Kin, Kyohei - OU Author List - OKAYAMA UNIVERSITY SCIENTIFIC ACHIEVEMENT REPOSITORY

Recurrence of FVIII Inhibitor during Surgery in a Patient with Severe Hemophilia A Receiving Emicizumab Prophylaxis

JaLCDOI	10.18926/AMO/69848
FullText URL	79_6_451.pdf
Author	Hagihara, Moe\| Seike, Keisuke\| Hayashino, Kenta\| Yasuhara, Takao\| Kin, Kyohei\| Hirata, Yuichi\| Kobayashi, Hiroki\| Kitamura, Wataru\| Fujiwara, Hideaki\| Asada, Noboru\| Fujii, Nobuharu\| Maeda, Yoshinobu\|
Abstract	Emicizumab, a bispecific monoclonal antibody, benefits patients with severe hemophilia A. It alters laboratory assessments of coagulation activity, requiring anti-idiotype monoclonal antibodies for accurate monitoring. A 64-year-old man, receiving emicizumab regularly, was admitted for laminoplasty. We planned to use FVIII replacement during the perioperative period after confirming the disappearance of inhibitors, monitoring coagulation activity with anti-idiotype monoclonal antibodies. Activated partial thromboplastin time was prolonged on postoperative day 2, prompting an immediate switch to eptacog alfa. The patient recovered without bleeding. This case underscores the necessity of anti-idiotype monoclonal antibodies for accurate monitoring.
Keywords	emicizumab eptacog alfa hemophilia A inhibitor anti-idiotype monoclonal antibodies to emicizumab
Amo Type	Case Report
Publication Title	Acta Medica Okayama
Published Date	2025-12
Volume	volume79
Issue	issue6
Publisher	Okayama University Medical School
Start Page	451
End Page	455
ISSN	0386-300X
NCID	AA00508441
Content Type	Journal Article
language	English
Copyright Holders	Copyright Ⓒ 2025 by Okayama University Medical School
File Version	publisher
Refereed	True

Long intervals between repetitive concussions reduce risk of cognitive impairment and limit microglial activation, astrogliosis, and tauopathy in adolescent rats

FullText URL	fulltext.pdf
Author	Hirata, Yuichi\| Kin, Kyohei\| Nagase, Takayuki\| Sasaki, Tatsuya\| Sasada, Susumu\| Sugahara, Chiaki\| Hirayama, Takahiro\| Kawai, Koji\| Tanimoto, Shun\| Miyake, Hayato\| Saijo, Tomoya\| Naito, Hiromichi\| Masai, Kaori\| Yasuhara, Takao\| Tanaka, Shota\|
Keywords	Concussion Return to play Sports-related head injury Microglia Astrocyte Tauopathy
Published Date	2025-11-18
Publication Title	Scientific Reports
Volume	volume15
Issue	issue1
Publisher	Springer Science and Business Media LLC
Start Page	40522
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2025
File Version	publisher
PubMed ID	41254121
DOI	10.1038/s41598-025-24376-y
Web of Science KeyUT	001618576200030
Related Url	isVersionOf https://doi.org/10.1038/s41598-025-24376-y

Therapeutic effects of intracerebral transplantation of human modified bone marrow-derived stromal cells (SB623) with voluntary and forced exercise in a rat model of ischemic stroke

FullText URL	fulltext.pdf
Author	Nagase, Takayuki\| Yasuhara, Takao\| Kin, Kyohei\| Sasada, Susumu\| Kawauchi, Satoshi\| Yabuno, Satoru\| Sugahara, Chiaki\| Hirata, Yuichi\| Miyake, Hayato\| Sasaki, Tatsuya\| Kawai, Koji\| Tanimoto, Shun\| Saijo, Tomoya\| Tanaka, Shota\|
Keywords	Ischemic stroke Post-stroke depression Regenerative medicine Rehabilitation SB623
Published Date	2025-04
Publication Title	Experimental Neurology
Volume	volume386
Publisher	Elsevier BV
Start Page	115145
ISSN	0014-4886
NCID	AA00641190
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2025 The Authors.
File Version	publisher
PubMed ID	39805465
DOI	10.1016/j.expneurol.2025.115145
Web of Science KeyUT	001405241700001
Related Url	isVersionOf https://doi.org/10.1016/j.expneurol.2025.115145

