start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=1143 end-page=1153 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Nehb Lead System Part Ⅱ a clinical significance of the Nehb Lead System kn-title=Nehb誘導に関する研究 第二編 Nehb誘導の臨床的意義 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A characteristic of the Nehb lead system and especially a value of the lead Nehb-D were studied in 136 subjects 1) The lead Nehb-D was similar to the lead V(7), the lead Nehb-A to the lead V(5) and the lead Nehb-J to the lead V(3). Those similarities were about 50 per cent each. 2) On a form of QRS complex of the Nehb lead system, the lead D was mostly qR type. The lead A was mostly qRs, then RS and qRs type in order of frequency. The lead J was mostly RS type. 3) The electrocardiograms of 80 healthy men were all normal both in the standard lead system and in the Nehb lead system. 4) The number of cases of abnormal ST changes at rest were 22 in the standard lead system and 55 in the lead Nehb-D out of 136 cases. 5) The number of abnormal ST-T changes after exercise tests were 61 in the standard lead system and 90 in the Nehb lead system. 6) In the cases with abnormal ST-T changes only in the leads Ⅱ, Ⅲ and aVf, the abnormal ST-T changes of the lead Nehb-D were a few. en-copyright= kn-copyright= en-aut-name=YonaharaNobuhiko en-aut-sei=Yonahara en-aut-mei=Nobuhiko kn-aut-name=与那原宣彦 kn-aut-sei=与那原 kn-aut-mei=宣彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=1133 end-page=1142 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Nehb Lead System Part Ⅰ Fundamental studies on the Nehb Lead System kn-title=Nehb誘導に関する研究 第一編 Nehb誘導の基礎的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The Nehb lead system was examined to emphasize and find out at early stage ST depression of the left precordial leads (V(5), V(6), V(7)). The results were as follows. 1) The 19 patiens with ischemic heart disease were recorded after exercise tests. The mean QRS vector was situated on the left, posterior and inferior. The mean ST vector was directed to the right, anterior and superior. Namely, the former tended to be at a 180° angle to the latter. 2) The experiments of a torso, which was made by atrunk model of a japanese adult man, proved that a magnitude of the lead Nehb-D was larger than those of the leads V(5), V(6), V(7). From the image surface which was obtained from the experiments of the torso the direction of the lead Nehb-D was situated on the same left, posterior and inferior as the leads V(6), V(7), especially close at the lead V(7). The lead Nehb-A was the most largest magnitude, but the direction was situated on the same left, anterior and inferior as the V(5). The directions of the leads Nehb-D, A, J and the leads V(5), V(6), V(7) were the same in both azimuth and elevation and the image surface. Accordingly, the lead Nehb-D is usefull to emphasize and find out ST depression earlier than in the left precordial leads (V(5), V(6), V(7)). en-copyright= kn-copyright= en-aut-name=YonaharaNobuhiko en-aut-sei=Yonahara en-aut-mei=Nobuhiko kn-aut-name=与那原宣彦 kn-aut-sei=与那原 kn-aut-mei=宣彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=1119 end-page=1132 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies on Assisted Circulation in Acute Hypoxic State kn-title=急性Hypoxiaにおける補助循環に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Respiratory insufficiency arises from various causes. Treatment by mechanical ventilators is not always effective for it. When it arises, long term artificial pulmonary substitution is thought to be a reasonable approach to provide better results. However the best method for improving survival rate has not estadlished vet. Author studied hemodynamics in acute hypoxic state upon dogs weighing 9kg to 12kg. Secondary the hemodynamic effects and gas change capabilities of three methods of extracorporeal respiratory support which were venovenous, venoarterial and arteriovenous perfusion was studied in this state. In acute hypoxic state (PaO(2); 20-25mmHg), both