start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1309
end-page=1317
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Evaluation of the standard total coli-form MPN test for the biological examination of water pollution
kn-title=大腸菌群測定法の水質汚染指標性の検討
en-subtitle=
kn-subtitle=
en-abstract=The standard total coli-form MPN test is widely used as a biological indicator of water pollution. But our applications of the test to various field works resulted in much higher cell numbers than be expected. The reason can be thought to be that bacteria belonging to coliform group do not always derived from human and animal feces. In order to examine this possibility, the authors carried out the isolation and identification of bacteria which were detected by this method from various kinds of specimens. The result indicated that the bacteria designated as coli-form group included not only human- and animal-derived bacteria but also bacterial species which apparently derived from plants, soil or water, e.g. Erwinia, Aeromonas, Serratia, Citrobacter and so forth. Therefore, a method is demanded by which one can estimate quantitatively only bacteria associated with human and animal feces.
kn-abstract=水質検査には化学的検査項目以外に細菌学的検査項目が併行して行われていることは周知の事実である(1,2)).そして我国における現在の水質検査法(3))では大腸菌群測定法が広く用いられている.すなわち上水試験法(4))および工業用水(JIS)(1))ではLB培地-BGLB培地法(LB-BGLB法と略す),下水試験法ではLB培地法(LB法と略す),食品衛生法および公共用水ではBGLB培地法(BGLB法と略す)を行うとされており,これらはいずれも最確数(MPN)を求める方法である.他方乳製品および工場排水(JIS)(2))ではデスオキシコレート培地(DOC法と略す)を用いての集落数を求める方法も行われている.これら諸種の方法のうち,上水試験法および工業用水(JIS)(1))に適用されている.LB-BGLB法で算定される大腸菌群の検討を試みた.LB-BGLB法で算定される大腸菌群とは"乳糖を分解して酸とガスを産生する好気性または通性嫌気性のグラム陰性無芽胞桿菌である”.と定義され,この条件を満す種属はEscherichia,Klebsiella,Enterobacter,Aeromonas,Erwinia,SerratiaおよびCitrobacter等が包含されている.しかしこれらの種属全てが人畜糞便由来のものではなく,水,植物または土壌に由来する種属も含まれていると言うことである.元来,水質検査における汚染指標菌とは人畜糞便由来の菌を検索することを目的としているのであるから,大腸菌群測定結果をそのまま適用して汚染状況や汚染源の判定を行うと誤りを生ずることになりかねない.我々は過去数年間に亘って児島湾(5)),児島湖(6))を初めとして県下河川(7,8))での汚染調査を行って来たが,その結果のなかで化学検査や現況に照して不当と思われるような高値の大腸菌群数を算定することがしばしばあった.そこで各種調査点での現行の大腸菌群測定で得られる測定結果の検討を,本測定法で算定される大腸菌群の種属分類を行うことにより,糞便汚染の指標性の良否について検討することとした.
en-copyright=
kn-copyright=

en-aut-name=AkatsukaKazuya
en-aut-sei=Akatsuka
en-aut-mei=Kazuya
kn-aut-name=赤塚和也
kn-aut-sei=赤塚
kn-aut-mei=和也
aut-affil-num=1
ORCID=

en-aut-name=MoriYasumi
en-aut-sei=Mori
en-aut-mei=Yasumi
kn-aut-name=森康己
kn-aut-sei=森
kn-aut-mei=康己
aut-affil-num=2
ORCID=

en-aut-name=KoujimaIzumi
en-aut-sei=Koujima
en-aut-mei=Izumi
kn-aut-name=国府島泉
kn-aut-sei=国府島
kn-aut-mei=泉
aut-affil-num=3
ORCID=

en-aut-name=HiraiYoshikazu
en-aut-sei=Hirai
en-aut-mei=Yoshikazu
kn-aut-name=平井義一
kn-aut-sei=平井
kn-aut-mei=義一
aut-affil-num=4
ORCID=

en-aut-name=HamadaHiroshi
en-aut-sei=Hamada
en-aut-mei=Hiroshi
kn-aut-name=浜田博司
kn-aut-sei=浜田
kn-aut-mei=博司
aut-affil-num=5
ORCID=

en-aut-name=AbeMasufumi
en-aut-sei=Abe
en-aut-mei=Masufumi
kn-aut-name=安部益文
kn-aut-sei=安部
kn-aut-mei=益文
aut-affil-num=6
ORCID=

en-aut-name=AbeShigenobu
en-aut-sei=Abe
en-aut-mei=Shigenobu
kn-aut-name=安部重信
kn-aut-sei=安部
kn-aut-mei=重信
aut-affil-num=7
ORCID=

en-aut-name=KukidaShozo
en-aut-sei=Kukida
en-aut-mei=Shozo
kn-aut-name=茎田祥三
kn-aut-sei=茎田
kn-aut-mei=祥三
aut-affil-num=8
ORCID=

en-aut-name=NagataAkihide
en-aut-sei=Nagata
en-aut-mei=Akihide
kn-aut-name=永田哲英
kn-aut-sei=永田
kn-aut-mei=哲英
aut-affil-num=9
ORCID=

en-aut-name=FujiwaraKiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Kiyoshi
kn-aut-name=藤原清
kn-aut-sei=藤原
kn-aut-mei=清
aut-affil-num=10
ORCID=

en-aut-name=HayashiHideo
en-aut-sei=Hayashi
en-aut-mei=Hideo
kn-aut-name=林英生
kn-aut-sei=林
kn-aut-mei=英生
aut-affil-num=11
ORCID=

en-aut-name=KanemasaYasuhiro
en-aut-sei=Kanemasa
en-aut-mei=Yasuhiro
kn-aut-name=金政泰弘
kn-aut-sei=金政
kn-aut-mei=泰弘
aut-affil-num=12
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部ウイルス学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部附属臨床検査技師学校

