このエントリーをはてなブックマークに追加
ID 61906
JaLCDOI
FullText URL
75_2_231.pdf 13.4 MB
Author
Endo, Motochika Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Yano, Shuya Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Asano, Hiroaki Department of Surgery, Mitoyo general Hospital
Takeda, Sho Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Hamada, Yuki Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kondo, Yoshitaka Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Kuroda, Shinji Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID researchmap
Shigeyasu, Kunitoshi Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Kikuchi, Satoru Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID
Tanaka, Takehiro Department of Pathology, Okayama University Hospital ORCID Kaken ID publons
Teraishi, Fuminori Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nishizaki, Masahiko Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID publons
Kagawa, Shunsuke Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Fujiwara, Toshiyoshi Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ORCID Kaken ID publons researchmap
Abstract
Targeted therapies for malignant melanoma have improved patients’ prognoses. A primary gastrointestinal malignant melanoma is very rare, with no standard treatment strategy. We treated a 78-year-old Japanese female with advanced primary gastrointestinal melanoma of the descending colon and gallbladder. We administered a multidisciplinary treatment: surgical resection of the descending colon and gallbladder tumors, resection of the metastatic lymph nodes behind the pancreas head, and immune checkpoint antibody-blockade therapy (nivolumab) for ~4 years. PET/CT demonstrated no recurrent lesion for > 3 years. Multidisciplinary therapies (e.g., surgery, chemotherapy, radiotherapy, target therapy, and immune checkpoint antibody-blockade therapy) can successfully treat primary gastrointestinal malignant melanoma.
Keywords
primary gastrointestinal melanoma
laparoscopic surgery
immune checkpoint antibody-blockade inhibitor
Amo Type
Case Report
Published Date
2021-04
Publication Title
Acta Medica Okayama
Volume
volume75
Issue
issue2
Publisher
Okayama University Medical School
Start Page
231
End Page
238
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2021 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
NAID
reference
Khalid U, Saleem T, Imam AM and Khan MR: Pathogenesis, diagnosis and management of primary melanoma of the colon. World J Surg Oncol (2011) 9: 14.
Mihajlovic M, Vlajkovic S, Jovanovic P and Stefanovic, V: Primary mucosal melanomas: a comprehensive review. Int J Clin Exp Pathol (2012) 5: 739-753.
Blecker D, Abraham S, Furth EE and Kochman ML: Melanoma in the gastrointestinal tract. Am J Gastroenterol (1999) 94: 3427- 3433.
Schuchter LM, Green R and Fraker D: Primary and metastatic diseases in malignant melanoma of the gastrointestinal tract. Curr Opin Oncol (2000)12: 181-185.
Serin G, Doganavsargil B, Caliskan C, Akalin T, Sezak M and Tuncyurek M: Colonic malignant melanoma, primary or metastatic? Case report. Turk J Gastroenterol (2010) 21: 45-49.
Tomioka K, Ojima H, Sohda M, Tanabe A, Fukai Y, Sano A, Fukuda T and Murakami M: Primary malignant melanoma of the rectum: report of two cases. Case Rep Surg (2012) 2012: 1-4.
Kenney B, Dotto J, Homer R, Shafi N and Davydova L: Primary malignant melanoma of the transverse colon: report of a case and review of the literature. Int J Surg Pathol (2007) 15: 401-407.
Poggi SH, Madison JF, Hwu WJ, Bayer S and Salem RR: Colonic melanoma, primary or regressed primary. J Clin Gastroenterol (2000) 30: 441-444.
Miliaras S, Ziogas IA, Mylonas KS and Papadopoulos VN: Primary malignant melanoma of the ascending colon. BMJ Case Rep (2018) doi:10.1136/bcr-2017-223282.
Raja J, Hegde R, Srodon M, Katoch A, Kurtzman S and Zhang Z: A case of Primary Melanoma of the Transverse Colon. Cureus (2017) 9: e1803.
Avital S, romaguera RL, Sands L, Marchetti F and Hellinger MD: Primary malignant melanoma of the right colon. Am Surg (2004) 70: 649-651.
McNicol FJ and Jones LS: Primary malignant melanoma of the colon in an oculocutaneous albino. Surgeon (2005) 3: 358-359.
Tak AM: Metastatic melanoma: a case of unknown site of primary origin. Internet J Gastroenterol (2006).
Mori D, Satoh T, Nakafusa Y, Tanaka M, Miyazaki K and Tokunaga O: Primary colonic malignant melanoma. Pathol Int (2006) 56: 744-748.
Mandot A, Kazi K, Gupta T, Desai D, Abraham P and Joshi A: Primary malignant melanoma of right colon. Indian J Gastroenterol (2006) 25: 96-97.
De palma GD and Persico G: Primary malignant melanoma of the right colon. Clin Gastroenterol Hepatol (2007) 5: a28.
Takahashi-Monroy T, Vergara-Fernandez O, Aviles A, Morales JM, Gatica E and Suarez E: Primary melanoma of the colon presenting as ileocecal intussusception. Am J Gastroenterol (2006) 101: 676-677.
Sashiyama H, Tsujinaka Y, Hamahata Y, Tsutsumi O, Hoshino T, Minami Y, Tsunoda Y, Yano M and Sato Y: Primary amelanotic malignant melanoma of the colon. Endoscopy (2010) 42: e163- 164.