left and right heart pressure rose and cardiac output increased at first which was called hypercirculatory state. Secondary, left heart pressure went down and cardiac output was decreased. However right heart pressure stayed high. Then the right heart peessure becawe low and the dogs died finally in average 63 minutes. Hypercirculatory state was early seen on venovenous and arteriovenous perfusion, and PaO(2) did not rise satisfactorily. On the other hand, hypercirculatory state was not seen on venoarterial perfusion, and PaO(2) rose satisfactory. Author concluded venoarterial perfusion was the best method for respiratory insufficiency cases which was not improved by mechanical ventilation. en-copyright= kn-copyright= en-aut-name=YamaneMasataka en-aut-sei=Yamane en-aut-mei=Masataka kn-aut-name=山根正隆 kn-aut-sei=山根 kn-aut-mei=正隆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2外科教室 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=1093 end-page=1117 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Exfoliative cytologic studies of cysts in the jaw and oral region kn-title=顎口腔領域嚢胞の剥離細胞学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Exfoliative cytologic studies were carried out with 102 cases which had been enucleated, marsupialized or biopsied at the Department of Oral Surgery, Okayama University Medical School, and 15 cases of ameloblastoma were also studied as the disease which required differencial diagnosis. 1) The number of exfoliated cells showed a considerable difference between the cases. 2) The exfoliated cells from the cysts were appeared mostly as the individual cells and the aggregation of few cells, while the ceses of ameloblastoma showed a great number of cell aggregation in addition to them. 3) The cytoplasm: The stainability, the median palatine cyst, dermoid cysts and globulomaxillary cyst were well, postoperative buccal cysts, follicular dental cysts, radicular cysts and ameloblastomas were stained to an intermediate degree, while only the salivary retention cysts were stained poorly. As to the stainability according to colors most of the dermoid cyst cells were stained to yellow, but cells from other cases were stained in a blue color. Moreover dermoid cysts showed the superficial cells mostly, whereas in the other cases most of cells were from the intermediate layer. As for the contour shape, each cyst case presented a specific shape, polygonal, columnar and oval, which indicated the possibility of determination of the origin of epithelial cells to a certain degree. 4) Nucleus: While there could not be seen so much considerable differences in the nucleus as with the cytoplasm, there were some cases showing abnormalities such as irregularities in chromatin pattern, chromatin content, thickenning of the nuclear membrane, nuclear outline, multinucleation and anisokaryosis. 5) Nucleole: Some nucleoles showed abnormality in the number, stainability and contour but the degree of such abnormalities were less than cells from the malignant tumors. 6) The long diameters, short diameters and the area of cytoplasm showed significant differences in the cysts and ameloblastomas compared with normal buccal mucosa, while the same studies of the nuclei showed the significant differences could be founded some but not all of them. The C/N ratio were increased. en-copyright= kn-copyright= en-aut-name=SakuraiYoh en-aut-sei=Sakurai en-aut-mei=Yoh kn-aut-name=桜井洋 kn-aut-sei=桜井 kn-aut-mei=洋 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部口腔外科学教室 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=1085 end-page=1092 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on bilirubin in bile. Part 1. Excretion of salt-form bilirubin into bile kn-title=胆汁bilirubinに関する研究 第1編 塩型bilirubinの胆汁への排泄 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Salt-form bilirubin, one of the direct bilirubin, was prepared from human bile. The saltform bilirubin dissolved with physiological saline was injected into tail vein of Wister strain rat, heterozygote and