start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=5-6 article-no= start-page=577 end-page=586 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Field survey of acatalasemia and hypocatalasemia from 1949 through 1985 kn-title=昭和60年までのAcatalasemia,Hypocatalasemia調査集計 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The authors reported the results of a field survey of acatalasemia and hypocatalasemia conducted from 1949 through 1985. Six families and eleven cases of acatalasemia and twelve hypocatalasemia cases were added to the statistics reported in 1976. As a result, the total number of reported acatalasemias became 108 cases in 53 families as of the end of 1985. en-copyright= kn-copyright= en-aut-name=TakaharaShigeo en-aut-sei=Takahara en-aut-mei=Shigeo kn-aut-name=高原滋夫 kn-aut-sei=高原 kn-aut-mei=滋夫 aut-affil-num=1 ORCID= en-aut-name=OguraYoshio en-aut-sei=Ogura en-aut-mei=Yoshio kn-aut-name=小倉義郎 kn-aut-sei=小倉 kn-aut-mei=義郎 aut-affil-num=2 ORCID= en-aut-name=MasudaYu en-aut-sei=Masuda en-aut-mei=Yu kn-aut-name=増田游 kn-aut-sei=増田 kn-aut-mei=游 aut-affil-num=3 ORCID= en-aut-name=NishiokaKeiko en-aut-sei=Nishioka en-aut-mei=Keiko kn-aut-name=西岡慶子 kn-aut-sei=西岡 kn-aut-mei=慶子 aut-affil-num=4 ORCID= en-aut-name=NishizakiKazunori en-aut-sei=Nishizaki en-aut-mei=Kazunori kn-aut-name=西崎和則 kn-aut-sei=西崎 kn-aut-mei=和則 aut-affil-num=5 ORCID= en-aut-name=SugiuraTomoaki en-aut-sei=Sugiura en-aut-mei=Tomoaki kn-aut-name=杉浦友昭 kn-aut-sei=杉浦 kn-aut-mei=友昭 aut-affil-num=6 ORCID= en-aut-name=FurukawaKatsuro en-aut-sei=Furukawa en-aut-mei=Katsuro kn-aut-name=古川勝朗 kn-aut-sei=古川 kn-aut-mei=勝朗 aut-affil-num=7 ORCID= en-aut-name=MizukoYukio en-aut-sei=Mizuko en-aut-mei=Yukio kn-aut-name=水河幸夫 kn-aut-sei=水河 kn-aut-mei=幸夫 aut-affil-num=8 ORCID= en-aut-name=KurodaYasuo en-aut-sei=Kuroda en-aut-mei=Yasuo kn-aut-name=黒田泰生 kn-aut-sei=黒田 kn-aut-mei=泰生 aut-affil-num=9 ORCID= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=緒方正名 kn-aut-sei=緒方 kn-aut-mei=正名 aut-affil-num=10 ORCID= en-aut-name=OhkuraKoji en-aut-sei=Ohkura en-aut-mei=Koji kn-aut-name=大倉興司 kn-aut-sei=大倉 kn-aut-mei=興司 aut-affil-num=11 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 affil-num=11 en-affil= kn-affil=東京医科歯科大学難治疾患研究所人類遺伝学部門 END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=5-6 article-no= start-page=563 end-page=576 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on 24-hour Holter electrocardiography Part U: Pacemaker function, arrhythmias and hemodynamics of cases with permanent pacemaker implantation kn-title=24時間ホルター心電図に関する研究 第2編 人工ペースメーカーの作動状態と合併不整脈および血行動態 en-subtitle= kn-subtitle= en-abstract= kn-abstract=One hundred twenty-four patients with unipolar permanent pacemaker implantation (advanced atrioventricular block, 62 cases; sick sinus syndrome, 51 cases; and atrial fibrillation with slow ventricular response, 11 cases) were studied by 24-hour Holter electrocardiography. Analysis of pacemaker function and arrhythmias with various pacing modes (VVI pacing, 70 cases; AAI pacing, 19 cases; and DDD pacing, 35 cases) and measurement of hemodynamics revealed the following. In all pacing modes, atrial contraction was observed in cases of advanced atrioventricular block. However, in the VVI pacing mode with sick sinus syndrome, atrial contraction was often lost. In sick sinus syndrome group V, pacemaker non-mediated arrhythmias were often recorded. Pacing failure was not noted with any atrial or ventricular pacing. Undersensing was observed in 26% of the AAI pacing group and 7% of the VVI pacing group. Myopotential inhibition was observed in 11-24% of all pacing modes, but only two patients complained of subjective symptoms. DDD pacing with atrial sensing yielded effective increase of heart rate, but caused pacemaker tachycardia and pacemaker mediated tachycardia. In making these diagnosis and managing of pacemaker mediated arrhythmias, 24-hour Hotter recordings were the most effective. In comparison of hemodynamics in any pacing mode, physiological pacing was significantly different from VVI pacing as to blood pressure, left atrial pressure and cardiac index. Patients who require improvement of hemodynamics should be treated with physiological pacing. As for the optimal choice of pacing modes, patients with advanced atrioventricular block without underlying disease do not always require physiological pacing. However, the patients with sick sinus syndrome should receive physiological pacing. en-copyright= kn-copyright= en-aut-name=HataTakato en-aut-sei=Hata en-aut-mei=Takato kn-aut-name=畑隆登 kn-aut-sei=畑 kn-aut-mei=隆登 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=ホルター心電図 kn-keyword=ホルター心電図 en-keyword=ペーシングモード kn-keyword=ペーシングモード en-keyword=ペースメーカー作動状態 kn-keyword=ペースメーカー作動状態 en-keyword=ペースメーカー合併不整脈 kn-keyword=ペースメーカー合併不整脈 en-keyword=ペースメーカー血行動態 