affil-num=11
en-affil=
kn-affil=岡山大学医学部細菌学教室

affil-num=12
en-affil=
kn-affil=岡山大学医学部細菌学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1297
end-page=1308
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Participation of superoxide generating system, superoxide dismutase and vitamin E in the radiation hazards
kn-title=放射線障害におけるスーパーオキサイド生成系(O(2))とスーパーオキサイド・ディスムターゼ(SOD)及びビタミンEの関与に対する考察
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In relation to the mechanism by which hemolysis was induced in radiated human erythrocytes in vitro, several inducements of membrane lipid peroxidation and protective effects of V.E and SOD were investigated. Results obtained were as follows: (1) K(+)-release from erythrocytes was accelerated by radiation prior to hemolysis. These accelerated hemolysis and K(+)-release were protected remarkably by V.E and evidently by SOD. (2) Mitochondrial Fe(2+) induced and Fe(3+)-O(2) generating system -ADP induced lipid peroxidation, and microsomal O(2) generating system -induced lipid peroxidation were also protected by V.E and SOD. (3) Radiation of X-ray or (60)Co γ-ray accelerated lipid peroxidation of liver homogenate, microsome and liposome. Some of these accelerated lipid peroxidations were protected effectively by V.E and SOD. These results suggest that O(2) and/or OH. generation by radiation induces of membrane lipid peroxidation, which leads deterioration of membrane resulting in the change of ion permeability and then hemolysis.
en-copyright=
kn-copyright=

en-aut-name=AonoKaname
en-aut-sei=Aono
en-aut-mei=Kaname
kn-aut-name=青野要
kn-aut-sei=青野
kn-aut-mei=要
aut-affil-num=1
ORCID=

en-aut-name=YamamotoMichio
en-aut-sei=Yamamoto
en-aut-mei=Michio
kn-aut-name=山本道夫
kn-aut-sei=山本
kn-aut-mei=道夫
aut-affil-num=2
ORCID=

en-aut-name=IidaSosuke
en-aut-sei=Iida
en-aut-mei=Sosuke
kn-aut-name=飯田荘介
kn-aut-sei=飯田
kn-aut-mei=荘介
aut-affil-num=3
ORCID=

en-aut-name=UtsumiKozo
en-aut-sei=Utsumi
en-aut-mei=Kozo
kn-aut-name=内海耕慥
kn-aut-sei=内海
kn-aut-mei=耕慥
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部附属病院中央放射線部

affil-num=2
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部癌源研究所生化学部門
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1289
end-page=1295
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Meningeal leukemia occurring during hematological remission An autopsy
kn-title=寛解期に発症した髄膜白血病の一剖検例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=An autopsy of meningeal leukemia developing during hematological remission was reported. A three-year-old boy with anemia, hepatosplenomegaly and lymphadenopathy was diagnosed as having acute lymphoblastic leukemia based on hematological data. The hematological remission started about a month after the initiation of anticancerous chemotherapy with Prednisone, Vincristine and 6-Mercaptoprine. About two months after the ceasing of administration of Prednisone, symptoms such as headache and vomiting become gradually more severe. The clinical diagnosis was made as aseptic meningitis. The patient expired about two months after the onset. The autopsy revealed intense leukemic infiltration in the entire meninges and a part of the brain, but no infiltration was found in the other organs including the bone marrows, spleen, lymph nodes, liver, testis, etc., at all.
en-copyright=
kn-copyright=

en-aut-name=SonobeHiroshi
en-aut-sei=Sonobe
en-aut-mei=Hiroshi
kn-aut-name=園部宏
kn-aut-sei=園部
kn-aut-mei=宏
aut-affil-num=1
ORCID=

en-aut-name=TakaharaKazuo
en-aut-sei=Takahara
en-aut-mei=Kazuo
kn-aut-name=高原和夫
kn-aut-sei=高原
kn-aut-mei=和夫
aut-affil-num=2
ORCID=

en-aut-name=YodaTadao
en-aut-sei=Yoda
en-aut-mei=Tadao
kn-aut-name=依田忠雄
kn-aut-sei=依田
kn-aut-mei=忠雄
aut-affil-num=3
ORCID=

en-aut-name=YasudaHideki
en-aut-sei=Yasuda
en-aut-mei=Hideki
kn-aut-name=安田英己
kn-aut-sei=安田
kn-aut-mei=英己
aut-affil-num=4
ORCID=

en-aut-name=OgawaKatsuo
en-aut-sei=Ogawa
en-aut-mei=Katsuo
kn-aut-name=小川勝士
kn-aut-sei=小川
kn-aut-mei=勝士
aut-affil-num=5
ORCID=

affil-num=1
en-affil=
kn-affil=岡山赤十字病院臨床検査部病理

affil-num=2
en-affil=
kn-affil=岡山赤十字病院小児科

affil-num=3
en-affil=
kn-affil=岡山赤十字病院小児科

affil-num=4
en-affil=
kn-affil=岡山大学医学部第2病理学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第2病理学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1275
end-page=1288
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on peritoneal dissemination of cancer
kn-title=癌の腹膜播種の成立機序に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The electron microscopic study of the mechanism of the implantation of the tumor cells to the peritoneum has been investigated through the rats. The experiment was made with the inoculation of Walker 256 tumor cells into their abdominal cavity. The morphalogic change and the detouching cell contact of the mesothelium make up the phenomenon, leaving empty spaces to basement membrane. This phenomenon makes it easy that the tumor cell contact with the basement membrane. This contacted tumor cell protrudes the pseudopods and begin subserosal invasion, with moving the intracellular organelles. Stretching the pseudopod, the tumor cell invades the subserosal layer, and the implantation is performed.
en-copyright=
kn-copyright=

