start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=219 end-page=230 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Studies on Chronic Leukemia Part 2. Clinical statistics of chronic lymphoid leukemia kn-title=慢性白血病に関する臨床的研究 第2編 教室における慢性リンパ性白血病の臨床統計 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We made clinical statistical observations of the 8 cases of chronic lymphoid leukemia admitted to our clinic during the period of 16 years from 1952 to 1967, and obtained the following results. 1. Five out of the 8 cases were in advanced age of over 55 years old of which the ratio of male to female was 3:1. 2. We found no noteworthy episode in the family of the patients but one of the 8 cases proved to have had a secondary atomic bomb irradiation (i.e. irradiation after the bomb explosion). 3. In our various examinations of the patients to their history, symptoms and others, the results were approximately similar to those reported in JAPAN and other countries previously. 4. The growth pattern of lymph node tissue culture in all cases was similar to those of bone marrow in patients with acute lymphocytic leukemia. However, the growth zone was mainly consisted of mature small lympocytes. 5. The growth pattern of bone marrow in 7 out of 8 cases was similar to those of bone marrow in patients with chronic myelogenous leukemia (i.e.: double zone). However, the inside of double growth zone was mainly consisted of mature lymphocytes densely and the outside a small number of granulocytic cells. en-copyright= kn-copyright= en-aut-name=IzumiHiroyuki en-aut-sei=Izumi en-aut-mei=Hiroyuki kn-aut-name=和泉裕之 kn-aut-sei=和泉 kn-aut-mei=裕之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=197 end-page=217 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical Studies on Chronic Leukemia Pert Ⅰ.Statistics of chronic myelogenous leukemia with special reference to acute exacerbation kn-title=慢性白血病に関する臨床的研究 第1編 教室における慢性骨髄性白血病の臨床統計，特に急性転化を中心として en-subtitle= kn-subtitle= en-abstract= kn-abstract=We took statistics of the 64 cases of chronic myelogenous leukemia admitted to our clinic during the past 16 years from the beginning of 1952 to the end of 1967 and studied them carefully with special reference to the criteria for early diagnosis of acute exacerbation and correlation between the acute exacerbation and the bone marrow culture of patients. As a result we obtained some new findings as follows. 1. Hematological and clinical criteria suggesting acute exacerbation prior to the appearance of hiatus leukemics in peripheral blood and/or bone marrowpictures are: (1) there is an increase of over 5% of myeloblasts in the peripheral blood and/or bone marrow: (2) an increase of over 20% of promyelocytes in the above mentioned pictures: (3) an increase of more than 5% of basophils in the above mentioned pictures: (4) a decrease of erythrocyte count below 3,000,000: (5) a decrease of platelet count below 100,000: (6) so called "dry tap" in the bone marrow: (7) as the clinical symptoms we find splenomegaly, a tendency to bleed, high grade fever, hepatomegaly, swelling of lymph nodes, general malaise, loss of appetite, and acute severe pain in the extremities.: and the growth pattern of the bone marrow tissue culture devised in our clinic approaches to the pattern of acute leukemia. In any case where three or more findings memtioned above are recognized, we can strongly suspect an acute exacerbation. 2. In the group treated with anti-leukemic drugs until the bone marrow culture showed 'hypoplastic pattern' the percentage of acute exacerbation proved to be 64.7% and the median survial time was 30.6 months, while in the group in which the treatment was shifted to maintenance therapy with minimum dosis of anti-leukemic drugs as soon as the bone marrow culture reached 'normal pattern', the percentage of acute exacerbation was 48.5% and the median survival time 37.6 months. These findings seem to suggest that chemotherapy of chronic myelogenous leukemia should be carried out tenderly with minimum dosis of anti-leukemic drugs and it should be maintained to the degree not so as to　induce 'hypoplastic pattern' of bone marrow. en-copyright= kn-copyright= en-aut-name=IzumiHiroyuki en-aut-sei=Izumi en-aut-mei=Hiroyuki kn-aut-name=和泉裕之 kn-aut-sei=和泉 kn-aut-mei=裕之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=185 end-page=195 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study on Temporary Loss or Retardation