start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=631 end-page=635 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Measurement of Human Blood Catalase Activity and the Screening Method of Hypocatalasemia by Spectrophotometry Part 4. A simple method of measuring human blood catalase activity and the screening test for hypocatalasemia kn-title=分光光度法による人血液カタラーゼ活性の定量および低カタラーゼ血液症のスクリーニング法について 第4編 本法による活性の直接定量法と低「カ」血症のスクリーニング法 en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is generally accepted that modified Euler-Josephson's method of titration gives the value of catalase activity, “Kcat” as the standard value. Whereas by the author's method taking the value of catalase activity as "k" measured, for example, at room temperature, recorded on an autorecording apparatus, it will be seen that we get the formula, Kcat=1/1.035 (100/90K+0.513) The present study has led to the following conclusions: This method is characterized by the fact that it is useful for the screening test for hypocatalasemia as well as for simultaneous measurement of the catalase activity in human blood. It is suggested that the level of the screening be fixed more appropriately at 2.4. Attempts have been made to use a portable UV-colorimeter to the screening but it seemed that this apparatus is not suitable for the purpose. This method can measure not only the activity of purified catalase but also that of a partially purified catalase. It can also be applied for the measurement of catalase activity in tissues other than blood. It is anticipated that this method can also be useful for the investigation of hypocatalasemic blood catalase from the aspect of enzyme kinetics. en-copyright= kn-copyright= en-aut-name=NakagawaYoshito en-aut-sei=Nakagawa en-aut-mei=Yoshito kn-aut-name=中川嘉人 kn-aut-sei=中川 kn-aut-mei=嘉人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=625 end-page=630 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Measurement of Human Blood Catalase Activity and the Screening Method of Hypocatalasemia by Spectrophotometry Part 3. Evaluation of UV method supplemented with basic experiments on the measurement of human blood catalase activity kn-title=分光光度法による入血液カタラーゼ活性の定量および低カタラーゼ血液症のスクリーニング法について 第3編 本法の検討と活性測定に関する基礎的実験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The present communication deals with the principle of measuring and calculating the catalase activity of human blood by UV method. Under the conditions previously described, it has been clarified that the reaction of catalase-hydrogen peroxide practically follows the first order kinetics within 30-120 seconds. The velocity constant, k, seems to have no concern with the substrate concentration within the range of 0.005-0.025 mole. Catalase values, Kcat, measured under room temperature, are about 10% lower than those taken at 37℃. It has been found that measurements of the catalase activity have to be taken within 5 minutes after hemolysis en-copyright= kn-copyright= en-aut-name=NakagawaYoshito en-aut-sei=Nakagawa en-aut-mei=Yoshito kn-aut-name=中川嘉人 kn-aut-sei=中川 kn-aut-mei=嘉人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=619 end-page=623 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Measurement of Human Blood Catalase Activity and the Screening Method of Hypocatalasemia by Spectrophotometry Part 2. Measurement of human blood catalase activity by spectrophotometry with a temperature controlled cell chamber and autorecorder kn-title=分光光度計による人血液カタラーゼ活性の定量および低カタラーゼ血液症のスクリーニング法について 第2編 恒温ならびに自記記録装置を装着して正常及び低「カ」血症血液の測定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaYoshito en-aut-sei=Nakagawa en-aut-mei=Yoshito kn-aut-name=中川嘉人 kn-aut-sei=中川 kn-aut-mei=嘉人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=613 end-page=618 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Measurement of Human Blood Catalase Activity and the Screening Method of Hypocatalasemia by Spectrophotometry Part 1. Measurement of Human Blood Catalase Activity by Spectrophotometry (with a Hitachi GPO Model) kn-title=分光々度法による人血液カタラーゼ活性の定量および低カタラーゼ血液症のスクリーニング法について 第1編 直読式分光々電光度計による正常血カタラーゼ活性の測定 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NakagawaYoshito en-aut-sei=Nakagawa en-aut-mei=Yoshito kn-aut-name=中川嘉人 kn-aut-sei=中川 kn-aut-mei=嘉人 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=601 end-page=612 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental Studies in Viability of the Kidney Preserved Under Hyperbaric and Hypothermic Condition kn-title=低温高圧酸素下腎保存に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Experimental