en-aut-name=OkabayashiHiroki
en-aut-sei=Okabayashi
en-aut-mei=Hiroki
kn-aut-name=岡林弘毅
kn-aut-sei=岡林
kn-aut-mei=弘毅
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1249
end-page=1274
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on replantation of a developing tooth
kn-title=未完成歯再植に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In the field of oral surgery we apply replantation or transplantation of a tooth as one of the methods to supplement the defect of the tooth. Using puppies experimental studies were conducted on the healing process of a developing tooth after its replantation, especially on the regeneration of blood vessels in the dental pulp and periodontium that had been once depleted of its nutrient, by morphological and three-dimensional observations after the intravenous injection of chloro-percha, as well as by roentgenological and histopathological observations. The results of the observations may briefly be summarized as follows. 1) Roentgenological findings: Up to the 10th day after replantation there could be observed a spreading of pathological abnormality in the periodontal space, but after 20 days the bone regeneration could be observed, after 30 days the lamina dura appeared, and after 90 days the findings seemed to be practically normal. 2) Regenerated blood vessels in the replanted dental pulp: Up to 20 postoperative days the regenerated blood vessels increased with many fusions and windings, but after the completion of new blood flow the number of blood vessels grew less and the blood flow also became orderly, thereafter the vessels became finer with the regeneration of bony hard tissue within the dental pulp making the pulp space more narrow. 3) There could be detected no bony adhesion or absorption as observable at the replantation of a complete tooth. 4) In the fate of replanted tooth the dental pulp and periodontium play an important role. 5) There could be recognized a certain correlation in the roentgenological findings, changes of vascular pictures, and pathohistological findings.
en-copyright=
kn-copyright=

en-aut-name=NagahataShunichiro
en-aut-sei=Nagahata
en-aut-mei=Shunichiro
kn-aut-name=長畠駿一郎
kn-aut-sei=長畠
kn-aut-mei=駿一郎
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部口腔外科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1231
end-page=1248
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental and electron microscopical studies on atrial specific granules
kn-title=心房筋特殊顆粒に関する実験的・電子顕微鏡的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Specific granules in atrial heart muscle cells were examined in normal and treated rats with the histochemical method and electron microscopy. These granules were not stained with routine staining method as azan, but when epon embedded sections were stained with toluidine blue, these granules in sarcoplasm along the nucleus were stained well. With Falck-Hillarp method, atrial muscle cells did not show any fluorescence. By the administration of 5-OHDA and 6-OHDA, false transmitters of catecholamine, the shape and the distribution of granules and the electron density of the core of granules did not change, and any fluorescence was not found with Falck-Hillarp method. The administration of 15% alchohol per os for 20 days increased the number of granules in sarcoplasm along the nucleus slightly and after 60-100 days, these granules increased also in sarcoplasm under the cell membrane or between the myofibrils. These results show that specific granules in atrial heart muscle cells do not contain catecholamine. The function of these granules is also discussed in respect to the result obtained with alchohol administration.
en-copyright=
kn-copyright=

en-aut-name=ChiharaJun
en-aut-sei=Chihara
en-aut-mei=Jun
kn-aut-name=千原純
kn-aut-sei=千原
kn-aut-mei=純
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一解剖学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1215
end-page=1230
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on sideroblasts Part 2. Changes of sideroblasts by cancer chemotherapy
kn-title=Sideroblastに関する臨床的研究 第2編 癌化学療法とSideroblast
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The appearance of sideroblasts was investigated before and after cancer chemotherapies which were carried out 65 times in 53 patients with malignant neoplasms. After treatment, 34 cases showed marked sideroblastosis with a shift to the right in their sideroblastograms ("shifted group"). The other 31 cases showed no sideroblastosis without a shift in their sideroblastograms ("non-shifted group"). The hematological data from these two groups were then studied. After chemotherapy, the shifted group showed significant decreases in erythrocyte counts, hemoglobin concentration, leukocyte counts and nucleated cell counts and a significant increase in erythroid/myeloid ratio, whereas the non-shifted group showed no significant changes. Furthermore, the incidences of serious anemia, leukopenia, decrease in nucleated cell counts and remarkable elevation in serum iron level were significantly higher in the shifted group than in the non-shifted group. These findings suggest that marked sideroblastosis is a useful indicator in the evaluation of impaired hematopoiesis due to cancer chemotherapy.
en-copyright=
kn-copyright=

en-aut-name=SugiyamaMotoharu
en-aut-sei=Sugiyama
en-aut-mei=Motoharu
kn-aut-name=杉山元治
kn-aut-sei=杉山
kn-aut-mei=元治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第二内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1201
end-page=1214
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on sideroblasts Part 1. Changes of sideroblasts in preleukemia
kn-title=Sideroblastに関する臨床的研究 第1編 前白血病状態とSideroblast
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The appearance of sideroblasts was studied in 277 patients with various blood disorders. The appearance rate of sideroblasts was 84.1 ± 11.8% in hypoplastic anemia and 70.7 ± 23.7% in acute myelocytic leukemia, whereas it was 29.5 ± 7.8% in healthy controls. The standard sideroblastogram pattern in patients with hypoplastic anemia was type Ⅱ sideroblast dominance with moderate sideroblastosis. Three out of 87 cases of hypoplastic anemia showed type Ⅲ sideroblast dominance with conspicuous sideroblastosis. Their hematological findings were those of atypical hypoplastic anemia. One of them terminated in acute myelocytic leukemia and could be considered hypoplastic preleukemic stage retrospectively. On the other hand; the sideroblastograms of 6 out of 41 cases of acute myelocytic leukemia showed type Ⅲ sideroblast dominance. Four of them were identical with low percentage leukemia. One of these 4 cases showed ringed sideroblasts on admission and terminated in erythroleukemia at the last stage. These results suggest that in hypoplastic anemia type Ⅲ sideroblast dominance should be considered to be atypical hypoplastic anemia or hypoplastic preleukemic stage, which indicates distrurbed erythroid maturation of preleukemia.
en-copyright=
kn-copyright=