of Body Weight among Babies kn-title=乳児の一時的体重停滞に関する衛生学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There have been many works concerning health indicators for babies, but we can not find so many works which discuss about interrelations between socio-economical and cultural background of babies and health indicators used in the field of community health practice. The 420 objects were selected to be discussed among the babies at the area regulated by a certain health center, who were born during January 1st to December 31st in 1967. The author demonstrated that some life conditions of babies had very important impacts to a temporary loss or retardation of body weight among babies, such as birth weight, birth order, mother's age, mother's occupation and so forth. The results are as follows. 1) There were observed more frequently loss or retardation of body weight among babies with 2,500 gr or less and 3,501 gr or more birth weight. 2) In connection with birth order, there were observed less loss or retardation of body weight among the first born babies than others. 3) A group of mothers from 25 to 32 of ages had less babies of temporary loss or retardation of body weight than other groups. 4) The author pointed out that the younger mother she was, the more often her baby had loss or retardation of body weight during its weaning period. 5) There were observed more temporary loss or retardation of body weight among bosom fed babies, especially whose mother had engaged to agricultural work all day long than others. 6) Public health nurses were apt to find medical reasons only and miss socio-economical and cultural background for temporary loss or retardation of body weight among babies. en-copyright= kn-copyright= en-aut-name=NakamuraHitoshi en-aut-sei=Nakamura en-aut-mei=Hitoshi kn-aut-name=中村仁志 kn-aut-sei=中村 kn-aut-mei=仁志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学大学院医学研究科社会医学系衛生学専攻 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=173 end-page=183 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Public Health Approach to Etiology of Cerebrovasular Accidents kn-title=脳卒中の発生要因に関する衛生学的知見 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Though there are many studies of cerebrovascular accidents from etiological point of view, few have been reported concerning impacts of daily life to cerebrovascular accidents from the view point of public health. The author examined the interactions between human factors and his environment in the cases of cerebrovascular accidents in two areas and one group of workers. The 227 objects were selected to discuss from the patients and the dead in two rural areas by examining answeres to questionnaires, medical records by doctors, and dath certificates. The results are as follows. 1) There was a difference of incidence of cerebrovascular accidents between those two areas it was 4.35 per 1,000 adults over 40 years in Kayo, whereas 6.20 in Yao. 2) Cerebrovascular accidents often occurred at either dinning and bath room in the evening or toilet in the midnight. 3) The impacts of climate was not clear in Yao where the climate is calm, on the conrary there were observed two peaks of incidence in summer and winter in Kayo where the climate is sever. 4) There were found more frequently cerebral hemorrahge than cerebral thrombosis among male farmers in those two areas. 5) The author pointed out that not only natural impacts but also soci-economical and cultural background to cerebrovascular accidents must be discussed, such as organization of labour and so forth. 6) There were observed the evidence that chronic CS(2) exposure resulted in high incidence of hypetention and cerebrovascular accidents. en-copyright= kn-copyright= en-aut-name=UehataTetsunojo en-aut-sei=Uehata en-aut-mei=Tetsunojo kn-aut-name=上畑鉄之丞 kn-aut-sei=上畑 kn-aut-mei=鉄之丞 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部大学院社会医学系衛生学専攻 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=147 end-page=158 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Induced-Resistance and Cross-Tolerance to Some Histamine Releasers kn-title=Histamine遊離物質にたいする抵抗性の誘導と交叉耐性に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=When histamine releasers such as sinomenine, compound 48/80, PVP and Tween 20 were given intravenously by a series of injections in the scheduled doses increasing very gradually from a minute amount, dogs were made resistant against the shock doses of respective