start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=995
end-page=998
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Hemolytic, Anemia-Inducing Substance in Cancer Tissue
kn-title=癌組織中の溶血性細胞毒に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In 1959 we discovered that a hemolytic, anemia-inducing substance is produced in the animals exposed to X-rays. Since then we have found that when this substnce is injeted intravenously into animals, there occur disturbances in the blood, spleen and bone marrow. And also it has become clear that this substance brings about Heinz's body appearance in erythrocytes. As Heinz's body also appears in cancer anemia and it is transformed into hemolysin, it may be assumed that the hemolytic, anemia-inducing substance is contained also in cancer tissue. Upon such assumption we have compared the hemolytic capacity of the extract obtained from the fresh gastric cancer tissue resscted at operation with that of the extract from normal gastric tissue. As the result, we have recognized that this hemolytic, anemia-inducing substance is contained considerably in cancer tissue.
en-copyright=
kn-copyright=

en-aut-name=YamamotoMichio
en-aut-sei=Yamamoto
en-aut-mei=Michio
kn-aut-name=山本道夫
kn-aut-sei=山本
kn-aut-mei=道夫
aut-affil-num=1
ORCID=

en-aut-name=NobukiSigeo
en-aut-sei=Nobuki
en-aut-mei=Sigeo
kn-aut-name=信木茂生
kn-aut-sei=信木
kn-aut-mei=茂生
aut-affil-num=2
ORCID=

en-aut-name=SiakuTakeru
en-aut-sei=Siaku
en-aut-mei=Takeru
kn-aut-name=塩飽健
kn-aut-sei=塩飽
kn-aut-mei=健
aut-affil-num=3
ORCID=

en-aut-name=AkagiKeiko
en-aut-sei=Akagi
en-aut-mei=Keiko
kn-aut-name=赤木瑩子
kn-aut-sei=赤木
kn-aut-mei=瑩子
aut-affil-num=4
ORCID=

en-aut-name=SiakuMidori
en-aut-sei=Siaku
en-aut-mei=Midori
kn-aut-name=塩飽緑
kn-aut-sei=塩飽
kn-aut-mei=緑
aut-affil-num=5
ORCID=

en-aut-name=IgutiYosiko
en-aut-sei=Iguti
en-aut-mei=Yosiko
kn-aut-name=井口与志子
kn-aut-sei=井口
kn-aut-mei=与志子
aut-affil-num=6
ORCID=

en-aut-name=TanimotoJunichi
en-aut-sei=Tanimoto
en-aut-mei=Junichi
kn-aut-name=谷本潤一
kn-aut-sei=谷本
kn-aut-mei=潤一
aut-affil-num=7
ORCID=

en-aut-name=KojimaSumikazu
en-aut-sei=Kojima
en-aut-mei=Sumikazu
kn-aut-name=小島澄一
kn-aut-sei=小島
kn-aut-mei=澄一
aut-affil-num=8
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部放射線医学教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部放射線医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=959
end-page=993
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The Effect of Respiratory Enzyme Inhibitors on Infection of Rickettsia
kn-title=各種呼吸酵素阻害剤のRickettsiaの感染に及ぼす影響
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Using several kinds of respiratory enzyme inhibitors, the author studied the effect of the inhibitors on infection of rickettsia to mouse. The investigations were carried out in vitro and in vivo and the observations were made from day to day. Moreover, the characters of rickettsia were investigated by the re-inoculation to normal mouse from the culture. The following results were obtained. 1) The infection of rickettsia were found to be suppressed by previous in vitro treatment of rickettsia with any enzyme inhibitors tested, but the suppression effect was varied by hind of inhibitors, its concentration, duration of its action and the concentration of rickettsial suspension. The infection capacity of enzyme inhibitor treated-rickettsia showed a decrease in cases of 5 hours treatment of 10-20 mg malonate, of 1.0 mg monojodo acetic acid or of 1.0 mg fluoride. However, the affection of these inhibitors was vary specific, and found to have caused merely a reduction of infection capacity or a suppression of infection instead of to caused an inactivation of rickettsia. 2) On the contrary the inhibitors did not show an inhibitory effect to the infection of the rickettsia, if the inhibitors were administrated to the mouse to be tested before the attack of rickettsia. Accordingly a fairly difinite infection and the successive multiplication of rickettsia were observed on the previousely inhibitor-treated mouse; upon rare occasions the infection was found to be severe on these treated mouse. 3) The effect of inhibitors also studied by obeorving properties of re-inoculated rickettsia to normal mouse, the rickettsia was taken from the culture on the previously inhibitor-treated mouse. The multiplication of re-inoculated rickettsia was measured by means of LD(50) curve, and was demonstrated that the appearance of symptomes and the days to death after the infection was somewhat delayed on the treated animal compared to the control; but the occurences were almost in the same way as in the control except a short delay of the time. Hence, the affected metabolism of host cell and metabolic system of animal required to multiplication of the rickettsia were supposed to show so much definite effect to the suppression of infection.
en-copyright=
kn-copyright=