kn-keyword=ペースメーカー血行動態 END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=5-6 article-no= start-page=549 end-page=562 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on 24-hour Holter electrocardiography Part I: Bradyarrhythmias and pacemaker indication kn-title=24時間ホルター心電図に関する研究 第1編 徐脈性不整脈とペースメーカー適応 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Studies of 2216 24-hour Holter electrocardiograms of 1549 patients revealed bradyarrhythmias in 33 cases of advanced atrioventricular block, 169 cases of sick sinus symdrome and 32 cases of atrial fibrillation with slow ventricular response. The underlying diseases were mostly idiopathic, but included ischemic heart diseases and cardiomyopathy as well. The findings of Holter electrocardiography showed a significant difference between the bradyarrhythmia group and control group as to the minimum heart rate, maximum heart rate, the longest ventricular pauses and total number of QRS's during a 24-hour period. There were 55 cases of bradyarrhythmias with longest ventricular pauses of 3.0 seconds or longer. The incidence of atrial fibrillation with slow ventricular response was significantly different from other bradyarrhythmias. There were 64 cases of bradyarrhythmias with the total number of QRS's during a 24-hour period equaling 70,000 beats/day or less. The incidence of sick sinus syndrome group I was significantly different from other bradyarrhythmias. As regards severity of bradyarrhythmias, these two findings were inconsistent. Comparative studies of paced and unpaced groups showed that the patients were older and had more subjective symptoms in the paced group. In all Holter findings, the total number of QRS's during a 24-hour period and the longest ventricular pauses were significantly different from other findings. No correlation was observed between the longest ventricular pauses and the maximum sinus node recovery time (or maximum automaticity recovery time). In consideration of subjective symptoms and underlying diseases, severity and pacemaker indication of bradyarrhythmias should be determined by longest ventricular pauses and total number of QRS's during a 24-hour period shown on 24-hour Holter recordings. en-copyright= kn-copyright= en-aut-name=HataTakato en-aut-sei=Hata en-aut-mei=Takato kn-aut-name=畑隆登 kn-aut-sei=畑 kn-aut-mei=隆登 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=ホルター心電図 kn-keyword=ホルター心電図 en-keyword=徐脈性不整脈 kn-keyword=徐脈性不整脈 en-keyword=ペースメーカー適応 kn-keyword=ペースメーカー適応 en-keyword=最長RR間隔 kn-keyword=最長RR間隔 en-keyword=24時間総心拍数 kn-keyword=24時間総心拍数 END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=5-6 article-no= start-page=537 end-page=547 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on immunoglobulin receptors and the action of IgG antibody on basophils in bronchial asthmatics U. The role of IgG antibody in hyposensitization therapy kn-title=気管支喘息患者好塩基球の免疫グロブリンレセプターとIgG抗体の作用機作に関する研究 第2編 減感作療法におけるIgG抗体の役割に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The action of IgG antibody on basophils was studied during hyposensitization therapy in bronchial asthmatics. IgE and IgG antibodies bound to the surface of basophils, and the redistribution of IgE receptors were observed by immuno-scanning electron microscopy. The ratio of IgG to IgE antibodies bound to basophils increased significantly during hyposensitization therapy (p<0.01). The occurrence of cap and patch formations of IgE receptors on the surface of basophils diminished during hyposensitization therapy. The effects on the passive sensitization of basophils with IgG(4) myeloma protein were also studied in vitro. The results showed that the ratio of IgG(4) to IgE antibodies on the cell increased, and binding of anti-IgE antibody significantly diminished (p<0.01). The percent of reactive basophils decreased when anti-IgE antiserum was added. These findings indicate that IgG(4) antibodies affect the binding between IgE antibody and anti-IgE or antigens on the surface of basophils as a blocking antibody in hyposensitization therapy. en-copyright= kn-copyright= en-aut-name=MatsuokaTakashi en-aut-sei=Matsuoka en-aut-mei=Takashi kn-aut-name=松岡孝 kn-aut-sei=松岡 kn-aut-mei=孝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科学教室 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=Hyposensitization therapy kn-keyword=Hyposensitization therapy en-keyword=Basophil kn-keyword=Basophil en-keyword=IgG(4) antibody kn-keyword=IgG(4) antibody en-keyword=Blocking antibody kn-keyword=Blocking antibody END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=5-6 article-no= start-page=525 end-page=535 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on immunoglobulin receptors and the action of IgG antibody on basophils in bronchial asthmatics I. The role of IgG antibody in intractable