en-aut-name=SugiyamaMotoharu
en-aut-sei=Sugiyama
en-aut-mei=Motoharu
kn-aut-name=杉山元治
kn-aut-sei=杉山
kn-aut-mei=元治
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学第二内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1179
end-page=1200
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Effects of thyroid function on breast cancer in rats and patients with breast diseases
kn-title=乳癌の発生,増殖に及ぼす甲状腺機能の影響に関する実験的ならびに臨床的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=There are controversies over the influences of thyroid function on carciogenesis and progression of the breast cancer. To reveal the interrelation of the breast cancer and thyroid function in rats, this study was performed by employing N-nitrosobutylurea which is known for its carciogenetic action. Female Wistar rats were divided into 4 groups, namely, group with total thyroidectomy, group receiving thyroid sic (without thyroidectomy), group receiving thyroxin (without thyroidectomy), and control group. The thyroidectomy was done 14 weeks after birth and, thyroid sic and thyroxin started to be administered 14 weeks and 8 weeks after birth, respectively. Thyroid sic and thyroxin were given 0.5mg/day/rat and 10μg/100g body weight for 5 days in a week, respectively. N-nitrosobutylurea of 6mg/day/rat was administered to the rats of all the groups for 5 days in a week from the 6th post-natal week. In patients with various breast diseases functional levels of the thyroid gland were determined by measuring triiodothyroxine (T(3)), Thyroxin-binding-globulin (TBG), thyroid-stimulating-hormone (TSH) and prolactin. Blood samples were obtained in early morning and, serum samples obtained were frozen and stored. T(3), TSH and prolactin were measured by radioimmunoassay, triosorb test by resin-sponge uptake method and TBG by electrophoresis with cellulose acetate membrane. The patients studied consisted of 8 with fibroadenoma mammae, 4 with mastopathy and 52 with breast cancer. Results obtained in the study are as follows: 1) Carciogenetic action of N-nitrosobutylurea in rats with total thyroidectomy was greater at the beginning of the administration, but long-term administration of N-nitrosobutyl reduced its carciogenetic effect. 2) There was no carciogenetic influence in NBU on rats with thyroid sic administration. 3) No carciogenetic effect was found in rats with subcutaneous administration of thyroxin. 4) TSH and PRL were higher in patients with breast cancer, particularly in earlier stage, compared with those in patients with benign breast diseases, including mastopathy and fibroadenoma mammae. However, there was no correlation of TSH and PRL levels to stages of the breast cancer. 5) PRL was elevated after radical mastectomy than that before the operation. 6) There was no significant difference in T(3), triosorb test and TBG between patients with the benign diseases and those with breast cancer.
en-copyright=
kn-copyright=

en-aut-name=KajiNobuhiko
en-aut-sei=Kaji
en-aut-mei=Nobuhiko
kn-aut-name=加地信彦
kn-aut-sei=加地
kn-aut-mei=信彦
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第2外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1165
end-page=1178
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental studies on pathogenesis of communicating hydrocephalus following subarachnoid hemorrhage
kn-title=クモ膜下出血に伴う交通性水頭症の発生機序に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Subarachnoid hemorrhage following rupture of aneurysm is one of the significant factors that cause communicating hydrocephalus. The present study describes the mechanisms of communicating hydrocephalus following subarachnoid hemorrhage. Using 26 adult mongrel dogs, cisternal puncture was percutaneously made through which about 10ml of autologous whole blood was injected aseptically. Three to five weeks after the injection, animals were served for the experiments as a chronic subarachnoid hemorrhage group. Subacute subarachnoid hemorrhage group was obtained one week after the injection. Normal animals without cisternal puncture (or subarachnoid hemorrhage) were served as control. Laminectomy at the second cervical level was performed, and two silicone tubes were inserted upward into the cisterna magna (intracranial subarachnoid space) and downward into the spinal subarachnoid space. Then, extradural ligation of the spinal cord was made with silk threads at two different places to completely separate the subarachnoid space into the intracranial and the intrathecal portions. Saline solution was injected through each tube and at the same time changes in the CSF pressure were continuously recorded with transducers. Control cases: In the intracranial space, the elevated pressure (about 2000mmH(2)O) after injection of saline solution rapidly dropped to the level of 100-150mmH(2)O for the period of 2-3 min. In the intrathecal the level of CSF pressure fell down abruptly after the injection, and then decreased more slowly than in the intracranial. Acute subarachnoid hemorrhage cases: The saline solution and blood in an equal volume was injected alternately. The high CSF pressure after the injection of saline solution was sustained for the longer period, as the more volume of blood was injected. At the same number of times of blood injection, the absorption capacity of saline in the intracranial space was more easily impaired than in the intrathecal. Subacute subarachnoid hemorrhage cases: Mildly prolonged elevation of CSF pressure was recorded after the injection of saline solution in both subarachnoid spaces. However the amplitude of pulsation in intracranial subarachnoid space and the grade of initial pressure drop in intrathecal space were almost same as that of control cases. Chronic subarachnoid hemorrhage cases: Prolonged elevation of CSF pressure was seen after the injection of saline in each part. Moreover, in the intracranial space, the amplitude of pulsation of CSF pressure was higher than that in control cases. In the intrathecal, as compared with control cases, the height of initial drop in CSF pressure was more markedly increased. This phenomenon seems to have occurred due to reduced elasticity of meninges against the increased pressure by saline injection. And a distinct increase of amplitude of the pulse wave in the intracranial space of chronic cases seems to be one of the factors that would cause the ventricular dilatation along with the decrease in the elasticity of the meninges. Actually, ventricular dilatation was recognized in almost all chronic animals.
It may conclude that, following subarachnoid hemorrhage, the impairment of CSF absorption in not only intracranial but also intrathecal subarachnoid spaces, the decrease of the spinal dural sac elasticity and the increased amplitude of CSF pulsation seem to play an important role in producing communicating hydrocephalus.
en-copyright=
kn-copyright=