en-aut-name=KiyotoMasahiro
en-aut-sei=Kiyoto
en-aut-mei=Masahiro
kn-aut-name=清遠正博
kn-aut-sei=清遠
kn-aut-mei=正博
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=951
end-page=958
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Influences of OX (unsaturated fatty acidextract) on Ehrlich's Ascites Tumor cells
kn-title=工ールリッヒ癌に及ぼすOXの影響に就いて
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In view of the fact that there may be two possible actions in radiation distrurbaces in vivo, namely, one acting directly and the other acting indirectly, and on the assumption that these actions, persisting quite a long time after irradiation, induce specific substance in the irradiated nimals, Yamamoto of our department, has succeeded in isolating unsaturated fatty acid substance (OX) specific to the irradiated animals. With the purposa to find out what influences this substance (OX) will have on Ehrlich's ascites tumor cell, the author studied its effect on the number, mitotic phases and DNA ontents of the cancer cells. Test animals used are 80 mice each wighing about 15-20g. To these animals 0.2cc cell suspension of Ehrlich's ascites tumor cell is transplanted intraperitoneally and one week after the transplantation 0.2cc of 2%-, 1%-, 0.5%- OX substance is injected intrapeitoneally to these animals. By observing the changes in the cell counts, mitotic phase, and the DNA contents in each cell (with spectrophotometry) at the intervals of 1, 3, 6, 9, 12, and 24 hours after the injection of OX substance, and the following results were obtained: The number of cancer cells has been found markedly decreased; nomely, after one hour it is down to 78 per cent of the original count; down to 44per cent after 9 hours; and clown to 46.2 per cent after 24 hours. As for the mitotic phases, metaphase, anaphase telophase have been increased and the number of cells undergoing mitosis is diminished. Moreover, as for the DNA contents per cell, there can be observed an increase ni the number of cells with a markedly small amount of DNA, while the cells undergoing duplication due to mitosis have been found decreased in number. From these facts it is concl ded that OX substance acts on Ehrlich's ascites tumor cells as to induce the following disturbances: (1) cell destruction, (2) impairment of the activity in mitotic apparatus, (3) disturbance of the DNA synthesis, and (4) elicits atypical cell divistion.
en-copyright=
kn-copyright=

en-aut-name=ItamiMotoya
en-aut-sei=Itami
en-aut-mei=Motoya
kn-aut-name=伊丹尤也
kn-aut-sei=伊丹
kn-aut-mei=尤也
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部放射線医学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=943
end-page=949
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A CLINICAL STUDY OF THE INTRAVENOUS THIAMYLAL SODIUM ANESTHESTA FROM THE STANDPOINT OF THE BLOOD AND INTERSTITIAL FLUID PART II THE RELATIONSHIP BETWEEN THE ANESTHESIA DURATION AFTER ADMINISTRATION OF THIAMYLAL SODIUM AND BLOOD AND INTERSTITAL FLUID
kn-title=体内水分電解質分布とThiamylal Sodium静脈麻酔との関係に関する臨床的研究 第2編 体内水分電解質のThiamylal Sodium静脈麻酔における麻酔時間に及ぼす影響について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Twenty-one patients were anesthetized by intravenous injection of thiamylal sodium and the relationships between the duration of anesthesia and the blood and interstitial fluid were studied. 1) A parallel correlation was seen between the anesthesia duration and the water content of plasma. 2) A reverse correlation was found between the sleeping time of anesthesia and quantity of the total plasma protein. 3) No interrelatiohships were found between the duration of anesthesia and hematerit, water content of blood, serum natrium, serum chloride, serum pottasium and plasma volume. 4) A reverse correlation was seen between the sleeping time of anesthesia and the interstitial fluid volume.
en-copyright=
kn-copyright=

en-aut-name=MatsudaSumizo
en-aut-sei=Matsuda
en-aut-mei=Sumizo
kn-aut-name=松田住蔵
kn-aut-sei=松田
kn-aut-mei=住蔵
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=933
end-page=942
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A CLINICAL STUDY OF THE INTRAVENOUS THIAMYLAL SODIUM ANESTHESIA FROM THE STANDPOINT OF THE BLOOD AND INTERSTITIAL FLUID PART I CHANGES IN BLOOD AND INTERSTITIAL FLUID BY INTRAVENOUS THIAMYLAL SODIUM ANESTHESIA
kn-title=体内水分電解質分布とThiamylal Sodium静脈麻酔との関係に関する臨床的研究 第1編 Thiamylal Sodium静脈麻酔前後における体内水分電解質分布の変動について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Twenty-one patients were anesthetized by intravenous injection of thiamylal sodium and changes in blood and interstitial fluid were observed before and after anesthesia. 1) The specific gravity of blood and plasma, plasma protein and hematcrit slightly increased after intravenous administration of thimylal sodium, while the water content of blood and pleasma decreased. 2) Among the plasma electrolytes, plasma nartrium and chloride decreased, while plasma pottasium increased. 3) A decrease of plasma volume and an increase of interstitial fluid were observed. 4) The changes of factors mentioned above is regarded to be caused not only by blood concentrasion but also by transmission of plasma fluid to extracellular fluid.
en-copyright=
kn-copyright=

en-aut-name=MatsudaSumizo
en-aut-sei=Matsuda
en-aut-mei=Sumizo
kn-aut-name=松田住蔵
kn-aut-sei=松田
kn-aut-mei=住蔵
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第1（陣内）外科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=927
end-page=931
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Comparative Study on the Effect of Aureomycin, Chloromycetin, and Streptomycin on the Bacterial Respiration
kn-title=微生物の呼吸に対するオーレオマイシン，クロロマイセチン及びストレプトマイシンの作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This experiment was performed to investigate the effect of aureomycin, chloromycetin, and streptomycin upon the oxidation of several substrates by Sh. flexneri 2a and E. coli communis. The results are as follows: 1) A level of 200γ/ml aureomycin markedly inhibits the oxygen uptake with substrates such as glucose, pyruvate, glutamate, and aspartate. The inhibitory rate has no relation to the preincubation time of a mixture of aureomycin and a cell suspension. 2) A high concentration (200γ/ml) of chloromycetin slightly inhibits the oxidation of amino acids such as glutamate and aspartate. The inhibitory rate has a relation to the preincubation time of a mixture of chloromycetin and whole cell suspensions. 3) A level of 200γ/ml streptomycin slightly inhibits the oxidation of glutamate and aspartate by E. coli, but it does not affect the oxidation of glucose and pyruvate by this organism. The oxidation of proposed substrates by Sh. flexneri 2a is not also prevented by streptomycin. Even though streptomycin is added to the original cell suspension before the substrates and preincubated for an hour, the results are the same.
en-copyright=
kn-copyright=