releaser while there were no significant changes both in the arterial blood pressure and in the plasma histamine level, i.e. no evidence of histamine release during the procedure. These resistant dogs responded well to intravenous injection of histamine as in the normal dog. The dogs made resistant to compound 48/80 were found also to be resistant to sinomenine and vice versa (cross tolerance). A cross-tolerance was also noticed between PVP-and Tween 20-resistant dogs. However, the dogs resistant to sinomenine and to 48/80 reacted to both PVP and Tween 20 as normal dogs. And the same was held in the converse. Similar findings were also seen in the skin reaction and in the histamine release from the chopped skin by these histamine releasers. In neither of these two groups of the resistant dogs, anaphylactic shock and peptone shock were inhibited. The mechanisms leading, to a resistance against a certain releaser by repeating the injections of it were discussed and it was assumed that a family of histamine releasers of different chemical structures possibly share a common site of action on the surface of mast cell membrane. en-copyright= kn-copyright= en-aut-name=KomotoShigemitsu en-aut-sei=Komoto en-aut-mei=Shigemitsu kn-aut-name=古元重光 kn-aut-sei=古元 kn-aut-mei=重光 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部薬理学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=135 end-page=145 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histamine Release by Toluidine Blue from IsolatedRat Mast Cells kn-title=Toluidine Blueによる肥満細胞からのHistamine遊離機構 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Toluidine blue released histamine from isolated rat mast cells suspended in a buffered physiological solution at 37℃, in concentrations ranging from 10 to 250μg/ml. The highest histamine release was seen at concentrations from 50 to 100μg/ml. In concentrations between 25 and 50μg/ml, mast cells responded with a typical degranulation quite similar to that seen under the action of 0.5μg/ml of compound 48/80, while at 100μg/ml the cell surface showed indentation with a number of small protrusions in which the granules were occasionally contained. However, a smooth cell surface was seen in higher concentrations over 100 μg/ml of toluidine blue. This indicates that toluidine blue releases histamine without accompanying degranulation. When the time course of histamine release was determined by abrupt cooling to stop the reaction at various time sequence, it was shown that histamine release at 37℃ is a very rapid process actually accomplishing within 5 sec. All morphological changes of mast cell completed at longest within 15 sec after the addition of toluidine blue, while the dye could not be seen inside the cytoplasm before 1 min after the addition. These observations suggest that toluidine blue reacts with receptive sites on the cell surface of mast cell and this may trigger the further processes leading to the histamine release as well as to morphological changes. The histamine release by toluidine blue was inhibited by respiratory inhibitors or uncouplers of oxidative phosphorylation and these inhibitions were overcome by the presence of lucose. Toluidine blue released histamine from the mast cells of rat mesentery but the effective concentrations were higher than that in the isolated mast cells. In the dog, a large amount of toluidine blue injected i. v. caused a severe hypotension, but there was no marked increase in the plasma histamine differing from the action of compound 48/80. With respect to the mechanisms of histamine release the mode of action of toluidine blue may be in common to that of other basic histamine releasers, although distinct difference existed in some aspects of the action between toluidine blue and compound 48/80. en-copyright= kn-copyright= en-aut-name=KomotoShigemitsu en-aut-sei=Komoto en-aut-mei=Shigemitsu kn-aut-name=古元重光 kn-aut-sei=古元 kn-aut-mei=重光 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部薬理学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=127 end-page=134 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Postnatal Development of Lymphoid Tissues in the Mouse kn-title=マウスにおけるリンパ性組織の生後発生 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The processes of pastnatal development of lymphoid tissues in the mouse were studied. It was found that the weight of the thymus reaches its maximum at 5 weeks of age and decrease gradually thereafter, whereas the