1111/ctr.70582
Related Url	isVersionOf https://doi.org/10.1111/ctr.70582

Incidence of B-cell Malignancies in Patients with Lung Cancer Receiving PD-1 Blockade Therapy

FullText URL	fulltext.pdf
Author	Ninomiya, Toshifumi\| Fang, Caiyang\| Hamano, Hirofumi\| Morinaga, Teruya\| Zhou, Wenhao\| Koyama, Toshihiro\| Miki, Sakura\| Zhu, Li\| Naoi, Yusuke\| Ennishi, Daisuke\| Katsuta, Tomoya\| Ohashi, Kadoaki\| Morizane, Shin\| Ohki-Ikeda, Tomoka\| Nishi, Tatsuya\| Ueda, Youki\| Ishino, Takamasa\| Maeda, Yoshinobu\| Okamoto, Isamu\| Zamami, Yoshito\| Nagasaki, Joji\| Togashi, Yosuke\|
Published Date	2026-05-19
Publication Title	Clinical Cancer Research
Publisher	American Association for Cancer Research (AACR)
ISSN	1078-0432
NCID	AA11029881
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	©2026 The Authors
File Version	publisher
PubMed ID	42148884
DOI	10.1158/1078-0432.ccr-25-3406
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Clinical Characteristics and Spatial Transcriptome Analysis of Non–Small Cell Lung Cancers Exhibiting Early Alectinib Resistance: A Retrospective OLCSG Study

FullText URL	fulltext.pdf
Author	Kuribayashi, Tadahiro\| Makimoto, Go\| Ohashi, Kadoaki\| Tomida, Shuta\| Inoue, Hirofumi\| Yokoyama, Toshihide\| Kuyama, Shoichi\| Kato, Yuka\| Kudo, Kenichiro\| Horita, Naokatsu\| Kayatani, Hiroe\| Inoue, Masaaki\| Sugimoto, Keisuke\| Ninomiya, Kiichiro\| Maeda, Yoshinobu\| Togashi, Yosuke\| Hotta, Katsuyuki\|
Published Date	2026-02-01
Publication Title	Cancer Research Communications
Volume	volume6
Issue	issue2
Publisher	American Association for Cancer Research (AACR)
Start Page	284
End Page	293
ISSN	2767-9764
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2026 The Authors
File Version	publisher
PubMed ID	41529251
DOI	10.1158/2767-9764.crc-25-0545
Web of Science KeyUT	001693865300001
Related Url	isVersionOf https://doi.org/10.1158/2767-9764.crc-25-0545

Immunopeptidomics combined with full-length transcriptomics uncovers diverse neoantigens

FullText URL	fulltext.pdf
Author	Ishino, Takamasa\| Watanabe, Tomofumi\| Tokita, Serina\| Ueda, Youki\| Kawase, Katsushige\| Takano, Yuka\| Thu, Yin Min\| Suzuki, Yuta\| Owa, Chie\| Inozume, Takashi\| Zhou, Wenhao\| Nagasaki, Joji\| Kochin, Vitaly\| Ueno, Toshihide\| Kojima, Shinya\| Honobe-Tabuchi, Akiko\| Kawamura, Tatsuyoshi\| Ohnuma, Takehiro\| Matsuzawa, Takamitsu\| Kawahara, Yu\| Yamashita, Kazuo\| Lin, Jason\| Koseki, Jun\| Nishikawa, Hiroyoshi\| Araki, Motoo\| Kato, Naoya\| Shimamura, Teppei\| Morishita, Shinichi\| Suzuki, Yutaka\| Mano, Hiroyuki\| Torigoe, Toshihiko\| Kanaseki, Takayuki\| Kawazu, Masahito\| Togashi, Yosuke\|
Keywords	cancer immunology neoantigen long-read RNA sequencing HLA ligandome single-cell RNA sequencing single-cell TCR sequencing exhausted T cell
Published Date	2026-01
Publication Title	Cell Reports
Volume	volume45
Issue	issue1
Publisher	Elsevier BV
Start Page	116781
ISSN	2211-1247
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	41447530
DOI	10.1016/j.celrep.2025.116781
Web of Science KeyUT	001654870700001
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Single-cell and spatial transcriptomic characterization of pulmonary pleomorphic carcinoma