en-aut-name=KawaiKiyoshi
en-aut-sei=Kawai
en-aut-mei=Kiyoshi
kn-aut-name=川井潔
kn-aut-sei=川井
kn-aut-mei=潔
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoToyozi
en-aut-sei=Matsumoto
en-aut-mei=Toyozi
kn-aut-name=松本豊治
kn-aut-sei=松本
kn-aut-mei=豊治
aut-affil-num=2
ORCID=

en-aut-name=HonmatsuKakushi
en-aut-sei=Honmatsu
en-aut-mei=Kakushi
kn-aut-name=本松格史
kn-aut-sei=本松
kn-aut-mei=格史
aut-affil-num=3
ORCID=

en-aut-name=AkiyamaKengi
en-aut-sei=Akiyama
en-aut-mei=Kengi
kn-aut-name=秋山健二
kn-aut-sei=秋山
kn-aut-mei=健二
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=921
end-page=926
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Effect of Streptomycin on the Metabolic Activities of Bacteria
kn-title=微生物の代謝に対するストレプトマイシンの作用
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This experiment was attempted to investigate the inhibitory action of streptomycin. The organism used is Shigella flexneri 2a. The results are as follows: 1) Even under a level of 200γ/ml streptomycin, it cannot inhibit the oxidation of pyruvate, succinate, fumarate, malate, glutamate, and aspartate by whole cell suspensions. 2) When glutamate is added to a cell suspension that has previously been permitted to oxidize fumarate, an immediate increase in oxygen consumption is observed. This increase is scarcely prevented by streptomycin. 3) The oxidatin of a mixture of glucose, glutamate, and 10(-3)M Mg(++) by a cell suspension is prevented by streptomycin level of 200γ/ml. 4) Streoptomycin prevents especially aerobic growth of this organism in the synthetic medium and results in an increased accumulation of pyruvate as a metabolic product.
en-copyright=
kn-copyright=

en-aut-name=KawaiKiyoshi
en-aut-sei=Kawai
en-aut-mei=Kiyoshi
kn-aut-name=川井潔
kn-aut-sei=川井
kn-aut-mei=潔
aut-affil-num=1
ORCID=

en-aut-name=MatsumotoToyozi
en-aut-sei=Matsumoto
en-aut-mei=Toyozi
kn-aut-name=松本豊治
kn-aut-sei=松本
kn-aut-mei=豊治
aut-affil-num=2
ORCID=

en-aut-name=HonmatsuKakushi
en-aut-sei=Honmatsu
en-aut-mei=Kakushi
kn-aut-name=本松格史
kn-aut-sei=本松
kn-aut-mei=格史
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=915
end-page=919
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A Comparative Study on the Tryptophan Metabolism of Streptomycin-sensitive and Streptomycin-resistant Shigella flexneri
kn-title=赤痢菌のストレプトマイシン耐性変異とトリプトフアン代謝
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=There has been very little experimental work on the tryptophan metabolism of streptomycin-resistant bacteria. The authors performed this experiment in order to find out the differencies of the tryptophan metabolism between streptomycin-sensitive and streptmycin-resistant Shigella flexneri 2a. The results were as follows: 1. When streptomycin-resistant strains were grown in the streptomycin-containing medium, they have quantitatively lower tryptophanase activity than streptomycin-sensitive strains. 2. Streptomycin-resistant strains restores tryptophanase activity when streptomycin is absent in the growth medium, but they are resistant to streptomycin (10,000γ/ml). 3. Tryptophanase activity of both strains is inhibited slightly by divalent metal ions such as Mg, Fe, and Mn, but the inhibitive action of Cu is very remarkable. Natrium azide and arsenite have no effect. Vitamin B(6) and 2.4-dinitrophenol accerelates indole production from tryptophan by this organism. 4. Of the the various antibiotics aureomycin inhibits most markedly tryptophanase activity and chloromycetin does slightly, but streptomycin has no influence. 5. Tryptophanase is an adaptive enzyme, and considered to have essentially no relation to streptomycin-resistant mutation.
en-copyright=
kn-copyright=

en-aut-name=KawaiKiyoshi
en-aut-sei=Kawai
en-aut-mei=Kiyoshi
kn-aut-name=川井潔
kn-aut-sei=川井
kn-aut-mei=潔
aut-affil-num=1
ORCID=

en-aut-name=NishiiEmiko
en-aut-sei=Nishii
en-aut-mei=Emiko
kn-aut-name=西井笑美子
kn-aut-sei=西井
kn-aut-mei=笑美子
aut-affil-num=2
ORCID=

en-aut-name=TakahashiManabu
en-aut-sei=Takahashi
en-aut-mei=Manabu
kn-aut-name=高橋学
kn-aut-sei=高橋
kn-aut-mei=学
aut-affil-num=3
ORCID=

