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ID 61201
Author
Yamamoto, Haruchika Department of Thoracic Surgery, Okayama University Hospital
Yamamoto, Hiromasa Department of Thoracic Surgery, Okayama University Hospital ORCID Kaken ID publons researchmap
Soh, Junichi Department of Thoracic Surgery, Okayama University Hospital
Suzuki, Etsuji Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons researchmap
Namba, Kei Department of Thoracic Surgery, Okayama University Hospital
Suzawa, Ken Department of Thoracic Surgery, Okayama University Hospital ORCID Kaken ID researchmap
Miyoshi, Kentaroh Department of Thoracic Surgery, Okayama University Hospital Kaken ID
Otani, Shinji Department of Thoracic Surgery, Okayama University Hospital
Okazaki, Mikio Department of Thoracic Surgery, Okayama University Hospital
Sugimoto, Seiichiro Department of Thoracic Surgery, Okayama University Hospital ORCID Kaken ID publons researchmap
Yamane, Masaomi Department of Thoracic Surgery, Okayama University Hospital Kaken ID researchmap
Yorifuji, Takashi Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Takahashi, Katsuhito Center for Multidisciplinary Treatment of Sarcoma, Department of Sarcoma Medicine, Kameda Medical Center
Toyooka, Shinichi Department of Thoracic Surgery, Okayama University Hospital ORCID Kaken ID publons researchmap
Abstract
Background
Pulmonary metastasectomy could be considered one of the treatment options for disease control in sarcoma patients with pulmonary metastases; however, there is little consensus regarding the suitable criteria for predicting the likely outcomes in these patients. The aim of this study was to establish a prognostic benefit scoring system based on preoperatively examined prognostic factors for sarcoma patients with pulmonary metastases.
Methods
This was a single-center, retrospective cohort study conducted in a cohort of 135 sarcoma patients who underwent a first pulmonary metastasectomy at Okayama University Hospital between January 2006 and December 2015. Based on the results of a multivariable logistic regression analysis performed to determine the factors influencing 3-year mortality, a Sarcoma Lung Metastasis Score was created and its correlation with 3-year survival was analyzed.
Results
The results of the multivariate analysis revealed significant differences in the disease-free interval (< 2 years vs. ≥ 2 years; odds ratio (OR) 4.22, 95% confidence interval (CI) 1.67–10.70), maximum tumor diameter (≥ 15 mm vs. < 15 mm; OR 3.86, 95% CI 1.75–8.52), and number of pulmonary metastases (≥ 6 vs. < 6; OR 2.65, 95% CI 1.06–6.620). The Sarcoma Lung Metastasis Score, which was defined as the total score of these three factors, reliably predicted 3-year survival (score: 0, 89.5%; 1, 63.2%; 2, 39.0%; 3, 10.5%).
Conclusions
Our newly proposed simple Sarcoma Lung Metastasis Score appears to be a useful prognostic predictor for sarcoma patients with pulmonary metastases, in that it could be helpful for the selection of appropriate treatments for these patients.
Note
This is a post-peer-review, pre-copyedit version of an article published in Annals of Surgical Oncology. The final authenticated version is available online at: http://dx.doi.org/10.1245/s10434-020-09272-1.
This fulltext is available in November, 2021.
Published Date
2020-11-24
Publication Title
Annals of Surgical Oncology
Publisher
Springer
ISSN
1068-9265
NCID
AA11016573
Content Type
Journal Article
language
英語
File Version
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PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1245/s10434-020-09272-1