| FullText URL | fulltext20240508-01.pdf fig1_20240508-01.pdf fig2_20240508-01.pdf |
|---|---|
| Author | Akiyama, Tomoyuki| Saigusa, Daisuke| Inoue, Takushi| Tokorodani, Chiho| Akiyama, Mari| Michiue, Rie| Mori, Atsushi| Hishinuma, Eiji| Matsukawa, Naomi| Shibata, Takashi| Tsuchiya, Hiroki| Kobayashi, Katsuhiro| |
| Keywords | Amino acids Gas chromatography Liquid chromatography Mass spectrometry New-onset epilepsy |
| Note | © 2023 The Japanese Society of Child Neurology. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/| This fulltext file will be available in Mar. 2025.| |
| Published Date | 2024-04 |
| Publication Title | Brain and Development |
| Volume | volume46 |
| Issue | issue4 |
| Publisher | Elsevier BV |
| Start Page | 180 |
| End Page | 186 |
| ISSN | 0387-7604 |
| NCID | AA00111153 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 The Japanese Society of Child Neurology. |
| File Version | author |
| PubMed ID | 38171994 |
| DOI | 10.1016/j.braindev.2023.12.004 |
| Web of Science KeyUT | 001208667900001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.braindev.2023.12.004 |
| Title Alternative | Cerebral creatine deficiency syndrome |
|---|---|
| Author | Akiyama, Tomoyuki| |
| Keywords | アルギニン：グリシンアミジノ基転移酵素 グアニジノ酢酸メチル基転位酵素 クレアチントランスポータ |
| Publication Title | Journal of Okayama Medical Association |
| Published Date | 2024-04-01 |
| Volume | volume136 |
| Issue | issue1 |
| Start Page | 26 |
| End Page | 28 |
| ISSN | 0030-1558 |
| Related Url | isVersionOf https://doi.org/10.4044/joma.136.26 |
| language | Japanese |
| Copyright Holders | Copyright (c) 2024 岡山医学会 |
| File Version | publisher |
| DOI | 10.4044/joma.136.26 |
| JaLCDOI | 10.18926/AMO/65980 |
|---|---|
| FullText URL | 77_5_561.pdf |
| Author | Tsuchiya, Hiroki| Shibata, Takashi| Sasaki, Tatsuya| Inoue, Takushi| Date, Isao| Akiyama, Tomoyuki| Kobayashi, Katsuhiro| |
| Abstract | West syndrome, an infantile developmental and epileptic encephalopathy with a deleterious impact on long-term development, requires early treatment to minimize developmental abnormality; in such cases, epilepsy surgery should be considered a powerful therapeutic option. We describe a 10-month-old female admitted with West syndrome associated with a hemispheric lesion following abusive head trauma. Her seizures were suppressed by hemispherotomy at 12 months of age, leading to developmental improvement. Surgical treatment of West syndrome following traumatic brain injury has not been reported previously but is worth considering as a treatment option, depending on patient age and brain plasticity. |
| Keywords | abusive head trauma developmental and epileptic encephalopathy epilepsy surgery epileptic spasms hemispherotomy |
| Amo Type | Case Report |
| Publication Title | Acta Medica Okayama |
| Published Date | 2023-10 |
| Volume | volume77 |
| Issue | issue5 |
| Publisher | Okayama University Medical School |
| Start Page | 561 |
| End Page | 566 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | Copyright Ⓒ 2023 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 37899268 |
| Web of Science KeyUT | 001110832700002 |
| FullText URL | fulltext20230619-03.pdf fig1_20230619-03.pdf fig2_20230619-03.pdf fig3_20230619-03.pdf suppl20230619-03.pdf |
|---|---|
| Author | Akiyama, Mari| Akiyama, Tomoyuki| Saigusa, Daisuke| Hishinuma, Eiji| Matsukawa, Naomi| Shibata, Takashi| Tsuchiya, Hiroki| Mori, Atsushi| Fujii, Yuji| Mogami, Yukiko| Tokorodani, Chiho| Kuwahara, Kozue| Numata-Uematsu, Yurika| Inoue, Kenji| Kobayashi, Katsuhiro| |