en-aut-name=HonmatuKakushi
en-aut-sei=Honmatu
en-aut-mei=Kakushi
kn-aut-name=本松格史
kn-aut-sei=本松
kn-aut-mei=格史
aut-affil-num=4
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部微生物学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=901
end-page=913
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Physiological Studies on the Metabolic Activities of Streptomycin-Resistant B. dysentheriae �U. The Pyruvate Metabolism and its Terminal Respiration System of Streptomycin-Resistant Sh. flexneri 2a
kn-title=ストレプトマイシン耐性赤痢菌の生理学的研究 第2編 ストレプトマイシン耐性赤痢菌駒込Ｂ�Vのピルビン酸代謝と終末呼吸系
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Following the previous reports, the author carried out the experiment to elucidate the difference in the pyruvate oxidation and its terminal respiration system between resistant and susceptible Sh. flexneri 2a. 1) The oxidation rate of pyruvate by resistant strain is considerably less at every pH than by susceptible strain. The pH optimum for oxidation of pyruvate of resistant strain is pH 5.6-6.0, whereas that of susceptible strain is pH 7.0-7.5. 2) The consumption rate on pyruvic acid substrate by resistant strain is significantly less than by susceptible strain. 3) Both resistant and susceptible strains oxidizes pyruvic acid via succinate. Pyruvate accumulates during the oxidation of the tricarboxylic acid cycle intermediates such as succinate, malate, fumarate, α-ketoglutarate by resistant and susceptible strains. 4) Aspartic-glutamic transamination has been demonstrated in susceptible strain under aerobic condition with both aspartic acid and glucose added. 5) The oxidation of pyruvate of susceptible strain can be accerelated more rapidly by divalent metal ions such as Mg??, Fe??, Mn?? than that of resistant strain. 6) Panthotenate accerelates more reasonably the respiration of pyruvie acid by susceptible strain than by resistant strain. 7) The significance of these results in relation to the presence of the citric acid cycle in the organism is discussed, and it is considered possible that an significant difference in metabolic activities between resistant and susceptible strains exists in the metabolic pathway from pyruvate to succinate in the citric acid cycle.
en-copyright=
kn-copyright=

en-aut-name=KawaiKiyoshi
en-aut-sei=Kawai
en-aut-mei=Kiyoshi
kn-aut-name=川井潔
kn-aut-sei=川井
kn-aut-mei=潔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=889
end-page=899
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Physiological Studies on the Metabolic Activities of Streptomycin-Resistant B. Dysentheriae. 1. The Carbohydrate Metabolism of Streptomycin-Resistant Sh. flexneri 2a
kn-title=ストレプトマイシン耐性赤痢菌の生理学的研究 第1編 ストレプトマイシン耐性赤痢菌駒込Ｂ�Vの糖代謝
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The resistance to streptomycin should be demonstrated by some differencies in metabolic reactions detectable by comparisons made between resistant and susceptible bacteria. This paper is concerned with the examination of the glucose metabolism of streptomycin-susceptible and streptomycin-resistant strains of Sh. flexneri 2a. The resistant strains was obtained by serial transfers in progressive levels of streptomycin. This resistant variant could withstand at least 10,000γ per ml of streptomycin. 1) The oxidative abilitys of the resistant strains is considerably less on pyruvate among the components of the citric acid cycle than is that of the susceptible strain. 2) Pyruvic acid, lactic acid, and acetic acid accumulates during the oxidation of glucose by resistant and susceptible strains. The amount of pyruvic acid produced from glucose by resistant strain is more than that by susceptible strain. In the rate of consumptions of glucose between resistant and susceptible strains there is much less difference. 3) No significant difference between both strains is detected in anaerobic metabolism of glucose. 4) Resistant strains which has grown on continued subculture by serial transfer in the medium not containing streptomycin possess still these properties. This culture was also found to be resistant to at least 10,000γ per ml of streptomycin. 5) It is suggested that streptomycin-resistant and susceptible strains dissimilates glucose mainly by way of Embden-Myerhof pathway, and also have Warbung-Dickens pathway as an alternate pathway. 6) Streptomycin-susceptible strain growes more rapidly than streptomycin-resistant strain in shaking culture. 7) These results suggests that streptomycin-resistant strain is more fermentative in the metabolism of glucose than streptomycin-susceptible strain, and a significant difference between streptomycin-resistant and streptomycin susceptible strains exists in pyruvate metabolism and its terminal respiration system.
en-copyright=
kn-copyright=

en-aut-name=KawaiKiyoshi
en-aut-sei=Kawai
en-aut-mei=Kiyoshi
kn-aut-name=川井潔
kn-aut-sei=川井
kn-aut-mei=潔
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部微生物学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=845
end-page=854
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Cytological Studies on the Aspirated Fluid with the Phase-Contrast Microscope Part 1. Cytological Studies on the Normal Ascites of Human and Various Animals
kn-title=位相差顕微鏡(PCM)観察による穿刺液の細胞学的研究 第1編 人並びに各種動物の正常腹水の細胞学的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Comparative studies were carried on the normal ascitic cells, especially on phagocytes that occupy the major portion of ascitic cells, aspirated from mammalians such as mice, rats, rabbits, dogs, cats, and human as well as from chicken by the pressure method with a phase contrast microscope and also with moving pictures of these various cells. As the results the following conclusions were arrived at: 1. The majority of mouse phagocytes have the characteristics similar to those of monocytes and histiocytes. 2. In the higher animals such as rats and rabbits a greater portion of them show flagellar pseudopodia and the aggregating tendency of highly reflactile granules and the distribution of mitochondria along the groove of the nucleus. And their nuclear membrane is thin and the nuclei are solid with a complicated shape, and the nuclear substance is soft but without any nucleoles. All of these findings become quite similar to those of monocytes, and in dogs and cats they can hardly be distinguished from monocytes. In the case of normal human phagocytes most of them show degeneration but even these cells reveal the characteristics very close to those of monocytes but far different from those of histiocytes. Even in the chicken phagocytes an unexpectedly large portion of them possess marked characteristics of monocytes. 3. As for the movement of these cells it is minimal, differing from blood monocytes this point, but it seems that this is due to the adaptation peculiar to the circumstances as ascites. From these findings it can be concluded that the ascitic cells possess characteristics far different from those of histiocytes but extremely similar to those of monocytes.
en-copyright=
kn-copyright=

