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ID 16285
Eprint ID
16285
FullText URL
98_501.pdf 4.53 MB
Title Alternative
Analysis of cerebrospinal fluid proteins in cerebrovascular diseases by microscale two-dimensional electrophoresis
Author
Saskurai, Hiroko
Abstract
Cerebrospinal fluid (CSF) proteins, as resolved by microscale two-dimensional electrophoresis and visualized by silver staining, were analyzed quantitatively in cerebrovascular diseases (CVD) and other neuropsychiatric diseases. Some remarkable quantitative changes in CSF proteins were observed in patients with CVD, however, no change was detected in patients with schizophrenia and epilepsy. In CVD, patterns of CSF proteins appeared to vary during the course of the disease. In the first week from the onset, three neutral proteins of similar molecular weights (Mr 43,000) were increased. In later stages, these proteins began to diminish to the previous level but several other proteins started to increase. Three of them were similar in size (Mr 37,000) and had isoelectric points (pI) slightly more acidic than albumin. Proteins of Mr 39,000-40,000 highly represented in CSF were also increased in the late stage. These proteins are enriched in human serum, as well, and have been shown to decrease in CSF from aged subjects. Another subset of proteins increased in this period were very acidic (
Keywords
脳脊髄液タンパク質
脳血管障害
二次元電気泳動
Published Date
1986-06-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume98
Issue
issue5-6
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
501
End Page
514
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/98/5-6/98_5-6_501/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
Japanese
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma