岡山実験動物研究会Acta Medica Okayama332017カフェインによるアレルギー性鼻炎の抑制効果1821ENMadokaTsujimotoGraduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University AkikoSaikiGraduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin UniversityManamiSuzukiGraduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin UniversityToshiyukiShiragaGraduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin UniversityYukioSugimotoOkayama University Graduate School of Medicine, Dentistry and Pharmaceutical SciencesYasushiHayashiGraduate School of Human Life Sciences, Department of Foods and Human Nutrition, Notre Dame Seishin University We examined the effects of caffeine treatment on ovalbumin- and histamine-induced rhinitis mouse models and on corticosterone and catecholamine levels in mouse plasma. Treatment with caffeine decreased sneezing and nasal rubbing in both models, but direct nasal administration had no effect. Plasma levels of corticosterone and catecholamine, which have known anti-allergy effects, were increased by caffeine treatment. The increases in corticosterone and catecholamine may be associated with the suppression of rhinitis symptoms.No potential conflict of interest relevant to this article was reported.Pergamon-Elsevier Science Ltd.Acta Medica Okayama0960-894X21192011In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A59015904ENHidekazuIshimotoMariShibataYukiMyojinHideyukiItoYukioSugimotoAkihiroTaiTsutomuHatanoUrolithin A is a major metabolite produced by rats and humans after consumption of pomegranate juice or pure ellagitannin geraniin. In this study, we investigated the anti-inflammatory effect of urolithin A on carrageenan-induced paw edema in mice. The volume of paw edema was reduced at 1 h after oral administration of urolithin A. In addition, plasma in treated mice exhibited significant oxygen radical antioxidant capacity (ORAC) scores with high plasma levels of the unconjugated form at 1 h after oral administration of urolithin A. These results indicate strong associations among plasma urolithin A levels, the plasma ORAC scores, and anti-inflammatory effects and may help explain a mechanism by which ellagitannins confer protection against inflammatory diseases.No potential conflict of interest relevant to this article was reported.Okayama University Medical SchoolActa Medica Okayama0386-300X5361999Effects of levocabastine on lipid mediator release from guinea pig lung fragments.271274ENYukioSugimotoYoshionoriIbaKeisukeIshizawaGenzoSuzukiChiakiKameiBrief Note10.18926/AMO/31623<p><p>The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10(-4) M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.</p></p>No potential conflict of interest relevant to this article was reported.岡山実験動物研究会Acta Medica Okayama202003アレルギー性疾患の動物モデル4547ENYukioSugimotoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama1998新規アレルギー性疾患モデルの作製とその応用ENNo potential conflict of interest relevant to this article was reported.