homozygote Gunn rat; the bile was collected up to eight hours after loading of the salt-form bilirubin. The amount of salt-form bilirubin excreted into bile and its characterization of excreted salt-form bilirubin was studied by thin layer chromatography and photochemically. The following results were obtained; 1) Absorption maximum of the salt-form bilirubin excreted into bile was observed at 400-430 nm, and absorption maximum of its azo-pigment in pH 14 was at 555-560 nm. The salt-form bilirubin showed negative ninhydrin reaction and benzidine reaction, and the nature of excreted salt-form bilirubin was coincidated with the former reports from our department. According to qualitative reactions and the absorption maxima, the salt-form bilirubin excreted into bile did not change its nature and conjugation. 2) Up to eight hours collection of bile after loading of the salt-form bilirubin amounted under 200 mcg, it was excreted 64.42% in Wister strain rat and 53.81% in heterozygote and homozygote Gunn rat in the average, respectively. The maximum excretion of the salt-form bilirubin was observed in the first two hours after loading in each groups; these portion occupied at 42.9% and 46.5% of the excreted amount in eight hours, respectively. There was no significant differences between the excretion rate of the salt-form bilirubin in Wister strain rat and heterozygote and homozygote Gunn rat. en-copyright= kn-copyright= en-aut-name=MiyoshiKanji en-aut-sei=Miyoshi en-aut-mei=Kanji kn-aut-name=三好莞爾 kn-aut-sei=三好 kn-aut-mei=莞爾 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=1075 end-page=1083 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Hemodynamic Effects of Three Kinds of Beta-Adrenergic Blockade (Alprenolol, Propranolol and Practolol) -experimental study- kn-title=Beta-Adrenergic Blockadeの血行動態に与える影響―Alprenolol, PropranololおよびPractololの実験的比較検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Effects of alprenolol, propranolol and practolol on hemodynamics were studied in open-chest anesthetized dogs, and following results were obtained; Coronary blood flow was decreased accompanied with a rise in coronary vascular resistance following the administiation of the drug. Cardiac output and heart rate were decreased, and total peripheral resistance was elevated significantly. Practolol produced lesser changes in coronary and systemic hemodynamics than alprenolol or propranolol; especially lesser elevation in total peripheral resistance and smaller decrease in maximun blood flow of aorta. en-copyright= kn-copyright= en-aut-name=SaitoDaiji en-aut-sei=Saito en-aut-mei=Daiji kn-aut-name=斉藤大治 kn-aut-sei=斉藤 kn-aut-mei=大治 aut-affil-num=1 ORCID= en-aut-name=TawaraRitsuya en-aut-sei=Tawara en-aut-mei=Ritsuya kn-aut-name=田原律哉 kn-aut-sei=田原 kn-aut-mei=律哉 aut-affil-num=2 ORCID= en-aut-name=HiranoKazuhiro en-aut-sei=Hirano en-aut-mei=Kazuhiro kn-aut-name=平野和博 kn-aut-sei=平野 kn-aut-mei=和博 aut-affil-num=3 ORCID= en-aut-name=UedaMinoru en-aut-sei=Ueda en-aut-mei=Minoru kn-aut-name=上田稔 kn-aut-sei=上田 kn-aut-mei=稔 aut-affil-num=4 ORCID= en-aut-name=MaeRitsuo en-aut-sei=Mae en-aut-mei=Ritsuo kn-aut-name=前律夫 kn-aut-sei=前 kn-aut-mei=律夫 aut-affil-num=5 ORCID= en-aut-name=MinatoTakeshi en-aut-sei=Minato en-aut-mei=Takeshi kn-aut-name=湊武 kn-aut-sei=湊 kn-aut-mei=武 aut-affil-num=6 ORCID= en-aut-name=YonaharaNobuhiko en-aut-sei=Yonahara en-aut-mei=Nobuhiko kn-aut-name=与那原宣彦 kn-aut-sei=与那原 kn-aut-mei=宣彦 aut-affil-num=7 ORCID= en-aut-name=HaraokaShoichi en-aut-sei=Haraoka en-aut-mei=Shoichi kn-aut-name=原岡昭一 kn-aut-sei=原岡 kn-aut-mei=昭一 aut-affil-num=8 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一内科教室 affil-num=8 en-affil= kn-affil=岡山大学医学部中央検査部 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=1059 end-page=1074 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies of Electrolyte Metabolism During Extracorporeal Circulation kn-title=体外循環時における電解質代謝の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has been shown that changes of serum electrolyte have occurred during