en-aut-name=KamuraJunta
en-aut-sei=Kamura
en-aut-mei=Junta
kn-aut-name=嘉村淳太
kn-aut-sei=嘉村
kn-aut-mei=淳太
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部平木内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=831
end-page=844
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600130
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Sulfur Metabolism in Infants Part 2. The Sulfur Metabolism in Infants under Breast Feeding and in Infants under Artifical Feeding
kn-title=乳児の硫黄代謝に関する研究 第2編 天然及び人工栄養児の硫黄代謝
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=By the new method as described in Part I the author studied the sulfur and nitrogen metabolism in infants under breast feeding and in infants under artificial feeding, and obtained the following results. 1. In the infants under breast feeding at the age of 1-2 months, 3-4 months, and 5-6 months old the average sulfur retention at each period has bead 25.7, 33.7, and -0.53 per cent respectively. Similarly in the infants under artificial feeding at the same age range the average retenrion has beed 35.1, 48.6 and 40.4 per cent respectively. 2. In the case of the infants under breat feeding at the age of 5-6 months old the quantity of sulfur retained gives a negative value, but this seems to be due to an increased urinary excretion of sulfur in the process of the conversion of cartilage to bone. 3. The nitrogen retention rate shows no difference due to feeding methods. 4. Nitrogen-sulufr ratio (N/S) of the retention differs according to the method of feeding. Namely, the ratio N/S in infants under breast feeding is 25.2 while that in infants under artificial feeding is 18.8. 5. N/S values of the retention in infants under breast feeding are higher than those in infants under artificial feeding. This fact indicates that sulfur in breast milk is more effective than that in cow's milk for increasing the quantity of nitrogen to be retained, and this in turn seems to be due to the action of cystine-sulfur contained in breast milk.
en-copyright=
kn-copyright=

en-aut-name=HamadaGibun
en-aut-sei=Hamada
en-aut-mei=Gibun
kn-aut-name=濱田義文
kn-aut-sei=濱田
kn-aut-mei=義文
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大挙医学部小児科学教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=821
end-page=830
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on the Sulfur Metabolism in Infants Part I. Some Suggestion for the Quautative Analysis of Total Sulfur in Milk, Faces and Urine and the Total Sulfur Contents in Various Milk
kn-title=乳児の硫黄代謝に関する研究 第1編 乳汁，屎及び尿中の総硫黄定量法の考案並びに各種乳汁中の総硫黄量
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=There are numerous articles concerning the estination of total sulfur in organic substances and yet the results obtained hitherto are not by any means quite satisfactory. The gratest difficulty encountered in the estination of sulfur seems to lie in the insufficient ashing of the substance. Therefore, the author studied various ashing metheds and finally modified Bethge's wet ashing in the following manner: 1, Ammoniated vanadium (NH(4)VO(3)) is added as an oxidizing catalyst. 2. As an indicator of the complete oxidation potassium chromate (K(2)Cr(2)O(7)) is used. 3. The ratio of acid mixture is set in the proportion of three parts perohloric acid to two parts nitric acid. 4. The reduction mixture is placed into an ampule filled with pitrogan immediately after it is prepared and is sealed tightly, and the quantity of the mixture to be added is increased. By the modified method mentioned above it has been possible to raise the recovery rate of sulfur added as much as 95.4 per Gent, proving that this method is sufficiently useful for the estimation of the total sulfur in milk, urine and faces. In the estimations of total sulfur of various milk such as breast milk, milk on the market and 18% solution of regulated powered milk the average contents of total sulfur have been found to be 11.7 mg and 31.8 mg per dl respectively.
en-copyright=
kn-copyright=

en-aut-name=HamadaGibun
en-aut-sei=Hamada
en-aut-mei=Gibun
kn-aut-name=濱田義文
kn-aut-sei=濱田
kn-aut-mei=義文
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部小児科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=811
end-page=820
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Serum Hepatitis Resulted from Blood Transfusion
kn-title=輸血による血清肝炎について
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=In recent years there have been many cases, with increasing frequency, of serum hepatitis resulted from blood transfusion. The purpose of this study was to investigate the incidence, clinical feature, prognosis and prophylaxis of serum hepatitis followed by blood transfusion. The results obtained were as follows; 1) Incidence of serum hepatitis among the patients who had blood transfusion at local institutions in Okayama City was 3.3% in 1957 and 4.7% in 1958, on the other hand, at Okayama University Hospital in 1958 it was 5.0% in the First Surgical Division, 5.4% the Second Surgery and 5.2% OBGYN respectively. The patients with serum hepatitis had
received the amount 2,600 to 1,120 cc of blood, whereas 810 to 1,120 cc in the cases who never developed serum hepatitis after blood transfusion. 2) Mean incubation period was 72.8 days ranging 19 to 180 days calculated from the date of last blood transfusion. Prodremal stage varied from 1 to 20 days, average 6.1 days, icteric stage 7 to 15 days, average 35.8 days, and convalescent stage 7 to 200 days, average 30.0 days. 3) Characteristic initial symptoms were anorexia, malaise and jaundice by which fairly number of the cases noticed the onset of the disease. Few had febrile course but low grade in most of the cases. 4) Laboratory data were obtained from the 20 cases of serum hepatitis admitted to our First Mebical Division. Serum bilirubin showed the maximum level on the 10 th day, average 13.0 mg% . No significant changes were noted in peripheral blood picture but for a slight initial monocytosis. SGO-T and SGP-T presented a elevation earlier than that of serum bilirubin, maximum on or about the 5 th day and then decreased abruptly. Serum colloidal liver function tests; in initial stage, positive Takata's reaction in 51.%, positive CCF 46% and TTT 58% were noted, but even after 100 th day Takata's reaction was positive in 25% of the cases. 5) Follow-up studies were made on 49 serum hepatitis cases discharged from our hospital with complete recovery. 69% of these had subjective symptems in some sort or another. Enlargement of the liver was noted in 20% of the cases. 33 cases were studied with special reference to liver function tests and liver biopsy. It was revealed that 43% of the cases still had impairment of liver function and that by means of liver biopsy, postnecrotic cirrhosis was found 9.1% of the cases. Therefore, the prognosis of serum hepatitis of this type was considered to be grave. 6) For the purpose of prophylaxis, 300 to 600 mg of gamma globulin was simultaneously administered on blood transfusion in 38 cases. Inspite of this, 4 cases suffered from serum hepatitis later on, and no definite prophylactic effect of gamma globulin was noted.
en-copyright=
kn-copyright=

