start-ver=1.4
cd-journal=joma
no-vol=66
cd-vols=
no-issue=3
article-no=
start-page=183
end-page=190
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=201206
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Dynamin 2 in Charcot-Marie-Tooth Disease
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Charcot-Marie-Tooth disease (CMT) is an inherited neuronal disorder, and is induced by mutations of various genes associated with intracellular membrane traffic and cytoskeleton. A large GTPase, dynamin, which is known as a fission protein for endocytic vesicles, was identified as a gene responsible
for dominant-intermediate CMT type 2B (DI-CMT2B). Of these mutants, the PH domain, which is required for interaction with phosphoinositides, was mutated in several families. Interestingly, the expression of a deletion mutant, 551Δ3, did not impair endocytosis, but induced abnormal accumulation
of microtubules. Recent evidence has shown that dynamin 2 regulates the dynamic instability of microtubules, and 551Δ3 lacks this function. We propose a model for the regulation of the dynamic instability of microtubules by dynamin 2 and discuss the relationship between dynamin 2 and CMT.
en-copyright=
kn-copyright=

en-aut-name=TanabeKenji
en-aut-sei=Tanabe
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakeiKohji
en-aut-sei=Takei
en-aut-mei=Kohji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Neuroscience, Okayama University Graduate School of Medicine

affil-num=2
en-affil=
kn-affil=Department of Neuroscience, Okayama University Graduate School of Medicine
en-keyword=neuropathy
kn-keyword=neuropathy
en-keyword=Charcot-Marie-Tooth disease
kn-keyword=Charcot-Marie-Tooth disease
en-keyword=membrane traffic
kn-keyword=membrane traffic
en-keyword=dynamin
kn-keyword=dynamin
en-keyword=microtubules
kn-keyword=microtubules
END

start-ver=1.4
cd-journal=joma
no-vol=122
cd-vols=
no-issue=2
article-no=
start-page=113
end-page=117
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2010
dt-pub=20100802
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Dynamic instability of microtubules regulated by Dynamin2 and Charcot-Marie-Tooth disease
kn-title=ダイナミン2による微小管の動態制御とCharcot-Marie-Tooth病
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=TanabeKenji
en-aut-sei=Tanabe
en-aut-mei=Kenji
kn-aut-name=田邊賢司
kn-aut-sei=田邊
kn-aut-mei=賢司
aut-affil-num=1
ORCID=

en-aut-name=TakeiKohji
en-aut-sei=Takei
en-aut-mei=Kohji
kn-aut-name=竹居孝二
kn-aut-sei=竹居
kn-aut-mei=孝二
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　生化学

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　生化学
en-keyword=神経疾患
kn-keyword=神経疾患
en-keyword=Charcot-Marie-Tooth病
kn-keyword=Charcot-Marie-Tooth病
en-keyword=細胞内輸送
kn-keyword=細胞内輸送
en-keyword=微小管
kn-keyword=微小管
en-keyword=ダイナミン
kn-keyword=ダイナミン
END