studies on viability of the kidney preserved under hyperbaric and hypothermic condition were performed on dogs. The left kidney was removed and perfused with refrigerated (4℃.)low molecular weight dextran in electrolytic solution containing heparin. Immediately after perfusion, the kidney was immersed in a same solution as used for perfusion and stored in a hyperbaric chamber for 6, 12 and 24 hours, respectively under 3 atmospheres of oxygen pressure and 4℃. Following the storage, the kidney was reimplanted in the left iliac fossa of the original donor. The contralateral kidney was removed 3 weeks after the renal autotransplantation. Following results were obtained. 1) Perfusion of the kidney with low molecular weight dextran in electrolytic solution resulted in no significant increas of the kidney weight and in no development of interstitial edema. 2) There was no correlation between the histologic appearance of the preserved kidney and its viability. 3) After the contralateral nephrectomy all two kidneys preserved for 6 hours and two out of three kidneys preserved for 12 hours were able to sustain life but all 9 kidneys preserved for 24 hours were unable. 4) The precise role played by hyperbaric oxygenation in these experiments was difficult to asses but hyperbaric oxygenation has beneficial effect on renal preservation and limitation of preservation time was considered between 12 and 24 hours. en-copyright= kn-copyright= en-aut-name=HiraiJunichi en-aut-sei=Hirai en-aut-mei=Junichi kn-aut-name=平井淳一 kn-aut-sei=平井 kn-aut-mei=淳一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2外科教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=587 end-page=600 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effect of Chloroquine, a Derivative of Quinoline, on the Function of the Digestive System. Part. 3. Studies on the Effect of Chloroquine on the Secretory Function of the Digestive System in Rabbits kn-title=キノリン誘導体クロロキンの消化器系機能に及ぼす影響に関する研究 第3編家兎消化管分泌に及ぼす作用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Effects of chloroquine on gastric and bile secretion in rabbits were studied by intravenous injection of the drug. Furthermore the excretion rate of the drug into gastric juice and bile was determined. 1) Using the continuous collection technique, the basal secretory rate of gastric juice was found to decrease gradually with the lapse of time. However doses of 5 and 10 mg/kg of chloroquine, when injected intravenously, showed down the basal secretory rate. 2) On the other hand, these doses of the drug caused an elevation of gastric free acidity, and this stimulant effect on the acid secretion was more notable in the dose of 10 mg/kg, lasting for 3 hours after the intravenous injection. 3) Following intravenous injection of 10 mg/kg of chloroquine the drug was found to be excreted into gastric juice, yielding the concentration of 32.4〜81.0γ/l after 20 minutes and reaching the maximum of 659.8〜792.0γ/l after 3 hours. This concentration tended decrease after 4 hours. 4) Intravenous injection of chloroquine showed no effect on bile secretion by the same continuous collection technique. 5) The dose of 10 mg/kg of the drug was injected intravenously and it was shown that the drug was excreted also into bile. The concentration curves rose rapidly to the maximum of 531.1γ/l 1 hour after the injection and slowly returned to the level of about 40% of the maximum after 4 hours. 6) These results show chloroquine has a stimulant action on gastric secretion, particularly on gastric acid secretion, but has no significant effect on bile secretion in the doses administered. en-copyright= kn-copyright= en-aut-name=NagahiroSatoshi en-aut-sei=Nagahiro en-aut-mei=Satoshi kn-aut-name=永広哲 kn-aut-sei=永広 kn-aut-mei=哲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=569 end-page=586 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effect of Chloroquine, a Derivative of Quinoline, on the Function of the Digestive System. Part. 2.Studies on the Effect of Chloroquine on the Intestinal Motility in Rabbits. kn-title=キノリン誘導体クロロキンの消化器系機能に及ぼす影響に関する研究 第2編 家兎腸管運動に及ぼす作用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NagahiroSatoshi en-aut-sei=Nagahiro en-aut-mei=Satoshi kn-aut-name=永広哲 kn-aut-sei=永広 kn-aut-mei=哲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=557 end-page=567 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the Effect of Chloroquine, a Derivative of Quinoline, on the Function of the Digestive System. Part. 1 Studies on the Effect of Chloroquine on the Gastric Motility in Rabbits kn-title=キノリン誘導体クロロキンの消化器系機能に及ぼす影響に関する研究 第1編 家兎胃運動に及ぼす作用に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Effect of chloroquine on the motor activity of rabbit stomach were studied with or without combination of ATP-2Na by the balloon technique. 