en-aut-name=SuzukiKenji
en-aut-sei=Suzuki
en-aut-mei=Kenji
kn-aut-name=鈴木健二
kn-aut-sei=鈴木
kn-aut-mei=健二
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学脳神経外科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1157
end-page=1163
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Diagnosis of heart disease using by RI angio cardiography Part Ⅲ. Cases of left to right shunts
kn-title=RI Angiocardiographyによる心疾患の診断 第3編 左-右シャント症例について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Count ratio (C(2)/C(1)) technique for detection of left to right shunts by radionuclide was performed. Count ratio technique of ASD cases accurately detected shunts and could reliably separate from normals, but there were a few false positive in patients with ventricle septal defect. There was no correlation between C(2)/C(1) ratio and oximetry. Postoperatively, C(2)/C(1) ratios of ASD cases were resumed to normal or close to normal but some cases of VSD were not returned to normal.
en-copyright=
kn-copyright=

en-aut-name=TanabeMasatada
en-aut-sei=Tanabe
en-aut-mei=Masatada
kn-aut-name=田辺正忠
kn-aut-sei=田辺
kn-aut-mei=正忠
aut-affil-num=1
ORCID=

en-aut-name=TamaiToyosato
en-aut-sei=Tamai
en-aut-mei=Toyosato
kn-aut-name=玉井豊理
kn-aut-sei=玉井
kn-aut-mei=豊理
aut-affil-num=2
ORCID=

en-aut-name=KawaseEtsuo
en-aut-sei=Kawase
en-aut-mei=Etsuo
kn-aut-name=川瀬悦郎
kn-aut-sei=川瀬
kn-aut-mei=悦郎
aut-affil-num=3
ORCID=

en-aut-name=TakakiHisao
en-aut-sei=Takaki
en-aut-mei=Hisao
kn-aut-name=高木寿生
kn-aut-sei=高木
kn-aut-mei=寿生
aut-affil-num=4
ORCID=

en-aut-name=MizukawaKiichiro
en-aut-sei=Mizukawa
en-aut-mei=Kiichiro
kn-aut-name=水川帰一郎
kn-aut-sei=水川
kn-aut-mei=帰一郎
aut-affil-num=5
ORCID=

en-aut-name=MorimotoSetsuo
en-aut-sei=Morimoto
en-aut-mei=Setsuo
kn-aut-name=森本節夫
kn-aut-sei=森本
kn-aut-mei=節夫
aut-affil-num=6
ORCID=

en-aut-name=HashimotoKeiji
en-aut-sei=Hashimoto
en-aut-mei=Keiji
kn-aut-name=橋本啓二
kn-aut-sei=橋本
kn-aut-mei=啓二
aut-affil-num=7
ORCID=

en-aut-name=SatoKatashi
en-aut-sei=Sato
en-aut-mei=Katashi
kn-aut-name=佐藤功
kn-aut-sei=佐藤
kn-aut-mei=功
aut-affil-num=8
ORCID=

en-aut-name=HirakiYoshio
en-aut-sei=Hiraki
en-aut-mei=Yoshio
kn-aut-name=平木祥夫
kn-aut-sei=平木
kn-aut-mei=祥夫
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大孝医学部放射線医学教室

affil-num=2
en-affil=
kn-affil=岡山大孝医学部放射線医学教室

affil-num=3
en-affil=
kn-affil=岡山大孝医学部放射線医学教室

affil-num=4
en-affil=
kn-affil=岡山大孝医学部放射線医学教室

affil-num=5
en-affil=
kn-affil=岡山大孝医学部放射線医学教室

affil-num=6
en-affil=
kn-affil=岡山大孝医学部放射線医学教室

affil-num=7
en-affil=
kn-affil=岡山大孝医学部放射線医学教室

affil-num=8
en-affil=
kn-affil=岡山大孝医学部放射線医学教室

affil-num=9
en-affil=
kn-affil=岡山大孝医学部放射線医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1151
end-page=1155
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Prevention of immunosuppression after surgery by levamisole
kn-title=Levamisole投与による癌患者術後免疫能低下の防止
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Fluctuation of the postoperative lymphocyte blastformation rates against phytohemagglutinin (abbreviated as the blastoformation rate) were examined in gastrointestinal cancer patients administered with levamisole 150 mg/day, three consecutive days, every other week from the third day before operation comparing with the values of the control cases. In the cases of curative resection the postoperative blastformation rate of the control group decreased due to operation damage from the first to the third postoperative week and recovered at the fourth week. But, the postoperative blastformation rates of the levamisole group did not decrease, moreover, increased continuously to the fourth week. This result would induce the development of survival ratio in the gastrointestinal cancer patients with administered levamisole.
en-copyright=
kn-copyright=

en-aut-name=MiwaHiroaki
en-aut-sei=Miwa
en-aut-mei=Hiroaki
kn-aut-name=三輪恕昭
kn-aut-sei=三輪
kn-aut-mei=恕昭
aut-affil-num=1
ORCID=