| Keywords | Amino acids Biomarkers Intractable epilepsy Ketone bodies Organic acids |
| Note | © 2023 British Epilepsy Association. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.seizure.2023.03.014.| This fulltext file will be available in Apr. 2024.| |
| Published Date | 2023-04 |
| Publication Title | Seizure |
| Volume | volume107 |
| Publisher | Elsevier BV |
| Start Page | 52 |
| End Page | 59 |
| ISSN | 1059-1311 |
| NCID | AA1091615X |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2023 British Epilepsy Association. |
| File Version | author |
| PubMed ID | 36958064 |
| DOI | 10.1016/j.seizure.2023.03.014 |
| Web of Science KeyUT | 000994635600001 |
| Related Url | isVersionOf https://doi.org/10.1016/j.seizure.2023.03.014 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Kobayashi, Katsuhiro| Shibata, Takashi| Tsuchiya, Hiroki| Akiyama, Tomoyuki| |
| Keywords | epilepsy child scalp EEG false ripple high-frequency oscillation (HFO) fast oscillation (FO) |
| Published Date | 2021-06-15 |
| Publication Title | Frontiers In Human Neuroscience |
| Volume | volume15 |
| Publisher | Frontiers Media SA |
| Start Page | 696882 |
| ISSN | 1662-5161 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2021 Kobayashi, Shibata, Tsuchiya and Akiyama. |
| File Version | publisher |
| PubMed ID | 34211382 |
| DOI | 10.3389/fnhum.2021.696882 |
| Web of Science KeyUT | 000667490200001 |
| Related Url | isVersionOf https://doi.org/10.3389/fnhum.2021.696882 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Nishizawa, Hitomi| Sato, Yoshihiko| Ishikawa, Masumi| Arakawa, Yuko| Iijima, Mari| Akiyama, Tomoyuki| Takano, Kyoko| Watanabe, Atsushi| Kosho, Tomoki| |
| Keywords | Hypophosphatasia Alkaline phosphatase Genetic disease Asfotase alfa Recombinant gene therapy Motor function |
| Published Date | 2020-12 |
| Publication Title | Molecular Genetics and Metabolism Reports |
| Volume | volume25 |
| Publisher | Elsevier |
| Start Page | 100643 |
| ISSN | 2214-4269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 The Authors. |
| File Version | publisher |
| PubMed ID | 32983894 |
| DOI | 10.1016/j.ymgmr.2020.100643 |
| Web of Science KeyUT | 000600655200010 |
| Related Url | isVersionof https://doi.org/10.1016/j.ymgmr.2020.100643 |
| FullText URL | fulltext.pdf Fig1.tif SupplementaryMaterial1.pdf SupplementaryMaterial2.pdf SupplementaryMaterial3.pdf |
|---|---|
| Author | Akiyama, Tomoyuki| Hyodo, Yuki| Hasegawa, Kosei| Oboshi, Taikan| Imai, Katsumi| Ishihara, Naoko| Dowa, Yuri| Koike, Takayoshi| Yamamoto, Toshiyuki| Shibasaki, Jun| Shimbo, Hiroko| Fukuyama, Tetsuhiro| Takano, Kyoko| Shiraku, Hiroshi| Takeshita, Saoko| Okanishi, Tohru| Baba, Shimpei| Kubota, Masaya| Hamano, Shin-ichiro| Kobayashi, Katsuhiro| |
| Keywords | ALDH7A1 PLPBP PLPHP PROSC Pyridoxal 5′-phosphate homeostasis protein deficiency Pyridoxine-dependent epilepsy |
| Note | © 2020 Elsevier Inc.. This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/.This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.pediatrneurol.2020.08.020| |
| Published Date | 2020-12 |
| Publication Title | Pediatric Neurology |
| Volume | volume113 |
| Publisher | Elsevier |
| Start Page | 33 |
| End Page | 41 |
| ISSN | 0887-8994 |
| NCID | AA10472238 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32980745 |
| DOI | 10.1016/j.pediatrneurol.2020.08.020 |
| Web of Science KeyUT | 000591640100007 |
| Related Url | isVersionOf https://doi.org/10.1016/j.pediatrneurol.2020.08.020 |