1) Four different doses of chloroquine 1, 3, 5 and 10 mg/kg were injected intravenously. At the doses of 1 and 3mg/kg the drug showed no effect on the gastric motility while at the doses of 5 and 10 mg/kg it showed a marked inhibitory action on the motility and tonus lasting for 4〜8 minutes. 2) ATP-2Na was administrated also intravenously in the doses of 3.1 and 6.2 mg/kg. At both doses the drug stimulated the gastric motor activity and tonus after a transient inhibition lasting for an average of 10 minutes. 3) When the motor activity of the stomach was accelerated by ATP-2Na, the addition of chloroquine showed either no effect or proved to be less inhibitory than when the latter was apllied alone. 4) Thus it is clear that chloroquine inhibits the gastric motility in rabbits and that ATP-2Na is antagonistic against chloroquine in this respect. en-copyright= kn-copyright= en-aut-name=NagahiroSatoshi en-aut-sei=Nagahiro en-aut-mei=Satoshi kn-aut-name=永広哲 kn-aut-sei=永広 kn-aut-mei=哲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第2内科 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=541 end-page=548 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Clinical and Statistical Studies on the Changes of the Clinical Pictures of Leukemia Part 1. On the Changes of the Clinical Pictures of Acute Leukemia in the Initial Stage kn-title=白血病病像の変貌に関する臨床統計的研究 第1編 急性白血病初期像の変貌について en-subtitle= kn-subtitle= en-abstract= kn-abstract=On 237 cases of acute leukemia admitted to our clinic from 1953 to 1965, the main symptoms and hematological findings in the initial stage were statistically evaluated. The observation time was devided into 3 periods; I (1953〜1957), II (1958〜1961) and III (1962〜1965). 1) Peripheral blood picture: Severe cases with hemoglobin below 40% (Sahli) were 57.0% during the Ist period and were 28.2% during the IIIrd period. On the other hand mild cases with hemoglobin above 70% were 9.2% during the Ist period and increased to 17.2% during the IIIrd period. Similar tendency was observed on red blood cell count (R. B. C.). Severe cases with R. B. C. below 2×10(6) were found in 66.2% during the Ist period and decreased to 31.0% during the IIIrd period. Mild cases with white blood cell count below 1×10(4) were found in 33.9% during the Ist period and increased to 40.7% in the IIIrd period. Mild cases with leukemic blasts below 10% showed an increase from 22.6% in the Ist period up to 34.9% in the IIIrd period. Mild cases with thrombocytes above 1×10(5) increased from 13.1% in the Ist period up to 17.6% in the IIIrd period. 2) Myelogram: Mild cases with leukemic blasts below 20% increased from 33.9% in the Ist period up to 38.0% in the IIIrd period. Severe cases with erythroblastic cells below 5% gradually decreased from 75.4% in the Ist period up to 64.9% in the IIIrd period. Mild cases in which we maintained erythroblastic cells above 15% increased from 8.8% inthe Ist period up to 22.1%in the IIIrd period. 3) Clinical symptoms: Mild cases without hemorrhagic diathesis increased from 29.2% in the Ist period up to 42.0% in the IIIrd period. While severe cases with remarkable hemorrhagic diathesis gradually decreased from 34.6% in the Ist period up to 19.6% in the IIIrd period. Cases with hepatomegaly of more than 2 finger breath showed a slight decrease from 27.4% in the Ist period up to 20.5% in the IIIrd period. No conclusive tendency was observed on splenomegaly. Cases without palpable lymphnodes were increased from 35.0% in the Ist period to 41.7% in the IIIrd period, while cases with remarkable lymphadenopathy decreased from 18.3% in the Ist period to 13.1% in the IIIrd period. Cases with high grade fever decreased from 29.0% in the Ist period up to 13.3% in the IIIrd period. From these results the author confirmed that relatively mild cases of acute leukemia on admission have gradually increased recently. In addition the tendency of decrease of monocytic leukemia and increase of acute lymphocytic leukemia was observed. en-copyright= kn-copyright= en-aut-name=IshizakiMasanobu en-aut-sei=Ishizaki en-aut-mei=Masanobu kn-aut-name=石崎雅信 kn-aut-sei=石崎 kn-aut-mei=雅信 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部平木内科教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=527 