| ID | 16630 |
| Eprint ID | 16630
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| FullText URL | |
| Title Alternative | Studies on anticancer agent-monoclonal antibody conjugates Part I. Production of anti-HLA monoclonal antibody-BLM, -MMC, -MCR conjugates and their biological activities
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| Author |
Manabe, Yuichi
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| Abstract | Bleomycin (BLM) and mitomycin C (MMC), potent anticancer agents, were linked covalently to murine monoclonal anti-HLA IgG(1) antibody (H-1) with the use of dextran T-40. Macromomycin (MCR) was coupled to H-1 in the presence of carbodiimide. H-1 alone did not inhihit cell growth. BLM-(H-1) and MMC-(H-1) conjugates showed stronger cytotoxicity to an HLA-bearing cell line than BLM and MMC, respectively. MCR-(H-1) and free MCR showed the same cytotoxicity to HLA-bearing cells, while the conjugate was less toxic than free MCR against cells lacking HLA. These results indicate that BLM-(H-1), MMC-(H-1) and MCR-(H-1) exert antibody-targeting cytotoxicity in vitro.
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| Keywords | 抗HLAモノクロナール抗体
bleomycin
mitomycin C
macromomycin
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| Published Date | 1984-12-30
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| Publication Title |
岡山医学会雑誌
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| Publication Title Alternative | Journal of Okayama Medical Association
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| Volume | volume96
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| Issue | issue11-12
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| Publisher | 岡山医学会
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| Publisher Alternative | Okayama Medical Association
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| Start Page | 1183
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| End Page | 1193
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| ISSN | 0030-1558
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| NCID | AN00032489
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| Content Type |
Journal Article
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| Official Url | https://www.jstage.jst.go.jp/article/joma1947/96/11-12/96_11-12_1183/_article/-char/ja/
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| Related Url | http://www.okayama-u.ac.jp/user/oma/index.html
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| language |
Japanese
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| Copyright Holders | 岡山医学会
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| File Version | publisher
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| Refereed |
True
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| Eprints Journal Name | joma
|
