| ID | 32092 |
| JaLCDOI | |
| FullText URL | |
| Author |
Araki, Hiroaki
Nagatani, Tadashi
Takao, Katsuyuki
Shibata, Kazuhiko
Gomita, Yutaka
|
| Abstract | We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression. |
| Keywords | stress
depression
imipramine
forced-swim test
animal model
|
| Amo Type | Article
|
| Publication Title |
Acta Medica Okayama
|
| Published Date | 2004-12
|
| Volume | volume58
|
| Issue | issue6
|
| Publisher | Okayama University Medical School
|
| Start Page | 271
|
| End Page | 274
|
| ISSN | 0386-300X
|
| NCID | AA00508441
|
| Content Type |
Journal Article
|
| language |
English
|
| File Version | publisher
|
| Refereed |
True
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| PubMed ID | |
| Web of Science KeyUT |