| FullText URL | BD_40_9_781_785.pdf BD_40_9_Fig.pdf |
|---|---|
| Author | Miyahara, Hiroyuki| Akiyama, Tomoyuki| Waki, Kenji| Arakaki, Yoshio| |
| Keywords | Prolonged febrile seizure Acute encephalopathy with biphasic seizures and late reduced diffusion Venous blood gas analysis Electroencephalogram Clinical characteristics Venous blood gas |
| Published Date | 2018-01-14 |
| Publication Title | Brain and Development |
| Volume | volume40 |
| Issue | issue9 |
| Publisher | Elsevier |
| Start Page | 781 |
| End Page | 785 |
| ISSN | 0387-7604 |
| NCID | AA00111153 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2018 The Japanese Society of Child Neurology |
| File Version | author |
| PubMed ID | 29866486 |
| DOI | 10.1016/j.braindev.2018.05.014 |
| Web of Science KeyUT | 000445444200007 |
| Related Url | isVersionOf https://doi.org/10.1016/j.braindev.2018.05.014 |
| FullText URL | PI_62_5_587_592.pdf PI_62_5_Fig1.tif PI_62_5_Fig2.tif |
|---|---|
| Author | Miyahara, Hiroyuki| Akiyama, Tomoyuki| Hasegawa, Kosei| Akiyama, Mari| Oka, Makio| Kobayashi, Katsuhiro| Tsukahara, Hirokazu| |
| Keywords | adrenocorticotropic hormone therapy calcium crystal renal tubular epithelial cell urinary sediment |
| Note | This is the peer reviewed version of the following article: Miyahara, Hiroyuki et.al. "Laboratory changes during adrenocorticotropic hormone therapy associated with renal calcified lesions" Pediatrics International 62(5) 587-592 (2020), which has been published in final form at https://doi.org/10.1111/ped.14158. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.| |
| Published Date | 2020-01-19 |
| Publication Title | Pediatrics International |
| Volume | volume62 |
| Issue | issue5 |
| Publisher | Wiley |
| Start Page | 587 |
| End Page | 592 |
| ISSN | 1328-8067 |
| NCID | AA11320483 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2020 Japan Pediatric Society |
| File Version | author |
| PubMed ID | 31957090 |
| DOI | 10.1111/ped.14158 |
| Web of Science KeyUT | 000536494300014 |
| Related Url | isVersionOf https://doi.org/10.1111/ped.14158 |
| FullText URL | MGM_fulltext.pdf MGM_Fig1.tif MGM_Fig2.tif MGM_Fig3.tiff MGM_SuppleFig1.tif MGM_SuppleFig2.tif |
|---|---|
| Author | Akiyama, Tomoyuki| Kubota, Takuo| Ozono, Keiichi| Michigami, Toshimi| Kobayashi, Daisuke| Takeyari, Shinji| Sugiyama, Yuichiro| Noda, Masahiro| Harada, Daisuke| Namba, Noriyuki| Suzuki, Atsushi| Utoyama, Maiko| Kitanaka, Sachiko| Uematsu, Mitsugu| Mitani, Yusuke| Matsunami, Kunihiro| Takishima, Shigeru| Ogawa, Erika| Kobayashi, Katsuhiro| |
| Keywords | Asfotase alfa Liquid chromatography Vitamin B6 Diagnostic marker Therapeutic monitoring |
| Published Date | 2018-07-17 |
| Publication Title | Molecular Genetics and Metabolism |
| Volume | volume125 |
| Issue | issue1-2 |
| Publisher | Elsevier |
| Start Page | 174 |
| End Page | 180 |
| ISSN | 10967192 |
| NCID | AA11158931 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 30049651 |
| DOI | 10.1016/j.ymgme.2018.07.006 |
| Web of Science KeyUT | 000447682900022 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ymgme.2018.07.006 |
| FullText URL | fulltext.pdf Fig1.tif Fig2.tif |
|---|---|
| Author | Akiyama, Tomoyuki| Toda, Soichiro| Kimura, Nobusuke| Mogami, Yukiko| Tokorodani, Chiho| Ito, Tomoshiro| Miyahara, Hiroyuki| Hyodo, Yuki| Kobayashi, Katsuhiro| |
| Keywords | AESD Biomarker Febrile seizure Pyridoxal 5′-phosphate Pyridoxal kinase Risk factor |
| Note | This is an Accepted Manuscript of an article published by Elsevier.| |
| Published Date | 2020-05 |
