岡山医学会 Acta Medica Okayama 0030-1558 126 1 2014 PET/CT SUVmaxは子宮体癌の予後不良因子になりうる 11 15 EN Keiichiro Nakamura Ikuo Joja Chikako Fukushima Tomoko Haruma Chiaki Hayashi Tomoyuki Kusumoto Noriko Seki Atsushi Hongo Yuji Hiramatsu No potential conflict of interest relevant to this article was reported.

Okayama University Medical School Acta Medica Okayama 0386-300X 66 6 2012 Endometrial Polyps:MR Imaging Features 475 485 EN Soichiro Hase Akihito Mitsumori Ryota Inai Mitsuhiro Takemoto Shinichiro Matsubara Nobuo Akamatsu Masayoshi Fujisawa Ikuo Joja Shuhei Sato Susumu Kanazawa Original Article 10.18926/AMO/49044 The purpose of this study is to evaluate the diagnostic usefulness of magnetic resonance imaging (MRI) characteristics of endometrial polyps in order to differentiate them from other endometrial lesions. MRI was retrospectively reviewed in 40 patients with pathologically proven endometrial polyps. Special attention was paid to the sizes, shapes, margins, internal structures, signal intensities, and post-contrast enhancement patterns. A central fibrous core, intratumoral cysts, and hemorrhage were seen in 30 (75%), 22 (55%), and 14 (35%) patients, respectively. The predominant signal intensity of the lesions showed iso-to slightly low signal intensity relative to the endometrium on T2-weighted images in 36 (90%), low signal intensity on diffusion-weighted images in 32 (80%), and strong or moderate enhancement on enhanced T1-weighted images in 28 patients (70%), respectively. In 32 (80%) patients, the endometrial polyps showed global or partial early enhancement. On dynamic study, rapid enhancement with a persistent strong enhancement pattern was seen in 17 (42.5%) and a gradually increasing enhancement pattern was seen in 17 patients (42.5%). These MRI features can be helpful to distinguish the endometrial polyps from various other endometrial lesions. No potential conflict of interest relevant to this article was reported.

Okayama University Medical School Acta Medica Okayama 0386-300X 53 2 1999 The Results of Radiotherapy for T1 Glottic Cancers: Influence of Radiation Beam Energy 91 94 EN Michinori Yamamoto Ikuo Joja Mitsuhiro Takemoto Masahiro Kuroda Yoshio Hiraki Article 10.18926/AMO/31630 We analyzed the influence of various parameters on the results of radiotherapy for T1 glottic cancer by assessing the outcomes of 60 patients with this cancer who received definitive radiotherapy between 1985 and 1994. Seven patients were treated with a cobalt-60 unit, and the other 53 with a linear accelerator (26 patients at 3-MV, 10 at 6-MV, and 17 at 10-MV). Of the 17 patients treated at 10-MV, 4 also received part of their treatment with a cobalt-60 unit. The total radiation dose ranged from 56 Gy to 70 Gy (mean, 61 Gy). The total radiation dose of 51 patients (85%) was 60 Gy. The factors found to influence local control were the strength of the radiation beam energy and whether or not there was gross tumor invasion of the anterior commissure. The local control rate was 71% in the patients treated with a 10-MV linear accelerator, 56% in those treated with a 6-MV linear accelerator and, 97% in those treated with a cobalt-60 unit or a 3-MV linear accelerator (P = 0.0173). The local control rate was 43% in the patients with gross anterior commissure invasion and 88% in those without (P = 0.0075). We conclude that low energy photon beams are more suitable for the treatment of early glottic cancers, especially if the lesion grossly invades the anterior commissure. No potential conflict of interest relevant to this article was reported.