en-aut-name=KawaiTomonori
en-aut-sei=Kawai
en-aut-mei=Tomonori
kn-aut-name=河合知則
kn-aut-sei=河合
kn-aut-mei=知則
aut-affil-num=2
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1145
end-page=1149
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Diagnosis of heart disease using by RI angiocardiography Part Ⅱ. Mitral valve disease
kn-title=RI angio-cordiographyによる心疾患の診断 第2編 僧帽弁疾患症例を中心として
en-subtitle=
kn-subtitle=
en-abstract=This report represents an extension of our use of a Scintillation (Anger) camera with computer processing (Toshiba DAP 5000-2) of data for evaluation of mitral valve disease (11 cases). For these studies we have administered 10 mCi of (99m)Tc intravenously and have followed its passage through the heart and lung using techniques for data acquisition: a 35 mm camera, a video tape system for data storage and replay for computer analysis using a DAP 5000-2. RI dilution curves recorded on the right ventricle, the left lung and the left ventricle were analyzed to obtain following parameters, namely interventricular peak to peak time, C(2)/C(1) ratio of each dilution curves. These data showed following: 1) Interventricular peak to peak time normal group (12 cases): 6.40 ± 1.18 seconds mitral valve disease (11 cases): 11.34 ± 3.69 seconds 2) a) C(2)/C(1) ratio of the right ventricle normal group: 0.45 ± 0.08 seconds mitral valve disease: 0.58 ± 0.17 seconds b) C(2)/C(1) ratio of the left ventricle normal group: 0.38 ± 0.09 seconds mitral valve disease: 0.49 ± 0.11 seconds c) C(2)/C(1) ratio of the left lung normal group: 0.45 ± 0.08 seconds mitral valve disease: 0.50 ± 0.12 seconds
kn-abstract=心疾患を有する患者では,その循環動態は種々の因子により容易に変化するものであり,一回の検査のみで決して正確にその患者の動態を表わしているとはいいがたい.この点コンピューターを用いたRI angio-cardiography(以下RCGと略す)は被曝線量も少く,生理的状態を損うことなく繰返し検査を行うことが出来る非観血的方法であり,心疾患者の術前術後の変化,治療経過観察に極めて有用である.従って,僧帽弁疾患におけるRCGによる右室,左室peak to peak time C(2)/C(1)比の解折は,上述の点後於て重要な臨床情報を提供すると考えられる.今回は僧帽弁疾患を中心としてこれらの点について若干の検討を試みた.
en-copyright=
kn-copyright=

en-aut-name=TanabeMasatada
en-aut-sei=Tanabe
en-aut-mei=Masatada
kn-aut-name=田辺正忠
kn-aut-sei=田辺
kn-aut-mei=正忠
aut-affil-num=1
ORCID=

en-aut-name=TamaiToyosato
en-aut-sei=Tamai
en-aut-mei=Toyosato
kn-aut-name=玉井豊理
kn-aut-sei=玉井
kn-aut-mei=豊理
aut-affil-num=2
ORCID=

en-aut-name=KawaseEtsuo
en-aut-sei=Kawase
en-aut-mei=Etsuo
kn-aut-name=川瀬悦郎
kn-aut-sei=川瀬
kn-aut-mei=悦郎
aut-affil-num=3
ORCID=

en-aut-name=TakakiHisao
en-aut-sei=Takaki
en-aut-mei=Hisao
kn-aut-name=高木寿生
kn-aut-sei=高木
kn-aut-mei=寿生
aut-affil-num=4
ORCID=

en-aut-name=MizukawaKiichiro
en-aut-sei=Mizukawa
en-aut-mei=Kiichiro
kn-aut-name=水川帰一郎
kn-aut-sei=水川
kn-aut-mei=帰一郎
aut-affil-num=5
ORCID=

en-aut-name=MorimotoSetsuo
en-aut-sei=Morimoto
en-aut-mei=Setsuo
kn-aut-name=森本節夫
kn-aut-sei=森本
kn-aut-mei=節夫
aut-affil-num=6
ORCID=

en-aut-name=HashimotoKeiji
en-aut-sei=Hashimoto
en-aut-mei=Keiji
kn-aut-name=橋本啓二
kn-aut-sei=橋本
kn-aut-mei=啓二
aut-affil-num=7
ORCID=

en-aut-name=SatoKatashi
en-aut-sei=Sato
en-aut-mei=Katashi
kn-aut-name=佐藤功
kn-aut-sei=佐藤
kn-aut-mei=功
aut-affil-num=8
ORCID=

en-aut-name=AonoKaname
en-aut-sei=Aono
en-aut-mei=Kaname
kn-aut-name=青野要
kn-aut-sei=青野
kn-aut-mei=要
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部放射線医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1139
end-page=1144
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental studies on corrected orthogonal lead systems of vectorcardiography with canine homogenous torso model
kn-title=犬のベクトル心電図の誘導法について 胴体模型による基礎的検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The lead vectors determined with Frank's system and McFee-Parungao system for dogs using canine torso model were studied. The dog which was used for making a torso model has a body weight of 16.2kg. The dimensions of torso model were left to right of 14.0 cm, front to back 19.5 cm and height of 44.0 cm. The center of ventricular depolarization in the canine heart was determined by the chest X-Ray film. Its position was 0.75 cm to the left, 2.9 cm to the front from the body center in the fifth intercostal space. The artificial heart dipole was placed on the ventricular depolarization center of the torso model filled with 0.1% NaCl solution. Electrode position on the torso surface were designated by two quantities: the level (number I through X) and the angle in the transverse plane are each equal to 100. The level are separated by 3 cm. The dipole was placed at Ⅵ level. Image Surface was oval and located on left anteriorly and slightly inferiorly from the heart center. Normality and orthogonality of lead vectors were examined on the torso with Frank's system and McFee-Parungao system for dogs resulting the latter to be better than the former. The effect of electrode position of transverse level was tested. An anterioly shift of these electrods resulted in a increase in X and Z components of Lead X, whereas a posterioly shift tended to decrease this dimensions.
en-copyright=
kn-copyright=

en-aut-name=HaraokaShoichi
en-aut-sei=Haraoka
en-aut-mei=Shoichi
kn-aut-name=原岡昭一
kn-aut-sei=原岡
kn-aut-mei=昭一
aut-affil-num=1
ORCID=

en-aut-name=FujitaTakashi
en-aut-sei=Fujita
en-aut-mei=Takashi
kn-aut-name=藤田興
kn-aut-sei=藤田
kn-aut-mei=興
aut-affil-num=2
ORCID=

en-aut-name=SaitoDaiji
en-aut-sei=Saito
en-aut-mei=Daiji
kn-aut-name=斉藤大治
kn-aut-sei=斉藤
kn-aut-mei=大治
aut-affil-num=3
ORCID=

en-aut-name=YoshidaHidenori
en-aut-sei=Yoshida
en-aut-mei=Hidenori
kn-aut-name=吉田英紀
kn-aut-sei=吉田
kn-aut-mei=英紀
aut-affil-num=4
ORCID=