cardiopumonary bypass and that the changes have affected on prognosis of open heart surgery. This study was undertaken to reveal causes of the electrolyte changes and to minimize them. Clinical study was performed in 48 patients who underwent open heart surgery for either congenital or aquired heart disease. Experimental study was made using 30 healthy mongrel dogs and a main purpose of the experiment was to determine mutual changes of the electrolyte, including sodium, potassium and magnesium. when magnesium was added in the priming solution Heart-lung machine employed was disc oxygenator type (Pemco) or bubble oxygenator type (Junken), primed with hemodiluted solution (20%) under normothermia. The following results were obtained: -Clinical studies- 1) Serum potassium and magnesium levels decreased during perfusion, but potassium level of R. B. C. increased a little. Urinary excretion of potassium increased after perfusion. However, it started during perfusion in a group (group B) in whom digitalis, KCl and diuretic had been given before operation. Potassium of the serum and R. B. C. returned to the preperfusion level by the 1st post-op. day and magnesium level did by the 4th post-op. day, but in group B it returned after the 4th post-op. iday. 2) Hypokalemia during perfusion became severer as perfusion time was prolonged. 3) Open heart surgery resulted in metabolic acidosis but serum potassium level was not in correlation with serum PH. 4) Potassium and magnesium levels in the muscle decreased after perfusion, while sodium level increased. -Experimental studies- 1) Potassium and magnesium levels of the serum and R. B. C. decreased as well as in the clinical studies. 2) In the cerebrospinal fluid, however, potassium and magnesium levels were gradually risen during perfusion. 3) Potassium level of the striated muscle decreased during perfusion, but there was no change in potassium level. Potassium level of the liver remained unchanged. 4) Magnesium supplements during perfusion maintained electrolyte balance satisfactory, namely, urinary loss of potassium reduced and, therefore, hypokalemia was improved. It was concluded that magnesium supplements were recommended to be added to priming solution to improve potassium metabolism during and after extracorporeal circulation. en-copyright= kn-copyright= en-aut-name=EbaraYoshio en-aut-sei=Ebara en-aut-mei=Yoshio kn-aut-name=江原芳男 kn-aut-sei=江原 kn-aut-mei=芳男 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学第2外科教室 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=1033 end-page=1058 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Exfoliative, Cytological and Histological Studies on Healing Processes of the Socket after Extracting Deciduous Tooth of Pup kn-title=幼犬乳歯抜歯創治癒過程の剥離細胞学的および組織学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The healing processes of deciduous tooth socket after extraction seems to have some influence on the growth of permanent teeth. As for the studies on healing processes of extraction wound of teeth, there are many reports by Euler (1932), Hahn (1958), Smith (1958), and Tomozawa (1973), but as far as we know, there is no report dealing with deciduous teeth. For this reason, using pups (about 3 months old, weighing 1.5Kg-3.0Kg, about the same solidification of eruption of deciduous teeth and calcification of permanent teeth germ) the first and second frontal teeth of upper jaw of the right and left sides, and the first and third frontal teeth on the right and left sides were extracted. Then exfoliative cytological, pathohistological as well as macroscopic observations were carried out on the healing processes of the extraction wound with lapse of time, and the following results were obtained. It was found that 15 days after tooth extraction the maturity of epithelial cells became quite marked, and by 30 postoperative days exfoliated cells gave the findings similar to those of normal gingiva. The proliferation of the subepithelial connective tissue was marked by 5-10 postoperative