岡山実験動物研究会 Acta Medica Okayama 35 2019 裏表紙・英文目次 EN No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 組織・会則 78 79 EN No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 会員名簿 73 73 EN No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 会費に関する内規、会報投稿規程 72 72 EN No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 第75 回、第76 回研究会例会、理事会報告 59 71 EN No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 岡山実験動物研究会報第1 号から第３５号までの掲載内容 46 58 EN Katsunori Sato Department of Animal Resources, Tsushima South Laboratory, Advanced Science Research Center, Okayama University The Proceedings of the Okayama Association for Laboratory Animal Science were initially issued in 1983, the year following the establishment of the association, and No.35 is the latest.Scince issue No.2, the proceedings have consisted of the following content: <Greeting from the President>, <Summaries of Lectures (special, commemorative, and invited lectures), <Contribution>, <Introduction of Animal Research Facilities in Japan>, <Meeting Highlights>, <Member directory>, and <Organization and Rules of the Association>, in this order. Additionally, the publication of references and advertisements by supporting members recently started. Number 19 (issued in 2002) was the first to present a table of contents in English on its back cover, and this style has been maintained to date. On March 24, the president of the association and director of the Okayama University Libraries exchanged copies of an agreement regarding the registration of these contents with the Okayama University Scientific Achievement Repository (OUSAR) and other databases, providing a basis for their current registration and publication. Literature-based information is also being collected and published in databases organized by the Non-profit Organization Japan Medical Abstracts Society (Ichushi) and Japan Science & Technology Agency (JST). No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 地区研究会の活動紹介 38 45 EN わが国には現在11 の地区研究会があり、独自の活動が展開されています。本報では、各地区研究会の間での情報交換、交流などを意図して、平成30 年度の活動について北から順に紹介します。なお、会長、事務局担当者及び講演者、話題提供者の方々のお名前は敬称を省略させていただきました。詳細な内容をご希望の方は各地区研究会の事務局にお問い合わせ下さい。 No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 実験動物アレルギー予防を目指した兵庫医科大学 病態モデル研究センターの紹介 29 37 EN Eiji Sagara Center for Comparative Medicine, Hyogo College of Medicine Laboratory animal allergy (LAA) is an important problem on considering the occupational safety and health of animal workers. The Center for Comparative Medicine (CCOM), Hyogo College of Medicine, opened on April 1, 2018, is an animal experiment facility designed and constructed based on the concept of LAA prevention. This CCOM is located on the first and second floors of a newly built "education· research building". Methods for the prevention of LAA are airflow control by air conditioning equipment, breeding equipment, experimental equipment, cage transporters that suppress the diffusion of aero allergens, spraying of slightly acidic water mist, and prevention of allergen exposure by the strict use of Personal Protective Equipment (PPE). In addition, we implemented training on LAA and take measures to prevent office workers from being exposed to laboratory animal-derived allergens. No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 コモンマーモセットを育てる 26 28 EN Haruna Hashimoto Advanced Science Research Center, Okayama University In mid July 2018, the common marmoset bred in Okayama University gave birth to a triplet. It is very difficult to raise three infants. We selected the most heaviest one of her siblings, and we call her “POCKE”. We brought her up on the bottle for 80 days from the birth instead of her own mother. After 81 days, she finaly weand. Now she has become attached to human, but we hope that she gets back to their original community, as a “common” marmoset. No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 新生児マウスを用いる動物実験が母マウスにもたらすストレスの生化学的評価 22 25 EN Norio Yata Advanced Science Research Center, Okayama University Corticosterone, the glucocorticoid in rodents, is released from adrenal cortex in response to stress. Sometimes, for use in experiments, infants may be separated from their mother mouse. We studied the stress of mother mouse when she separates from infants. As a result, the concentration of corticosterone in the blood of the mother mouse tended to increase, by pulling her infants apart. In the case of using infant mice for animal experiments, it was suggested that it is necessary to consider the maternal stress. No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 母マウスが望む環境エンリッチメントとは？ : 環境エンリッチメント選びを考える 18 21 EN Sumire Ishihara Advanced Science Research Center, Okayama University Environmental enrichment, whose material is commercially available, is today thought to improve animal welfare, for instance, control of stress. There were some reports that these report contribution of suppression of stress, which the mother mice suffer during nursing their pup. However, the effects on stress-suppression by introducing the enrichment materials is unknown. In this study, determined plasma and urinary corticosterone in the mother mice with or without the materials from their making to weaning. No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 種名が不明なミズハタネズミ亜科系統の種の同定 12 17 EN Satoshi Takahata Department of Zoology, Faculty of Science, Okayama University of Science Natsumi Isemura Department of Zoology, Faculty of Science, Okayama University of Science Kazuyuki Mekada Department of Zoology, Faculty of Science, Okayama University of Science This study investigated the taxonomic status of a laboratory strain belonging to the family Arvicolinae for which the wild species name is unknown. This vole strain, though considered formerly a Lemming, was distinguishable from any Lemmus species by features of its appearance, skull and molar morphology, and conventional chromosomal pattern. Subsequently, we read the nucleotide sequence of the mitochondrial cytochrome b (Cyb) gene and constructed a molecular phylogenetic tree. We found that this vole strain belongs to the same clade as Microtus guenthe No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 分泌型免疫グロブリンA の腸内細菌への結合活性は 高脂肪食の摂取により弱まる 9 11 EN Takeshi Tsuruta Graduate school of Environmental and Life Sciences, Okayama University Teresia Aluoch MUHOMAH Graduate school of Environmental and Life Sciences, Okayama University Kei Sonoyama Research Faculty of Agriculture, Hokkaido University Naoki Nishino Graduate school of Environmental and Life Sciences, Okayama University Secretory immunoglobulin A (SIgA) is predominant antibody secreted into the gut relating to maintain gut homeostasis. In the present study, we focused on the SIgA coating of gut bacteria as a mucosal immune response affecting the gut bacteria following a high-fat diet (HFD). This study newly showed that the level of SIgA coating of gut bacteria was significantly decreased in HFD-fed mice than normal-fat diet (NFD)-fed mice. Furthermore, we found that the relative abundances of gut bacteria were significantly negatively or positively correlated with the level of SIgA coating of gut bacteria in NFD-fed and HFD-fed mice. Our observations suggest that a decrease in the level of SIgA coating of the gut bacteria through a HFD might relate to HFD-induced changes in bacterial composition. No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 色素細胞系 : 生命機能発現機構解明の１モデルシステム 2 8 EN Hiroaki Yamamoto Faculty of Bioscience Nagahama Institute of Bio-Science and Technology There are two cell lineages of mammalian melanin pigment cells, one that leads to retinal pigment epithelium (RPE) cells in the eye from the optic cup and the other leading to melanocytes from vertebrate-specific neural crest cells. Melanocyte precursors have high mobility and migrate and settle into various tissues and organs, including the skin, choroid, inner ear, heart, brain, adipose tissue, lung, etc. It is well known that RPE cells are essential for visual acuity and that melanocytes in the skin provide protection against UV-damage. So, what is the function of extracutaneous melanocytes that are distributed elsewhere in the body where only very small amounts of light illuminate their existence? Here I would like to briefly introduce our research history and then discuss the important roles of melanocytes in the inner ear that are indispensable for hearing ability and those in the choroid where they seem to contribute to maintaining the structures of their habitats. No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 会長あいさつ 1 1 EN Katsumi Mominoki Department of Animal Resources, Advanced Science Research Center, Okayama University No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 35 2019 表紙・目次 EN No potential conflict of interest relevant to this article was reported.