maximal weights of the mesenteric lymph nodes and spleen are attained at 4 mothes of age, declining thereafer rather rapidly. The secondary nodules of the Flemming type, having germinal centers, were found to develop during the period between 2 and 6 weeks after birth in the mesenteric lymph nodes, as well as in the white pulp of the spleen. In the splenic red pulp, an extensive erythropoiesis was observed to occur during the peried from bith to the 5th weeks after birth. Such erythropoiesis in the red pulp was found to disappear nearly completely during the period between 6 weeks and 4 months of age and to reappear in the ages older than 5 mothes after birth. en-copyright= kn-copyright= en-aut-name=OsogoeBunsuke en-aut-sei=Osogoe en-aut-mei=Bunsuke kn-aut-name=尾曽越文亮 kn-aut-sei=尾曽越 kn-aut-mei=文亮 aut-affil-num=1 ORCID= en-aut-name=OhmuraMorito en-aut-sei=Ohmura en-aut-mei=Morito kn-aut-name=大村守人 kn-aut-sei=大村 kn-aut-mei=守人 aut-affil-num=2 ORCID= en-aut-name=ImamuraHidetoshi en-aut-sei=Imamura en-aut-mei=Hidetoshi kn-aut-name=今村英俊 kn-aut-sei=今村 kn-aut-mei=英俊 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=京都大学医学部解剖学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部解剖学教室 affil-num=3 en-affil= kn-affil=山口大学医学部解剖学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=119 end-page=126 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Effects of Lymphatic Obstruction upon the Immune Response of a Lymph Node kn-title=リンパ節の免疫反応に及ぼすリンパ流遮断の影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In an attempt to localize an antigen in a single lymph node, sheep erythrocytes were injected directly into a single popliteal lymph node of an adult rabbit by way of an afferent lymphatic, after blocking all its lymphatics. The condition of complete obstruction of the lymphatic drainage through the injected popliteal node was maintained for a period as long as 14 days. Evidence was obtained to indicate that the injected antigen, if given in appropriate low doses, was localized completely in the injected popliteal node. Subsequent to antigenic stimulation, a primay immune response developed, with proliferative reaction of antibody-producing cells which was also confined to the stimulated popliteal node almost completely. Despite complete obstruction of the lymphatic pathways of the stimulated popliteal node, the serum antibody titers were considerably raised, though to a lesser extent than in the control animals in which the lymphatic drainage of the antigen-stimulated popliteal node was left intact. The possible ways of transport of antibody from the antigen-stimulated lymph node to the general circulation were discussed. en-copyright= kn-copyright= en-aut-name=OsogoeBunsuke en-aut-sei=Osogoe en-aut-mei=Bunsuke kn-aut-name=尾曽越文亮 kn-aut-sei=尾曽越 kn-aut-mei=文亮 aut-affil-num=1 ORCID= en-aut-name=OhmuraMorito en-aut-sei=Ohmura en-aut-mei=Morito kn-aut-name=大村守人 kn-aut-sei=大村 kn-aut-mei=守人 aut-affil-num=2 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一解剖学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一解剖学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=111 end-page=117 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Reactivity of Lymph Node. The Influence of Antigenic Stimulation upon the Blood Vascular Architecture of Lymph Node kn-title=リンパ節の反応性に関する研究―とくにリンパ節の血管構築に及ぼす抗原刺激の影響― en-subtitle= kn-subtitle= en-abstract= kn-abstract=The influence of antigenie stimulation upon the blood vascular architecture of the popliteal lymph node in the rat and rabbit was studied by the injection method, after injecting either sheep blood or complete Freund's adjuvant into the footpad of a hind leg. The popliteal nodes on the opposite side remained unstimulated and served as controls. Chief findings are as follows. 1. After antigenic stimulation many areas undergoing hyperplasia appear in the cortex of the stimulated nodes. 2. Such areas are characterized by scanty and coarse vascular mesches and much greater caliber of the blood vessels than in other areas. 