Kiura, Katsuyuki - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Neuropeptide Y Antagonizes Development of Pulmonary Fibrosis through IL-1β Inhibition

FullText URL	fulltext20221223-3.pdf NA_Itano_Fig.pdf supl20221223-3.pdf NA_Itano_Supl.pdf
Author	Itano, Junko\| Taniguchi, Akihiko\| Senoo, Satoru\| Asada, Noboru\| Gion, Yuka\| Egusa, Yuria\| Guo, Lili\| Oda, Naohiro\| Araki, Kota\| Sato, Yasuharu\| Toyooka, Shinichi\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Miyahara, Nobuaki\|
Keywords	idiopathic pulmonary fibrosis NPY IL-1 beta; bleomycin bronchial epithelial cells
Note	Originally Published in:Itano J, Taniguchi A, Senoo S, Asada N, Gion Y, Egusa Y, Guo L, Oda N, Araki K, Sato Y, Toyooka S, Kiura K, Maeda Y, Miyahara N. Neuropeptide Y Antagonizes Development of Pulmonary Fibrosis through IL-1β Inhibition. Am J Respir Cell Mol Biol. 2022 Dec;67(6):654-665. DOI: 10.1165/rcmb.2021-0542OC Copyright © 2022 by the American Thoracic Society The final publication is available at https://doi.org/10.1165/rcmb.2021-0542OC \| This full-text will be available in Dec. 2023.\|
Published Date	2022-12
Publication Title	American Journal of Respiratory Cell and Molecular Biology
Volume	volume67
Issue	issue6
Publisher	American Thoracic Society
Start Page	654
End Page	665
ISSN	1044-1549
NCID	AA10707251
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 by the American Thoracic Society
File Version	author
PubMed ID	36122332
DOI	10.1165/rcmb.2021-0542oc
Web of Science KeyUT	000891796900010
Related Url	isVersionOf https://doi.org/10.1165/rcmb.2021-0542oc

Successful and Prompt Treatment with Tepotinib for Lung Adenocarcinoma Harboring MET Exon 14 Skipping Mutation Combined with Lung Abscess Formation: A Case Report

FullText URL	fulltext.pdf
Author	Makimoto, Go\| Shimonishi, Atsushi\| Ohashi, Kadoaki\| Ninomiya, Kiichiro\| Higo, Hisao\| Kato, Yuka\| Fujii, Masanori\| Kubo, Toshio\| Ichihara, Eiki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	MET Tepotinib Non-small-cell lung cancer
Published Date	2022
Publication Title	Case Reports In Oncology
Volume	volume15
Issue	issue2
Publisher	Karger
Start Page	494
End Page	498
ISSN	1662-6575
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Author(s).
File Version	publisher
PubMed ID	35702678
DOI	10.1159/000524326
Web of Science KeyUT	000864085100005
Related Url	isVersionOf https://doi.org/10.1159/000524326

Dasatinib-induced massive left chylothorax in a patient with chronic myeloid leukemia

FullText URL	fulltext.pdf
Author	Makimoto, Go\| Misawa, Mahito\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	Chronic myeloid leukemia Chylothorax Dasatinib
Published Date	2022
Publication Title	Respiratory Medicine Case Reports
Volume	volume37
Publisher	Elsevier
Start Page	101662
ISSN	2213-0071
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Authors.
File Version	publisher
PubMed ID	35585905
DOI	10.1016/j.rmcr.2022.101662
Web of Science KeyUT	000807403400006
Related Url	isVersionOf https://doi.org/10.1016/j.rmcr.2022.101662

Transformed diffuse large B-cell lymphoma from marginal zone lymphoma in the anterior mediastinum: A case report and review of the literature

FullText URL	fulltext.pdf
Author	Kitamura, Wataru\| Asada, Noboru\| Tabata, Tetsuya\| Shibata, Rei\| Nishi, Tatsuya\| Kato, Yuka\| Takasuka, Hiroki\| Fujiwara, Hideaki\| Ennishi, Daisuke\| Nishimori, Hisakazu\| Fujii, Nobuharu\| Matsuoka, Ken-Ichi\| Kiura, Katsuyuki\| Yoshino, Tadashi\| Maeda, Yoshinobu\|
Keywords	marginal zone lymphoma diffuse large B-cell lymphoma anterior mediastinum cystic lesions
Published Date	2022
Publication Title	Journal Of Clinical And Experimental Hematopatholo
Volume	volume62
Issue	issue1
Publisher	The Japanese Society for Lymphoreticular Tissue Research
Start Page	35
End Page	40
ISSN	1346-4280
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Japanese Society for Lymphoreticular Tissue Research
File Version	publisher
PubMed ID	34840205
DOI	10.3960/jslrt.21010
Web of Science KeyUT	000766876600003
Related Url	isVersionOf https://doi.org/10.3960/jslrt.21010