days. After 20 days and later the exfoliative cytological findings revealed an acute increase in the number of precornified cells, and the pathohistological findings showed a tendency of parakeratosis. Macroscopic findings indicated a decrease in erythema, swelling and exudative substances, and the shrinkage of scar could be recognized by 15 days and thereafter. en-copyright= kn-copyright= en-aut-name=NishijimaKatsumi en-aut-sei=Nishijima en-aut-mei=Katsumi kn-aut-name=西嶋克巳 kn-aut-sei=西嶋 kn-aut-mei=克巳 aut-affil-num=1 ORCID= en-aut-name=KishiKanji en-aut-sei=Kishi en-aut-mei=Kanji kn-aut-name=岸幹二 kn-aut-sei=岸 kn-aut-mei=幹二 aut-affil-num=2 ORCID= en-aut-name=NagahataShunichiro en-aut-sei=Nagahata en-aut-mei=Shunichiro kn-aut-name=長畠駿一郎 kn-aut-sei=長畠 kn-aut-mei=駿一郎 aut-affil-num=3 ORCID= en-aut-name=MaedaKenichiro en-aut-sei=Maeda en-aut-mei=Kenichiro kn-aut-name=前田健一郎 kn-aut-sei=前田 kn-aut-mei=健一郎 aut-affil-num=4 ORCID= en-aut-name=SakuraiYoh en-aut-sei=Sakurai en-aut-mei=Yoh kn-aut-name=桜井洋 kn-aut-sei=桜井 kn-aut-mei=洋 aut-affil-num=5 ORCID= en-aut-name=KiguchiKenichiro en-aut-sei=Kiguchi en-aut-mei=Kenichiro kn-aut-name=木口健一郎 kn-aut-sei=木口 kn-aut-mei=健一郎 aut-affil-num=6 ORCID= en-aut-name=SuwakiSadayoshi en-aut-sei=Suwaki en-aut-mei=Sadayoshi kn-aut-name=洲脇貞吉 kn-aut-sei=洲脇 kn-aut-mei=貞吉 aut-affil-num=7 ORCID= en-aut-name=NagatsukaTakahito en-aut-sei=Nagatsuka en-aut-mei=Takahito kn-aut-name=長束崇仁 kn-aut-sei=長束 kn-aut-mei=崇仁 aut-affil-num=8 ORCID= en-aut-name=IshidaMotohisa en-aut-sei=Ishida en-aut-mei=Motohisa kn-aut-name=石田元久 kn-aut-sei=石田 kn-aut-mei=元久 aut-affil-num=9 ORCID= en-aut-name=SogawaKazuhiko en-aut-sei=Sogawa en-aut-mei=Kazuhiko kn-aut-name=十川和彦 kn-aut-sei=十川 kn-aut-mei=和彦 aut-affil-num=10 ORCID= en-aut-name=MotoiMakoto en-aut-sei=Motoi en-aut-mei=Makoto kn-aut-name=元井信 kn-aut-sei=元井 kn-aut-mei=信 aut-affil-num=11 ORCID= en-aut-name=OmoriHiroyuki en-aut-sei=Omori en-aut-mei=Hiroyuki kn-aut-name=大森浩之 kn-aut-sei=大森 kn-aut-mei=浩之 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部口腔外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第2病理学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第2病理学教室 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=1023 end-page=1032 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ⅱ. Histological Studies on Experimental Allergic Hepatitis with Appraisal of Mononuclear Cells in its Development kn-title=実験的アレルギー性肝炎の研究 第2編 同種肝抽出液感作リンパ球の移入による肝の組織変化 en-subtitle= kn-subtitle= en-abstract=In an attempt to evaluate the significance of mononuclear cells in the experimental allergic hepatitis which was previously studied, lymphocytes from inbred strain C(57) BL mice with the hepatitis was passively transfered into x-ray irradiated isologous mice. Early histological changes in the liver of the recipient mice consisted of an extensive coagulation necrosis on the 2nd or 3rd day after the transfer, and delayed changes occurring on the 7th to 10th post-transfer day included a marked infiltration of mononuclear cells in the portal areas, various types of liver cell necrosis and degeneration, a mononuclear cell infiltration in the sinusoid as well as an activation of the Kupffer cells as compared with control groups. These histological changes, however, were transient and subsided in 2 to 3 weeks post to the transfer of the cells. There was no tendency to the development of a feature of chronic hepatitis. The present experiment indicated that the passive transfer of sensitized lymphocytes obtained from mice with the experimental allergic hepatitis made by the previous experiment produced an allergic hepatitis comprising a coagulation necrosis and others in isologous mice, but this hepatitic change was transient and by no means transformed to a chronic status similar to a human chronic hepatitis as in the previous experiment. kn-abstract=ヒトの肝炎の進展,慢性化の過程において,肝のグリソン鞘に浸潤している単核細胞がいかなる役割を果しているかを究明する一つの試みとして, complete Freund's adjuvant添加同種肝抗原でC57Blマウスを長期感作して実験的アレルギー性肝炎を作成し,感作C57Blマウスの脾およびリンパ節より感作リンパ球を分離し,レントゲン全身照射後の同系マウスに移入し,受動転嫁実験を実施した.