Cervical spinal cord stimulation exerts anti-epileptic effects in a rat model of epileptic seizure through the suppression of CCL2-mediated cascades

FullText URL	fulltext.pdf
Author	Okazaki, Yosuke\| Sasaki, Tatsuya\| Hosomoto, Kakeru\| Tanimoto, Shun\| Kawai, Koji\| Nagase, Takayuki\| Sugahara, Chiaki\| Yabuno, Satoru\| Kin, Kyohei\| Sasada, Susumu\| Yasuhara, Takao\| Tanaka, Shota\| Date, Isao\|
Keywords	Epileptic seizure Glial cells Spinal cord stimulation C-C motif chemokine ligand 2
Note	The version of record of this article, first published in Scientific Reports, is available online at Publisher’s website: http://dx.doi.org/10.1038/s41598-024-64972-y\|
Published Date	2024-06-24
Publication Title	Scientific Reports
Volume	volume14
Issue	issue1
Publisher	Nature Portfolio
Start Page	14543
ISSN	2045-2322
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© The Author(s) 2024
File Version	publisher
PubMed ID	38914629
DOI	10.1038/s41598-024-64972-y
Web of Science KeyUT	001256850300006
Related Url	isVersionOf https://doi.org/10.1038/s41598-024-64972-y

Targeting Neurogenesis in Seeking Novel Treatments for Ischemic Stroke

FullText URL	fulltext.pdf
Author	Nagase, Takayuki\| Kin, Kyohei\| Yasuhara, Takao\|
Keywords	neurogenesis ischemic stroke cell therapy rehabilitations
Published Date	2023-10-13
Publication Title	Biomedicines
Volume	volume11
Issue	issue10
Publisher	MDPI
Start Page	2773
ISSN	2227-9059
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2023 by the authors.
File Version	publisher
PubMed ID	37893146
DOI	10.3390/biomedicines11102773
Web of Science KeyUT	001094090900001
Related Url	isVersionOf https://doi.org/10.3390/biomedicines11102773

Transplantation of modified human bone marrow-derived stromal cells affords therapeutic effects on cerebral ischemia in rats

FullText URL	fulltext.pdf
Author	Kawauchi, Satoshi\| Yasuhara, Takao\| Kin, Kyohei\| Yabuno, Satoru\| Sugahara, Chiaki\| Nagase, Takayuki\| Hosomoto, Kakeru\| Okazaki, Yosuke\| Tomita, Yousuke\| Umakoshi, Michiari\| Sasaki, Tatsuya\| Kameda, Masahiro\| Borlongan, Cesario, V\| Date, Isao\|
Keywords	bone marrow stromal cells cerebral infarction encapsulated cell transplantation middle cerebral artery occlusion model neurogenesis
Published Date	2022-08-24
Publication Title	Cns Neuroscience & Therapeutics
Publisher	Wiley
ISSN	1755-5930
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2022 The Authors.
File Version	publisher
PubMed ID	36000240
DOI	10.1111/cns.13947
Web of Science KeyUT	000846694400001
Related Url	isVersionOf https://doi.org/10.1111/cns.13947

Vagus Nerve Stimulation with Mild Stimulation Intensity Exerts Anti-Inflammatory and Neuroprotective Effects in Parkinson's Disease Model Rats

