岡山医学会 Acta Medica Okayama 0030-1558 76 11-12 1964 正中神経および尺骨神経損傷の予後に対する臨床的研究 781 799 EN Sadao Kawahara By direct examinations of 46 patients with 55 injured nerves out of those patients who had received the suture of injured median and ulnar nerves in the past 7 years at Department of Orthoedic Surgery, Okayama University and of those over one year after the operation, postoperative results were studied and the following findings were obtained. 1. As the lapse of time after inception of the nerve injnry passes 3 months, the postoperative result gradually grows poorer and after 6 months the prognosis is extremely poor. In contrast, the secondary suture performed as early as 3 to 8 weeks after the injury gives satisfactory results and it does not necessarily require primary suture. 2. The younger the patient, the better is the prognosis, especially the prognosis is very good in the age range of 0 to 9 years old. 3. It has been found that prognosis is relatively good in the cases of sharp cut injuries such as glass cut injury because the damage to nerves as well as to surrounding tissues is smaller and the danger of infection is less. 4. In the cases who had infection of some kind prior to receiving the nerve injury the postoperative results are invariably poor. 5. when the injury is sustained at a level more proximal, the results are poorer. Ulnar nerves are injured more frequently at high and intermediate levels. This point also explains the poor postoperative results in the cases of ulnar nerve injuries. 6. There is a possibility of recovery for the period of 5 years after the nerve suture, and especially the recovery of sensory function can be expected for 5 year period after the suture operation. 7. In the ease where median and ulnar nerves are injured simutaneously on the same level, these two nerves recover to about the same degree. 8. By means of two test, namely, picking up test and precision grip test, it has been possible to examine the effect on the routine affairs of life of the patient, that was ditficult to accomplisd by the former sensory tests. 9. The sudomotor function after suture of injured nerve does not necessarily parallel with the recovery of sense, and in the cases past 3 years after suture the sudomotor function in practically every case has recovered to normal irrespective of the sensory function. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 76 11-12 1964 胸部間接撮影による心臓計測値の推移に関する研究 第2編 血圧及び体格の影響について 775 780 EN Tatsuaki Morishita 1. The measured values in various parts of the heart in fluorograms, examining how they change in ten years, was calculated. Its result showed the difference of the increse caused by body-weight was hardly noticed. 2. Concerning the relation between body-weight and the measured value of heart; in the group of fat people, the left aortic arch diameters and the transverse diameters right and left showed a considerable greater value than in those of average and thin people. 3. with recept to the transition of blood pressure and cardiac measurements over ten years, the high blood pressure group showed a notable increase in the aortic arch diameters right and left and the left transverse diamters against the normal blood pressre group. 4. As to relation between blood pressure and cardiac measurements, the high blood pressure group showed high value in the left transverse diameters and the aortic arch diameters right and left, in comparison with the normal blood pressure group. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 76 11-12 1964 胸部間接撮影による心臓計測値の推移に関する研究 第1編 血圧及び年令の影響について 769 774 EN Tatsuaki Morishita 1. On measuring the values in various parts of the heart in fluorograms, it was examined how they change in ten years. The result of the examination showed that the aortic arch diameters right and left, the transverse diameters on the left increased in proportion to the increase of man's age. The rate of increase, however, was not the same in age; generally, the older a man is, the greater the percentage of increase will be; the left transverse diameters showed the greatest rate of swell in the age from twenties to thirties. 2. About the relation between age and cardiac measurements, every measured value, except the right transvers diameters, was proved to be greater in the older age. The right transverse diameters registered its highest value in the age from thirties to forties without reference to blood pressnre. 3. In regard to the transition of blood pressure and cardiac measurements over ten years; the notable increase in the aortic arch diameters and the left transverse diameters of high blood pressure group was perceived, as compared with the normel blood pressure group. In the left aortic arch diameters and the left transverse diameters, the high blood pressure group showed twice as much rate of increase as the normal blood pressure group. 4. About the relation between blood pressure and cardiac measurements, the high blood pressure group showed greater value than the normal blood pressure group in the left transverse diameters and the aortic arch diameters right and left. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 76 11-12 1964 脳神経細胞の機能とリボ核酸との関係に就いて 第2編 廿日ネズミの脳RNAと脳運動機能の関連に就いて 711 719 EN Hisao Hamada In a previous paper it was revealed that either the injection of RNase directly into the cerebral tissue or into liquor by cisternal puucture caused similar changes on tbe reduction of RNA level of the cerebral ganglion cells in the brain of guinea pigs, and the behavioral changes of the animals. It was thought that the same method might also be applicable to the mouse in which further paychological and behavioral analysis are more readily accomplished. In the present experiment RNase was injected directly into cerebral tissue of the mouse and the motor function of the mouse brain was analyzed. As the result it was found that on the injection of 0.05ml of 1% RNase directly into the cerebral tissue of the mouse, severe motor disturbance was induced, and in addition, the degree of the functional disturbance paralleled with the decreased leve of RNA on the cerebral ganglion cells. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 76 11-12 1964 脳神経細胞の機能とリボ核酸との関係に就いて 第1編 海猽の脳に対するリボ核酸分解酵素の生物学的作用に就いて 703 710 EN Hisao Hamada It is well recognized that those cells, requiring protein synthesis as growing immature cells or the secretory gland cells, contain a large amount of RNA in their cytoplasm, thus ribonucleic acid in the cytoplasm plays a very important role in the protein synthesis. Altho ugh cerebral ganglion cells contain a fairly large amount of RNA in their cytoplasm, the cell growth, cell division and protein secretion are not usually observed in these particular cells. High level of RNA of the cerebral ganglion cells may have an intimate relation with the highly differentiated cell function of the cerebral ganglion. For the purpose to elucidate the high level of RNA in the cerebral ganglion cells and its function, the author injected ribonuclease into the brain and liquor of guinea pigs to decompose RNA in the brain tissue. The behaviors of the animal under these conditions were observed, and also histological examinations were performed with each animal. As the result the following points were clarified. 1) when over 1 mg of RNase was injected into the brain, it caused lytic change of RNA in the cerebral ganglion cells and functional disturbances such as immobility, but the animal still retained the orientation ability. 2) It was confirmed that neither reduction nor disappearance of RNA in the cerebral ganglion cells could be the real cause of the experimental guinea pigs. These results suggest that this method would serve adequately for the analysis of the role of RNA in the brain cells. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 76 11-12 1964 手術前後の心電図 697 702 EN Shoichi Haraoka Chikara Hayashi Michihiko Sato Yoshihiro Hatano Hiroshi Shiina Akira Tanaka ECGs were examined in 88 cases before and after operation. After operation, ECG was taken on the second, fourth and sixth day. Fourty-two cases (48%) showed some changes in ECG after operation. Patients with gastric cancer showed some changes most frequently (63%). Among the post operative changes, T wave change was more common. Hypertension, bleeding, variation of blood pressure during operation and operation time had influence on the ECG. Serum potassium was prove to be lowered after operaiion. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 76 11-12 1964 白血病の細胞学的分類 689 696 EN Hiroshi Sanada Zensuke Ota Takashi Kotsuka Osamu Onoye Yoshinobu Sakikawa Tatsuro Saihara Kazunori Honke In the attempts to classify leukemic cells it is often difficult to identify cells solely with fixed and stained blood smears as in acute leukemia where the percentage of blast cells is high. In such instances, however, it is generally possible to distinguish most cells when vital observations are carried out in conjunction with cytochemical methods, fluorescence micro scopy, as well as electronmicroscopy. The results of these observations have been briefly summarized. The characteristic findings of lymphoblasts, myeloblasts, and monoblasts as revealed by May-Giemsa staining, brilliant cresyl blue supravital staining, phase-contrast microscopy, vital staining and electronmicroscopy. are illustrated in the tables. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 76 11-12 1964 血液疾患における鉄吸収に関する研究 第3編 血液疾患々者腸粘膜の鉄吸収能 679 687 EN Junichiro Tsuchida In normal controls, essential hypochromic anemia and aplastic anemia, biopsies of the duodenal mucosa were performed for an investigation of the amount of stainable iron and iron uptake by means of radioautography. Followings are the conclusions derived from comparison of these two values. 1. The uptake of radioactive iron into the intestinal epithelium is mild in normal controls and remarkable in essential hypochromic anemia, although no differences were noted following iron treatment. Almost no iron was taken up in aplastic anemia. 2. In general, the amount of non-hemine iron in the intestinal mucosa is invertly proportional to iron absorption rate of the intestinal epithelium. This indicates that the intestinal iron absorption is influenced by the amount of intestinal tissue iron, and the intestinal epithelium, bordering the intestinal cannal, plays an important role in the initial stage of the iron absorption. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 76 11-12 1964 血液疾患における鉄吸収に関する研究 第1編 血液疾患々者の腸粘膜生検による病理組織学的観察 655 663 EN Junichiro Tsuchida In normal controls and patients with various blood diseases, biopsies of the duodenal mucosa were performed for an investigation of histopathological changes and their relation to intestinal iron absorption. Followings are the results. 1. In essential hypochromic anemia, leukemia, and anemia associated with cancer, inflammatory changes were observed, and in a case of acute myelogenous leukemia, infiltration of immature myelogenous cells was observed. 2. Little inflammatory changes were noted in aplastic anemia, suggesting that histological changes in the intestinal mucosa are not related at least to the genesis of this disease. 3. In a case of hookwarm anemia, remarkable inflammatory changes were noted, suggesting the presence of disturbances in the intestinal iron absorption as one of the causes of this anemia. 4. No significant histological changes were observed in myxedema, Mikulicz syndrome, purpura simplex, and pernicious anemia. 5. The above investigations suggest that inflammatory changes of the intestinal mucosa generally have some influences on the iron absorption. No potential conflict of interest relevant to this article was reported.

岡山医学会 Acta Medica Okayama 0030-1558 76 11-12 1964 犬腎培養細胞による麻疹ウイルスの研究 第2編 麻疹ウイルスに対する犬腎細胞と各種培養細胞との感受性及び病理形態学的変化の比較 647 654 EN Takeo Utsumi A comparative study on the susceptibility of measles virus and pathological changes of cells in culture was carried out with dog kidney cells and many other cultured cells by inoculating measles virus into the media of cultures. As the result it was found that FL cells and HeLa cells demonstrated the highest infectivity, followed by that of dog kidney cells. Monkey cells (MS cells) and human amnion cells (JJC-3 cells) also showed a fair degree of infectivity to measles virus (the report on such cells has not yet been made public). On the other hand, L cells and hamster kidney cells, what had been generally reported to be readily infected by measles virus were found to show a low infectivity only, indicating them to be not suitable cells for such a study. In the case of dog kidney cells infected with measles virus, viral proliferation could be observed clearly during the period 4 to 7 days after the inoculation. No potential conflict of interest relevant to this article was reported.