Okayama University Medical School Acta Medica Okayama 0386-300X 47 3 1993 Hyperthermotherapy added to the multidisciplinary therapy for penile cancer. 169 174 EN Masahiro Kuroda Tomoyasu Tsushima Yasutomo Nasu Junichi Asaumi Koji Nishikawa Xian Shu Gao Ikuo Joja Yoshihiro Takeda Izumi Togami Eiichi Makihata Shoji Kawasaki Hiroyuki Ohmori Yoshio Hiraki Article 10.18926/AMO/31599 <p>We performed a long-term follow-up of 4 patients with penile cancer who underwent hyperthermotherapy from August 1985 until August 1992. Hyperthermia was applied using a frequency of 350 MHz with a waveguide applicator twice a week for 60 min each for an average of 9.5 times (varying from 6 to 13 times). The total heating time that the temperature of urethra could be kept above 42 degrees C, was 166 min on the average (ranging from 0 to 463 min). Two patients classified as stage I according to the Jackson classification and 1 patient classified as stage IV underwent combined radiotherapy and received an average radiation dose of 53 Gy (range, 40-70 Gy). Among these patients 2 underwent combined chemotherapy with bleomycin or peplomycin. Malignant cells disappeared posttherapeutically and in August 1992, after an average of 5 years and 9 months (varying from 4 years 6 months to 6 years 10 months), the patients were free of recurrences. The one patient on stage IV had extensive invasion of the abdominal wall, but still recovered completely. One patient on stage III underwent combined chemotherapy and hyperthermotherapy, but heating had obviously been insufficient. There was a residue of malignant cells after the treatment and we performed a penectomy. Regarding functional preservation of the penis a multidisciplinary therapy incorporating hyperthermotherapy can be expected to increase the curativity. This indicates that it could induce in an advanced case, where an operation would be difficult, complete remission.</p> No potential conflict of interest relevant to this article was reported.

Okayama University Medical School Acta Medica Okayama 0386-300X 47 4 1993 Hyperthermotherapy for postoperative local recurrences of rectal cancer. 249 254 EN Masahiro Kuroda Akio Hizuta Hiromi Iwagaki Eiichi Makihata Junichi Asaumi Koji Nishikawa Xian Shu Gao Tomio Nakagawa Izumi Togami Yoshihiro Takeda Ikuo Joja Shoji Kawasaki Kunzo Orita Yoshio Hiraki Article 10.18926/AMO/31557 <p>Between November 1984 and August 1992 we used hyperthermotherapy in six cases of local recurrence of rectal cancer. Hyperthermotherapy was performed on the average 8.7 times (range: 3-18) for each patient for 60 min each. All patients underwent combined radiotherapy and received a mean radiation dose of 42.5 Gy (range: 9-60 Gy). Five patients underwent heating within 1 h after irradiation and one patient simultaneously with the irradiation. Four patients underwent combined chemotherapy and two patients immunotherapy. Before the treatment all patients had painful lesions, but pain decreased posttherapeutically in five patients. Performance status improved in two patients. High carcinoembryonic antigen levels prior to the therapy in four patients decreased in all cases after treatment. Posttherapeutical computed tomograms revealed only minor response or no changes. After the treatment, four patients died of exacerbations of recurrent tumors and one patient of distant metastases. The patient who underwent simultaneous radiohyperthermotherapy is presently alive, in August 1992, 38 months after initiation of the treatment. The 50% survival time after initiation of the treatment was 25 months (range: 10-38 months). Hyperthermotherapy combined with radiotherapy, chemotherapy and/or immunotherapy was useful for the alleviation of pain in patients who developed local recurrence after surgery, and improved survival after recurrences can be expected.</p> No potential conflict of interest relevant to this article was reported.

Okayama University Medical School Acta Medica Okayama 0386-300X 62 3 2008 Basic Study of Susceptibility-Weighted Imaging at 1.5T 159 168 EN Toshi Matsushita Daigo Anami Tadashi Arioka Seiji Inoue Yusuke Kariya Masako Fujimoto Kentaro Ida Nobuya Sasai Mitsumasa Kaji Susumu Kanazawa Ikuo Joja Original Article 10.18926/AMO/30978 <p>With the aim of sequence optimization in susceptibility-weighted imaging (SWI), 2 image acquisition parameters (slice thickness and matrix size) and 2 image processing conditions (number of slices per minimum intensity projection (MIP) and Sliding Window) were investigated using a 1.5-T magnetic resonance imaging (MRI) system. The subjects were 12 healthy volunteers and the target region for scanning was the whole brain. Informed consent was obtained from all subjects. First, susceptibility-weighted images were acquired with various slice thicknesses from 1mm to 5mm and various matrix sizes from 256x256 to 512x512, and the images were assessed in terms of the contrast-to-noise ratio (CNR) and were also visually evaluated by three radiologists. Then, the number of slices per MIP and the usefulness of the Sliding Window were investigated. In the study of the optimal slice thickness and matrix size, the results of visual evaluation suggested that a slice thickness of 3mm and a matrix size of 448x448 are optimal, while the results of evaluation based on CNR were not significant. As regards the image processing conditions, the results suggested that the number of slices per MIP should be set to a minimum value of 2 and that the use of Sliding Window is effective. The present study provides useful reference data for optimizing SWI sequences.</p> No potential conflict of interest relevant to this article was reported.