FullText URL	fulltext.pdf
Author	Kin, Ittetsu\| Sasaki, Tatsuya\| Yasuhara, Takao\| Kameda, Masahiro\| Agari, Takashi\| Okazaki, Mihoko\| Hosomoto, Kakeru\| Okazaki, Yosuke\| Yabuno, Satoru\| Kawauchi, Satoshi\| Kuwahara, Ken\| Morimoto, Jun\| Kin, Kyohei\| Umakoshi, Michiari\| Tomita, Yousuke\| Tajiri, Naoki\| Borlongan, Cesario, V\| Date, Isao\|
Keywords	anti-inflammation less invasive therapy new experimental device Parkinson's disease vagus nerve stimulation
Published Date	2021-07-07
Publication Title	Biomedicines
Volume	volume9
Issue	issue7
Publisher	MDPI
Start Page	789
ISSN	2227-9059
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2021 by the authors.
File Version	publisher
DOI	10.3390/biomedicines9070789
Web of Science KeyUT	000676794000001
Related Url	isVersionOf https://doi.org/10.3390/biomedicines9070789

Long-Term Continuous Cervical Spinal Cord Stimulation Exerts Neuroprotective Effects in Experimental Parkinson's Disease

FullText URL	fulltext.pdf
Author	Kuwahara, Ken\| Sasaki, Tatsuya\| Yasuhara, Takao\| Kameda, Masahiro\| Okazaki, Yosuke\| Hosomoto, Kakeru\| Kin, Ittetsu\| Okazaki, Mihoko\| Yabuno, Satoru\| Kawauchi, Satoshi\| Tomita, Yousuke\| Umakoshi, Michiari\| Kin, Kyohei\| Morimoto, Jun\| Lee, Jea-Young\| Tajiri, Naoki\| Borlongan, Cesar V.\| Date, Isao\|
Keywords	electrical stimulation neuroinflammation neuromodulation neuroprotection 6-hydroxydopamine
Published Date	2020-06-16
Publication Title	Frontiers in Aging Neuroscience
Volume	volume12
Publisher	Frontiers Media
Start Page	164
ISSN	1663-4365
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 Kuwahara et al.
File Version	publisher
PubMed ID	32612523
DOI	10.3389/fnagi.2020.00164
Web of Science KeyUT	000546853500001
Related Url	isVersionOf https://doi.org/10.3389/fnagi.2020.00164

Cerebellar Blood Flow and Gene Expression in Crossed Cerebellar Diaschisis after Transient Middle Cerebral Artery Occlusion in Rats

FullText URL	fulltext.pdf
Author	Kidani, Naoya\| Hishikawa, Tomohito\| Hiramatsu, Masafumi\| Nishihiro, Shingo\| Kin, Kyohei\| Takahashi, Yu\| Murai, Satoshi\| Sugiu, Kenji\| Yasuhara, Takao\| Miyazaki, Ikuko\| Asanuma, Masato\| Date, Isao\|
Keywords	apoptosis cerebral blood flow crossed cerebellar diaschisis ischemic stroke oxidative stress
Published Date	2020-06-10
Publication Title	International Journal of Molecular Sciences
Volume	volume21
Issue	issue11
Publisher	MDPI
Start Page	4137
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2020 by the authors.
File Version	publisher
PubMed ID	32531947
DOI	10.3390/ijms21114137
Web of Science KeyUT	000543400300399
Related Url	isVersionOf https://doi.org/10.3390/ijms21114137

Animal Models for Parkinson's Disease Research: Trends in the 2000s

FullText URL	fulltext.pdf
Author	Kin, Kyohei\| Yasuhara, Takao\| Kameda, Masahiro\| Date, Isao\|
Keywords	animal model alpha-synuclein DJ-1 neurotoxin Parkin Parkinson's disease pesticide PINK1 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 6-hydroxydopamine
Published Date	2019-10-30
Publication Title	International Journal of Molecular Sciences
Volume	volume20
Issue	issue21
Publisher	MDPI
Start Page	E5402
ISSN	1422-0067
Content Type	Journal Article
language	English
OAI-PMH Set	岡山大学
Copyright Holders	© 2019 by the authors.
File Version	publisher
PubMed ID	31671557
DOI	10.3390/ijms20215402
Web of Science KeyUT	000498946100160
Related Url	isVersionOf https://doi.org/10.3390/ijms20215402