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Abe, Masaya Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Asada, Noboru Department of Hematology and Oncology, Okayama University Hospital Kaken ID researchmap
Kimura, Maiko Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Fukui, Chie Division of Hematology, Department of Medicine, Kobe University Hospital
Yamada, Daisuke Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Wang, Ziyi Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Miyake, Masayuki Division of Medical Support, Okayama University Hospital
Takarada, Takeshi Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Ono, Mitsuaki Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Aoe, Michinori Division of Medical Support, Okayama University Hospital
Kitamura, Wataru Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Matsuda, Masayuki Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Moriyama, Takashi Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Matsumura, Akifumi Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Maeda, Yoshinobu Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Kaken ID researchmap
Abstract
T-cell acute leukemia and lymphoma have a poor prognosis. Although new therapeu-tic agents have been developed, their therapeutic effects are suboptimal. α- Pinene, a monoterpene compound, has an antitumor effect on solid tumors; however, few comprehensive investigations have been conducted on its impact on hematologic ma-lignancies. This report provides a comprehensive analysis of the potential benefits of using α- pinene as an antitumor agent for the treatment of T-cell tumors. We found that α- pinene inhibited the proliferation of hematologic malignancies, especially in T- cell tumor cell lines EL-4 and Molt-4, induced mitochondrial dysfunction and re-active oxygen species accumulation, and inhibited NF-κB p65 translocation into the nucleus, leading to robust apoptosis in EL-4 cells. Collectively, these findings suggest that α- pinene has potential as a therapeutic agent for T-cell malignancies, and further investigation is warranted.
Keywords
alpha-pinene
apoptosis
hematologic malignancies
lymphoblastic leukemia, acute, T-cell
T-cell lymphoma
Published Date
2024-01-26
Publication Title
Cancer Science
Volume
volume115
Issue
issue4
Publisher
Wiley
Start Page
1317
End Page
1332
ISSN
1347-9032
NCID
AA11808050
Content Type
Journal Article
language
English
OAI-PMH Set
岡山大学
Copyright Holders
© 2024 The Authors.
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publisher
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DOI
Web of Science KeyUT
Related Url
isVersionOf https://doi.org/10.1111/cas.16086
License
https://creativecommons.org/licenses/by-nc-nd/4.0/
Citation
Abe M, Asada N, Kimura M, et al. Antitumor activity of α-pinene in T-cell tumors. Cancer Sci. 2024; 115: 1317-1332. doi:10.1111/cas.16086
Funder Name
Wesco Scientific Promotion Foundation
Teraoka Scholarship Foundation