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Shikata, Kenichi Center for Innovative Clinical Medicine, Okayama University Hospital ORCID Kaken ID publons researchmap
Kodera, Ryo The Japan Diabetes Society Kaken ID researchmap
Utsunomiya, Kazunori The Japan Diabetes Society
Koya, Daisuke The Japan Diabetes Society
Nishimura, Rimei The Japan Diabetes Society
Miyamoto, Satoshi Center for Innovative Clinical Medicine, Okayama University Hospital Kaken ID
Tajima, Naoko The Japan Diabetes Society
the JDCP study group
Abstract
Aims/Introduction
To clarify the prevalence of albuminuria and renal dysfunction, and related factors in Japanese patients with diabetes, we analyzed the baseline data of the Japan Diabetes Complication and its Prevention prospective study.
Materials and Methods
We used the data of 355 patients with type 1 diabetes and 5,194 patients with type 2 diabetes to evaluate the prevalence of albuminuria and renal dysfunction, and related factors. A binomial logistic regression analysis was used to investigate independent contributing factors for estimated glomerular filtration rate <60 mL/min/1.73 m2 or albuminuria.
Results
The prevalence of microalbuminuria and macroalbuminuria was 15.2% (54/355) and 3.1% (11/355) in type 1 diabetes patients, and 25.0% (1,298/5,194) and 5.1% (265/5,194) in type 2 diabetes patients, respectively. The proportion of renal dysfunction (estimated glomerular filtration rate <60 mL/min/1.73 m2) was 9.9% (35/355) in type 1 diabetes patients, and 15.3% (797/5,194) in type 2 diabetes patients. The proportion of patients with renal dysfunction with normoalbuminuria was 7.3% (26/355) for type 1 diabetes patients, and 9.0% (467/5,194) for type 2 diabetes patients. The factors related to albuminuria in type 2 diabetes patients were glycated hemoglobin, hypertension, age, duration of diabetes, body mass index and estimated glomerular filtration rate. In contrast, factors to related renal dysfunction were age, duration of diabetes, dyslipidemia, hypertension, body mass index, male sex and albuminuria.
Conclusions
We showed the recent prevalence of albuminuria and renal dysfunction, and related factors in Japanese type 1 and type 2 diabetes patients using the baseline data of the Japan Diabetes Complication and its Prevention prospective study. The current results suggest that renal disease in patients with type 2 diabetes is heterogeneous, and different mechanisms might be involved in albuminuria and deterioration of renal function.
Keywords
Diabetic nephropathy
Diabetic kidney disease
Japan Diabetes Complication and its Prevention study
Published Date
2020-05-17
Publication Title
Journal of Diabetes Investigation
Volume
volume11
Issue
issue2
Publisher
Wiley
Start Page
325
End Page
332
ISSN
2040-1116
NCID
AA12488319
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
© 2019 The Authors.
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publisher
PubMed ID
DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1111/jdi.13116
License
https://creativecommons.org/licenses/by-nc/4.0/