Okayama University Medical School Acta Medica Okayama 0386-300X 51 2 1997 Preoperative multidisciplinary treatment with hyperthermia for soft tissue sarcoma 93 99 EN Eiichi Makihata Masahiro Kuroda Akira Kawai Toshifumi Ozaki Shinsuke Sugihara Hajime Inoue Ikuo Joja Junichi Asaumi Shoji Kawasaki Yoshio Hiraki Article 10.18926/AMO/30776 <p>We report the results of phase I/II studies of preoperative multidisciplinary treatment of 14 patients with soft tissue sarcoma using hyperthermia from November 1990 to April 1995. The preoperative treatment was conducted with thermo-radio-chemotherapy in 11 cases of stage III, and with thermo-radiotherapy as well as thermo-chemotherapy in three cases of stages I and II. Hyperthermia was carried out twice a week with totals ranging from 4 to 14 times (average: 8.4 times); each session lasted 60min. Radiotherapy was administered four or five times per week, and the dose was 1.8 2Gy/fraction, with a total of 30-40Gy in a four week period. Chemotherapy was mainly in the form of MAID regimen (2-mercaptoethanesulphonic acid (mesna), adriamycin, ifosfamide and dacarbazine). The tumors were surgically resected in all patients after completing the preoperative treatment. The efficacy rate, as expressed by the percentage of either tumors in which reduction rate was 50% or more, or tumors for which post-treatment contrast enhanced CT image revealed low density volumes occupying 50% or more of the total mass, was 71 % (ten of the 14 tumors). The mean tumor necrosis rate in the resected specimens was 78%. The tumor necrosis rate was significantly high (P &#60; 0.05) in patients whose Time &#8805; 42°C was of long duration. Postoperative complications were observed in six patients; among these, two patients developed wound infection that required surgical treatment as a complication of surgery performed in the early stage following the preoperative treatment. After a mean postoperative follow-up of 27 months, distant metastasis occurred in four patients resulting in three fatalities. The three-year cumulative survival rate was 64.3%. No local recurrence was observed in any patient during the follow-up, thus confirming our hypothesis that preoperative multidisciplinary treatment has an excellent local efficacy. We think that it would be valuable to conduct, at many facilities, phase III studies on the treatment of soft tissue sarcoma by a combination of surgery and preoperative multidisciplinary treatment using hyperthermia, paying close attention to the interval between these two modalities.</p> No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 92 9-10 1980 脂質過酸化反応によるミトコンドリァ機能の変化とビスコクラウリン型アルカロイドによる阻害作用 1015 1024 EN Kaname Aono Setsuo Morimoto Keiji Hashimoto Katashi Sato Ikuo Joja Shin Kimoto Hiroshi Ezoe Yoshihiro Takeda Masayoshi Miyake Hidehiro Hayashi Hisao Wakabayashi Toyosato Tamai Yasuo Morino Noriyuki Shiraishi During investigation of the changes in mitochondrial function accompanying lipid peroxidation, it was found that a biscoclaurine alkaroid protected their functional changes. The results obtained were as follows: 1) Fe(2+) induces lipid peroxidation of isolated mitochondria, resulting in deterioration of oxidative phosphorylation. 2) This deterioration relates to alteration in ion compartmentation of the mitochondrial membrane and an increase in latent ATPase activity. 3) This deterioration by Fe(2+) in ion compartmentation of mitochondrial membrane is strongly protected by a biscoclaurine alkaloid, cepharanthine. 4) Cepharanthine also inhibits the mitochondrial. lipid peroxidation induced by Fe(2+). 5) The protective effect of cepharanthine against deterioration in mitochondrial functions caused by Fe(2+) depends on its inhibitive action on lipid peroxidation as well as on its membrane stabilizing action. 6) Cepharanthine inhibits the lipid peroxidation of soybean lecithine liposomes by (60)Co-irradiation. 7) The action of cepharanthine described above is common to head to head type of biscoclaurin alkaloids which have diether bonds. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 91 11-12 1979 小児潰瘍性大腸炎の1例 1499 1505 EN Kazuhiko Ehara Ikuo Joja Katashi Sato Keiji Hashimoto Setsuo Morimoto Toyosato Tamai Yasuo Morino Katsuhiko Sugita Yoshio Hiraki Kaname Aono Masatada Tanabe Michio Yamamoto Ulcerative colitis in childhood is a rare disease in Japan. A 10-year-old male child was admitted to Okayama University Hospital with a chief complaint of mucous and bloody diarrhea. He had been treated conservatively in another hospital, but the symptoms had not improved. Barium enema examination revealed, from the sigmoid to the transverse colon, abnormal barium coating, numerous small niches, disappearance of the network pattern, and faint spiculations along the margins. Endoscopy demonstrated slight edema, hyperemia, easy bleeding and some purulent secretion. Biopsy specimens showed infiltration of lymphocytes, plasma cells and eosinophilic leucocytes in the mucosa. We made a diagnosis of ulcerative colitis. The patient responded poorly to Salazopyrin and Penicillin, but improved considerably with corticosteroids. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 94 11-12 1982 食道癌の放射線治療成績 1037 1044 EN Toyosato Tamai Masatada Tanabe Kaname Aono Kiichiro Mizukawa Hisao Wakabayashi Katashi Satoh Setsuo Morimoto Motoomi Ohkawa Ikuo Johja Kanji Kojima Shin Kimoto During the 6 years from 1969 to 1974, 31 patients with esophageal cancer were treated by radiotherapy with focal doses above 4,000 rad (40Gy). Cobalt 60 gamma rays were employed for the irradiation with parallel-opposing portals. Survival rates for these patients were 45.1% for 1 year, 12.9% for 2 years, 9.7% for 3 and 4 years, and 6.5% for 5 years; they mean survival time was 16.2 months. The results were tabulated according to the tumor types, lengths and sites and according to doses. Two of the 3 cases who survived more than 4 years were irradiated with 10,000 rad (100Gy) and more focal doses including reirradiation of local recurrences. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 91 5-6 1979 肋骨軟骨肉腫の1例 555 560 EN Yasuo Morino Setsuo Morimoto Katashi Sato Keiji Hashimoto Ikuo Joja Toyosato Tamai Kaname Aono Masatada Tanabe Hatsuzo Uchida Nobuyoshi Shimizu A 64 year old male was admitted to the Okayama University Medical School Hospital in June 1976. Although the patient had no subjective symptoms, the chest X-ray film revealed a tumor shadow in the left upper lung field. The tumor shadow was 8×9 cm, well demarcated, and homogenous. In 1969, at the time of an episode of pneumonia, the tumor shadow was 3×3 cm. At operation, the tumor was a chondrosarcoma of rib origin. The chest roentgenograms are described in this report. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 93 7-8 1981 十二指腸球部多発陰影欠損について 701 708 EN Yasuo Morino Yoshihiro Takeda Setsuo Morimoto Masayoshi Miyake Hidehiro Hayashi Hiroshi Ezoe Shin Kimoto Ikuo Joja Keiji Hashimoto Kaname Aono Kyoichi Hayashi Kazuko Takaoka Yukiko Oshima Multiple polypoid filling defects of the duodenal bulb are infrequently encountered. Two cases of multiple filling defects of the duodenal bulb are reported in this paper. Case 1. A 42 year old female complained of abdominal fullness and epigastralgia. On examination, generalized peripheral lymphadenopathy and marked hepatosplenomegaly were noted. Cervical lymphnode biopsy revealed a diffuse, poorly-differanciated lymphocytic lymphoma. X-ray examination of the gastrointestinal tract showed multiple filling defects localized at the duodenal bulb. Endoscopy disclosed multiple well-defined protrusions with small mucosal ulceration over the the whole circumference of the duodenal wall. Case 2. A 36 year old female had no subjective symptoms. At gastric mass screening, numerous polypoid elevations of the duodenal bulb were pointed out. Detailed gastrointestinal x-ray examination showed numerous, tiny, round polypoid nodules localized at the duodenal bulb. These nodules were 2-3mm in size with no mucosal ulceration. The endoscopic biopsy specimen revealed lymphoid hyperplasia of the duodenal bulb. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 93 1-2 1981 膵疾患におけるCT診断 63 78 EN Kaname Aono Yasuo Morino Toyosato Tamai Hisao Wakabayashi Setsuo Morimoto Keiji Hashimoto Katashi Sato Ikuo Joja Shin Kimoto Hiroshi Ezoe Yoshihiro Takeda Masayoshi Miyake Hidehiro Hayashi The diagnosis of pancreatic diseases is difficult and examination techniques such as hypo tonic duodenography, ERSP, and PTC have been used to facilitate this. Computerized tomography (CT) has recently been introduced for the diagnosis of abdominal organs, and grea hopes were held for its application in pancreatic disease. However, according to reports bases on numerous clinical experiments, it is concluded that its value is not so high as expected Therefore, under present conditions, we are obliged to depend on other diagnostic technique which require great skill and cause pain to patients. This report deals with investigation o the image in cases we have experienced. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 98 7-8 1986 血管芽細胞腫(中川)の放射線治療 687 695 EN Yoshio Hiraki Setsuo Morimoto Nobuo Satoh Yoshio Yamamoto Toshiaki Shirakami Ikuo Joja Shin Kimoto Keiji Hashimoto Kaname Aono Yoshitada Nakagiri Kenzo Arakawa Percent depth dose curves of Lineac electron beam and Dermopan soft X-ray, which are used for radiation therapy of surface tumors, were studied in 2 patients with angioblastoma (Nakagawa) who had been followed up for a long time after radiation therapy. The results are discussed with a review of the literature. Lineac electron beam therapy at low doses that do not cause remote complications appeared to be useful in the treatment of surface tumors selected after careful consideration of the indications. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 97 9-10 1985 放射線治療を施行した原発性肺癌患者における血清フェリチン値の臨床的評価 ―血清CEA値と比較して― 823 831 EN Izumi Togami Yoshio Hiraki Shin Kimoto Toshiaki Shirakami Hiroyuki Ueda Nobuo Satoh Tetsuya Nakamura Hiromichi Yamamoto Ikuo Joja Keiji Hashimoto Setsuo Morimoto Kaname Aono Yoshihiro Takeda Serum ferritin and serum carcinogenic embryonic antigen (CEA) levels in 153 patients (male: 112, female: 41) with primary lung cancer were simultaneously measured and compared with the histological type, clinical stage and clinical course. No correlation between serum ferritin and CEA levels was found. A higher percentage of positive test results for both serum ferritin and CEA was associated with advanced stages and metastasis in other organs. From the point of view of histological classification, high ferritin levels were mainly found in the patients with small-cell types of cancer. In contrast, high CEA levels were found in patients with adenocarcinoma. Therefore, the measurement of serum ferritin was not efficient as a screening test for lung cancer. Serum ferritin levels were, however, correlated with the efficacy of therapy and the clinical course. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 97 9-10 1985 磁気共鳴画像による悪性リンパ腫の診断 805 814 EN Ikuo Joja Yoshio Hiraki Hiroyuki Ueda Tetsuya Nakamura Yoshio Yamamoto Mitumasa Kaji Izumi Togami Harutaka Niiya Toshiaki Shirakami Hidehiro Hayashi Shin Kimoto Kaname Aono Katsuhiko Sugita Hiroshi Ueoka Taisuke Ohnoshi Ikuro Kimura Magnetic resonance imaging (MRI) of pathological lymphnodes was reviewed in 12 patients with malignant lymphoma. We examined the characteristics of the images and T(1) values of lesions. Short SE was the most appropriate pulse sequence to delineate the lesions. It was intermediate in signal intensity between that of skeletal muscle and that of fat tissue. On IR image, the signal intensity of skeletal muscle or lung tissue was similar to that of lymphnodes, and on long SE image, that of fat tissue was similar to that of lymphnodes. It was difficult to differentiate Hodgkin's disease (HD) from non Hodgkin's lymphoma (NHL) using only T(1) values. The long SE signal intensity of the latter was higher than that of the former. The distribution of NHL was wider than that of HD. Though MRI has various problems such as long scan time and respiratory motion artifacts, it has various merits which other methods do hot have. We consider MRI to have an important role in the diagnosis and follow up of patients with malignant lymphoma. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 98 3-4 1986 椎骨動脈の石灰化 CT像と臨床症状との対比 323 330 EN Keiji Hashimoto Shin Kimoto Toshiaki Shirakami Ikuo Joja Hidehiro Hayashi Yoshihiro Takeda Izumi Togami Harutaka Niiya Hiroyuki Ueda Mitsuharu Shimizu Katsuhiko Sugita Yoshio Hiraki Kaname Aono Mitsumasa Kaji We analyzed calcifications in 557 computed tomography films of the head. Adnormal findings of calcification of vertebral arteroes were obrained in 36 of the 577 cases. In the 36 cases, vertigo was observed in 24 cases (66.7%), and brain atrophy in 10 cases (27.2%). The calcification of vertebral arteries (arteriosclerosis) correlated significantly with vertigo. Patients with vertigo should be examined by computed tomography for calcification of vertebral arteries at the level of the foramen magnum. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 97 5-6 1985 左側下大静脈の一例 475 480 EN Keiji Hashimoto Shin Kimoto Ikuo Jouja Yoshio Yamamoto Hiroyuki Ueda Mitsumasa Kaji Toshiaki Shirakami Yoshio Hiraki Kaname Aono Katsuhiko Sugita We found a case of left-sided inferior vena cava(ivc) by chance upon upper abdominal CT examination. Left-sided ivc rarely presents clinical symptoms, but it is necessary to distinguish ivc from abnormal masses such as retroperitoneal tumors or lymphnodal swelling. We discussed left-sided ivc and the literature about it. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 97 3-4 1985 脂質過酸化反応に対するセファランチンの影響について 235 248 EN Ikuo Joja The effect of cepharanthine on radiation- and Fe(2+)-induced lipid peroxidation was examined. Cepharanthine and α-tocopherol inhibited radiation-induced lipid peroxidation of liposomes and Fe(2+)-induced lipid peroxidation of mitochondria. Cepharanthine reduced the velocity of Fe(2+)oxidation in the presence of mitochondria but not in the absence. α-Tocopherol strongly inhibited radiation-induced peroxidation of lipid dissolved in MeOH/CHCl(3)/H(2)O (v/v, 2/1/0.8) and Fe(2+)-induced peroxidation of lipid dissolved in MeOH. Cepharanthine, on the other hand, only weakly inhibited lipid peroxidation in the MeOH/CHCl(3)/H(2)O system, and did not inhibit peroxidation in the MeOH system. The change in the absorption stectrum of α-tocopherol and cepharanthine by free radicals (X irradiation) was measured. The reagents were dissolved in 95% EtOH acidified with 20mM HCl and MeOH/CHCl(3)/H(2)O (v/v, 2/1/0.8). α-Tocopherol exhibited a change in its absorption spectrum in both systems and seemed to be oxidized at a higher rate by radicals. However, cepharanthine did not exhibit a change in its absorption spectrum in acidified 95% EtOH exposed to X irradiation, and slightly exhibited a chang in its absorption spectrum in MeOH/CHCl(3)/H(2)O exposed to X irradiation. From these observations, cepharanthine seemed not to exhibit a radical-trapping ability. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 98 1-2 1986 大動脈瘤のMRI 41 48 EN Mitumasa Kaji Ikuo Joja Mituharu Shimizu Tetsuya Nakamura Hiroyuki Ueda Yoshio Yamamoto Toshiaki Shirakami Shin Komoto Keiji Hashimoto Setsuo Morimoto Katsuhiko Sugita Yoshio Hiraki Kaname Aono Hatsuzou Utida Shigeru Teramoto At Okayama University Medical School, the clinical application of magnetic resonance imaging (MRI) started in August 1984, and 16 patients with aortic aneurysm have been imaged by short spin echo (TR400msec, TE40msec) with a Toshiba MRT-15A (resistive type of magnet with a strength of 0.15T).MRI demonstrated the intimal flap and enabled the differentiatian between true and false lumens from the signal intensity. Thrombi were shown with high intensity and were differentiated from fast blood flow, but in some cases clots could not be distinguished from slow flow.MRI in which multiple planes are imaged directly without contrast medium, is a very useful imaging modality for the evaluation of aortic aneurysm. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 97 1-2 1985 NMR-CTの初期臨床経験 101 112 EN Ikuo Joja Nobuo Sato Mamoru Fujishima Mitsumasa Kaji Izumi Togami Harutaka Niiya Toshiaki Shirakami Hiromichi Yamamoto Yoshihiro Takeda Shin Kimoto Keiji Hashimoto Setsuo Morimoto Katsuhiko Sugita Yoshio Hiraki Kaname Aono We have used an NMR-CT scanner clinically since August 1 1984. We report herein the operating pulse sepuences, and present 5 cases of 226 cases that we have examined. From our clinical experience during the past four months, we describe the advantages and disadvantages of NMR-CT. The advantages are that: 1) it is possible to recognize blood vessels without contrast materials and to evaluate the blood flow 2) there are neither bone nor air artifacts, and 3) it is possible to get the tomogram in any direction. The disadvantages are that: 1) the examination time is very long, 2) there are artifacts from ferromagnetic substances placed in the body, 3) when palse sequence is changed, images are different from each other, and 4) because of respiratory motion artifacts, the images of the chest and abdomen are inferior to those of other parts of the body. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 97 1-2 1985 骨転移放射線治療において骨シンチグラムで病巣範囲決定に問題があった2症例の検討 91 99 EN Hiroyuki Ueda Keiji Hashimoto Ikuo Jyoja Shin Kimoto Yoshihiro Takeda Mitsumasa Kaji Nobuo Sato Tetsuya Nakamura Hiroyuki Hino Naoki Koyama Yoshio Hiraki Kaname Aono Radiation therapy for bone metastasis of malignant tumors is useful for reducing pain and is often used. Bone scintigraphy is useful for the early detection of bone metastasis and for staging, and is important in making plans for the irradiation of metastatic bone lesions. However, the images of metastatic bone lesions vary, so the irradiation field must be decided by comparison with plain films, computed tomography, and so on. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 97 1-2 1985 各種疾患における血清フェリチン値の臨床的評価 55 63 EN Yoshihiro Takeda Yoshio Hiraki Setsuo Morimoto Izumi Togami Toshiaki Shirakami Noriyuki Shiraishi Shin Kimoto Ikuo Joja Keiji Hashimoto Kaname Aono Serum ferritin levels were determined in 75 hematologic, 1205 malignant, and 538 benign diseases. In hematologic diseases the serum ferritin level was generally low in iron deficiency anemia, but high in hemochromatosis, aplastic anemia, and leukemia. In malignant diseases the serum ferritin concentration was increased remarkably in lung, liver, biliary, and urogential diseases and in malignant lymphoma. Among benign diseases hepatitis cases showed a tendency for high serum ferritin levels. Serum ferritin levels are influenced by various factors, and their careful evaluation may be essential for understanding of the underlining disease process. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 99 7-8 1987 転移性骨腫瘍の臨床症状 1013 1016 EN Nobuo Satoh Hiroyuki Ueda Tetsuya Nakamura Masahiro Kuroda Noriko Kanzaki Akihumi Mizuta Kiminori Murakami Ikuo Joja Keiji Hashimoto Yoshio Hiraki Kaname Aono The study included 40 cases of bone metastasis experienced from January 1982 to August 1986 at the Department of Radiology, Okayama University Hospital. The rate of pain Remission was 89.6% in 29 patients given radiotherapy. Increases in serum ALP and LDH were found in a few patients and a quarter of these patients improved after radiotherapy. Serum Ca increased in 5 patients with multiple bone metastases. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 100 7-8 1988 髄膜腫のMRI 743 751 EN Yoshio Yamamoto Yoshio Hiraki Mitumasa Kaji Hidehiro Hayashi Toshiaki Noriyasu Nobuhiro Inoue Masahiro Mitani Mamoru Fujishima Ikuo Joja Keiji Hashimmoto Shin Kimoto Kaname Aono MRI has gained a prominent position in the diagnosis of brain tumors. We examined 30 cases of meningiomas and distinguished their subtype according to the criteria of Rubinic histology. We discussed the MRI findings and compared then with X-CT findings so to their intensity, delination of tumors, whether accompanied by peripheral edema, and T(1) values. MRI delinated the tumors as well as CE-CT. No remarkable difference was found between the subtypes. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 99 1-2 1987 肺癌脳転移の放射線治療 15 23 EN Hidehiro Hayashi Yoshio Hiraki Ikuo Joja Naoko Kashitani Masayoshi Miyake Yoshio Yamamoto Noriko Kanzaki Nobuhiro Inoue Toshiaki Noriyasu Keiji Hashimoto Yoshihiro Takeda Akihumi Mizuta Katsuhiko Sugita Kaname Aono We studied the results of radiotherapy in 65 patients with brain metastases of lung cancer. In the 34 patients whose treatment consisted of radiotherapy alone, the median survival time was 164 days and the mean survival time was 210 days. Remission was achieved in 29 (85%) of these patients, indicating that radiotherapy was effective. A minimum radiation dose of 30 Gy was necessary to decrease neurological symptoms, and 40 Gy or more was considered to be desirable. Survival after radiotherapy appeared to be dependent largely on factors other than brain metastases such as the effectiveness of management of the primary lesion, the presence or the extent of metastases to other organs, and the patient's general condition. Our study suggests that greater efforts must be made for early detection and early treatment to achieve prolongation of as well as qualitative improvements in the survival time. No potential conflict of interest relevant to this article was reported.

岡山大学医療技術短期大学部 Acta Medica Okayama 0917-4494 7 2 1997 混合粒子型硫酸バリウム｢バリトゲンHD｣の評価 105 112 EN Eitarou Nobuhara Yoshihiro Takeda Kohichi Shibuya Nobuhiro Oguri Tadashi Arioka Sachiko Goto Yasuki Morioka Harutaka Niiya Yoshitada Nakagiri Ikuo Joja Katsuhiko Sugita Yoshio Hiraki 10.18926/15290 混合粒子型硫酸バリウムバリトゲンHD200w/v%懸濁液について,バリトゲン160w/v%懸濁液と比較検討を行った｡懸濁液安定性は両者共良かった｡臨床評価においては,付着性,胃小区描出能は同程度であり,辺縁の描出能は良かったが凝集･ムラ付き,気泡は多くみられ懸濁液濃度について検討を加える必要があると考える｡飲み易さは,バリトゲンHD200w/v%懸濁液のほうが濃度が高いのにもかかわらず飲み易く好評であった｡ No potential conflict of interest relevant to this article was reported.