en-aut-name=KosakaKiyowo
en-aut-sei=Kosaka
en-aut-mei=Kiyowo
kn-aut-name=小坂淳夫
kn-aut-sei=小坂
kn-aut-mei=淳夫
aut-affil-num=1
ORCID=

en-aut-name=NagashimaHideo
en-aut-sei=Nagashima
en-aut-mei=Hideo
kn-aut-name=長島秀夫
kn-aut-sei=長島
kn-aut-mei=秀夫
aut-affil-num=2
ORCID=

en-aut-name=YamabukiTakahiro
en-aut-sei=Yamabuki
en-aut-mei=Takahiro
kn-aut-name=山吹隆寛
kn-aut-sei=山吹
kn-aut-mei=隆寛
aut-affil-num=3
ORCID=

en-aut-name=YamamotoShigeru
en-aut-sei=Yamamoto
en-aut-mei=Shigeru
kn-aut-name=山本繁
kn-aut-sei=山本
kn-aut-mei=繁
aut-affil-num=4
ORCID=

en-aut-name=UedaYutaka
en-aut-sei=Ueda
en-aut-mei=Yutaka
kn-aut-name=植田胖
kn-aut-sei=植田
kn-aut-mei=胖
aut-affil-num=5
ORCID=

en-aut-name=EndoKenichi
en-aut-sei=Endo
en-aut-mei=Kenichi
kn-aut-name=遠藤憲一
kn-aut-sei=遠藤
kn-aut-mei=憲一
aut-affil-num=6
ORCID=

en-aut-name=KusudoHiroshi
en-aut-sei=Kusudo
en-aut-mei=Hiroshi
kn-aut-name=楠戸宏
kn-aut-sei=楠戸
kn-aut-mei=宏
aut-affil-num=7
ORCID=

en-aut-name=OnoNobuhiro
en-aut-sei=Ono
en-aut-mei=Nobuhiro
kn-aut-name=小野延宏
kn-aut-sei=小野
kn-aut-mei=延宏
aut-affil-num=8
ORCID=

en-aut-name=KobashiNobuo
en-aut-sei=Kobashi
en-aut-mei=Nobuo
kn-aut-name=小橋暢夫
kn-aut-sei=小橋
kn-aut-mei=暢夫
aut-affil-num=9
ORCID=

en-aut-name=AsadaKiyotaka
en-aut-sei=Asada
en-aut-mei=Kiyotaka
kn-aut-name=浅田清隆
kn-aut-sei=浅田
kn-aut-mei=清隆
aut-affil-num=10
ORCID=

en-aut-name=KajiMasayoshi
en-aut-sei=Kaji
en-aut-mei=Masayoshi
kn-aut-name=加地正義
kn-aut-sei=加地
kn-aut-mei=正義
aut-affil-num=11
ORCID=

en-aut-name=KitagawaToshinori
en-aut-sei=Kitagawa
en-aut-mei=Toshinori
kn-aut-name=北川紀典
kn-aut-sei=北川
kn-aut-mei=紀典
aut-affil-num=12
ORCID=

en-aut-name=ShinoharaToshio
en-aut-sei=Shinohara
en-aut-mei=Toshio
kn-aut-name=篠原敏夫
kn-aut-sei=篠原
kn-aut-mei=敏夫
aut-affil-num=13
ORCID=

en-aut-name=TakakiTadateru
en-aut-sei=Takaki
en-aut-mei=Tadateru
kn-aut-name=高木直輝
kn-aut-sei=高木
kn-aut-mei=直輝
aut-affil-num=14
ORCID=

en-aut-name=NishidaTakeshi
en-aut-sei=Nishida
en-aut-mei=Takeshi
kn-aut-name=西田彪
kn-aut-sei=西田
kn-aut-mei=彪
aut-affil-num=15
ORCID=

en-aut-name=NagoshiKazuma
en-aut-sei=Nagoshi
en-aut-mei=Kazuma
kn-aut-name=名越一馬
kn-aut-sei=名越
kn-aut-mei=一馬
aut-affil-num=16
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=6
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=7
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=8
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=9
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=10
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=11
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=12
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=13
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=14
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=15
en-affil=
kn-affil=岡山大学医学部第一内科教室