3. In the areas which are not undergoing hyperplasia, the meshes of blood vessels are very fine and the caliber of such blood vessels are much smaller than in the areas undergoing hyperplasia, en-copyright= kn-copyright= en-aut-name=OhmuraMorito en-aut-sei=Ohmura en-aut-mei=Morito kn-aut-name=大村守人 kn-aut-sei=大村 kn-aut-mei=守人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1解剖学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=101 end-page=110 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A Study of the Cytoplasmic Bodies Occurring in Lymphoid Tissues kn-title=リンパ性組織に出現する細胞質小体（cytoplasmic bodies）に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The occurrence of cytoplasmic bodies in lymphoid tissues of mammals was first described by Downey and Weidenreich (1912). Concerning the significance of occurrence of these bodies, however, little is know at present. In the present study, the mode of occurrence of these bodies in imprints and sections of lymphoid tissues of rabbits, mice and young chickens was investigated, in relation to the functional differentiation of lymphoid tissues into the central and the peripheral ones. The chief findings are as follows: 1. In the peripheral lymphoid tissues, such as lymph nodes and spleen (splenic white pulp), cytoplasmic bodies of varying size are found in large numbers, whereas they are scanty in the central lymphoid tissues such as the thymus, although in the appendix and sacculus rotundus of rabbits, as well as in the bursa of Fabricius of young chickens, they are not so few as in the thymus. 2. Cytoplasmic bodies stained red by methyl green-pyronin, after fixing in Carnoy's fluid. They are chiefly composed of pyroninophilic granules or threads. They vary greatly in size, from the size of blood platelets to that of small lymphocytes. After digestion of the samples with RNase, the pyroninophilia of these bodies disappeared completely. Feulgen reaction is negative in these bodies. 3. In the lymph nodes and spleen, which had previously been stimulated by antigen, cytoplamic bodies occurred in much greater numbers than in the unstimulated control tissues. en-copyright= kn-copyright= en-aut-name=OhmuraMorito en-aut-sei=Ohmura en-aut-mei=Morito kn-aut-name=大村守人 kn-aut-sei=大村 kn-aut-mei=守人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第1解剖学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=91 end-page=99 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Histochemical studies on the irradiation carcinoma of the uterine cervix kn-title=放射線照射子宮頸癌の組織化学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Histological and histochemical changes of the cervix by irradiation were investigated on 16 cases of carcinoma of the cervix. Maximum surface dose, 2,000-6,000R., was applied to the cervix with a special colpostat followed by radical hysterectomy 1-10 days later. The difference between irradiated areas and non irradiated areas was studied with following results. 1) The activity of non specific esterase increased in irradiated areas with expectation of a useful indicator of radiosensitivity. 2) SDH, LDH and G-6-P DH showed no change in their activity after irradiation. 3) The appeareance of mast cells has some relation with histological radiation effect. Increase of mast cells in number was noticed in good histological response. en-copyright= kn-copyright= en-aut-name=HashimotoTakeo en-aut-sei=Hashimoto en-aut-mei=Takeo kn-aut-name=橋本威郎 kn-aut-sei=橋本 kn-aut-mei=威郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産科婦人科教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=81 end-page=90 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Phonocardiographic Studies on Hypertensive Part Ⅱ Phonocardiogram of the Hypertensive by Inhalation of Amyl-Nitrite kn-title=高血圧症の心音図学的研究 第2編 高血圧症の亜硝酸アミル吸入負荷心音図 en-subtitle= kn-subtitle= en-abstract= kn-abstract=PCG and ECG using Amyl-Nitrite were studied in 74 cases of the hypertensive with maximum blood pressure more than 150 mmHg or minimum blood pressure more than 90 mmHg. Twenty five cases of the health were chosen as control. The following results were obtained. 1) Blood pressure showed the lowest near 15 sec after inhalation of Amyl-Nitrite and puls rate was the most markedly increased near 30 sec after. The same results were found in the health. At the period of manifestations in function of` the Amyl-Nitrite, were not found significant differences with maximum, minimum and mean blood pressure measured before ihalation. 2) Duration of the first sound was tend to prolong in the hypertensive (0.076±0.020sec), less prolonged in the health (0.065±0.016 sec). This prolongation was not correlated with maximum and minimum blood pressuse measured before inhalation. 3) Cases showed absolute shortening of the QⅡ interval were increased in the hypertensive. Those shortenings were correlated with LVH. As QII interval was shortened as QⅡ/QT. ratio was decreased. 