en-aut-name=OginoYasuhiro
en-aut-sei=Ogino
en-aut-mei=Yasuhiro
kn-aut-name=荻野泰洋
kn-aut-sei=荻野
kn-aut-mei=泰洋
aut-affil-num=5
ORCID=

en-aut-name=KusuharaShunichi
en-aut-sei=Kusuhara
en-aut-mei=Shunichi
kn-aut-name=楠原俊一
kn-aut-sei=楠原
kn-aut-mei=俊一
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1129
end-page=1138
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on pathophysiology and treatment in patients with active acromegaly Part Ⅱ. Studies on pharmacological treatment for active acromegalic patients
kn-title=末端肥大症の病態並びに治療に関する研究 第二編 内科的治療に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Four patients with active acromegaly were treated for 18 to 180 days with 2-Br-α-ergocryptine(CB-154), and the following results were obtained. 1). Two patients showed an improvement in glucose tolerance with short term treatment with CB-154, and other patients showed a change in their voice and a reduction in soft tissue thicking with long term treatment. 2). The effect of CB-154 on LH-RH induced hGH release was studied in 2 patients with active acromegaly. In a patient whose hGH levels were suppressed by administration of CB-154 (CB-154 responder), CB-154 completely blocked LH-RH induced hGH release, whereas in a CB-154 non-responder CB-154 did not block LH-RH induced hGH release. 3). Under CB-154 administration plasma hGH concentration fell remarkably during awake, but plasma hGH level during sleep was not suppressed in patients with active acromegaly. These results suggest that CB-154 is a potent drug for the treatment of acromegaly and act on both superior centers, the hypothalamus and the pituitary gland.
en-copyright=
kn-copyright=

en-aut-name=HanafusaManabu
en-aut-sei=Hanafusa
en-aut-mei=Manabu
kn-aut-name=花房学
kn-aut-sei=花房
kn-aut-mei=学
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第三内科
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1117
end-page=1128
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on pathophysiology and treatment in patients with active acromegaly Part I. Studies on pathophysiology of active acromegaly
kn-title=末端肥大症の病態並びに治療に関する研究 第一編 各種薬物負荷に対する血漿成長ホルモンの反応性に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The effects of several drugs on the release of human growth hormone (hGH) were investigated, and the following results were obtained. 1). Single intravenous injection of insulin or drop infusion of L-arginine provocated an increase in plasma hGH in 3 out of 8 and 4 out of 6 patients with active acromegaly, respectively. 2). Single intravenous injection of thyrotropin-releasing hormone (TRH) or luteinizing hormone-releasing hormone (LH-RH) provoked a prompt increase in plasma hGH in 7 out of 13 and 4 out of 10 patients with acromegaly, respectively, whereas no significant change in plasma hGH was observed in normal subjects. 3). Plasma hGH levels decreased significantly within 30 min after an injection of glucagon in 7 out of 10 patients with acromegaly. 4). Single oral administration of L-dopa or 2-Br-α-ergocryptine (CB-154) induced a significant fall in hGH levels in patients with acromegaly, but a significant rise in plasma hGH in normal subjects. 5). The hGH response to L-dopa was compared before and after incomplete removal of pituitary adenoma in 2 patients with active acromegaly. Before surgery L-dopa decreased the plasma hGH levels, while after surgery L-dopa caused a significant increase in plasma hGH levels in both patients. At 10 months after surgery L-dopa decreased the plasma hGH levels again in one patient despite a low basal hGH concentration. These results suggest that the primary disorder of the acromegaly resides in the pituitary level at least in some patients with acromegaly.
en-copyright=
kn-copyright=

en-aut-name=HanafusaManabu
en-aut-sei=Hanafusa
en-aut-mei=Manabu
kn-aut-name=花房学
kn-aut-sei=花房
kn-aut-mei=学
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第三内科
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1111
end-page=1116
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Influence of bucolome on non-bilirubin fraction showing positive diazo-reaction in the bile
kn-title=胆汁中非bilirubin diazo反応陽性分画に及ぼすbucolomeの影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Influence of bucolome on non-bilirubin fraction showing positive diazo-reaction (non-bilirubin fraction, dipyrril substances) was studied using heterozygous Gunn rats. Two hundred mg of bucolome per kg of rat body weight was injected intramuscularly once a day for four days. The bile collection by the bile duct canulation was started 24 hours after the final drug loading and continued for 22 hours. The following results were obtained: 1) Amount of non-bilirubin in the rat bile increased significantly in bucolome loading group than in the control group. 2) Radioactivity in non-bilirubin fraction in the bile after bucolome and (3)H-bilirubin loading was not increased significantly than in the control. 3) In bucolome loading group, bile volume increased significantly but the excreted amount of bilirubin did not increased. According to these results, bucolome did not catabolize bilirubin directly but increased non-bilirubin fraction, dipyrril substances, in the bile.
en-copyright=
kn-copyright=

en-aut-name=KondoTadasuke
en-aut-sei=Kondo
en-aut-mei=Tadasuke
kn-aut-name=近藤忠亮
kn-aut-sei=近藤
kn-aut-mei=忠亮
aut-affil-num=1
ORCID=

en-aut-name=YoneiJiro
en-aut-sei=Yonei
en-aut-mei=Jiro
kn-aut-name=米井二郎
kn-aut-sei=米井
kn-aut-mei=二郎
aut-affil-num=2
ORCID=