| Publication Title | Brain and Development |
| Volume | volume42 |
| Issue | issue5 |
| Publisher | Elsevier |
| Start Page | 402 |
| End Page | 407 |
| ISSN | 03877604 |
| NCID | AA00111153 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| File Version | author |
| PubMed ID | 32107100 |
| DOI | 10.1016/j.braindev.2020.02.002 |
| Web of Science KeyUT | 000527287200005 |
| Related Url | isVersionOf https://doi.org/10.1016/j.braindev.2020.02.002 |
| JaLCDOI | 10.18926/AMO/57955 |
|---|---|
| FullText URL | 74_1_65.pdf |
| Author | Akiyama, Tomoyuki| Saigusa, Daisuke| Hyodo, Yuki| Umeda, Keiko| Saijo, Reina| Koshiba, Seizo| Kobayashi, Katsuhiro| |
| Abstract | To characterize metabolic profiles within the central nervous system in epilepsy, we performed gas chromatography-tandem mass spectrometry (GC-MS/MS)-based metabolome analysis of the cerebrospinal fluid (CSF) in pediatric patients with and without epilepsy. The CSF samples obtained from 64 patients were analyzed by GC-MS/MS. Multivariate analyses were performed for two age groups, 0-5 years of age and 6-17 years of age, to elucidate the effects of epilepsy and antiepileptic drugs on the metabolites. In patients aged 0-5 years (22 patients with epilepsy, 13 without epilepsy), epilepsy patients had reduced 2-ketoglutaric acid and elevated pyridoxamine and tyrosine. In patients aged 6-17 years (12 with epilepsy, 17 without epilepsy), epilepsy patients had reduced 1,5-anhydroglucitol. Valproic acid was associated with elevated 2-aminobutyric acid, 2-ketoisocaproic acid, 4-hydroxyproline, acetylglycine, methionine, N-acetylserine, and serine. Reduced energy metabolism and alteration of vitamin B6 metabolism may play a role in epilepsy in young children. The roles of 1,5-anhydroglucitol in epilepsy in older children and in levetiracetam and zonisamide treatment remain to be explained. Valproic acid influenced the levels of amino acids and related metabolites involved in the metabolism of serine, methionine, and leucine. |
| Keywords | antiepileptic drugs gas chromatography-tandem mass spectrometry metabolome analysis metabolomics |
| Amo Type | Original Article |
| Publication Title | Acta Medica Okayama |
| Published Date | 2020-02 |
| Volume | volume74 |
| Issue | issue1 |
| Publisher | Okayama University Medical School |
| Start Page | 65 |
| End Page | 72 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| Content Type | Journal Article |
| language | English |
| Copyright Holders | CopyrightⒸ 2020 by Okayama University Medical School |
| File Version | publisher |
| Refereed | True |
| PubMed ID | 32099251 |
| Web of Science KeyUT | 000516606200010 |
| NAID | 120006795622 |
| FullText URL | fulltext.pdf |
|---|---|
| Author | Yokoi, Katsuyuki| Nakajima, Yoko| Shinkai, Yasuko| Sano, Yoshimi| Imamura, Mototaka| Akiyama, Tomoyuki| Yoshikawa, Tetsushi| Ito, Tetsuya| Kurahashi, Hiroki| |
| Keywords | ALPL Dominant-negative mutations Hypophosphatasia Premature loss of deciduous |
| Published Date | 2019-12-31 |
| Publication Title | Molecular Genetics and Metabolism Reports |
| Volume | volume21 |
| Publisher | Elsevier |
| Start Page | 100515 |
| ISSN | 22144269 |
| Content Type | Journal Article |
| language | English |
| OAI-PMH Set | 岡山大学 |
| Copyright Holders | © 2019 The Authors. Published by Elsevier Inc. |
| File Version | publisher |
| PubMed ID | 31641588 |
| DOI | 10.1016/j.ymgmr.2019.100515 |
| Web of Science KeyUT | 000500718300013 |
| Related Url | isVersionOf https://doi.org/10.1016/j.ymgmr.2019.100515 |