affil-num=16
en-affil=
kn-affil=岡山大学医学部第一内科教室
END

start-ver=1.4
cd-journal=joma
no-vol=72
cd-vols=
no-issue=3
article-no=
start-page=801
end-page=810
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1960
dt-pub=19600228
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Epidemiological Observations on Infectious Hepatitis Prevailed in Okayama Prefecture
kn-title=岡山県における流行性肝炎の流行に関する検討
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=6246 infectious hepatitis cases treated at 25 hospitals located in Okayama Prefecture during the last six years, 1952 to 1957, were studied mainly from the epidemiological point of view, and the following results were obtained. 1) Infectious hepatitis has been prevailed all over the prefecture since the initial epidemic in 1951. As the mode of epidemic became protracted, chronic and abortive forms were prone to increase in number. The ratio of total patients to infectious hepatitis cases was 1.27 per cent. 2) Extensive infections among villagers were noted in 73 hamlets, and it was presumed that the epidemic has been prevailed over the whole prefecture taking a hamlet, village or a town as unit. Infections among family were noted in 62 families, however, fnrther detailed study in the epidemic areas might show the higher morbidity. It was not certain whether these infections were entirely family or simultaneous infections. 3) As to seasonal occurence, considerable number of cases had onset of the disease during the period of early summer to early fall. 4) As to age, it has ranged mostly from the second to third decade, rather many in children but not rare in the aged. As to sex, predominant in males in general, but considerable differences were seen among hospitals and times. No definite relationship was noted between the epidemc and sex. 5) Throughout the last six years there have been 38.7 per cent of chronic hepatitis cases. In 41.3 per cent of the whole patients presented jaundice in their clinical courses. The fact that the longer the period of the epidemic the more increase increase in anicteric cases was noted. 6) Two year's follow-up studies after the epidemic, showed 209 of relapsed cases in whom 36.4 per cent were icteric. 7) 110 cases has jaundice, which was thought to be infectious hepatitis, in the past. Some of them were presumably reinfections or superinfections but definite conclusion could not be made. 8) 20 cases of fulminant hepatitis, malignant type of infectious hepatitis, and 6 cases of protracted form were studied. 22 cases of them were fatal. Such severe hepatitis patients were seen mainly in males of the second and third decades. 9) 61 cases (0.98%) developed postnecrotic cirrhosis, and 10 cases of them were fatal. 10) Serum hepatitis was noted in 1.6 per cent of the whole patients seen in Medical Services at 18 hospitals in Okayama Prefecture during the last six years, 1952 to 1957. No definite correlation between the epidemic of infectious hepatitis and outbreak of serum hepatitis was noted.
en-copyright=
kn-copyright=

en-aut-name=KosakaKiyowo
en-aut-sei=Kosaka
en-aut-mei=Kiyowo
kn-aut-name=小坂淳夫
kn-aut-sei=小坂
kn-aut-mei=淳夫
aut-affil-num=1
ORCID=

en-aut-name=NagashimaHideo
en-aut-sei=Nagashima
en-aut-mei=Hideo
kn-aut-name=長島秀夫
kn-aut-sei=長島
kn-aut-mei=秀夫
aut-affil-num=2
ORCID=

en-aut-name=ShimadaYoshihiro
en-aut-sei=Shimada
en-aut-mei=Yoshihiro
kn-aut-name=島田宜浩
kn-aut-sei=島田
kn-aut-mei=宜浩
aut-affil-num=3
ORCID=

en-aut-name=YamabukiTakahiro
en-aut-sei=Yamabuki
en-aut-mei=Takahiro
kn-aut-name=山吹隆寛
kn-aut-sei=山吹
kn-aut-mei=隆寛
aut-affil-num=4
ORCID=

en-aut-name=KawaguchiMasamitsu
en-aut-sei=Kawaguchi
en-aut-mei=Masamitsu
kn-aut-name=川口正光
kn-aut-sei=川口
kn-aut-mei=正光
aut-affil-num=5
ORCID=

en-aut-name=YamamotoShigeru
en-aut-sei=Yamamoto
en-aut-mei=Shigeru
kn-aut-name=山本繁
kn-aut-sei=山本
kn-aut-mei=繁
aut-affil-num=6
ORCID=

en-aut-name=OhtaYasuyuki
en-aut-sei=Ohta
en-aut-mei=Yasuyuki
kn-aut-name=太田康幸
kn-aut-sei=太田
kn-aut-mei=康幸
aut-affil-num=7
ORCID=

en-aut-name=UjikeMutsuo
en-aut-sei=Ujike
en-aut-mei=Mutsuo
kn-aut-name=氏家睦夫
kn-aut-sei=氏家
kn-aut-mei=睦夫
aut-affil-num=8
ORCID=

en-aut-name=KusakaYoshiro
en-aut-sei=Kusaka
en-aut-mei=Yoshiro
kn-aut-name=草加芳郎
kn-aut-sei=草加
kn-aut-mei=芳郎
aut-affil-num=9
ORCID=

en-aut-name=MitsudaToshihiro
en-aut-sei=Mitsuda
en-aut-mei=Toshihiro
kn-aut-name=光田利弘
kn-aut-sei=光田
kn-aut-mei=利弘
aut-affil-num=10
ORCID=

en-aut-name=KiharaTsuyoshi
en-aut-sei=Kihara
en-aut-mei=Tsuyoshi
kn-aut-name=木原彊
kn-aut-sei=木原
kn-aut-mei=彊
aut-affil-num=11
ORCID=

en-aut-name=KondoTadasuke
en-aut-sei=Kondo
en-aut-mei=Tadasuke
kn-aut-name=近藤忠亮
kn-aut-sei=近藤
kn-aut-mei=忠亮
aut-affil-num=12
ORCID=

en-aut-name=HaraokaSyoichi
en-aut-sei=Haraoka
en-aut-mei=Syoichi
kn-aut-name=原岡昭一
kn-aut-sei=原岡
kn-aut-mei=昭一
aut-affil-num=13
ORCID=

en-aut-name=AmiokaTadashi
en-aut-sei=Amioka
en-aut-mei=Tadashi
kn-aut-name=網岡忠
kn-aut-sei=網岡
kn-aut-mei=忠
aut-affil-num=14
ORCID=

en-aut-name=IshimitsuTetsusaburo
en-aut-sei=Ishimitsu
en-aut-mei=Tetsusaburo
kn-aut-name=石光鉄三郎
kn-aut-sei=石光
kn-aut-mei=鉄三郎
aut-affil-num=15
ORCID=

en-aut-name=KonoHiroya
en-aut-sei=Kono
en-aut-mei=Hiroya
kn-aut-name=河野浩哉
kn-aut-sei=河野
kn-aut-mei=浩哉
aut-affil-num=16
ORCID=