岡山大学医療技術短期大学部 Acta Medica Okayama 0917-4494 8 1 1997 側頭葉てんかんの海馬萎縮と臨床像の検討 ―MRIを用いた海馬萎縮の簡易評価― 31 35 EN Keiko Sato Motoi Okamoto Ikuo Joja Takeshi Nakatsu Kiyoshi Morimoto Toshiyuki Hayabara Shigetoshi Kuroda 10.18926/15281 側頭葉てんかん患者39例の海馬萎縮をMRIを用いて評価し,臨床像との関連を検討した｡MRIの冠状断short SE像で海馬の幅を計測し,萎縮側海馬の村側海馬に対する比(a)を求め,海馬萎縮(+)群;a<0.8,11例,境界群;0.8≦a<0.9,13例,海馬萎縮(-)群;a≧0.9,15例の3群に分けた｡海馬萎縮(+)群で罹病期間が長い傾向があった｡また,発作間歇期脳波の焦点側は海馬委縮(+)群の11例中9例で萎縮側と一致した。しかし,発病年齢,MRI撮影時年齢,発作頻度,全般化発作の有無,抗てんかん薬総服用量,知能障害,精神症状,生下時仮死の有無については3群間で差が認められなかった｡この結果から,側頭葉てんかんにおける海馬萎縮は,生下時や全身けいれん発作時の低酸素状態によるものではなく,脳局所の反復するてんかん性発射と関連する可能性が示唆され,海馬萎縮の機序を考えるうえで興味深く思われた。 No potential conflict of interest relevant to this article was reported.

岡山大学医療技術短期大学部 Acta Medica Okayama 0917-4494 9 1 1998 混合粒子型硫酸バリウム｢バリトゲンHD｣の評価 ―第二報― 41 48 EN Eitarou Nobuhara Yoshihiro Takeda Harutaka Niiya Koichi Shibuya Yasuki Morioka Yoshitada Nakagiri Ikuo Joja Katsuhiko Sugita Yoshio Hiraki 10.18926/15274 混合粒子型硫酸バリウム｢バリトゲンHD｣の懸濁液最適濃度について,検討を行った｡懸濁液安定性は,200w/v%と190w/v%は良好であったが,180w/v%は不良で臨床使用には不向きであると思われた｡臨床的評価において200w/v%と190w/v%は付着性,辺縁の描出能,胃小区描出能においては同程度であった｡200w/v%に多く見られた凝集･ムラ付き,気泡は,190w/v%では少なくなった｡飲み易さは,200w/v%,190w/v%とも飲み易いと評価されたが,190w/v%でより飲み易い傾向にあった｡バリトゲンHDの最適懸濁液濃度は,190w/v%であると思われる｡ No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 108 3-6 1996 マウス口腔粘膜および頭部皮膚に対する血管収縮剤エピネフリンの放射線防護効果の検討 139 144 EN Xianshu Gao Tomio Nakagawa Michinori Yamamoto Masahiro Kuroda Katsuyoshi Sakae Mitsuharu Shimizu Harutaka Niiya Yoshihiro Takeda Ikuo Joja Yoshio Hiraki Shoji Kawasaki Epinephrine is the most widely used vasoconstrictive drug. However, its radioprotective potential has not yet been studied for radiation-induced mucositis and dermatitis. Other vasoconstrictive drugs induce a radioprotective effect, but are not used because of their severe side effects. We studied the radioprotective effect of epinephrine on the oral mucosa and scalp of the mice. The radiation dose was 20Gy in a single fraction to the head of the mouse. In the group treated with epinephrine ointment, secretion from the oral cavity was slight, body wieght loss was less and hair loss was observed in fewer cases compared to those in the group without of epinephrine ointment. The mechanism is thought to be related to oxygenation. Epinephrine causes vasoconstriction, therefore the blood supply is lowered and the oxygen concentration in the tissue decline. In conclusion, epinephrine is considered to have potential as a radioprotective ointment for mucous membranes and skin. No potential conflict of interest relevant to this article was reported.

Acta Medica Okayama 1985 脂質過酸化反応に対するセファランチンの影響について EN No potential conflict of interest relevant to this article was reported.