en-aut-name=IshikawaYasusuke
en-aut-sei=Ishikawa
en-aut-mei=Yasusuke
kn-aut-name=石川泰祐
kn-aut-sei=石川
kn-aut-mei=泰祐
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1105
end-page=1109
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Two cases of Aleviatin (Diphenylhydantoin) intoxication
kn-title=抗てんかん剤（アレビアチン）による平衡障害の2症例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Aleviatin (Diphenylhydantoin) is well known as an excellent antiepileptic drug, especially against grand-mal convulsion. Side reaction of this drug, however, was various and the reports concerning side reaction were many. The authors have reported two patients of Aleviatin intoxication with the complaint of postural disturbance. Some discussions and comments were made on the cases and literatures. Summarizing the symptoms of these side reactions, 1. acute intoxication a. skin manifestations: rash like scarlet fever or urticaria, exfoliative dermatitis, systemic lupus erythematoid eruption, Stevens-Johnson syndrome b. neurological signs: postural disturbance, ataxia, tremor, dysarthria, diplopia, nystagmus, tinnitus, hearing impairment, choreoathetoid movement c. psychological signs: nervousness, excitement, disorientation, insomnia, pseudodementia d. blood manifestation: leucopenia, anemia, leukemoid change e. digestive disorders: thirst, nausea, vomiting, constipation 2. chronic intoxication a. gum hypertrophy b. hypertrichosis c. hyperglycemia
en-copyright=
kn-copyright=

en-aut-name=ShibataShiro
en-aut-sei=Shibata
en-aut-mei=Shiro
kn-aut-name=柴田四郎
kn-aut-sei=柴田
kn-aut-mei=四郎
aut-affil-num=1
ORCID=

en-aut-name=TakedaTsuneo
en-aut-sei=Takeda
en-aut-mei=Tsuneo
kn-aut-name=武田恒雄
kn-aut-sei=武田
kn-aut-mei=恒雄
aut-affil-num=2
ORCID=

en-aut-name=KajiharaMasayuki
en-aut-sei=Kajihara
en-aut-mei=Masayuki
kn-aut-name=梶原正行
kn-aut-sei=梶原
kn-aut-mei=正行
aut-affil-num=3
ORCID=

en-aut-name=SaitoRyusuke
en-aut-sei=Saito
en-aut-mei=Ryusuke
kn-aut-name=斉藤龍介
kn-aut-sei=斉藤
kn-aut-mei=龍介
aut-affil-num=4
ORCID=

en-aut-name=EndoYoichi
en-aut-sei=Endo
en-aut-mei=Yoichi
kn-aut-name=遠藤洋一
kn-aut-sei=遠藤
kn-aut-mei=洋一
aut-affil-num=5
ORCID=

en-aut-name=OguraYoshio
en-aut-sei=Ogura
en-aut-mei=Yoshio
kn-aut-name=小倉義郎
kn-aut-sei=小倉
kn-aut-mei=義郎
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科

affil-num=2
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科

affil-num=3
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科

affil-num=4
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科

affil-num=5
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科

affil-num=6
en-affil=
kn-affil=岡山大学医学部耳鼻咽喉科
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1093
end-page=1104
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental model of hyperargininemia, Amino acids and guanidino compounds in serum, urine and brain of hyperargininemic rabbit
kn-title=実験的高アルギニン血症ウサギに関する研究 第1編 アルギニン大量負荷ウサギの血清,尿および脳組織中のアミノ酸並びにグアニジノ化合物について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A hyperargininemia was induced by oraly administration of arginine in rabbit, and amino acids and guanidino compounds were analysed in the serum, urine and brain. As the experimental results, the following changes in the content of amino acids and guanidino compounds were observed: 1) Urea and ornithine increased, and otherwise, threonine, serine, isoleucine and lysine decreased significantly in the serum of the experimental hyperargininemic rabbit. 2) Among the serum guanidino compounds, only guanidinosuccinic acid increased significantly in the hyperargininemics. 3) Urinaly urea, alanine, cystathionine, ornithine and lysine increased significantly in the hyperargininemics. 4) Taurocyamine, guanidinosuccinic acid, glycocyamine, N-acetylarginie and γ-guanidinobutyric acid increased significantly in the urine of the hyperargininemics, and otherwise several unknown guanidino compounds were observed as higher peaks in the analysing record of the hyperargininemics. 5) Urea and ornithine increased and lysine and l-methylhistidine decreased significantly in the brain of the hyperargininemics. 6) Glycocyamine and N-acethylarginine increased significantly in the brain of the hyperargininemics, but no significant change was observed in other guanidino compounds in the brain of our experimental animal.
en-copyright=
kn-copyright=

en-aut-name=SuwakiSadayoshi
en-aut-sei=Suwaki
en-aut-mei=Sadayoshi
kn-aut-name=洲脇貞吉
kn-aut-sei=洲脇
kn-aut-mei=貞吉
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳代謝研究施設機能生化学部門
END

start-ver=1.4
cd-journal=joma
no-vol=90
cd-vols=
no-issue=9-10
article-no=
start-page=1073
end-page=1091
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1978
dt-pub=19781030
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Electron microscopic study on the surfaces of Gross virus-induced murine leukemia cells and budding virions
kn-title=マウス白血病細胞における細胞表面構造と出芽ウイルスの電子顕微鏡的研究 ―特にフリーズエッチング法を主とした観察―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A study was made on alterations in the surface structures of Gross virus-induced murine thymic leukemia cells and budding virions with freeze-etching technique. The budding virions were clearly observed on the fractured faces of cell surface as well as microvilli and ruffled membranes. Knobs, approximately 10 nm in diameter, were demonstrated on the surfaces of budding virions. Extracellular virions had also the similar structure on their surfaces. On the fractured protoplasmic face (P.F.), 8.5-10 nm typical intramembranous particles (I.P.) were arranged randomly without detectable aggregated particles. There also appeared smooth semispherical protrusions which could be regarded as budding virions. Comparison was carried out between numbers of I.P. in leukemia cells and those in normal thymocytes, showing that I.P. slightly increased in leukemia cells.
en-copyright=
kn-copyright=

en-aut-name=FujioKouji
en-aut-sei=Fujio
en-aut-mei=Kouji
kn-aut-name=藤尾幸司
kn-aut-sei=藤尾
kn-aut-mei=幸司
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部ウイルス学教室
END