end-page=539 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Re-Appraisal on the Rate of Parasite Carriers Estimating the Rate of Parasite Carriers in Community by using the Results of Mass Examination of Feces in the Fields of School Health Practice kn-title=寄生虫保卵率の再検討 学童保卵率と地域住民保卵率との相関 en-subtitle= kn-subtitle= en-abstract= kn-abstract=There is a great need for prevention against parasitosis in the field of community health, though in actual practice, the mass examination for parasite carriers has not succeeded to get enough rate of receiving the examination. Because of this problem the author has investigated the conditions the performance of health practice against parasitosis, systematically. In order to get some criteria for the evaluation of the parasite control in communities, the author has investigated statistically the results of parasitic egg examination among general residents comparing to those of the school children at the same communities on O-prefecture. The objects were selected among the areas in this prefecture officially designed for "the promotion of preventive practice against ancylostomiasis". The studies have been carried out statistically and the results checked by the field surveys to learn the social factors influencing the receiving rate of examination and the efficiency of the practice. The results of the studies have been as follows: 1) By examining annual change of correlation between the rates of general residents and those of the school children in the same communities, there have been observed differences among the kinds of parasites. 2) Concerning "the special areas for preventive practice against ancylostomiasis" the parasite carries among the children has showed high correlation with those among general residents at the beginning of the designation as the special areas. This correlation has changed as the preventive practice proceeded. About ascariasis and other parasitoses, the correlation between the children and general residents have maintained relatively unchanged in high value. The differences of the elapse between the numbers of ancylostomiasis and the others could be derived from the ecological specialities and the mode of infection. 3) Correlation between the residents and children was high in ancylostomiasis when the receiving rate was over 80% and the same could be said in ascariasis when it was over 60%. 4) Also high correlation were observed between 1 to 3% of ancylostomiasis among school children, and under 15% of ascariasis among them. 5) These statistical results have been investigated expecting to get some criteria for evaluation of preventive practice. 6) The results of field survey about factors influencing on these data have been described. en-copyright= kn-copyright= en-aut-name=KatoShyoji en-aut-sei=Kato en-aut-mei=Shyoji kn-aut-name=加藤尚司 kn-aut-sei=加藤 kn-aut-mei=尚司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=509 end-page=526 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Study on 17-Ketosteroids in Umbillical Cord Blood kn-title=臍帯血中17-KS分画に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In recent years, new theory concerned upon the estriol biosynthesis in the pregnant was　developed remarkably. Diczfalusy and others demonstrated that DHA from foetal adrenal was the main precurssor of estriol in the pregnant.　Their approaches for this problem were tried mainly with in vitro incubation and circulation studies. In this study, the approach was tried with the determination of steroids in cord blood, maternalblood, maternal urine and urine of newborn. Androstanedion, Δ4-androstenedione, DHA, androsterone and etiocholanolone in cord blood were deter minated by new method, which was cosisted of following procedure. 1) 3s Hydrolysis (free steroid extraction, hydrolysis with β-glucuronidase in phosphatete buffer and transesterification with methyl-green and acetic acid. 2) Florisil column chromatography. 3) Thin layer chromatography. 4) Colorimetry following Lieberman, colour development with modified zimmerman reaction. The results of this determination were as following. In two cases, five androgens in cord blood and maternal peripheral blood, eight fractions of estrogens and nine fractions of 17-Ketosteroids in maternal urine, were determined. Also nine fractions of 17-Ketosteroids and four fractions of estrogens were determined in pooled urine of newborn. The results of these determination were as followings. 