en-aut-name=MitsumotoToshiro
en-aut-sei=Mitsumoto
en-aut-mei=Toshiro
kn-aut-name=光本敏郎
kn-aut-sei=光本
kn-aut-mei=敏郎
aut-affil-num=17
ORCID=

en-aut-name=AisakaTadakazu
en-aut-sei=Aisaka
en-aut-mei=Tadakazu
kn-aut-name=相坂忠一
kn-aut-sei=相坂
kn-aut-mei=忠一
aut-affil-num=18
ORCID=

en-aut-name=KosakaChuihiro
en-aut-sei=Kosaka
en-aut-mei=Chuihiro
kn-aut-name=小坂忠一郎
kn-aut-sei=小坂
kn-aut-mei=忠一郎
aut-affil-num=19
ORCID=

en-aut-name=MoritaniYui
en-aut-sei=Moritani
en-aut-mei=Yui
kn-aut-name=森谷有為
kn-aut-sei=森谷
kn-aut-mei=有為
aut-affil-num=20
ORCID=

en-aut-name=TabuchiHiroshi
en-aut-sei=Tabuchi
en-aut-mei=Hiroshi
kn-aut-name=田渊博司
kn-aut-sei=田渊
kn-aut-mei=博司
aut-affil-num=21
ORCID=

en-aut-name=HashimotoKyoji
en-aut-sei=Hashimoto
en-aut-mei=Kyoji
kn-aut-name=橋本恭治
kn-aut-sei=橋本
kn-aut-mei=恭治
aut-affil-num=22
ORCID=

en-aut-name=KimuraKenichi
en-aut-sei=Kimura
en-aut-mei=Kenichi
kn-aut-name=木村健一
kn-aut-sei=木村
kn-aut-mei=健一
aut-affil-num=23
ORCID=

en-aut-name=KonoHiroshi
en-aut-sei=Kono
en-aut-mei=Hiroshi
kn-aut-name=河野宏
kn-aut-sei=河野
kn-aut-mei=宏
aut-affil-num=24
ORCID=

en-aut-name=TamaoHiroyasu
en-aut-sei=Tamao
en-aut-mei=Hiroyasu
kn-aut-name=玉尾博康
kn-aut-sei=玉尾
kn-aut-mei=博康
aut-affil-num=25
ORCID=

en-aut-name=HiguchiYosimitsu
en-aut-sei=Higuchi
en-aut-mei=Yosimitsu
kn-aut-name=樋口祥光
kn-aut-sei=樋口
kn-aut-mei=祥光
aut-affil-num=26
ORCID=

en-aut-name=YahataKatsumi
en-aut-sei=Yahata
en-aut-mei=Katsumi
kn-aut-name=八幡勝美
kn-aut-sei=八幡
kn-aut-mei=勝美
aut-affil-num=27
ORCID=

en-aut-name=ImaiHarujiro
en-aut-sei=Imai
en-aut-mei=Harujiro
kn-aut-name=今井春路郎
kn-aut-sei=今井
kn-aut-mei=春路郎
aut-affil-num=28
ORCID=

en-aut-name=KameyamaIchiro
en-aut-sei=Kameyama
en-aut-mei=Ichiro
kn-aut-name=亀山一郎
kn-aut-sei=亀山
kn-aut-mei=一郎
aut-affil-num=29
ORCID=

en-aut-name=ArijiSumiro
en-aut-sei=Ariji
en-aut-mei=Sumiro
kn-aut-name=有地澄郎
kn-aut-sei=有地
kn-aut-mei=澄郎
aut-affil-num=30
ORCID=

en-aut-name=FujimoriYasuhiko
en-aut-sei=Fujimori
en-aut-mei=Yasuhiko
kn-aut-name=藤森恭彦
kn-aut-sei=藤森
kn-aut-mei=恭彦
aut-affil-num=31
ORCID=

en-aut-name=NakagawaSyoso
en-aut-sei=Nakagawa
en-aut-mei=Syoso
kn-aut-name=中川昌壮
kn-aut-sei=中川
kn-aut-mei=昌壮
aut-affil-num=32
ORCID=

en-aut-name=HiranoYutaka
en-aut-sei=Hirano
en-aut-mei=Yutaka
kn-aut-name=平野寛
kn-aut-sei=平野
kn-aut-mei=寛
aut-affil-num=33
ORCID=

en-aut-name=KobayashiToshinari
en-aut-sei=Kobayashi
en-aut-mei=Toshinari
kn-aut-name=小林敏成
kn-aut-sei=小林
kn-aut-mei=敏成
aut-affil-num=34
ORCID=

en-aut-name=SeidoIchiro
en-aut-sei=Seido
en-aut-mei=Ichiro
kn-aut-name=清藤一郎
kn-aut-sei=清藤
kn-aut-mei=一郎
aut-affil-num=35
ORCID=

en-aut-name=TanabeIsao
en-aut-sei=Tanabe
en-aut-mei=Isao
kn-aut-name=田辺功
kn-aut-sei=田辺
kn-aut-mei=功
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ORCID=

en-aut-name=TakedaKazuhisa
en-aut-sei=Takeda
en-aut-mei=Kazuhisa
kn-aut-name=武田和久
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kn-aut-mei=和久
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ORCID=

en-aut-name=HayashiShinichiro
en-aut-sei=Hayashi
en-aut-mei=Shinichiro
kn-aut-name=林愼一郎
kn-aut-sei=林
kn-aut-mei=愼一郎
aut-affil-num=38
ORCID=

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affil-num=24
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kn-affil=岡山大学医学部第一内科教室

affil-num=25
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kn-affil=岡山大学医学部第一内科教室

affil-num=26
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kn-affil=岡山大学医学部第一内科教室

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kn-affil=岡山大学医学部第一内科教室

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affil-num=38
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kn-affil=岡山大学医学部第一内科教室
END