asthma kn-title=気管支喘息患者好塩基球の免疫グロブリンレセプターとIgG抗体の作用機作に関する研究 第1編 重症難治性喘息におけるIgG抗体の役割に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To clarify the action of IgG antibody on basophils in intractable asthmatics, morphological changes, density and redistribution of IgG antibodies on basophils were observed by immunoscanning electron microscopy. Pear-shaped basophils appeared more frequently in severe asthmatics than in nonsevere asthmatics when anti-IgG was added. The density of IgG antibodies bound to basophils was significantly higher in severe, but steroid-independent, asthmatics than in non-severe asthmatics and in steroid-dependent asthmatics (p<0.001). Cap and patch formations of IgG receptors on the cell were more frequent in severe asthmatics than in non-severe asthmatics. These findings suggest that the reactivity of basophils mediated by IgG antibodies is enhanced according to the severity of asthma, indicating that IgG antibodies act as anaphylactic antibodies in severe asthmatics, although IgG antibodies bound to the cell decrease during long-term steroid therapy. en-copyright= kn-copyright= en-aut-name=MatsuokaTakashi en-aut-sei=Matsuoka en-aut-mei=Takashi kn-aut-name=松岡孝 kn-aut-sei=松岡 kn-aut-mei=孝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科学教室 en-keyword=Intractable asthma kn-keyword=Intractable asthma en-keyword=Reactive basophil kn-keyword=Reactive basophil en-keyword=IgG antibody kn-keyword=IgG antibody en-keyword=Immuno-SEM kn-keyword=Immuno-SEM END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=5-6 article-no= start-page=515 end-page=524 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A study on the factors related to birth weight in "Buraku" (socio-economically discriminated) areas in Japan kn-title=被差別部落の低体重児の発生要因に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A questionnaire study on factors related to birth weight was carried out in a "Buraku" area and control area from 1975 to 1984. Altogether, 111 births were covered in the "Buraku" area, and 309 in the control area. The incidence of low birth weight was found to be significantly higher in the "Buraku" area than in the control area. Factors related to the high incidence of low birth weight were observed more frequently in the "Buraku" area than in the control area. Among these factors, the duration of gestation, the number of days-off before delivery, and the mother's physical structure and smoking habits were found to be strongly related to the incidence of low birth weight. Such factors as the number of days-off before delivery and mother's smoking habits were also found to have a high relation to socio-economical factors: These results demonstrate that the incidence of low birth weight is significantly higher in the "Buraku" area than in the control area, and that this phenomenon is brought about by poor health of the mother and socio-economical factors. en-copyright= kn-copyright= en-aut-name=KoderaRyosei en-aut-sei=Kodera en-aut-mei=Ryosei kn-aut-name=小寺良成 kn-aut-sei=小寺 kn-aut-mei=良成 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学教室 en-keyword=被差別部落 kn-keyword=被差別部落 en-keyword=低体重児 kn-keyword=低体重児 en-keyword=低体重児出生要因 kn-keyword=低体重児出生要因 en-keyword=社会的・経済的要因 kn-keyword=社会的・経済的要因 en-keyword=疫学調査 kn-keyword=疫学調査 END start-ver=1.4 cd-journal=joma no-vol=98 cd-vols= no-issue=5-6 article-no= start-page=501 end-page=514 dt-received= dt-revised= dt-accepted= dt-pub-year=1986 dt-pub=19860630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of cerebrospinal fluid proteins in cerebrovascular diseases by microscale two-dimensional electrophoresis kn-title=脳血管障害における脳脊髄液中のタンパク質の変化 ―二次元電気泳動法による解析― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Cerebrospinal fluid (CSF) proteins, as resolved by microscale two-dimensional electrophoresis and visualized by silver staining, were analyzed quantitatively in cerebrovascular diseases (CVD) and other neuropsychiatric diseases. Some remarkable quantitative changes in CSF proteins were observed in patients with CVD, however, no change was detected in patients with schizophrenia and epilepsy. In CVD, patterns of CSF proteins appeared to vary during the course of the disease. In the first week from the onset, three neutral proteins of similar molecular weights (Mr 43,000) were increased. In later stages, these proteins began to diminish to the previous level but several other proteins started to increase. Three of them were similar in size (Mr 37,000) and had isoelectric points (pI) slightly more acidic than albumin. Proteins of Mr 39,000-40,000 highly represented in CSF were also increased in the late stage. These proteins are enriched in human serum, as well, and have been shown to decrease in CSF from aged subjects. Another subset of proteins increased in this period were very acidic (