Pulmonary Aspergilloma and Allergic Bronchopulmonary Aspergillosis Following the 2018 Heavy Rain Event in Western Japan

FullText URL	fulltext.pdf
Author	Ando, Eri\| Nakasuka, Takamasa\| Kubo, Toshio\| Taniguchi, Akihiko\| Ninomiya, Kiichiro\| Kato, Yuka\| Ichihara, Eiki\| Ohashi, Kadoaki\| Rai, Kammei\| Hotta, Katsuyuki\| Yamane, Masaomi\| Miyahara, Nobuaki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	pulmonary aspergilloma allergic bronchopulmonary aspergillosis disaster
Published Date	2022-02-01
Publication Title	Internal Medicine
Volume	volume61
Issue	issue3
Publisher	JAPAN SOC INTERNAL MEDICINE
Start Page	379
End Page	383
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	34373373
DOI	10.2169/internalmedicine.7124-21
Web of Science KeyUT	000752787300015
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.7124-21

Identification of targetable kinases in idiopathic pulmonary fibrosis

FullText URL	fulltext.pdf
Author	Higo, Hisao\| Ohashi, Kadoaki\| Tomida, Shuta\| Okawa, Sachi\| Yamamoto, Hiromasa\| Sugimoto, Seiichiro\| Senoo, Satoru\| Makimoto, Go\| Ninomiya, Kiichiro\| Nakasuka, Takamasa\| Nishii, Kazuya\| Taniguchi, Akihiko\| Kubo, Toshio\| Ichihara, Eiki\| Hotta, Katsuyuki\| Miyahara, Nobuaki\| Maeda, Yoshinobu\| Toyooka, Shinichi\| Kiura, Katsuyuki\|
Keywords	Idiopathic pulmonary fibrosis RNA sequencing Molecular therapeutic target Personalized therapy
Published Date	2022-02-07
Publication Title	Respiratory Research
Volume	volume23
Issue	issue1
Publisher	BMC
Start Page	20
ISSN	1465-993X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2022.
File Version	publisher
PubMed ID	35130915
DOI	10.1186/s12931-022-01940-y
Web of Science KeyUT	000752386100002
Related Url	isVersionOf https://doi.org/10.1186/s12931-022-01940-y

Dramatic Response to Carboplatin Plus Paclitaxel in Pancreatic Mucinous Cystadenocarcinoma with Liver Metastasis

FullText URL	fulltext.pdf
Author	Oda, Naohiro\| Tabata, Masahiro\| Uno, Masatoshi\| Umeda, Yuzo\| Kato, Hironari\| Kubo, Toshio\| Senoo, Satoru\| Yagi, Takahito\| Fujiwara, Toshiyoshi\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	pancreas mucinous cystadenocarcinoma carboplatin paclitaxel
Published Date	2021-09-15
Publication Title	Internal Medicine
Volume	volume60
Issue	issue18
Publisher	The Japanese Society of Internal Medicine
Start Page	2967
End Page	2971
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	33814494
DOI	10.2169/internalmedicine.6730-20
Web of Science KeyUT	000697279400013
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.6730-20

Marginal Zone Lymphoma and Lung Adenocarcinoma with an EGFR Exon 19 E746-S752del Mutation in a Patient with IgG4-related Disease

FullText URL	fulltext.pdf
Author	Okawa, Sachi\| Rai, Kammei\| Fujii, Nobuharu\| Gion, Yuka\| Ninomiya, Kiichiro\| Kato, Yuka\| Taniguchi, Akihiko\| Kubo, Toshio\| Ichihara, Eiki\| Ohashi, Kadoaki\| Miyahara, Nobuaki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	EGFR IgG4-related disease marginal zone lymphoma osimertinib
Published Date	2021-09-01
Publication Title	Internal Medicine
Volume	volume60
Issue	issue17
Publisher	The Japanese Society of Internal Medicine
Start Page	2831
End Page	2837
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	33775999
DOI	10.2169/internalmedicine.6470-20
Web of Science KeyUT	000695856000020
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.6470-20

Triple therapy with osimertinib, bevacizumab and cetuximab in EGFR‑mutant lung cancer with HIF‑1α/TGF‑α expression