FullText URL	fulltext.pdf
Author	Matsuoka, Atsushi\| Shien, Kazuhiko\| Tomida, Shuta\| Ohki, Masayoshi\| Hisamatsu, Kazuya\| Fujiwara, Ryota\| Ishimura, Kosei\| Fujii, Ryunosuke\| Higashihara, Tomoaki\| Hayashi, Naohiro\| Okada, Kazuhiro\| Yoshichika, Ryo\| Mukohara, Fumiaki\| Yoshikawa, Mao\| Fukumoto, Yuma\| Suzawa, Ken\| Tomioka, Yasuaki\| Tanaka, Shin\| Miyoshi, Kentaroh\| Okazaki, Mikio\| Sugimoto, Seiichiro\| Otani, Yusuke\| Tanaka, Atsushi\| Inoue, Hirofumi\| Togashi, Yosuke\| Yamamoto, Hidetaka\| Ennishi, Daisuke\| Toyooka, Shinichi\|
Published Date	2025-12-16
Publication Title	Communications Biology
Volume	volume8
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	1773
ISSN	2399-3642
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41402584
DOI	10.1038/s42003-025-09162-w
Related Url	isVersionOf https://doi.org/10.1038/s42003-025-09162-w

A Prompt Diagnosis of Ascites and Dramatic Effect of Alectinib for Advanced Lung Adenocarcinoma Harboring EML4-ALK Fusion

FullText URL	fulltext.pdf
Author	Baba, Takahiro\| Inoue, Hirofumi\| Matsuoka, Hiromi\| Kyakuno, Mio\| Yoshinaga, Yusuke\| Takeguchi, Tetsuya\| Fujiwara, Miho\| Yamada, Kotaro\| Nakamura, Eri\| Morita, Ayako\| Hara, Naofumi\| Ninomiya, Kiichiro\| Higo, Hisao\| Fujii, Masanori\| Ichihara, Eiki\| Rai, Kammei\| Ohashi, Kadoaki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Togashi, Yosuke\| Makimoto, Go\|
Keywords	lung adenocarcinoma EML4-ALK AmoyDxⓇ Pan Lung Cancer PCR Panel alectinib
Published Date	2025-12-01
Publication Title	Internal Medicine
Volume	volume64
Issue	issue23
Publisher	Japanese Society of Internal Medicine
Start Page	3413
End Page	3418
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 by The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	40399085
DOI	10.2169/internalmedicine.5397-25
Web of Science KeyUT	001494126400001
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.5397-25

Optogenetic Cancer Therapy Using the Light-Driven Outward Proton Pump Rhodopsin Archaerhodopsin-3 (AR3)

Author	Nakao, Shin\| Kojima, Keiichi\| Sato, Keita\| Kemmotsu, Naoya\| Ohuchi, Hideyo\| Togashi, Yosuke\| Sudo, Yuki\|
Note	This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the American Chemical Society, copyright © 2025 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/jacs.5c13053.\| This fulltext file will be available in Nov. 2026.\|
Published Date	2025-11-04
Publication Title	Journal of the American Chemical Society
Publisher	American Chemical Society (ACS)
ISSN	0002-7863
NCID	AA00692602
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 American Chemical Society
File Version	author
PubMed ID	41186408
DOI	10.1021/jacs.5c13053
Web of Science KeyUT	001607655700001
Related Url	isVersionOf https://doi.org/10.1021/jacs.5c13053