1) DHA level in cord blood was higher than that in maternal blood. But DHA level in maternal blood was cosiderably high. DHA in cord blood: 88.4μg/100ml, DHA in maternal blood: 37.3μg/100 ml It should be indicated that, thinking of maternal blood volume, maternal DHA is important for estriol biosynthesis. 2) Although DHA level in maternal urine was high, but DHA level in urine of newborn was low. Urinary DHA in mother: 1111.3μg/day, Urinary DHA in newborn: 10.050.0μg/day By this results, it is difficult to think that all estriol should be the product of foetal DHA. 3) Urinary estriol in early post-natal days was relatively high and then decreased to 10 and less μg in seven days of newborn. This indicates that the stored estriol was excreted in post-natal days. By these results, it should be clear that estriol biosynthesis is done not only in foetoplacentar unit, but also in maternalplacentar unit. It is claimed that steroids metabolism in pregnancy, as was seen in estriol biosynthesis, must be examined not as foeto-placentar unit but as foeto-placentar-maternal relation. en-copyright= kn-copyright= en-aut-name=KamadaShohei en-aut-sei=Kamada en-aut-mei=Shohei kn-aut-name=鎌田昌平 kn-aut-sei=鎌田 kn-aut-mei=昌平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部産婦人科教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=497 end-page=508 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Abnormality of Glucose Tolerance in Subjects with Liver Cirrhosis Part 2. Studies on Tolbutamide Test in the Patients with Liver Cirrhosis kn-title=肝硬変時の耐糖能異常に関する研究 第2編 肝硬変患者におけるTolbutamide負荷試験 en-subtitle= kn-subtitle= en-abstract= kn-abstract=80 subjects with liver cirrhosis selected for this study were divided into 2 groups, 24 cases were considered to have combinated with primary diabetes and the remaining 56 cases were not. The latter was classified into groups of probable diabetics, chemical diabetics, clinical diabetics, and non-diabetics according to the diagnosis from GTT. The results of tolbutamide test obtained were compared not only with each group with and without primary diabetes, but also with pathologic stage of the liver. The results were as tfollow: 1. Of 56 cases of liver cirrhosis wihout primary diabetes, 12 cases (21.5% ) revealed the diabetic curve in the tolbutamide test, and remaining 33 cases (58.9% ) were normal, on the other hand, of 24 cases combinated with primary diabetes, 21 cases (87.5% ), 3 cases (12.5% ), and no cases, respectively. 2. Observing the incidence of the abnormality of TTT in the subjects with liver cirrhosis from the view of the diagnosis of GTT, 11.8% of 18 cases with non-diabetic GTT, 47.0% of 17 cases with probable GTT, 61.9% of 21 cases with diabetic GTT, showed no abnormality, while, 24 cases combinated with primary diabetes were all found to be abnormal. Although the incidences described were high by about 10% than that found in each group of primary diabetics without liver cirrhosis, the frequency of the cases with delayed recovery in each group of liver cirrhosis was high by about 10% than those of primary diabetics. 3. Although the mean blood glucose curve following tolbutamide infusion in the subjects with liver cirrhosis without combination of primary diabetes situated between those of normal controls and of clinical diabetics, however, no significant difference could be observed in the mean blood glucose curve comparing the groups of liver cirrhosis with non-diabetic, probable, chemical diabetic GTT, and of combination with primary diabetes with those without liver cirrhosis. 4. Not only initial fall and subsequent rise in the blood glucose level, but also the duration requiring for reaching the minimum value following tolbutamide infusion were similarly delayed in both subjects with liver cirrhosis and primary diabetics without liver cirrhosis, and these delays became greater proportional to the grade of the impairment of their GTT. 5. It was impossible to find any significant correlation between the results of TTT and the duration of liver disease, the results of liver function test, or the histological changes in the liver, however, the frequency of impairment of TTT was greater in the subjects with ascites as compaired to that without it. 6. The incidence of abnormality of tolbutamide test (TTT) in the subjects with impaired prednisolone-primed glucose tolerance was significantly greater than that of the cases without impairment of the test.7. No significant correlation was observed between the results of TTT and of secretin test. 8. The response of immunoreactive insulin following tolbutamide infusion in the subjects with liver cirrhosis was higher than those of diabetics or normal subjects. 