4) Protodiastolic gallop sound (accentuation of the third heart sound) became significant after inhalation in the hypertensive, and was correlated with LVH. 5) Atrial gallop sound (accentuation of the atrial sound) was accentuated after inhalation in the hypertensive, too. This fact was in discordance with the old reports. The accentuation was connected with LVH. 6) Duration of apical systolic murmur was prolonged in the hypertensive lasting 60 sec after inhalation, and it's amplitude was increased. Some cases showed a new murmur after inhalation. 7) Increase of the amplitude was correlated with ST-T change and accentuation of atrial gallop sound. However, mechanism of Amyl-Nitrite for the accentuation of murmur remained uncertain. en-copyright= kn-copyright= en-aut-name=TenetaniSetsuro en-aut-sei=Tenetani en-aut-mei=Setsuro kn-aut-name=種谷節郎 kn-aut-sei=種谷 kn-aut-mei=節郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=69 end-page=80 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Phonocardiographic Studies on Hypertensive Part Ⅰ Phonocardiogram of the Hypertensive kn-title=高血圧症の心音図学的研究 第1編 高血圧症の心音図 en-subtitle= kn-subtitle= en-abstract= kn-abstract=PCG and ECG were studied in 118 cases of the hypertensive with maximum blood pressure more than 150 mmHg or minimum blood pressure more than 90 mmHg. Fifty two cases of the health were chosen as control. The following results were obtained. 1) Duration of the first sound was 0.073±0.017 sec in the hypertensive and 0.067±0.019 sec in the health. So much maximum or minimum blood pressure rose, duration of the first sound prolonged. 2) In the hypertensive, although it is not so-called Hegglin's syndrome, an actually measured QⅡ interval was shortened and an actually measured QT interval was prolonged. As a result, QⅡ/QT ratio became small coresponding with elevation of maximum or minimum blood pressure and with deterioration of electrocardiographic sign. From the point of view to separate mechanical work from electoric action of the heart, therefore, it is possible to estimate the functional state of the heart. 3) Protodiastolic gallop sound (accentuation of the third heart sound) was recorded in the hypertensive more often than in the health. That was recorded more often at the Erb's area than at the apex in the hypertensive, and in the health, more often at the apex than at the Erb's area. From the above, together with correlation of electrocardiographic sign, it was thought that the protodiastolic gallop sound was participated in dysfunction of atrioventricular valve due to left ventricular myocardial failure. 4) Frequency of the protodiastolic gallop sound was recorded highly in the cases with ST. T change and the LVH plus ST. T change. This fact was regarded as increase of the relative diastolic overloading. 5) Frequency of the apical systolic murmur was 83% in the hypertensive and 53% in the health. Those murmurs were all plateau or diamond shape ejection murmur. Therefore, the hypertensive cardiac failure might not be caused by relative mitral insufficiency, but by myocardial ischemic change. Degree of the hypertensive and cardiac function of the hypertensive were inferable with this study. en-copyright= kn-copyright= en-aut-name=TenetaniSetsuro en-aut-sei=Tenetani en-aut-mei=Setsuro kn-aut-name=種谷節郎 kn-aut-sei=種谷 kn-aut-mei=節郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=55 end-page=68 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on the Speech and Language Development in Children With Impaired Hearing Part Ⅱ On the Development of Speech and Language of the Children in the Special Class for the Hard of Hearing kn-title=難聴児の言語発達に関する研究 第2編 難聴学級児童の言語発達について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Of the 17 handicapped pupils, 15 of them were sensori-neural and 2 of them were mixed type hearing loss, all having 42-82 db hearing loss in average of speech range and educated in the special class for hard of hearing over one year. Examinations were made as to their past history, audiometry, effects of hearing aid with lipreading, intelligibility of monosyllables, words and sentences, and hearing acuity, conversation intelligibility, sentence structure and training effect, and those results were compared with those in preceding one year. Principal findings are summarized as follows: 1) Articulation score of monosyllables of the pupils educated for over one year in the special class for hard of hearing was found to be 92.0% in maximum, 38.7% in minimum and 65.9% in average of the total pupils, in contrast to 85.0% in maximum, 26.7% in minimum and 52.4% in average of the total pupils in previous one year. 2) The articulation score at the first examination was in such an order as the articulation score of monosyllables 52.4% in average, of sentences 71.8% and of words 74.1%, and in the second year examination, the articulation score of monosyllables 65.9%, of words 81.0% and of sentences 84.5% . From the above results, it seems to be clear that articulation score can be improved with the hearing and speech training even in the perceptive deaf children. 