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ID 61258
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Akagi, Satoshi Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science ORCID Kaken ID
Matsubara, Hiromi Division of Cardiology, Okayama Medical Center
Nakamura, Kazufumi Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Kaken ID publons researchmap
Oto, Takahiro Department of Organ Transplant Center, Okayama University Hospital Kaken ID publons
Ejiri, Kentaro Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science ORCID publons researchmap
Ito, Hiroshi Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science Kaken ID
Abstract
Background:The waiting period for lung transplantation (LT) is approximately 3 years in Japan. The prognosis of patients with pulmonary arterial hypertension (PAH) awaiting LT is poor without LT. Patients at the present center often survive in the long term after registration for LT. The aim of this study was to elucidate why some patients survive in the long term by investigating changes in pulmonary artery pressure (PAP) after registration, and medication used.
Methods and Results:This study involved 57 patients with PAH who were enrolled in a registry for LT at Okayama University Hospital. We divided patients into 3 groups according to outcome: LT (n=27); death without LT (n=21); and survival without LT (n=9). The median interval from PAH diagnosis to epoprostenol treatment was shorter in the survival group (58 days) than in the LT group (378 days) and death group (545 days). Eight patients in the survival group, 13 in the LT group, and 13 in the death group underwent right heart catheterization after registration. Percent change in mean PAP after registration was significantly greater in the survival group (−32%) than in the LT group (−13%) and death group (1%; P<0.01).
Conclusions:Even after LT registration, patients who received epoprostenol infusion soon after diagnosis of PAH often had marked reduction in PAP and long-term survival without LT.
Keywords
Lung transplantation
Pulmonary artery hypertension
Pulmonary artery pressure
Survival
Published Date
2020-01-24
Publication Title
Circulation Journal
Volume
volume84
Issue
issue2
Publisher
The Japanese Circulation Society
Start Page
245
End Page
251
ISSN
1346-9843
NCID
AA11591968
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
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publisher
DOI
Related Url
isVersionOf https://doi.org/10.1253/circj.CJ-19-0784
License
https://creativecommons.org/licenses/by-nc-nd/4.0/