FullText URL	fulltext20210810-3.pdf
Author	Nishii, Kazuya\| Ohashi, Kadoaki\| Watanabe, Hiromi\| Makimoto, Go\| Nakasuka, Takamasa\| Higo, Hisao\| Ninomiya, Kiichiro\| Kato, Yuka\| Kubo, Toshio\| Rai, Kammei\| Ichihara, Eiki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	epidermal growth factor receptor osimertinib bevacizumab cetuximab hypoxia‑inducible factor‑1α transforming growth factor‑α
Published Date	2021-7-7
Publication Title	Oncology Letters
Volume	volume22
Issue	issue3
Publisher	Spandidos Publications
Start Page	639
ISSN	1792-1074
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© Nishii et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
File Version	publisher
DOI	10.3892/ol.2021.12900
Web of Science KeyUT	000678494600001
Related Url	isVersionOf https://doi.org/10.3892/ol.2021.12900

Sarcopenia is associated with poor prognosis after chemoradiotherapy in patients with stage III non-small-cell lung cancer: a retrospective analysis

FullText URL	fulltext.pdf
Author	Katsui, Kuniaki\| Ogata, Takeshi\| Sugiyama, Soichi\| Yoshio, Kotaro\| Kuroda, Masahiro\| Hiraki, Takao\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Toyooka, Shinichi\| Kanazawa, Susumu\|
Published Date	2021-06-04
Publication Title	scientific reports
Volume	volume11
Issue	issue1
Publisher	Nature Research
Start Page	11882
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021
File Version	publisher
PubMed ID	34088965
DOI	10.1038/s41598-021-91449-z
Web of Science KeyUT	000678611200010
Related Url	isVersionOf https://doi.org/10.1038/s41598-021-91449-z

第61回日本肺癌学会学術集会 “肺癌撲滅を目指して2020”

Title Alternative	The 61st Annual Meeting of the Japan Lung Cancer Society: Eradication of lung cancer 2020
FullText URL	133_80.pdf
Author	Kiura, Katsuyuki\|
Publication Title	Journal of Okayama Medical Association
Published Date	2021-04-01
Volume	volume133
Issue	issue1
Start Page	80
End Page	82
ISSN	0030-1558
Related Url	isVersionOf https://doi.org/10.4044/joma.133.80
language	Japanese
Copyright Holders	Copyright (c) 2021 岡山医学会
File Version	publisher
DOI	10.4044/joma.133.80
NAID	130008034816

VEGFR2 blockade augments the effects of tyrosine kinase inhibitors by inhibiting angiogenesis and oncogenic signaling in oncogene-driven non-small-cell lung cancers

FullText URL	fulltext.pdf
Author	Watanabe, Hiromi\| Ichihara, Eiki\| Kayatani, Hiroe\| Makimoto, Go\| Ninomiya, Kiichiro\| Nishii, Kazuya\| Higo, Hisao\| Ando, Chihiro\| Okawa, Sachi\| Nakasuka, Takamasa\| Kano, Hirohisa\| Hara, Naofumi\| Hirabae, Atsuko\| Kato, Yuka\| Ninomiya, Takashi\| Kubo, Toshio\| Rai, Kammei\| Ohashi, Kadoaki\| Hotta, Katsuyuki\| Tabata, Masahiro\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Published Date	2021-01-07
Publication Title	Cancer science
Publisher	Wiley
ISSN	1347-9032
NCID	AA11808050
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Authors.
File Version	publisher
PubMed ID	33410241
DOI	10.1111/cas.14801
NAID	120007008532
Web of Science KeyUT	000630136900001
Related Url	isVersionOf https://doi.org/10.1111/cas.14801

Lung stereotactic body radiation therapy for elderly patients aged >= 80 years with pathologically proven early-stage non-small cell lung cancer: a retrospective cohort study

FullText URL	fulltext.pdf
Author	Watanabe, Kenta\| Katsui, Kuniaki\| Sugiyama, Soichiro\| Yoshio, Kotaro\| Kuroda, Masahiro\| Hiraki, Takao\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Toyooka, Shinichi\| Kanazawa, Susumu\|
Keywords	Clinical pathology Elderly Non-small cell lung carcinoma Radiosurgery Stereotactic body radiation therapy
Published Date	2021-02-23
Publication Title	Radiation Oncology
Volume	volume16
Issue	issue1
Publisher	BMC
Start Page	39
ISSN	1748-717X
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2021.
File Version	publisher
PubMed ID	33622369
DOI	10.1186/s13014-021-01769-7
Web of Science KeyUT	000623175000001
Related Url	isVersionOf https://doi.org/10.1186/s13014-021-01769-7