その結果,対照群に比して,39例中15例に肝の組織変化を認めた.そのうち,早期すなわち移入後2～3日目に発生した広範な凝固壊死を14例中3例に,やゝ遅れた時期すなわち移入後5～8日目に発生したpiecemeal necrosisを主体とする変化を25例中2例に認め,それらの変化は感作リンパ球による肝細胞性壊死であることを強く示唆した.以上の肝の組織変化はヒトのウイルス性肝炎の組織所見に類似しており, B型肝炎発症における主要因の1つ,すなわちHB抗原感作リンパ球の果す意義にも関連して重要な実験成績であると考えた. en-copyright= kn-copyright= en-aut-name=HirataHiroaki en-aut-sei=Hirata en-aut-mei=Hiroaki kn-aut-name=平田弘昭 kn-aut-sei=平田 kn-aut-mei=弘昭 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=1009 end-page=1021 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ⅰ. Histological Studies on Experimental Hepatitis after Sensitization with Homologous Liver Extract kn-title=実験的アレルギー性肝炎の研究 第1編 AKRマウス肝抽出液によるC57Blマウス長期感作後の組織学的変化 en-subtitle= kn-subtitle= en-abstract=In an attempt to evaluate histologically an allergic phenomenon involved in the development of chronic hepatitis in man, the inbred strain C57BL mice were sensitized for prolonged durations from 5 to 19 weeks with a homologous liver extract from AKR mice as well as with complete Freund's adjuvant. Histological changes in the liver of the sensitized mice immediately after the treatment comprised a marked round cell infiltration in the portal areas, piece-meal necrosis, various types of liver cell necrosis and degeneration, and an activation of the Kupffer cells as compared with control groups. These histological changes somewhat resembled the findings of chronic hepatitis in human liver disease, but they have greatly subsided in 5 weeks post to the last sensitization. It may be assumed on the basis of the present experiment that a persistent sensitization for a longer duration is necessitated for the establishment of a chronic murine hepatitis similar to a human chronic hepatitis. kn-abstract=ヒトのウイルス性肝炎の発症および慢性化のアレルギー性機序を解明するための一手段として, AKR肝抽出液を抗原としてC57Blに長期感作を施行し,肝グリソン氏鞘内に著明な円形細胞浸潤,piecemeal necrosis,肝細胞壊死,星細胞の反応を作成しえたが,リンパ沪胞の形成,肝グリソン氏鞘の結合織の増生は認められなかった.以上の組織変化は肝炎B抗原,すなわち,　hetero抗原とその抗体とのアレルギー機序によって生じると考えられるヒトのウイルス性肝炎の組織表現にかなり類似している.しかし,長期感作を中止し放置すると,組織変化は消褪した. en-copyright= kn-copyright= en-aut-name=HirataHiroaki en-aut-sei=Hirata en-aut-mei=Hiroaki kn-aut-name=平田弘昭 kn-aut-sei=平田 kn-aut-mei=弘昭 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 END start-ver=1.4 cd-journal=joma no-vol=87 cd-vols= no-issue=11-12 article-no= start-page=993 end-page=1008 dt-received= dt-revised= dt-accepted= dt-pub-year=1975 dt-pub=19751230 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Significance of Negative T wave in Lead aVL kn-title=心電図の(a)V(L)誘導の陰性T波に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The negative T wave in lead aVL is one of the electrocardiographic features of left ventricular hypertrophy or myocardial infarction, associated with negative T wave in lead v(5), v(6) and Ⅰ. Whereas the significance of isolated negative TaVL, not associated with other abnormal negative T wave, is of much controversial. The electrocardiographic and vectorcardiographic changes of 146 cases were studied for appreciation of negative TaVL, whose TaVL were negative in 115 cases with or without negative ST, Tv(5), v(6), positive in 23 cases, and flat in 7 cases. The electrocardiographic diagnosis of left ventricular hypertrophy was found in 50 cases, of old myocardial infarction, in 24 cases, and the remaining were admitted to R(Ⅰ)>R(Ⅲ) group (41 cases) and to R(Ⅰ)R(Ⅲ) group, if associated with isolated negative TaVL, T(Ⅲ)>T(Ⅰ) and TV(Ⅰ)/TV(5)≥0.74, the same displacement as in left ventricular hypertrophy and myocardial infarction was found, suggesting ischaemic change of lateral wall. In R(Ⅰ)T(Ⅰ) and TV(Ⅰ)/TV(5)≥0.56, the spatial T loop was in anterior position, but with no pathological meaning. Negative TaVL associated with R(Ⅰ)>R(Ⅲ), T(Ⅲ)>T(Ⅰ) and TV(Ⅰ)/TV(5)<0.74 or R(Ⅰ)T(Ⅰ) and TV(Ⅰ)/TV(5)<0.56, was sign of inferior, posteroinferior, posterior or normal position of spatial T loop, and abnormal T loop (spatial length/width≤2.6, abnormal speed of inscription, irregular shape, wide spatial QRS-T angle) was found more frequent in R(Ⅰ)>R(Ⅲ) group (66.7%) than in R(Ⅰ)