Immune evasion through mitochondrial transfer in the tumour microenvironment

FullText URL	fulltext.pdf 41586_2024_8439_MOESM1_ESM.pdf Supplementary Tables-legends.docx 2022-12-20357D-Supplementary Table 1.xlsx 2022-12-20357D-Supplementary Table 2.xlsx 2022-12-20357D-Supplementary Table 3.pdf 2022-12-20357D-Supplementary Table 4.xlsx 2022-12-20357D-Supplementary Table 5.pdf 2022-12-20357D-Supplementary Table 6.pdf
Author	Ikeda, Hideki\| Kawase, Katsushige\| Nishi, Tatsuya\| Watanabe, Tomofumi\| Takenaga, Keizo\| Inozume, Takashi\| Ishino, Takamasa\| Aki, Sho\| Lin, Jason\| Kawashima, Shusuke\| Nagasaki, Joji\| Ueda, Youki\| Suzuki, Shinichiro\| Makinoshima, Hideki\| Itami, Makiko\| Nakamura, Yuki\| Tatsumi, Yasutoshi\| Suenaga, Yusuke\| Morinaga, Takao\| Honobe-Tabuchi, Akiko\| Ohnuma, Takehiro\| Kawamura, Tatsuyoshi\| Umeda, Yoshiyasu\| Nakamura, Yasuhiro\| Kiniwa, Yukiko\| Ichihara, Eiki\| Hayashi, Hidetoshi\| Ikeda, Jun-ichiro\| Hanazawa, Toyoyuki\| Toyooka, Shinichi\| Mano, Hiroyuki\| Suzuki, Takuji\| Osawa, Tsuyoshi\| Kawazu, Masahito\| Togashi, Yosuke\|
Published Date	2025-01-22
Publication Title	Nature
Volume	volume638
Issue	issue8049
Publisher	Springer Science and Business Media LLC
Start Page	225
End Page	236
ISSN	0028-0836
NCID	AA00752384
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025, corrected publication 2025
File Version	publisher
PubMed ID	39843734
DOI	10.1038/s41586-024-08439-0
Web of Science KeyUT	001401954800001
Related Url	isVersionOf https://doi.org/10.1038/s41586-024-08439-0

High Antigenicity for Treg Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in Treg Cells

FullText URL	fulltext.pdf
Author	Matsuura, Hiroaki\| Ishino, Takamasa\| Ninomiya, Toshifumi\| Ninomiya, Kiichiro\| Tachibana, Kota\| Honobe-Tabuchi, Akiko\| Muto, Yoshinori\| Inozume, Takashi\| Ueda, Youki\| Ohashi, Kadoaki\| Maeda, Yoshinobu\| Nagasaki, Joji\| Togashi, Yosuke\|
Keywords	antigenicity cancer immunotherapy CTLA-4 PD-1 regulatory T cell
Published Date	2025-02-27
Publication Title	Cancer Science
Volume	volume116
Issue	issue5
Publisher	Wiley
Start Page	1214
End Page	1226
ISSN	1347-9032
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Author(s).
File Version	publisher
PubMed ID	40017103
DOI	10.1111/cas.70029
Web of Science KeyUT	001479679200005
Related Url	isVersionOf https://doi.org/10.1111/cas.70029

Somatic mutations in tumor-infiltrating lymphocytes impact on antitumor immunity

FullText URL	fulltext20250213-02.pdf suppl20250213-02.pdf
Author	Mukohara, Fumiaki\| Iwata, Kazuma\| Ishino, Takamasa\| Inozume, Takashi\| Nagasaki, Joji\| Ueda, Youki\| Suzawa, Ken\| Ueno, Toshihide\| Ikeda, Hideki\| Kawase, Katsushige\| Saeki, Yuka\| Kawashima, Shusuke\| Yamashita, Kazuo\| Kawahara, Yu\| Nakamura, Yasuhiro\| Honobe-Tabuchi, Akiko\| Watanabe, Hiroko\| Dansako, Hiromichi\| Kawamura, Tatsuyoshi\| Suzuki, Yutaka\| Honda, Hiroaki\| Mano, Hiroyuki\| Toyooka, Shinichi\| Kawazu, Masahito\| Togashi, Yosuke\|
Keywords	cancer immunology somatic mutation T cell tumor-infiltrating lymphocytes
Note	This is an Accepted Manuscript of an article published by Proceedings of the National Academy of Sciences.\| This fulltext file will be available in Feb. 2025.\|
Published Date	2024-08-21
Publication Title	Proceedings of the National Academy of Sciences
Volume	volume121
Issue	issue35
Publisher	Proceedings of the National Academy of Sciences
Start Page	e2320189121
ISSN	0027-8424
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 the Author(s).
File Version	author
PubMed ID	39167601
DOI	10.1073/pnas.2320189121
Web of Science KeyUT	001408603100001
Related Url	isVersionOf https://doi.org/10.1073/pnas.2320189121