Volumetric PET Parameters Predict Prognosis after Definitive Chemoradiotherapy with Cisplatin/Docetaxel for Stage III Non-Small Cell Lung Cancer

JaLCDOI	10.18926/AMO/61429
FullText URL	75_1_15.pdf
Author	Katsui, Kuniaki\| Ogata, Takeshi\| Tada, Akihiro\| Sugiyama, Soichi\| Yoshio, Kotaro\| Kuroda, Masahiro\| Kiura, Katsuyuki\| Maeda, Yoshinobu\| Toyooka, Shinichi\| Hiraki, Takao\| Kanazawa, Susumu\|
Abstract	The aim of this study was to investigate whether volumetric positron emission tomography (PET) parameters are prognostic predictors in stage III non-small cell lung cancer patients receiving definitive concurrent chemo-radiotherapy (CCRT) with cisplatin/docetaxel. Cases involving definitive CCRT were reviewed retrospectively, and the maximum standardized uptake value, metabolic tumor volume (MTV) and total lesion glycolysis (TLG) were calculated. The relationships between these PET parameters and prognosis were analyzed. MTV and TLG were significant predictors of distant metastasis-free survival (DMFS) (p = 0.0003 and 0.0005, respectively) and progression-free survival (PFS) (p = 0.001 and 0.0007, respectively). The three-year DMFS rates in patients with low and high MTV were 13.3% and 64.6%, respectively, and the corresponding values in those with low and high TLG were 13.3% and 65.2%, respectively. The three-year PFS rates in patients with low and high MTV were 13.3% and 57.8%, respectively, and the corresponding values in patients with low and high TLG were 13.3% and 57.8%, respectively. However, MTV and TLG were not predictors of local control or overall sur-vival. We demonstrated that volumetric PET parameters were predictors of patients receiving definitive CCRT. Our findings contradict the findings of previous reports and warrant further research to validate them.
Keywords	volumetric positron emission tomography parameters distant metastasis-free survival chemoradiotherapy cisplatin/docetaxel non-small cell lung cancer
Amo Type	Original Article
Publication Title	Acta Medica Okayama
Published Date	2021-02
Volume	volume75
Issue	issue1
Publisher	Okayama University Medical School
Start Page	15
End Page	23
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2021 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	33649609

Crizotinib for recurring non-small-cell lung cancer with EML4-ALK fusion genes previously treated with alectinib: A phase II trial

FullText URL	fulltext.pdf
Author	Harada, Daijiro\| Isozaki, Hideko\| Kozuki, Toshiyuki\| Yokoyama, Toshihide\| Yoshioka, Hiroshige\| Bessho, Akihiro\| Hosokawa, Shinobu\| Takata, Ichiro\| Takigawa, Nagio\| Hotta, Katsuyuki\| Kiura, Katsuyuki\| Okayama Lung Cancer Study Group\|
Keywords	Alectinib anaplastic lymphoma kinase crizotinib drug therapy non-small cell lung carcinoma
Published Date	2021-01-20
Publication Title	Thoracic Cancer
Volume	volume12
Issue	issue5
Publisher	Wiley
Start Page	643
End Page	649
ISSN	1759-7706
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 The Authors.
File Version	publisher
PubMed ID	33470536
DOI	10.1111/1759-7714.13825
Web of Science KeyUT	000608856400001
Related Url	isVersionOf https://doi.org/10.1111/1759-7714.13825

Novel prospective umbrella-type lung cancer registry study for clarifying clinical practice patterns: CS-Lung-003 study protocol

FullText URL	fulltext.pdf
Author	Nishii, Kazuya\| Inoue, Masaaki\| Obata, Hideto\| Ueda, Yutaka\| Kozuki, Toshiyuki\| Yamasaki, Masahiro\| Moritaka, Tomonori\| Awaya, Yoshikazu\| Sugimoto, Keisuke\| Gemba, Kenichi\| Kuyama, Shoichi\| Ichikawa, Hirohisa\| Shibayama, Takuo\| Kubota, Tetsuya\| Kodani, Masahiro\| Kishino, Daizo\| Fujimoto, Nobukazu\| Ishikawa, Nobuhisa\| Tsubata, Yukari\| Ishii, Tomoya\| Fujitaka, Kazunori\| Hotta, Katsuyuki\| Kiura, Katsuyuki\|
Keywords	Database observational study real world data surveillance treatment
Published Date	2021-01-12
Publication Title	Thoracic Cancer
Volume	volume12
Issue	issue5
Publisher	Wiley
Start Page	725
End Page	731
ISSN	1759-7706
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 The Authors.
File Version	publisher
PubMed ID	33434415
DOI	10.1111/1759-7714.13789
Web of Science KeyUT	000606961500001
Related Url	isVersionOf https://doi.org/10.1111/1759-7714.13789