9. It was concluded from these results that the abnormal glucose tolerance found in the subjects with liver cirrhosis could not be distinguished by using the TTT from that derived from pancreatic factors. en-copyright= kn-copyright= en-aut-name=KusumotoToru en-aut-sei=Kusumoto en-aut-mei=Toru kn-aut-name=楠本亨 kn-aut-sei=楠本 kn-aut-mei=亨 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END start-ver=1.4 cd-journal=joma no-vol=80 cd-vols= no-issue=5-6 article-no= start-page=485 end-page=496 dt-received= dt-revised= dt-accepted= dt-pub-year=1968 dt-pub=19680630 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on Abnormality of Glucose Tolerance in Subjects with Liver Cirrhosis Part 1. Olinical Cbservation kn-title=肝硬変時の耐糖能異常に関する研究 第1編 臨床的観察 en-subtitle= kn-subtitle= en-abstract= kn-abstract=161 cases of liver cirrhosis were selected for studying the correlation between their abnormality of glucose tolerance and the pathologic stage or clinical course of them. The cases were divided into two groups; a group of 42 cases were clinically considered to have combinated with primary diabetes and the remaining 119 cases were not. Besides, the latter were classified more small groups according to the results of GTT. These groups of cases with liver cirrhosis were compared with the groups of probable diabetics, chemical diabetics and the clinical diabetics without liver disease upon some clinical features or the results of examination, and the results were as follows: 1. Of 119 cases of liver cirrhosis without primary diabetes 51 cases (42.9%) showed diabetic pattern in GTT, 36 cases (30.2%) probable diabetic, 7 cases (5.9%) oxyhyperglycemic, and 25 cases (21.0%) non-diabetic. 2. No incidence was found in the time of development or age distribution between the cases of liver cirrhosis with diabetic glucose tolerance and that combinated with primary diabetes or diabetic without liver disease. 3. Incidence of the abnormal glucose tolerance in the cases with liver cirrhosis did not correlate with the duration of the disease. 4. The abnormality of GTT showed high incidence in accordance with severity of liver injury in both of liver cirrhosis and hepatitis, however, it was impossible to find any significant correlation between the grade of abnormal glucose tolerance and the data of liver function test or the histological changes of the liver. 5. The glucose tolerance was not always aggravated inspite of progression from hepatitis to liver cirrhosis. The shift of the GTT and that of liver function disturbance were not always correlate with each other in both liver cirrhosis with abnormal glucose tolerance and that combinated with primary diabetes. 6. The grade or incidence of variou abnormalities from such points of view was high in accordance with the grade of abnormal glucose tolerance in cases with liver cirrhosis and no significant difference was seen as compared to the primary diabetics that the cases showing more than 100mg/dl of maximum fasting blood sugar in its duration, the cases with glycosuria before administration, or during GTT, occurance of the cases excreting more than 5 grams of glucose in whole day urine, influence of treatment with glucocorticoids, vacuolated nuclei occured in the liver cells, or development of complications related to the primary diabetes. It revealed that the stronger the abnormality of GTT in liver cirrhosis was, the more diabetic results. 7. The rate of abnormality of the results of prednisolonefrimed GTT was found to be higher in the cases of liver cirrhosis as compared to that of diabetes alone. 8. The incidence of occurence of vacuolated nuclei on the liver cells and of having complications related to primary diabetes was not different in the cases of liver cirrhosis with abnormal glucose tolerance or combinated with primary diabetes from that of chemical diabetes or clinical diabetes. 9. It might be possible to conclude from these results that the characteristics of abnormal glucose tolerance found in liver cirrhosis is similar to that found in primary diabetes and that the cases of liver cirrhosis with abnormal glucose tolerance might include primary diabetes or pancreas injury. en-copyright= kn-copyright= en-aut-name=KusumotoToru en-aut-sei=Kusumoto en-aut-mei=Toru kn-aut-name=楠本亨 kn-aut-sei=楠本 kn-aut-mei=亨 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一内科教室 END