Overcoming immunotherapy resistance and inducing abscopal effects with boron neutron immunotherapy (B-NIT)

FullText URL	fulltext.pdf
Author	Fujimoto, Takuya\| Yamasaki, Osamu\| Kanehira, Noriyuki\| Matsushita, Hirokazu\| Sakurai, Yoshinori\| Kenmotsu, Naoya\| Mizuta, Ryo\| Kondo, Natsuko\| Takata, Takushi\| Kitamatsu, Mizuki\| Igawa, Kazuyo\| Fujimura, Atsushi\| Otani, Yoshihiro\| Shirakawa, Makoto\| Shigeyasu, Kunitoshi\| Teraishi, Fuminori\| Togashi, Yosuke\| Suzuki, Minoru\| Fujiwara, Toshiyoshi\| Michiue, Hiroyuki\|
Keywords	abscopal effect advanced melanoma boron neutron capture therapy boron-neutron immunotherapy immune combination therapy
Published Date	2024-08-09
Publication Title	Cancer Science
Volume	volume115
Issue	issue10
Publisher	Wiley
Start Page	3231
End Page	3247
ISSN	1347-9032
NCID	AA11808050
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Author(s).
File Version	publisher
PubMed ID	39119813
DOI	10.1111/cas.16298
Web of Science KeyUT	001287521700001
Related Url	isVersionOf https://doi.org/10.1111/cas.16298

Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment

FullText URL	fulltext20240226-03.pdf
Author	Zhou, Wenhao\| Kawashima, Shusuke\| Ishino, Takamasa\| Kawase, Katsushige\| Ueda, Youki\| Yamashita, Kazuo\| Watanabe, Tomofumi\| Kawazu, Masahito\| Dansako, Hiromichi\| Suzuki, Yutaka\| Nishikawa, Hiroyoshi\| Inozume, Takashi\| Nagasaki, Joji\| Togashi, Yosuke\|
Keywords	cancer immunology follicular helper T cell cytotoxic CD4+ T cell CXCL13 T cell exhaustion stem-like progenitor exhaustion terminally differentiated exhaustion PD-1 LAG-3 TCF1
Note	Immune checkpoint inhibitors exert clinical efficacy against various types of cancer through reinvigoration of exhausted CD8+ T cells that attack cancer cells directly in the tumor microenvironment (TME). Using single-cell sequencing and mouse models, we show that CXCL13, highly expressed in tumor-infiltrating exhausted CD8+ T cells, induces CD4+ follicular helper T (TFH) cell infiltration, contributing to anti-tumor immunity. Furthermore, a part of the TFH cells in the TME exhibits cytotoxicity and directly attacks major histocompatibility complex-II-expressing tumors. TFH-like cytotoxic CD4+ T cells have high LAG-3/BLIMP1 and low TCF1 expression without self-renewal ability, whereas non-cytotoxic TFH cells express low LAG-3/BLIMP1 and high TCF1 with self-renewal ability, closely resembling the relationship between terminally differentiated and stem-like progenitor exhaustion in CD8+ T cells, respectively. Our findings provide deep insights into TFH-like CD4+ T cell exhaustion with helper progenitor and cytotoxic differentiated functions, mediating anti-tumor immunity orchestrally with CD8+ T cells.\|
Published Date	2024-02-27
Publication Title	Cell Reports
Volume	volume43
Issue	issue2
Publisher	Elsevier BV
Start Page	113797
ISSN	2211-1247
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2024 The Author(s).
File Version	publisher
PubMed ID	38363680
DOI	10.1016/j.celrep.2024.113797
Web of Science KeyUT	001185865700001
Related Url	isVersionOf https://doi.org/10.1016/j.celrep.2024.113797