Secondary Pulmonary Alveolar Proteinosis Associated with Primary Myelofibrosis and Ruxolitinib Treatment: An Autopsy Case

FullText URL	fulltext.pdf
Author	Sugiura, Hiroyuki\| Nishimori, Hisakazu\| Nishii, Kazuya\| Toji, Tomohiro\| Fujii, Keiko\| Fujii, Nobuharu\| Matsuoka, Ken-ichi\| Nakata, Koh\| Kiura, Katsuyuki\| Maeda, Yoshinobu\|
Keywords	pulmonary alveolar proteinosis primary myelofibrosis autopsy ruxolitinib
Published Date	2020-08-15
Publication Title	Internal Medicine
Volume	volume59
Issue	issue16
Start Page	2023
End Page	2028
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	32448830
DOI	10.2169/internalmedicine.4082-19
Web of Science KeyUT	000563078400014
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.4082-19

Managing Lung Cancer with Comorbid Interstitial Pneumonia

FullText URL	fulltext.pdf
Author	Ichihara, Eiki\| Miyahara, Nobuaki\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	lung cancer interstitial pneumonia
Published Date	2020-01-15
Publication Title	Internal Medicine
Volume	volume59
Issue	issue2
Publisher	日本内科学会
Start Page	163
End Page	167
ISSN	0918-2918
NCID	AA10827774
Content Type	Journal Article
language	English
Copyright Holders	© 2020 by The Japanese Society of Internal Medicine
File Version	publisher
PubMed ID	31534086
DOI	10.2169/internalmedicine.3481-19
NAID	130007785095
Web of Science KeyUT	000507577600002
Related Url	isVersionOf https://doi.org/10.2169/internalmedicine.3481-19

Detection of epidermal growth factor receptor mutations in exhaled breath condensate using droplet digital polymerase chain reaction

FullText URL	fulltext.pdf
Author	Nishii, Kazuya\| Ohashi, Kadoaki\| Tamura, Tomoki\| Ninomiya, Kiichiro\| Matsubara, Takehiro\| Senoo, Satoru\| Kano, Hirohisa\| Watanabe, Hiromi\| Oda, Naohiro\| Makimoto, Go\| Higo, Hisao\| Kato, Yuka\| Ninomiya, Takashi\| Kubo, Toshio\| Yamamoto, Hiromasa \| Tomida, Shuta\| Hotta, Katsuyuki\| Tabata, Masahiro\| Toyooka, Shinichi\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Keywords	non-small cell lung cancer epidermal growth factor receptor mutations droplet digital PCR exhaled breath condensate EGFR-TKIs
Published Date	2020-12
Publication Title	Oncology Letters
Volume	volume20
Issue	issue6
Publisher	Spandidos Publications
Start Page	393
ISSN	1792-1074
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
File Version	publisher
PubMed ID	33193853
DOI	10.3892/ol.2020.12256
Web of Science KeyUT	000595649300005
Related Url	isVersionOf https://doi.org/10.3892/ol.2020.12256

Rapid Disease Progression of Advanced Non-small Cell Lung Cancer Five Months after Cessation of Pembrolizumab

JaLCDOI	10.18926/AMO/60802
FullText URL	74_5_423.pdf
Author	Hirabae, Atsuko\| Ichihara, Eiki\| Sunami, Ryota\| Ota, Moeko\| Iwamoto, Yoshitaka\| Maeda, Yoshinobu\| Kiura, Katsuyuki\|
Abstract	We report a case of late-onset hyperprogressive disease after cessation of a PD-1 inhibitor. A male was diagnosed with metastatic lung adenocarcinoma with little progression for 2 months before treatment. He received pembrolizumab as a second-line treatment and was subsequently prescribed docetaxel for 3 months until a slight increase in pleural effusion. At the time of progression to docetaxel, he commenced prednisolone because of immune-system-related diarrhea. After that, his general condition rapidly worsened with severe fatigue and hypoxia. Computed tomography revealed a massive increase of pleural effusion and replacement of almost the entire liver with cancer over a period of 5 weeks.
Keywords	lung cancer immune checkpoint inhibitors pembrolizumab hyperprogression
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2020-10
Volume	volume74
Issue	issue5
Publisher	Okayama University Medical School
Start Page	423
End Page	425
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	CopyrightⒸ 2020 by Okayama University Medical School
File Version	publisher
Refereed	True
PubMed ID	33106698
Web of Science KeyUT	000581970100007
NAID	120006892928