Busuttil G, Blazic I, Caruana DG, Agius J and Babic D: Primary melanoma of the right colon presenting with gastrointestinal bleeding. Open Gastroenterology Journal (2013) 1: 1-3.
Li WX, Wei Y, Jiang Y, Liu YL, Ren L, Zhong YS, Ye LC, Zhu DX, Niu WX, Qin XY and Xu JM: Primary colonic melanoma presenting as ileocecal intussusception: case report and literature review. World J Gastroenterol (2014) 20: 9626-9630.
Furudoï A, Caumont C, Dutriaux C, Cappellen D, Goussot JC, Vergier B, Merlio C, Barberis C, Merlio JP and Gros A: Primary digestive melanoma in association with tubular adenoma: a case report illustrating the distinction from metastatic colonic melanoma. Hum Pathol (2016) 48: 167-171.
Larkin JV, Chiarion-Sileni V, Gonzalez R, Grob JJ, Rutkowski P, Lao CD, Cowey CL, Schadendorf D, Wagstaff J, Dummer R, Ferrucci PF, Smylie M, Hogg D, Hill A, Márquez-Rodas I, Haanen J, Guidoboni M, Maio M, Schöffski P, Carlino MS, Lebbé C, McArthur G, Ascierto PA, Daniels GA, Long GV, Bastholt L, Rizzo JI, Balogh A, Moshyk A, Hodi FS and Wolchok, JD: Five- Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma. N Engl J Med (2020) 381: 1535-1546.
Venkataraman S, Peter S and Pulimood AB: Colonic malignant melanoma mimicking colon carcinoma. Digestive Endoscopy (2004) 16: 266-268.
Bacchi CE, Boneth F, Pea M, Martignoni G and Gown AM: HMB- 45: a review. Appl Immunohistochem (1996) 4: 73-85.
Hassan I, You YN, Dozois EJ, Shayyan R, Smyrk TC, Okuno SH and Donohue JH: Clinical, pathologic, and immunohistochemical characteristics of gastrointestinal stromal tumors of the colon and rectum: implications for surgical management and adjuvant therapies. Dis Colon Rectum (2006) 49: 609-615.
Miettinen M and Lasota J: Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. Pol J Pathol (2003) 54: 3-24.
Rosai J: Rosai and Ackermanʼs Surgical Pathology. Edinburgh, Scotland: Mosby; 9 2004.
Fletcher CDM, Unni KK and Mertens F: World Health Organization: Pathology and Genetics of Tumours of Soft Tissue and Bone. Lyon, France: IARC Press; 2002.
Enzinger FM: Clear-cell sarcoma of tendons and aponeuroses. An analysis of 21 cases. Cancer (1965) 18: 1163-1174.
Hisaoka M, Ishida T, Kuo TT, Matsuyama A, Imamura T, Nishida K, Kuroda H, Inayama Y, Oshiro H, Kobayashi H, Nakajima T, Fukuda T, Ae K and Hashimoto H: Clear cell sarcoma of soft tissue: a clinicopathologic, immunohistochemical, and molecular analysis of 33 cases. Am J Surg Pathol (2008) 32: 452-460.
Stockman DL, Miettinen M, Suster S, Spagnolo D, Dominguez- Malagon H, Hornick JL, Adsay V, Chou PM, Amanuel B, Vantuinen P and Zambarano EV: Malignant gastrointestinal neuroectodermal tumor: clinicopathologic, immunohistochemical, ultrastructural, and molecular analysis of 16 cases with a reappraisal of clear cell sarcoma- like tumors of the gastrointestinal tract. Am J Surg Pathol (2012) 36: 857-868.
Zambrano E, Reyes-Mugica M, Franchi A and Rosai J: An osteoclast- rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma of soft parts: reports of 6 cases of a GIST simulator. Int J Surg Pathol (2003) 11: 75-81.
Digestive system tumours (World Health Organization Classification of Tumors). (2019) WHO classification of Tumours Editorial Board.
Jones RL, Constantinidou A, Thway K, Ashley S, Scurr M, Al-Muderis O, Fisher C, Antonescu CR, DʼAdamo DR, Keohan, LM, Maki RG and Judson IR: Chemotherapy in clear cell sarcoma. Med Oncol (2011) 28: 859-863.
Thway K and Fisher C: Tumors with EWSR1-CREB1 and EWSR1- ATF1 fusions: the current status. Am J Surg Pathol (2012) 36: e1-e11.
Özdemir N, Cangir AK, Kutlay H and Yavuzer S: Primary malignant melanoma of the lung in oculocutaneous albino patient. Eur J Cardio-Thorac (2001) 20: 864-867.
Cheung MC, Perez EA, Molina MA, Jin X, Gutierrez JC, Franceschi D, Livingstone AS and Koniaris LG: Defining the role of surgery for primary gastrointestinal tract melanoma. J Gastrointest Surg (2008)12: 731-738.
Park JH, Park HC, Park SC, Sohn DK, Oh JH, Kang SB, Heo SC, Kim MJ, Park JW, Jeong SY and Park KJ: SEoul COlorectal research Group (SECOG). Laparoscopic approach for left-sided T4 colon cancer is a safe and feasible procedure, compared to open surgery. Surg Endosc (2019) 33: 2834-2849.
Swaid F, Sroka G, Madi H, Shteinberg D, Somri M and Matter I: Totally laparoscopic versus laparoscopic-assisted left colectomy for cancer: a retrospective review. Surg Endosc (2016) 30: 2481- 2488.