3) In the all 17 pupils examined including 5 pupils who educated for one year at the special class, the articulation score of monosyllables have a inverse correlation with the level of hearing loss, and this is more marked in only the 12 pupils with over 2 years' education. 4) The pupils whose articulation score of sentences were found to be 100% had showed their average hearing in speech range in 42-67 db loss, and their articulation score of monosyllables were in 56.0% -75.3%. 5) It is found that those pupils with over three years' speech and language training could master themselves to utilize fully their articulation capabilities in pproportion to their hearing level. 6) It is concluded that for the children with impaired hearing the basic training for speech accompanied by language training should be started by the age of 3 years at the latest and completed before entering the primary school, and in the special class for such children the emphasis should be placed more on phrases and sentences rather than on monosyllbales and words. en-copyright= kn-copyright= en-aut-name=OhueHiroshi en-aut-sei=Ohue en-aut-mei=Hiroshi kn-aut-name=大山浩 kn-aut-sei=大山 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 END start-ver=1.4 cd-journal=joma no-vol=82 cd-vols= no-issue=3-4 article-no= start-page=41 end-page=54 dt-received= dt-revised= dt-accepted= dt-pub-year=1970 dt-pub=19700430 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on the Speech and Language Development in Children With Impaired Hearing Part 1 On Development of Speech and Language following Operative Hearing Restoration in Deaf Children with Congenital Malformation Ear kn-title=難聴児の言語発達に関する研究 第1編 両側伝音系奇形耳による難聴児の手術的聴力改善後の言語発達について en-subtitle= kn-subtitle= en-abstract= kn-abstract=For the purpose to determine what effects operative hearing restoration would hays on the speech and language development, this study was carried out on 13 cases of deaf children aged 8-16 years with bilateral congenital middle ear malformation whose hearing acuity was restored within 30 db loss in average of speech range by standard fenestration operation or stapes surgery and maintained one year after the operation. Examination was carried out on the hearing ability, intelligence, lipreading, intelligibility of articulation for monosyllables, words and sentences, conversation intelligibility, sonagram of monosyllables, time of reading, total disfluency index, vocabulary and sentence structures, and these results after the operation were compared with those before the operation. The results of the study briefly presented in the following. 1) The articulation score for monosyllables, words and sentences by pronounciation was moderately improved except in two children of delayed mental development. The obtained articulation score was in the ascending order of monosyllables, words and sentences. 2) In two children with delayed mental development the articulation score improvement was only slight as compared with the other children. 3) With exception of two cases the operation for hearing restoration was found to have increased the articulation score for syllables more than fifty percent. 4) The intelligence quotient, conversation intelligibility and total disfluency index were not improved so much as expected. 5) The number of childrens' vocabulary increased markedly after the operation. 6) For the development of speech and language in deaf children with bilateral malformation of conductive apparatus, it is desirable to diagnose as early as possible in order to enable earlier operation for hearing improvement. en-copyright= kn-copyright= en-aut-name=OhueHiroshi en-aut-sei=Ohue en-aut-mei=Hiroshi kn-aut-name=大山浩 kn-aut-sei=大山 kn-aut-mei=浩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部耳鼻咽喉科学教室 END